人端粒酶逆转录酶与肿瘤相关性的研究进展

曹渊; 沈慧玲; 许文林

doi:10.13898/j.cnki.issn.1000-2200.2015.03.042

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人端粒酶逆转录酶与肿瘤相关性的研究进展

曹渊 , 沈慧玲 , 许文林

文章导航 > 蚌埠医学院学报 > 2015, 40 > 3: (411-413)

引用本文:

Citation:

人端粒酶逆转录酶与肿瘤相关性的研究进展

江苏大学附属人民医院肿瘤科, 江苏镇江 212002

作者简介: 曹渊(1988-),男,硕士研究生.

基金项目:
江苏省自然科学基金资助项目(BK2010332)

81101677)

国家自然科学基金资助项目(81070423
中图分类号: R730

- 肿瘤 /
- 端粒 /
- 端粒酶 /
- 人端粒酶逆转录酶 /
- 综述

[1]	Blackburn EH.Structure and function of telomeres[J].Nature,1991,350(6319):569-573.
[2]	Lu W,Zhang Y,Liu D,et al.Telomeres-structure,function,and regulation[J].Exp Cell Res,2013,319(2):133-141.
[3]	Cohen SB,Graham ME,Lovrecz GO,et al.Protein composition of catalytically active human telomerase from immortal cells[J].Science,2007,315(5820):1850-1853.
[4]	Fabricius EM,Kruse-Boitschenko U,Khoury R,et al.Immunohistochemical determination of the appropriate anti-hTERT antibodies for in situ detection of telomerase activity in frozen sections of head and neck squamous cell carcinomas and tumor margin tissues[J].Int J Oncol,2009,34(5):1257-1279.
[5]	Bryce LA,Morrison N,Hoare SF,et al.Mapping of the gene for the human telomerase reverse transcriptase,hTERT,to chromosome 5p15.33 by fluorescence in situ hybridization[J].Neoplasia,2000,2(3):197-201.
[6]	Cong YS,Wen J,Bacchetti S.The human telomerase catalytic subunit hTERT:organization of the gene and characterization of the promoter[J].Hum Mol Genet,1999,8(1):137-142.
[7]	Michael D,Gregory WP,Trygve OT,et al.Mapping of the Gene for the Human Telomerase Reverse Transcriptase,hTERT,to Chromosome 5p15.33 by Fluorescence in Situ Hybridization Regulation of the human catalytic subunit of telomerse(hTERT)[J].Gene,2012,498(2):135-146.
[8]	Kyo S,Takakura M,Fujiwara T,et al.Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers[J].Cancer Sci,2008,99(8):1528-1538.
[9]	Dhaene K,Wauters J,Weyn B,et al.Expression profile of telomerase subunits in human pleural mesothelioma[J].J Pathol,2000,190(1):80-85.
[10]	Rafnar T,Sulem P,Stacey SN,et al.Sequence variants at the TERT-CLPTM1L locus associate with many cancer types[J].Nat Genet,2009,41(2):221-227.
[11]	Kawai T,Hiroi S,Nakanishi K,et al.Telomere length and telomerase expression in atypical adenomatous hyperplasia and small bronchioloalveolar carcinoma of the lung[J].Am J Clin Pathol,2007,127(2):254-262.
[12]	Rosa MI,Medeiros LR,Bozzetti MC,et al.Accuracy of telomerase in cervical lesions:a systematic review[J].Int J Gynecol Cancer,2007,17(6):1205-1214.
[13]	Ge L,Shao W,Zhang Y,et al.RNAi targeting of hTERT gene expression induces apoptosis and inhibits the proliferation of lung cancer cells[J].Oncol Lett,2011,2(6):1121-1129.
[14]	Cha N,Li XY,Zhao YJ,et al.hTERT gene amplification and clinical significance in pleural effusions of patients with lung cancer[J].Clin Lung Cancer,2012,13(6):494-499.
[15]	Maraei AA,Hatta AZ,Shiran MS,et al.Human telomerase reverse transcriptase expression in ovarian tumors[J].Indian J Pathol Microbiol,2012,55(2):187-191.
[16]	Tantbirojn P,Triratanachat S,Trivijitsilp P,et al.Human telomerase reverse transcriptase(hTERT) expression in borderline ovarian tumors:an immunohistochemical study[J].J Med Assoc Thai,2009,92(3):308-314.
[17]	Kammori M,Kanauchi H,Nakamura K,et al.Demonstration of human telomerase reverse transcriptase in human colorectal carcinomas by in situ hybridization[J].Int J Oncol,2002,20(1):15-21.
[18]	Avci CB,Yilmaz S,Dogan ZO,et al.Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells[J].Hematology,2011,16(5):303-307.
[19]	Cui J,Cui L,Liu Q,et al.Dendritic cells transfected with lentiviral vector-encoding hTERT peptide augment antitumor T cell response in vitro[J].Mol Med Rep,2012,5(1):103-107.
[20]	姚小宝,王晓侠,张少强,等.干扰hTERT基因慢病毒载体对人鼻咽癌细胞的生长抑制作用[J].临床耳鼻喉头颈外科杂志,2011,25(20):939-943.
[21]	Shin JS,Foo T,Hong A,et al.Telomerase expression as a predictive marker of radiotherapy response in rectal cancer[J].Pathology,2012,44(3):209-215.
[22]	Tan J,Zhou X,Zhu H.hTERT-siRNA could potentiate the cytotoxic effect of gemcitabine to pancreatic cancer cells Bxpc-3[J].Exp Clin Transplant,2012,10(4):386-393.
[23]	Noureini SK,Wink M.Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation[J].Asian Pac J Cancer Prev,2012,13(5):2305-2309.
[24]	Jacob D,Davis JJ,Zhang L,et al.Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter[J].Cancer Gene Ther,2005,12(2):109-115.
[25]	Mizuno H,Honda M,Shirasaki T,et al.Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma[J].Liver Int,2012,32(7):1146-1155.
[26]	Kang Y,Zhang J,Sun P,et al.Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer[J].Int J Clin Oncol,2013,18(3):478-488.
[27]	Kawai J,Kodera Y,Fujiwara M,et al.Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach[J].Hepatogastroenterology,2005,52(63):959-964.
[28]	March-Villalba JA,Martinez-Jabaloyas JM,Herrero MJ,et al.Cell-free circulating plasma hTERT mRNA is a useful marker for prostate cancer diagnosis and is associated with poor prognosis tumor characteristics[J].PLoS ONE,2012,7(8):e43470.
[29]	Bertorelle R,Briarava M,Rampazzo E,et al.Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer[J].Br J Cancer,2013,108(2):278-284.
[30]	Ling X,Wen L,Zhou Y.Role of mitochondrial translocation of telomerase in hepatocellular carcinoma cells with multidrug resistance[J].Int J Med Sci,2012,9(7):545-554.
[31]	李莉,熊永炎,刘琳,等.非小细胞肺癌组织中hTERT,MDRI和MRPmRNA与C-myc蛋白的表达及相关性研究[J].癌症,2005,24(1):53-57.
[32]	Zhong YQ,Xia ZS,Fu YR,et al.Knockdown of hTERT by SiRNA suppresses growth of Capan-2 human pancreatic cancer cell via the inhibition of expressions of Bcl-2 and COX-2[J].J Dig Dis,2010,11(3):176-184.

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