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2011 Vol. 36, No. 4
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2011, 36(4): 329-331.
Abstract:
Objective: To observe the effect of ω-3 polyunsaturated fatty acids (ω-3 PUFA) on nuclear factor (NF) -κB expression in the lung tissue of sepsis induced acute lung injury (ALI) rat model.Methods: Thirty experimental rats were randomly divided into three groups:healthy controls (A),sepsis group (B) and intervention group (C),ten in each.The sepsis ALI rat model of group B and C was established through cecal ligation perforation,and group C group nutritional support contains ω-3 PUFA through the jugular enous catheter.The expression of NF-κB in the lung tissue of three groups was detected by immunohistochemistry (ABC) and Western blot.Results: In group A,only a few scattered NF-κB nuclear positive cells were found;in group B,plenty of NF-κB nuclear positive cells were present in the airway mucous membrane,interstitial lung,alveolar space and endothelial cells (P<0.01);in group C,the quantity of NF-κB nuclear positive cells was higher than that in the control group,but decreased significantly than that in ALI group (P<0.01).Western blot results indicated that,the expression of NF-κB protein were exist in the three groups.Conclusions: ω-3 PUFA can decrease the protein expression of NF-κB in the lung tissue of sepsis induced ALI rat model.ω-3 PUFA could alleviate inflammation by inhibiting activation of NF-κB.
Objective: To observe the effect of ω-3 polyunsaturated fatty acids (ω-3 PUFA) on nuclear factor (NF) -κB expression in the lung tissue of sepsis induced acute lung injury (ALI) rat model.Methods: Thirty experimental rats were randomly divided into three groups:healthy controls (A),sepsis group (B) and intervention group (C),ten in each.The sepsis ALI rat model of group B and C was established through cecal ligation perforation,and group C group nutritional support contains ω-3 PUFA through the jugular enous catheter.The expression of NF-κB in the lung tissue of three groups was detected by immunohistochemistry (ABC) and Western blot.Results: In group A,only a few scattered NF-κB nuclear positive cells were found;in group B,plenty of NF-κB nuclear positive cells were present in the airway mucous membrane,interstitial lung,alveolar space and endothelial cells (P<0.01);in group C,the quantity of NF-κB nuclear positive cells was higher than that in the control group,but decreased significantly than that in ALI group (P<0.01).Western blot results indicated that,the expression of NF-κB protein were exist in the three groups.Conclusions: ω-3 PUFA can decrease the protein expression of NF-κB in the lung tissue of sepsis induced ALI rat model.ω-3 PUFA could alleviate inflammation by inhibiting activation of NF-κB.
2011, 36(4): 332-334.
Abstract:
Objective: To observe and evaluate the effect of curcumin on content of hydroxyproline in the epidural scar tissue of rats after laminectomy,and to explore its mechanism.Methods: Thirty-six SD rats with 0.3 cm×0.5 cm epidural exposed area after L1 laminectomy surgery were randomly divided into 3 groups.The control group (group A) received no treatment;the collagen sponge group (group B) and the curcumin collagen sponge group (group C) were respectively placed 0.5 cm×0.7 cm collagen sponge and collagen sponge absorbing curcumin dimethyl sulfoxide solution (0.25 g/ml) in the laminectomy defect.Four weeks later,the level of hydroxyproline in the scar tissue was determined,and the degree of peridural adhesion was generally evaluated according to the Rydell standard.Results: The content of hydroxyproline in group B and group C was lower than that in group A (P<0.05 and P<0.01).Conclusions: Curcumin can reduce epidural scar production and inhibit the formation of collagen fibers.
Objective: To observe and evaluate the effect of curcumin on content of hydroxyproline in the epidural scar tissue of rats after laminectomy,and to explore its mechanism.Methods: Thirty-six SD rats with 0.3 cm×0.5 cm epidural exposed area after L1 laminectomy surgery were randomly divided into 3 groups.The control group (group A) received no treatment;the collagen sponge group (group B) and the curcumin collagen sponge group (group C) were respectively placed 0.5 cm×0.7 cm collagen sponge and collagen sponge absorbing curcumin dimethyl sulfoxide solution (0.25 g/ml) in the laminectomy defect.Four weeks later,the level of hydroxyproline in the scar tissue was determined,and the degree of peridural adhesion was generally evaluated according to the Rydell standard.Results: The content of hydroxyproline in group B and group C was lower than that in group A (P<0.05 and P<0.01).Conclusions: Curcumin can reduce epidural scar production and inhibit the formation of collagen fibers.
2011, 36(4): 335-338.
Abstract:
Objective: To study the protective effect of Ginkgo biloba extract (EGb761) on cardiomyocyte after acute myocardial infarction (AMI) in rats.Methods: Thirty male Sprague-Dawley rats were randomly divided into sham group (group A),AMI group (group B),EGb761 group (group C),ten in each group.In group C,EGb 761 (20 mg/kg) was injected intraperitoneally,in group A and group B,normal saline (20 mg/kg) was injected intraperitoneally.All the liquid was injected once a day for 3 days.The animal model was established by ligating left anterior descending coronary artery on the third day.The operation in group A was similar to group B except for ligating the left anterior descending coronary artery.At the end of experiment,the levels of the superoxide dismutase (SOD),malondialdehyde (MDA),apoptotic index (AI),mitochondrial membrane potential and the expression of Cyt-c and caspase-9 were measured.Results: Compared with group B,the contents of MDA,AI,caspase-9 and cytoplasmic Cyt-c were significantly lower in group C (P<0.01).The level of SOD,the expression of mitochondrial Cyt-c and mitochondrial membrane potential were significantly higher in group C (P<0.01).Conclusions: EGb 761 can decrease apoptosis in ischemic myocardium after acute myocardial infarction.The mechanism is possibly that EGb 761 can decrease oxidative stress,protect mitochondrial functions and reduce the release of Cyt-c from mitochondria to cytoplasma.
Objective: To study the protective effect of Ginkgo biloba extract (EGb761) on cardiomyocyte after acute myocardial infarction (AMI) in rats.Methods: Thirty male Sprague-Dawley rats were randomly divided into sham group (group A),AMI group (group B),EGb761 group (group C),ten in each group.In group C,EGb 761 (20 mg/kg) was injected intraperitoneally,in group A and group B,normal saline (20 mg/kg) was injected intraperitoneally.All the liquid was injected once a day for 3 days.The animal model was established by ligating left anterior descending coronary artery on the third day.The operation in group A was similar to group B except for ligating the left anterior descending coronary artery.At the end of experiment,the levels of the superoxide dismutase (SOD),malondialdehyde (MDA),apoptotic index (AI),mitochondrial membrane potential and the expression of Cyt-c and caspase-9 were measured.Results: Compared with group B,the contents of MDA,AI,caspase-9 and cytoplasmic Cyt-c were significantly lower in group C (P<0.01).The level of SOD,the expression of mitochondrial Cyt-c and mitochondrial membrane potential were significantly higher in group C (P<0.01).Conclusions: EGb 761 can decrease apoptosis in ischemic myocardium after acute myocardial infarction.The mechanism is possibly that EGb 761 can decrease oxidative stress,protect mitochondrial functions and reduce the release of Cyt-c from mitochondria to cytoplasma.
2011, 36(4): 339-341.
Abstract:
Objective: To establish moderate to severe intracerebral hemorrhage models by injecting type Ⅳ collagenase and heparin into the caudate putamen nuclei of rats.Methods: A total of 66 SD rats were randomly divided into Ⅳ collagenase 0.4 U + heparin 4 U injection group (group A,12 rats),Ⅳ collagenase 0.6 U + heparin 4 U injection group (group,B 42 rats) and Ⅳ collagenase 0.8 U+heparin 4 U injection group (group C,12 rats).The neurological behavior scores of the rats in group A and group C were assessed at 24 and 72 hour after the injection,and those of group B were assessed at 4,12,24,48,72 hour,5 and 7days after the injection.The volume of hematoma and edema was detected by multimedia pathological imaging analysis system.Results: The scores of neurological behavior,the volume of hematoma and edema had obvious difference among the three groups (P<0.01).The hematoma in group A was small and diffused,the edema strip was narrow,and the neurological deficit was light compared with those of group B and C.However,the mortality after injection was 37% in group C,which was much higher than that in the other two groups.Conclusions: Intracerebral hemorrhage models can be established by injecting 0.6 U Ⅳ collagenase and 4 U heparin into the caudate putamen nuclei of rats.The models have obvious neurological deficits and a high persistence,which may be used for the study of intracerebral hemorrhage.
Objective: To establish moderate to severe intracerebral hemorrhage models by injecting type Ⅳ collagenase and heparin into the caudate putamen nuclei of rats.Methods: A total of 66 SD rats were randomly divided into Ⅳ collagenase 0.4 U + heparin 4 U injection group (group A,12 rats),Ⅳ collagenase 0.6 U + heparin 4 U injection group (group,B 42 rats) and Ⅳ collagenase 0.8 U+heparin 4 U injection group (group C,12 rats).The neurological behavior scores of the rats in group A and group C were assessed at 24 and 72 hour after the injection,and those of group B were assessed at 4,12,24,48,72 hour,5 and 7days after the injection.The volume of hematoma and edema was detected by multimedia pathological imaging analysis system.Results: The scores of neurological behavior,the volume of hematoma and edema had obvious difference among the three groups (P<0.01).The hematoma in group A was small and diffused,the edema strip was narrow,and the neurological deficit was light compared with those of group B and C.However,the mortality after injection was 37% in group C,which was much higher than that in the other two groups.Conclusions: Intracerebral hemorrhage models can be established by injecting 0.6 U Ⅳ collagenase and 4 U heparin into the caudate putamen nuclei of rats.The models have obvious neurological deficits and a high persistence,which may be used for the study of intracerebral hemorrhage.
2011, 36(4): 342-344.
Abstract:
Objective: To summarize the experience intreatment of phlegmasia cerulea dolens (PCD) and to explore the optimal therapy.Methods: The clinical data of 12 cases of PCD were retrospectively analyzed,11 cases were treated surgically,the surgical procedures included simple thrombectomy in 4 limbs,inferior vena cava filter placement+thrombectomy in 2 limbs,inferior vena cava filter placement +thrombectomy+left iliac vein balloon angioplasty in 5 limbs.Only one patient received anticoagulation and thrombolysis.Results: All surgery in 11 cases were sucessful,no severe postoperative complications occurred,all the patients were cured of their symptoms,there was pulmonary embolism,amputation or death.The pulsation of dorsal artery was found overnight,and the limb was almost normal after 8 days in anther patient receiving conventional treatment.Conclusions: Thrombectomy combined prompt and full dosage of anticoagulation is safe,effective,and economical for treatment of PCD.
Objective: To summarize the experience intreatment of phlegmasia cerulea dolens (PCD) and to explore the optimal therapy.Methods: The clinical data of 12 cases of PCD were retrospectively analyzed,11 cases were treated surgically,the surgical procedures included simple thrombectomy in 4 limbs,inferior vena cava filter placement+thrombectomy in 2 limbs,inferior vena cava filter placement +thrombectomy+left iliac vein balloon angioplasty in 5 limbs.Only one patient received anticoagulation and thrombolysis.Results: All surgery in 11 cases were sucessful,no severe postoperative complications occurred,all the patients were cured of their symptoms,there was pulmonary embolism,amputation or death.The pulsation of dorsal artery was found overnight,and the limb was almost normal after 8 days in anther patient receiving conventional treatment.Conclusions: Thrombectomy combined prompt and full dosage of anticoagulation is safe,effective,and economical for treatment of PCD.
2011, 36(4): 345-346.
Abstract:
Objective: To discuss the clinical features of non-hematological diseases with hematocytopenia and to avoid misdiagnosis and missed-diagnosis.Methods: The clinical manifestation,examination data and diagnosis of 108 patients with non-hematological diseases with hematocytopenia were analyzed retrospectively.Results: Of the 108 cases,infectious diseases ranked the first (28.7%),and the most commom infection was malaria.Twenty-one cases displayed hypersplenism,and 21 cases had connective tissue diseases,most of which were systemic lupus erythematosus.Metastatic carcinoma of the bone marrow was observed in 18 cases,hypothyroidism in 7 cases,hyperthyroidism in 5 cases and gastroenteric tumor in 5 cases.Conclusions: Infectious diseases,hematocytopenia,hypersplenism,connective tissue disease and metastatic carcinoma of the bone marrow are frequently observed in non-hematological diseases,which should arouse the clinicians' attention and help them make correct diagnosis.
Objective: To discuss the clinical features of non-hematological diseases with hematocytopenia and to avoid misdiagnosis and missed-diagnosis.Methods: The clinical manifestation,examination data and diagnosis of 108 patients with non-hematological diseases with hematocytopenia were analyzed retrospectively.Results: Of the 108 cases,infectious diseases ranked the first (28.7%),and the most commom infection was malaria.Twenty-one cases displayed hypersplenism,and 21 cases had connective tissue diseases,most of which were systemic lupus erythematosus.Metastatic carcinoma of the bone marrow was observed in 18 cases,hypothyroidism in 7 cases,hyperthyroidism in 5 cases and gastroenteric tumor in 5 cases.Conclusions: Infectious diseases,hematocytopenia,hypersplenism,connective tissue disease and metastatic carcinoma of the bone marrow are frequently observed in non-hematological diseases,which should arouse the clinicians' attention and help them make correct diagnosis.
2011, 36(4): 347-349,353.
Abstract:
Objective: To explore the clinicopathological features of the cervical acetowhite epithelium and its significance.Methods: Cone biopsy by colposcope was performed in seven hundred women who were positive results for naked eye visual inspection with acetic acid on the uterine cervix.The clinical and pathological data were reviewed.Results: One hundred and twenty-one cervical intraepithelial neoplasia (CIN),including 65 cases of CIN1,28 cases of CIN2 and 28 cases of CIN3,7 squamous cell carcinoma,471 inflammation,34 squamous metaplasia,64 hyperplasia and 3 normal mucosa were diagnosed by histopathology.Conclusions: Using pathological results from cervical biopsy at acetowhite epithelium areas under colposcope as the final diagnosis may correctly guide the screening,diagnosis and treatment for precancerous cervical lesions and carcinomas.
Objective: To explore the clinicopathological features of the cervical acetowhite epithelium and its significance.Methods: Cone biopsy by colposcope was performed in seven hundred women who were positive results for naked eye visual inspection with acetic acid on the uterine cervix.The clinical and pathological data were reviewed.Results: One hundred and twenty-one cervical intraepithelial neoplasia (CIN),including 65 cases of CIN1,28 cases of CIN2 and 28 cases of CIN3,7 squamous cell carcinoma,471 inflammation,34 squamous metaplasia,64 hyperplasia and 3 normal mucosa were diagnosed by histopathology.Conclusions: Using pathological results from cervical biopsy at acetowhite epithelium areas under colposcope as the final diagnosis may correctly guide the screening,diagnosis and treatment for precancerous cervical lesions and carcinomas.
2011, 36(4): 350-353.
Abstract:
Objective: To explore the expressions of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expressions of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens,including 60 cases of cervix carcinoma,30 cases of cervical intraepithelial neoplasia (CIN),and 30 cases of normal cervical epithelia.The expression changes of Skp2 and Ki67 proteins in the formation of cervical intraepithelial neoplasia and cervix carcinoma and the relationship between the clinical features and pathological features were analyzed.Results: The positive rates of Skp2 and Ki67 in normal cervical epithelia,CIN and cervix carcinoma were 13.3%,66.7%,71.7% and 16.7%,56.7%,83.3%,respectively;the positive rates of both in CIN and cervix carcinoma were notably higher than in normal cervical epithelia (P<0.01);and there had some relationship of Skp2 and Ki67 in the same cervical carcinoma tissues (P<0.05).Conclusions: Skp2 and Ki67 expressions may play an important role in the development and progression of cervical carcinoma;Skp2 and Ki67 could be used as markers for early diagnosis of cervix carcinoma.It can be helpful for increasing the ratio of early diagnosis of cervix carcinoma.
Objective: To explore the expressions of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expressions of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens,including 60 cases of cervix carcinoma,30 cases of cervical intraepithelial neoplasia (CIN),and 30 cases of normal cervical epithelia.The expression changes of Skp2 and Ki67 proteins in the formation of cervical intraepithelial neoplasia and cervix carcinoma and the relationship between the clinical features and pathological features were analyzed.Results: The positive rates of Skp2 and Ki67 in normal cervical epithelia,CIN and cervix carcinoma were 13.3%,66.7%,71.7% and 16.7%,56.7%,83.3%,respectively;the positive rates of both in CIN and cervix carcinoma were notably higher than in normal cervical epithelia (P<0.01);and there had some relationship of Skp2 and Ki67 in the same cervical carcinoma tissues (P<0.05).Conclusions: Skp2 and Ki67 expressions may play an important role in the development and progression of cervical carcinoma;Skp2 and Ki67 could be used as markers for early diagnosis of cervix carcinoma.It can be helpful for increasing the ratio of early diagnosis of cervix carcinoma.
2011, 36(4): 354-355,358.
Abstract:
Objective: To observe the clinical effect of multi-level limited decompression with microendoscopic disectomy through posterior approach on lumbar spinal stenosis.Methods: Eighteen patients with lumbar spinal stenosis were managed by multi-level limited decompression with microendoscopic disectomy.The preoperative Oswestry disability index (ODI) and visual analogue scale (VAS) were compared with the postoperative scores,and the clinical effects were reviewed and analyzed.Results: There was significant difference in preoperative ODI and VAS compared with the postoperative scores (P<0.01).The follow-up lasted from 8 to 39 months.The evaluation by Nakai standard revealed that the outcome was excellent in 11 cases,good in 3 cases,fair in 3 cases and poor in 1 case.The rate of good results was 77.78%.Conclusions: Multi-level limited decompression by microendoscopic disectomy through posterior approach has the advantages of fewer traumas,less blood loss and better clinical outcome in treatment of lumbar spinal stenosis.
Objective: To observe the clinical effect of multi-level limited decompression with microendoscopic disectomy through posterior approach on lumbar spinal stenosis.Methods: Eighteen patients with lumbar spinal stenosis were managed by multi-level limited decompression with microendoscopic disectomy.The preoperative Oswestry disability index (ODI) and visual analogue scale (VAS) were compared with the postoperative scores,and the clinical effects were reviewed and analyzed.Results: There was significant difference in preoperative ODI and VAS compared with the postoperative scores (P<0.01).The follow-up lasted from 8 to 39 months.The evaluation by Nakai standard revealed that the outcome was excellent in 11 cases,good in 3 cases,fair in 3 cases and poor in 1 case.The rate of good results was 77.78%.Conclusions: Multi-level limited decompression by microendoscopic disectomy through posterior approach has the advantages of fewer traumas,less blood loss and better clinical outcome in treatment of lumbar spinal stenosis.
2011, 36(4): 356-358.
Abstract:
Objective: To compare the effects of two kinds of β2-receptor agonists and different inhalation devices on the result of bronchodilatation testing.Methods: One hundred patients with bronchial asthma were divided into 3 groups:30 patients in group A inhaled terbutaline aerosol via PMDI,30 patients in group B inhaled salbutamol aerosol via PMDI,and 40 patients in group C inhaled terbutaline aerosol by spacer.The pulmonary function was checked after 15 minutes;the improving rate,the increased absolute value and the positive rate of bronchodilatation were calculated.Results: As for the improving rate,the absolute value and the positive rate of FEV1,no differences were detected in Group A and Group B (P>0.05);in Group C the above three rates were averagely higher than those in Group A and B,and the difference was significant (P<0.01).Conclusions: The comparative study shows that the effects of two short acting β2-receptor agonists are similar to salbutamol in bronchodilatation testing;the effect of inhaling by spacer is better than by PMDI,as it can increase the absorption factor,enhance the positive rate of bronchodilatation and reduce the missed diagnosis of bronchial asthma.
Objective: To compare the effects of two kinds of β2-receptor agonists and different inhalation devices on the result of bronchodilatation testing.Methods: One hundred patients with bronchial asthma were divided into 3 groups:30 patients in group A inhaled terbutaline aerosol via PMDI,30 patients in group B inhaled salbutamol aerosol via PMDI,and 40 patients in group C inhaled terbutaline aerosol by spacer.The pulmonary function was checked after 15 minutes;the improving rate,the increased absolute value and the positive rate of bronchodilatation were calculated.Results: As for the improving rate,the absolute value and the positive rate of FEV1,no differences were detected in Group A and Group B (P>0.05);in Group C the above three rates were averagely higher than those in Group A and B,and the difference was significant (P<0.01).Conclusions: The comparative study shows that the effects of two short acting β2-receptor agonists are similar to salbutamol in bronchodilatation testing;the effect of inhaling by spacer is better than by PMDI,as it can increase the absorption factor,enhance the positive rate of bronchodilatation and reduce the missed diagnosis of bronchial asthma.
2011, 36(4): 359-360.
Abstract:
Objective: To assess the effect of bi-polar electrocoagulation under nosal endoscope in treatment of intractable epistaxis in the elderly.Methods: Thirty-eight elderly patients with intractable epistaxis were checked by nosa endoscope and performed bi-polar electrocoagulation once the hemorrhagic focus was detected.Results: Hemorrhagic focus was detected by nosal endoscope in 37 cases and no definite hemorrhagic focus was found in 1 case.Thirty-six cases were cured on the first treatment,and 2 cases with hypertension that still had slight bleeding after treatment were cured after the blood pressure was controlled.All the cases were followed up for 3 months;no recurrence or complication were observed.Conclusions: The nasal endoscope can locate the epistaxis focus precisely;bi-polar electrocoagulation is an effective means for treatment of intractable epistaxis in the elderly.
Objective: To assess the effect of bi-polar electrocoagulation under nosal endoscope in treatment of intractable epistaxis in the elderly.Methods: Thirty-eight elderly patients with intractable epistaxis were checked by nosa endoscope and performed bi-polar electrocoagulation once the hemorrhagic focus was detected.Results: Hemorrhagic focus was detected by nosal endoscope in 37 cases and no definite hemorrhagic focus was found in 1 case.Thirty-six cases were cured on the first treatment,and 2 cases with hypertension that still had slight bleeding after treatment were cured after the blood pressure was controlled.All the cases were followed up for 3 months;no recurrence or complication were observed.Conclusions: The nasal endoscope can locate the epistaxis focus precisely;bi-polar electrocoagulation is an effective means for treatment of intractable epistaxis in the elderly.
2011, 36(4): 361-362,365.
Abstract:
Objective: To investigate the clinical features and treatment of young patients with primary liver cancer (PLC).Methods: A total of 80 cases of PLC were divided into 2 groups,young group (age<40 years),24 cases;non-young group (age ≥ 40 years),56 cases.The clinical symptoms,clinicopathologic features,clinical conditions of liver and the incidence of postoperative complications in the two groups were comparatively analyzed.Results: The cases in young group have less specific clinical manifestations than the cases in non-young group (P<0.05-P<0.01);cholangiocarcinoma in the young group are less than that in non-young group (P<0.05),young group has a better liver fuction than that of non young group (P<0.01).Postoperative complications rate in young group is lower than in non-young group (P<0.05).Conclusions: Occult liver cancer onset,low early diagnosis and high operation tolerance occur in young PLC patients;surgery-predominant comprehensive therapy should be performed for young PLC patients to improve outcome.Low incidence of postoperative complications were also noted in young PLC patients.
Objective: To investigate the clinical features and treatment of young patients with primary liver cancer (PLC).Methods: A total of 80 cases of PLC were divided into 2 groups,young group (age<40 years),24 cases;non-young group (age ≥ 40 years),56 cases.The clinical symptoms,clinicopathologic features,clinical conditions of liver and the incidence of postoperative complications in the two groups were comparatively analyzed.Results: The cases in young group have less specific clinical manifestations than the cases in non-young group (P<0.05-P<0.01);cholangiocarcinoma in the young group are less than that in non-young group (P<0.05),young group has a better liver fuction than that of non young group (P<0.01).Postoperative complications rate in young group is lower than in non-young group (P<0.05).Conclusions: Occult liver cancer onset,low early diagnosis and high operation tolerance occur in young PLC patients;surgery-predominant comprehensive therapy should be performed for young PLC patients to improve outcome.Low incidence of postoperative complications were also noted in young PLC patients.
2011, 36(4): 363-365.
Abstract:
Objective: To compare the advantage and disadvantage of umbilical cord clip ligation and valve core ligation.Methods: The neonates who were randomly sampled including 202 cases of umbilical cord clip and 119 cases of valve core were observed.Results: The cure time of valve core group was shorter than the time of umbilical cord clip group obviously (P<0.05),and no umbilical cord complication happening.Conclusions: The value core ligation is better than umbilical cord clip ligation obviously,and it reduces the occurrence of umbilical inflammation,as well as convenient,effective and economical.
Objective: To compare the advantage and disadvantage of umbilical cord clip ligation and valve core ligation.Methods: The neonates who were randomly sampled including 202 cases of umbilical cord clip and 119 cases of valve core were observed.Results: The cure time of valve core group was shorter than the time of umbilical cord clip group obviously (P<0.05),and no umbilical cord complication happening.Conclusions: The value core ligation is better than umbilical cord clip ligation obviously,and it reduces the occurrence of umbilical inflammation,as well as convenient,effective and economical.
2011, 36(4): 366-367.
Abstract:
Objective: To explore the surgical approach,indications and perioperative management of simultaneous bilateral neck dissection.Methods: Among 38 patients with simultaneous bilateral neck dissection,37 cases were treated by simultaneous bilateral neck dissection or selective neck dissection,only 1 by unilateral radical neck dissection and contralateral functional neck dissection.Results: There was no operative death in this group.Postoperative complications included:1 wound bleeding;2 unilateral chylous fistulas which were recovery by way of expectant treatment with vacuum suction;1 experienced tracheotomy on 3rd day after the operation of bilateral thyroid cancer,on half a year after the tube removed and left hospital who experienced tracheotomy because of difficulty breathing and permanent reserved the tube;2 experienced pharyngeal fistula,among of 2,1 was recovery after expectant treatment and 1 recovery after reconstructed with pedicle pectoralis major myocutaneous flap.The lymph node positive number is from 0 to 12,average 4/cases;21 cases bilateral neck lymph node were positive,11 unilateral lymph node positive and contralateral negative,6 bilateral lymph node negative.Conclusions: If the operation indication is restrictedly controlled,adequate perioperative preparation and timely,correct perioperative management.Simultaneous bilateral neck dissection is safe,eliminating pain of two-stage operation,retrenching payment for medical care.
Objective: To explore the surgical approach,indications and perioperative management of simultaneous bilateral neck dissection.Methods: Among 38 patients with simultaneous bilateral neck dissection,37 cases were treated by simultaneous bilateral neck dissection or selective neck dissection,only 1 by unilateral radical neck dissection and contralateral functional neck dissection.Results: There was no operative death in this group.Postoperative complications included:1 wound bleeding;2 unilateral chylous fistulas which were recovery by way of expectant treatment with vacuum suction;1 experienced tracheotomy on 3rd day after the operation of bilateral thyroid cancer,on half a year after the tube removed and left hospital who experienced tracheotomy because of difficulty breathing and permanent reserved the tube;2 experienced pharyngeal fistula,among of 2,1 was recovery after expectant treatment and 1 recovery after reconstructed with pedicle pectoralis major myocutaneous flap.The lymph node positive number is from 0 to 12,average 4/cases;21 cases bilateral neck lymph node were positive,11 unilateral lymph node positive and contralateral negative,6 bilateral lymph node negative.Conclusions: If the operation indication is restrictedly controlled,adequate perioperative preparation and timely,correct perioperative management.Simultaneous bilateral neck dissection is safe,eliminating pain of two-stage operation,retrenching payment for medical care.
2011, 36(4): 368-369.
Abstract:
Objective: To explore the clinical characteristics and treatment of air leak in neonates.Methods: Thirty cases of clinical manifestation,classification,treatment and prognosis of air leak in neonates were analyzed retrospectively.Results: Dyspnea,cyanosis were the main clinical symptoms of air leak in neonates,pneumothorax was the most common.Conclusions: Clinical feature of air leak in neonates is characteristic,correct diagnosis and reasonable treatment are the key to increase cure rate and discrease mortality.
Objective: To explore the clinical characteristics and treatment of air leak in neonates.Methods: Thirty cases of clinical manifestation,classification,treatment and prognosis of air leak in neonates were analyzed retrospectively.Results: Dyspnea,cyanosis were the main clinical symptoms of air leak in neonates,pneumothorax was the most common.Conclusions: Clinical feature of air leak in neonates is characteristic,correct diagnosis and reasonable treatment are the key to increase cure rate and discrease mortality.
2011, 36(4): 370-373.
Abstract:
Objective: To study the clinicopathologic characteristics,diagnosis and prognosis of lung adenocarcinoma with a micropapillary pattern (MPP).Methods: Four cases of lung adenocarinoma with MPP were retrospectively analyzed.The pathological features and the immnunotype were observed by light microscopy,and the literature was reviewed.Results: The clinical manifestations of lung adenocarcinoma with MPP were cough,expectoration and bloody sputum.Imaging findings demonstrated masses in the lung.Microscopically,the tumors consisted of variable proportion of corpora mammillaria cell clusters devoid of a fibrovascular core.By immunohistochemical staining,the tumor cells showed positive epithelial membrane antigen,E-cadherin,thyroid transcription factor-1 and cytokeratin 7;antigen (Ki-67) was highly expressed.The expressions of cytokeratin 20 and estrogen receptor were negative.The follow-up was two years on the average.Two of the cases developed hydrothorax and ascites six months after the operation,and the other two cases survived up to now with no distant metastasis.Conclusions: The content of MPP suggests invasion and metastasis of lung adenocarcinoma with MPP,which is an important factor influencing the prognosis.
Objective: To study the clinicopathologic characteristics,diagnosis and prognosis of lung adenocarcinoma with a micropapillary pattern (MPP).Methods: Four cases of lung adenocarinoma with MPP were retrospectively analyzed.The pathological features and the immnunotype were observed by light microscopy,and the literature was reviewed.Results: The clinical manifestations of lung adenocarcinoma with MPP were cough,expectoration and bloody sputum.Imaging findings demonstrated masses in the lung.Microscopically,the tumors consisted of variable proportion of corpora mammillaria cell clusters devoid of a fibrovascular core.By immunohistochemical staining,the tumor cells showed positive epithelial membrane antigen,E-cadherin,thyroid transcription factor-1 and cytokeratin 7;antigen (Ki-67) was highly expressed.The expressions of cytokeratin 20 and estrogen receptor were negative.The follow-up was two years on the average.Two of the cases developed hydrothorax and ascites six months after the operation,and the other two cases survived up to now with no distant metastasis.Conclusions: The content of MPP suggests invasion and metastasis of lung adenocarcinoma with MPP,which is an important factor influencing the prognosis.
2011, 36(4): 374-376.
Abstract:
Objective: To explore the operating approach and clinical efficacy of transthoracic approach for surgical treatment in children with esophageal hiatal hernia (HH).Methods: Fourteen children with HH were treated by operative repair through the left thoracical route and Belsey's antireflux surgery.Three of which were sliding hiatus hernia (typeⅠ),one of which was paraesophageal hernia (typeⅡ),and another 10 children were mixed hernia (type Ⅲ).Results: The procedures were successfully completed in all patients and had good outcome.The operation time was 130-180 min,length of hospitalisation was 15-31 days,and the extubation time was 3-11 days after operation.All patients were followed up from 3 months to 2 years,the preoperative symptoms were disappeared.The children had gained weight and height,and were healthy during the follow-up.Conclusions: The children in Type Ⅰwhose symptoms cannot be controlled by drug measures and the children in TypeⅡ,Ⅲ should do early surgical treatment.Transthoracic approach operative repair of HH and Belsey's antireflux surgery is a kind of technique with good operative field,small concealing incision,easy to operate and repair,and low dysphagia incidence.It is an effective and practical approach for the surgical treatment of HH.
Objective: To explore the operating approach and clinical efficacy of transthoracic approach for surgical treatment in children with esophageal hiatal hernia (HH).Methods: Fourteen children with HH were treated by operative repair through the left thoracical route and Belsey's antireflux surgery.Three of which were sliding hiatus hernia (typeⅠ),one of which was paraesophageal hernia (typeⅡ),and another 10 children were mixed hernia (type Ⅲ).Results: The procedures were successfully completed in all patients and had good outcome.The operation time was 130-180 min,length of hospitalisation was 15-31 days,and the extubation time was 3-11 days after operation.All patients were followed up from 3 months to 2 years,the preoperative symptoms were disappeared.The children had gained weight and height,and were healthy during the follow-up.Conclusions: The children in Type Ⅰwhose symptoms cannot be controlled by drug measures and the children in TypeⅡ,Ⅲ should do early surgical treatment.Transthoracic approach operative repair of HH and Belsey's antireflux surgery is a kind of technique with good operative field,small concealing incision,easy to operate and repair,and low dysphagia incidence.It is an effective and practical approach for the surgical treatment of HH.
2011, 36(4): 376-378.
Abstract:
Objective: To investigate the clinical value of endovascular coil embolism of intracranial aneurysm and discuss the points for attention during the procedure.Methods: Twenty patients with intracranial aneurysms were undergone the embolism with intravascular coils.In the study,2 cases who had wide-neck aneurysms were treatment with neuroform stent placement.All cases were diagnosed by digital subtraction angiography (DSA) before operation.Results: Nineteen cases were successfully for the therapeutic processes,while 1 was ruptured during operation and died within 4 days;1 was complicated the blockage in the right PCA after operation 3 days and died in the next two days.Fifteen cases were followed up for 6-8 months by DSA,the aneurysms were embolizated completely and the parent artery was patency.Conclusions: Endovascular coil embolization of intracranial aneurysms is a safe and effective method.Several techniques combination will improve future outcomes according to the shape of aneurysms.
Objective: To investigate the clinical value of endovascular coil embolism of intracranial aneurysm and discuss the points for attention during the procedure.Methods: Twenty patients with intracranial aneurysms were undergone the embolism with intravascular coils.In the study,2 cases who had wide-neck aneurysms were treatment with neuroform stent placement.All cases were diagnosed by digital subtraction angiography (DSA) before operation.Results: Nineteen cases were successfully for the therapeutic processes,while 1 was ruptured during operation and died within 4 days;1 was complicated the blockage in the right PCA after operation 3 days and died in the next two days.Fifteen cases were followed up for 6-8 months by DSA,the aneurysms were embolizated completely and the parent artery was patency.Conclusions: Endovascular coil embolization of intracranial aneurysms is a safe and effective method.Several techniques combination will improve future outcomes according to the shape of aneurysms.
2011, 36(4): 379-381.
Abstract:
Objective: To explore the prevention and treatment of rehemorrhage after surgery for hypertensive intracerebral hemorrhage.Methods: The clinical data of 61 cases of rehaemorrhage after operation for hypertensive intracerebral hemorrhage were analyzed retrospectively.Results: The incidence of postoperative rehaemorrhage was 13.3%.The main clinical manifestations were aggravated disturbance of consciousness,altered pupils and uncontrolled blood pressure.Seventy point five percent of the rehemorrhage occurred whinin 24 hours after the operation.Conclusions: The essential factors to prevent rehemorrhage are controlling bleeding properly during operation and keeping stable blood pressure after operation.Prompt diagnosis and surgery may save the patients' life and enhance their quality of life.
Objective: To explore the prevention and treatment of rehemorrhage after surgery for hypertensive intracerebral hemorrhage.Methods: The clinical data of 61 cases of rehaemorrhage after operation for hypertensive intracerebral hemorrhage were analyzed retrospectively.Results: The incidence of postoperative rehaemorrhage was 13.3%.The main clinical manifestations were aggravated disturbance of consciousness,altered pupils and uncontrolled blood pressure.Seventy point five percent of the rehemorrhage occurred whinin 24 hours after the operation.Conclusions: The essential factors to prevent rehemorrhage are controlling bleeding properly during operation and keeping stable blood pressure after operation.Prompt diagnosis and surgery may save the patients' life and enhance their quality of life.
2011, 36(4): 381-382.
Abstract:
Objective: To observe the effect of dual-tube continuous negative pressure drainage on patients receiving radical mastectomy.Methods: Forty-three patients with breast cancer underwent radical mastectomy,and the dual-tube continuous negative pressure drainage was applied.Subcutaneous fluid collection and skin flap necrosis were observed after the operation.Results: Primary healing was reached in 35 cases;subcutaneous fluid collection was detected in 5 cases,3 of which were in the axilla and 2 in the parasternal;skin flap necrosis occurred in 3 cases,which was mainly in the middle edge of the incision;2 cases suffered from both fluid collection and skin flap necrosis.Conclusions: After radical mastectomy,dual-tube continuous negative pressure drainage can reduce the subcutaneous fluid collection and skin flap necrosis.
Objective: To observe the effect of dual-tube continuous negative pressure drainage on patients receiving radical mastectomy.Methods: Forty-three patients with breast cancer underwent radical mastectomy,and the dual-tube continuous negative pressure drainage was applied.Subcutaneous fluid collection and skin flap necrosis were observed after the operation.Results: Primary healing was reached in 35 cases;subcutaneous fluid collection was detected in 5 cases,3 of which were in the axilla and 2 in the parasternal;skin flap necrosis occurred in 3 cases,which was mainly in the middle edge of the incision;2 cases suffered from both fluid collection and skin flap necrosis.Conclusions: After radical mastectomy,dual-tube continuous negative pressure drainage can reduce the subcutaneous fluid collection and skin flap necrosis.
2011, 36(4): 383-385.
Abstract:
Objective: To investigate the clinical effect of percutaneous kyphoplasty (PKP) in treatment of osteoporotic vertebral compression fractures,and the prevention of the complications.Methods: PKP was performed under C-arm X-ray in 11 cases of osteoporotic vertebral compression fractures.The visual-analogue scale,anterior vertebral height and Cobb angle were surveyed and analyzed before and after the operation.Results: The operation was successful in all the 11 cases.The visual-analogue scale,vertebral height and Cobb angle were restored after the operation.Bone cement leakage occurred in 1 case during the operation,but no pulmonary embolism or oppression to the spine or nerve was observed;one suffered adjacent vertebral fracture after the operation;no infection or rib fracture occurred.Conclusions: Percutaneous kyphoplasty is safe and effective for treatment of osteoporotic vertebral compression fractures,which may reduce the pain,restore the vertebral height and rectify the spinal kyphosis with little surgical trauma.
Objective: To investigate the clinical effect of percutaneous kyphoplasty (PKP) in treatment of osteoporotic vertebral compression fractures,and the prevention of the complications.Methods: PKP was performed under C-arm X-ray in 11 cases of osteoporotic vertebral compression fractures.The visual-analogue scale,anterior vertebral height and Cobb angle were surveyed and analyzed before and after the operation.Results: The operation was successful in all the 11 cases.The visual-analogue scale,vertebral height and Cobb angle were restored after the operation.Bone cement leakage occurred in 1 case during the operation,but no pulmonary embolism or oppression to the spine or nerve was observed;one suffered adjacent vertebral fracture after the operation;no infection or rib fracture occurred.Conclusions: Percutaneous kyphoplasty is safe and effective for treatment of osteoporotic vertebral compression fractures,which may reduce the pain,restore the vertebral height and rectify the spinal kyphosis with little surgical trauma.
2011, 36(4): 387-389.
Abstract:
Objective: To observe the clinical characteristics of chronic hepatitis B patients with hepatitis E overlap-infection,and the influence of hepatitis E virus on patients with chronic hepatitis B.Methods: The clinical features of 40 patients with chronic hepatitis B overlapped with hepatitis E super infection and 40 patients with pure chronic hepatitis B infection were analyzed and compared.Results: The total bilirubin,alanin amino transferase,the aspartic acid amino transferase,the zymoplasm original activity and the blood albumin of the two groups differed significantly (P<0.05-P<0.01);the negative rate of HBeAg and the positive rate of HBV-DNA of the super infection group were lower than those of the control group (P<0.05).Conclusions: The chronic hepatitis B patients with hepatitis E overlap infection may resulted in acute aggravation and critical illness,but hepatitis E virus has certain inhibitory effect on the duplication of hepatitis B virus.
Objective: To observe the clinical characteristics of chronic hepatitis B patients with hepatitis E overlap-infection,and the influence of hepatitis E virus on patients with chronic hepatitis B.Methods: The clinical features of 40 patients with chronic hepatitis B overlapped with hepatitis E super infection and 40 patients with pure chronic hepatitis B infection were analyzed and compared.Results: The total bilirubin,alanin amino transferase,the aspartic acid amino transferase,the zymoplasm original activity and the blood albumin of the two groups differed significantly (P<0.05-P<0.01);the negative rate of HBeAg and the positive rate of HBV-DNA of the super infection group were lower than those of the control group (P<0.05).Conclusions: The chronic hepatitis B patients with hepatitis E overlap infection may resulted in acute aggravation and critical illness,but hepatitis E virus has certain inhibitory effect on the duplication of hepatitis B virus.
2011, 36(4): 395-397.
Abstract:
Objective: To evaluate the value of uterine artery embolization in treating postpartum hemorrhage.Methods: Fifteen cases with postpartum hematorrhea were treated by Seldinger catheterization of uterine arteries,and the uterine arteries were embolized super selectively by gelatin sponge after the hemorrhagic site were found by digital subtraction angiography (DSA).Some bleeding patients were also operated by micro-wheel embolism.Results: Uterine artery angiography showed that uterine artery had been embolized and no extravasation of contrast agent.The hemorrhage came from one side or double sides of uterine artery as diffused or focal uterine cavity bleeding or branch bleeding of uterinecavity or significantly distorted uterine artery.DSA angiography showed that the bleeding of 13 cases were ceased completely after embolism while the others were decreased obviously and gradually ceased within one week after drug treatment.Conclusions: The method of using the uterine artery embolization to treat the postpartum hematorrhea has many advantages which stopping bleeding quickly,effective,suffering lightly with few complications.
Objective: To evaluate the value of uterine artery embolization in treating postpartum hemorrhage.Methods: Fifteen cases with postpartum hematorrhea were treated by Seldinger catheterization of uterine arteries,and the uterine arteries were embolized super selectively by gelatin sponge after the hemorrhagic site were found by digital subtraction angiography (DSA).Some bleeding patients were also operated by micro-wheel embolism.Results: Uterine artery angiography showed that uterine artery had been embolized and no extravasation of contrast agent.The hemorrhage came from one side or double sides of uterine artery as diffused or focal uterine cavity bleeding or branch bleeding of uterinecavity or significantly distorted uterine artery.DSA angiography showed that the bleeding of 13 cases were ceased completely after embolism while the others were decreased obviously and gradually ceased within one week after drug treatment.Conclusions: The method of using the uterine artery embolization to treat the postpartum hematorrhea has many advantages which stopping bleeding quickly,effective,suffering lightly with few complications.
2011, 36(4): 398-400,404.
Abstract:
Objective: To compare real-time elastography and transvaginal ultrasound in diagnosis of cervical occupied lesions.Methods: Elastography screening was performed on 109 cervical occupied lesions in 65 patients,and the findings were classified into 5 grades;transvaginal ultrasoungraphy was used to detect the tumor size,shape,state,border,internal echo,calcification and the rear echo changes;the results by the two methods were compared.Results: The sensitivity,specificity and accuracy were 85.71%,82.11% and 82.57%,respectively by transvaginal ultrasoungraphy,while they were 100.00%,63.16% and 67.89% in cross section,and 100.00%,58.95% and 64.22% in longitudina section,respectively by elastography.Statistical results showed there was significant difference for elastography and pathological diagnosis (P<0.01).Transvaginal ultrasound in conjunction with real-time elastography in longitudinal section and cross section were 85.71%,93.68%,92.66% and 85.71%,92.63%,91.74%,respectively,statistical results showed there was no significant difference for elastography and pathological diagnosis (P>0.05).The sensitivity,specifity and the accuracy of real-time elastography and transvaginal ultrasound and transvaginal ultrasound in conjunction with real-time elastography for cervical occupide lesions were statistically significant (P<0.01),there was no significant eifference between cross-sectional and longitudinal-sectional (P>0.05).Conclusions: Elastosonography may provide some useful information for diagnosis of cervical occupied lesions,but findings by transvaginal ultrasound are still indispensable for final diagnosis.
Objective: To compare real-time elastography and transvaginal ultrasound in diagnosis of cervical occupied lesions.Methods: Elastography screening was performed on 109 cervical occupied lesions in 65 patients,and the findings were classified into 5 grades;transvaginal ultrasoungraphy was used to detect the tumor size,shape,state,border,internal echo,calcification and the rear echo changes;the results by the two methods were compared.Results: The sensitivity,specificity and accuracy were 85.71%,82.11% and 82.57%,respectively by transvaginal ultrasoungraphy,while they were 100.00%,63.16% and 67.89% in cross section,and 100.00%,58.95% and 64.22% in longitudina section,respectively by elastography.Statistical results showed there was significant difference for elastography and pathological diagnosis (P<0.01).Transvaginal ultrasound in conjunction with real-time elastography in longitudinal section and cross section were 85.71%,93.68%,92.66% and 85.71%,92.63%,91.74%,respectively,statistical results showed there was no significant difference for elastography and pathological diagnosis (P>0.05).The sensitivity,specifity and the accuracy of real-time elastography and transvaginal ultrasound and transvaginal ultrasound in conjunction with real-time elastography for cervical occupide lesions were statistically significant (P<0.01),there was no significant eifference between cross-sectional and longitudinal-sectional (P>0.05).Conclusions: Elastosonography may provide some useful information for diagnosis of cervical occupied lesions,but findings by transvaginal ultrasound are still indispensable for final diagnosis.
2011, 36(4): 401-404.
Abstract:
Objective: To explore the value of high frequency ultrasonography (HFU) and color Doppler flow imaging (CDFI) in diagnozing the breast tumor.Methods: A total of 171 patients were diagnosed by HFU and CDFI.Two-dimensional ultrasound was used to observe the size,margin and blood vessel distribution of the tumor;color Doppler was adopted to measure the degree of the blood flow signal,the peak systolic velocity and the resistance index.The results were compared with those by pathological examination after operation.Results: Compared with the pathological results,the accuracy of preoperative HFU reached 95.5% (71/82 benign and 85/89 malignant) in diagnosing the breast tumor.The misdiagnosis rate was 7.3% (6/82) and 4.5% (4/82) in the benign and malignant breast tumor,respectively.Benign and malignant tumors had evident discrepancy at the border,shape,internal echo,side echo,rear echo,blood vessel distribution and hemodynamics (P<0.01).Conclusions: HFU and CDFI can determine the size,number and location of the breast tumor.CDFI may evaluate the 2D images and hemodynamics parameters,which are of great value in making correct diagnosis of benign or malignant breast tumors.
Objective: To explore the value of high frequency ultrasonography (HFU) and color Doppler flow imaging (CDFI) in diagnozing the breast tumor.Methods: A total of 171 patients were diagnosed by HFU and CDFI.Two-dimensional ultrasound was used to observe the size,margin and blood vessel distribution of the tumor;color Doppler was adopted to measure the degree of the blood flow signal,the peak systolic velocity and the resistance index.The results were compared with those by pathological examination after operation.Results: Compared with the pathological results,the accuracy of preoperative HFU reached 95.5% (71/82 benign and 85/89 malignant) in diagnosing the breast tumor.The misdiagnosis rate was 7.3% (6/82) and 4.5% (4/82) in the benign and malignant breast tumor,respectively.Benign and malignant tumors had evident discrepancy at the border,shape,internal echo,side echo,rear echo,blood vessel distribution and hemodynamics (P<0.01).Conclusions: HFU and CDFI can determine the size,number and location of the breast tumor.CDFI may evaluate the 2D images and hemodynamics parameters,which are of great value in making correct diagnosis of benign or malignant breast tumors.
2011, 36(4): 405-406,409.
Abstract:
Objective: To investigate the trend of hepatitis B virus (HBV) infection in students enrolled in Bengbu Medical College in 2009 in order to provide scientific evidence for preventing and controlling HBV happening.Methods: Hepatitis B surface antigen (HBsAg),alanine aminotransferase (ALT) and total bilirubin (TBIL) levels of fasting blood plasma form 3120 students enrolled in Bengbu Medical College in 2009 were detected by enzyme-linked immunoadsordent assay,improved Reitman method and diazo-reaction method respectively.Results: In 3120 freshmen,there were 99 students who determined with positive HBsAg expression,the HBsAg infection rate was 3.17%;but there was no statistical difference (P>0.05) between the rate of male freshmen HBsAg infection (3.77%) and female freshmen HBsAg infection (2.82%).The abnormal rate of ALT and TBIL concentrations in male freshmen had statistical difference (P<0.01) compared with their abnormal rate of female freshmen,but there was no statistical difference (P>0.05) between the rate of HBsAg infection in freshmen who detected with abnormal ALT and others who detected with abnormal TBIL.Conclusions: The rate of HBsAg infection in the freshmen of our college is much lower than that of the social crowd,and it is necessary to strengthen management of students who carried hepatitis B virus,inoculate hepatitis B vaccine for susceptible population,and prevent the spread of hepatitis B virus in college.
Objective: To investigate the trend of hepatitis B virus (HBV) infection in students enrolled in Bengbu Medical College in 2009 in order to provide scientific evidence for preventing and controlling HBV happening.Methods: Hepatitis B surface antigen (HBsAg),alanine aminotransferase (ALT) and total bilirubin (TBIL) levels of fasting blood plasma form 3120 students enrolled in Bengbu Medical College in 2009 were detected by enzyme-linked immunoadsordent assay,improved Reitman method and diazo-reaction method respectively.Results: In 3120 freshmen,there were 99 students who determined with positive HBsAg expression,the HBsAg infection rate was 3.17%;but there was no statistical difference (P>0.05) between the rate of male freshmen HBsAg infection (3.77%) and female freshmen HBsAg infection (2.82%).The abnormal rate of ALT and TBIL concentrations in male freshmen had statistical difference (P<0.01) compared with their abnormal rate of female freshmen,but there was no statistical difference (P>0.05) between the rate of HBsAg infection in freshmen who detected with abnormal ALT and others who detected with abnormal TBIL.Conclusions: The rate of HBsAg infection in the freshmen of our college is much lower than that of the social crowd,and it is necessary to strengthen management of students who carried hepatitis B virus,inoculate hepatitis B vaccine for susceptible population,and prevent the spread of hepatitis B virus in college.
2011, 36(4): 407-409.
Abstract:
Objective: To study the clinical value of the changes of D-dimer (D-D),prothrombin time (PT),activated partial thrombopastin time (APTT),thrombin time (TT) and fibrinogen (FIB) in women during normal pregnancy and 3 days after delivery.Methods: The D-D,PT,APTT,FIB and TT of 80 healthy women (control group),240 normal pregnant women who were divided into 3 groups in accordance to the gestational weeks,and 80 three-day-postpartum women were determined using the hemagglutinin analyzer.Results: The PT in three-day-postpartum women was higher than the other groups (P<0.05-P<0.01),but PT in the prepregnancy,mid-pregnancy and late-pregnancy group were higher than the control group (P<0.01);the FIB,APTT and D-D were statistically different in the mid-pregnancy group and the late-pregnancy group compared with those in other groups (P<0.05-P<0.01);the TT in the late-pregnancy group was significantly lower than the control group and the three-day-postpartum women (P<0.05).Conclusions: Normal pregnant women are in a hypercoagulable state which is resumed about three days after delivery.Routine coagulation tests can be of great significance in preventing thrombosis in pregnant women.
Objective: To study the clinical value of the changes of D-dimer (D-D),prothrombin time (PT),activated partial thrombopastin time (APTT),thrombin time (TT) and fibrinogen (FIB) in women during normal pregnancy and 3 days after delivery.Methods: The D-D,PT,APTT,FIB and TT of 80 healthy women (control group),240 normal pregnant women who were divided into 3 groups in accordance to the gestational weeks,and 80 three-day-postpartum women were determined using the hemagglutinin analyzer.Results: The PT in three-day-postpartum women was higher than the other groups (P<0.05-P<0.01),but PT in the prepregnancy,mid-pregnancy and late-pregnancy group were higher than the control group (P<0.01);the FIB,APTT and D-D were statistically different in the mid-pregnancy group and the late-pregnancy group compared with those in other groups (P<0.05-P<0.01);the TT in the late-pregnancy group was significantly lower than the control group and the three-day-postpartum women (P<0.05).Conclusions: Normal pregnant women are in a hypercoagulable state which is resumed about three days after delivery.Routine coagulation tests can be of great significance in preventing thrombosis in pregnant women.
2011, 36(4): 410-412.
Abstract:
Objective: To explore the significance of the changes of blood coagulation index in patients with malignant blood system diseases.Methods: The difference of the blood coagulation index in 135 patients with malignant neoplastic hematologic disorder was analyzed retrospectively,and the changes of the blood coagulation index in patients with acute leukemia (AL),chronic leukemia (CL),lymphoma and multiple myelomaly were summarized.Results: The prothrombin time (PT),activated partial thromboplastin time (APTT),D-dimer (D-D) and fibrin degradation product (FDP) in patients with AL,lymphoma and multiple myelomaly were significantly different from those of the normal control (P<0.05-P<0.01);the PT,APTT,D-D and FDP between M3 sabutype AL and non-M3 abutype AL in patients with acute lymphoblastic leukemia differed significantly (P<0.05) compared with those in other groups;the fibrinogen (FIB) presented no significant difference among the groups (P>0.05).The blood coagulation index in patients with lymphoma was not statistically different (P>0.05).Conclusions: The coagulation and fibrinolysis are abnormal in patients with hematological malignancy.Detection of FIB,D-D and FDP may help to judge whether the patients are in a state of hypercoagulability,which will provide basis for early intervention;detection of PT and APTT may provide evidence for the occurrence of disseminated intravascular coagulation and the application of clinical medication.
Objective: To explore the significance of the changes of blood coagulation index in patients with malignant blood system diseases.Methods: The difference of the blood coagulation index in 135 patients with malignant neoplastic hematologic disorder was analyzed retrospectively,and the changes of the blood coagulation index in patients with acute leukemia (AL),chronic leukemia (CL),lymphoma and multiple myelomaly were summarized.Results: The prothrombin time (PT),activated partial thromboplastin time (APTT),D-dimer (D-D) and fibrin degradation product (FDP) in patients with AL,lymphoma and multiple myelomaly were significantly different from those of the normal control (P<0.05-P<0.01);the PT,APTT,D-D and FDP between M3 sabutype AL and non-M3 abutype AL in patients with acute lymphoblastic leukemia differed significantly (P<0.05) compared with those in other groups;the fibrinogen (FIB) presented no significant difference among the groups (P>0.05).The blood coagulation index in patients with lymphoma was not statistically different (P>0.05).Conclusions: The coagulation and fibrinolysis are abnormal in patients with hematological malignancy.Detection of FIB,D-D and FDP may help to judge whether the patients are in a state of hypercoagulability,which will provide basis for early intervention;detection of PT and APTT may provide evidence for the occurrence of disseminated intravascular coagulation and the application of clinical medication.
2011, 36(4): 413-416.
Abstract:
Objective: To analyze the factors affecting the quality of life (QOL) of adults with epilepsy,and to explore the nursing strategies.Methods: Eighty-four patients with epilepsy were evaluated by general condition questionnaire,quality of life (QOL) in epilepsy inventory-31,social support scale,coping style questionnaire and general self-efficacy scale,and sixty healthy persons acted as control.Results: The QOL of the epilepsy group was significantly poor as compared with that of the normal control (P<0.05).The scores in general self-efficacy,coping style and social support were significantly different between the epilepsy group and the normal control group (P<0.05).The QOL score had no correlation with the gender,marriage,academic level,occupation or the type of seizure;the QOL score was negatively associated with the seizure frequency,duration of epilepsy,degree of delusion,self-reproach and retreat (P<0.05),while it was positively associated with the economic status,social support,self-efficacy,ability of solving problems and seeking help (P<0.05).Multiple regression analysis showed that the factors affecting the quality of life of the epilepsy patients were self-reproach,delusion,self-efficacy,economic status and seizure frequency in the recent 3 months.Conclusions: The life quality of the adults with epilepsy is affected by biological,psychological and social factors,and multiple interferences may help to enhance their QOL.
Objective: To analyze the factors affecting the quality of life (QOL) of adults with epilepsy,and to explore the nursing strategies.Methods: Eighty-four patients with epilepsy were evaluated by general condition questionnaire,quality of life (QOL) in epilepsy inventory-31,social support scale,coping style questionnaire and general self-efficacy scale,and sixty healthy persons acted as control.Results: The QOL of the epilepsy group was significantly poor as compared with that of the normal control (P<0.05).The scores in general self-efficacy,coping style and social support were significantly different between the epilepsy group and the normal control group (P<0.05).The QOL score had no correlation with the gender,marriage,academic level,occupation or the type of seizure;the QOL score was negatively associated with the seizure frequency,duration of epilepsy,degree of delusion,self-reproach and retreat (P<0.05),while it was positively associated with the economic status,social support,self-efficacy,ability of solving problems and seeking help (P<0.05).Multiple regression analysis showed that the factors affecting the quality of life of the epilepsy patients were self-reproach,delusion,self-efficacy,economic status and seizure frequency in the recent 3 months.Conclusions: The life quality of the adults with epilepsy is affected by biological,psychological and social factors,and multiple interferences may help to enhance their QOL.
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