高血压病脑梗死患者与超敏C反应蛋白颈动脉内-中膜厚度的相关性

蒋宏俨; 寿广丽; 冯敏; 孟颖

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高血压病脑梗死患者与超敏C反应蛋白颈动脉内-中膜厚度的相关性

蒋宏俨 , 寿广丽 , 冯敏 , 孟颖

文章导航 > 蚌埠医学院学报 > 2013, 37 > 10: (1277-1279)

引用本文:

Citation:

高血压病脑梗死患者与超敏C反应蛋白颈动脉内-中膜厚度的相关性

1.
蚌埠医学院第二附属医院神经内科，安徽蚌埠233040

作者简介: 蒋宏俨(1979-) ，男，主治医师.

基金项目:

Relationship between high-sensitivity C-reactive protein and carotid intima-media thickness in patients with essential hypertension complicated with cerebral infarction

1.
Department of Neurology，The Second Affiliated Hospital of Bengbu Medical College，Bengbu Anhui 233040，China

摘要: 目的:探讨高血压病(EH)脑梗死(ECI)患者血清超敏C反应蛋白(hs-CrP)与颈动脉内-中膜厚度(IMT)的相关性。方法:选择47例EH患者,其中合并ECI(ECI组)25例,未合并ECI的EH组22例;另选择体检中心健康体检者20名为对照组。检测3组患者三酰甘油、低密度脂蛋白、空腹血糖、hs-CrP水平和颈动脉IMT。结果:3组年龄、性别构成、吸烟史、三酰甘油、低密度脂蛋白、空腹血糖比较差异均无统计学意义(P0.05)。ECI组hs-CrP和颈动脉IMT均高于对照组和EH组(P0.05~P0.01),EH组hs-CrP和颈动脉IMT也均高于对照组(P0.05和P0.01)。EH组中,颈动脉IMT增高组的血清hs-CrP明显高于IMT正常组(P0.01),hs-CrP与颈动脉IMT呈正相关关系(P0.01)。以颈动脉IMT为因变量的多重逐步回归分析结果显示,患者的年龄和hs-CrP即进入回归方程,回归方程为^IMT=0.319+0.064Xhs-CrP+0.008X年龄。结论:hsCrP可能通过促进颈动脉粥样硬化影响ECI的发生、发展。
- 脑梗死 /
- 超敏C反应蛋白 /
- 高血压 /
- 颈动脉 /
- 内-中膜厚度
Abstract: Objective: To investigate the relationship between high-sensitivity C-reactive protein(hs-CrP) and carotid intima-media thickness(IMT) in patients with essential hypertension(EH) complicated with cerebral infarction. Methods: Twenty five patients with EH complicated with cerebral infarction(ECI group) ，22 patients with EH(EH group) and 20 healthy people(control group) were selected. The levels of serum hs-CrP, triglyceride, low-density lipoprotein, fasting blood glucose and carotid IMT in three groups were detected. results: The differences of age, sex, smoking history, levels of triglyceride, low density lipoprotein and fasting blood glucose in three groups had no statistical significance(P ＞ 0. 05) . The levels of hs-CrP and carotid IMT of the ECI group were significantly higher than those in control and EH group(P ＜ 0. 05 to P ＜ 0. 01) , the levels of hs-CrP and carotid IMT of the EH group were significantly higher than those in control group(P ＜ 0. 05 and P ＜ 0. 01) . In EH group, the level of hs-CrP in patients with increasing carotid IMT was significantly higher than that in patients with normal carotid IMT, the level of carotid IMT was positively correlated with hs-CrP (P ＜ 0. 01) . The multiple regression analysis showed that carotid IMT was correlated with age and hs-CrP, the regression equation was Y^IMT = 0. 319 + 0. 064Xhs-CrP + 0. 008Xage . Conclusions: hs-CrP may affect the pathogenesis and development of cerebral infarction in ECI patients by promoting the carotid atherosclerosis.
- cerebral infarction /
- high-sensitivity C-reactive protein /
- essential hypertension /
- carotid artery /
- intima-media thickness

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高血压病脑梗死患者与超敏C反应蛋白颈动脉内-中膜厚度的相关性

作者简介: 蒋宏俨(1979-) ，男，主治医师.

1. 蚌埠医学院第二附属医院神经内科，安徽蚌埠233040

收稿日期: 2012-07-29
网络出版日期: 2013-10-15

基金项目:

关键词:

摘要: 目的:探讨高血压病(EH)脑梗死(ECI)患者血清超敏C反应蛋白(hs-CrP)与颈动脉内-中膜厚度(IMT)的相关性。方法:选择47例EH患者,其中合并ECI(ECI组)25例,未合并ECI的EH组22例;另选择体检中心健康体检者20名为对照组。检测3组患者三酰甘油、低密度脂蛋白、空腹血糖、hs-CrP水平和颈动脉IMT。结果:3组年龄、性别构成、吸烟史、三酰甘油、低密度脂蛋白、空腹血糖比较差异均无统计学意义(P0.05)。ECI组hs-CrP和颈动脉IMT均高于对照组和EH组(P0.05~P0.01),EH组hs-CrP和颈动脉IMT也均高于对照组(P0.05和P0.01)。EH组中,颈动脉IMT增高组的血清hs-CrP明显高于IMT正常组(P0.01),hs-CrP与颈动脉IMT呈正相关关系(P0.01)。以颈动脉IMT为因变量的多重逐步回归分析结果显示,患者的年龄和hs-CrP即进入回归方程,回归方程为^IMT=0.319+0.064Xhs-CrP+0.008X年龄。结论:hsCrP可能通过促进颈动脉粥样硬化影响ECI的发生、发展。

English Abstract

Relationship between high-sensitivity C-reactive protein and carotid intima-media thickness in patients with essential hypertension complicated with cerebral infarction

1. Department of Neurology，The Second Affiliated Hospital of Bengbu Medical College，Bengbu Anhui 233040，China

Received Date: 2012-07-29
Available Online: 2013-10-15

Abstract: Objective: To investigate the relationship between high-sensitivity C-reactive protein(hs-CrP) and carotid intima-media thickness(IMT) in patients with essential hypertension(EH) complicated with cerebral infarction. Methods: Twenty five patients with EH complicated with cerebral infarction(ECI group) ，22 patients with EH(EH group) and 20 healthy people(control group) were selected. The levels of serum hs-CrP, triglyceride, low-density lipoprotein, fasting blood glucose and carotid IMT in three groups were detected. results: The differences of age, sex, smoking history, levels of triglyceride, low density lipoprotein and fasting blood glucose in three groups had no statistical significance(P ＞ 0. 05) . The levels of hs-CrP and carotid IMT of the ECI group were significantly higher than those in control and EH group(P ＜ 0. 05 to P ＜ 0. 01) , the levels of hs-CrP and carotid IMT of the EH group were significantly higher than those in control group(P ＜ 0. 05 and P ＜ 0. 01) . In EH group, the level of hs-CrP in patients with increasing carotid IMT was significantly higher than that in patients with normal carotid IMT, the level of carotid IMT was positively correlated with hs-CrP (P ＜ 0. 01) . The multiple regression analysis showed that carotid IMT was correlated with age and hs-CrP, the regression equation was Y^IMT = 0. 319 + 0. 064Xhs-CrP + 0. 008Xage . Conclusions: hs-CrP may affect the pathogenesis and development of cerebral infarction in ECI patients by promoting the carotid atherosclerosis.