牙周基础治疗对牙周炎病人PLI、PD及静脉血和龈沟液中hs-CRP表达水平的影响
Effect of periodontal basic treatment on the PLI,PD, and expression levels of hs-CRP in serum and gingival crevicular fluid
-
摘要: 目的：探讨牙周基础治疗对牙周炎病人菌斑指数（PLI）、牙周探诊深度（PD）以及静脉血和龈沟液中超敏C反应蛋白（hs-CRP）的影响。方法：选取慢性牙周炎病人64例（病例组）和64名牙周健康者作为对照组，病例组给予牙周基础治疗，观察2组PLI、PD、附着丧失（AL）以及血清、龈沟液hs-CRP、白细胞介素-6（IL-6）、IL-8水平。结果：治疗前后病例组PD、PLI和AL均明显高于对照组（P < 0.01）；病例组治疗后PD、PLI和AL均较治疗前明显下降（P < 0.01）。治疗前后血清及龈沟液IL-6、IL-8及hs-CRP均明显高于对照组（P < 0.01）；病例组治疗后血清及龈沟液IL-6、IL-8及hs-CRP均较治疗前显著下降（P < 0.01）。PD与血清及龈沟液IL-6、IL-8及hs-CRP呈正相关（P < 0.05），AL与血清及龈沟液IL-6、IL-8及hs-CRP呈正相关（P < 0.05）。结论：牙周基础治疗能有效改善牙周炎病人牙周情况以及炎症状态。Abstract: Objective: To investigate the effects of periodontal basic treatment on plaque index(PLI),periodontal probing depth(PD) and expression levels of high sensitivity C reactive protein(hs-CRP) in serum and gingival crevicular fluid in patients with periodontitis.Methods: Sixty-four patients with chronic periodontitis and 64 healthy volunteers were divided into the case group and control group,respectively.The case group was treated with periodontal basic treatment.The PLI,PD,attachment loss(AL) and levels of hs-CRP,interleukin-6(IL-6),interleukin-8(IL-8) in serum and gingival crevicular fluid were observed in two groups.Results: Before and after treatment,the PD,PLI and AL in case group were significantly higher than those in control group(P<0.01).The PD,PLI and AL in case group after treatment significantly decreased compared with before treatment(P<0.01).Before and after treatment,the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group were significantly higher than those in control group(P<0.01).The levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group after treatment significantly decreased compared with before treatment(P<0.01).The PD was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05),and the AL was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05).Conclusions: Periodontal basic treatment can effectively improve the periodontal and inflammatory status in patients with periodontitis.
-
Key words:
- periodontitis /
- periodontal basic treatment /
- inflammatory factor /
- serum /
- gingival crevicular fluid
-
[1] CALAPKORUR MU,ALKAN BA,TASDEMIR Z,et al.Association of peripheral arterial disease with periodontal disease:analysis of inflammatory cytokines and an acute phase protein in gingival crevicular fluid and serum[J].J Periodontal Res,2016,22(6):89. [2] OZCAKA O,CEYHAN-OZTURK B,GUMUS P,et al.Clinical periodontal status and inflammatory cytokines in gestational diabetes mellitus[J].Arch Oral Biol,2016,72(5):87. [3] 叶菁,张戎,褚云娟,等.正常和炎症来源的人牙周膜干细胞内皮向分化能力的比较[J].牙体牙髓牙周病学杂志,2014,24(1):7. [4] 刘亚丽,刘文佳,胡成虎,等.牙周慢性炎症对牙周膜干细胞生物学特性的影响[J].牙体牙髓牙周病学杂志,2014,24(1):21. [5] 陈蕾,苏媛,倪佳,等.牙周基础治疗对伴2型糖尿病的中、重度牙周炎病人牙周炎症控制、血清炎症指标及代谢水平影响[J].华西口腔医学杂志,2014,32(1):66. [6] 刘娜,石海刚,张维,等.炎症微环境作用下经典及非经典Wnt通路平衡对牙周膜干细胞成骨分化的调控作用[J].中华口腔医学杂志,2016,51(11):673. [7] JIANG L,SONG J,HU X,et al.The proteasome inhibitor bortezomib inhibits inflammatory response of periodontal ligament cells and ameliorates experimental periodontitis in rats[J].J Periodontol,2016,22(5):1. [8] ZHOU W,ZHANG X,ZHU C L,et al.Melatonin receptor agonists as the "perioceutics" agents for periodontal disease through modulation of porphyromonas gingivalis virulence and inflammatory response[J].PLoS One,2016,11(11):6442. [9] 廖蔚文,宋忠臣,束蓉,等.炎症微环境下重组人釉原蛋白对人牙周膜成纤维细胞炎症因子表达的影响[J].上海交通大学学报(医学版),2016,36(1):33. [10] 任静宜,刘歆婵,丁烨,等.细胞自噬和炎症反应的相互调控与牙周炎[J].国际口腔医学杂志,2016,43(4):462. [11] 辛月娇,刘一颖,徐屹.中性粒细胞功能的研究进展及其平衡失调与牙周炎的关系[J].华西口腔医学杂志,2016,34(2):210. [12] 张家祥.牙槽骨吸收牙周炎模型大鼠牙周组织和血清白细胞介素17的表达[J].中国组织工程研究,2015,19(24):3803. [13] 刘梦余,叶玲,汪成林.白细胞介素-17及其在口腔疾病中的作用[J].国际口腔医学杂志,2015,42(6):728. [14] 袁萍,李淑慧,赵璐,等.炎症微环境下人牙周膜干细胞的生物学特性[J].中国组织工程研究,2016,20(6):898. -
点击查看大图
计量
- 文章访问数: 4927
- HTML全文浏览量: 1171
- PDF下载量: 18
- 被引次数: 0
下载:
