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幽门螺杆菌(Helicobacter pylori,HP)是一种革兰阴性杆菌,通常寄生于人体胃部,并与消化道溃疡、慢性胃炎、胃黏膜相关淋巴组织、淋巴瘤等胃部疾病密切相关[1]。有报道[2]称HP是一种致癌物,长期的感染而未能彻底根治可诱发胃癌。近年来通过对HP不断深入地研究,发现HP感染可能与多种胃肠系统外疾病的发生相关,如心脑血管疾病、肝胆疾病等。同型半胱氨酸(Hcy)是一种含硫氨基酸,自从MCCULLY等[3]首次报道,高同型半胱氨酸血症(HHcy)可能是引起动脉粥样硬化的危险因素之一,而且HP感染可能是导致HHcy的因素之一。同时有研究[4]发现, HP感染可通过对血脂代谢的影响而诱发冠心病(CHD),其中胆固醇尤其是高密度脂蛋白胆固醇(HDL-C)的降低和低密度脂蛋白胆固醇(LDL-C)的升高是CHD发生和进展的前提。本研究通过对HP感染者和HP未感染者的Hcy及血脂各项指标的测定和比较,探讨HP感染与Hcy及血脂的关系。现作报道。
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HP感染组HHcy检出率为19.61%(10/51),HP未感染组HHcy检出率为5.88%(3/51),2组间差异有统计学意义(P < 0.05);HP感染组的TC、HDL-C、LDL-C异常检测率均高于HP未感染组(P < 0.05~P < 0.01)(见表 1)。
分组 n Hcy升高 TC升高 TG升高 HDL-C降低 LDL-C升高 HP感染组 51 10(19.61) 8(15.69) 13(25.49) 23(45.10) 17(33.33) HP未感染组 51 3(5.88) 1(1.96) 15(29.41) 13(25.49) 5(9.80) χ2 — 4.32 5.97 0.18 4.29 8.35 P — <0.05 <0.05 >0.05 <0.05 <0.01 表 1 HP感染组、HP未感染组病人血清Hcy及血脂异常情况的比较[n;百分率(%)]
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HP感染组病人血清TC、TG的水平均高于HP未感染组,但差异无统计学意义(P>0.05);HP感染组的Hcy和LDL-C水平均高于HP未感染组(P < 0.05);HP感染组的HDL-C水平低于HP未感染组(P < 0.05)(见表 2)。
分组 n Hcy/(μmol/L) TC/(mmol/L) TG/(mmol/L) HDL-C/(mmol/L) LDL-C/(mmol/L) HP感染组 51 12.80±10.22 4.51±1.41 1.71±2.42 1.10±0.30 2.63±1.22 HP未感染组 51 8.90±4.64 4.07±0.98 1.48±0.88 1.26±0.35 2.14±0.76 t — 2.47 1.82 0.65 -2.52 2.45 P — <0.05 >0.05 >0.05 <0.05 <0.05 表 2 HP感染组、HP未感染组病人血清Hcy及血脂水平比较(x±s)
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HP水平与病人体内的Hcy、TC、LDL-C水平均呈正相关关系(r=0.248、0.243、0.272,P < 0.05)。
幽门螺杆菌感染对同型半胱氨酸及血脂的影响探讨
Investigation of the influence of Helicobacter pylori infection on the levels of homocysteine and blood lipid
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摘要:
目的探讨幽门螺杆菌(Helicobacter pylori,HP)感染对同型半胱氨酸(homocysteine,Hcy)及血脂的影响。 方法选取102例住院病人,根据有无HP感染情况将其分为HP感染组和HP未感染组,分别测定2组Hcy水平、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平,分析HP感染对Hcy及血脂水平的影响以及相关性。 结果HP感染组高同型半胱氨酸血症(HHcy)检出率为19.61%(10/51),高于HP未感染组的5.88%(3/51)(P < 0.05);HP感染组的TC、HDL-C、LDL-C异常检测率均高于HP未感染组(P < 0.05~P < 0.01)。HP感染组病人血清TC、TG的水平均高于HP未感染组,但差异无统计学意义(P>0.05);HP感染组的Hcy和LDL-C水平均高于HP未感染组(P < 0.05),而HDL-C水平低于HP未感染组(P < 0.05)。HP抗体水平与病人体内的Hcy、TC、LDL-C水平呈正相关关系(r=0.248、0.243和0.272,P < 0.05)。 结论HP感染与HHcy的发生及血脂水平的异常密切相关,并能增加心血管疾病的风险。 Abstract:ObjectiveTo explore the influence of Helicobacter pylori(HP) infection on the levels of homocysteine(Hcy) and blood lipid. MethodsOne hundred and two hospitalized patients were divided into the HP infection group and HP uninfection group according to the HP infection situation, respectively.The levels of Hcy, total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C), were detected in two groups.The influence of HP infection on the levels of Hcy and blood lipid between two groups was compared, and the correlation between the level of Hcy and blood lipid was analyzed in two groups. ResultsThe detection rates of HHcy in HP infection group and HP uninfection group were 19.61%(10/51) and 5.88%(3/51), respectively, and the difference of which was statistically significant(P < 0.05).The abnormal detection rates of the levels of TC, HDL-C and LDL-C in HP infection group were higher than those in HP uninfection group(P < 0.05 to P < 0.01).The levels of TC and TG in HP infection group were higher compared with the HP uninfection group, and the difference of which was not statistically significant(P>0.05).The levels of Hcy and LDL-C in HP infection group were higher than those in HP uninfection group(P < 0.05).The level of HDL-C in HP infection group was lower than that in HP uninfection group(P < 0.05).HP antibody level was positively correlated with the levels of Hcy, TC and LDL-C(P < 0.05). ConclusionsHP infection is closely related to the occurrence of HHcy, and the abnormal level of blood lipid, can lead to the risk increasing of cardiovascular disease. -
Key words:
- blood lipid /
- Helicobacter pylori /
- homocysteine /
- cardiovascular disease
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表 1 HP感染组、HP未感染组病人血清Hcy及血脂异常情况的比较[n;百分率(%)]
分组 n Hcy升高 TC升高 TG升高 HDL-C降低 LDL-C升高 HP感染组 51 10(19.61) 8(15.69) 13(25.49) 23(45.10) 17(33.33) HP未感染组 51 3(5.88) 1(1.96) 15(29.41) 13(25.49) 5(9.80) χ2 — 4.32 5.97 0.18 4.29 8.35 P — <0.05 <0.05 >0.05 <0.05 <0.01 表 2 HP感染组、HP未感染组病人血清Hcy及血脂水平比较(x±s)
分组 n Hcy/(μmol/L) TC/(mmol/L) TG/(mmol/L) HDL-C/(mmol/L) LDL-C/(mmol/L) HP感染组 51 12.80±10.22 4.51±1.41 1.71±2.42 1.10±0.30 2.63±1.22 HP未感染组 51 8.90±4.64 4.07±0.98 1.48±0.88 1.26±0.35 2.14±0.76 t — 2.47 1.82 0.65 -2.52 2.45 P — <0.05 >0.05 >0.05 <0.05 <0.05 -
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