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程序性坏死(necroptosis)是继细胞凋亡、坏死和自噬后被新发现的一种新的细胞死亡方式,主要表现为典型的坏死样形态。但与坏死相比,其过程受到一系列蛋白的精确调控。经典的necroptosis需要由起始因子介导,随即形成RIP1-RIP3-MLKL死亡复合体,同时发现存在由RIP3-CaMKⅡ通路介导的新通路。Necroptosis与多种心脑血管疾病及肿瘤的发生有关,若能对其调控方式进行抑制或阻断可缓解相关疾病的发生,将为药品开发及临床治疗提供新思路。
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