腹腔镜脾脏切除6例的初步经验

鲁正; 吴斌全; 崔培元; 吴维; 吴华; 邱兆磊

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腹腔镜脾脏切除6例的初步经验

鲁正 , 吴斌全 , 崔培元 , 吴维 , 吴华 , 邱兆磊

文章导航 > 蚌埠医学院学报 > 2012, 36 > 2: (163-165)

引用本文:

Citation:

腹腔镜脾脏切除6例的初步经验

1.
蚌埠医学院第一附属医院肝胆外科,安徽蚌埠,233004

作者简介: 鲁正(1971-)，男，博士，主任医师，副教授

基金项目:

Laparoscopic splenectomy:a report of 6 cases

1.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

摘要: 目的：探讨腹腔镜脾脏切除术的可行性和安全性。方法：对6例腹腔镜脾脏切除术患者的临床资料进行回顾性分析。结果：手术时间180～260 min；术中出血量400～800 ml，患者术中均未输血；术后住院5～9 d；患者手术后均无并发症。结论：腹腔镜脾脏切除术是安全可行的，术中预防大出血是手术成功的关键。
- 脾切除术 /
- 腹腔镜术 /
- 外科手术,微创性
Abstract: Objective:To evaluate the effectiveness and toxicity of concurrent chemoradiotherapy on locally advanced esophageal carcinoma. Methods:Forty-nine cases with locally advanced esophageal carcinoma were randomized into the first group(24 cases) treated only with radiotherapy and the second group(25 cases) treated with chemoradiotherapy combined cisplatin(20 mg/m2 day 1-4) and 5-fluorouracil(500 mg/m2 day 1-5).All cases were irradiated with60CO or 6MV-X ray.The radiation dose of the first group was 60-68 Gy in tumor for 30-34 times and sustained 6.0-6.5 weeks.The radiation dose of the second group was 54-60 Gy in tumor for 27-30 times and sustained 5.5-6.0 weeks,and 50-60 Gy,25-30 times and sustaining 5.0-6.0 weeks for regional lymph nodes.The second group were injected droply with 5-fluorouracil(500 mg/m2) for 5 days and cisplatin(20 mg/m2) for 4 days. Results:The effective rates of chemoradiotherapy group and radiotherapy group were 92.00% and 79.17%,respectively,the difference of the effective rates had no statistically significance(P0.05).The 1-year,2-year overall survival rate(OS) and locoregional progression-free survival(LPFS) of chemoradiotherapy group and radiotherapy group were 68.00%,32.00% and 58.33%,20.80%,and 72.00%,36.00% and 66.62%,25.00%,respectively.The LPFS and OS had no statistically significant difference between the two groups(P0.05).The toxicity of chemoradiotherapy group was heavier than the radiotherapy group,but the most patiens were tolerable. Conclusions:The chemoradiotherapy combined cisplatin and 5-fluorouracil can enhance the survival rate of patiens with locally advanced esophageal carcinoma and the adverse response is tolerable.
- splenectomy /
- laparoscopy /
- surgical proceduresminimally invasive

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腹腔镜脾脏切除6例的初步经验

作者简介: 鲁正(1971-)，男，博士，主任医师，副教授

1. 蚌埠医学院第一附属医院肝胆外科,安徽蚌埠,233004

收稿日期: 2011-05-06
网络出版日期: 2012-02-15

基金项目:

关键词:

摘要: 目的：探讨腹腔镜脾脏切除术的可行性和安全性。方法：对6例腹腔镜脾脏切除术患者的临床资料进行回顾性分析。结果：手术时间180～260 min；术中出血量400～800 ml，患者术中均未输血；术后住院5～9 d；患者手术后均无并发症。结论：腹腔镜脾脏切除术是安全可行的，术中预防大出血是手术成功的关键。

English Abstract

Laparoscopic splenectomy:a report of 6 cases

1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2011-05-06
Available Online: 2012-02-15

Abstract: Objective:To evaluate the effectiveness and toxicity of concurrent chemoradiotherapy on locally advanced esophageal carcinoma. Methods:Forty-nine cases with locally advanced esophageal carcinoma were randomized into the first group(24 cases) treated only with radiotherapy and the second group(25 cases) treated with chemoradiotherapy combined cisplatin(20 mg/m2 day 1-4) and 5-fluorouracil(500 mg/m2 day 1-5).All cases were irradiated with60CO or 6MV-X ray.The radiation dose of the first group was 60-68 Gy in tumor for 30-34 times and sustained 6.0-6.5 weeks.The radiation dose of the second group was 54-60 Gy in tumor for 27-30 times and sustained 5.5-6.0 weeks,and 50-60 Gy,25-30 times and sustaining 5.0-6.0 weeks for regional lymph nodes.The second group were injected droply with 5-fluorouracil(500 mg/m2) for 5 days and cisplatin(20 mg/m2) for 4 days. Results:The effective rates of chemoradiotherapy group and radiotherapy group were 92.00% and 79.17%,respectively,the difference of the effective rates had no statistically significance(P0.05).The 1-year,2-year overall survival rate(OS) and locoregional progression-free survival(LPFS) of chemoradiotherapy group and radiotherapy group were 68.00%,32.00% and 58.33%,20.80%,and 72.00%,36.00% and 66.62%,25.00%,respectively.The LPFS and OS had no statistically significant difference between the two groups(P0.05).The toxicity of chemoradiotherapy group was heavier than the radiotherapy group,but the most patiens were tolerable. Conclusions:The chemoradiotherapy combined cisplatin and 5-fluorouracil can enhance the survival rate of patiens with locally advanced esophageal carcinoma and the adverse response is tolerable.