单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的疗效观察

刘轩先; 严利刚

doi:10.13898/j.cnki.issn.1000-2200.2017.03.006

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单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的疗效观察

刘轩先 , 严利刚

文章导航 > 蚌埠医学院学报 > 2017, 42 > 3: (302-304,308)

引用本文:

Citation:

单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的疗效观察

安徽省蚌埠市第一人民医院皮肤科, 233000

作者简介: 刘轩先(1982-),女,主治医师.

中图分类号: R752.12

Effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster

Department of Dermatology, The First People's Hospital of Bengbu, Bengbu Anhui 233000, China
CLC number: R752.12

摘要: 目的：评估单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的临床疗效，探讨带状疱疹后遗神经痛（PHN）发生的影响因素。方法：183例急性带状疱疹病人随机分为观察组（单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗，77例）和对照组（单磷酸阿糖腺苷联合窄谱中波紫外线治疗，106例）。对2组疱疹指标、疼痛视觉模拟评分、综合疗效及PHN的发生率进行分析。结果：观察组病人止疱时间、结痂时间和脱痂时间均明显短于对照组（P<0.01）；治疗10 d后观察组疼痛视觉模拟评分低于对照组（P<0.01）；观察组治疗总有效率高于对照组（P<0.05），观察组1个月及3个月PHN的发生率均低于对照组（P<0.05）。多因素logistic回归分析显示，年龄、治疗前疼痛视觉模拟评分及是否为对照组均为PHN发生的独立危险因素（P<0.05~P<0.01）。结论：单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹疗效显著，并且可以预防PHN的发生。
- 带状疱疹 /
- 后遗神经痛 /
- LED光动力 /
- 单磷酸阿糖腺苷 /
- 窄谱中波紫外线
Abstract: Objective:To evaluate the clinical efficacy of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster,and investigate the influencing factors of postherpetic neuralgia(PHN).Methods:One hundred and eighty-two patients with acute herpes zoster were randomly divided into the observation group(77 cases treated with vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics) and control group(106 cases treated with vidarabine monophosphate combined with narrow-band ultraviolet).The indicators of herpes,visual analogue scale(VAS) score,comprehensive curative effects and incidence rates of postherpetic neuralgia between two groups were analyzed.Results:The times of response,scab form and decrustation in observation group were significantly shorter than those in control group(P<0.01).The VAS score after 10 days of treatment in observation group was lower than that in control group(P<0.01).The total effective rate in observation group was higher than that in control group(P<0.05),and the incidence rates of PHN at 1 month or 3 months of treatment in observation group were lower than that in control group(P<0.05).Multivariate logistic regression analysis showed that the age and VAS score before treatment were the independent risk factor of PHN(P<0.05 to P<0.01).Conclusions:The effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster is significant,which can prevent the incidence of PHN.
- herpes zoster /
- postherpetic neuralgia /
- LED photodynamics /
- vidarabinemonophosphate /
- narrow-band ultraviolet

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单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的疗效观察

作者简介: 刘轩先(1982-),女,主治医师.

安徽省蚌埠市第一人民医院皮肤科, 233000

收稿日期: 2016-12-26

关键词:

摘要: 目的：评估单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的临床疗效，探讨带状疱疹后遗神经痛（PHN）发生的影响因素。方法：183例急性带状疱疹病人随机分为观察组（单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗，77例）和对照组（单磷酸阿糖腺苷联合窄谱中波紫外线治疗，106例）。对2组疱疹指标、疼痛视觉模拟评分、综合疗效及PHN的发生率进行分析。结果：观察组病人止疱时间、结痂时间和脱痂时间均明显短于对照组（P<0.01）；治疗10 d后观察组疼痛视觉模拟评分低于对照组（P<0.01）；观察组治疗总有效率高于对照组（P<0.05），观察组1个月及3个月PHN的发生率均低于对照组（P<0.05）。多因素logistic回归分析显示，年龄、治疗前疼痛视觉模拟评分及是否为对照组均为PHN发生的独立危险因素（P<0.05~P<0.01）。结论：单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹疗效显著，并且可以预防PHN的发生。

English Abstract

Effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster

Department of Dermatology, The First People's Hospital of Bengbu, Bengbu Anhui 233000, China

Received Date: 2016-12-26

Abstract: Objective:To evaluate the clinical efficacy of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster,and investigate the influencing factors of postherpetic neuralgia(PHN).Methods:One hundred and eighty-two patients with acute herpes zoster were randomly divided into the observation group(77 cases treated with vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics) and control group(106 cases treated with vidarabine monophosphate combined with narrow-band ultraviolet).The indicators of herpes,visual analogue scale(VAS) score,comprehensive curative effects and incidence rates of postherpetic neuralgia between two groups were analyzed.Results:The times of response,scab form and decrustation in observation group were significantly shorter than those in control group(P<0.01).The VAS score after 10 days of treatment in observation group was lower than that in control group(P<0.01).The total effective rate in observation group was higher than that in control group(P<0.05),and the incidence rates of PHN at 1 month or 3 months of treatment in observation group were lower than that in control group(P<0.05).Multivariate logistic regression analysis showed that the age and VAS score before treatment were the independent risk factor of PHN(P<0.05 to P<0.01).Conclusions:The effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster is significant,which can prevent the incidence of PHN.