动态增强MRI定量参数及表观扩散系数值与宫颈癌临床病理特征的相关性分析
Correlation analysis of dynamic contrast-enhanced MRI quantitative parameters and apparent diffusion coefficient values with clinicopathological features in cervical cancer patients
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摘要: 目的:探讨动态增强MRI(DCE-MRI)定量参数及表观扩散系数(ADC)值与宫颈癌病人临床病理特征的相关性。方法:选取宫颈癌病人52例作为观察组,另选同时期住院宫颈正常女性病人25例作为对照组,对2组女性行DCE-MRI,比较2组DCE-MRI定量参数容量转移常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve)、ADC值,观察不同病灶各扫描参数的变化情况,采用Spearman分析定量参数及ADC值与宫颈癌病人临床病理特征的相关性。结果:对照组ADC值高于观察组,观察组Ktrans、Kep、Ve值高于对照组(P<0.01);宫颈鳞癌ADC值低于宫颈腺癌(P<0.05),Ktrans值高于宫颈腺癌(P<0.01);在有无淋巴结转移、脉管浸润及肿瘤最大径扫描参数比较中,ADC、Ktrans、Kep、Ve值差异无统计学意义(P>0.05);不同分化程度宫颈鳞癌病人ADC值、Ktrans、Kep值差异均有统计学意义(P<0.05~P<0.01);经Spearman相关性分析,鳞癌分化程度、临床分期与ADC值呈负相关关系,与Ktrans、Kep呈正相关关系(P<0.01),鳞癌分化程度与Ve值无明显相关关系(P>0.05),临床分期与Ve值呈正相关关系(P<0.01)。结论:可根据宫颈癌病人DCE-MRI定量参数及ADC值对病灶分化程度、临床分期进行有效评估。
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关键词:
- 宫颈肿瘤 /
- DCE-MRI定量参数 /
- ADC值 /
- 临床病理特征
Abstract: Objective:To investigate the correlation of the dynamic contrast-enhanced MRI(DCE-MRI) quantitative parameters and apparent diffusion coefficient(ADC) values with clinicopathological features in cervical cancer patients.Methods:Fifty-two patients with cervical cancer and 25 inpatients without cervix disease were divided into the observation group and control group,respectively.The Ktrans,Kep,Ve and ADC values of DCE-MRI quantification parameters between two groups were compared.The change of scanning parameters in different lesions in two groups were observed.The correlation between quantitative parameters,ADC values,and clinicopathological features of cervical cancer patients were analyzed using the Spearman correlation analysis.Results:The ADC value in control group was higher than that in observation group,and the Ktrans,Kep and Ve values in control group were lower than those in observation group(P<0.01).The ADC value and Ktrans value in cervical squamous cell carcinoma were lower and higher than that in cervical adenocarcinoma,respectively(P<0.01).There was no statistical significance in the Ktrans,Kep,Ve and ADC values among the different lymph node metastasis,lymphovascular invasion,and tumor size(P>0.05).The differences of the Ktrans,Kep and ADC values in different differentiation degree cervical squamous cell carcinoma patients were statistically significant(P<0.05 to P<0.01).The results of Spearman correlation analysis showed that the differentiation degree and clinical stage of squamous cell carcinoma were negatively correlated with ADC values,the differentiation degree of squamous cell carcinoma was not correlated with the Ve value(P>0.05),and the clinical stage of squamous cell carcinoma were positively correlated with Ve value(P<0.01).Conclusions:The differentiation degree and clinical stage can be effectively evaluated according to the quantitative parameters of DCE-MRI and ADC values in cervical cancer patients. -
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