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近年来,急性心肌梗死(AMI)已成为严重威胁人类健康的慢性疾病之一,其发病率逐年上升。经皮冠状动脉介入治疗(PCI)作为AMI的重要治疗手段,对改善急性或持续性冠状动脉缺血缺氧引起的心肌缺血具有积极意义[1-2]。血压调节受靶器官功能状态和自主功能影响。PCI可以影响病人自主神经功能,进而影响PCI术后血压状态。目前,研究发现PCI术前及术后的血压变化波动较大且与主要不良心脑血管事件(MACCE)及支架再狭窄紧密联系[3-5]。迄今为止,关于PCI对血压影响的潜在机制研究很少。
维生素D的主要生理作用一直被认为是调节机体钙和磷的平衡和骨的矿化。维生素D受体(VDR)存在于大多数组织中,包括血管平滑肌、内皮细胞和心肌细胞。维生素D的活性形式是25-羟维生素D[(25(OH)D],可抑制肾素分泌,血管平滑肌和心肌细胞增殖,并调节细胞生长。25(OH)D在动脉粥样硬化、动脉钙化、心肌肥厚、血栓形成的发病机制中已经明确[6-7]。此外,25(OH)D与PCI术后MACCE发生具有紧密联系[8-9]。因此,25(OH)D可能在PCI术前及术后血压调节上具有潜在意义。本研究通过收集入院时AMI病人25(OH)D水平并观察PCI术前及术后24 h动态血压变化趋势,探讨25(OH)D水平与PCI术前及术后24 h动态血压之间的联系。现作报道。
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80例病人中,25(OH) D正常26例,不足21例,缺乏33例。3组病人WBC、CRP差异均有统计学意义(P < 0.05),WBC水平为缺乏组高于其余2组(P < 0.05),CRP水平为正常组低于其他2组(P < 0.05);其余各指标在3组之间差异均无统计学意义(P>0.05)(见表 1)。
分组 n 年龄 男性 BMI 血脂异常 糖尿病 肾病 吸烟 入院时治疗药物 生化指标 ACEI ARB β受体阻断剂 硝酸酯类 他汀类药物 CCB 利尿剂 氯吡格雷 Glu/(mg/dL) Cre/(mg/dL) LDL-C/(mg/dL) HDL-C/(mg/dL) TG/(mg/dL) TC/(mg/dL) WBC/(×109) Hb/(g/dL) CRP/(mg/L) 肌钙蛋白1/(nh/mL) CK-MB/(U/L) 缺乏 33 67.58±10.87 21 27.55±4.38 19 10 6 11 13 6 16 10 18 6 10 8 122.45±56.47 0.84±0.52 97.85±32.85 38.58±8.67 148.55±45.68 169.85±52.28 8.89±2.28 12.89±1.85 1.47±0.66 4.86±21.52 27.58±47.85 不足 21 64.22±11.58 18 26.75±4.51 15 9 5 12 9 5 12 7 14 5 7 6 119.78±51.47 0.83±0.52 91.52±39.84 39.58±8.74 138.74±52.84 156.88±44.85 7.38±2.27* 13.25±1.74 1.35±0.53 4.56±20.87 22.87±49.68 正常 26 63.88±12.47 20 27.88±4.76 18 11 7 12 11 6 15 8 16 6 9 7 120.25±50.68 0.82±0.52 86.88±36.58 40.25±9.85 137.84±50.69 154.85±41.48 7.33±2.11△ 13.54±1.71 1.06±0.49△# 4.54±19.85 23.84±51.22 F — 0.91 3.43* 0.37 1.39* 1.24* 0.67* 3.05* 0.08* 0.32* 0.63* 0.06* 1.38* 0.25* 0.13* 0.13* 0.02 0.01 0.69 0.25 0.43 0.88 4.64 0.99 3.77 0.00 0.07 P — >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 <0.05 >0.05 <0.05 >0.05 >0.05 MS组内 — 134.422 — 20.612 — — — — — — — — — — — — 2 847.251 0.270 1 295.180 82.581 2 426.642 2 216.981 4.944 3.158 0.332 433.523 2 444.379 *示χ2值;q检验:与缺乏组比较△P < 0.05;与不足组比较#P < 0.05 表 1 不同25(OH)D组一般资料比较
($ \overline{x}\pm s$) -
80例病人,10项指标中4项(dSBP、24hSBPV、dSBPV和dDBPV)在术后1周较入院有所降低(P < 0.05~P < 0.01),术后4周继续降低(P < 0.01);其余6项指标在术后4周较入院时均有不同程度降低(P < 0.05~P < 0.01)(见表 2)。
分组 24hSBP/mmHg 24hDBP/mmHg dSBP/mmHg dDBP/mmHg nSBP/mmHg nDBP/mmHg 24hSBPV 24hDBPV dSBPV dDBPV 入院时 137.40±9.89 83.29±8.52 141.45±9.54 84.33±8.22 133.46±8.51 80.54±8.04 16.43±2.16 12.43±1.98 15.22±2.05 11.52±2.11 术后1周 135.34±10.02 83.35±8.43 137.38±9.45** 84.66±8.12 132.62±8.45 81.38±8.08 15.42±1.99** 12.40±2.01 14.49±1.89* 10.85±2.02* 术后4周 130.94±10.24**△△ 80.32±8.24* 133.55±10.02**△ 80.81±8.07**△△ 123.84±8.39**△△ 77.53±7.96*△△ 12.14±2.08**△△ 11.23±2.05**△△ 12.42±2.24**△△ 10.40±2.04** F 8.62 3.40 13.34 5.50 31.81 5.09 93.21 9.24 39.58 6.01 P < 0.01 < 0.05 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 MS组内 101.023 70.518 93.572 66.209 71.405 64.430 4.317 4.054 4.264 4.231 q检验:与入院时比较*P < 0.05,**P < 0.01;与术后1周时比较△P < 0.05,△△P < 0.01 表 2 入组病人24 h动态血压变化情况
(ni=80;$ \overline{x}\pm s$) -
组内比较显示,3组病人的24hDBP、dSBP、dDBP和nDBP 4个指标在入院时、术后1周、术后4周的24 h动态血压差异均无统计学意义(P>0.05),正常组除上述4个指标外24hSBP在3个时间点差异也无统计学意义(P>0.05),3组病人的其余各指标在3个时间点的24 h动态血压差异均有统计学意义(P<0.05~P < 0.01);组间比较显示,25(OH) D缺乏组病人各时间点的24 h动态血压各指标均高于25(OH) D正常组病人(P < 0.05)(见表 3)。
分组 入院时 术后1周 术后4周 F P MS组内 缺乏(n=33) 24hSBP/mmHg 141.44±9.38 139.71±10.54 133.76±8.54**△ 5.91 <0.01 90.670 24hDBP/mmHg 85.79±8.34 87.22±8.24 84.48±8.11 0.91 >0.05 67.742 dSBP/mmHg 142.55±10.23 141.49±9.84 138.71±9.30 1.35 >0.05 95.990 dDBP/mmHg 88.86±8.54 88.84±8.34 85.11±7.68 2.29 >0.05 67.157 nSBP/mmHg 135.64±9.64 134.85±8.33 127.63±9.85**△△ 7.44 <0.01 86.447 nDBP/mmHg 83.64±7.21 84.22±8.17 80.34±7.26 2.53 >0.05 57.147 24hSBPV 17.61±3.37 16.64±2.67 13.15±2.64**△△ 21.40 <0.01 8.485 24hDBPV 13.95±1.27 13.84±1.12 12.17±2.05**△△ 13.93 < 0.01 2.357 dSBPV 16.67±3.38 15.27±3.25 13.84±2.54** 6.97 < 0.01 9.480 dDBPV 12.67±1.45 11.57±1.41** 10.79±2.07** 10.55 < 0.01 2.792 不足(n=21) 24hSBP/mmHg 139.55±10.51 135.84±11.24 131.84±8.77* 2.99 >0.05 104.570 24hDBP/mmHg 82.48±8.51 83.14±7.95 80.54±8.33 0.56 >0.05 68.337 dSBP/mmHg 140.67±9.84 139.57±10.31 131.64±9.54 2.21 >0.05 90.044 dDBP/mmHg 83.84±9.67 84.79±8.64 84.51±7.71 0.07 >0.05 75.868 nSBP/mmHg 134.78±8.94 133.88±9.86 125.61±10.05*△△ 5.79 < 0.01 92.715 nDBP/mmHg 79.86±6.11 80.28±8.28 78.54±7.51 0.32 >0.05 54.097 24hSBPV 16.58±3.41 15.44±2.58 12.61±2.53**△△ 10.66 < 0.01 8.229 24hDBPV 12.38±1.29 12.94±1.21 11.08±2.21*△△ 7.16 <0.01 2.671 dSBPV 15.47±3.22 15.29±3.14 12.64±2.48**△△ 6.00 < 0.01 8.793 dDBPV 11.27±1.33 11.17±1.31 10.84±2.17 0.39 >0.05 2.731 正常(n=26) 24hSBP/mmHg 130.54±9.84 129.38±11.05 126.64±8.68 1.06 >0.05 98.090 24hDBP/mmHg 79.54±8.67# 78.62±8.39# 77.94±8.28# 0.23 >0.05 71.373 dSBP/mmHg 131.51±10.94# 130.38±9.79# 128.55±9.63# 0.56 >0.05 102.755 dDBP/mmHg 78.98±8.47# 79.24±8.44# 78.51±7.52# 0.05 >0.05 66.508 nSBP/mmHg 129.64±9.94# 128.76±8.68# 117.61±10.25**△△# 12.56 < 0.01 93.070 nDBP/mmHg 77.15±7.17# 78.65±8.64# 73.14±8.02△# 3.32 < 0.05 63.460 24hSBPV 14.82±3.18# 13.84±2.62# 10.47±2.52**△△# 17.41 < 0.01 7.776 24hDBPV 10.54±1.07# 10.14±1.08# 10.17±2.11# 0.57 >0.05 2.255 dSBPV 13.17±3.12# 12.84±3.65# 10.44±2.28**△△# 6.13 < 0.01 9.418 dDBPV 10.25±1.21# 9.67±1.38# 9.54±1.87# 1.62 >0.05 2.289 不同时间点q检验:与入院时比较*P < 0.05,**P < 0.01;与术后1周时比较△P < 0.05,△△P < 0.01。组间q检验:与缺乏组比较#P < 0.05 表 3 3组病人24 h动态血压变化比较
($ \overline{x}\pm s$) -
入院时25(OH)D水平与入院时、术后1周、术后4周的24 h动态血压指标均呈现负相关(P < 0.05~P < 0.01)(见表 4)。
指标 rs P 入院时 24hSBP -0.468 < 0.01 24hDBP -0.421 < 0.01 dSBP -0.435 < 0.01 dDBP -0.443 < 0.01 nSBP -0.431 < 0.01 nDBP -0.347 < 0.01 24hSBPV -0.438 < 0.01 24hDBPV -0.441 < 0.01 dSBPV -0.385 < 0.05 dDBPV -0.325 < 0.01 术后1周 24hSBP -0.435 < 0.01 24hDBP -0.511 < 0.01 dSBP -0.425 < 0.01 dDBP -0.322 < 0.01 nSBP -0.328 < 0.01 nDBP -0.335 < 0.01 24hSBPV -0.352 < 0.01 24hDBPV -0.454 < 0.01 dSBPV -0.387 < 0.01 dDBPV -0.332 < 0.01 术后4周 24hSBP -0.457 < 0.01 24hDBP -0.454 < 0.01 dSBP -0.384 < 0.01 dDBP -0.464 < 0.01 nSBP -0.414 < 0.01 nDBP -0.464 < 0.01 24hSBPV -0.421 < 0.01 24hDBPV -0.325 < 0.01 dSBPV -0.438 < 0.01 dDBPV -0.384 < 0.01 表 4 25(OH) D水平与24 h动态血压相关性分析
维生素D水平与PCI术后病人早期24 h动态血压变化的相关性研究
Study on the correlation between vitamin D level and early 24-hour ambulatory blood pressure changes in patients after PCI
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摘要:
目的探讨维生素D水平与经皮冠状动脉介入治疗(PCI)术后病人早期24 h动态血各指标变化的相关性。 方法回顾性分析经PCI治疗的急性心肌梗死住院病人的临床资料。在病人入院时测量25-羟维生素D[25(OH)D]。使用美国DMS-ABP型动态血压监测仪监测入院时、术后1周及术后4周的24 h动态血压各指标。 结果26例病人25(OH)D正常,21例病人25(OH)D不足,33例病人25(OH)D缺乏。白细胞计数水平为缺乏组病人高于其余2组病人(P < 0.05),CRP水平为正常组病人低于其他两组(P < 0.05)。对入院时、术后1周及术后4周的24 h动态血压组内比较显示,3组病人的24 h平均舒张压(24hDBP)、白昼平均收缩压(dSBP)、白昼平均舒张压(dDBP)、夜间舒张压(nDBP)4个指标在3个时间点的24 h动态血压差异均无统计学意义(P>0.05),正常组除上述4个指标外24hSBP在3个时间点差异也无统计学意义(P>0.05),3组病人的其余各指标在3个时间点的24h动态血压差异均有统计学意义(P < 0.05~P < 0.01);组间比较显示,25(OH)D缺乏组病人各时间点的24 h动态血压各指标均高于25(OH)D正常组病人(P < 0.05)。入院时25(OH)D水平与入院时、术后1周、术后4周的24 h动态血压指标均呈现负相关(P < 0.05~P < 0.01)。 结论维生素D与PCI术后24 h动态血压各指标变化具有相关性。入院时常规补充维生素D可能有利于PCI术后血压调节,维持24 h动态血压平衡。 Abstract:ObjectiveTo investigate the correlation between vitamin D level and early 24-hour dynamic blood parameters in patients after percutaneous coronary intervention(PCI). MethodsThe clinical data of inpatients with acute myocardial infarction treated with PCI were collected.The level of 25-hydroxyvitamin D[25(OH) D] was measured at admission.The 24-hour ambulatory blood pressure indicators at admission, and after 1 week and 4 weeks of operation were monitored using the American DMS-ABP ambulatory blood pressure monitor. ResultsThe normal, insufficient and deficiency levels of 25(OH) D in 26, 21 and 33 patients were identified, respectively.The level of WBC in deficiency group was higher than that in other two groups(P < 0.05), and the level of CRP in normal group was lower than that in other two groups(P < 0.05).The differences of the 24-hour ambulatory blood pressure indictors, which included 24-hour average diastolic blood pressure(24hDBP), daytime average systolic blood pressure(dSBP), daytime average diastolic blood pressure(dDBP) and nighttime diastolic blood pressure(nDBP) in three groups at admission, and after 1 week and 4 weeks of operation were not statistically significant (P>0.05).In addition to the above four indicators, the difference of the 24hSBP in normal group at three time-points was not statistically significant(P>0.05), and the differences of other indictors of the 24-hour ambulatory blood pressure in three groups at three time-points were statistically significant(P < 0.05 to P < 0.01).The results of comparisons between groups showed that the 24-hour ambulatory blood pressure indictors in 25(OH) D deficiency group at each time-point were higher than those in 25(OH) D normal group(P < 0.05).The level of 25(OH) D was negatively correlated with the 24-hour ambulatory blood pressure at admission, and after 1 week and 4 weeks of operation(P < 0.05 to P < 0.01). ConclusionsThe level of vitamin D is correlated with the changes of 24-hours ambulatory blood pressure after PCI.Therefore, the routine vitamin D supplementation at admission may be beneficial to regulate the blood pressure after PCI, and maintain the 24-hour ambulatory blood pressure balance. -
表 1 不同25(OH)D组一般资料比较
( )$ \overline{x}\pm s$ 分组 n 年龄 男性 BMI 血脂异常 糖尿病 肾病 吸烟 入院时治疗药物 生化指标 ACEI ARB β受体阻断剂 硝酸酯类 他汀类药物 CCB 利尿剂 氯吡格雷 Glu/(mg/dL) Cre/(mg/dL) LDL-C/(mg/dL) HDL-C/(mg/dL) TG/(mg/dL) TC/(mg/dL) WBC/(×109) Hb/(g/dL) CRP/(mg/L) 肌钙蛋白1/(nh/mL) CK-MB/(U/L) 缺乏 33 67.58±10.87 21 27.55±4.38 19 10 6 11 13 6 16 10 18 6 10 8 122.45±56.47 0.84±0.52 97.85±32.85 38.58±8.67 148.55±45.68 169.85±52.28 8.89±2.28 12.89±1.85 1.47±0.66 4.86±21.52 27.58±47.85 不足 21 64.22±11.58 18 26.75±4.51 15 9 5 12 9 5 12 7 14 5 7 6 119.78±51.47 0.83±0.52 91.52±39.84 39.58±8.74 138.74±52.84 156.88±44.85 7.38±2.27* 13.25±1.74 1.35±0.53 4.56±20.87 22.87±49.68 正常 26 63.88±12.47 20 27.88±4.76 18 11 7 12 11 6 15 8 16 6 9 7 120.25±50.68 0.82±0.52 86.88±36.58 40.25±9.85 137.84±50.69 154.85±41.48 7.33±2.11△ 13.54±1.71 1.06±0.49△# 4.54±19.85 23.84±51.22 F — 0.91 3.43* 0.37 1.39* 1.24* 0.67* 3.05* 0.08* 0.32* 0.63* 0.06* 1.38* 0.25* 0.13* 0.13* 0.02 0.01 0.69 0.25 0.43 0.88 4.64 0.99 3.77 0.00 0.07 P — >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05 <0.05 >0.05 <0.05 >0.05 >0.05 MS组内 — 134.422 — 20.612 — — — — — — — — — — — — 2 847.251 0.270 1 295.180 82.581 2 426.642 2 216.981 4.944 3.158 0.332 433.523 2 444.379 *示χ2值;q检验:与缺乏组比较△P < 0.05;与不足组比较#P < 0.05 表 2 入组病人24 h动态血压变化情况
(ni=80; )$ \overline{x}\pm s$ 分组 24hSBP/mmHg 24hDBP/mmHg dSBP/mmHg dDBP/mmHg nSBP/mmHg nDBP/mmHg 24hSBPV 24hDBPV dSBPV dDBPV 入院时 137.40±9.89 83.29±8.52 141.45±9.54 84.33±8.22 133.46±8.51 80.54±8.04 16.43±2.16 12.43±1.98 15.22±2.05 11.52±2.11 术后1周 135.34±10.02 83.35±8.43 137.38±9.45** 84.66±8.12 132.62±8.45 81.38±8.08 15.42±1.99** 12.40±2.01 14.49±1.89* 10.85±2.02* 术后4周 130.94±10.24**△△ 80.32±8.24* 133.55±10.02**△ 80.81±8.07**△△ 123.84±8.39**△△ 77.53±7.96*△△ 12.14±2.08**△△ 11.23±2.05**△△ 12.42±2.24**△△ 10.40±2.04** F 8.62 3.40 13.34 5.50 31.81 5.09 93.21 9.24 39.58 6.01 P < 0.01 < 0.05 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 MS组内 101.023 70.518 93.572 66.209 71.405 64.430 4.317 4.054 4.264 4.231 q检验:与入院时比较*P < 0.05,**P < 0.01;与术后1周时比较△P < 0.05,△△P < 0.01 表 3 3组病人24 h动态血压变化比较
( )$ \overline{x}\pm s$ 分组 入院时 术后1周 术后4周 F P MS组内 缺乏(n=33) 24hSBP/mmHg 141.44±9.38 139.71±10.54 133.76±8.54**△ 5.91 <0.01 90.670 24hDBP/mmHg 85.79±8.34 87.22±8.24 84.48±8.11 0.91 >0.05 67.742 dSBP/mmHg 142.55±10.23 141.49±9.84 138.71±9.30 1.35 >0.05 95.990 dDBP/mmHg 88.86±8.54 88.84±8.34 85.11±7.68 2.29 >0.05 67.157 nSBP/mmHg 135.64±9.64 134.85±8.33 127.63±9.85**△△ 7.44 <0.01 86.447 nDBP/mmHg 83.64±7.21 84.22±8.17 80.34±7.26 2.53 >0.05 57.147 24hSBPV 17.61±3.37 16.64±2.67 13.15±2.64**△△ 21.40 <0.01 8.485 24hDBPV 13.95±1.27 13.84±1.12 12.17±2.05**△△ 13.93 < 0.01 2.357 dSBPV 16.67±3.38 15.27±3.25 13.84±2.54** 6.97 < 0.01 9.480 dDBPV 12.67±1.45 11.57±1.41** 10.79±2.07** 10.55 < 0.01 2.792 不足(n=21) 24hSBP/mmHg 139.55±10.51 135.84±11.24 131.84±8.77* 2.99 >0.05 104.570 24hDBP/mmHg 82.48±8.51 83.14±7.95 80.54±8.33 0.56 >0.05 68.337 dSBP/mmHg 140.67±9.84 139.57±10.31 131.64±9.54 2.21 >0.05 90.044 dDBP/mmHg 83.84±9.67 84.79±8.64 84.51±7.71 0.07 >0.05 75.868 nSBP/mmHg 134.78±8.94 133.88±9.86 125.61±10.05*△△ 5.79 < 0.01 92.715 nDBP/mmHg 79.86±6.11 80.28±8.28 78.54±7.51 0.32 >0.05 54.097 24hSBPV 16.58±3.41 15.44±2.58 12.61±2.53**△△ 10.66 < 0.01 8.229 24hDBPV 12.38±1.29 12.94±1.21 11.08±2.21*△△ 7.16 <0.01 2.671 dSBPV 15.47±3.22 15.29±3.14 12.64±2.48**△△ 6.00 < 0.01 8.793 dDBPV 11.27±1.33 11.17±1.31 10.84±2.17 0.39 >0.05 2.731 正常(n=26) 24hSBP/mmHg 130.54±9.84 129.38±11.05 126.64±8.68 1.06 >0.05 98.090 24hDBP/mmHg 79.54±8.67# 78.62±8.39# 77.94±8.28# 0.23 >0.05 71.373 dSBP/mmHg 131.51±10.94# 130.38±9.79# 128.55±9.63# 0.56 >0.05 102.755 dDBP/mmHg 78.98±8.47# 79.24±8.44# 78.51±7.52# 0.05 >0.05 66.508 nSBP/mmHg 129.64±9.94# 128.76±8.68# 117.61±10.25**△△# 12.56 < 0.01 93.070 nDBP/mmHg 77.15±7.17# 78.65±8.64# 73.14±8.02△# 3.32 < 0.05 63.460 24hSBPV 14.82±3.18# 13.84±2.62# 10.47±2.52**△△# 17.41 < 0.01 7.776 24hDBPV 10.54±1.07# 10.14±1.08# 10.17±2.11# 0.57 >0.05 2.255 dSBPV 13.17±3.12# 12.84±3.65# 10.44±2.28**△△# 6.13 < 0.01 9.418 dDBPV 10.25±1.21# 9.67±1.38# 9.54±1.87# 1.62 >0.05 2.289 不同时间点q检验:与入院时比较*P < 0.05,**P < 0.01;与术后1周时比较△P < 0.05,△△P < 0.01。组间q检验:与缺乏组比较#P < 0.05 表 4 25(OH) D水平与24 h动态血压相关性分析
指标 rs P 入院时 24hSBP -0.468 < 0.01 24hDBP -0.421 < 0.01 dSBP -0.435 < 0.01 dDBP -0.443 < 0.01 nSBP -0.431 < 0.01 nDBP -0.347 < 0.01 24hSBPV -0.438 < 0.01 24hDBPV -0.441 < 0.01 dSBPV -0.385 < 0.05 dDBPV -0.325 < 0.01 术后1周 24hSBP -0.435 < 0.01 24hDBP -0.511 < 0.01 dSBP -0.425 < 0.01 dDBP -0.322 < 0.01 nSBP -0.328 < 0.01 nDBP -0.335 < 0.01 24hSBPV -0.352 < 0.01 24hDBPV -0.454 < 0.01 dSBPV -0.387 < 0.01 dDBPV -0.332 < 0.01 术后4周 24hSBP -0.457 < 0.01 24hDBP -0.454 < 0.01 dSBP -0.384 < 0.01 dDBP -0.464 < 0.01 nSBP -0.414 < 0.01 nDBP -0.464 < 0.01 24hSBPV -0.421 < 0.01 24hDBPV -0.325 < 0.01 dSBPV -0.438 < 0.01 dDBPV -0.384 < 0.01 -
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