Livin基因与消化道肿瘤的研究进展
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摘要: 肿瘤的发生、发展与细胞增殖和凋亡失衡密切相关。凋亡调控失常导致的细胞增殖过度和凋亡不足是肿瘤形成的重要机制之一,也是影响肿瘤治疗及预后的重要因素。
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[1] Salvesen GS,Duckett CS.IAP proteins: blocking the road to death's door[J].Nat Rev Mol Cell Biol,2002,3( 6):401-410. [2] Lin JH,Deng G,Huang Q,et al.KIAP,a novel member of the inhibitor of apoptosis protein family[J].Biochem Biophys Res Commun, 2000,279( 3):820-831. [3] Vucic D,Stennicke HR,Pisabarro MT,et al.ML-IAP,a novel inhibitor of apoptosis that is preferentially expressed in human melanomas[J].Curr Biol,2000, 10( 21):1359-1366. [4] Kasof GM,Gomes BC.Livin,a novel inhibitor of apoptosis protein family member[J].J Biol Chem, 2001,276( 5):3238-3246. [5] Ashhab Y,Alian A,Polliack A, et al.Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern[J].FEBS Lett,2001,495( 1 /2):56-60. [6] Ka H,Hunt JS.Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas[J].Am J Pathol,2003, 163(2):413-422. [7] Nachmias B,Lazar I,Elmalech M,et al.Subcellular localization determines the delicate balance between the anti- and proapoptotic activity of Livin [J].Apoptosis,2007,12 ( 7 ):1129-1142. [8] Zhao Y,Deng X,Wang Q.Expression and clinical significance of apoptosis associated genes Livin and smac /DIABLO in human gastric carcinomas[J].CJC,2009,28( 6):593-601. [9] 李日恒.Livin 和PTEN 在结直肠癌组织中的表达及意义[J].中国中西医结合急救杂志,2009,16( 4):247-248. [10] Sanna MG,da Silva Correia J,Ducrey O, et al.IAP suppression of apoptosis involves distinct mechanisms: the TAK1 /JNK1 signaling cascade and Caspase inhibition[J].Mol Cell Biol, 2002,22( 6):1754-1766. [11] Vucic D,Frankin MC,Walweber HJ, et al.Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP [J].Biochem J,2005, 385( Pt1):11-20. [12] Ma L,Huang Y,Song Z,et al.Livin promotes Smac /DIABLO degradation by ubiquitin-proteasome pathway [J].Cell DeathDiffer, 2006, 13(12):2079-2088. [13] 韩振东,张忠太,任海,等.荧光定量PCR 法检测食管癌中Livin 基因的临床研究[J].肿瘤研究与临床,2009,21 ( 5):317-319. [14] Wang TS,Ding QQ,Guo RH, et al.Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNAmediated silencing of livin gene[J].Biomed Pharmacother,2010,64( 5):333-338. [15] Yagihashi A,Asanuma K,Tsuji N,et al.Detection of anti-livin antibody in gastrointestinal cancer patients[J].Clin Chem, 2003,49(7):1206-1208. [16] Liu C,Wu XH,Luo CL, et al.Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via amechanism involving caspase 3[J].J Exp Clin Cancer Res,2010,29: 63. [17] 陈鹏,孔令斌,王春松,等.siRNA 沉默Livin 基因对胃癌细胞生长、凋亡的影响[J].世界华人消化杂志,2009,17 ( 13 ):1346-1349. [18] Wang X,Xu J,Ju S,et al.Livin gene plays a role in drug resistance of colon cancer cells [J].Clin Biochem,2010,43( 7 /8):655-660. [19] El Ali Z,Grzymisbawski M,Majewski P,et al.Anti-livin antibodies: novel markers of malignant gastrointestinal cancers[J].Pol Arch Med Wewn,2010,120( 1 /2):26-29.
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