微量元素氟对小鼠甲状腺功能的影响

胡爱武; 刘小阳; 秦宜德

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

微量元素氟对小鼠甲状腺功能的影响

胡爱武 , 刘小阳 , 秦宜德

文章导航 > 蚌埠医学院学报 > 2008, 33 > 4: (392-394)

引用本文:

Citation:

微量元素氟对小鼠甲状腺功能的影响

1. 安徽医科大学生物化学与分子生物学教研室, 安徽合肥 230032;
2. 蚌埠医学院生物学教研室, 安徽蚌埠 233030;
3. 宿州学院化生系, 安徽宿州 234000

作者简介: 胡爱武(1967-),女,讲师.

中图分类号: R335.2

Effect of fluorine on triiodothyronine and thyroxin in mice

1. Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei Anhui 230032;
2. Department of Biology, Bengbu Medical College, Bengbu Anhui 233030;
3. Department of Chemistry and Biology, Suzhou College, Suzhou Anhui 234000, China
CLC number: R335.2

摘要: 目的:探讨微量元素氟及高氟补硒后对小鼠甲状腺功能的影响。方法:将80只小鼠随机分为一个对照组和三个实验组。预饲3天后,实验组分别腹腔注射20 mg/L (低氟组)、200 mg/L (高氟组)氟化钠溶液以及200 mg/L氟化钠与100 mg/L亚硒酸钠的混合溶液(高氟加硒组),对照组注射生理盐水。10天后和30天后各选取一半小鼠,观测其血清中T₃、T₄水平的差异,做短期研究和长期研究。结果:在短期影响中,低氟组的T₃、T₄水平与对照组比较有上升趋势,但无统计学意义(P>0.05);高氟组的T₃、T₄水平进一步上升,其中T₄水平显著高于对照组,差异有统计学意义(P<0.05);高氟加硒组的T₃、T₄水平与对照组比较,差异无统计学意义(P>0.05),与高氟组比较呈下降的回复趋势。在长期影响中,低氟组的T₃、T₄水平与对照组比较有所下降,高氟组的T₃、T₄水平进一步下降,但均无统计学意义(P>0.05);高氟加硒组的T₃、T₄水平与高氟组比较又有所上升,但无统计学意义(P>0.05)。结论:高氟可影响小鼠甲状腺的分泌功能,短期使其分泌功能增强,长期有使其分泌功能减弱的趋势;高氟状态下补硒后,甲状腺功能的改变有回复趋势。
- 甲状腺功能试验 /
- 氟 /
- 硒 /
- 三碘甲状腺原氨酸 /
- 甲状腺素 /
- 小鼠
Abstract: Objective: To investigate the influence of fluorine on the thyroid gland in mice.Methods: Eighty mice were randomly divided into control group and three experiment groups.The mice in control group,experiment groups with lower dose of fluorine and higher dose of fluorine group were injected physiological saline,NaF solution at 20 mg/L and 200 mg/L via peritoneal cavities,respectively.The mice in group with higher dose of fluorine mixed with selenium were injected solution containing NaF at 200 mg/L and Na₂SeO₃ at 100 mg/L via peritoneal cavities.After ten days(short-term) and thirty days(long-term),the serum levels of T₃ and T₄ in the mice were measured.Results: The serum levels of T₃ and T₄ had no obvious difference between the group with a low dose of fluorine and control group(P>0.05).The levels of T₃ and T₄ increased significantly in the group with high dose of fluorine and the level of T₄ was much higher than that in the control group(P<0.05).The levels of T₃ and T₄ had no significant differece between the group with higher dose of fluorine mixed with selenium and the control group,and the level was decreased compared with that of higher dose of fluorine group.Under long-term influence,the levels of T₃ and T₄ had no obvious difference between lower dose group and control group(P>0.05).Compared with control group,the level of T₄ of higher dose group was higher(P<0.05),while the level of T₃ was lower,but the difference was not obvious(P>0.05).The levels of T₃ and T₄ had no obvious difference between the group with higher dose of fluorine mixed with selenium and control group(P>0.05)Conclusions: Fluorine at a high dose might interfere the secretive function of thyroid gland in mice.It enhances the secretion of thyroid gland in short-term,but inhibits the secretive function in long-term.The changes of the secretive function of thyroid gland are correlative with the dose of fluorin and the time length of test.By supplying selenium,the secretive function of thyroid gland trends to come back to normal state from the disorder aroused by high dose of fluorin.

[1]	周路路 , 金国玺 , 吕高友 , 王春 , 李娟 . 硒对桥本甲状腺炎的临床疗效及氧化抗氧化系统的作用. 蚌埠医学院学报, 2019, 44(11): 1468-1472. doi: 10.13898/j.cnki.issn.1000-2200.2019.11.009
[2]	李丽 , 王鹏远 , 池莲祥 , 薛冀苏 , 郑信华 , 钟丽娣 . 微量元素硒对弥漫性毒性甲状腺肿治疗效果的影响. 蚌埠医学院学报, 2016, 41(11): 1477-1479. doi: 10.13898/j.cnki.issn.1000-2200.2016.11.023
[3]	寇泽刚 . 阿立哌唑、喹硫平和利培酮对精神分裂症患者甲状腺素水平的影响. 蚌埠医学院学报, 2015, 40(9): 1184-1185,1188. doi: 10.13898/j.cnki.issn.1000-2200.2015.09.013
[4]	郑燕 . 兔妊娠后期注射甲状腺素影响仔兔生长的相关性分析. 蚌埠医学院学报, 2013, 37(7): 789-791.
[5]	康淑霞 , 张士荣 . 急性脑梗死患者血清甲状腺激素水平的测定及其临床意义. 蚌埠医学院学报, 2007, 32(3): 349-350.
[6]	叶志恒 , 储小宏 , 贾丽 , 赵广碧 , 吴帮庆 . 聚乙二醇预处理脂血标本前后FT₃和FT₄的变化. 蚌埠医学院学报, 2008, 33(2): 225-226.
[7]	王颖 , 张宝文 , 苑讯 . 加减香砂六君子汤对功能性消化不良小鼠血清白细胞介素的影响. 蚌埠医学院学报, 2017, 42(6): 710-712. doi: 10.13898/j.cnki.issn.1000-2200.2017.06.003
[8]	杨芬 , 刘浩 , 余美玲 , 张翠玲 . 三七粉对小鼠S180移植肿瘤的抑制作用及免疫功能的影响. 蚌埠医学院学报, 2009, 34(3): 195-197.
[9]	王力 , 张梦媛 , 吕卉 , 申玲 , 张玉媛 , 赵文红 . 全氟辛酸致小鼠脾脏氧化损伤的实验研究. 蚌埠医学院学报, 2015, 40(6): 716-718. doi: 10.13898/j.cnki.issn.1000-2200.2015.06.005
[10]	邴鹏飞 . 孕妇尿氟含量等因素与新生儿先天性心脏病的关系. 蚌埠医学院学报, 2016, 41(5): 643-645. doi: 10.13898/j.cnki.issn.1000-2200.2016.05.030
[11]	黄礼年 , 陈余清 , 宋玮 , 承泽农 , 王朝夫 , 刘超 . 米诺环素抑制小鼠肺癌生长、转移及抗血管生成的研究. 蚌埠医学院学报, 2005, 30(3): 206-208.
[12]	赵修春 , 姚春艳 , 李柏青 , 徐凤珍 . 流式细胞术检测小鼠中性粒细胞吞噬功能的方法学探讨. 蚌埠医学院学报, 2004, 29(5): 388-390.
[13]	李卫鹏 , 申勇 , 胡永全 , 史桂英 , 王福庆 . NOD小鼠CD4⁺CD25⁺调节性T细胞功能变化研究. 蚌埠医学院学报, 2008, 33(6): 743-746.
[14]	金齐力 , 孙悝 , 吕小艳 , 韦莉 . 结核分枝杆菌感染对小鼠树突状细胞功能的影响. 蚌埠医学院学报, 2015, 40(9): 1145-1147,1151. doi: 10.13898/j.cnki.issn.1000-2200.2015.09.001
[15]	胡代菊 , 马珺 , 赵晶晶 , 赵小康 , 李清 , 王蓓蓓 . 参麦注射液对垂体后叶素诱发小鼠心肌缺血的保护作用. 蚌埠医学院学报, 2004, 29(3): 209-210.
[16]	楼皖玲 , 潘家华 , 周玲 , 周浩泉 . 减毒结核菌苗联用过量维生素A干预小鼠哮喘性肺炎的作用机制. 蚌埠医学院学报, 2009, 34(3): 192-194.
[17]	郗颖 , 陶明飞 , 王元元 , 陶静 . 刺五加注射液对胃肠功能障碍小鼠消化道动力的影响. 蚌埠医学院学报, 2012, 36(4): 383-385.
[18]	王淑艳 , 陈以文 , 于雪 , 刘丹彤 , 盛春瑞 , 畅洪昇 , 李丽娜 . 小鼠支气管肺泡干细胞的分离、鉴定与三维培养体系的构建. 蚌埠医学院学报, 2020, 45(1): 1-4. doi: 10.13898/j.cnki.issn.1000-2200.2020.01.001
[19]	吴良霞 , 林晓亮 , 徐敏 , 张建华 . 哮喘小鼠肺组织中趋化因子干扰素-γ诱导蛋白-10、干扰素-γ诱导单核细胞因子表达及其意义. 蚌埠医学院学报, 2009, 34(1): 15-17.
[20]	周亚妮 , 李可 , 刘丹 . 基于CLP败血症小鼠中补体C5a与白细胞介素-6相关性研究. 蚌埠医学院学报, 2017, 42(2): 148-150. doi: 10.13898/j.cnki.issn.1000-2200.2017.02.003

点击查看大图

计量

文章访问数: 3616
HTML全文浏览量: 313
PDF下载量: 4
被引次数: 0

微量元素氟对小鼠甲状腺功能的影响

作者简介: 胡爱武(1967-),女,讲师.

1. 安徽医科大学生物化学与分子生物学教研室, 安徽合肥 230032;
2. 蚌埠医学院生物学教研室, 安徽蚌埠 233030;
3. 宿州学院化生系, 安徽宿州 234000

收稿日期: 2008-01-28

关键词:

摘要: 目的:探讨微量元素氟及高氟补硒后对小鼠甲状腺功能的影响。方法:将80只小鼠随机分为一个对照组和三个实验组。预饲3天后,实验组分别腹腔注射20 mg/L (低氟组)、200 mg/L (高氟组)氟化钠溶液以及200 mg/L氟化钠与100 mg/L亚硒酸钠的混合溶液(高氟加硒组),对照组注射生理盐水。10天后和30天后各选取一半小鼠,观测其血清中T₃、T₄水平的差异,做短期研究和长期研究。结果:在短期影响中,低氟组的T₃、T₄水平与对照组比较有上升趋势,但无统计学意义(P>0.05);高氟组的T₃、T₄水平进一步上升,其中T₄水平显著高于对照组,差异有统计学意义(P<0.05);高氟加硒组的T₃、T₄水平与对照组比较,差异无统计学意义(P>0.05),与高氟组比较呈下降的回复趋势。在长期影响中,低氟组的T₃、T₄水平与对照组比较有所下降,高氟组的T₃、T₄水平进一步下降,但均无统计学意义(P>0.05);高氟加硒组的T₃、T₄水平与高氟组比较又有所上升,但无统计学意义(P>0.05)。结论:高氟可影响小鼠甲状腺的分泌功能,短期使其分泌功能增强,长期有使其分泌功能减弱的趋势;高氟状态下补硒后,甲状腺功能的改变有回复趋势。

English Abstract

Effect of fluorine on triiodothyronine and thyroxin in mice

1. Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei Anhui 230032;
2. Department of Biology, Bengbu Medical College, Bengbu Anhui 233030;
3. Department of Chemistry and Biology, Suzhou College, Suzhou Anhui 234000, China

Received Date: 2008-01-28

Abstract: Objective: To investigate the influence of fluorine on the thyroid gland in mice.Methods: Eighty mice were randomly divided into control group and three experiment groups.The mice in control group,experiment groups with lower dose of fluorine and higher dose of fluorine group were injected physiological saline,NaF solution at 20 mg/L and 200 mg/L via peritoneal cavities,respectively.The mice in group with higher dose of fluorine mixed with selenium were injected solution containing NaF at 200 mg/L and Na₂SeO₃ at 100 mg/L via peritoneal cavities.After ten days(short-term) and thirty days(long-term),the serum levels of T₃ and T₄ in the mice were measured.Results: The serum levels of T₃ and T₄ had no obvious difference between the group with a low dose of fluorine and control group(P>0.05).The levels of T₃ and T₄ increased significantly in the group with high dose of fluorine and the level of T₄ was much higher than that in the control group(P<0.05).The levels of T₃ and T₄ had no significant differece between the group with higher dose of fluorine mixed with selenium and the control group,and the level was decreased compared with that of higher dose of fluorine group.Under long-term influence,the levels of T₃ and T₄ had no obvious difference between lower dose group and control group(P>0.05).Compared with control group,the level of T₄ of higher dose group was higher(P<0.05),while the level of T₃ was lower,but the difference was not obvious(P>0.05).The levels of T₃ and T₄ had no obvious difference between the group with higher dose of fluorine mixed with selenium and control group(P>0.05)Conclusions: Fluorine at a high dose might interfere the secretive function of thyroid gland in mice.It enhances the secretion of thyroid gland in short-term,but inhibits the secretive function in long-term.The changes of the secretive function of thyroid gland are correlative with the dose of fluorin and the time length of test.By supplying selenium,the secretive function of thyroid gland trends to come back to normal state from the disorder aroused by high dose of fluorin.