半夏泻心汤对慢性萎缩性胃炎癌前病变病人胃癌相关基因的影响
Effect of Banxia Xiexin decoction on the related genes of gastric cancer in chronic atrophic gastritis patients with precancerous lesions
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摘要: 目的：探讨半夏泻心汤对慢性萎缩性胃炎癌前病变病人胃癌相关基因的影响。方法：收集慢性萎缩性胃炎癌前病变病人96例，随机分为2组，对照组病人给予胃复春片，观察组病人则加服半夏泻心汤，比较2组病人临床症状积分、总体治疗效果、胃癌相关基因积分与表达。结果：治疗后，观察组病人临床症状总积分（8.96±4.37）分，明显低于对照组的（13.68±4.96）分（P<0.01），观察组Cyclin D1积分（1.30±0.48）分，低于对照组的（1.83±0.51）分（P<0.01），观察组PTEN积分（2.96±0.50）分，高于对照组的（2.33±0.42）分（P<0.01），观察组总有效率78.00%，明显高于对照组的54.35%（P<0.05）。结论：半夏泻心汤对慢性萎缩性胃炎癌前病变病人胃癌相关基因的影响显著，具有借鉴意义。Abstract: Objective:To investigate the effects of Banxia Xiexin decoction on the related genes of gastric cancer in patients with chronic atrophic gastritis.Methods:Ninety-six chronic atrophic gastritis patients with precancerous lesions were randomly divided into the control group group and observation group.The control group group and observation group were treated with Weifuchun tablets and Banxia Xiexin decoction,respectively.The clinical symptom score,overall therapeutic effect,distribution and expression of related gene of gastric cancer between two groups were compared.Results:After treatment,the clinical symptom score in observation group(8.96±4.37) was significantly lower than that in control group(13.68±4.96)(P<0.01),the Cyclin D1 score in observation group(1.30±0.48)was significantly lower than that in control group(1.83±0.51)(P<0.01),the PTEN score in observation group(2.96±0.50) was significantly higher than that in control group(2.33±0.42)(P<0.01),and the total effect rate in observation group(78%) was significantly higher than that in control group(54.35%)(P<0.05).Conclusions:The effect of Banxia Xiexin decoction on the related genes of gastric cancer in precancerous lesions patients with chronic atrophic gastritis is significant,which has an important significance.
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