|
[2] Fong GH.Mechanisms of adaptive angiogenesis to tissue hypoxia[J].Angiogenesis,2008,11(2):121-140. |
|
[2]
|
Semenza GL.Targeting HIF-1 for cancer therapy[J].Nat Rev Cancer,2003,3(10):721-732. |
|
[3] Kunz M,Ibrahim SM.Molecular responses to hypoxia in tumor cells[J].Mol Cancer,2003,2(1):23-36. |
|
[4] Rankin EB,Giaccia AJ.The role of hypoxia-inducible factors in tumorigenesis[J].Cell Death Differ,2008,15(2):678-685. |
|
[5] Fan LF,Dong WG,Jiang CQ,et al.Role of hypoxia-inducible factor-1 and survivin in colorectal carcinoma progression[J].Int J Colorectal Dis,2008,23(11):1057-1064. |
|
[6] Denko NC.Hypoxia,HIF-1 and glucose metabolism in the solid tumour[J].Nat Rev Cancer,2008,14(8):705-713. |
|
[7] Aebersold,Burri P,Beer KT,et al.Expression of hypoxia-inducible factor-1:a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer[J].Cancer Res,2001,61(7):2911-2916. |
|
[8] Unruh A,Ressel A,Mohamed HG,et al.The hypoxia-inducible factor-1 is a negative factor for tumor therapy[J].Oncogene,2003,22(21):3213-3220. |
|
[9] Gradin K,Takasaki C,Fujii-Kuriyama Y,et al.The transcriptional activation function of the HIF2 like factor requires phosphorylation at a conserved threonine[J].J Biol Chem,2002,277(26):23508-23514. |
|
[10] Sang N,Stiehl D,Bohensky J,et al.MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300[J].J Biol Chem,2003,278(16):14013-14019. |
|
[11] Jeong HJ,Kim JB,Hong SH,et al.Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 in the inner ear[J].J Neuroimmunol,2005,163(1/2):84-91. |
|
[12] Mills CN,Joshi S,Niles RM.Expression and function of hypoxia inducible factor-1 in human melanoma under non-hypoxic conditions[J].Mol Cancer,2009,8:104. |
|
[13] Trisciuoglio D,Iervolino A,Zupi G,et al.Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells[J].Mol Biol Cell,2005,16(9):4153-4162. |
|
[14] Khandrika L,Lieberman R,Koul S,et al.Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1 levels contribute to emergence of an aggressive phenotype in prostate cancer[J].Oncogene,2009,28(9):1248-1260. |
|
[15] Hua K,Din J,Cao Q,et al.Estrogen and progestin regulate HIF-1 expression in ovarian cancer cell lines via the activation of Akt signaling transduction pathway[J].Oncol Rep,2009,21(4):893-898. |
|
[16] Liu CJ,Shi YQ,Du YL,et al,Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK[J].Exp Cell Res,2005,309(2):410-418. |
|
[17] Gao N,Shen L,Zhang Z,et al.Arsenite induces HIF-1 and VEGF through PI3K,Akt and reactive oxygen species in DU145 human prostate carcinoma cells[J].Mol Cell Biochem,2004,255(1/2):33-45. |
|
[18] Zhong H,Chiles K,Feldser D,et al,Modulation of hypoxia-inducible factor 1 expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells:implications for tumor angiogenesis and therapeutics[J].Cancer Res,2000,60(6):1541-1545. |
|
[19] Sun HL,Liu YN,Huang YT,et al.YC-1 inhibits HIF-1 expression in prostate cancer cells:contribution of Akt/NF-B signaling to HIF-1 accumulation during hypoxia YC-1 reduced HIF-1 in PC-3 cells[J].Oncogene,2007,26(1):3941-3951. |
|
[20] Fang J,Xia C,Cao ZX,et al.Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and H2/p53 pathways[J].FASEB J Res Commun,2005,19(3):342-353. |
|
[21] Mirzoeva S,Kim ND,Chiu K,et al.Inhibition of HIF-1 and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells[J].Mol Carcinog,2008,47(9):686-700. |
|
[22] Khandrika L,Lieberman R,Koul S,et al.Hypoxia associated p38 mitogen-activated protein kinase mediated androgen receptor activation and increased HIF-1 levels contribute to emergence of an aggressive phenotype in prostate cancer[J].Oncogene,2009,28(9):1248-1260. |
|
[23] 郭花,朱金水,王龙,等,PI3K/Akt信号通路及HIF-1在胃癌中的表达[J].现代肿瘤医学,2009,17(10):1913-1916. |
|
[24] Lee BL,Kim WH,Jung J,et al,A hypoxia-independent up-regulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancer[J].Carcinogenesis,2008,29(1):44-51. |
|
[25] Ardyanto TD,Osaki M,Tokuyasu N,et al.CoCl2-induced HIF-1 expression correlates with proliferation and apoptosis in MKN-1 cells:a possible role for the PI3K/Akt pathway[J].Int J Oncol,2006,29(3):549-555. |
|
[26] Kobayashi I,Semba S,Matsuda Y,et al.Significance of Akt phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinoma[J].Pathobiology,2006,73(1):8-17. |
|
[27] Lin MT,Kuo IH,Chang CC,et al.Involvement of hypoxia-inducing factor-1-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion[J].J Biol Chem,2008,283(23):15807-15815. |
|
[28] Majumder PK,Febbo PG,Bikoff R,et al.mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways[J].Nat Med,2004,10(5):594-601. |
|
[29] Hudson CC,Liu M,Chiang GG,et al.Regulation of hypoxia-inducible factor 1 expression and function by the mammalian target of rapamycin[J].Mol Cell Biol,2002,22(20):7004-7014. |
|
[30] Flgel D,Grlach A,Michiels C,et al.Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor1 and mediates its destabilization in a VHL-independent manner[J].Mol Cell Biol,2007,27(9):3253-3265. |
|
[31] Rho JK,Choi YJ,Lee JK,et al.Gefitinib circumvents hypoxia-induced drug resistance by the modulation of HIF-1[J].Oncol Rep,2009,21(3):801-807. |
|
[32] Hsieh FC,Cheng G,Lin J,et al.Evaluation of potential STAT3 regulated genes in human breast cancer[J].Biochem Biophys Res Commun,2005,335(2):292-299. |
|
[33] Niu G,Briggs J,Deng J,et al.Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1 RNA expression in both tumor cells and tumor-associated myeloid cells[J].Mol Cancer Res,2008,6(7):1099-1105. |
|
[34] Xu Q,Briggs J,Park S,et al.Targeting STAT3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways[J].Oncogene,2005,24(36):5552-5560. |
|
[35] Tacchini L,De Ponti C,Matteucci E,et al.Hepatocyte growth factor-activated NF-B regulates HIF-1 activity and ODC expression,implicated in survival,differently in different carcinoma cell lines[J].Carcinogenesis,2004,25(11):2089-2100. |
|
[36] Hurwitz H,Fehrenbacher L,Novotny W,et al.Bevacizumab plus irinotecan,fluorouracil,and leucovorin for metastatic colorectal cancer[J].N Engl J Med,2004,350(23):2335-2342. |
|
[37] Zhu LY,Chen P,Jiang YS.Expression of HIF-1 and VEGF in non small cell lung cancer and relationship between them and tumor angiogenesis[J].Chin J Mod Med,2005,15(7):1017-1019. |
|
[38] Lu Y,Liang K,Li XQ,et al.Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1[J].Mol Cancer,2007,6(1):63-76. |
|
[39] Liu YV,Baek JH,Zhang H,et al.RACK1 competes with HSP90 for binding to HIF-1 and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1[J].Mol Cell,2007,25(2):207-217. |
|
[40] Liu YV,Hubbi ME,Pan F,et al.Calcineurin promotes hypoxia-inducible factor 1 expression by dephosphorylating RACK1 and blocking RACK1 dimerization[J].J Biol Chem,2007,282(51):37064-37073. |
|
[41] Amir S,Wang R,Simons JW,et al.SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation[J].J Biol Chem,2009,284(17):11142-11151. |
点击查看大图
下载:
