[2] Hartmann TN,Burger JA,Glodek A,et al.CXCR4 chemokinereceptor and integrin signaling co-operate in mediating adhesionand chemoresistance in small cell lung cancer(SCLC) cells[J].Oncogene,2005,24(27) : 4462 - 4471.
[2] Kang H,Mansel RE, Jiang WG.Genetic manipulation of stromalcell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells[J].Int J Oncol,2005,26(5) : 1429 - 1434.
[3] Nagasawa T,Kikutani H,Kishimoto T.Molecular cloning andstructure of a pre-B-cell growth-stimulating factor[J].Proc NatlAcad Sci USA,1994,91(6) : 2305 - 2309.
[4] Zou YR,Kottmann AH,Kuroda M,et al.Function of thechemokine receptor CXCR4 in haematopoiesis and in cerebellardevelopment[J].Nature,1998,393(6685) : 595 - 599.
[5] Hernndez-Lpez C,Varas A,Sacedn R,et al.The CXCL12/CXCR4 pair in aged human thymus[J].Neuroimmunomodulation,2010, 17(3) : 217 - 220.
[6] Babcock GJ,Farzan M,Sodroski J,et al.Ligand-independentdimerization of CXCR4,a principal HIV-1 coreceptor[J].J BiolChem,2003,278(5) : 3378 - 3385.
[7] Sun YX,Schneider A,Jung Y,et al.Skeletal localization andneutralization of the CXCL12 (CXCL12 )/CXCR4 axis blocksprostate cancer metastasis and growth in osseous sites in vivo[J].J Bone Miner Res,2005,20(2) : 318 - 329.
[8] Katayama A,Ogino T,Bandoh N, et al.Expression of CXCR4 andits down-regulation by IFN- in head and neck squamous cellcarcinoma[J].Clin Cancer Res,2005,11(8) : 2937 - 2946.
[9] Dziembowska M,Tham TN,Lau P,et al.A role for CXCR4signaling in survival and migration of neural and oligodendrocyteprecursors[J].Glia,2005,50(3) : 258 - 269.
[10] Mellado M,Rodrguez-Frade JM,Maes S,et al.Chemokinesignaling and functional responses: the role of receptordimerization and TK pathway activation[J].Annu Rev Immunol,2001,19: 397 - 421.
[11] Rubin JB.Chemokine signaling in cancer: one hump or two[J].Semin Cancer Biol,2009,19(2) : 116 - 122.
[12] Ward SG.T lymphocytes on the move: chemokines,PI 3-kinaseand beyond[J].Trends Immunol,2006,27(2) : 80 - 87.
[13] Zhang XF,Wang JF,Matczak E, et al.Janus kinase 2 is involvedin stromal cell-derived factor-1-induced tyrosine phosphorylationof focal adhesion proteins and migration of hematopoieticprogenitor cells[J].Blood,2001,97(11) : 3342 - 3348.
[14] Bendall LJ,Baraz R,Juarez J,et al.Defective p38 mitogenactivatedprotein kinase signaling impairs chemotaxic but notproliferative responses to stromal-derived factor-1 in acutelymphoblastic leukemia[J].Cancer Res,2005,65 (8) : 3290 -3298.
[15] Barbero S,Bonavia R,Bajetto A, et al.Stromal cell-derived factor1 stimulates human glioblastoma cell growth through theactivation of both extracellular signal-regulated kinases 1/2 andAkt[J].Cancer Res,2003,63(8) : 1969 - 1974.
[16] Vlahakis SR,Villasis-Keever A,Gomez T, et al.G protein-coupledchemokine receptors induce both survival and apoptotic signalingpathways[J].J Immunol,2002,169(10) : 5546 - 5554.
[17] Suzuki Y,Rahman M,Mitsuya H.Diverse transcriptional responseof CD4 + T cells to stromal cell-derived factor (SDF ) -1: cellsurvival promotion and priming effects of SDF-1 on CD4 + T cells[J].J Immunol,2001,167(6) : 3064 - 3073.
[18] Ngo HT,Leleu X,Lee J,et al.SDF-1/CXCR4 and VLA-4interaction regulates homing in Waldenstrom macroglobulinemia[J].Blood,2008,112(1) : 150 - 158.
[19] Balabanian K,Levoye A,Klemm L, et al.Leukocyte analysis fromWHIM syndrome patients reveals a pivotal role for GRK3 inCXCR4 signaling[J].J Clin Invest,2008,118(3) : 1074 - 1084.
[20] Fischer L,Korfel A,Pfeiffer S,et al.CXCL13 and CXCL12 incentral nervous system lymphoma patients[J].Clin Cancer Res,2009,15(19) : 5968 - 5973.
[21] Sauv K,Lepage J,Sanchez M, et al.Positive feedback activationof estrogen receptors by the CXCL12-CXCR4 pathway[J].CancerRes,2009,69(14) : 5793 - 5800.
[22] Singh S,Bond VC,Powell M,et al.CXCR4-gp 120-IIIBinteractions induce caspase-mediated apoptosis of prostate cancercells and inhibit tumor growth[J].Mol Cancer Ther,2009,8(1) : 178 - 184.
[23] Gassmann P,Haier J,Schluter K, et al.CXCR4 regulates the earlyextravasation of metastatic tumor cells in vivo[J].Neoplasia,2009,11(7) : 651 - 661.
[24] Kwong J,Kulbe H,Wong D, et al.An antagonist of the chemokinereceptor CXCR4 induces mitotic catastrophe in ovarian cancercells[J].Mol Cancer Ther,2009,8(7) : 1893 - 1905.
[25] Muller A,Homey B,Soto H,et al.Involvement of chemokinereceptors in breast cancer metastasis[J].Nature,2001,410(6824) : 50 - 56.
[26] Salvucci O,Bouchard A,Baccarelli A, et al.The role of CXCR4receptor expression in breast cancer: a large tissue microarraystudy[J].Breast Cancer Res Treat,2006,97(3) : 275 - 283.
[27] Kang H,Mansel RE, Jiang WG.Genetic manipulation of stromalcell derived factor-1 attests the piotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells[J].Int Oncol,2005,26(5) : 1429 - 1434.
[28] Sutton A,Friand V,Brule-Donneger S, et al.Stromal cell-derivedfactor-l/chemokine(C-X-C motif ) ligand 12 stimulates humanhepatoma cell growth,migration,and invasion[J].Mol CancerRes,2007,5(1) : 21 - 33.
[29] Kang H,Watkins G,Douglas-Jones A, et al.The elevated level ofCXCR4 is correlated with nodal metastasis of human breast cancer[J].Breast,2005,14(5) : 360 - 367.
[30] Castellone MD,Guarino V,De Falco V,et al.Functionalexpression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroidcarcinomas[J].Oncogene,2004,23(35) : 5958 - 5967.
[31] Schimanski CC,Bahre R,Gockel I,et al.Dissemination ofhepatocellular caranoma is mediated via chemokine receptorCXCR4[J].Br J Cancer,2006,95(2) : 210 - 217.
[32] Tamamura H,Tsutsumi H,Fujii N.The chemokine receptorCXCR4 as a therapeutic target for several diseases[J].Mini RevMed Chem,2006,6(9) : 989 - 995.
[33] Yang QL,Ding YX,Chen CJ, et al.Suppression of murine breastcancer metastasis by selective inhibition of CXCR4 by syntheticpolypeptide derived from viral macrophage inflammatory proteinⅡ[J].Huazhong Univ Sci Technol,2011,31(4) : 497 - 503.
[34] Redjal N,Chan JA,Segal RA, et al.CXCR4 inhibition synergizeswith cytotoxic chemotherapy in gliomas[J].Clin Cancer Res,2006,12(22) : 6765 - 6771.