急性冠状动脉综合征的炎症机制及氟伐他汀的抗炎作用

王廷涛; 张效明; 张俊; 刘群; 武文君; 陈燕; 熊守庆

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急性冠状动脉综合征的炎症机制及氟伐他汀的抗炎作用

王廷涛 , 张效明 , 张俊 , 刘群 , 武文君 , 陈燕 , 熊守庆

文章导航 > 蚌埠医学院学报 > 2009, 34 > 6: (501-503)

引用本文:

Citation:

急性冠状动脉综合征的炎症机制及氟伐他汀的抗炎作用

1. 蚌埠医学院第二附属医院心血管内科, 安徽蚌埠 233040;
2. 蚌埠医学院第二附属医院检验科, 安徽蚌埠 233040

作者简介: 王廷涛(1970-),男,主治医师.

中图分类号: R543.3

The mechanism of inflammation during acute coronaria syndrome and the anti-inflammation role of fluvastatin

1. Department of Cardiovascular Diseases, The Second Affiliated Hospital of Bengbu Mdical College, Bengbu Anhui 233040, China;
2. Department of Clinical Laboratories, The Second Affiliated Hospital of Bengbu Mdical College, Bengbu Anhui 233040, China
CLC number: R543.3

摘要: 目的:探讨急性冠状动脉综合征(acute coronary syndrome,ACS)的炎症机制及氟伐他汀的抗炎作用。方法:选择稳定型心绞痛(SAP)72例为对照组,ACS 84例为治疗组,包括不稳定型心绞痛(UAP)39例,非ST段抬高性心肌梗死(NSTEMI)25例,ST段抬高性心肌梗死(STEMI)20例。治疗组在常规治疗的基础上给予氟伐他汀40mg,晚餐后服用,疗程4周。分别测定治疗前后患者血浆中高敏C反应蛋白(hs-CRP)、胆固醇(CHO)和低密度脂蛋白(LDL-C)水平。结果:治疗前ACS各组hs-CRP水平明显高于SAP组(P<0.01),STEMI组hs-CRP与NSTEMI组和UAP组差异均无统计学意义(P>0.05),ACS各组CHO、LDL-C水平与SAP组差异均无统计学意义(P>0.05),治疗后ACS各组hs-CRP、CHO、LDL-C均明显下降(P<0.01)。结论:炎症反应在ACS的发病中起重要作用,氟伐他汀既有调脂作用,又有抗炎作用。
- 冠状动脉疾病 /
- 急性冠状动脉综合征 /
- 炎症 /
- 高敏C反应蛋白 /
- 氟伐他汀
Abstract: Objective: To observe the mechanism of inflammation during acute coronaria syndrome(ACS) and the anti-inflammation role of fluvastatin.Methods: Seventy-two cases of stable angina pectoris(SAP) were selected as control,and 84 cases of ACS were enrolled in the treatment group which included 39 cases of unstable angina pectoris(UAP),25 cases of non-ST elevated myocardial infarction(NSTEMI) and 20 cases of ST elevated myocardial infarction(STEMI).The treatment group was prescribed fluvastatin 40 mg in addition to the routine therapy.The fluvastatin was taken after supper and the treatment course lasted for 4 weeks.The concentrations of high sensitive C reactive protein(hs-CRP),cholesterol(CHO) and low density lipoprotein(LDL-C) in the blood of the patients were determined before and after treatment separately.Results: Before treatment,the concentration of hs-CRP in ACS group was obviously higher than that in SAP group(P<0.01),while the hs-CRP in STEMI group had no statistic significance compared with that in NSTEMI or UAP groups(P>0.05);the concentrations of CHO and LDL-C in ACS group were not significantly different compared with that in SAP group(P>0.05).After treatment,the concentrations of hs-CRP,CHO and LDL-C in ACS groups were lowered obviously(P<0.01).Conclusions: Inflammation plays an important role in the process of ACS,and fluvastatin possesses the ability of moderating cholesterol and anti-inflammation.
- coronary disease /
- acute coronary syndrome /
- inflammation /
- high-sensitive C reactive protein /
- fluvastatin

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[6]	牛海军 , 吴桥 , 江荣炎 , 卜令同 . 血浆脂蛋白a、高敏C反应蛋白、脑钠肽水平与冠状动脉病变程度的相关性研究. 蚌埠医学院学报, 2015, 40(5): 629-632. doi: 10.13898/j.cnki.issn.1000-2200.2015.05.023
[7]	郭荣贞 . 急性冠状动脉综合征9例急救与护理体会. 蚌埠医学院学报, 2011, 36(1): 86-87.
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[13]	廉迎冬 . 瑞舒伐他汀联合依折麦布治疗急性冠状动脉综合征的效果观察. 蚌埠医学院学报, 2017, 42(9): 1217-1219. doi: 10.13898/j.cnki.issn.1000-2200.2017.09.019
[14]	丁大伟 , 包宗明 . 血清骨保护素和糖化血红蛋白水平与急性冠状动脉综合征的关系探讨. 蚌埠医学院学报, 2013, 37(5): 542-544.
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急性冠状动脉综合征的炎症机制及氟伐他汀的抗炎作用

作者简介: 王廷涛(1970-),男,主治医师.

1. 蚌埠医学院第二附属医院心血管内科, 安徽蚌埠 233040;
2. 蚌埠医学院第二附属医院检验科, 安徽蚌埠 233040

收稿日期: 2008-10-10

关键词:

摘要: 目的:探讨急性冠状动脉综合征(acute coronary syndrome,ACS)的炎症机制及氟伐他汀的抗炎作用。方法:选择稳定型心绞痛(SAP)72例为对照组,ACS 84例为治疗组,包括不稳定型心绞痛(UAP)39例,非ST段抬高性心肌梗死(NSTEMI)25例,ST段抬高性心肌梗死(STEMI)20例。治疗组在常规治疗的基础上给予氟伐他汀40mg,晚餐后服用,疗程4周。分别测定治疗前后患者血浆中高敏C反应蛋白(hs-CRP)、胆固醇(CHO)和低密度脂蛋白(LDL-C)水平。结果:治疗前ACS各组hs-CRP水平明显高于SAP组(P<0.01),STEMI组hs-CRP与NSTEMI组和UAP组差异均无统计学意义(P>0.05),ACS各组CHO、LDL-C水平与SAP组差异均无统计学意义(P>0.05),治疗后ACS各组hs-CRP、CHO、LDL-C均明显下降(P<0.01)。结论:炎症反应在ACS的发病中起重要作用,氟伐他汀既有调脂作用,又有抗炎作用。

English Abstract

The mechanism of inflammation during acute coronaria syndrome and the anti-inflammation role of fluvastatin

1. Department of Cardiovascular Diseases, The Second Affiliated Hospital of Bengbu Mdical College, Bengbu Anhui 233040, China;
2. Department of Clinical Laboratories, The Second Affiliated Hospital of Bengbu Mdical College, Bengbu Anhui 233040, China

Received Date: 2008-10-10

Abstract: Objective: To observe the mechanism of inflammation during acute coronaria syndrome(ACS) and the anti-inflammation role of fluvastatin.Methods: Seventy-two cases of stable angina pectoris(SAP) were selected as control,and 84 cases of ACS were enrolled in the treatment group which included 39 cases of unstable angina pectoris(UAP),25 cases of non-ST elevated myocardial infarction(NSTEMI) and 20 cases of ST elevated myocardial infarction(STEMI).The treatment group was prescribed fluvastatin 40 mg in addition to the routine therapy.The fluvastatin was taken after supper and the treatment course lasted for 4 weeks.The concentrations of high sensitive C reactive protein(hs-CRP),cholesterol(CHO) and low density lipoprotein(LDL-C) in the blood of the patients were determined before and after treatment separately.Results: Before treatment,the concentration of hs-CRP in ACS group was obviously higher than that in SAP group(P<0.01),while the hs-CRP in STEMI group had no statistic significance compared with that in NSTEMI or UAP groups(P>0.05);the concentrations of CHO and LDL-C in ACS group were not significantly different compared with that in SAP group(P>0.05).After treatment,the concentrations of hs-CRP,CHO and LDL-C in ACS groups were lowered obviously(P<0.01).Conclusions: Inflammation plays an important role in the process of ACS,and fluvastatin possesses the ability of moderating cholesterol and anti-inflammation.