脑神经胶质瘤病人脑脊液TSGF及HGF对新生血管生成相关因子的影响

李峰

doi:10.13898/j.cnki.issn.1000-2200.2017.06.019

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脑神经胶质瘤病人脑脊液TSGF及HGF对新生血管生成相关因子的影响

李峰

文章导航 > 蚌埠医学院学报 > 2017, 42 > 6: (758-760)

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脑神经胶质瘤病人脑脊液TSGF及HGF对新生血管生成相关因子的影响

李峰

铜川矿务局中心医院神经外科, 陕西铜川 727000

作者简介: 李峰(1978-),男,主治医师.

中图分类号: R739.41

Effect of tumor specific growth factor and hepatocyte growth factor in cerebrospinal fluid of glioma patients on the neovascularization factor

LI Feng

Department of Neurosurgery, Tongchuan Mining Central Hospital, Tongchuan Shaanxi 727000, China
CLC number: R739.41

摘要: 目的：探讨恶性肿瘤特异性生长因子（TSGF）及肝细胞生长因子（HGF）对脑神经胶质瘤进展的影响及与新生血管生成相关因子的关系。方法：选择87例胶质细胞瘤病人，WHO胶质细胞瘤分级（Ⅰ级29例，Ⅱ级26例，Ⅲ级21例，Ⅳ级11例，检测各级病人脑脊液TSGF及HGF、血管内皮生长因子（VEGF）、内皮生长因子（EGF）及促血管生成素1（Ang-1）。结果：Ⅱ级病人TSGF及HGF均较Ⅰ级明显升高（P<0.01），Ⅲ级病人TSGF及HGF均较Ⅰ级、Ⅱ级明显升高（P<0.01），Ⅳ级病人TSGF及HGF均较Ⅰ级、Ⅱ级、Ⅲ级明显升高（P<0.01）。Ⅱ级病人VEGF较Ⅰ级明显升高（P<0.01），Ⅲ级病人VEGF均较Ⅰ级、Ⅱ级明显升高（P<0.01），碱性成纤维细胞生长因子（bFGF）及Ang-1均较Ⅰ级明显升高（P<0.01），Ⅳ级病人VEGF均较Ⅰ级、Ⅱ级、Ⅲ级明显升高（P<0.01），bFGF及Ang-1均较Ⅰ级、Ⅱ级明显升高（P<0.01）。TSGF与VEGF、bFGF及Ang-1均呈正相关关系（P<0.05~P<0.01），HGF与VEGF亦呈正相关关系（P<0.01）。结论：脑脊液内TSGF及HGF水平升高是导致神经胶质瘤分级进展的重要因素，其过程与新生血管生成相关因子水平升高密切相关。
- 神经胶质瘤 /
- 恶性肿瘤特异性生长因子 /
- 肝细胞生长因子 /
- 新生血管
Abstract: Objective: To investigate the effects of the tumor specific growth factor(TSGF) and hepatocyte growth factor(HGF) on the progress of brain glioma,and relationship between TSGF,HGF and neovascularization factor. Methods: Eighty-seven glioma patients(including 29 cases of WHO grade Ⅰ,26 cases of WHO grade Ⅱ,21 cases of WHO grade Ⅲ and 11 cases of WHO grade Ⅳ) were investigated.The levels of TSGF,HGF,epidermal growth factor(EGF),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and angiopoietin 1(Ang-1) in cerebrospinal fluid of all patients were detected. Results: Compared with gradeⅠpatients,the levels of TSGF and HGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the levels of TSGF and HGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and gradeⅢ patients,the levels of TSGF and HGF in grade Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠpatients,the level of VEGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the level of VEGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠand Ⅱpatients,the levels of bFGF and Ang-1 in grade Ⅲ and Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and grade Ⅲ patients,the level of VEGF in grade Ⅳ patients significantly increased(P<0.01).The level of TSGF was positively correlated with the levels of VEGF,bFGF and Ang-1(P<0.05 to P<0.01),and the level of HGF was positively correlated with the level of VEGF(P<0.01). Conclusions: The increasing level of HGF and TSGF in cerebrospinal fluid is an important factor in glioma progress,which is closely related to the increasing of neovasculization factor.
- glioma /
- tumor specific growth factor /
- hepatocyte growth factor /
- neovasculization

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脑神经胶质瘤病人脑脊液TSGF及HGF对新生血管生成相关因子的影响

李峰

作者简介: 李峰(1978-),男,主治医师.

铜川矿务局中心医院神经外科, 陕西铜川 727000

收稿日期: 2015-09-11

关键词:

摘要: 目的：探讨恶性肿瘤特异性生长因子（TSGF）及肝细胞生长因子（HGF）对脑神经胶质瘤进展的影响及与新生血管生成相关因子的关系。方法：选择87例胶质细胞瘤病人，WHO胶质细胞瘤分级（Ⅰ级29例，Ⅱ级26例，Ⅲ级21例，Ⅳ级11例，检测各级病人脑脊液TSGF及HGF、血管内皮生长因子（VEGF）、内皮生长因子（EGF）及促血管生成素1（Ang-1）。结果：Ⅱ级病人TSGF及HGF均较Ⅰ级明显升高（P<0.01），Ⅲ级病人TSGF及HGF均较Ⅰ级、Ⅱ级明显升高（P<0.01），Ⅳ级病人TSGF及HGF均较Ⅰ级、Ⅱ级、Ⅲ级明显升高（P<0.01）。Ⅱ级病人VEGF较Ⅰ级明显升高（P<0.01），Ⅲ级病人VEGF均较Ⅰ级、Ⅱ级明显升高（P<0.01），碱性成纤维细胞生长因子（bFGF）及Ang-1均较Ⅰ级明显升高（P<0.01），Ⅳ级病人VEGF均较Ⅰ级、Ⅱ级、Ⅲ级明显升高（P<0.01），bFGF及Ang-1均较Ⅰ级、Ⅱ级明显升高（P<0.01）。TSGF与VEGF、bFGF及Ang-1均呈正相关关系（P<0.05~P<0.01），HGF与VEGF亦呈正相关关系（P<0.01）。结论：脑脊液内TSGF及HGF水平升高是导致神经胶质瘤分级进展的重要因素，其过程与新生血管生成相关因子水平升高密切相关。

English Abstract

Effect of tumor specific growth factor and hepatocyte growth factor in cerebrospinal fluid of glioma patients on the neovascularization factor

LI Feng

Department of Neurosurgery, Tongchuan Mining Central Hospital, Tongchuan Shaanxi 727000, China

Received Date: 2015-09-11

Abstract: Objective: To investigate the effects of the tumor specific growth factor(TSGF) and hepatocyte growth factor(HGF) on the progress of brain glioma,and relationship between TSGF,HGF and neovascularization factor. Methods: Eighty-seven glioma patients(including 29 cases of WHO grade Ⅰ,26 cases of WHO grade Ⅱ,21 cases of WHO grade Ⅲ and 11 cases of WHO grade Ⅳ) were investigated.The levels of TSGF,HGF,epidermal growth factor(EGF),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and angiopoietin 1(Ang-1) in cerebrospinal fluid of all patients were detected. Results: Compared with gradeⅠpatients,the levels of TSGF and HGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the levels of TSGF and HGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and gradeⅢ patients,the levels of TSGF and HGF in grade Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠpatients,the level of VEGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the level of VEGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠand Ⅱpatients,the levels of bFGF and Ang-1 in grade Ⅲ and Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and grade Ⅲ patients,the level of VEGF in grade Ⅳ patients significantly increased(P<0.01).The level of TSGF was positively correlated with the levels of VEGF,bFGF and Ang-1(P<0.05 to P<0.01),and the level of HGF was positively correlated with the level of VEGF(P<0.01). Conclusions: The increasing level of HGF and TSGF in cerebrospinal fluid is an important factor in glioma progress,which is closely related to the increasing of neovasculization factor.