The value of the combined detection of serum CEA, CYFRA21-1,NSEand CA724 in the diagnosis of lung cancer
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1. Department of Nuclear Medicine;
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2. Department of Respiratory Medicine, The Chaohu Hospital Affiliated to Anhui Medical University, Chaohu Anhui 238000, China
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Received Date:
2012-05-06
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Abstract
Objective:To investigate the value of the combined detection of carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),neuron specific enolase(NSE) and carcinoembryonic antigen 72-4(CA724) in the diagnosis of lung cancer.Methods:The serum levels of CEA,CYFRA21-1,NSE,CA724 in 56 cases with lung cancer(24 cases with adenocarcinoma,20 cases with squamous cell carinoma and 24 cases with small cell carcinoma),34 cases with benign pulmonary diseases and 30 healthy people were detected and analysed using electrochemiluminescence.Results:The differences of the serum levels of CEA,CYFRA21-1,NSE and CA724 in five groups were statistical significant(P0.01).The levels of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group and NSE in small cell carcinoma group were significantly higher than those in other groups(P0.01).The level of CA724 in adenocarcinoma group was significantly higher than that in control group and benign disease group(P0.01).The positive rates of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group,NSE in small cell carcinoma group and CA724 in adenocarcinoma group were higher than those in control group and benign disease group(P0.05 to P0.01).The specificities and sensitivities of the individual detection of 4 kinds of markers were 88.9% to 94.4% and 28.6% to 41.1%,respectively.The specificity and sensitivity of the combined detection of 4 kinds of markers decreased(83.3%) and increased(87.5%),respectively.Conclusions:There is certain correlation between the serum levels of CEA,CYFRA21-1,NSE and CA724 and the pathological type of lung cancer,the combined detection of which can improve the postive detection rate of lung cancer.
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References
|
[2] 朱国民，马兰.血清VEGF、CEA及CA724联合检测对胃癌诊断预后的临床意义[J].现代检验医学杂志，2007,22(6)：83-85. |
|
[2]
|
何萍，董碧蓉.肿瘤标志物在肺癌临床中的应用价值[J].临床内科杂志，2005，22(6)：430-432. |
|
[3] Molina R，Filella X，Ange JM，et al.Tumor markers(CEA,CA125,CYFRA21-1,SCC AND NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis.Comparison with the main clinical and pathological prognostic factors[J].Tumour Biol,2003,24(6):205-209. |
|
[4] 董林，王磊，张元英，等.CA125、NSE联检在肺癌诊断中的价值[J].放射免疫学杂志，2009,22(1)：38-39. |
|
[5] 杨琦，袁媛，孙伟莉，等.CA125、CA724联合检测在卵巢癌诊断中的应用[J].皖南医学院学报，2010,29(4)：284-285. |
|
[6] 丁燕玲，赵应斌，容元，等.187例恶性肿瘤患者CA724增高结果分析[J].检验医学与临床，2010,7(15)：1548-1551. |
|
[7] 王国洪，万文微，刘波，等.四种肿瘤标志物检测非小细胞肺癌的临床应用研究[J].中华检验医学杂志，2003,26(8):491-494. |
|
[8] Sung HJ,Cho JY.Biomarkers for the lung cancer diagnosis and their advances in proteomics [J].BMB Rep，2008,41(9):615-625. |
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