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2014 Vol. 39, No. 4
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2014, 38(4): 426-428,432.
Abstract:
Objective:To compare the characteristics and differences of peripheral blood T cells stimulated by HDMAPP,Mycobacterium tuberculosis heat-resistant antigen(Mtb-HAg) and low molecular peptide antigen of Mycobacterium tuberculosis(Mtb)(10 k) to produce interferon(IFN-).Methods:The peripheral blood cells from healthy adults were cultured with HDMAPP and Mtb-HAg and Mtb-HAg(10k) for 14 hours,then added Monensin to cultivate for another 6 hours.Cells were collected,and the surface molecule and intracellular cytokines were stained with different fluorochrome-conjugated mAbs.The expressions of IFN- in CD3+ and CD3+ cells of different experiment group were detected by flow cytometry.Results:The ratios of CD3+ and CD3+ cells to produce IFN- in all antigen experiment groups were higher than that in control group(P0.01).The ratios of CD3+ cells to produce IFN- in all antigen experiment groups were significantly higher than that of CD3+ cells(P0.05 to P0.01).The differences of CD3+ cells and CD3+ cells in three kinds of antigenic stimulation groups were not statistical significance(P0.05).Conclusions:CD3+ cells and CD3+ cells can produce IFN- by stimulating the peripheral blood T cells with HDMAPP,Mtb-HAg and Mtb-HAg(10k).CD3+ cells stimulated by three kinds of antigens can produce IFN-.The IFN- level in CD3+ cells stimulated by HDMAPP and Mtb-HAg(10 k) is higher than that of Mtb-HAg stimulating.
Objective:To compare the characteristics and differences of peripheral blood T cells stimulated by HDMAPP,Mycobacterium tuberculosis heat-resistant antigen(Mtb-HAg) and low molecular peptide antigen of Mycobacterium tuberculosis(Mtb)(10 k) to produce interferon(IFN-).Methods:The peripheral blood cells from healthy adults were cultured with HDMAPP and Mtb-HAg and Mtb-HAg(10k) for 14 hours,then added Monensin to cultivate for another 6 hours.Cells were collected,and the surface molecule and intracellular cytokines were stained with different fluorochrome-conjugated mAbs.The expressions of IFN- in CD3+ and CD3+ cells of different experiment group were detected by flow cytometry.Results:The ratios of CD3+ and CD3+ cells to produce IFN- in all antigen experiment groups were higher than that in control group(P0.01).The ratios of CD3+ cells to produce IFN- in all antigen experiment groups were significantly higher than that of CD3+ cells(P0.05 to P0.01).The differences of CD3+ cells and CD3+ cells in three kinds of antigenic stimulation groups were not statistical significance(P0.05).Conclusions:CD3+ cells and CD3+ cells can produce IFN- by stimulating the peripheral blood T cells with HDMAPP,Mtb-HAg and Mtb-HAg(10k).CD3+ cells stimulated by three kinds of antigens can produce IFN-.The IFN- level in CD3+ cells stimulated by HDMAPP and Mtb-HAg(10 k) is higher than that of Mtb-HAg stimulating.
2014, 38(4): 429-432.
Abstract:
Objective:To explore the anti-inflammatory effects of punicosides(Puns) and its mechanism.Methods:Two kinds of acute inflammation model of mouse(including ear swelling in mice induced by dimethylbenzene and paw swelling in rats induced by carageen glue) were established,animals were divide into model control group,Puns treatment group and Indomethacin group.The inhibiting effects of Puns on mice with ear swelling induced by dimethylbenzene and rats with paw swelling induced by carageen glue were observed.The levels of the prostaglandin E2(PGE2) and methane dicarboxylic aldehyde(MDA) in rat paw and superoxide dismutase(SOD) and MDA in serum were measured in Puns treatment groups.Results:The 400 and 800 mg/kg of Puns could significantly suppress the mice ear swelling induced by dimethylbenzene(P＜0.05 and P＜0.01),Puns could suppress the rats paw swelling induced by carageen glue in different extents(P＜0.05 to P＜0.01).Compared with model control group,Puns significantly inhibited the production of PGE2 and MDA of inflammatory tissue(P0.01),increased the activity of serum SOD,and decreased the level of serum MDA,the differences of which were statistical significance(P＜0.05 to P＜0.01).Conclusions:Puns has anti-inflammatory effects,which may be related to the inhibition of PGE2 synthesis and anti-lipid peroxidation.
Objective:To explore the anti-inflammatory effects of punicosides(Puns) and its mechanism.Methods:Two kinds of acute inflammation model of mouse(including ear swelling in mice induced by dimethylbenzene and paw swelling in rats induced by carageen glue) were established,animals were divide into model control group,Puns treatment group and Indomethacin group.The inhibiting effects of Puns on mice with ear swelling induced by dimethylbenzene and rats with paw swelling induced by carageen glue were observed.The levels of the prostaglandin E2(PGE2) and methane dicarboxylic aldehyde(MDA) in rat paw and superoxide dismutase(SOD) and MDA in serum were measured in Puns treatment groups.Results:The 400 and 800 mg/kg of Puns could significantly suppress the mice ear swelling induced by dimethylbenzene(P＜0.05 and P＜0.01),Puns could suppress the rats paw swelling induced by carageen glue in different extents(P＜0.05 to P＜0.01).Compared with model control group,Puns significantly inhibited the production of PGE2 and MDA of inflammatory tissue(P0.01),increased the activity of serum SOD,and decreased the level of serum MDA,the differences of which were statistical significance(P＜0.05 to P＜0.01).Conclusions:Puns has anti-inflammatory effects,which may be related to the inhibition of PGE2 synthesis and anti-lipid peroxidation.
2014, 38(4): 433-437.
Abstract:
Objective:To explore the feasibility of antisense oligodeoxynucleotide(ASODN) targeting 1integrin gene for treatment of human ovarian cancer in nude mice.Methods:Routinely cultured SKOV3 cells were subcutaneously implanted in the nude mice to establish xenograft animal model.The 32 tumor-bearing mice were randomly divided into ASODN group(A group),ASODN combined with DDP group(A+D group),DDP group and physiological saline control group(NS group)(n=8 in each ).Drug treatment was started after randomization.After 1integrin ASODN mediated by cytofectin was directly injected into the xenograft,the volume and weight of the tumor mass were detected,and then the tumor growth inhibitory rate was calculated.Reverse transcription-polymerase chain reaction(RT-PCR) and immunochemohistology assay were used to detect the expression level of 1integrin mRNA.Results:In the A group,the tumor volume and tumor anticancer efficacy were(316.1021.77) mm3 and 48.15%,respectively.The tumor growth inhibitory rate and tumor volume were significantly different between the NS group and the A group(P0.01).In the A+D group,the tumor volume reduced to (178.7040.67)mm3 and the tumor anticancer efficacy was enhanced to 70.37%,which were significantly different compared with those of the DDP group and other controls(P0.05 to P0.01).Significant down-regulation of 1integrin mRNA expression in the tumor tissues of the A group and A+D group was detected by RT-PCR and immunochemohistology assay(P0.01).Conclusions:Singly use of 1integrin ASODN or combined with DDP can effectively inhibit the growth of human ovarian carcinoma xenograft in nude mice by direct intra-tumoral injection.The anticancer efficacy may be associated with the down regulation of 1integrin expression.ASODN targeting 1integrin gene can be a supportive therapy to the ovarian cancer.
Objective:To explore the feasibility of antisense oligodeoxynucleotide(ASODN) targeting 1integrin gene for treatment of human ovarian cancer in nude mice.Methods:Routinely cultured SKOV3 cells were subcutaneously implanted in the nude mice to establish xenograft animal model.The 32 tumor-bearing mice were randomly divided into ASODN group(A group),ASODN combined with DDP group(A+D group),DDP group and physiological saline control group(NS group)(n=8 in each ).Drug treatment was started after randomization.After 1integrin ASODN mediated by cytofectin was directly injected into the xenograft,the volume and weight of the tumor mass were detected,and then the tumor growth inhibitory rate was calculated.Reverse transcription-polymerase chain reaction(RT-PCR) and immunochemohistology assay were used to detect the expression level of 1integrin mRNA.Results:In the A group,the tumor volume and tumor anticancer efficacy were(316.1021.77) mm3 and 48.15%,respectively.The tumor growth inhibitory rate and tumor volume were significantly different between the NS group and the A group(P0.01).In the A+D group,the tumor volume reduced to (178.7040.67)mm3 and the tumor anticancer efficacy was enhanced to 70.37%,which were significantly different compared with those of the DDP group and other controls(P0.05 to P0.01).Significant down-regulation of 1integrin mRNA expression in the tumor tissues of the A group and A+D group was detected by RT-PCR and immunochemohistology assay(P0.01).Conclusions:Singly use of 1integrin ASODN or combined with DDP can effectively inhibit the growth of human ovarian carcinoma xenograft in nude mice by direct intra-tumoral injection.The anticancer efficacy may be associated with the down regulation of 1integrin expression.ASODN targeting 1integrin gene can be a supportive therapy to the ovarian cancer.
2014, 38(4): 438-441.
Abstract:
Objective:To elucidate the relations of the clinical features and liver histological changes of chronic hepatitis B(HBV) patients with alanine aminotransferase(ALT) less than two-time upper limits of normal(ULN).Methods:One hundred and ten cases with chronic HBV infection infection were divided into Ⅰgroup(64 cases) and Ⅱgroup(46 cases) according to the standard of ALT less than or equal to ALT1ULN and 1ULNP0.05).Among all cases,the histologic activity of liver inflammation more than or equal to grade 2 in 21.82%,the fibrosis stage of liver more than or equal to stage 2 in 29.09% and cirrhosis of liver in 19.09%(stage 4) were found.The mean age of patients with HBV DNA more than or equal to 107(copies/ml) was much younger,and their histological grade of liver inflammation and stage of fibrosis were relatively lower.The positive expressions of HBsAg and HBcAg in 81 cases liver tissue were detected by immunohistochemical staining,the differences of immunostaining scores of HBsAg and HBcAg between two groups were not statistical significance(P0.05).Conclusions:The parameters of serological and virological testing in patients with chronic hepatitis B infection couldn't fully reflect the real situation of hepatic lesions.For the older patients with longer periods,liver biopsy should be detected regardless of their ALT levels,particularly for the patients with occult cirrhosis.
Objective:To elucidate the relations of the clinical features and liver histological changes of chronic hepatitis B(HBV) patients with alanine aminotransferase(ALT) less than two-time upper limits of normal(ULN).Methods:One hundred and ten cases with chronic HBV infection infection were divided into Ⅰgroup(64 cases) and Ⅱgroup(46 cases) according to the standard of ALT less than or equal to ALT1ULN and 1ULNP0.05).Among all cases,the histologic activity of liver inflammation more than or equal to grade 2 in 21.82%,the fibrosis stage of liver more than or equal to stage 2 in 29.09% and cirrhosis of liver in 19.09%(stage 4) were found.The mean age of patients with HBV DNA more than or equal to 107(copies/ml) was much younger,and their histological grade of liver inflammation and stage of fibrosis were relatively lower.The positive expressions of HBsAg and HBcAg in 81 cases liver tissue were detected by immunohistochemical staining,the differences of immunostaining scores of HBsAg and HBcAg between two groups were not statistical significance(P0.05).Conclusions:The parameters of serological and virological testing in patients with chronic hepatitis B infection couldn't fully reflect the real situation of hepatic lesions.For the older patients with longer periods,liver biopsy should be detected regardless of their ALT levels,particularly for the patients with occult cirrhosis.
2014, 38(4): 442-444.
Abstract:
Objective:To investigate the expression and pathological features of carbonic anhydrase Ⅸ(CAⅨ)in the ovarian epithelial cancer,and to find out the role of anoxia in the genesis and progression of the disease.Methods:The expression of CAⅨ was determined by immunohistochemical staining in 40 cases of ovarian epithelial cancer,30 cases of carcinoma in situ and 30 cases of normal ovarian tissue.Results:The positive staining rate of CAⅨ in the normal tissue,the carcinoma in situ and ovarian epithelial cancers were 0.0%，16.7% and 52.5%,respectively;The difference was significant(P0.05).In ovarian epithelial cancers,the expression of CAⅨ was significantly associated with the surgical stage,differentiation and lymphatic invasion(P＜0.05).Conclusions:CAⅨ plays an important role in the genesis,invasion and metastasis of the ovarian epithelial cancer;high expression of CAⅨ may be one of the factors for poor prognosis of ovarian epithelial cancers.
Objective:To investigate the expression and pathological features of carbonic anhydrase Ⅸ(CAⅨ)in the ovarian epithelial cancer,and to find out the role of anoxia in the genesis and progression of the disease.Methods:The expression of CAⅨ was determined by immunohistochemical staining in 40 cases of ovarian epithelial cancer,30 cases of carcinoma in situ and 30 cases of normal ovarian tissue.Results:The positive staining rate of CAⅨ in the normal tissue,the carcinoma in situ and ovarian epithelial cancers were 0.0%，16.7% and 52.5%,respectively;The difference was significant(P0.05).In ovarian epithelial cancers,the expression of CAⅨ was significantly associated with the surgical stage,differentiation and lymphatic invasion(P＜0.05).Conclusions:CAⅨ plays an important role in the genesis,invasion and metastasis of the ovarian epithelial cancer;high expression of CAⅨ may be one of the factors for poor prognosis of ovarian epithelial cancers.
2014, 38(4): 445-447,450.
Abstract:
Objective:To investigate the expressions of Ezrin protein and E-cadherin in esophageal squamous cell carcinoma(ESCC) and their correlations with the invasion and metastasis of tumor.Methods:The expressions of Ezrin protein and E-cad in 76 ESCC tissue specimens and 30 normal tissue specimens were detected by SP method.Results:The abnormal expression rates of Ezrin protein and E-cadherin in ESCC tissue and normal tissue were 78.95% 59.21% and 26.67% 6.67%,respectively,the differences of two indicators were statistical significance(P0.01).The differences between the abnormal expression of Ezrin protein and the lymph node metastasis and tissue differentiation degree of esophageal squamous carcinoma were statistical significance(P0.05 and P0.01),the differences between the abnormal expression of E-cadherin and the invasion depth,lymph node metastasis and tissue differentiation degree of esophageal squamous carcinoma were statistical significance(P0.05 to P0.01).There was a positive correlation between the abnormal expression of Ezrin protein and E-cadherin in ESCC(P0.05).The positive expression rate of Ezrin protein in tissue specimens with abnormal E-cadherin expression was significantly higher than that in tissue specimens with normal E-cadherin expression(P0.05).The lymph node metastasis rate in 40 tissue specimens with abnormal E-cadherin and Ezrin protein expressions was 70%,no lymph node metastasis in 11 tissue specimens with normal E-cadherin and Ezrin protein expressions was found,the difference of which was statistical significance(P0.01).Conclusions:The abnormal expressions of Ezrin protein and E-cadherin in ESCC are positively correlated relationship.The combining detection of Ezrin protein and E-cadherin can help to judge the metastasis and prognosis of ESCC.
Objective:To investigate the expressions of Ezrin protein and E-cadherin in esophageal squamous cell carcinoma(ESCC) and their correlations with the invasion and metastasis of tumor.Methods:The expressions of Ezrin protein and E-cad in 76 ESCC tissue specimens and 30 normal tissue specimens were detected by SP method.Results:The abnormal expression rates of Ezrin protein and E-cadherin in ESCC tissue and normal tissue were 78.95% 59.21% and 26.67% 6.67%,respectively,the differences of two indicators were statistical significance(P0.01).The differences between the abnormal expression of Ezrin protein and the lymph node metastasis and tissue differentiation degree of esophageal squamous carcinoma were statistical significance(P0.05 and P0.01),the differences between the abnormal expression of E-cadherin and the invasion depth,lymph node metastasis and tissue differentiation degree of esophageal squamous carcinoma were statistical significance(P0.05 to P0.01).There was a positive correlation between the abnormal expression of Ezrin protein and E-cadherin in ESCC(P0.05).The positive expression rate of Ezrin protein in tissue specimens with abnormal E-cadherin expression was significantly higher than that in tissue specimens with normal E-cadherin expression(P0.05).The lymph node metastasis rate in 40 tissue specimens with abnormal E-cadherin and Ezrin protein expressions was 70%,no lymph node metastasis in 11 tissue specimens with normal E-cadherin and Ezrin protein expressions was found,the difference of which was statistical significance(P0.01).Conclusions:The abnormal expressions of Ezrin protein and E-cadherin in ESCC are positively correlated relationship.The combining detection of Ezrin protein and E-cadherin can help to judge the metastasis and prognosis of ESCC.
2014, 38(4): 448-450.
Abstract:
Objective:To investigate the clinical application value of lauromacrogol and pingyangmycin guided by ultrasound in the treatment of venous malformation.Methods:Fifteen patients with venous malformations were slowly injected with lauromacrogol and pingyangmycin guided by ultrasound.The effects were observed by ultrasound,magnetic resonance imaging and digital subtraction angiography.The patients with poor effects were cured by repeated treatment.All patients were followed up for 6 months to 2 years.Results:All patients were cured by 1 to 5 times treatment.Three patients(20%) appeared skin fester in half of month after operation,and were cured by debridement and suturing.Five patients(33.3%) appeared mild skin pigmentation,embolism and nerve palsy were not found in all patients.Conclusions:Lauromacrogol and pingyangmycin guided by ultrasound for treating venous malformation are good effects,few complication and right means.
Objective:To investigate the clinical application value of lauromacrogol and pingyangmycin guided by ultrasound in the treatment of venous malformation.Methods:Fifteen patients with venous malformations were slowly injected with lauromacrogol and pingyangmycin guided by ultrasound.The effects were observed by ultrasound,magnetic resonance imaging and digital subtraction angiography.The patients with poor effects were cured by repeated treatment.All patients were followed up for 6 months to 2 years.Results:All patients were cured by 1 to 5 times treatment.Three patients(20%) appeared skin fester in half of month after operation,and were cured by debridement and suturing.Five patients(33.3%) appeared mild skin pigmentation,embolism and nerve palsy were not found in all patients.Conclusions:Lauromacrogol and pingyangmycin guided by ultrasound for treating venous malformation are good effects,few complication and right means.
2014, 38(4): 451-454.
Abstract:
Objective:To observe the effect of ezetimibe combined with rosuvastatin in the treatment of patients with hypercholesterolemia.Methods:Seventy-six patients with hypercholesterolemia were randomly divided into two groups：experimental group(n=38，treated with ezetimibe and rosuvastatin) and control group(n=38，treated with rosuvastatin alone，10 mg／d).The lipid levels of all patients were assessed after three months treatment.Results:The cholesterol and low-density lipoprotein levels in experimental group were decreased more remarkably than those in control group(P0.01).In contrary，the alanine aminotransferase and creatine kinase levels in experimental group were increased more remarkably than those in control group(P0.01).The increase of aspartate aminotransferase level in experimental group was lower than that in control group(P0.01).Conclusions:Ezetimibe combined with rosuvastatin can decrease lipid levels than rosuvastatin only when treated patients with hypercholesterolemia,but it need to measure the changes of alanine aminotransferase and creatine kinase levels.
Objective:To observe the effect of ezetimibe combined with rosuvastatin in the treatment of patients with hypercholesterolemia.Methods:Seventy-six patients with hypercholesterolemia were randomly divided into two groups：experimental group(n=38，treated with ezetimibe and rosuvastatin) and control group(n=38，treated with rosuvastatin alone，10 mg／d).The lipid levels of all patients were assessed after three months treatment.Results:The cholesterol and low-density lipoprotein levels in experimental group were decreased more remarkably than those in control group(P0.01).In contrary，the alanine aminotransferase and creatine kinase levels in experimental group were increased more remarkably than those in control group(P0.01).The increase of aspartate aminotransferase level in experimental group was lower than that in control group(P0.01).Conclusions:Ezetimibe combined with rosuvastatin can decrease lipid levels than rosuvastatin only when treated patients with hypercholesterolemia,but it need to measure the changes of alanine aminotransferase and creatine kinase levels.
2014, 38(4): 453-455.
Abstract:
Objective:To investigate the expression of carbonic anhydrase Ⅸ(CAⅨ) in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters.Methods:The expression of CAⅨ in 30 cases of normal esophageal tissues and 76 cases of esophageal squamous cell carcinoma tissues were detected by immunohistochemical staining,the relationships between CAⅨ expression and esophageal squamous cell carcinoma was evaluated.Results:The expression rate of CAⅨ in normal esophageal tissues(6.67%) was significantly lower than that in esophageal squamous cell carcinoma(72.06%)(P0.01).The expression of CAⅨ was significantly associated with the clinical stage,cell differentiation degree and lymph node metastasis of esophageal squamous cell carcinoma(P0.05).Conclusions:The high expression of CAⅨ is an important index in the estimation of esophageal squamous cell carcinoma prognosis.
Objective:To investigate the expression of carbonic anhydrase Ⅸ(CAⅨ) in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters.Methods:The expression of CAⅨ in 30 cases of normal esophageal tissues and 76 cases of esophageal squamous cell carcinoma tissues were detected by immunohistochemical staining,the relationships between CAⅨ expression and esophageal squamous cell carcinoma was evaluated.Results:The expression rate of CAⅨ in normal esophageal tissues(6.67%) was significantly lower than that in esophageal squamous cell carcinoma(72.06%)(P0.01).The expression of CAⅨ was significantly associated with the clinical stage,cell differentiation degree and lymph node metastasis of esophageal squamous cell carcinoma(P0.05).Conclusions:The high expression of CAⅨ is an important index in the estimation of esophageal squamous cell carcinoma prognosis.
2014, 38(4): 456-458.
Abstract:
Objective:To explore the effects of tubal pregnancy treated with different conservative methods on the patient's fecundity and reproductive function.Methods:Two hundred and thirty-eight ectopic pregnancy patients with fertility requirement were divided into laparoscopic surgery group(109 cases),laparotomy group(54 cases) and drug treatment group(75 cases) according to the treatment method.The rates of tubal patency,intrauterine pregnancy and recurrent tubal pregnancy in three groups were compared.Results:After laparoscopic treatment, tubal patency rate and the intrauterine pregnancy rate is higher than laparotomy group and drug group(P0.05). All three groups had no statistically significant difference in the rate of recurrent tubal pregnancy (P0.05).Conclusions:Comprehensive treatment of laparoscopic tubal pregnancy suitable for patients with fertility requirements.
Objective:To explore the effects of tubal pregnancy treated with different conservative methods on the patient's fecundity and reproductive function.Methods:Two hundred and thirty-eight ectopic pregnancy patients with fertility requirement were divided into laparoscopic surgery group(109 cases),laparotomy group(54 cases) and drug treatment group(75 cases) according to the treatment method.The rates of tubal patency,intrauterine pregnancy and recurrent tubal pregnancy in three groups were compared.Results:After laparoscopic treatment, tubal patency rate and the intrauterine pregnancy rate is higher than laparotomy group and drug group(P0.05). All three groups had no statistically significant difference in the rate of recurrent tubal pregnancy (P0.05).Conclusions:Comprehensive treatment of laparoscopic tubal pregnancy suitable for patients with fertility requirements.
2014, 38(4): 459-461,465.
Abstract:
Objective:To investigate the clinical effect of limited fluid infusion in treatment of cirrhosis patients with massive upper gastrointestinal hemorrhage.Methods:One hundred and nine cirrhosis patients with massive upper gastrointestinal hemorrhage were randomly divided into limited fluid infusion group(53 cases) and limited fluid infusion group(56 cases),and each group was given limited fluid infusion or common fluid infusion as well as therapies for restraining the gastric acid,hematischesis and lowering the portal venous pressure.The hematischesis time,complication and mortality rate were compared between the two groups.Results:The average hemostasis time of limited fluid infusion group was obviously less than that of the control group(P0.01).In limited fluid infusion group,only 2 patients presented mild hepatic encephalopathy and no one died;however,in the control group,3 patients had hepatic encephalopathy,13 were complicated with ascites,4 presented oliguria or anuria,1 was complicated with spontaneous peritonitis and 14 died.The complication and fatality rates had statistical difference between the two groups(P0.01).Conclusions:Limited fluid infusion is advantageous for cirrhosis patients combined with massive upper gastrointestinal hemorrhage.It may reduce the incidence of ascites,hepatic encephalopathy and hepatorenal syndrome,eventually decreasing the fatality rate.
Objective:To investigate the clinical effect of limited fluid infusion in treatment of cirrhosis patients with massive upper gastrointestinal hemorrhage.Methods:One hundred and nine cirrhosis patients with massive upper gastrointestinal hemorrhage were randomly divided into limited fluid infusion group(53 cases) and limited fluid infusion group(56 cases),and each group was given limited fluid infusion or common fluid infusion as well as therapies for restraining the gastric acid,hematischesis and lowering the portal venous pressure.The hematischesis time,complication and mortality rate were compared between the two groups.Results:The average hemostasis time of limited fluid infusion group was obviously less than that of the control group(P0.01).In limited fluid infusion group,only 2 patients presented mild hepatic encephalopathy and no one died;however,in the control group,3 patients had hepatic encephalopathy,13 were complicated with ascites,4 presented oliguria or anuria,1 was complicated with spontaneous peritonitis and 14 died.The complication and fatality rates had statistical difference between the two groups(P0.01).Conclusions:Limited fluid infusion is advantageous for cirrhosis patients combined with massive upper gastrointestinal hemorrhage.It may reduce the incidence of ascites,hepatic encephalopathy and hepatorenal syndrome,eventually decreasing the fatality rate.
2014, 38(4): 462-465.
Abstract:
Objective:To explore the association of MRI features of invasive and noninvasive pituitary adenomas with the expressions of galectin-3(Gal-3) and matrixmetalloproteinase-2(MMP-2).Methods:MRI was performed preoperatively on 43 patients with histologically verified pituitary adenomas;immunohistochemistry was applied to detect the protein expressions of Gal-3 and MMP-2 in the invasive and non-invasive pituitary adenomas tissues.The MRI features and their correlation with the expressions of Gal-3 and MMP-2 were analyzed.Results:The expressions of Gal-3 and MMP-2 in the invasive pituitary adenomas were significantly higher than those in the non-invasive pituitary adenomas(P0.01).The Gal-3 and MMP-2 was positively correlated in invasive pituitary adenomas(P0.01).Conclusions:The expressions of Gal-3 and MMP-2 are closely associated with the aggressiveness of the pituitary adenoma,which may act as potential molecular markers for assessment of the invasive potential of pituitary adenomas.The cleavage of Gal-3 might be responsible for the tumorigenic potential of the cells and provide useful targets for molecular therapeutic strategy against invasive pituitary adenomas.
Objective:To explore the association of MRI features of invasive and noninvasive pituitary adenomas with the expressions of galectin-3(Gal-3) and matrixmetalloproteinase-2(MMP-2).Methods:MRI was performed preoperatively on 43 patients with histologically verified pituitary adenomas;immunohistochemistry was applied to detect the protein expressions of Gal-3 and MMP-2 in the invasive and non-invasive pituitary adenomas tissues.The MRI features and their correlation with the expressions of Gal-3 and MMP-2 were analyzed.Results:The expressions of Gal-3 and MMP-2 in the invasive pituitary adenomas were significantly higher than those in the non-invasive pituitary adenomas(P0.01).The Gal-3 and MMP-2 was positively correlated in invasive pituitary adenomas(P0.01).Conclusions:The expressions of Gal-3 and MMP-2 are closely associated with the aggressiveness of the pituitary adenoma,which may act as potential molecular markers for assessment of the invasive potential of pituitary adenomas.The cleavage of Gal-3 might be responsible for the tumorigenic potential of the cells and provide useful targets for molecular therapeutic strategy against invasive pituitary adenomas.
2014, 38(4): 466-468.
Abstract:
Objective:To explore the effect of tamsulosin combined with solifenacin for the treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy(ESWL).Methods:Two hundred and seventy patients with distal ureteral calculi were evenly divided into three groups.After ESWL,group A were administered tamsulosin 0.2 mg,group B solifenacin 5 mg and group C solifenacin 5 mg plus tamsulosin 0.2 mg once a day.The expulsion rate and expulsion time of the stone,the recurrence of renal colic,the steinstrasse formation and the side effects during the therapy were compared among the three groups.Results:For the lithiasis 6-10 mm in diameter,there was no significant difference in the stone expulsion rate(P0.05);for the lithiasis 10 mm in diameter,the stone expulsion rate of group C(100.0%) was significantly higher than that of group A(90.5%) and group B(84.8%)(P0.05);the expulsion time of the stone in group C was shorter than group A and B(P0.01),but the pain degree during the stone expulsion in group C was lower than group B(P0.05).The recurrence rate of renal colic and the steinstrasse formation rate had no significant differences among the three groups(P0.05).No severe side effects were observed among the three groups(P0.05).Conclusions:Combination use of tamsulosin and solifenacin is safe and effective for treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy.It may shorten the stone expulsion time and reduce the steinstrasse formation rate,and is especially suitable for the lithiasis10 mm in diameter.
Objective:To explore the effect of tamsulosin combined with solifenacin for the treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy(ESWL).Methods:Two hundred and seventy patients with distal ureteral calculi were evenly divided into three groups.After ESWL,group A were administered tamsulosin 0.2 mg,group B solifenacin 5 mg and group C solifenacin 5 mg plus tamsulosin 0.2 mg once a day.The expulsion rate and expulsion time of the stone,the recurrence of renal colic,the steinstrasse formation and the side effects during the therapy were compared among the three groups.Results:For the lithiasis 6-10 mm in diameter,there was no significant difference in the stone expulsion rate(P0.05);for the lithiasis 10 mm in diameter,the stone expulsion rate of group C(100.0%) was significantly higher than that of group A(90.5%) and group B(84.8%)(P0.05);the expulsion time of the stone in group C was shorter than group A and B(P0.01),but the pain degree during the stone expulsion in group C was lower than group B(P0.05).The recurrence rate of renal colic and the steinstrasse formation rate had no significant differences among the three groups(P0.05).No severe side effects were observed among the three groups(P0.05).Conclusions:Combination use of tamsulosin and solifenacin is safe and effective for treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy.It may shorten the stone expulsion time and reduce the steinstrasse formation rate,and is especially suitable for the lithiasis10 mm in diameter.
2014, 38(4): 469-471.
Abstract:
Objective:To observe the effect of nickel TiNi shape memory alloy patellar concentrator in treating patella fractures.Methods:The clinical data of 90 cases of patellar fracture treated by using the nickel TiNi patellar concentrator were analyzed retrospectively.Results:According to the luks evaluation standards,the effect was excellent in 82 cases,good in 6 cases and fair in 2 cases.Conclusions:The nickel TiNi patellar concentrator is an ideal procedure for patellar fracture.
Objective:To observe the effect of nickel TiNi shape memory alloy patellar concentrator in treating patella fractures.Methods:The clinical data of 90 cases of patellar fracture treated by using the nickel TiNi patellar concentrator were analyzed retrospectively.Results:According to the luks evaluation standards,the effect was excellent in 82 cases,good in 6 cases and fair in 2 cases.Conclusions:The nickel TiNi patellar concentrator is an ideal procedure for patellar fracture.
2014, 38(4): 471-473.
Abstract:
Objective:To observe the efficacy and safety of capecitabine combined with oxaliplatin and docetaxel(DOX regimen)in treatment of advanced gastric cancer.Methods:A total of 26 patients with advanced gastric cancer confirmed by pathology were included in this study.All the patients were given oral administration of capecitabine 2 000 mg/m2 two times a day;on d1-14,oxaliplatin 130 mg/m2 and docetaxel 60 mg/m2 were given intravenously for more than 2 hours each time.The regimen was repeated every 21 days.Results:Complete response was observed in 2 cases,partial response in 12,stable in 8 and progression in 4.The total effective rate was 53.8%;the median time to progression was 6 months and the median overall survival was 11 months.The main side effects were bone marrow suppression,nausea,vomiting,neurotoxicity and diarrhea.Conclusions:DOX is an effective,safe and well tolerated chemotherapy regimen for patients with advanced gastric cancer.It is worthy of clinical popularization.
Objective:To observe the efficacy and safety of capecitabine combined with oxaliplatin and docetaxel(DOX regimen)in treatment of advanced gastric cancer.Methods:A total of 26 patients with advanced gastric cancer confirmed by pathology were included in this study.All the patients were given oral administration of capecitabine 2 000 mg/m2 two times a day;on d1-14,oxaliplatin 130 mg/m2 and docetaxel 60 mg/m2 were given intravenously for more than 2 hours each time.The regimen was repeated every 21 days.Results:Complete response was observed in 2 cases,partial response in 12,stable in 8 and progression in 4.The total effective rate was 53.8%;the median time to progression was 6 months and the median overall survival was 11 months.The main side effects were bone marrow suppression,nausea,vomiting,neurotoxicity and diarrhea.Conclusions:DOX is an effective,safe and well tolerated chemotherapy regimen for patients with advanced gastric cancer.It is worthy of clinical popularization.
2014, 38(4): 474-475,478.
Abstract:
Objective:To study the clinical efficacy of dialectical acupoints selection therapy on functional dyspepsia associated with sleep disorders.Methods:Eighty patients receiving dialectical acupoints selection acupuncture for functional dyspepsia with sleep disorders were included in this study.The intensity and attack frequency of functional dyspepsia were evaluated after the treatment;Pittsburgh Sleep Quality Index was employed to compare the results before and after the therapy.Results:The outcome was good in 91.3% of the patients and only 7 cases(8.7%) complained of obvious abdominal pain and other symptoms;after treatment,the sleep quality,sleep efficiency,daytime dysfunction,falling-asleep time,sleep time and sleep disorders of the patients improved in different degree(P 0.01).Conclusions:Dialectical acupoints selection therapy has a good therapeutic effect on functional dyspepsia associated with sleep disorders.
Objective:To study the clinical efficacy of dialectical acupoints selection therapy on functional dyspepsia associated with sleep disorders.Methods:Eighty patients receiving dialectical acupoints selection acupuncture for functional dyspepsia with sleep disorders were included in this study.The intensity and attack frequency of functional dyspepsia were evaluated after the treatment;Pittsburgh Sleep Quality Index was employed to compare the results before and after the therapy.Results:The outcome was good in 91.3% of the patients and only 7 cases(8.7%) complained of obvious abdominal pain and other symptoms;after treatment,the sleep quality,sleep efficiency,daytime dysfunction,falling-asleep time,sleep time and sleep disorders of the patients improved in different degree(P 0.01).Conclusions:Dialectical acupoints selection therapy has a good therapeutic effect on functional dyspepsia associated with sleep disorders.
2014, 38(4): 476-478.
Abstract:
Objective:To explore the prophylactic effect of penehyelidine combined with tropisetron in prevention of nausea and vomiting after laparoscopic cholecystectomy.Methods:Sixty patients having received laparoscopic cholecystectomy were randomly divided into three groups:tropisetron combined with dexamethasone group(group A),tropisetron group(group B) and physiological saline group(group C),with 20 cases in each.The incidence of postoperative nausea and vomiting was observed within 24 hours after the operation.Results:The visual analogus scales(VAS) score of nausea at T1-T4 in group C was significantly higher than that in group A and group B(P0.01);the VAS score at T1 and T2 in group A was significantly lower than that in group B(P0.01);and there was no significant difference between the two groups in the VAS score at T3 and T4(P＞0.05).The incidence of vomiting after awakening from 0 to 6,0 to 12 and 0 to 24 hours in group A and group B was significantly lower than that in group C(P0.01);and the incidences of vomiting in group A and B had no statistically significant difference(P＞0.05).Conclusions:The application of penehydidine combined with tropisetron can obviously reduce the incidence of nausea and vomiting after laparoscopic cholecystectomy,and is more effective than using tropisetron alone.It is worth popularizing in clinical application.
Objective:To explore the prophylactic effect of penehyelidine combined with tropisetron in prevention of nausea and vomiting after laparoscopic cholecystectomy.Methods:Sixty patients having received laparoscopic cholecystectomy were randomly divided into three groups:tropisetron combined with dexamethasone group(group A),tropisetron group(group B) and physiological saline group(group C),with 20 cases in each.The incidence of postoperative nausea and vomiting was observed within 24 hours after the operation.Results:The visual analogus scales(VAS) score of nausea at T1-T4 in group C was significantly higher than that in group A and group B(P0.01);the VAS score at T1 and T2 in group A was significantly lower than that in group B(P0.01);and there was no significant difference between the two groups in the VAS score at T3 and T4(P＞0.05).The incidence of vomiting after awakening from 0 to 6,0 to 12 and 0 to 24 hours in group A and group B was significantly lower than that in group C(P0.01);and the incidences of vomiting in group A and B had no statistically significant difference(P＞0.05).Conclusions:The application of penehydidine combined with tropisetron can obviously reduce the incidence of nausea and vomiting after laparoscopic cholecystectomy,and is more effective than using tropisetron alone.It is worth popularizing in clinical application.
2014, 38(4): 479-481.
Abstract:
Objective:To observe the effects of muscle strength training on patellar strain.Methods:Forty students with different agree patellar strain from physical education department were randomly divided into rehabilitation group and control group.The rehabilitation group and control group taken exercise by quadriceps isometric exercise and standing on the peg,respectively,the effects of two groups were compared.Results:The total effective rates of two groups were 85.0% and 65.0%,respectively,the differece of which had no statistical significance(P0.05).The difference of the total scores of clinical symptoms in two groups had no statistical significance(P0.05).The differences of the knee pain scores and quadriceps peak torque increasing in two groups had statistical significance(P0.01).Conclusions:Muscle strength training can significantly strengthen quadriceps strength and alleviate the symptoms of patients with patellar strain.
Objective:To observe the effects of muscle strength training on patellar strain.Methods:Forty students with different agree patellar strain from physical education department were randomly divided into rehabilitation group and control group.The rehabilitation group and control group taken exercise by quadriceps isometric exercise and standing on the peg,respectively,the effects of two groups were compared.Results:The total effective rates of two groups were 85.0% and 65.0%,respectively,the differece of which had no statistical significance(P0.05).The difference of the total scores of clinical symptoms in two groups had no statistical significance(P0.05).The differences of the knee pain scores and quadriceps peak torque increasing in two groups had statistical significance(P0.01).Conclusions:Muscle strength training can significantly strengthen quadriceps strength and alleviate the symptoms of patients with patellar strain.
2014, 38(4): 482-483,486.
Abstract:
Objective:To evaluate the efficacy and safety of recombinant human granulocyte colony-stimulating factor(rhG-CSF) in the treatment of leucopenia after chemotherapy.Methods:Sixty-two patients with leucopenia after chemotherapy were randomly divided into observation group and control group(31 cases each group).The 150 g of rhG-CSF were subcutaneously injected into the observation group once a day.The control group were treated with Weidakang particles two bags per time three times a day for one week,then one bag per time three times a day by oral.The drug was stopped when the level of leukocyte arrived at normal.Results:The treatment with rhG-CSF or Weidakang particles were able to make the level of leukocyte after chemotherapy recover normal range,the recovery time in observation group was less than that in control group(P0.05 to P0.01).Conclusions:The rhG-CSF for treating leucopenia caused by malignant tumor after chemotherapy is good,which is worthy of clinical application.
Objective:To evaluate the efficacy and safety of recombinant human granulocyte colony-stimulating factor(rhG-CSF) in the treatment of leucopenia after chemotherapy.Methods:Sixty-two patients with leucopenia after chemotherapy were randomly divided into observation group and control group(31 cases each group).The 150 g of rhG-CSF were subcutaneously injected into the observation group once a day.The control group were treated with Weidakang particles two bags per time three times a day for one week,then one bag per time three times a day by oral.The drug was stopped when the level of leukocyte arrived at normal.Results:The treatment with rhG-CSF or Weidakang particles were able to make the level of leukocyte after chemotherapy recover normal range,the recovery time in observation group was less than that in control group(P0.05 to P0.01).Conclusions:The rhG-CSF for treating leucopenia caused by malignant tumor after chemotherapy is good,which is worthy of clinical application.
2014, 38(4): 484-486.
Abstract:
Objective:To explore the causes of cervical lymphadenectasis for guiding clinical diagnosis and treatment.Methods:The biopsy of 180 patients with cervical lymphadenectasis for starting symptom were invetigated from Jan.2008 to Apr.2013,these pathological data were retrospectively analyzed.Results:Ninty-six cases of 180 patients were malignant lymphadenectasis(53.33%),mainly for metastatic carcinoma 39 cases(40.62%)and non-Hodgkin's lymphoma 40 cases(41.67%),the causes of 8 cases with lymph node metastasis carcinoma were unknown(20.51%).Eighty-four cases of 180 patients were benign lymph node enlargement(46.67%),mainly for non-specific lymphadenitis(38.09%)and lymph node tuberculosis(40.48%).Conclusions:The metastatic carcinoma and non-Hodgkin's lymphoma are more common in cervical lymphadenectasis,non-specific lymphadenitis and lymph node tuberculosis are common in benign lymph node enlargement.The lymph node biopsy in patients with cervical lymphadenectasis of unknown causes should be implemented for making a definitive diagnosis in time.
Objective:To explore the causes of cervical lymphadenectasis for guiding clinical diagnosis and treatment.Methods:The biopsy of 180 patients with cervical lymphadenectasis for starting symptom were invetigated from Jan.2008 to Apr.2013,these pathological data were retrospectively analyzed.Results:Ninty-six cases of 180 patients were malignant lymphadenectasis(53.33%),mainly for metastatic carcinoma 39 cases(40.62%)and non-Hodgkin's lymphoma 40 cases(41.67%),the causes of 8 cases with lymph node metastasis carcinoma were unknown(20.51%).Eighty-four cases of 180 patients were benign lymph node enlargement(46.67%),mainly for non-specific lymphadenitis(38.09%)and lymph node tuberculosis(40.48%).Conclusions:The metastatic carcinoma and non-Hodgkin's lymphoma are more common in cervical lymphadenectasis,non-specific lymphadenitis and lymph node tuberculosis are common in benign lymph node enlargement.The lymph node biopsy in patients with cervical lymphadenectasis of unknown causes should be implemented for making a definitive diagnosis in time.
2014, 38(4): 487-489.
Abstract:
Objective:To investigate the relationship between the blood platelet count(BPC) and liver function after splenectomy and disconnection in patient with portal hypertension.Methods:The clinical data of 106 patients treated with splenectomy and disconnection were retrospectively analyzed，the BPC of patient with grade A，B and C liver function were compared before and after operation.Results:The BPC in patients with grade A liver function were higher than that in patients with grade B and C liver function in 2 weeks after operation(P0.05 and P0.01).The BPC in patients with the improvement of liver function after operation were significantly higher than that before operation(P0.01).The differences of BPC in patients with the deterioration of liver function before and after operation had nostatistical significance(P0.05).The difference of BPC before and after operation in patients with the improvement of liver function was significantly higher than that in patients with the deterioration of liver function(P0.01).Conclusions:The decreasing BPC in patient with portal hypertension is related to hypersplenism and liver function.
Objective:To investigate the relationship between the blood platelet count(BPC) and liver function after splenectomy and disconnection in patient with portal hypertension.Methods:The clinical data of 106 patients treated with splenectomy and disconnection were retrospectively analyzed，the BPC of patient with grade A，B and C liver function were compared before and after operation.Results:The BPC in patients with grade A liver function were higher than that in patients with grade B and C liver function in 2 weeks after operation(P0.05 and P0.01).The BPC in patients with the improvement of liver function after operation were significantly higher than that before operation(P0.01).The differences of BPC in patients with the deterioration of liver function before and after operation had nostatistical significance(P0.05).The difference of BPC before and after operation in patients with the improvement of liver function was significantly higher than that in patients with the deterioration of liver function(P0.01).Conclusions:The decreasing BPC in patient with portal hypertension is related to hypersplenism and liver function.
2014, 38(4): 489-491.
Abstract:
Objective:To discuss the diagnostic criteria of neurosyphilis and decrease the misdiagnosis and missed diagnosis of the disease.Methods:The clinical data of 13 cases of neurosyphilis were presented,and the clinical manifestation,typing and diagnostic criteria of the disease were analyzed by review of the literature.Results:Among the 13 cases of neurosyphilis,3 cases had asymptomatic neurosyphilis,5 meningovascular syphilis，2 tabes dorsalis and 3 paralytic dementia;4 of the cases were misdiagnosed.The common symptoms included mental and behavioral abnormalities,epileptic seizure and multiple cerebral infarctions.The imageology manifestation showed brain atrophy,hydrocephalus,multiple cerebral infarction and middle cerebral artery stenosis or occlusion.Conclusions:The clinical manifestations of neurosyphilis are varied and lack of specificity;it is easy to be misdiagnosed or misdiagnosed.Abnormal imageology would be of help to the diagnosis of the disease.
Objective:To discuss the diagnostic criteria of neurosyphilis and decrease the misdiagnosis and missed diagnosis of the disease.Methods:The clinical data of 13 cases of neurosyphilis were presented,and the clinical manifestation,typing and diagnostic criteria of the disease were analyzed by review of the literature.Results:Among the 13 cases of neurosyphilis,3 cases had asymptomatic neurosyphilis,5 meningovascular syphilis，2 tabes dorsalis and 3 paralytic dementia;4 of the cases were misdiagnosed.The common symptoms included mental and behavioral abnormalities,epileptic seizure and multiple cerebral infarctions.The imageology manifestation showed brain atrophy,hydrocephalus,multiple cerebral infarction and middle cerebral artery stenosis or occlusion.Conclusions:The clinical manifestations of neurosyphilis are varied and lack of specificity;it is easy to be misdiagnosed or misdiagnosed.Abnormal imageology would be of help to the diagnosis of the disease.
2014, 38(4): 492-493.
Abstract:
Objective:To investigate the sex hormone levels of infertile males with oligospermia or azoospermia and its clinical significance.Methods:The semen of 57 cases with oligospermia(oligospermia group)，21 cases with azoospermia(azoospermia group) and 30 cases with rormal sperm count(control group) were analysed.The serum levels of testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(P) of all cases were determined by chemiluminescent immunoassay.Results:The levels of FSH and LH in the azoospermia and oligospermia group were higher than that in control group(P0.05-P0.01).The FSH and LH levels of the azoospermia group were significantly higher than that in oligospermia group(P0.01).The level of PRL in azoospermia group was higher than those in the control and oligospermia group(P0.01).The T levels of the azoospermia and oligospermia group were significantly lower than that in control group(P0.01).Conclusions:The serum levels of sex hormone of infertile males with oligospermia or azoospermia can help guide diagnosis and treatment and prognosis.
Objective:To investigate the sex hormone levels of infertile males with oligospermia or azoospermia and its clinical significance.Methods:The semen of 57 cases with oligospermia(oligospermia group)，21 cases with azoospermia(azoospermia group) and 30 cases with rormal sperm count(control group) were analysed.The serum levels of testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(P) of all cases were determined by chemiluminescent immunoassay.Results:The levels of FSH and LH in the azoospermia and oligospermia group were higher than that in control group(P0.05-P0.01).The FSH and LH levels of the azoospermia group were significantly higher than that in oligospermia group(P0.01).The level of PRL in azoospermia group was higher than those in the control and oligospermia group(P0.01).The T levels of the azoospermia and oligospermia group were significantly lower than that in control group(P0.01).Conclusions:The serum levels of sex hormone of infertile males with oligospermia or azoospermia can help guide diagnosis and treatment and prognosis.
2014, 38(4): 494-496.
Abstract:
Objective:To explore the individual design and operation skill in repairing iris injury.Methods:Fifteen eyes in 13 patients were treated with sclera clamping method,double curved needle polypropylene suture method,needle probe method,modified McCannal style and Siepser style to suture iris according to the iridodialysis range,respectively.The pupil shape,vision,intraocular pressure,corneal endothelial cell change,monocular diplopia,sensitivity to light and glare in 13 cases were investigated during the period of following up for 3 months.Results:The naked eye eyesight of 11 eyes and 4 eyes were more than or equal to 0.5 and 0.1-0.4 in 3 months after operation,respectively.The pupils of patients were round or oval,their intraocular pressure was normal.Except Siepser style to suture iris,the corneal endothelial cell loss rate in other four kinds of surgical methods were 5.16% to 26.57%,the difference of which had statistical significance(P0.05),there were not monocular diplopia,sensitivity to light and glare in patients.Conclusions:The individual prosthetics in repairing iris injury can improve eyesight,eliminate the symptoms of monocular diplopia,photophobia and glare and visual quality,which can achieve the purpose of minimum damage and maximum visual function recovery.
Objective:To explore the individual design and operation skill in repairing iris injury.Methods:Fifteen eyes in 13 patients were treated with sclera clamping method,double curved needle polypropylene suture method,needle probe method,modified McCannal style and Siepser style to suture iris according to the iridodialysis range,respectively.The pupil shape,vision,intraocular pressure,corneal endothelial cell change,monocular diplopia,sensitivity to light and glare in 13 cases were investigated during the period of following up for 3 months.Results:The naked eye eyesight of 11 eyes and 4 eyes were more than or equal to 0.5 and 0.1-0.4 in 3 months after operation,respectively.The pupils of patients were round or oval,their intraocular pressure was normal.Except Siepser style to suture iris,the corneal endothelial cell loss rate in other four kinds of surgical methods were 5.16% to 26.57%,the difference of which had statistical significance(P0.05),there were not monocular diplopia,sensitivity to light and glare in patients.Conclusions:The individual prosthetics in repairing iris injury can improve eyesight,eliminate the symptoms of monocular diplopia,photophobia and glare and visual quality,which can achieve the purpose of minimum damage and maximum visual function recovery.
2014, 38(4): 497-499.
Abstract:
Objective:To explore the clinical significance of heart rate variability in functional ventricular premature beat children of different ages.Methods:A total of 102 children with functional ventricular premature beat was randomly divided into three groups according to their ages:infant group，preschool group and school-age group.The HRV time domain value was measured in all the children with 24 dynamic electrocardiograms and the results were analyzed.Results:The percentage of differences exceeding 50 ms in the adjacent normal number of intervals,standard deviation of nn intervals，rMSSD,SDANN and SDSD were significantly higher in the preschool children group and school-age group than those in the infant group(P0.01).The PNN50,rMSSD and SDSD were significantly different between the preschool children group and the school-age group(P0.05).Conclusions:The autonomic nervous system of children will develop with the age;ventricular premature beat is closely related with the autonomic nervous function status and imbalances.
Objective:To explore the clinical significance of heart rate variability in functional ventricular premature beat children of different ages.Methods:A total of 102 children with functional ventricular premature beat was randomly divided into three groups according to their ages:infant group，preschool group and school-age group.The HRV time domain value was measured in all the children with 24 dynamic electrocardiograms and the results were analyzed.Results:The percentage of differences exceeding 50 ms in the adjacent normal number of intervals,standard deviation of nn intervals，rMSSD,SDANN and SDSD were significantly higher in the preschool children group and school-age group than those in the infant group(P0.01).The PNN50,rMSSD and SDSD were significantly different between the preschool children group and the school-age group(P0.05).Conclusions:The autonomic nervous system of children will develop with the age;ventricular premature beat is closely related with the autonomic nervous function status and imbalances.
Standard large trauma craniotomy for treatment of severe traumatic brain injury:a report of 32 cases
2014, 38(4): 499-502.
Abstract:
Objective:To compare the clinical efficacy of standard large trauma craniotomy and routine temporoparietal craniectomy in treatment of severe traumatic brain injuries.Methods:Sixty-two patients with severe traumatic brain injuries were randomly divided into treatment group(n=32) and control group(n=30).The control group underwent routine craniectomy and decompressive craniectomy together with dura opening with the bone window size of 6 cm8 cm.The treatment group received large trauma craniotomy and bone disc decompression craniotomy with the bone window size of 12 cm15 cm.Epidural relaxation suture repair was performed simultaneously during the operation.The postoperative intracranial pressure,complication rate and prognosis of the two groups were compared.Results:Half a month after the operation,the incidence of 3 d continuous intracranial pressure of the treatment group was 12.5%,which was lower than that of the control group(33.3%)(P0.05).There was no significant difference in traumatic cerebral infarction,complication of brain tissue incision hernia,traumatic epilepsy and traumatic hydrocephalus between the two groups(P0.05).The recovery rate of moderate disability was 84.4% in the treatment group and 60.0% in the control group.The prognosis of the treatment group was better than that of the control group(P0.05).Conclusions:Standard large trauma craniotomy can significantly reduce the brain damage,preserve the brain function and decrease the incidences of complications.It is more effective than the routine temporoparietal craniectomy for treatment of severe traumatic brain injuries.
Objective:To compare the clinical efficacy of standard large trauma craniotomy and routine temporoparietal craniectomy in treatment of severe traumatic brain injuries.Methods:Sixty-two patients with severe traumatic brain injuries were randomly divided into treatment group(n=32) and control group(n=30).The control group underwent routine craniectomy and decompressive craniectomy together with dura opening with the bone window size of 6 cm8 cm.The treatment group received large trauma craniotomy and bone disc decompression craniotomy with the bone window size of 12 cm15 cm.Epidural relaxation suture repair was performed simultaneously during the operation.The postoperative intracranial pressure,complication rate and prognosis of the two groups were compared.Results:Half a month after the operation,the incidence of 3 d continuous intracranial pressure of the treatment group was 12.5%,which was lower than that of the control group(33.3%)(P0.05).There was no significant difference in traumatic cerebral infarction,complication of brain tissue incision hernia,traumatic epilepsy and traumatic hydrocephalus between the two groups(P0.05).The recovery rate of moderate disability was 84.4% in the treatment group and 60.0% in the control group.The prognosis of the treatment group was better than that of the control group(P0.05).Conclusions:Standard large trauma craniotomy can significantly reduce the brain damage,preserve the brain function and decrease the incidences of complications.It is more effective than the routine temporoparietal craniectomy for treatment of severe traumatic brain injuries.
2014, 38(4): 513-515.
Abstract:
Objective:To investigate the editors mental health of Anhui province's university journal.Methods:Ninety-two journal editors selected by convenient sampling from 50 universities in Anhui province were investigated using the Symptom Checklist 90(SCL-90) questionnaire.Results:The total score of SCL-90 was 132.7125.90,the scores of somatization,obsessive-compulsive symptoms,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation and psychotic factor were 1.470.38,1.710.48,1.510.42,1.500.38,1.430.36,1.420.37,1.220.27,1.490.39 and 1.400.27,respectively.The total scores of SCL-90 in 16 cases were more than or equal to 160.The detection rate of obsessive-compulsive symptoms was the highest,which accounted for 30.4%.The differences of the total score of SCL-90 between editors and national adult norm were not statistically significant(P0.05).The scores of somatization and psychotic factor of editors were higher than that of national adult norm(P0.05),but their interpersonal sensitivity score was lower(P0.05).There were not statistical signifinances between the scores of obsessive compssive sympoms,depression,anxiety,hostility,phobic anxiety and paranoid in two groups(P0.05).Conclusions:The overall level of mental health between editors and national adult norm are similar.Compared with national adult norm,the scores of somatization and psychiatric factors of editors are high,and their interpersonal sensitivity factors scores are low.
Objective:To investigate the editors mental health of Anhui province's university journal.Methods:Ninety-two journal editors selected by convenient sampling from 50 universities in Anhui province were investigated using the Symptom Checklist 90(SCL-90) questionnaire.Results:The total score of SCL-90 was 132.7125.90,the scores of somatization,obsessive-compulsive symptoms,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation and psychotic factor were 1.470.38,1.710.48,1.510.42,1.500.38,1.430.36,1.420.37,1.220.27,1.490.39 and 1.400.27,respectively.The total scores of SCL-90 in 16 cases were more than or equal to 160.The detection rate of obsessive-compulsive symptoms was the highest,which accounted for 30.4%.The differences of the total score of SCL-90 between editors and national adult norm were not statistically significant(P0.05).The scores of somatization and psychotic factor of editors were higher than that of national adult norm(P0.05),but their interpersonal sensitivity score was lower(P0.05).There were not statistical signifinances between the scores of obsessive compssive sympoms,depression,anxiety,hostility,phobic anxiety and paranoid in two groups(P0.05).Conclusions:The overall level of mental health between editors and national adult norm are similar.Compared with national adult norm,the scores of somatization and psychiatric factors of editors are high,and their interpersonal sensitivity factors scores are low.
2014, 38(4): 516-518.
Abstract:
Objective:To study the self-worth(SW) status of nursing students in higher vocational schools.Methods:One thousand eight hundred and eighteen students were surveyed by stratified cluster sampling,using Self-worth Scale for Adolescents.Results:The nursing students from higher vocational schools have recorded higher scores than the national norms in terms of total,regular and special dimensions of SW(P＜0.01);the personal-oriented interpersonal SW amid second-year students and the society-oriented moral SW amid interns are significantly lower than the national norms(P＜0.01);the interns' interpersonal SW does not vary statistically(P＞0.05).The abnormal rate of interpersonal dimension of the interns is higher than that of the first-year and second-year students,while the difference is not significant between the first-year and second-year students(P＞0.05).Conclusions:The nursing students from higher vocational schools have recorded higher scores than the national norms in most SW;with the involvement of professional factors,some profession-associated dimensions present abnormal,which may be related to the professional demand for the nursing students.
Objective:To study the self-worth(SW) status of nursing students in higher vocational schools.Methods:One thousand eight hundred and eighteen students were surveyed by stratified cluster sampling,using Self-worth Scale for Adolescents.Results:The nursing students from higher vocational schools have recorded higher scores than the national norms in terms of total,regular and special dimensions of SW(P＜0.01);the personal-oriented interpersonal SW amid second-year students and the society-oriented moral SW amid interns are significantly lower than the national norms(P＜0.01);the interns' interpersonal SW does not vary statistically(P＞0.05).The abnormal rate of interpersonal dimension of the interns is higher than that of the first-year and second-year students,while the difference is not significant between the first-year and second-year students(P＞0.05).Conclusions:The nursing students from higher vocational schools have recorded higher scores than the national norms in most SW;with the involvement of professional factors,some profession-associated dimensions present abnormal,which may be related to the professional demand for the nursing students.
2014, 38(4): 519-521,532.
Abstract:
Objective:To explore the disease status and related factors of fatty liver and metabolic syndrome(MS) of people with advanced academic title in a Anhui medical college,and analyze their correlations.Methods:The physical examination data of people with advanced academic title in a Anhui medical college were statistically analyzed according to the diagnostic criteria recommended by the Chinese Medical Association from 2010 to 2012.The detection rates overweight of obesity,dyslipidema,high blood pressure and MS,the prevalences of fatty liver in the people were observed.Results:The detection rates of MS in three years were 23.9%(27/113),16.7%(19/114) and 14.4%(16/111),respectively,and the differences of detection rates between different genders were not statistical significance(P0.05).The dyslipidemia was the highest related factor of MS,followed by high blood pressure,overweight or obesity,and high blood glucose was the lowest.The prevalences of fatty liver in three years were 27.4%,32.5% and 35.1%,respectively,and the differences of detection rates between different genders were not statistical significances(P0.05).The fatty liver was positively correlated with triglyceride level and overweight or obesity(P0.01).Conclusions:Overweight or obesity,dyslipidemia and high blood pressure are the focus of intervention for people with MS.The related factors of MS and fatty liver are correlation.Overweight or obesity and hypertriglyceridemia may be the major risk factors of people with fatty liver.
Objective:To explore the disease status and related factors of fatty liver and metabolic syndrome(MS) of people with advanced academic title in a Anhui medical college,and analyze their correlations.Methods:The physical examination data of people with advanced academic title in a Anhui medical college were statistically analyzed according to the diagnostic criteria recommended by the Chinese Medical Association from 2010 to 2012.The detection rates overweight of obesity,dyslipidema,high blood pressure and MS,the prevalences of fatty liver in the people were observed.Results:The detection rates of MS in three years were 23.9%(27/113),16.7%(19/114) and 14.4%(16/111),respectively,and the differences of detection rates between different genders were not statistical significance(P0.05).The dyslipidemia was the highest related factor of MS,followed by high blood pressure,overweight or obesity,and high blood glucose was the lowest.The prevalences of fatty liver in three years were 27.4%,32.5% and 35.1%,respectively,and the differences of detection rates between different genders were not statistical significances(P0.05).The fatty liver was positively correlated with triglyceride level and overweight or obesity(P0.01).Conclusions:Overweight or obesity,dyslipidemia and high blood pressure are the focus of intervention for people with MS.The related factors of MS and fatty liver are correlation.Overweight or obesity and hypertriglyceridemia may be the major risk factors of people with fatty liver.
2014, 38(4): 525-527.
Abstract:
Objective:To explore the value of local injection of tumor necrosis factor(TNF)- inhibitors guided by high-frequency color Doppler ultrasound in the treatment of hip joint lesions in patients with ankylosing spondylitis.Methods:The antibody fusion protein of TNF- receptor were injected into 64 hip joint lesions in 35 patients with ankylosing spondylitis from Rheumatology department guided by color Doppler ultrasound,the hip joint space as puncturing area was used.The successful puncture number,adverse reactions,femoral head cartilage thickness before treatment and in 7 weeks after treatment and visual analogue score(VAS) of hip pain in all patients were recorded.Results:Joint space of hip joint could be clearly showed in high-frequency color Doppler ultrasound,the drug could be successfully injected into 93.8% of 64 hip jionts space at one-time.The cartilage thickness before treatment and in 7 weeks after treatment were(0.780.16)mm and(0.900.18)mm,respectively,the difference of which was statistical significance(P0.01).The VAS score before treatment and in 7 weeks after treatment were(5.800.89) and(1.670.66),respectively,the difference of which was statistical significance(P0.01).No obviously intraoperative and postoperative adverse reactions were found.Conclusions:The injection of antibody fusion protein of TNF- guided by high-frequency color Doppler ultrasound in the treatment of hip joint lesions in patients with ankylosing spondylitis is a safe and effective interventional therapy means.
Objective:To explore the value of local injection of tumor necrosis factor(TNF)- inhibitors guided by high-frequency color Doppler ultrasound in the treatment of hip joint lesions in patients with ankylosing spondylitis.Methods:The antibody fusion protein of TNF- receptor were injected into 64 hip joint lesions in 35 patients with ankylosing spondylitis from Rheumatology department guided by color Doppler ultrasound,the hip joint space as puncturing area was used.The successful puncture number,adverse reactions,femoral head cartilage thickness before treatment and in 7 weeks after treatment and visual analogue score(VAS) of hip pain in all patients were recorded.Results:Joint space of hip joint could be clearly showed in high-frequency color Doppler ultrasound,the drug could be successfully injected into 93.8% of 64 hip jionts space at one-time.The cartilage thickness before treatment and in 7 weeks after treatment were(0.780.16)mm and(0.900.18)mm,respectively,the difference of which was statistical significance(P0.01).The VAS score before treatment and in 7 weeks after treatment were(5.800.89) and(1.670.66),respectively,the difference of which was statistical significance(P0.01).No obviously intraoperative and postoperative adverse reactions were found.Conclusions:The injection of antibody fusion protein of TNF- guided by high-frequency color Doppler ultrasound in the treatment of hip joint lesions in patients with ankylosing spondylitis is a safe and effective interventional therapy means.
2014, 38(4): 528-530.
Abstract:
Objective:To explore the characteristics of lower limb deep venous blood flow of perioperative patients with pelvic tumor using color doppler flow image(CDFI).Methods:Thirty-five perioperative pelvic tumor patients with lower extremity pain and swell were were detected using CDFI.The diameter and velocity of femoral vein in patients without deepveinthrombosis(DVT) were observed,and which was reexamined at 3 to 10 days after operation.Results:DVT in 11 cases and no-DVT in 23 cases were found before operation.Compared with postoperation,the interior diameter of femoral vein widen,the velocity of femoral vein sloweddown,and the average maximum velocity of femoral vein during the quiet breathing decreased before operation(P0.01).Conclusions:It is important to examine the lower limbs vein of perioperative patients with pelvic tumor using CDFI,especially for the patients with malignancy,which can early diagnose the DVT and know the lower limb deep venous blood flow of patients.
Objective:To explore the characteristics of lower limb deep venous blood flow of perioperative patients with pelvic tumor using color doppler flow image(CDFI).Methods:Thirty-five perioperative pelvic tumor patients with lower extremity pain and swell were were detected using CDFI.The diameter and velocity of femoral vein in patients without deepveinthrombosis(DVT) were observed,and which was reexamined at 3 to 10 days after operation.Results:DVT in 11 cases and no-DVT in 23 cases were found before operation.Compared with postoperation,the interior diameter of femoral vein widen,the velocity of femoral vein sloweddown,and the average maximum velocity of femoral vein during the quiet breathing decreased before operation(P0.01).Conclusions:It is important to examine the lower limbs vein of perioperative patients with pelvic tumor using CDFI,especially for the patients with malignancy,which can early diagnose the DVT and know the lower limb deep venous blood flow of patients.
2014, 38(4): 535-537.
Abstract:
Objective:To investigate the value of the combined detection of carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),neuron specific enolase(NSE) and carcinoembryonic antigen 72-4(CA724) in the diagnosis of lung cancer.Methods:The serum levels of CEA,CYFRA21-1,NSE,CA724 in 56 cases with lung cancer(24 cases with adenocarcinoma,20 cases with squamous cell carinoma and 24 cases with small cell carcinoma),34 cases with benign pulmonary diseases and 30 healthy people were detected and analysed using electrochemiluminescence.Results:The differences of the serum levels of CEA,CYFRA21-1,NSE and CA724 in five groups were statistical significant(P0.01).The levels of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group and NSE in small cell carcinoma group were significantly higher than those in other groups(P0.01).The level of CA724 in adenocarcinoma group was significantly higher than that in control group and benign disease group(P0.01).The positive rates of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group,NSE in small cell carcinoma group and CA724 in adenocarcinoma group were higher than those in control group and benign disease group(P0.05 to P0.01).The specificities and sensitivities of the individual detection of 4 kinds of markers were 88.9% to 94.4% and 28.6% to 41.1%,respectively.The specificity and sensitivity of the combined detection of 4 kinds of markers decreased(83.3%) and increased(87.5%),respectively.Conclusions:There is certain correlation between the serum levels of CEA,CYFRA21-1,NSE and CA724 and the pathological type of lung cancer,the combined detection of which can improve the postive detection rate of lung cancer.
Objective:To investigate the value of the combined detection of carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),neuron specific enolase(NSE) and carcinoembryonic antigen 72-4(CA724) in the diagnosis of lung cancer.Methods:The serum levels of CEA,CYFRA21-1,NSE,CA724 in 56 cases with lung cancer(24 cases with adenocarcinoma,20 cases with squamous cell carinoma and 24 cases with small cell carcinoma),34 cases with benign pulmonary diseases and 30 healthy people were detected and analysed using electrochemiluminescence.Results:The differences of the serum levels of CEA,CYFRA21-1,NSE and CA724 in five groups were statistical significant(P0.01).The levels of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group and NSE in small cell carcinoma group were significantly higher than those in other groups(P0.01).The level of CA724 in adenocarcinoma group was significantly higher than that in control group and benign disease group(P0.01).The positive rates of CEA in adenocarcinoma group,CYFRA21-1 in squamous cell carcinoma group,NSE in small cell carcinoma group and CA724 in adenocarcinoma group were higher than those in control group and benign disease group(P0.05 to P0.01).The specificities and sensitivities of the individual detection of 4 kinds of markers were 88.9% to 94.4% and 28.6% to 41.1%,respectively.The specificity and sensitivity of the combined detection of 4 kinds of markers decreased(83.3%) and increased(87.5%),respectively.Conclusions:There is certain correlation between the serum levels of CEA,CYFRA21-1,NSE and CA724 and the pathological type of lung cancer,the combined detection of which can improve the postive detection rate of lung cancer.
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