Stat3与肿瘤的关系研究进展
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摘要: Stat3是转录信号转导子与激活子家族STATs的重要成员,广泛表达于不同类型的细胞和组织中,介导多种细胞因子和生长因子的信号向细胞核转导,影响众多靶基因的转录,Stat3持续激活可导致细胞异常增殖和恶性转化,目前已被公认为癌基因。本文就Stat3的结构及其在肿瘤发生、发展和基因治疗中的进展作一综述。
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