Clinical research of intravenous pretreatment with magnesium sulfate for inhibiting propofol-induced pain
-
1.
1. Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou Jiangsu 221002;
-
2.
2. Department of Anesthesiology, Chuzhou Second People′s Hospital, Chuzhou Anhui 239000;
-
3.
3. Department of Anesthesiology, Ningbo Women and Children′s Hospital, Ningbo Zhejiang 315012, China
-
Corresponding author:
LIU Gong-jian, Liugongjian61@ hotmail.com
-
Received Date:
2011-04-21
-
Abstract
Objective:To assess the efficacy of intravenous pretreatment with magnesium sulfate on propofol injection-induced pain.Methods:One hundred and sixty ASA Ⅰ -Ⅱ patients undergoing general anaesthesia were rando mly allocated into four groups:M,L,K and S group(forty in each group).A 20-gauge catheter was inserted into vein on the back of right hand for drug injection and anaesthesia,and with a rubber venous tourniquet 5 cm near wrist.In M,L,K and S group,patients were pretreated with i.v 20 mg /kg of magnesium sulfate(M),0.5 mg /kg of lidocaine (L),0.3 mg /kg of ketamine (K),and 5 ml normal saline (S),respectively.The occlusion was released after 1 min,2 mg /kg of propofol was injected into vein by the infusion at 0.5 ml /s.The incidence and intensity of pain was assessed by verbal rating scales (VRS).patients' MApand HR were recorded at the point of before administration,tourniquet released,after induction of anesthesia and endotracheal intubation.Results:The incidence of pain in M groupwas 25% compared to 55% for L group,50% for K groupand 95% for S group.The incidence and intensity of pain in all groups were significantly lower than in S group(P<0.01).The incidence of pain in M groupwas significantly lower than in L group(P<0.05),and was similar to K group; K groupwas similar to L group(P>0.05).The intensity of pain in M groupwas significantly lower than in L,K and N group(P<0.01),respectively,and there were no statistical differences in M,L and K group(P>0.05).There were no significant differences in MApand HR between all groups.Conclusions:Combined with tourniquet technique,intravenous pretreatment with magnesium sulfate,lidocaine and ketamine are effective in attenuating propofol-induced pain.However,it has been observed that pretreatment with magnesium sulfate was the most effective.
-
-
References
[2] Canbay O,Celebi N,Arun O,et al.Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain[J].Br J Anaesth,2008,100(1):95-98. |
[2]
|
Zahedi H,Nikooseresht M,Seifrabie M.Prevention of propofol injection pain with small-dose ketamine [J].Middle East J Anesthesiol,2009,20(3):401-404. |
[3] Oguzhan N,Gunday I,Turan A.Effect of magnesium sulfate infusion on sevoflurane consumption,hemodynamics,and perioperative opioid consumption in lumbar disc surgery[J].J Opioid Manag,2008,4(2):105-110. |
[4] Kaya S,Kararmaz A,Gedik R,et al.Magnesium sulfate reduces postoperative morphine requirement after remifentanil-based anesthesia[J].Med Sci Monit,2009,15(2):15-19. |
[5] Tauzin-Fin P,Sesay M,Svartz L,et al.Wound infiltration withmagnesium sulphate and ropivacaine mixture reduces postoperative tramadol requirements after radical prostatectomy [J].Acta Anaesthesiol Scand,2009,53(4):464-469. |
[6] Chen Y,Zhang Y,Zhu YL,et al.Efficacy and safety of an intraoperative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty[J].J Int Med Res,2009,37(6):1733-1741. |
[7] Crosby V,Wilcock A,Corcoran R.The safety and efficacy of a single dose(500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer[J].J Pain Symptom Manage,2000,19(1): 35-39. |
[8] Picard P,Tramr MR.Prevention of pain on injection with propofol:a quantitative systematic review[J].Anesth Analg,2000,9 0(4):963-969. |
[9] Lee SK.Pain on injection with propofol[J].Korean J Anesthesiol,2010,59(5):297-298. |
[10] Jalota L,Kalira V,George E,et al.Prevention of pain on injection of propofol:systematic review and meta-analysis[J].BMJ,2011,15:342. |
[11] 曹云飞,李建玉,吴新文,等.利多卡因预注与混用对丙泊酚注射痛的防治作用比较[J].广东医学,2007,28(10):1640-1642. |
[12] Hwang J,Park H P,Lim Y J,et al.Preventing pain on injection of propofol:a comparison between peripheral ketamine pre-treatment and ketamine added to propofol[J].Anaesth Intensive Care,2009,37(4):584-587. |
[13] Soave PM,Conti G,Costa R,et al.Magnesium and anaesthesia[J].Current Drug Targets,2009,10(8):734-743. |
-
-
Proportional views
-