盐酸利托君与硫酸镁联合治疗早产胎膜早破的临床疗效分析
Clinical efficacy of ritodrine hydrochloride combined with magnesium sulfate in the treatment of preterm premature rupture of membranes
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摘要: 目的：探讨盐酸利托君与硫酸镁联合治疗早产胎膜早破的临床疗效。方法：90例早产胎膜早破病人按照随机数字表法分为观察组及对照组，每组45例。对照组使用硫酸镁单药治疗，观察组在对照组基础上给予盐酸利托君治疗。评价2组治疗效果。结果：观察组治疗有效率为97.78%，高于对照组的86.67%（P<0.05）；治疗后2组焦虑情绪均显著改善（P<0.01），观察组改善幅度显著大于对照组（P<0.01）；观察组产妇宫缩抑制时间、孕龄延长时间、新生儿出生体质量及Apgar评分均显著优于对照组（P<0.01）；观察组新生儿并发症总发生率显著低于对照组（P<0.05），2组不良反应发生率差异无统计学意义（P>0.05）。结论：盐酸利托君联合硫酸镁可抑制早产胎膜早破患者子宫收缩、延长孕期，改善病人负性情绪及母婴结局，较单一硫酸镁治疗效果更好。Abstract: Objective:To investigate the clinical efficacy of ritodrine hydrochloride combined with magnesium sulfate in the treatment of preterm premature rupture of membranes.Methods:Ninety patients with preterm premature rupture of membranes were divided into the observation group and control group according to the random number table method(45 cases each group).The control group were treated with magnesium sulfate,and the observation group were additionally treated with ritodrine hydrochloride based on the control group.Results:The effective treatment rate in observation group(97.78%) was higher than that in control group(86.67%)(P<0.05).The anxiety in two groups were significantly improved after treatment(P<0.01),and the improvement in observation group was greater than that in control group(P<0.01).The time of contraction inhibition,pregnancy extension time,neonatal birth weight and Apgar score in observation group were significantly better than those in control group(P<0.01).The total incidence rate of neonatal complications in observation group was significantly lower than that in control group(P<0.05),but there was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).Conclusions:Ritodrine hydrochloride combined with magnesium sulfate can inhibit the uterine contraction,prolong pregnancy,and improve the negative emotion and maternal and neonatal outcome in patients with preterm premature rupture of membranes,and the treatment effect of which is better than that of single magnesium sulfate.
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