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肝豆状核变性(hepatolenticular degeneration,HLD),是由于位于13号染色体长臂1区4带3亚带的ATP7B基因突变,所致的常染色体隐性遗传病。HLD是罕见病,其全球范围内的患病率约为2/10万[1],中国人群的患病率约为5.87/10万[2]。HLD的发病机制是由于机体内多余的铜不能排出体外,沉积于肝脏、脑基底核、眼角膜、肾脏等脏器,所致相应器官产生一系列的病理改变,机体内多余的铜最易沉积于肝脏,肝脏病理过程的最终结局多为肝硬化,部分病人会出现暴发性肝衰竭。在临床工作中发现,HLD病人较其他肝脏病变病人更易并发脾脏肿大,HLD病人肝脏的病理变化与脾脏的增大互为因果。本研究回顾性分析因HLD就诊于我院的病人,研究病人脾脏增大对其肝脏的硬度是否产生影响,为临床在治疗HLD合并脾脏肿大的病人提供更多的影像学资料。
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本次研究共计纳入38例HLD病人,其中脾脏不大的病人14例,并发脾脏增大的病人共计24例,2组间肝右叶SWV平均值差异有统计学意义(P<0.05)(见表 1)。
分组 n SWV平均值/(m/s) 脾脏不大 14 1.69±0.21 脾脏增大 24 1.94±0.34 t — 2.48 P — <0.05 表 1 HLD病人肝右叶SWV值(x±s)
实时剪切波弹性成像技术监测肝豆状核变性病人合并脾脏肿大对肝脏硬度的影响
Effect of the hepatolenticular degeneratioin complicated with splenomegaly on the liver hardness monitored by real-time shear wave elastography
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摘要:
目的利用实时剪切波弹性成像技术测量肝豆状核变性病人肝脏剪切波速度(shear wave velocity, SWV),定量评估合并脾脏肿大的肝豆状核变性病人肝脏质地的变化情况。 方法根据肝豆状核变性病人脾脏是否增大,将病人分为2组,应用配备声脉冲辐射力成像软件的西门子ACUSON-OXANA3型彩色多普勒超声诊断仪,测量研究对象肝右叶SWV,并利用SPSS25.0软件对2组病人的肝右叶SWV值进行独立样本t检验。 结果脾脏不大的病人14例,并发脾脏增大的病人共计24例,2组间肝右叶SWV值差异有统计学意义(P < 0.05)。 结论分组定量测量肝脏SWV速度,有助于临床在肝豆状核变性病人治疗过程中及时调整治疗方案。 Abstract:ObjectiveTo evaluate the effects of hepatolenticular degeneration(HLD)complicated with splenomegaly on liver hardness through real-time shear wave elastography measuring the liver shear wave velocity(SWV). MethodsThe patients with HLD were divided into two groups according to the splenomegaly.The right liver lobe SWV of patients were measured using Siemens ACUSON-OXANA3 color doppler ultrasonic diagnostic instrument with acoustic radiation force impulse imaging(ARFI), and the right liver lobe SWV values in two groups were analyzed by independent sample t test using SPSS 25.0 software. ResultsFourteen patients without splenomegaly and 24 patients with splenomegaly were identified in two groups, respectively.The difference of the SWV value of the right lobe of liver between two groups was statistically significant(P < 0.05). ConclusionsThe quantitative measurement of liver SWV velocity is helpful to timely adjust the treatment plan in the clinical treatment of patients with hepatolenticular degeneration. -
Key words:
- hepatolenticular degeneration /
- splenomegaly /
- ultrasound /
- shear wave elastography
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表 1 HLD病人肝右叶SWV值(x±s)
分组 n SWV平均值/(m/s) 脾脏不大 14 1.69±0.21 脾脏增大 24 1.94±0.34 t — 2.48 P — <0.05 -
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