血清N端脑钠肽与维持性血液透析患者左心室肥厚的关系

蒋卫杰; 宋锦叶; 王月妹

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血清N端脑钠肽与维持性血液透析患者左心室肥厚的关系

蒋卫杰 , 宋锦叶 , 王月妹

文章导航 > 蚌埠医学院学报 > 2013, 37 > 10: (1317-1320)

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血清N端脑钠肽与维持性血液透析患者左心室肥厚的关系

1.
上海市闸北区市北医院肾内科, 200443

作者简介: 蒋卫杰(1966-) ，女，副主任医师

基金项目:

The association between serum N-terminal pro brain natriuretic peptide level and left ventricular hypertrophy in maintenance hemodialysis patients

1.
Department of Nephrology，Shibei Hospital，Zhabei District，Shanghai 200443，China

摘要: 目的:探讨维持性血液透析(MHD)患者血清N端脑钠肽(NT-proBNP)水平与左心室心肌质量指数(LVMI)之间的关系。方法:检测81例MHD患者血清NT-proBNP水平,应用超声心动图测定并计算LVMI,动态观察其中55例LVMI评价为左心室肥厚(LVH)患者,经坎地沙坦联合左卡尼汀治疗4个月前、后LVMI及NT-proBNP水平,并对血清NT-proBNP水平与LVMI进行相关性分析。结果:MHD患者血清NT-proBNP水平及LVMI均显著高于健康对照组(P0.01);LVH患者NTproBNP水平明显高于无LVH患者(P0.01),同时NT-proBNP水平与LVMI呈正相关关系(P0.01);LVH组患者予坎地沙坦联合左卡尼汀治疗4个月后,NT-proBNP及LVMI均明显降低(P0.01)。结论:MHD患者血清NT-proBNP水平普遍升高,合并LVH则血清NT-proBNP水平明显升高,且与LVMI呈正相关,NT-proBNP水平对MHD患者LVH的评估具有临床意义。
- 血液透析 /
- N-端脑钠肽 /
- 左心室心肌质量指数 /
- 左心室肥厚
Abstract: Objective: To investigate the relationship between serum N-terminal pro brain natriuretic peptide(NT-proBNP) levels and left ventricle mass index(LVMI) in maintenance hemodialysis(MHD) patients. Methods: A total of 81 MHD patients were recruited, and the serum NT-proBNP levels were measured，echocardiography was performed and LVMI was calculated. The serum NT-proBNP levels in 55 MHD patients with left ventricular hypertrophy(LVH) according to LVMI were observed dynamically before and after treament of candesartan and levocarnitine for 4 months, the correlation between serum NT-proBNP level and LVMI in these patients was analyzed. results: Both of the serum NT-proBNP level and LVMI in MHD patients were significantly higher than that in control group (P ＜ 0. 01) . The serum NT-proBNP level in MHD patients with LVH was significantly higher than that in the MHD patients without LVH(P ＜ 0. 01) , and was positively correlated with LVMI(P ＜ 0. 01) . After treatment of candesartan and levocarnitine for 4 months, both of the serum NT-proBNP level and LVMI were significantly decreased than before (P ＜ 0. 01) . Conclusions: The serum NTproBNP level was significantly increased in MHD patients，especially in patients with LVH，and was positive correlation with LVMI, serum NT-proBNP level may be used for assessment LVH in MHD patients.
- hemodialysis /
- N-terminal pro brain natriuretic peptide /
- left ventricle mass index /
- left ventricular hypertrophy

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血清N端脑钠肽与维持性血液透析患者左心室肥厚的关系

作者简介: 蒋卫杰(1966-) ，女，副主任医师

1. 上海市闸北区市北医院肾内科, 200443

收稿日期: 2013-02-05
网络出版日期: 2013-10-15

基金项目:

关键词:

摘要: 目的:探讨维持性血液透析(MHD)患者血清N端脑钠肽(NT-proBNP)水平与左心室心肌质量指数(LVMI)之间的关系。方法:检测81例MHD患者血清NT-proBNP水平,应用超声心动图测定并计算LVMI,动态观察其中55例LVMI评价为左心室肥厚(LVH)患者,经坎地沙坦联合左卡尼汀治疗4个月前、后LVMI及NT-proBNP水平,并对血清NT-proBNP水平与LVMI进行相关性分析。结果:MHD患者血清NT-proBNP水平及LVMI均显著高于健康对照组(P0.01);LVH患者NTproBNP水平明显高于无LVH患者(P0.01),同时NT-proBNP水平与LVMI呈正相关关系(P0.01);LVH组患者予坎地沙坦联合左卡尼汀治疗4个月后,NT-proBNP及LVMI均明显降低(P0.01)。结论:MHD患者血清NT-proBNP水平普遍升高,合并LVH则血清NT-proBNP水平明显升高,且与LVMI呈正相关,NT-proBNP水平对MHD患者LVH的评估具有临床意义。