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Monthly Established in March 1976

Supervisor: The Education Department of Anhui Province

Sponsor: Bengbu Medical College

ISSN1000-2200

CN34-1067/R

Editor: Editorial Board of Journal of Bengbu Medical College

Chief Editor:GAO Huai-quan

Editorial Director:YAO Ren-bin

Publication: Editorial Department of Journal of Bengbu Medical College

Postal code: 26-37

Price: Domestic ¥15.00,Overseas $10.00

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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Study on the effects and mechanism of MAPK pathway mediated by docosahexaenoic acid against atrial fibrillation
XU Qing-mei, MO Chen, ZHU Fei-yu, ZHANG Heng, WANG Hong-ju, GAO Qin, KANG Pin-fang, TANG Bi
2021, 46(1): 1-5.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.001
[Abstract](0) [PDF 1293KB](0)
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Objective: To investigate the possible mechanism of docosahexaenoic acid(DHA) regulating collagen expression by affecting the P38 MAPK pathway to play an anti-atrial fibrillation.Methods: Eighty SD rats sensitive to acetylcholine(66 μg/mL)-calcium chloride(50 mg/mL) mixture were randomly divided into the control group(CON group),control DHA treatment group(DHA group),atrial fibrillation group(AF group) and atrial fibrillation DHA treatment group(DHA+AF group)(20 rats in each group model of atrial fibrillation).The BL-420F tractive electrocardiogram and continuous double stimulation method were used to detect the atrial effective refractory period(ERP),the whole cell patch clamp technique was used to record the atrial muscle cell action potential duration(APD) change,the enzyme immunosorbent assay(ELISA) was used to detect the typeⅠ,Ⅲ collagen expression in atrial muscle tissue of rats,and the expression levels of P38 and P-PP38 and MKP 1 protein were detected using Western blotting.Results: The duration of atrial fibrillation in rats prolonged with the increasing of experimental time,while DHA could shorten the duration of atrial fibrillation(P<0.05 to P<0.01).The ERP and APD significantly shortened,while DHA could significantly prolong the atrial ERP and APD in AF group(P<0.01).There was no significant change in P38 protein among each group.Compared with the CON group,the expression level of P-P38 significantly increased,while the expression level of MKP-1 decreased in AF group(P<0.01). Compared with the AF group,the expression level of P-P38 significantly decreased,while the expression level of MKP-1 increased in the DHA+AF group(P<0.01).The results of ELISA showed that DHA could obviously down-regulate the typeⅠand Ⅲ collagen expression(P<0.01).Conclusions: DHA may play an anti-atrial fibrillation role by regulating P38 MAPK signal transduction pathway mediating collagen expression.
Effect of nerve growth factor on the proliferation and differentiation of rabbit dental pulp stem cells in vitro
LU Xiao-miao, JIANG Sheng, LI Xiao-liang, TIAN Rui-xue, LIU Shan-shan, ZHAO Li-li, ZHANG Kai
2021, 46(1): 6-9.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.002
[Abstract](0) [PDF 1726KB](0)
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Objective: To investigate the effects of nerve growth factor(NGF) on the proliferation and differentiation of rabbit dental pulp stem cells(DPSCs) in vitro,and provide a new clue for the repair of dental pulp tissue.Methods: The DPSCs from healthy New Zealand rabbits were isolated and cultured by tissue enzymedigestion method,and the morphology and growth changes of cells were observed under light microscope.The third passage DPSCs were divided into the blank group(only DPSCs),experimental group(DPSCs mixed with 100 g/L NGF) and control group(DPSCs mixed with mineralization solution).The cell morphology and alkaline phosphatase(ALP) activity in three groups were investigated after 7 days and 14 days of culture,and the mRNA expression levels of COL-1,Runx-2 and OCN were detected using RT-qPCR.Results: The DPSCs cultured in vitro grew well,adhered to the wall,and most of them were polygonal or spindle shaped with nest or colony growth.The ALP activity value in three groups after 14 d of culture were higher than that on the 7th day of culture,and the differences of which among three groups after 7 and 14 d of culture were significant(P<0.05).The results of RT-qPCR showed that the expression levels of COL-1,Runx-2 and OCN mRNA in experimental group after 14 d of culture were higher than those in blank group(P<0.05).Conclusions: The NGF can promote the proliferation and osteogenic differentiation of rabbit DPSCs,and the combined application effect of the two is better than that of DPSCs alone.
Study on the therapeutic dose of 5-fluorouracil in a new generation PDX model of colon cancer
LIU Jing, CHEN Zhan, LI Peng, LI Di, TU Yong-jiu
2021, 46(1): 10-13,17.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.003
[Abstract](0) [PDF 1572KB](0)
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Objective: To establish the patient-derived tumor xenografts(PDX)model of colorectal cancer(CRC),and explore the relationship among the anticancer effects,toxicity and dose of 5-fluorouracil(5-Fu).Methods: The fresh human CRC tissues were subcutaneously transplanted into immunodeficient mice to establish a PDX model,and the traceability of the test model was detected.The mice were treated with 5,10,20,40 and 60 mg/kg of 5-Fu,respectively,and the tumor volume,body mass and mortality were measured.Results: The PDX model was successfully established,and the traceability was 99.96%.The tumor inhibition rates of 5,10,20,40 and 60 mg/kg of 5-Fu were 33%,49%,68%,92% and 100%,respectively.Among them,the body weight of mice significantly lost in 40 mg/kg dose group,and the mortality of 60 mg/kg dose group was 100%.Conclusions: The efficacy and toxicity of 5-Fu are closely related to the doses,and the 10-20 mg/kg of 5-Fu is suitable for the efficacy evaluation of PDX model.
Effect of the propofol on the NLRP3 signaling pathway in mice with acute lung injury
FU Wei, CHENG Xiang-yang, LIU Di, LIU Gang
2021, 46(1): 14-17.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.004
[Abstract](0) [PDF 1542KB](0)
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Objective: To analyze the protective effects of propofol on the acute lung injury induced by lipopolysaccharide(LPS)and expression levels of thioredoxin-interacting protein(TXNIP)and nucleotide-binding domain-like receptor protein 3(NLRP3),and explore the possible mechanisms of lung protection with propofol.Methods: Forty ICR mice were divided into the control group(treatment with intraperitoneal injection of pH 7.4 phosphate buffer),LPS group(treatment with intraperitoneal injection of 30 mg/kg LPS),propofol group(treatment with intravenous injection of 40 mg/kg propofol)and propofol +LPS group(treatment with intraperitoneal injection of 30 mg/kg LPS after 20 min of intravenous injection of 40 mg/kg propofol)(10 mice in each group).The pathological analysis of lung tissue was conducted under light microscope,and the MDA content,SOD activity and expression levels of TXNIP and NLRP3 in pulmonary epithelial cells were detected.Results: The lung histopathological results showed that propofol could significantly reduced the acute lung injury induced by LPS in mice.Compared with the control group,the MDA content and SOD activity in the lung tissues of LPS group were significantly increased and decreased,respectively(P<0.01),and the expression levels of TXNIP,NLRP3 mRNA and protein were significantly up-regulated in LPS group(P<0.01).Compared with the LPS group,the MDA content and SOD activity were significantly decreased and increased in the propofol+LPS group,respectviely(P<0.01),and the expression levels of TXNIP and NLRP3 mRNA and protein in lung tissues of propofol+LPS group were significantly down-regulated(P<0.01).Conclusions: The intravenous preinjection of propofol can down-regulate the mRNA and protein expressions of TXNIP and NLRP3 in lung tissues,effectively alleviate the acute lung injury induced by LPS,and play a protective role in lung tissue.
Diagnostic value of dual-energy spectral CT material quantitative analysis in pancreatic fat deposition
LI Meng-ru, WEI Wei, ZHANG Long-long, ZHAO Ying-ming, ZHAO Jing
2021, 46(1): 18-21.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.005
[Abstract](0) [PDF 2492KB](0)
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Objective: To explore the diagnostic value of dual-energy spectral CT material quantitative analysis for pancreatic fat deposition.Methods: A total of 35 patients with metabolic syndrome,such as obesity,hyperglycemia and fatty liver,were selected as the observation group.The CT values of the head,body and tail of pancreas were measured on the single energy image of optimal keV value.The fat contents of the head,body and tail of pancreas were determined on the fat-water material image.The spectral curves of pancreatic tissues were obtained to make the average spectral curves.The results were compared with the fat contents measured in 30 patients who underwent abdominal CT scan for physical examination or other diseases in the control group.Results: Among 35 cases in the observation group,8 cases were found with normal body mass index,and the rest were overweight or obesity.The average CT value of pancreas decreased with the increase of body mass index (P<0.01),while the average fat content increased with the increase of body mass index(P<0.01).The energy CT value and water content of pancreatic tissues in observation group were significantly lower than those in control group,and the fat content was significantly higher than that in control group(P<0.01).Conclusions: Dual-energy spectral CT quantitative analysis can objectively and quantitatively describe the fat deposition in pancreas,and provide more valuable informations for early diagnosis and treatment in clinic.
Value of texture analysis based on spectral CT in predicting preoperative lymph node metastasis of gastric cancer
WANG Xiao-lei, GAO Yu-qing, XU He, ZHANG Shu-hai, LI Shu-hua, ZHAO Can-can, DUAN Shao-feng, XIE Zong-yu
2021, 46(1): 21-24.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.006
[Abstract](0) [PDF 1393KB](0)
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Objective: To study the value of spectral CT texture analysis in predicting preoperative lymph node metastasis in patients with gastric cancer.Methods: Eighty patients(including 57 cases in training group and 23 cases in verification group) with gastric cancer confirmed by surgical resection and pathology were retrospectively analyzed.The special texture analysis software AK was used to segment the lesions and extract the imaging features on the preoperative spectral CT 70 keV venous phase cross-sectional images.The Mann-Whitney U test was used to analyze the features between two groups,and the P<0.05 features were preserved.The discriminative features were further found by single factor logistic regression analysis.The minimum redundancy maximum correlation method(MRMR) was used to eliminate the 10 features with the highest correlation with the label.Stepwise multiple logistic regression was used to construct the prediction model and final model.The performance of the model was evaluated using ROC analysis.Results: In terms of texture features,the 10 radiology-related features selected by MRMR had better discriminative ability for training group and verification group(AUC>0.64),and the AUC of multivariate logistic regression prediction model was 0.79(0.69-0.89).Conclusions: The texture analysis based on spectral CT is expected to be a non-invasive tool for predicting preoperative lymph node metastasis in patients with gastric cancer.
Application value of the spectral CT imaging in the qualitative evaluation of metastatic lymph nodes of differently differentiated esophageal cancer
WEI Jun, MA Yi-chuan
2021, 46(1): 25-28,32.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.007
[Abstract](0) [PDF 1941KB](0)
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Objective: To explore the application value of spectral CT imaging in the qualitative evaluation of metastatic lymph nodes of differently differentiated esophageal cancer.Methods: The clinical data of 48 patients with esophageal squamous cell carcinoma confirmed by endoscopic pathology were retrospectively analyzed.All cases were detected using spectral CT chest plain scan and dual-phase enhanced scan before surgery.The short diameter of mediastinal lymph nodes,CT value at 70 keV arterial and iodine concentration in arterial and venous phases were measured,the normalized iodine concentration was calculated,and which was compared with the postoperative pathological results.Results: Among the 48 patients with esophageal squamous cell carcinoma,32 cases with lymph node metastasis and 16 cases without lymph node metastasis were confirmed by operation and pathology.The postoperative pathological results showed that 79 metastatic lymph nodes were found(including 14 highly differentiated squamous cell carcinoma metastatic lymph nodes,27 moderately differentiated squamous cell carcinoma metastatic lymph nodes and 38 poorly differentiated squamous cell carcinoma metastatic lymph nodes),and there were 32 non-metastatic lymph nodes.There was no statistical significance in the diagnosis of lymph node metastasis between spectral CT imaging and pathological results after surgery(P>0.05).The short diameter,CT70 keV and arterial phase hormalized iodine concentration in highly and moderately differentiated esophageal squamous cell carcinoma metastatic lymph nodes were higher than those in non-metastatic lymph nodes(P<0.05 to P<0.01).The short diameter,CT70 keV and arterial phase hormalized iodine concentration in pooryly differentiated esophageal squamous cell carcinoma metastatic lymph nodes were higher than those in non-metastatic lymph nodes(P<0.05 to P<0.01).The ROC curve analysis showed that the sensitivity and specificity of the combined of CT70 keV,normalized iodine concentration and spectral curve slope in arterial phase in the diagnosis of metastatic lymph node of esophageal cancer were 86.1% and 87.5%,respectively.Conclusions: The spectral CT imaging has important value in qualitative valuating the lymph nodes of differently differentiated esophageal cancer.It is helpful for N staging,clinical diagnosis and choice of treatment option of esophageal cancer.
Aapplication value of spectral CT in the evaluation of the differentiation degree of colorectal cancer
WANG Shu-qin, ZHU Guang-hui
2021, 46(1): 29-32.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.008
[Abstract](0) [PDF 1504KB](0)
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Objective: To investigate the application value of each parameter of 256-row Revolution spectral CT in evaluating the differentiation degree of colorectal cancer.Methods: Fifty patients with colorectal cancer diagnosed by colonoscopy or pathology were selected,and detected using the GSI spectral CT plain scan and dual-phase scan before surgery.The relevant spectral images were obtained through GSI Viewer software,the appropriate region of interest was delineated in the lesion,and the iodine base value(IC),water concentration,effective atomic number(Eff-Z),normalized iodine concentration(NIC) and energy spectral slope(K) of the lesion were measured.According to the pathological results,50 patients were divided into the low differentiation group and middle-high differentiation group.The spectral parameters were compared between two groups,and the diagnostic ability of each spectral parameter were analyzed using the receiver operating characteristic curve.Results: Among 50 patients,32 cases in middle-high differentiation group and 18 cases in low differentiation group were identified.The lymph node metastasis in low differentiation group was higher than that in middle-high differentiation group(P<0.05).There was no statistical significance in the IC,NIC,water concentration,Eff-Z and K of arterial phase,and water concentration and Eff-Z of venous phase between two groups(P>0.05).The IC,NIC and K of venous phase in low differentiation group were higher than those in middle-high differentiation group(P<0.05).The area under the curve,diagnostic threshold,sensitivity and specificity of venous phase IC,NIC,and K were (0.77,0.81 and 0.79),(18.31,0.56 and 2.07),(88.3%,83.3% and 88.9%) and (62.5%,75.0% and 68.7%),respectively.Conclusions: The parameters IC,NIC and K of spectral CT have high values in evaluating the differentiation of colorectal cancer.
Effect of smoking on the clinical indicators and renal pathology of IgA nephropathy
HUANG Dan-dan, XU Xing-xin, JIANG Xiao
2021, 46(1): 33-36.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.009
[Abstract](0) [PDF 1034KB](0)
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Objective: To investigate the effects of smoking on the clinical indicators and renal pathology of IgA nephropathy.Methods: The smoking status of 149 patients with IgA nephropathy was retrospectively analyzed,and its relationship with clinical indicators and renal pathological injury were analyzed.Results: Among 149 IgA nephropathy patients,30 cases were smokers(smoking group)and 119 cases were non-smokers(non-smoking group).The glomerular filtration rate in smoking group was significantly lower than that in non-smoking group(P<0.01),and the age,male ratio,and levels of triglyceride,blood glucose and urine β2 microglobulin,α1 microglobulin and 24 h urinary protein in smoking group were higher than those in non-smoking group(P<0.05 to P<0.01).The scores of renal interstitial fibrosis and glomerular capillary wall thickening in smoking group were higher than those in non-smoking group(P<0.05).The results of Pearson correlation analysis showed that the smoking amount was negatively correlated with eGFR(r=-0.219,P<0.05),and positively correlated with the scores of renal interstitial fibrosis and renal tubular atrophy(r=0.183,0.187,P<0.05).Conclusions: There is a correlation between smoking and renal function injury in IgA nephropathy patients.The chronic tubular interstitial lesion is the main feature of renal pathology caused by smoking.
Impact of carvedilol on the metabolism,inflammatory response and cardiac function of patients with diabetic cardiomyopathy
XIAO Ri-jun, HU Lan, GU Tie-bo, ZHOU Xiao-feng
2021, 46(1): 36-38,43.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.010
[Abstract](0) [PDF 1038KB](0)
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Objective: To discuss the impacts of carvedilol on metabolism,inflammatory response and cardiac function of patients with diabetic cardiomyopathy(DCM).Methods: One hundred and eighty DCM patients were divided into the control group(n=88)and observation group(n=92)according to random number method in our hospital.The control group were treated with conventional method,and the observation group were additionally treated with carvedilol(3.125~6.25 mg/d)based on conventional method.After 12 weeks of treatment,the biochemical indexes[including total cholesterol(TC),triglyceride(TG)and fasting blood-glucose(FBG)],inflammation markers[including high-sensitivity C-reactive protein(hs-CRP)and tumour necrosis factor-α(TNF-α)],heart function parameters[including left ventricular end diastolic diamete(LVEDd),left ventricular end-systolic diameter(LVEDs),left ventricular ejection fraction(LVEF),N-terminal pro-brain natriuretic peptid(NT-pro-BNP)and 6mmin walking distance] and adverse reaction were compared between two groups.Results: After treatment,the levels of hs-CRP and TNF-αin two groups significantly decreased(P<0.01),and the levels of hs-CRP and TNF-α in observation group were significantly lower than those in control group(P<0.01).After treatment,the levels of LVEDd,LVEDs and NT-pro BNP significantly decreased(P<0.01),and the LVEF level and 6min walking distance significantly increased in two groups(P<0.01).After treatment,the levels of LVEDd,LVEDs and NT-pro BNP in observation group were significantly lower than those in control group(P<0.01),and the LVEF level and 6min walking distance in observation group were significantly higher than those in control group(P<0.01).No severe adverse reaction occurred in two groups.The dry cough in 2 cases and headache in 3 cases in control group,and dizziness and headache in 5 cases and dizziness and nausea in 1 case in observation group were found,and the difference of the incidence of adverse reactions between two groups was not statistically significant(P>0.05).Conclusions: The carvedilol can obviously improve the inflammatory state and cardiac function of DCM patients,and there is not significant effect on blood lipid and blood glucose.
Effect of autologous arteriovenous fistula and long-term indwelling of deep venous catheter on the hemodialysis,cardiac function and renal anemia in MHD patients
AN Hui-liu, WANG Shi-jie
2021, 46(1): 39-43.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.011
[Abstract](0) [PDF 1057KB](0)
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Objective: To study the effects of autologous arteriovenous fistula and long-term indwelling of deep venous catheter on the hemodialysis,cardiac function and renal anemia in maintenance hemodialysis(MHD)patients.Methods: One hundred and twenty patients with MHD were randomly divided into the observation group and control group(60 cases in each group).The observation group was treated with autologous arteriovenous fistula for MHD,while the control group was treated with long-term indwelling of deep venous catheter.The therapeutic effects,dialysis adequacy,cardiac function,renal function,inflammatory reaction and complications were compared between two groups.Results: The total effective rate in observation group(83.33%)was significantly higher than that in control group(66.67%)(P<0.01),and the hemodialysis adequacy in observation group[(1.68±0.36)g/kg] was significantly higher than that in control group[(1.26±0.21)g/kg](P<0.01).The differences of the hemoglobin,glomerular filtration rate,left ventricular ejection fraction(LVEF),anterior and posterior left atrial diameter(LAD),right ventricular inner diameter(RVD),left ventricular end-diastolic volume(LVEDV),and inflammatory factor levels between two groups before treatment were not statistically significant(P>0.05).After treatment,the hemoglobin and glomerular filtration rate in observation group were significantly higher than those in control group(P<0.01).Compared with before treatment,the levels of LAD and LVEDV significantly increased,and the LVEF level significantly decreased in two groups after treatment(P<0.05 to P<0.01).After treatment,the level of LVEF in observation group was higher than that in control group,while the levels of LAD,RVD and LVEDV in observation group were lower than those in control group (P<0.01).After treatment,the levels of TNF-α,IL-6 and IL-8 in two groups significantly decreased compared with before treatment(P<0.01),and the above parameters in observation group were significantly lower than those in control group(P<0.01).The differences of the incidence rates of infection and renal anemia between two groups were not statistically significant(P>0.05),and the cardiovascular events in observation group was significantly lower than that in control group(P<0.05).Conclusions: Compared with the long-term indwelling of deep venous catheter,the effects of autologous arteriovenous fistula on dialysis in MHD patients is better,wich has less impact on cardiac function,and is worthy of promotion in clinic.
Clinical value of ultrasonic rinsing technique in the application of the one-time root canal therapy of pulpitis
ZHAO Shu-ling, DI Chun-lei, JIAO Zheng-kai
2021, 46(1): 44-45,49.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.012
[Abstract](0) [PDF 1013KB](0)
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Objective: To observe the clinical effects of the ultrasonic rinsing technique in the one-time root canal therapy for pulpitis patients.Methods: Four hundred and twelve teeth in 397 pulpitis patients were randomly divided into the observation group(205 teeth of 198 pulpitis patients)and control group(207 teeth of 199 pulpitis patients)randomly.The nickel titanium root canal in all patients were prepraed under local anesthesia,and the root canal in the observation group and control group were flushed with 2% sodium hypochlorite and 0.9% sodium chloride solution using ultrasonic oscillometer and 5 mL syringe,respectively.After flushing,all patients were filled with dry root tube thermocompression gel.The filling rate of lateral root canal,pain response after 1 week and curative effects after 1 year of treatment were recorded in two groups.Results: The filling rate of lateral root canal in observation group was significantly higher than that in control group(P<0.01).The incidence rate of pain in control group was significantly higher than that in observation group(P<0.01).There was no statistical significance in long-term clinical efficacy between two groups(P>0.05).Conclusions: The ultrasonic rinsing technique in the one-time root canal therapy of pulpitis can improve the filling rate of lateral root canal,reduce the pain response,and improve the curative effect of root canal treatment of patients.
Clinical study of pulmonary artery hypertension in patients with end-stage renal disease
CAO Lei
2021, 46(1): 46-49.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.013
[Abstract](0) [PDF 1037KB](0)
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Objective: To analyze the pulmonary artery pressure(PAP)of 128 end-stage renal disease(ESRD)patients treated with hemodialysis,investigate the occurrence of pulmonary artery hypertension(PAH)in patients with ESRD,and analyze the possible influencing factors of PAH.Methods: Among 128 ESRD patients,66 cases treated with hemodialysis and 62 cases without hemodialysis were divided into the observation group and control group,respectively.The PAH in two groups was evaluated by echocardiography,and the general data and echocardiographic results between two groups were compared.The observation group was subdivided into the non-PAH group and PAH group,the laboratory tests and cardiac ultrasound indicators were compared between two groups,and which was used to analyze the possible influencing factors of PAH.Results: The differences of the serum levels of creatinine,urea nitrogen,albumin,hemoglobin,blood calcium,blood phosphorus,25(OH)D,intact parathyroid hormone(iPTH),and PAP between the observation group and control group were statistically significant(P<0.05 to P<0.01).The incidence rate of PAH in observation group(33.3%)was higher than that in control group(17.7%)(P<0.05).The differences of the serum iPTH and hemodialysis time between PAH group and non-PAH group were statistically significant(P<0.05 and P<0.01).The differences of left atrial diameter,left ventricular end-diastolic diameter,left ventricular mass index and left ventricular ejection fraction between the PAH group and non-PAH group were statistically significant(P<0.05).The results of unconditional logistic regression analysis showed that the left ventricular end-diastolic diameter,left atrial diameter,left ventricular mass index,left ventricular ejection fraction and(iPTH)were correlated the with occurrence of PAH(P<0.05).Conclusions: PAH is common in patients with ESRD,and the incidence rate of which in long-term hemodialysis patients is higher,and the changes of left ventricular structure and function are closely related to PAH.
Effect of ultrasound-guided transverse abdominis plane block combined with lung protective ventilation management strategy on postoperative pulmonary complications in elderly patients treated with abdominal surgery under general anesthesia
WANG Juan, GU Er-wei, WANG Tao
2021, 46(1): 50-53.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.014
[Abstract](0) [PDF 1039KB](0)
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Objective: To investigate the effects of ultrasound-guided transverse abdominis plane block combined with lung protective pulmonary ventilation management strategy on postoperative pulmonary complications in elderly patients treated with abdominal surgery under general anesthesia.Methods: A total of 100 elderly patients treated with abdominal surgery under general anesthesia were randomly divided into the control group(group C) and group PT(treated with ultrasound transabdominal muscle plane block combined with lung protective ventilation strategy)(50 cases each in group).The incidence rates of postoperative pulmonary complications in two groups were observed and recorded.The tracheal extubation time,PACU residence time,postoperative gastrointestinal ventilation time,postoperative activity time out of bed,postoperative hospitalization time,anesthesia induction,intraoperative opioid dosage,and VAS scores after 6 h,12 h,24 h and 48 h of surgery were analyzed in two groups.Results: The incidence rate of postoperative pulmonary complications in group PT was lower than that in group C(P<0.01),the postoperative activity time out of bed and postoperative hospital stay in group PT were shorter than those in group C(P<0.05),and the intraoperative fentanyl dosage and VAS scores after 6 h and 12 h of operation in PT group were lower than those in group C(P<0.05 and P<0.01).The differences of the tracheal extubation time,PACU observation time,postoperative gastrointestinal ventilation time,anesthesia induction,intraoperative sufentanil dosage,and VAS scores after 24 h and 48 h of operation between two groups were not statistically significant(P>0.05).Conclusions: Transverse abdominis plane muscle block combined with lung protective ventilation management strategy can significantly reduce the incidence of postoperative pulmonary complications in elderly patients treated with abdominal surgery under general anesthesia.
Effect of stellate ganglion block-guided by ultrasound on tourniquet response in knee arthroplasty
CHEN Guang-hong, LI Jun-qing, ZHAO Yuan-yuan, LI Teng-fei, XI Wen-feng, Yuan Hao
2021, 46(1): 54-57.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.015
[Abstract](0) [PDF 1034KB](0)
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Objective: To study the effects of ultrasound-guided stellate ganglion block(SGB)on tourniquet response in knee arthroplasty.Methods: Sixty patients treated with unilateral knee arthroplasty were randomly divided into the group C and group E by random number table method.The group C and group E were treated with general anesthesia and SGB guided by ultrasound combined with general anesthesia.The heart rate(HR),systolic blood pressure(SBP),blood oxygen saturation(SpO2),EEG dual frequency index(BIS),anesthetic dosage,intraoperative blood loss,operation time,awake time,extubation time,postoperative sleep quality and postoperative complications were compared between two groups before tourniquet inflation(T0),after 30 min(T1)and 1 h(T2)of tourniquet inflation,before tourniquet deflation(T3),after 5 min(T4)and 30 min(T5)of tourniquet.Results: The differences of the HR,SBP,SpO2 and BIS at T0,T1,T2 and T5,the HR,SpO2 and BIS at T4,and the SpO2 at T3 were not statistically significant between two groups(P>0.05).The HR,SBP and BIS in C group at T3 were significantly higher than those in group E(P<0.05 to P<0.01).The anesthetic dosage,wake-up time,extubation time and postoperative sleep quality score in group C were significantly higher than those in group E(P<0.05),and the differences of the intraoperative blood loss and operation time between two groups were not statistically significant(P<0.05).The incidence rates of postoperative complication in group C and group E were 10.00% and 6.67,respectively,and the difference of which was not statistically significant(P>0.05).Conclusions: The SGB guided by ultrasound can reduce the tourniquet response in knee replacement surgery,thereby stabilizing the patient's hemodynamics,reducing the use of intraoperative narcotic analgesics,and not increasing adverse reactions.
Clinical efficacy of laparoscopic myomectomy and its influence on hormone index and inflammatory factor level
TANG Yong-rong, WANG Xi, ZHOU Xu-ru
2021, 46(1): 58-61.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.016
[Abstract](0) [PDF 1032KB](0)
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Objective: To investigate the clinical efficacy of laparoscopic myomectomy and its influence on hormone index and inflammatory factor level.Methods: Seven hundred and twenty patients with uterine myoma were randomly divided into the control group and observation group(360 cases in each group).The control group was treated with traditional laparotomy,and the observation group was treated with laparoscopic myomectomy.The levels of inflammatory factors,stress hormones and ovarian function indexes before and after treatment were compared between two groups.Results: The operative time,intraoperative blood loss,anal exhaust time,VAS score and length of hospital stay in observation group were significantly better than those in control group(P<0.01).There was no statistical significance in the levels of TNF-α,CRP,COR,NE,LH,FSH,E2 between two groups before operation(P>0.05).The levels of TNF-α,CRP,COR,NE,LH and FSH in two groups after operation significantly increased with compared which before operation,and which in observation group were lower than those in control group(P<0.01).The levels of E2 in two groups after operation significantly decreased compared with before operation,and which in observation group was significantly higher than that in control group(P<0.01).Conclusions: The clinical efficacy of laparoscopic myomectomy is good,which can effectively reduce inflammation and stress reaction,alleviate immunosuppression,reduce serum trauma reaction and improve ovarian function.
Role of serum neutrophil gelatinase-associated apolipoprotein in the assessment and diagnosis of coronary heart disease
LIU Yuan-you, ZENG Jin-cai, JIE Hai, LIU Yuan-bo
2021, 46(1): 61-64.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.017
[Abstract](0) [PDF 1049KB](0)
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Objective: To study the value of serum neutrophil gelatinase-associated apolipoprotein(NGAL)in assessing the severity of coronary atherosclerosis,and its diagnostic value in coronary heart disease.Methods: One hundred and thirty-five patients with coronary heart disease(CHD)diagnosed by coronary angiography and 30 patients without coronary heart disease diagnosed by coronary angiography were divided into the coronary heart disease group(CHD group),and control group(CON group).The CHD patients were subdivided into the stable angina pectoris group(SAP group),unstable angina pectoris group(UA group)and acute myocardial infarction group(AMI group).The clinical data,general biochemical indicators and serum high sensitive C-reactive protein hs-CRP level were compared among all groups.The correlations among NGAL,hs-CRP and Gensini score in all cases were analyzed.The value of serum NGAL in the diagnosis of coronary heart disease was analyzed by receiver operating(ROC)characteristic curve.Results: The serum levels of hs-CRP in SAP group,UA group and AMI group were higher than that in CON group(P<0.05),and the differences of hs-CRP level among SAP group,UA group and AMI group were statistically significant(P<0.05).The serum levels of NGAL and hs-CRP increased gradually with the increasing of Gensini score(P<0.01).The differences of serum levels of NGAL and hs-CRP were statistically significant among the Gensini score <30 group,30-60 group and >60 group(P<0.05~P<0.01).The serum level of NGAL was positively correlated with Gensini score and hs-CRP level(r=0.733,0.908,P<0.05),and the serum level of hs-CRP was positively correlated with Gensini score(r=0.708,P<0.05).The concentration of NGAL in CHD group was higher than that in CON group(P<0.05).When the cut-off value was 59.02 ng/mL,the area under ROC curve of serum NGAL in the diagnosis of coronary heart disease was 0.875,the 95%CI was 0.820-0.929,the sensitivity was 74.8%,and the specificity was 96.0%.Conclusions: The serum NGAL is correlated with the hs-CRP level and severity of coronary atherosclerosis,and can be used as an auxiliary index in the diagnosis of coronary heart disease.
Effect of the nimodipine combined with thymopentin in the treatment of HIBD, after intracerebral hemorrhage and its effects on serum levels of TLR4 and RBP4
XUE Fei, QIU Zhi-xiong, LU Kai
2021, 46(1): 65-67.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.018
[Abstract](0) [PDF 1021KB](0)
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Objective: To observe the effects of the nimodipine combined with thymopentin in the treatment of hypoxic-ischemic brain damage(HIBD)after intracerebral hemorrhage,and its effect on serum levels of Toll-like receptor 4(TLR4)and retinol binding protein 4(RBP4).Methods: Seventy-eight patients with HIBD after intra cerebral hemorrhage were randomly divided into the observation group and control group(39 cases in each group).The control group was treated with nimodipine,and the observation group was treated with nimodipine combined with thymopentin.The cerebral edema volume,intracranial pressure,national institutes of health stroke scale(NIHSS) score,Barthel index and cerebral hemodynamic index,and serum levels of TLR4 and RBP4 bewteen two groups were compared before and after 15 days of treatment.Results: Compared with before treatment,the cerebral edema volume,NIHSS score,Barthel index,intracranial pressure,and serum levels of TLR4 and RBP4 in two groups were significantly improved after treatment(P<0.05 to P<0.01),and the above indexes in observation group were better than that in control group(P<0.05 to P<0.01).After treatment,the hemodynamic indexes in observation group were significantly improved compared with those before treatment(P<0.01),and the difference of the hemodynamic indexes in control group were not statistically significant between before and after treatment(P>0.05).Conclusions: The nimodipine combined with thymopentin in the treatment of HIBD after intracerebral hemorrhage has good therapeutic effects,and can reduce the serum levels of TLR4 and RBP4,which is worthy of promotion.
Feasibility of bedside ultrasound monitoring the periodic variation rate of peak velocity of common carotid artery with positive pressure ventilation in the evaluation of the volume status of surgical ICU patients
CHEN Yao-wu, CHEN Yi-feng, MAO He-ming, HE Yao-wu, YANG Hong-mei, WU Zhong-yan, ZHOU Chao-yong
2021, 46(1): 68-70,75.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.019
[Abstract](0) [PDF 1260KB](0)
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Objective: To investigate the effects and feasibility of bedside ultrasound monitoring the periodic variation rate of peak velocity of common carotid artery with positive pressure ventilation in evaluating the volume status of surgical ICU patients.Methods: The capacity load in 50 surgical ICU patients treated with mechanical ventilation was tested.According to the added value of stroke volume(ΔSV)of the gold standard for assessing volumetric reactivity,the patients were divided into the reaction group(28 cases,rehydration capacity,ΔSV ≥15%)and non-reaction group(22 cases,rehydration capacity without reaction,ΔSV <15%).All patients were monitored using bedside ultrasound,the periodic variation rate of peak velocity of common carotid artery(ΔVpeak-CCA)was compared between two groups,and the correlation between ΔVpeak-CCA and ΔSV was analyzed.Results: There was no statistical significance in SV between two groups before and after the expansion(P>0.05),the ΔSV and ΔVpeak-CCA in reaction group were significantly higher than those in non-reaction group(P<0.05),and the Vpeak-max and Vpeak-min in reaction group were lower than those in non-reaction group(P<0.05).The ΔSV of surgical ICU patients was positively correlated with the ΔVpeak-CCA(r=0.862,P<0.05).The area under the ΔVpeak-CCA ROC curve was 0.846,the diagnostic threshold of ΔVpeak-CCA was 12.36%,the sensitivity was 93.48%,and the specificity was 81.09%.Conclusions: The bedside ultrasound monitoring the periodic variation rate of peak velocity of common carotid artery with positive pressure ventilation in evaluating the volume status of surgical ICU patients is effective and feasible.It can provide a basis for physicians to analyze the patients' condition,and is worthy of popularization.
The value of AMH combined with FSH detection in the evaluation of ovarian reserve function in elderly women scheduled by assisted reproductive technology
PAN Wei-jun, YE Xi-ping, HUANG Cun, AI Feng-lian
2021, 46(1): 71-75.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.020
[Abstract](0) [PDF 1072KB](0)
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Objective: To investigate the value of anti-Miillerian hormone(AMH) combined with follicle stimulating hormone(FSH) in the evaluation of ovarian reserve function in elderly women scheduled by assisted reproductive technology.Methods: The clinical data of 139 elderly patients(aged >35 years old) scheduled by assisted reproductive technology were retrospectively analyzed.According to the 2017 Poseidon poor ovarian response grouping criteria and ovarian reserve function test results,the patients were divided into normal group(n=51),diminished ovarian reserve(DOR) group(n=46) and premature ovarian failure(POF) group(n=42).According to the success of pregnancy within 1 year,the normal group was subdivided into the pregnant group(n=37) and non-pregnant group(n=14).The ovarian function-related assessment indexes were compared among all groups.The receiver operating characteristic curve(ROC) was used to evaluate the value of age,AMH and FSH alone or combined in the diagnosis of ovarian reserve dysfunction.Results: The age,FSH and LH in DOR and POF groups were significantly higher than those in normal group,while the AMH,AFC and E2 were significantly lower than those in normal group(P<0.01).The age,FSH and LH in POF group were higher than those in DOR group,and the AMH,AFC and E2 in POF group were lower than those in DOR group(P<0.05 to P<0.01).The differences of the levels of PRL and P among three groups were not statistically significant(P>0.05).The results of correlation analysis showed that the AMH was positively correlated with AFC and E2(P<0.01),and negatively correlated with the age,FSH and LH(P<0.01).The FSH was positively correlated with age and LH(P<0.01 and P<0.05),and negatively correlated with AFC and E2(P<0.01).There was not significant correlation among AMH,FSH,PRL and P(P>0.05).The critical values of age,AMH and FSH in the diagnosis of ovarian reserve dysfunction were 36.25 years old,1.27 ng/mL and 8.11 U/L,respectively.The AUC value,sensitivity,specificity,PPV and NPV of three combination detection in the diagnosis of ovarian reserve dysfunction were 0.932,93.18%,94.11%,96.47%,88.89% and 96.59%,respectively,which were higher than those of single detection(P<0.05).The levels of AMH and E2 in pregnant group were significantly higher than those in non-pregnant group(P<0.01 and P<0.05),while the levels of FSH and LH in pregnant group were significantly lower than those in non-pregnant group(P<0.01).Conclusions: The AMH and FSH are the effective indexes to evaluate the ovarian reserve function in elderly patients scheduled by assisted reproductive technology.The AMH combined with FSH detection technology can effectively replace the traditional evaluation system of ovarian reserve function.
Analysis of the risk factors of screw perforating humerus head after internal fixation in 125 patients with proximal humerus fractures
HEI Jin-xuan
2021, 46(1): 76-79.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.021
[Abstract](0) [PDF 1025KB](0)
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Objective: To analyze the incidence and risk factors of screw perforating humeru after internal fixation in patients with proximal humerus fractures.Methods: The clinical data of 125 patients treated with open reduction-internal fixation with locking plates were analyzed.The patients were divided into two groups according to whether screw perforation.Among 125 cases,18 patients with screw perforation and 107 patients without screw perforation were found.The risk factors of screw perforation in patients with proximal humerus fractures after internal fixation were analyzed.Results: The incidence rate of screw perforation in patients with proximal humeral fractures after internal fixation was 14.4%(18/125).The results of univariate analysis showed that the probability of screw perforation in patients with proximal humerus fractures complicated with medial column crushing,higher Neer type,medial column support,fewer screws and poor reduction after internal fixation were higher(P<0.05 to P<0.01).The results of multivariate logistic regression analysis showed that the Neer type,medial column crushing and poor reduction were the independent influencing factors of screw perforation after internal fixation in patients with proximal humeral fractures(P<0.01).Conclusions: The probability of screw perforation in patients with proximal humerus fractures complicated with medial column crushing,high Neer type and poor reduction is high.Clinically,some measures should be taken to strengthen the fracture stability and increase the humeral head support,so as to reduce the risk of screw perforation and improve the treatment effect of patients.
Comparison of the value between ultrasound-guided breast rototomy and open surgery in the treatment of benign breast masses
PENG Guang-sheng, CHEN Yi
2021, 46(1): 80-82.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.022
[Abstract](0) [PDF 1008KB](0)
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Objective: To explore the value of ultrasound-guided breast rototomy and open surgery in the treatment of benign breast masses,and precautions of breast rototomy.Methods: One hundred and twenty benign breast mass cases treated with ultrasound-guided breast rototomy and 125 benign breast mass cases treated with open surgery were divided into the observation group and control group,respectively.The operation time,intraoperative bleeding,postoperative complications,scar length and patient satisfaction were compared between two groups.Results: The intraoperative blood loss,operation time,length of postoperative scar and length of hospital stay in observation group were significantly lower than those in control group(P<0.05 to P<0.01),and the difference of the resection rate of mass between two groups was not statistically significant(P>0.05).The incidence rate of postoperative complications in observation group(3.33%) was significantly lower than that in control group(11.20%)(P<0.01).The results of postoperative following-up showed that the satisfaction with the appearance of breast in observation group(94.17%) was significantly higher than that in control group (85.00%)(P<0.01).Conclusions: Compared with the open surgery,the ultrasound-guided breast rototomy has the advantage of minimally invasive treatment,and higher application value in the treatment of benign breast masses.
Investigation on the control status of bronchial asthma in children aged 6-12 years
GAN Hong-hong
2021, 46(1): 83-86,90.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.023
[Abstract](0) [PDF 1047KB](0)
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Objective: To understand the treatment and control status of children with bronchial asthma aged 6-12 years,and their parents' cognition and implementation of GINA program.Methods: The children aged 6-12 years with bronchial asthma in emergency department from March 2017 to September 2018 were investigated.The questionnaires were filled out and collected through one-to-one and face-to-face,and the data were statistically analyzed.Results: Among 134 cases,the good control of disease accounted for 16.4%(22/134),partial control of disease accounted for 47.0%(63/134),and no control of disease accounted for 36.6%(49/134).Among the control treatment,the patients with standard treatment accounted for 16.7%(21/134),and the patients without standard treatment accounted for 83.3%(113/134)(including 66.4% of patients without any treatment).The asthma control effect and satisfaction with treatment plan in standard treatment group were significantly better than those in non-ICS standard treatment group(P<0.01).Only 56.0% of parents of asthmatic children knew that the asthma needed long-term control and treatment,80.6% of patients knew that glucocorticoids could be used to control asthma treatment,and 80.9% of parents of asthmatic children were willing to accept the prevention and treatment knowledge of asthma from online or WeChat platform.Conclusions: The current situation of control asthma in children aged 6-12 years is still not ideal,and the parents' understanding of asthma and standard treatment is low.The awareness and attention of asthma in paediatrics and general practitioners should be strengthened.Improving the level of diagnosis and treatment,strengthening the publicity and education of families of children with asthma,and further using the internet platform to manage and educate children with asthma should be implemented.
Analysis of the risk factors of tumor recurrence in hepatocellular carcinoma patients with positive microvascular invasion treated with hepatectomy
SU Zhan, YANG Wei-zhong, CHE Jin-hui, ZHOU Wu-yuan
2021, 46(1): 87-90.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.024
[Abstract](0) [PDF 1037KB](0)
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Objective: To study the risk factors for tumor recurrence in hepatocellular carcinoma patients with positive microvascular invasion(MVI) treated with hepatectomy.Methods: Sixty patients with liver cancer were divided into the MVI-positive group(20 cases) and MVI-negative group(40 cases) according to the surgical pathological results.The basic data,postoperative complications,and recurrence rate and mortality after 12-month of following-up were compared between two groups.The risk factors of tumor recurrence in hepatocellular carcinoma patients with positive MVI treated with hepatectomy were analyzed.Results: The differences of the gender,age,pathological type,surgical margin,anatomical hepatectomy,cirrhosis,hepatitis and liver function Child-Pugh classification between two groups were not statistically significant(P>0.05).The differences of the degree of tumor differentiation,maximum diameter of tumor,smooth edge of tumor,integrity of tumor envelope and level of α-fetoprotein(AFP) were statistically significant(P<0.05 to P<0.01).The postoperative complication rate in the MVI-positive group and MVI-negative group were 20.00% and 7.50%,respectively,and the difference of which between two groups was not statistically significant(P>0.05).After 12 months of following-up,the recurrence rate of tumor in MVI-positive group(25.00%) was higher that in MVI-negative group(5.00%)(P<0.05).The difference of the mortality rate between the MVI-positive group(10.00%) and MVI-negative group(5.00%) was not statistically significant(P>0.05).The results of multivariate logistic regression analysis showed that the low differentiation,maximum diameter >5 cm,non-smooth edge,tumor-free capsule and AFP>400 g/L were the dependent risk factors of MVI-positive liver cancer(P<0.05 to P<0.01).Conclusions: The recurrence rate of MVI-positive liver cancer patients after hepatectomy is higher than that of MVI-negative liver cancer patients,and mainly related to the degree of tumor differentiation,tumor diameter,tumor margin,capsule and AFP level.
Mediating effect of inter-interpersonal emotional regulation in conscientiousness and team emotional intelligence based on structural equation and Bootstrap method
ZHOU Xue-fei, SUN Xue-qin, YUAN Juan
2021, 46(1): 91-94.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.025
[Abstract](0) [PDF 1604KB](0)
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Objective: To investigate the influence of the interpersonal emotion regulation and conscientiousness on team emotional intelligence.Methods: A total of 731 college students were investigated using the conscientiousness subscale of personality questionnaire,team emotional intelligence scale and leadership positive emotional operation questionnaire.Results: The overall level of college students' team emotional intelligence was general,the team emotional intelligence was positively correlated with conscientiousness(P<0.01),and the emotional interaction of leaders was positively correlated with conscientiousness and team emotional intelligence(P<0.01).The conscientiousness influenced the team emotional intelligence through the partial mediating effect of leadership positive emotional interaction(P<0.01).The indirect effect accounted for 64.22% of the total effect.Conclusions: The interpersonal positive emotion regulation plays a partial mediating role between conscientiousness and team emotional intelligence.
The correlation between the basic psychological need satisfaction of the elderly and physical exercise behavior based on the perspective of “self-determination theory”
WEI Jiao-jiao, XIE Hui, WANG Chen-chen, LIU Cheng-xiang
2021, 46(1): 95-101.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.026
[Abstract](0) [PDF 1076KB](0)
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Objective: To analyze the correlation between the basic psychological need satisfaction and physical exercise behavior in the elderly,and provide reference for promoting the elderly health behavior.Methods: A total of 460 elderly people were selected using cluster sampling method.The demographic and sociological data,basic psychological need satisfaction and physical exercise behavior in the elderly were investigated using the general questionnaire,basic psychological need satisfaction scale and physical activity scale.Results: The physical exercise of the elderly mostly concentrated in the small amount of exercise and low intensity exercise.The differences of the basic psychological need satisfaction and physical exercise behavior among the elderly with different gender,registered residence type,education level,occupation and monthly income were statistically significant(P<0.05 to P<0.01).The basic psychological need satisfaction of the elderly was positively correlated with exercise behavior(P<0.01).Conclusions: Meeting the basic psychological needs of the elderly can promote the more active participation in physical exercise.The appropriate improving the intensity of exercise of the elderly can develop a healthy and effective way of exercise,which is conducive to the health of the elderly.
Prevalence of metabolic syndrome under four different diagnostic criteria
ZHOU Hui-yun, WANG Jing, LI Xiu-chuan, LEI Ting-ting, WANG Lei
2021, 46(1): 102-107.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.027
[Abstract](0) [PDF 1086KB](0)
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Objective: To analyze prevalence differences of metabolic syndrome(MetS) based on the four criteria(CDS2013,JIS,IDF,and ATP Ⅲ).Methods: Data were collected from healthy examinees in a hospital physical examination center,including physical examination data and laboratory examination data.Kappa test was used to compare the consistency of the four diagnostic criteria.Results: The prevalence rate was the highest under JIS criterion(26.6% ),followed by ATP Ⅲ criterion(25.8%),IDF criterion(20.3%)and CDS criterion(19.3%).With the increase of age,the prevalence of MetS was increasing under the four diagnostis criteria.Among the four diagnostic criteria,the highest detection rate of MetS was hypertension,followed by central obesity,and the lowest was low-density lipoprotein.The consistency was the highest under JIS and ATP Ⅲ criterion.Conclusions: The prevalence of MetS was different among the four diagnostic criteria.It is necessary to increase the awareness of prevention for male and elderly people,especially for the high-risk groups of hypertension and obesity,health education should be strengthened.
Dietary investigation and analysis of the diabetic kidney disease and chronic kidney disease patients complicated with diabetes mellitus
ZHOU Zi-qi, LIU Yuan, CAI Qian, ZENG Xiao-qing, FU Ping, HU Wen
2021, 46(1): 107-110.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.028
[Abstract](0) [PDF 1035KB](0)
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Objective: To investigate the dietary intake in patients with diabetic kidney disease(DKD)and patients with chronic kidney disease(CKD)complicated with diabetes,and provide the direction for further nutritional therapy.Methods: The dietary survey was implemented using 3-day 24 h dietary review method.The nutrient intake in 93 patients with DKD and CKD complicated with diabetes were calculated using food composition table,and which was compared with China health industry standard(WS/T 557-2017) recommended dietary requirements for CKD patients.Results: The actual protein intake in the population was lower than that of recommended amount(P<0.01).The proportion of high-quality protein intake was significantly higher than that of the recommended value(P<0.01),and the difference between energy intake and recommended amount was not statistically significant(P>0.05).There was no statistical significance in the nutritional intake of patients with different genders(P>0.05),the difference of the proportion of high-quality protein intake among patients with different CKD stages were statistically significant(P<0.05),and the difference of protein intake between dialysis and non-dialysis patients was statistically significant(P<0.05).The protein intake in patients with different genders,CKD stages and dialysis status were significantly lower than those of recommended value(P<0.01).The proportion of high-quality protein intake in patients with different genders,dialysis status and CKD stage 4 and 5 were significantly higher than that of recommended value(P<0.01),and the difference between the proportion of high-quality protein intake and recommended value in patients with CKD stage 3 was not statistically significant(P>0.05).Conclusions: The protein intake of(DKD patients and CKD patients complicated with diabetes are lower than that of recommended amount of the guideline.There are differences in protein intake among patients with different CKD stages and with or without dialysis.The nutrition education should be strengthened and individualized dietary guidance in combination with disease stage and treatment status.
Study on the differences of the professional attitude in male and female nursing students and its influencing factors
HU Man-man, QIAN Zhi-gang
2021, 46(1): 111-114,119.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.029
[Abstract](0) [PDF 1046KB](0)
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Objective: To understand the professional attitude of male and female nursing students,and grasp the difference of the influencing factors of professional attitude between male and female nursing students.Methods: The male and female students from a medical college were selected using the conditions sampling and convenience sampling,respectively.All students were investigated.Results: The score of professional attitude of nursing students was (4.34±0.65)points,the professional attitude score of male and female nursing students were (4.29±0.71)points and (4.36±0.63)points,respectively,the difference of which between male and female students was not statistically significant(P>0.05),and the differences of professional attitude of nursing students among different grade,family residence,professional choice motivation,vocational interest and vocational choice were statistically significant(P<0.05 to P<0.01).The results of logistic regression analysis showed that the family residence,professional choice motivation,profession interest and profession choice were the independent influencing factors of nursing students' professional attitude(P<0.01).Among the gender in the factors influencing the professional attitude of nursing students,the differences of attitude of family members,attitude of students of this major and other majors,attitude of schools and their own identification with the major were statistically significant(P<0.05 to P<0.01).Conclusions: The professional attitude in male and female nursing students are negative and lack of professional interest.The family residence,and willingness and interest of nursing students affect their professional attitude.The difference of gender in the influence factors of nursing students' professional attitude is deeply,and influenced by the traditional social concepts,so schools and nursing educators should pay more attention to it.
Effect of the self-management support based on mobile phone APP on the self-efficacy and psychological distress of young and middle-aged diabetic patients
KANG Shuo, ZHAO Xiu-jun, GAO Jun-xiang, TIAN Su-zhai, QIU Jing-jing, WANG Zhu-ning, ZHANG Li-hui
2021, 46(1): 115-119.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.030
[Abstract](0) [PDF 1047KB](0)
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Objective: To explore the effects of the self-management support based on mobile phone APP on the self-efficacy,psychological distress,blood glucose and glycosylated hemoglobin in young and middle-aged diabetic patients.Methods: A total of 100 young and middle-aged diabetic patients from department of endocrinology in a grade A general hospital in Hebei province were selected using convenience sampling method,and randomly divided into the control group(50 cases) and observation group(50 cases).The control group was nursed with routine care,the observation group was nursed with 6-month self-management support based on mobile phone APP.Before and after 6 months of intervention,the self-efficacy and psychological distress were evaluted,and the levels of blood glucose and glycosylated hemoglobin were measured in two groups.Results: Before intervention,there was no statistical significance in the scores of self-efficacy scale and diabetes distress scale,and levels of blood glucose and glycosylated hemoglobin between two groups(P>0.05).After 6 months of intervention,the scores of self-efficacy scale and diabetes distress scale,and levels of blood glucose and glycosylated hemoglobin in observation group were significantly better than those in control group(P<0.01).Conclusions: The self-management support based on mobile phone APP can improve self-efficacy and psychological dsitress,promote the indexes of blood glucose and glycosylated hemoglobin reaching to standard.
Analysis of quality of life status and its influencing factors in maintenance hemodialysis patients
ZHAI Cong-fang, YIN Jian-hua, CHEN Ying
2021, 46(1): 120-123.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.031
[Abstract](0) [PDF 1017KB](0)
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Objective: To analyze the influencing factors of quality of life in maintenance hemodialysis patients.Methods: The general and clinical data of 88 patients treated with maintenance hemodialysis were collected,and the SF-36 scale scores of the patients with different age,gender,marital status,educational level,working status,family per capita monthly income,payment method of medical expense,sleep condition and condition of complicated diseases were compared.The factors with statistical significance were set as the independent variables,the score of SF-36 scale was set as the dependent variable,and the factors affecting the quality of life of maintenance hemodialysis patients were screened using multiple linear regression analysis.Results: The results of single factor analysis showed that the differences of the total scores of physical health and mental health among the patients with different ages,marital status,educational level,family per capita monthly income,work status and sleep quality were statistically significant(P<0.01),and the total scores of the physical health and mental health in patients complicated with diabetes mellitus,hypertension,heart disease and respiratory disease were significantly lower than those in patients complicated without the above diseases(P<0.01).The results of multiple linear regression analysis showed that the age,family per capita monthly income,sleep quality,diabetes,hypertension mellitus,heart disease and respiratory disease were the independent influencing factors of total scores of physical health and mental health score of SF-36 scale(P<0.05).Conclusions: The age,income,sleep and complicated diseases were the influencing factors of quality of life in maintenance hemodialysis patients.
Correlation between protection motivation and healthy behavior in high risk patients with stroke
DENG Li-ping, XIE Xiao-hua, WANG Ya-ping, YANG Jie, PAN Lu, MA Jia-hui, XIAO Jing-yi, XIONG Xiao-yun
2021, 46(1): 124-128.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.032
[Abstract](0) [PDF 1058KB](0)
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Objective: To investigate the relationship between protection motivation and healthy behavior in high risk patients with stroke.Methods: A total of 121 patients with high-risk stroke,who were screened and followed up in the stroke nursing clinic,were selected as the study objects using the convenient sampling method.The general data questionnaire,protection motivation questionnaire(PMQ-SHRP)and stroke health behavior scale(HBS-SP)were used to investigate the protection motivation and healthy behavior of the high-risk population,and the relationship between protection motivation and healthy behavior was analyzed.Results: The total score of protection motivation was(184.38±14.25)points,and the average score of items was(3.76±0.29)points.The total score of healthy behavior was(76.93±10.46)points,and the average score of items was(3.08±0.42)points.The protection motivation was positively correlatied with healthy behavior(P<0.01).The internal and external rewards,response costs and self-efficacy dimensions of protection motivation were positively correlated with healthy behavior(P<0.01).Conclusions: Improving the awareness of the severity,susceptibility and response efficiency of stroke high-risk population can reduce the internal and external rewards and response costs,and enhance self-efficacy to promote the protection motivation and establish healthy behaviors.
Effect of the body weight management on pregnant woman labor and delivery outcome
TAN Qiong
2021, 46(1): 128-130.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.033
[Abstract](0) [PDF 1006KB](0)
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Objective: To explore the effects of body weight management on pregnant woman labor and delivery outcome.Methods: One hundred puerperas were divided into the body weight management group and control group according to the management method(50 cases in each group).The control group was dealed with traditional management method,and the body weight management group were dealed with weight management during pregnancy.The delivery methods,perineal injury,duration of labor and adverse events were compared bewteen two groups.Results: The cesarean delivery rate and natural delivery rate in body weight management group were lower and higher than that in control group,respectively(P<0.05).There were 75 cases of vaginal delivery in two groups,and the degree of vaginal damage in body weight management group was significantly lower than that in control group(P<0.01).The first,second,third and total duration of labor in body weight management group were significantly shorter than those in control group(P<0.05 to P<0.01).And the incidence rate of adverse pregnancy events in body weight management group was significantly lower than that in control group(P<0.01).Conclusions: Body weight management during pregnancy can shorten the duration of labor,increase the rate of natural delivery,and reduce the incidence rate of adverse pregnancy events.
Analysis on the oral health knowledge,attitude and behavior of college students in Anhui medical college
WU Jun-jie, LIAO Sheng-kai, HAN Qian-qian, JIANG Sheng, XU Zhi-jia, LU Tong, SONG Chi
2021, 46(1): 131-136.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.034
[Abstract](0) [PDF 1053KB](0)
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Objective: To investigate the oral health knowledge,attitude and behavior of medical students from five medical colleges in Anhui to provide the scientific reference for the intervention of the oral health of college students.Methods: The oral health knowledge,attitude and behavior of 1419 medical students from five medical colleges in Anhui were investigated using questionnaire.Results: The results of the questionnaire survey showed that the awareness rate of oral knowledge among Anhui medical college students was low.Except that the awareness rate of "fluoride can increase the anti-acid ability of teeth" was 79.42%(1 127/1419),and the awareness rate of "acidic substance is the main cause of dental plaque" was 63.78%(905/1 419),the awareness rate of other knowledge was less than 60%.Among the college students,the 68.50%(972/1 419)students considered that the oral education was necessary,and 70.26%(997/1 419)students considered that the minor diseases existed in their oral health evaluation.The media(57.15%),books(54.62%)and knowledge brochures(51.16%)were the main approaches for college students to acquire oral knowledge.The awareness rates of the oral knowledge of "fluoride can increase the anti-acid ability of teeth;tea is the drink with the highest fluoride content;dental floss can effectively clear the tooth space;drinking water is the main source of fluoride intake" in female students were higher than those in male students(P<0.05 to P<0.01).The knowledge,attitude and behavior of wisdom teeth in female students were better than those in male students(P<0.01).The difference of the oral health education in college students from different places of origin was statistically significant(P<0.01),and the differences of the necessity of oral health examination,the benefits of electric toothbrush for oral health,purpose of brushing and willingness to receive oral education were statistically significant(P<0.01).Conclusions: The overall evaluation of oral health knowledge,attitude and behavior among medical students in Anhui is not satisfied enough.The oral health education among colleges should be enhanced to help college students to improve the awareness of oral health and develop good oral cleaning habits.
2021, 46(1): 137-139.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.035
[Abstract](0) [PDF 992KB](0)
Abstract:
2021, 46(1): 139-140.   doi: 10.13898/j.cnki.issn.1000-2200.2021.01.036
[Abstract](0) [PDF 1356KB](0)
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