老年男性病人胰岛素样生长因子-1水平与生活质量及营养状态的相关性分析
The relationship of the insulin-like growth factor-1 levels with quality of life and nutritional status in elderly male patients
-
摘要: 目的：探讨老年男性病人胰岛素样生长因子-1（IGF-1）水平与其生活质量及营养状态的相关性。方法：收集60岁以上老年男性病人50例，分为老年组（60~79岁）20例和高龄组（≥ 80岁组）30例。2组分别测定血清IGF-1水平，同时采用生活质量健康状况问卷（SF-36）和微量营养评分（MNA-SF）、老年营养风险指数（GNRI）进行生活质量及营养状评价。结果：高龄组病人的血清IGF-1水平为（112.1±46.4）μg/L，低于老年组的（82.8±42.1）μg/L（P<0.05）。除躯体疼痛外，高龄组病人SF-36量表其他7个纬度评分均明显低于老年组（P<0.01）；高龄组MNA-SF评分及GNRI亦均明显低于老年组（P<0.01）。相关分析显示，病人IGF-1水平与年龄呈负相关关系（P<0.05）。校正年龄后，病人血清IGF-1水平与SF-36健康量表中生理机能、生理职能、躯体疼痛、活力、总体健康、精神健康、情感职能及营养评分均呈正相关关系（P<0.01），而与社会功能无显著相关性（P>0.05）；IGF-1水平与MNA-SF评分及GNRI亦均呈正相关关系（P<0.01和P<0.05）。结论：老年男性病人血清IGF-1水平较低，且与年龄呈负相关关系；血清IGF-1水平的降低影响老年病人生活质量及营养状态。
-
关键词:
- 老年 /
- 男性 /
- 胰岛素样生长因子-1 /
- 生活质量 /
- 营养
Abstract: Objective:To discuss the effects of the changes of insulin-like growth factor-1 (IGF-1) levels on the quality of life and nutritional status in elderly male patients.Methods:A total of 50 elderly male patients(60-95 years old) were divided into 2 groups according to age:the elderly patient group(60-79 years old,n=20) and the older patient group(over 80 years old,n=30).Levels of IGF-1 were detected.The SF-36 questionnaire,micro-nutrient assessment table (MNA-SF),and geriatric nutritional risk index(GNRI) were conducted to evaluate the quality of life and nutritional status.Results:The IGF-1 level was higher in the older patient group[(112.1±46.4) μg/L] than that in the elderly patient group[(82.8±42.1) μg/L](P<0.05).In addition to body pain score,scores of other 7 dimensions of SF-36 scale in the older patient group were significantly lower than those in the elderly patient group(P<0.01).Scores of MNA-SF and GNRI in the older patient group were also significantly lower than those in the elderly patient group(P<0.01).Correlation analysis showed that age had a negative correlation with IGF-1 level in elderly male patients(P<0.05).After adjusting the age,IGF-1 level was positively correlated with physical function,role of physical activity,body pain,general health,vitality,mental health,emotional function and nutritional status in SF-36 scale(P<0.01),and had no obvious correlation with social function(P>0.05).IGF-1 level was also positively correlated with scores of MNA-SF and GNRI(P<0.01 and P<0.05).Conclusions:The level of serum IGF-1 in elderly male patients was low,and was negatively correlated with age,which can seriously affect the quality of life and nutritional status in elderly patients.-
Key words:
- elderly /
- male /
- insulin-like growth factor-1 /
- quality of life evaluation /
- nutrition assessment
-
[1] 吴曼,王卫东.中老年男性血清生长激素水平与年龄的关系及对生活质量的影响[J].中国临床保健杂志.2013,10(5):462. [2] COLAO A,SPIEZIA S,DE SOMMA C,et al.Circulating insulin-like growth factor-1 levels are correlated with the atherosclerotic profile in healthy subjects independently of age[J].J Endocrinol Invest,2005,28:440. [3] LOCATELLI V,BIANCHI VE.Effect of GH/IGF-1 on BoneMetabolism and Osteoporsosis[J].Int J Endocrinol,2014,2014:235060. [4] KELLY A,RUSH J,SHAFONSKY E,et al.Detecting short-term change and variation in health-related quality of life:within-and between-person factor structure of the SF-36 health survey.[J].Health Qual Life Outcomes,2015,13(1):199. [5] KAISER JM,BAUER JM,RAMSCH C,et al.MNA International Group.Validation of the Mini Nutritional Assessment short-from(MNA-SF):a practical tool for utriaication of nutritional status[J].J Nutr Health Aging,2009,13:782. [6] BOUILANNE O,MORINEAU G,DUPONT C,et al.Geriatric utria-tional risk index:a new index for evaluating at-risk elderly medical patients[J].Am J Clin Nutr,2005,82:777. [7] FRUTOS MG,CACICEDO L,MENDEZ CF,et al.Pituitary alterations involved in the decline of growth hormone gene expression in the pituitary of aging rats[J].J Gerontol A Biol Sci Med Sci,2007,62(6):585. [8] MULLER AP,FERNANDEZ AM,HAAS C,et al.Reduced brain insulin-like growth factor I function during aging[J].Mol Cell Neurosci,2012,49:9. [9] ROSEN CJ,CONOVER C.GH/IGF-1 axis in aging:a summary of a NIA-sponssored symposium[J].J Clin Endocrinol Metab,1997,82:3919. [10] 袁鹰,付正菊,张敏,等.肥胖病人血清游离胰岛素样生长因子I及其结合蛋白水平与代谢因素的关系[J].中华内分泌代谢杂2003,19(3):184. [11] YAMADA M,NISHIGUCHI S,FUKUTANI N,et al.Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults:The INE (Intervention by Nutrition and Exercise) Study[J].J Am Med Dir Assoc,2015,16(8):654. [12] APPELMAN-DIJKSTRA NM,CLAESSEN KM,ROELFSEMA F,et al.Long-term effects of recombinant human GH replacement in adults with GH deficiency:a systematic review[J].Eur J Endocrinol,2013,169(1):R1. [13] GILET H,CHACHUAT A,VIALA-DANTEN M,et al.Application of the disease-specific Quality of Life Assessment of Growth Hormone Deficiency in Adults question-naire in a general population:results from a French panel study[J].Value In Health,2010,13(4):495. [14] 黄志红,桂影,张国增,等.老年病人围手术期中生长激素的应用及对预后的影响[J].中国老年学杂志,2014,34(5):2346. [15] SHIMATSU A,IWAMOTO N,TANAKA T,et al.Possible predictors for QOL improvement following GH replacement therapy in adult GHD[J].Endocr J,2015,62(8):749. -
点击查看大图
计量
- 文章访问数: 3760
- HTML全文浏览量: 434
- PDF下载量: 64
- 被引次数: 0
下载:
