高迁移率族蛋白-1与家兔急性一氧化碳中毒迟发性脑病的关系

王慧峰; 何先弟

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高迁移率族蛋白-1与家兔急性一氧化碳中毒迟发性脑病的关系

王慧峰 , 何先弟

文章导航 > 蚌埠医学院学报 > 2011, 36 > 2: (124-126,129)

引用本文:

Citation:

高迁移率族蛋白-1与家兔急性一氧化碳中毒迟发性脑病的关系

王慧峰,
何先弟^,

蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

作者简介: 王慧峰(1978-),女,回族,硕士研究生,主治医师.

通讯作者: 何先弟, 主任医师.bbyfyhxd@sina.com

中图分类号: R977.6

Relationship between high mobility group protein-1 and delayed neuropsychological sequelae after acute CO poisoning

WANG Hui-feng,
HE Xian-di^,

ICU, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Corresponding author: HE Xian-di, 主任医师.bbyfyhxd@sina.com

CLC number: R977.6

摘要: 目的:通过动态观测急性一氧化碳(CO)中毒后血浆高迁移率族蛋白-1(HMGB-1)含量的变化,探讨HMGB-1与迟发性脑病发生的相关性及可能作用机制。方法:普通级健康家兔24只,随机分为对照组、急性CO中毒迟发性脑病组(模型组)和正丁酸钠预处理组(干预组),每组各8只。家兔腹腔连续间隔注射高纯CO气体制备急性CO中毒迟发性脑病模型,造模结束后1、3、6、12、24 h及3、7、14、21天各时间点分别耳缘静脉采血检测HMGB-1含量。结果:血浆HMGB-1含量,在造模结束3 h,模型组与对照组比较,差异有统计学意义(P < 0.05),6 h至21天,模型组较对照组差异均有统计学意义(P < 0.01),而干预组较对照组差异无统计学意义(P > 0.05);在造模结束6 h至21天,染毒家兔(模型组与干预组)最终形成迟发性脑病组较未形成组差异也均有统计学意义(P < 0.01)。结论:早期血浆HMGB-1含量与迟发性脑病的发生呈高度相关,且HMGB-1在迟发性脑病的形成过程中发挥至关重要的作用。
- 高迁移率族蛋白-1 /
- CO中毒 /
- 迟发性脑病 /
- 正丁酸钠
Abstract: Objective: To observe the changes of plasma high mobility group protein -1 (HMGB-1) in rabbits after acute CO poisoning dynamically,discuss the association between HMGB-1 and delayed neuropsychological sequelae,and to analyze its possible mechanism in the course of the disease. Methods: Twenty-four healthy rabbits were randomly divided into control group,delayed neuropsychological sequelae after acute CO poisoning group (model group),and sodium butyrate pretreatment group (intervention group),8 in each. The rabbits were injected continuously interval high purity CO gas intraperitoneally to prepare the model of delayed neuropsychological sequelae after acute CO poisoning. After the end of modeling,1,3,6,12,24 h,and 3,7,14,21 d,blood was drawn from ear vein each time to test the levels of HMGB-1. Results: The plasma HMGB-1 levels at 3 h after the end of modeling in model group had statistical difference in contrast to control group (P < 0.05). From 6 h to 21 d after the end of modeling,the differences between model group and control group were all significance (P < 0.01),while were not statistical difference between intervention group and control group (P > 0.05); from 6 h to 21 d,in poisoned rabbits (model group and intervention group),the rate of delayed encephalopathy was significant difference compared to no encephalopathy happening (P < 0.01). Conclusions: Early plasma HMGB-1 levels are highly correlated with delayed neuropsychological sequelae after acute CO poisoning, and HMGB-1 can play a crucial role in the formation of delayed encephalopathy.
- high mobility group protein-1 /
- CO poisoning /
- neuropsychological sequelae /
- sodium butyrate

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高迁移率族蛋白-1与家兔急性一氧化碳中毒迟发性脑病的关系

王慧峰
何先弟^,

通讯作者: 何先弟, 主任医师.bbyfyhxd@sina.com

作者简介: 王慧峰(1978-),女,回族,硕士研究生,主治医师.

蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

收稿日期: 2010-07-18

关键词:

摘要: 目的:通过动态观测急性一氧化碳(CO)中毒后血浆高迁移率族蛋白-1(HMGB-1)含量的变化,探讨HMGB-1与迟发性脑病发生的相关性及可能作用机制。方法:普通级健康家兔24只,随机分为对照组、急性CO中毒迟发性脑病组(模型组)和正丁酸钠预处理组(干预组),每组各8只。家兔腹腔连续间隔注射高纯CO气体制备急性CO中毒迟发性脑病模型,造模结束后1、3、6、12、24 h及3、7、14、21天各时间点分别耳缘静脉采血检测HMGB-1含量。结果:血浆HMGB-1含量,在造模结束3 h,模型组与对照组比较,差异有统计学意义(P < 0.05),6 h至21天,模型组较对照组差异均有统计学意义(P < 0.01),而干预组较对照组差异无统计学意义(P > 0.05);在造模结束6 h至21天,染毒家兔(模型组与干预组)最终形成迟发性脑病组较未形成组差异也均有统计学意义(P < 0.01)。结论:早期血浆HMGB-1含量与迟发性脑病的发生呈高度相关,且HMGB-1在迟发性脑病的形成过程中发挥至关重要的作用。

English Abstract

Relationship between high mobility group protein-1 and delayed neuropsychological sequelae after acute CO poisoning

WANG Hui-feng
HE Xian-di^,

Corresponding author: HE Xian-di, 主任医师.bbyfyhxd@sina.com

ICU, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2010-07-18

Abstract: Objective: To observe the changes of plasma high mobility group protein -1 (HMGB-1) in rabbits after acute CO poisoning dynamically,discuss the association between HMGB-1 and delayed neuropsychological sequelae,and to analyze its possible mechanism in the course of the disease. Methods: Twenty-four healthy rabbits were randomly divided into control group,delayed neuropsychological sequelae after acute CO poisoning group (model group),and sodium butyrate pretreatment group (intervention group),8 in each. The rabbits were injected continuously interval high purity CO gas intraperitoneally to prepare the model of delayed neuropsychological sequelae after acute CO poisoning. After the end of modeling,1,3,6,12,24 h,and 3,7,14,21 d,blood was drawn from ear vein each time to test the levels of HMGB-1. Results: The plasma HMGB-1 levels at 3 h after the end of modeling in model group had statistical difference in contrast to control group (P < 0.05). From 6 h to 21 d after the end of modeling,the differences between model group and control group were all significance (P < 0.01),while were not statistical difference between intervention group and control group (P > 0.05); from 6 h to 21 d,in poisoned rabbits (model group and intervention group),the rate of delayed encephalopathy was significant difference compared to no encephalopathy happening (P < 0.01). Conclusions: Early plasma HMGB-1 levels are highly correlated with delayed neuropsychological sequelae after acute CO poisoning, and HMGB-1 can play a crucial role in the formation of delayed encephalopathy.