改良养膜方治疗肾虚血瘀型薄型子宫内膜疗效评价
Assessment of efficacy of modified Yangmo Decoction in the treatment of kidney deficiency and blood stasis type thin endometrium
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摘要: 目的：探讨改良养膜方治疗肾虚血瘀型薄型子宫内膜病人的临床效果。方法：80例肾虚血瘀型薄型子宫内膜病人根据治疗方法不同分为观察组（n=40）和对照组（n=40）。对照组给予常规西药治疗，观察组在对照组基础上给予改良养膜方治疗。判定2组临床疗效，超声检查子宫内膜厚度和子宫基底区动脉血流动力学变化，观察卵泡发育情况，并统计2组妊娠率。结果：观察组临床总有效率为92.5%，明显高于对照组的75.0%（P<0.05）。2组治疗前子宫内膜厚度差异无统计学意义（P>0.05），治疗后观察组子宫内膜厚度显著大于对照组（P<0.01）。2组治疗前阻力指数（RI）、搏动指数（PI）差异均无统计学意义（P>0.05），治疗后观察组RI、PI低于对照组（P<0.01）。观察组治疗后首次监测卵泡卵泡数目、卵泡直径均高于对照组（P<0.05~P<0.01）；观察组和对照组总卵泡数分别为55个和49个，其中相应76.36%、57.14%的卵泡为≥18 mm的成熟卵泡，2组间差异有统计学意义（P<0.05）。观察组治疗后临床妊娠率、生化妊娠率为47.5%、22.5%，均显著高于对照组的25.0%、5.0%（P<0.05）。结论：改良养膜方治疗肾虚血瘀型薄型子宫内膜的临床疗效显著，对改善病人子宫内膜厚度、卵泡发育及提高妊娠率有重要作用。Abstract: Objective: To investigate the clinical effects of the modified Yangmo Decoction in the treatment of kidney deficiency and blood stasis type thin endometrium. Methods: Eighty patients with kidney deficiency and blood stasis type thin endometrium were divided into the observation group(n=40) and control group(n=40) according to the different treatment methods.The control group was treated with routine western medicine,and the observation group was treated with the modified Yangmo Decoction based on control group.The clinical efficacy of two groups was evaluated,and the endometrial thickness and hemodynamic changes of uterine basilar artery were examined by ultrasonography.The follicular development was observed,and the pregnancy rates of two groups were analyzed. Results: The total effective rate of the observation group(92.5%) was significantly higher than that of control group(75.00%)(P<0.05).There was no statistical significance in endometrial thickness between two groups before treatment(P>0.05),and the endometrial thickness in observation group was significantly thicker than that in control group after treatment(P<0.05).There were no statistical significances in the resistance index(RI) and pulsatility index(PI) between two groups before treatment(P>0.05).After treatment,the RI and PI in observation group were significantly lower than those in control group(P<0.05).After treatment,the initial number of follicles and follicular diameter in observation group were significantly higher than those in control group(P<0.05).The total number of follicles in observation group and control group was 55 and 49,respectively,and the 76.36% and 57.14% of follicles were mature follicles(diameter ≥ 18 mm)(P<0.05),and the difference of which was statistically significant(P<0.05).After treatment,the clinical pregnancy rate and biochemical pregnancy rate in observation group(47.50% and 22.50%) were significantly higher than those in control group(25.00% and 5.00%),respectively(P<0.05). Conclusions: Modified Yangmo Decoction is significantly effective in the treatment of kidney deficiency and blood stasis type thin endometrium,which plays an important role in improving the endometrial thickness,follicular development and pregnancy rate.
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Key words:
- endometrium /
- Yangmo Decoction /
- modified /
- kidney deficiency and blood stasis /
- pregnancy
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[1] RIAD ON,HAK AA.Assessment of endometrial receptivity using Doppler ultrasonography in infertile women undergoing intrauterine insemination[J].Uynecol Endocrino1,2014,30(1):70. [2] 黎雪茹,王中海.薄型子宫内膜的研究进展[J/CD].中华妇幼临床医学杂志(电子版),2015,11(1):109. [3] 宋婧,李环,张巍颖,等.低频电刺激对雌激素治疗效果欠佳薄型子宫内膜病人的临床疗效分析[J].新医学,2016,47(9):618. [4] 李群.养膜汤对不孕症薄型子宫内膜的影响[J].河北中医,2016,38(3):378. [5] 乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:415. [6] 欧阳惠卿.中医妇科学[M].北京:人民卫生出版社,2004:224. [7] 郑莜萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:249. [8] 哈灵侠,袁莹莹,裴利国,等.粒细胞集落刺激因子宫腔灌注在改善薄型子宫内膜中的应用价值[J].中国妇幼保健,2015,30(1):82. [9] WONTER E,WANG J,DAVIES MJ, et al.Early pregnancy loss following assisted reproductive technology treatment[J].Hum Reprod,2002,17(12):3220. [10] 孙琴,李鸿儒,邵一丹,等.他莫昔芬用于薄型子宫内膜患者冻融胚胎移植疗效观察的随机对照临床研究[J].医学研究生学报,2017,30(1):52. [11] SCHILD,KNOBLOCH C,DORN C, et al.Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow,endometrial thickness,endometrial volume,and uterine artery blood flow[J].Fertil Steril,2001,75(2):361. [12] 余小英,马科,胡卫华,等.复方玄驹胶囊联合小剂量雌激素治疗肾阳虚型薄型子宫内膜不孕症患者的临床疗效观察[J].生殖与避孕,2015,35(9):612. [13] 周茂溪,冯雪花,李玉,等.血流方对肾虚血瘀型冻融胚胎移植患者子宫内容受性影响[J].辽宁中医药大学学报,2013,15(10):183. [14] 薛惠英,左阳花,冯播,等.U8仿生物电刺激治疗薄型子宫内膜不孕症的临床研究[J].重庆医学,2013,42(21):2505. [15] 武巧珍,徐珺,诸葛飞,等.两种雌激素对去卵巢大鼠子宫内膜的影响[J].安徽医药,2014,18(11):2054. [16] 张秦溪,杜伯涛,苗瑞超,等.经阴道补充雌激素对促排卵期薄型子宫内膜的影响[J].生殖与避孕,2014,34(4):287. [17] 李楠,陈梅,李翡,等.补肾中药复方对缺血性损伤大鼠薄型子宫内膜厚度及组织病理学的影响[J].陕西中医,2016,37(10):1425. [18] 黄爱清,张倩,张树怡.滋肾活血汤治疗子宫内膜薄致月经过少肾虚血瘀证的疗效观察[J].湖南中医药大学学报,2014,34(8):44. [19] 江媚,刘雁峰,黄羚.子宫内膜容受性低中医证型特点初探[J].中华中医药杂志,2015,30(11):3836. -
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