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nNOS及其耦联蛋白:重大神经精神疾病的新治疗靶标

朱东亚

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nNOS及其耦联蛋白:重大神经精神疾病的新治疗靶标

    作者简介: 朱东亚(1956-),男,博士研究生导师,教授.
  • 中图分类号: R74

  • [1] ZHOU L,ZHU DY.Neuronal nitric oxide synthase:structure,subcellular localization,regulation,and clinical implications[J].Nitric Oxide,2009,20(4):223.
    [2] LUO CX,ZHU DY.Research progress on neurobiology of neuronal nitric oxide synthase[J].Neurosci Bull,2011,27(1):23.
    [3] HU Y,ZHU DY.Hippocampus and nitric oxide[J].Vitam Horm,2014(96):127.
    [4] ZHU DY,DENG Q,YAO HH,et al.Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice[J].Life Sci,2002,71(17):1985.
    [5] JIANG J,WANG W,SUN YJ,et al.Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage[J].Eur J Pharmacol,2007,561(1/3):54.
    [6] ZHU DY,LIU SH,SUN HS,et al.Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus[J].J Neurosci,2003,23(1):223.
    [7] LIU S,WANG J,ZHU D,et al.Generation of functional inhibitory neurons in the adult rat hippocampus[J].J Neurosci,2003,23(3):732.
    [8] LUO CX,ZHU XJ,ZHANG AX,et al.Blockade of L-type voltage-gated Ca channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse[J].J Neurochem,2005,94(4):1077.
    [9] HUANG Z,HUANG PL,PANAHIAN N,et al.Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase[J].Science,1994,265(5180):1883.
    [10] PACKER MA,STASIV Y,BENRAISS A,et al.Nitric oxide negatively regulates mammalian adult neurogenesis[J].Proc Natl Acad Sci USA,2003,100(16):9566.
    [11] MORENO-LO'PEZ B,ROMERO-GRIMALDI C,NOVAL JA,et al.Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb[J].J Neurosci,2004,24(1):85.
    [12] ZHU XJ,HUA Y,JIANG J,et al.Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation[J].Neuroscience,2006,141(2):827.
    [13] LUO CX,ZHU XJ,ZHOU QG,et al.Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression[J].J Neurochem,2007,103(5):1872.
    [14] ZHU DY,LAU L,LIU SH,et al.Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus[J].Proc Natl Acad Sci USA,2004,101(25):9453.
    [15] LUO CX,JIANG J,ZHOU QG,et al.Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke[J].J Neurosci Res,2007,85(8):1637.
    [16] GEORGE PM,STEINBERG GK.Novel stroke therapeutics:unraveling stroke pathophysiology and its impact on clinical treatments[J].Neuron,2015,87(2):297.
    [17] LIU S,LAU L,WEI J,et al.Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemia[J].Neuron,2004,43(1):43.
    [18] PENG PL,ZHONG X,TU W,et al.ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia[J].Neuron,2006,49(5):719.
    [19] HU M,SUN YJ,ZHOU QG,et al.Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors[J].J Neurochem,2008,106(4):1900.
    [20] HU M,SUN YJ,ZHOU QG,et al.Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis[J].Eur J Pharmacol,2009,622(1-3):37.
    [21] AARTS M,LIU Y,LIU L,et al.Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions[J].Science,2002,298(5594):846.
    [22] ZHOU L,LI F,XU HB,et al.Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95[J].Nat Med,2010,16(12):1439.
    [23] LAI TW,WANG YT.Fashioning drugs for stroke[J].Nat Med,2010,16(12):1376.
    [24] JONES N.Disruption of the nNOS-PSD-95 complex is neuroprotective in models of cerebral ischemia[J].Nat Rev Neurol,2011,7(2):61.
    [25] DOUCET MV,LEVINE H,DEV KK,et al.Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice[J].Neuropsychopharmacology,2013,38(8):1575.
    [26] LEE WH,XU Z,ASHPOLE NM,et al.Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics[J].Neuropharmacology,2015,97:464.
    [27] DEYAMA S,SUGANO Y,MORI S,et al.Activation of the NMDA receptor-neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain[J].Neuropharmacology,2017,118:59.
    [28] CAREY LM,LEE WH,GUTIERREZ T,et al.Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats[J].Neuroscience,2017,349:303.
    [29] LUO CX,JIN X,CAO CC,et al.Bidirectional regulation of neurogenesis by neuronal nitric oxide synthase derived from neurons and neural stem cells[J].Stem Cells,2010,28(11):2041.
    [30] LUO CX,LIN YH,QIAN XD,et al.Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke[J].J Neurosci,2014,34(40):13535.
    [31] WANG DL,QIAN XD,LIN YH,et al.ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke[J].J Neurosci Res,2017,95(12):2409.
    [32] ZHOU HH,TANG Y,ZHANG XY,et al.Delayed administration of Tat-HA-NR2B9c promotes recovery after stroke in rats[J].Stroke,2015,46(5):1352.
    [33] LIN YH,DONG J,TANG Y,et al.Opening a new time window for treatment of stroke by targeting HDAC2[J].J Neurosci,2017,37(28):6712.
    [34] TANG Y,LIN YH,NI HY,et al.Inhibiting histone deacetylase 2(HDAC2) promotes functional recovery from stroke[J].J Am Heart Assoc,2017,6(10):e007236.
    [35] CLARKSON AN,HUANG BS,MACISAAC SE,et al.Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke[J].Nature,2010,468(7321):305.
    [36] LIN YH,LIANG HY,XU K,et al.Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice through reducing excessive tonic GABA release from reactive astrocytes[J].J Pathol,2018,244(2):176.
    [37] LEDERBOGEN F,KIRSCH P,HADDAD L,et al.City living and urban upbringing affect neural social stress processing in humans[J].Nature,2011,474(7352):498.
    [38] ZHOU QG,HU Y,HUA Y,et al.Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis[J].J Neurochem,2007,103(5):1843.
    [39] HUA Y,HUANG XY,ZHOU L,et al.DETA/NONOate,a nitric oxide donor,produces antidepressant effects by promoting hippocampal neurogenesis[J].Psychopharmacology,2008,200(2):231.
    [40] LI WL,CAI HH,WANG B,et al.Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke[J].J Neurosci Res,2009,87(1):112.
    [41] ZHOU QG,ZHU LJ,CHEN C,et al.Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor[J].J Neurosci,2011,31(21):7579.
    [42] HU Y,WU DL,LUO CX,et al.Hippocampal nitric oxide contributes to sex difference in affective behaviors[J].Proc Natl Acad Sci USA,2012,109(35):14224.
    [43] VOGEL G.Neuroscience.Depression drugs' powers may rest on new neurons[J].Science,2003,301(5634):757.
    [44] ZHOU QG,HU Y,WU DL,et al.Hippocampal telomerase is involved in the modulation of depressive behaviors[J].J Neurosci,2011,31(34):12258.
    [45] ZHOU QG,WU HY,ZHOU H,et al.Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice[J].Transl Psychiatry,2016,6(6):e836.
    [46] ZHOU QG,LIU MY,LEE HW,et al.Hippocampal TERT regulates spatial memory formation through modulation of neural development[J].Stem Cell Reports,2017,9(2):543.
    [47] LIU MY,YIN CY,ZHU LJ,et al.Sucrose preference test for measurement of stress-induced anhedonia in mice[J].Nat Protoc,2018,13(7):1686.
    [48] ZHANG J,HUANG XY,YE ML,et al.Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A-receptor in modulating anxiety-related behaviors[J].J Neurosci,2010,30(7):2433.
    [49] NELSON RJ,DEMAS GE,HUANG PL,et al.Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase[J].Nature,1995,378(6555):383.
    [50] ZHANG J,CAI CY,WU HY,et al.CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors[J].Sci Rep,2016(6):29551.
    [51] ZHU LJ,LI TY,LUO CX,et al.CAPON-nNOS coupling can serve as a target for developing new anxiolytics[J].Nat Med,2014,20(9):1050.
    [52] ZHU LJ,NI HY,CHEN R,et al.Hippocampal NF-κB accounts for stress-induced anxiety behaviors via enhancing nNOS-CAPON-Dexras1 coupling[J].J Neurochem,2018,doi:10.1111/jnc.14478.
    [53] ZHANG Y,ZHU Z,LIANG HY,et al.nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity,especially in the early stages[J].Aging Cell,2018,17(3):e12754.
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  • 收稿日期:  2018-08-01

nNOS及其耦联蛋白:重大神经精神疾病的新治疗靶标

    作者简介: 朱东亚(1956-),男,博士研究生导师,教授.
  • 南京医科大学 干细胞与神经再生研究所, 江苏 南京 210029
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