连续性肾脏替代治疗联合新活素治疗顽固性心力衰竭的效果分析

徐晓飞

doi:10.13898/j.cnki.issn.1000-2200.2017.05.014

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连续性肾脏替代治疗联合新活素治疗顽固性心力衰竭的效果分析

徐晓飞

文章导航 > 蚌埠医学院学报 > 2017, 42 > 5: (609-611,615)

引用本文:

Citation:

连续性肾脏替代治疗联合新活素治疗顽固性心力衰竭的效果分析

徐晓飞

安徽省滁州市第一人民医院心内科, 239000

作者简介: 徐晓飞(1983-),男,主治医师.

中图分类号: R541.61

Effect analysis of CRRT combined with natriuretic peptide in the treatment of refractory heart failure

XU Xiao-fei

Department of Cardiology, The First People's Hospital of Chuzhou, Chuzhou Anhui 239000, China
CLC number: R541.61

摘要: 目的：探讨连续性肾脏替代治疗（CRRT）联合新活素治疗顽固性心力衰竭的效果。方法：选取顽固性心力衰竭病人92例，根据病人是否应用CRRT分为观察组48例和对照组44例。对照组在常规治疗基础上加用新活素，观察组在常规治疗基础上联合应用新活素和CRRT。治疗7 d后观察2组疗效，以及治疗前后心功能指标变化及炎症因子变化情况。结果：观察组治疗总有效率为87.50%，明显高于对照组的54.55%（P<0.01）；2组病人治疗后左心室射血分数均较治疗前升高（P<0.01～P<0.05），氨基末端B型脑钠肽前体均较治疗前明显降低（P<0.01），且观察组左心室射血分数升高及氨基末端B型脑钠肽前体下降更为明显（P<0.01）；2组病人炎症因子高敏C反应蛋白、肿瘤坏死因子-α均较治疗前降低（P<0.05～P<0.01），且观察组降低更明显（P<0.01）；对照组2例出现低血压，观察组3例出现低血压。结论：CRRT联合新活素治疗顽固性心力衰竭的效果更佳，可明显改善顽固性心力衰竭病人心功能，减轻炎症反应。
- 心力衰竭 /
- 连续性肾脏替代治疗 /
- 新活素 /
- 心功能 /
- 炎症因子
Abstract: Objective: To investigate the effects of continuous renal replacement therapy(CRRT) combined with natriuretic peptide in the treatment of refractory heart failure.Methods: Ninety-two patients with refractory heart failure were divided into the observation group(48 cases) and control group(44 cases) according to the use of CRRT.The control group and observation group were treated with conventional method combined with natriuretic peptide,and conventional method combined with natriuretic peptide and CRRT.The curative effects in two groups were observed after 7 days of treatment,and the changes of cardiac function and inflammatory factor in two groups between before and after treatment were compared.Results: The total effective rate in observation group(87.50%) was higher than that in control group(54.55%)(P<0.01).Compared with before treatment,the levels of LEVF and amino-terminal B type brain natriuretic peptide precursor(NT-proBNP) in two groups increased,and decreased after treatment,respectively(P<0.05 to P<0.01),and the degrees of the LEVF increasing and NT-proBNP decreasing in observation group were more obvious(P<0.01).Compared with before treatment,the levels of hs-CRP and TNF-α in two groups decreased after treatment(P<0.05 to P<0.01),and the decreasing degree of those in observation group was more obvious(P<0.01).Two cases with hypotension in control group and 3 cases with hypotension in observation group were found.Conclusions: The effect of CRRT combined with natriuretic peptide in the treatment of refractory heart failure is good,which can obviously improve cardiac function,and reduce inflammation reactions of patients.
- heart failure /
- continuous renal replacement therapy /
- natriuretic peptide /
- cardiac function /
- inflammatory factor

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连续性肾脏替代治疗联合新活素治疗顽固性心力衰竭的效果分析

徐晓飞

作者简介: 徐晓飞(1983-),男,主治医师.

安徽省滁州市第一人民医院心内科, 239000

收稿日期: 2016-12-22

关键词:

摘要: 目的：探讨连续性肾脏替代治疗（CRRT）联合新活素治疗顽固性心力衰竭的效果。方法：选取顽固性心力衰竭病人92例，根据病人是否应用CRRT分为观察组48例和对照组44例。对照组在常规治疗基础上加用新活素，观察组在常规治疗基础上联合应用新活素和CRRT。治疗7 d后观察2组疗效，以及治疗前后心功能指标变化及炎症因子变化情况。结果：观察组治疗总有效率为87.50%，明显高于对照组的54.55%（P<0.01）；2组病人治疗后左心室射血分数均较治疗前升高（P<0.01～P<0.05），氨基末端B型脑钠肽前体均较治疗前明显降低（P<0.01），且观察组左心室射血分数升高及氨基末端B型脑钠肽前体下降更为明显（P<0.01）；2组病人炎症因子高敏C反应蛋白、肿瘤坏死因子-α均较治疗前降低（P<0.05～P<0.01），且观察组降低更明显（P<0.01）；对照组2例出现低血压，观察组3例出现低血压。结论：CRRT联合新活素治疗顽固性心力衰竭的效果更佳，可明显改善顽固性心力衰竭病人心功能，减轻炎症反应。

English Abstract

Effect analysis of CRRT combined with natriuretic peptide in the treatment of refractory heart failure

XU Xiao-fei

Department of Cardiology, The First People's Hospital of Chuzhou, Chuzhou Anhui 239000, China

Received Date: 2016-12-22

Abstract: Objective: To investigate the effects of continuous renal replacement therapy(CRRT) combined with natriuretic peptide in the treatment of refractory heart failure.Methods: Ninety-two patients with refractory heart failure were divided into the observation group(48 cases) and control group(44 cases) according to the use of CRRT.The control group and observation group were treated with conventional method combined with natriuretic peptide,and conventional method combined with natriuretic peptide and CRRT.The curative effects in two groups were observed after 7 days of treatment,and the changes of cardiac function and inflammatory factor in two groups between before and after treatment were compared.Results: The total effective rate in observation group(87.50%) was higher than that in control group(54.55%)(P<0.01).Compared with before treatment,the levels of LEVF and amino-terminal B type brain natriuretic peptide precursor(NT-proBNP) in two groups increased,and decreased after treatment,respectively(P<0.05 to P<0.01),and the degrees of the LEVF increasing and NT-proBNP decreasing in observation group were more obvious(P<0.01).Compared with before treatment,the levels of hs-CRP and TNF-α in two groups decreased after treatment(P<0.05 to P<0.01),and the decreasing degree of those in observation group was more obvious(P<0.01).Two cases with hypotension in control group and 3 cases with hypotension in observation group were found.Conclusions: The effect of CRRT combined with natriuretic peptide in the treatment of refractory heart failure is good,which can obviously improve cardiac function,and reduce inflammation reactions of patients.