神经生长因子及其受体p75在乳腺癌中的表达
The expression of nerve growth factor and its receptor p75 in breast cancer
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摘要: 目的: 探讨神经生长因子(NGF)及其低亲和力受体p75在乳腺癌中的表达及其意义.方法: 采用PV-9000免疫组织化学方法检测118例乳腺疾病患者病灶组织中NGF和p75的表达.结果: NGF在乳腺癌上皮细胞中表达,在恶性肿瘤中阳性率高于良性肿瘤(P< 0.01),在原位癌和浸润癌中阳性率差异无统计学意义(P >0.05);p75在乳腺的肌上皮细胞表达,在良性肿瘤中的阳性率高于恶性肿瘤(P< 0.01).NGF阳性率在肿瘤的分级、年龄、淋巴结转移间差异均无统计学意义(P >0.05),p75阳性率在年龄间差异无统计学意义(P >0.05),而在肿瘤的分级和淋巴结转移间表达阳性率差异均有统计学意义(P< 0.01和P< 0.05).结论: NGF可能是乳腺癌发生、发展的分子事件,但与乳腺癌的浸润性进展无关;p75可作为乳腺癌恶性程度的分子标志物.Abstract: Objective: To explore the expression and significance of nerve growth factor(NGF) and its receptor(p75) in breast cancer.Methods: The expressions of NGF and p75 in cancer tissuo of 118 patients with breast disease were detected using immunohistochemical method of PV-9000.Results: The NGF expression in mammary tumor epithelial cells was detected,the positive expression rate of NGF in malignant tumor was higher than that in benign tumor(P< 0.05),the difference of the NGF expression in situ and invasive carcinoma was not statistically significant(P >0.05).The p75 expression in the mammary gland myo-epithelial cells was detected,the positive expression rate of p75 in benign tumor was higher than that in malignant tumor(P< 0.05).The differences of the positive expression rate of NGF in tumor grade and lymph node metastasis,and patient age were not statistically significant(P >0.05).The difference of the positive expression rate of p75 in patient age was not statistically significant(P >0.05),but in tumor grade and lymph node metastasis,the differences were statistically significant(P< 0.01 and P< 0.05).Conclusions: NGF may be a molecular event of the occurrence and development of breast cancer,but it is unrelated with the invasion of breast cancer.p75 can be used as a molecular marker of malignant degree of breast cancer.
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Key words:
- breast neoplasm /
- nerve growth factor /
- p75
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