Author Login
Experts Review
Academic Editor
Editor-in-chief
2020 Vol. 45, No. 11
Display Method:
2020, 45(11): 1453-1457.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.001
Abstract:
ObjectiveTo observe the effects of irbesartan on myocardial injury in diabetic rats, and to explore the effect of irbsartan on MAPKs signaling pathway and related factors expression. MethodsFifty male SD rats were randomly divided into the four weeks of diabetes (DM4W) group, eight weeks of diabetes(DM8W) group, eight weeks of diabetes + irbesartan(DM8W+Ir) group, control(Con) group and high sugar and cholesterol diet(HC) group(10 rats in each group).After the model of type 2 diabetic rats were successfully established, the DM8W+Ir group was administered using irbesartan solution by gavage.At the fourth week of feeding, the DM4W group was sacrificed, and heart tissue specimens were collected.After 8 weeks of feeding, the remaining rats were sacrificed.The fasting blood glucose(FBG), body weight(BW), heart to body ratio(H/B) and left ventricular mass index(LVWI) were compared among five groups.The Masson staining was used to observe the changes of myocardial fibrosis in isolated rat myocardium.The levels of IL-1β, IL-6, IL-1 and IL-1 were detected using ELISA.Western blotting was used to detect the expression levels of mitogen-activated protein kinase-1(MKP-1), P38 mitogen-activated protein kinase(P38MAPK) and extracellular signal-related kinases(P-ERK1/2) in myocardium. ResultsThere was no statistical significance in the levels FBG, BW, H/B, LVWI, IL-1β, IL-6 and IL-1, MKP-1, and protein levels of P38MAPK, P-ERK1/2 between HC group and Con group(P>0.05).Compared with the Con group and HC group, the fibrotic changes of Masson staining myocardial cells were observed, the body weight lightened, the expression levels of inflammatory cytokines IL-1, IL-6 and IL-1 in myocardial cells increased, the protein expression levels of MKP-1 in myocardial tissues decreased, and the protein expression levels of P38MAPK and P-ERK1/2 increased in diabetic rats(P < 0.05 to P < 0.01).Compared with the DM4W and DM8W groups, the expression levels of IL-1 β, IL-6 and IL-1 decreased, the expression level of MKP-1 protein increased, and the expression levels of P38MAPK and P-ERK1/2 decreased in DM8W+Ir group(P < 0.05 to P < 0.01). ConclusionsIrbesartan can improve the diabetic myocardial injury by regulating the MAPKs signaling pathway.
2020, 45(11): 1458-1461, 1466.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.002
Abstract:
ObjectiveTo study the effects of nicotine on the circadian clock gene expression rhythm in primary rat aortic vascular smooth muscle cells(VSMCs). MethodsThe primary VSMCs were extracted using adherent method.The expression level of marker α-SMA of VSMCs was detected using immunofluorescence method, the viability was detected using MTT assay, and the expression rhythm of Bmal1, CLOCK, Per1 and Cry1 genes in VSMCs cells was detected using RT-PCR.The data were fitted using the cosine method to calculate circadian parameters. ResultsThe 100 nmol/L of nicotine could induce the best proliferation of VSMCs for 48 hours.Compared with the control group, the median value of Bmal1 and CLOCK genes expression were down-regulated(P < 0.05 and P < 0.01), the median value of Per1 and Cry1 genes expression were up-regulated, the amplitude of Per1 and Cry1 genes expression were down-regulated, the amplitude of Per1 and Cry1 genes expression were up-regulated, and the differences of which were statistically significant(P < 0.05 to P < 0.01). ConclusionsNicotine can change the circadian clock gene expression in VSMCs within 48 hours, and induce specific proliferation of VSMCs, and produce phenotypic differentiation.
2020, 45(11): 1462-1466.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.003
Abstract:
ObjectiveTo explore the protective effects of rutin on myocardial injury induced by perfluorooctanoic acid(PFOA) exposure in mice. MethodsPFOA was used to establish a model of myocardial injury in mice, and the effects of rutin on the body weight, heart weight, myocardial TG, TC content, serum LDH activity, and oxidative stress indicators(myocardial MDA content, GSH-PX and T-SOD activity) and myocardial morphology were investigated in mice. ResultsThere was no statistical significance in the weight of 1-2 d mice among all groups(P>0.05).The differences of in the weight of 3- 14 d mice on day 8 to day 14 among all groups were statistically significant(P < 0.05), and the weight of mice in PFOA group was lower than that in PFOA+rutin group, the heart weight of mice in PFOA group and PFOA+rutin group was lower than that in control group after 14 days of intervention, while the heart weight of mice in PFOA+rutin group was higher than that in PFOA group(P < 0.05).After 14 days of intervention, the myocardial TC content and serum LDH activity in PFOA group were higher than those in control group(P < 0.05), the myocardial TG content and serum LDH activity in PFOA+rutin group were lower than those in PFOA group(P < 0.05), and the difference of the myocardial TC content between PFOA group and PFOA+rutin group was not statistically significant(P>0.05).After 14 days of inverention, the myocardial MDA content and in PFOA group was higher than those in control group(P < 0.05), but there was no statistical significance in myocardial GSH-PX activity between PFOA group and the control group(P>0.05), the myocardial MDA content in PFOA+rutin group was lower than that in PFOA group, while the differences of the myocardial MDA content and GSH-PX activity between PFOA+rutin group and PFOA group were not statistically significant(P>0.05). ConclusionsRutin intervention can ameliorate the myocardial injury induced by PFOA exposure in mice.
2020, 45(11): 1467-1471.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.004
Abstract:
ObjectiveTo explore the effects of lincRNA TUG1 regulating miRNA-145 on the proliferation, migration and invasion of colon cancer cells. MethodsHuman colon cancer cell line HCT116 was divided into 6 groups, and cultured for 48 h.The expression levels of TUG1 and miRNA-145 in each group were detected using qRT-PCR.The proliferation of cells was detected using MTT assay, and the ability of cell migration and invasion were detected using scratch test and Transwell invasion test.The targeting relationship between TUG1 and miRNA-145 was verified by dual-luciferase reporter gene assay. ResultsCompared with human normal colonic mucosal epithelial cell line NCM460, the relative expression level of TUG1 in colon cancer cell line HCT116 significantly increased, while the relative expression level of miRNA-145 significantly decreased(P < 0.01).There were binding sites for miRNA-145 and TUG1 3'-UTR.Compared with the si-con group, the TUG1 expression level and proliferation activity of HCT116 cells in the TUG1 siRNA group significantly decreased, the relative width of cell scratch significantly increased, and the number of invaded cells significantly decreased(P < 0.05).Compared with the miRNA NC group, the miRNA-145 expression level in the miRNA-145 mimic group significantly increased, the proliferation activity of HCT116 cells significantly decreased, the relative width of cell scratch significantly increased, and the number of invaded cells significantly decreased(P < 0.05).Compared with the SI-CON group, the expression level of miRNA-145 in TUG1 siRNA group significantly increased(P < 0.05).Compared with the si-TUG1+miRNA NC group, the expression level of miRNA-145 in the TUG1 siRNA+ mirNA-145 inhibitor group significantly reduced(P < 0.05), the proliferation activity of HCT116 cells significantly enhanced, the relative width of cell scratche significantly reduced, and the number of invaded cell significantly increased(P < 0.05). ConclusionsThe expression level of TUG1 is up-regulated and the expression level of miRNA-145 is down-regulated in colon cancer HCT116 cells.Interfering with the expression of TUG1 can inhibit the proliferation, migration and invasion of colon cancer HCT116 cells by targeting up-regulation of miRNA-145 expression.
2020, 45(11): 1471-1473, 1477.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.005
Abstract:
ObjectiveTo investigate the effect of serum level of heparin-binding protein (HBP) on the prognosis of patients with sepsis. MethodsThe serum levels of HBP and procalcitonin (PCT) were measured, and the acute physiology and chronic health (APACHE Ⅱ) and sequential organ failure (SOFA) scores were evaluated in 108 patients with sepsis.According to the prognosis, the patients were divided into survival group (81 cases) and death group (27 cases).Serum HBP and PCT levels, APACHE Ⅱ and SOFA scores were compared between the two groups.The correlations of HBP and PCT levels, APACHE Ⅱ and SOFA scores were analyzed.Logistic regression analysis was used to analyze the risk factors of prognosis in patients with sepsis. ResultsThe HBP and PCT levels, APACHE Ⅱ and SOFA scores in death group were significantly higher than those in survival group of patients with sepsis (P < 0.01).The HBP level in patients with APACHE Ⅱ score≥15 points was significantly higher than that of patients with APACHE Ⅱ score < 15 points (t=6.13, P < 0.01), and the HBP level in patients with SOFA score ≥5 points was significantly higher than that of patients with SOFA score < 5 points (t=5.64, P < 0.01).The HBP and PCT levels, APACHE Ⅱ and SOFA scores were significantly positively correlated (r=0.793, 0.735, 0.708, P < 0.01).Logistic regression analysis showed that HBP and PCT were independent risk factors of sepsis (P < 0.05). ConclusionsThe level of HBP in patients with sepsis is significantly increased, which is an independent risk factor of death and can predict the prognosis of patients with sepsis to some extent.
2020, 45(11): 1474-1477.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.006
Abstract:
ObjectiveTo compare the efficacy of different approaches in the treatment of neurogenic tumors of parapharyngeal space. MethodsTwenty-one neurogenic tumors of parapharyngeal space patients diagnosed by department of imaging and department of otolaryngology head and neck, and treated with operation were investigated, and the nature of tumors were determined according to its imaging characteristics.The intraoperative bleeding, postoperative pain and complications were compared between transoral approach and transoral approach. ResultsThe differences of the intraoperative bleeding and postoperative pain between transoral approach and transcervical approach were statistically significant(P < 0.05), and there was no statistical significance in the complications between the two approaches(P>0.05). ConclusionsImaging has clinical guiding value in the diagnosis, differential diagnosis and surgical approach selection of neurogenic tumors in parapharyngeal space.transoral approach has advantages over transcervical approach in reducing intraoperative bleeding and postoperative pain.
2020, 45(11): 1478-1480, 1485.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.007
Abstract:
ObjectiveTo observe the clinical efficacy of autologous platelet-rich gel(APG) in the treatment of refractory diabetic foot ulcers(DFU). MethodsForty-five patients with refractory DFU were randomly divided into the observation group(25 cases) and control group(20 cases).The observation group were treated with, and the control group were treated with traditional surgical dressing change.The ulcer healing rate, ulcer surface reduction rate and healing time between two groups were compared after treatment, and the pathological sections of ulcer tissue in observation group before and after APG were made. ResultsThe healing rate, reduction rate of ulcer surface and healing time in observation group were 80.00%, (0.48±0.56)cm2/w and (26.7±3.0)d, respectively.The healing rate, reduction rate of ulcer surface and healing time in control group were 24.00%, (0.29±0.09)cm2/w and (50.3±3.7)d, respectively.The healing rate and time in observation group were better than those in control group(P < 0.01), and the difference of reduction rate of ulcer surface between two groups was not statistically significant(P>0.05).After APG was applied in the observation group, the results of pathological section of ulcer surface showed that a small amount of neovascularization and granulation tissue generated. ConclusionsCompared with traditional surgical dressing change, APG has a good effects on the healing of refractory DFU, which can significantly improve the healing rate, and shorten the healing time of ulcer surface.
2020, 45(11): 1481-1485.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.008
Abstract:
ObjectiveTo investigate the clinical significance of the level change of serum vascular endothelial growth factor(VEGF) in patients with acute cerebral infarction(ACI). MethodsThe clinical data of 46 patients with the first cerebral infarction and hospitalized within 24 hours from March to November 2019 were collected.The double antibody sandwich enzyme-linked immunosorbent assay(ELISA) was used to continuously measure the fasting serum VEGF level after 1, 3, 7, and 14 days of admission.The patients at admission were divided into the mild, moderate and severe groups according to the neurological impairment score using the National Institutes of Health Stroke Scale(NIHSS).The patients were reevaluated after 14 days of onset.If the NIHSS score decreased by ≥4 points compared with that at admission or was less than 4 points at admission, and the NIHSS score did not increase after re-evaluation, the patients were defined as the group with good prognosis, and conversely as the group with poor prognosis.In addition, 15 normal healthy people with matched age and sex at the same stage measured by brain CT or MRI imaging were set as the control group. ResultsCompared with the control group, the serum VEGF level in ACI group significantly increased on day 1, 3, 7 and 14 of onset(P < 0.01), peaked after 7 days of ACI, and decreased after 14 days of ACI(P < 0.01).The serum VEGF level in ACI patients increased with the increasing of severity of disease at different time points.But except for 7th and 14th days after the onset, there was no statistical significance in the serum VEGF level among the mild, moderate and severe groups(P>0.05).The serum VEGF level of ACI patients in poor prognosis group showed a higher trend compared with the good prognosis group at all time points.And on the 3rd and 7th day after ACI, there were statistical differences between the two groups.The results of further subgroup analysis showed that under the same severity of stroke, the serum VEGF level in poor prognosis group had a higher trend compared with the good prognosis group at all time points.But except for 1 day 3 d day after the onset in mild stroke group(P < 0.01), the difference of the VEGF level between poor and good prognosis groups was not statistically significant(P>0.05).The serum VEGF levels in ACI patients on day 3, day 7 and day 14 of onset were positively correlated with the NIHSS score on admission(P < 0.05), and the correlation coefficients were 0.305, 0.346 and 0.355, respectively.There was no correlation between the NIHSS score and serum VEGF level on day 1 of the onset in ACI patients(P>0.05). ConclusionsThe serum VEGF level increases after the occurrence of ACI, and it fluctuates with the progression of ACI.The serum VEGF level is related to the severity of ACI.There is a correlation trend between serum VEGF level and short-term functional prognosis.
2020, 45(11): 1486-1490.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.009
Abstract:
ObjectiveTo investigate the predictive value of dynamic monitoring the neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the chemotherapeutic effects and lifetime of lung adenocarcinoma patients. MethodsThe clinical data of 193 advanced lung adenocarcinoma patients treated with first-line chemotherapy were retrospectively analyzed.The relevant data of patients before chemotherapy, after 2 and 4 cycles of chemotherapy were collected.The curative effects of patients were evaluated, and the NLR and PLR were calculated.The relationship between the dynamic changes of NLR and PLR, and various clinical features, first-line chemotherapy efficacy and overall survival(OS) were analyzed. ResultsThe levels of NLR and PLR in PD group before and after chemotherapy were higher than those in CR group, PR group and SD group(P < 0.01).In terms of the efficacy of chemotherapy, except for NLR4(P>0.05), the NLR0, NLR0, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 2-cycle chemotherapy(P < 0.05 to P < 0.01).The NLR0, NLR2, NLR4, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 4-cycle chemotherapy(P < 0.01).The results of Kaplan-Meier survival analysis showed that the OS was significantly correlated with the NLR0, NLR4, PLR0, PLR2, PLR4, efficacy of 2-cycle chemotherapy and efficacy of 4-cycle chemotherapy(P < 0.01).The results of multivariate analysis showed that the NLR0 and PLR4 were the independent risk factors of survival(P < 0.05 and P < 0.01). ConclusionsThe NLR and PLR are closely related to the efficacy and survival of first-line chemotherapy for advanced lung adenocarcinoma.The NLR before treatment and PLR after 4 cycle chemotherapy are the independent prognostic factors of advanced lung adenocarcinoma patients treated with first-line chemotherapy.
2020, 45(11): 1491-1493, 1497.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.010
Abstract:
ObjectiveTo explore the application value of the detection of serum myeloperoxidase(MPO) and fractional exhaled nitric oxide(FeNO) in severe asthma phenotyping. MethodsForty patients with stable bronchial asthma included 20 cases with severe asthma and 20 cases with non-severe asthma.Twenty cases with severe asthma, 20 cases with non-severe asthma and 20 healthy people were divided into the severe asthma group, non-severe asthma group and control group, respectively.The serum level of MPO was detected using enzyme-linked immunosorbent assay, and the FeNO level was detected using FeNO detector.The neutrophilic granulocyte count, eosinophile granulocyte count and IgE level in the peripheral blood were also detected.The levels of serum MPO, FeNO, neutrophilic granulocyte, eosinophile granulocyte and IgE among three groups were compared. ResultsThe differences of the serum MPO level among three groups were statistically significant(P < 0.01), and the serum MPO level in severe asthma group was significantly higher than that in control group and non-severe asthma group(P < 0.01).The difference of the neutrophil level in peripheral blood among three groups was not statistically significant(P>0.05).The differences of the levels of FeNO and IgE among three groups were statistically significant(P < 0.01), the FeNO level in severe asthma group was significantly higher than that in control group and non-severe asthma group(P < 0.01), and the levels of IgE in non-severe asthma group and severe asthma group were higher than that in control group(P < 0.05 and P < 0.01).There was no statistical significance in the eosinophil level among three groups(P>0.05). ConclusionsThe serum levels of MPO and FeNO in severe asthma patients increase.The detection of serum MPO and FeNO level is helpful to identify phenotypes in patients with severe bronchial asthma, which has great significance in the individualized treatment of disease.
2020, 45(11): 1494-1497.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.011
Abstract:
ObjectiveTo investigate the effect of estradiol (E2) level on the human chorionic gonadotropin(hCG)day of antagonist protocol on the pregnancy outcome of fresh embryo transfer cycle. MethodsThe clinical data of 216 cycles of in vitro fertilization and embryo transfer/intra cytoplasmic sperm injection (IVF/ICSI) antagonist protocol were retrospectively analyzed.According to the E2 level on hCG day, the patients were divided into group A (< 1 600 pg/mL), group B (1 600-3 200 pg/mL), group C (>3 200-4 800 pg/mL), and group D (>4 800 pg/mL).The number of obtained oocytes, E2 level of single follicle, number of obtained embryos, fertilization rate, cleavage rate, high-quality embryo rate, embryo implantation rate, clinical pregnancy rate and early abortion rate were compared between the two groups. ResultsThe number of obtained oocytes and obtained embryos in group B, group C and group D was higher than that in group A, which in group C and group D was higher than that in group B, and which in group D was higher than that in group C(P < 0.05).The E2 level of single follicle in group C and group D was higher than that in group A, which in group D was higher than that in group B (P < 0.05).The embryo implantation rate in group D was lower than that in group B and group C (P < 0.05).There was no statistical difference in fertilization rate, cleavage rate, high-quality embryo rate, clinical pregnancy rate and early abortion rate among the four groups (P>0.05). ConclusionsIn the antagonist protocol, the number of obtained oocytes and embryos in patients with high E2 level increases, and the rate of high-quality embryos is not affected, but the implantation rate of fresh embryo transfer decreases.
2020, 45(11): 1498-1500, 1504.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.012
Abstract:
ObjectiveTo study the effects of budesonide combined with high-flow oxygen therapy on nitric oxide(NO) and lactate in children with acute respiratory distress syndrome(ARDS). MethodsNinety children with ARDS were randomly divided into the oxygen therapy group and combined group.The oxygen therapy group was treated with transnasal high-flow oxygen therapy, and the combined group was additionally treated with budesonide on the basis of the oxygen therapy group.The levels of PaO2, PaCO2, oxygenation index, NO and lactate, and pulmonary function before and after treatment were compared between two groups. ResultsAfter treatment, the level of PaCO2, and levels of PO2 and oxygenation index in two groups significantly decreased and increased compared with before treatment, respectively(P < 0.05 to P < 0.01), and the levels of PaCO2, PO2 and oxygenation index in combined group were significantly lower and higher than those in oxygen therapy group, respectively(P < 0.01).After treatment, the levels of NO and lactate in two groups decreased compared with before treatment(P < 0.05), and which in combined group were significantly lower than those in oxygen therapy group(P < 0.01).After treatment, the levels of TV, FEV, FEV1 and PEF in combined group were significantly higher than those in oxygen therapy group(P < 0.01).The effective rate in the combined group and oxygen therapy group was 93.33% and 77.78%, respectively, and the difference of which was statistically significant(P < 0.01). ConclusionsBudesonide combined with high-flow oxygen therapy in the treatment of children with ARDS has a good effect, which can improve the levels of NO and lactate, and respiratory function.
2020, 45(11): 1501-1504.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.013
Abstract:
ObjectiveTo observe the effects of acetylcysteine adjuvant therapy on pulmonary artery pressure(PASP), right ventricular ejection fractions(RVEF) and serum levels of C-reactive protein(CRP) and superoxide dismutase(SOD) in elderly patients with chronic obstructive pulmonary disease(COPD) at stable stage, and investigate its clinical application value. MethodsSixty-six elderly patients with stable COPD were divided randomly into the control group and observation group(33 cases in each group).The control group was treated with conventional therapy, and observation group was treated with conventional therapy combined with oral acetylcysteine for 2 months.The levels of PASP and RVEF were detected using echocardiography, and the serum levels of CRP and SOD were measured in two groups before and after 1 and 2 months of treatment. ResultsAfetr treatment, the levels of PASP and CRP in two groups decreased compared with before treatment, and the differences of the decreasing degree of levels of PASP and CRP between two groups after 2 months of treatment were statistically significant(P < 0.05 and P < 0.01).Afetr treatment, the levels of SOD in two groups increased compared with before treatment, and the difference of the increasing degree of level of SOD between two groups was statistically significant(P < 0.05 and P < 0.01).The differences of the increasing degree of RVEF between and within two groups were not statistically significant(P>0.05). ConclusionsThe combined use of acetylcysteine in the treatment of elderly patients with COPD at stable stage is beneficial to the control of pulmonary artery pressure by inhibiting inflammatory response and improving antioxidant capacity, which has clinical application value.
2020, 45(11): 1505-1507, 1511.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.014
Abstract:
ObjectiveTo investigate the predictive value of blood lactate level on the prognosis of severe pneumonitis patients with acute respiratory distress syndrome(ARDS) complicated with septic shock at admission, and provide evidence for the clinical prediction of patient's mortality. MethodsA total of 102 severe pneumonia patients with ARDS complicated with septic shock were selected, and the clinical and biochemical data of patients were collected.The patients were divided into the death group and survival group according to the survival condition after 28 days of admission.The correlation between blood lactate level and mortality was observed, and the predictive value of 28-day mortality was analyzed. ResultsThere were 40 deaths(39.2%).The SOFA score and APACHE Ⅱ score in death group were higher than those in survival group(P < 0.05), the hospital stay in death group was longer than that in survival group(P < 0.01), and the blood lactate level in death group was higher than that in survival group(P < 0.01).The differences of the levels of pH, BE, bicarbonate, PCO2 and PO2 between two groups were not statistically different(P>0.05).The results of ROC analysis showed that the area under the curve of lactate predicting 28-day mortality was 0.77, and the specificity and sensitivity were 64.2% and 79.9%, respectively.The results of multivariate analysis showed that the lactate[OR(95% CI):3.458(1.441-10.027)] and SOFA score[OR(95% CI):1.524(1.276-5.034)] were the independent risk factors of 28-day mortality of patients(P < 0.01 and P < 0.05). ConclusionsThe severe pneumonia patients with ARDS complicated with septic shock with increasing arterial blood lactate level have a poor prognosis, and the arterial blood lactate level can be used to predict 28-day mortality.
2020, 45(11): 1508-1511.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.015
Abstract:
ObjectiveTo observe the effects of dacronine hydrochloride glue on the postoperative restlessness and discomfort of indwelling urethral catheter in patients treated with upper ureteral holmium laser lithotripsy. MethodsSixty male patients scheduled by upper ureteral holmium laser lithotripsy were randomly divided into the group C and group A.The group C was treated with indwelling catheter at the end of operation, and the group A was treated with indwelling catheter at the end of transurethral injection of dacronin hydrochloride.The mean arterial blood pressure(MAP), heart rate(HR) and plasma concentrations of epinephrine and norepinephrine were monitored at 30 min before surgery(t0), and at 30 min(t1), 3 h(t2), 6 h(t3), 12 h(t4) and 24 h(t5) after surgery.The recovery time, agitation and VAS scores at 1 h(T1), 3 h(T2), 6 h(T3), 12 h(T4), 24 h(T5) and 48 h(T6) after the operation of general anesthesia were observed in two groups. ResultsCompared at t0, the levels of E, NE, MAP and HR in C group at t1 to t3, and group A at t1 to t2 significantly increased(P < 0.05 to P < 0.01).At t1 to t3, the levels of E, NE, MAP and HR in group A were significantly lower than those in group C(P < 0.01).The RASS score in group A during anesthesia recovery period was significantly better than that in group C(P < 0.01).The VAS score in group A was significantly lower than that in group C at T1 to T6 after surgery(P < 0.01). ConclusionsThe application of dacronine hydrochloric acid gel before indwelling urethral catheter in male patients after surgery can effectively reduce the occurrence of agitation during the recovery period and discomfort of the indwelling urethral catheter.
2020, 45(11): 1512-1514, 1517.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.016
Abstract:
ObjectiveTo investigate the expression levels of 8-isoprostane, SOD, AOA, NF-kB and iNOS in patients with recurrent spontaneous abortion and their effects, and explore the pathogenesis of unexplained recurrent spontaneous abortion. MethodsFrom January 2018 to October 2019, 119 maternal patients were selected, and divided into the case group(60 cases with unexplained recurrent abortion) and control group(59 cases with normal pregnancy delivery).The levels of 8-isoprostane, SOD, AOA and other oxidative stress indicators(NF-κB and iNOS) in the blood and villous decidua tissue were compared between two groups. ResultsThere was no statistical significance in the AOA level in blood between two groups(P>0.05), the levels of 8-isoprostane, NF-κB and iNOS in case group were significantly higher than those in control group(P < 0.01), and the SOD level in case group was significantly lower than that in control group(P < 0.01).The difference of the AOA level in chorion decidua tissue between two groups was not statistically significant(P>0.05), the levels of 8-isoprostane and NF-κ in chorion decidua tissue in case group were higher than those in control group(P < 0.01), and the level of SOD in case group was lower than that in control group(P < 0.01). ConclusionsThere are significant differences in the expression levels of 8-isoprostane, SOD, NF-κB and iNOS in blood and chorion decidua tissue between patients with unexplained recurrent abortion and normal pregnant women, and they can be used as an important factor to predict the occurrence of unexplained recurrent spontaneous abortion.
2020, 45(11): 1515-1517.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.017
Abstract:
ObjectiveTo compare the clinical value of color Doppler ultrasound detection of fetal umbilical artery (UA) and middle cerebral artery (MCA) hemodynamics in predicting fetal distress in late pregnancy. MethodsPregnant women in late pregnancy were selected and randomly divided into fetal distress group(n=80) and non-fetal distress group(n=200).UA indexes including systolic and diastolic velocity ratio (S/D), resistance index(RI) and blood flow pulsation index(PI) were detected in 40 patients, and MCA indexes including RI and PI were detected in other 40 patients from fetal distress group.UA indexes including S/D, RI and PI were detected in 100 patients, and MCA indexes including RI and PI were detected in other 100 patients from non-fetal distress group. ResultsUA indexes including S/D, RI and PI in fetal distress group were significantly higher than those in non-fetal distress group(P < 0.01), and MCA indexes including RI and PI in fetal distress group were significantly lower than those in non-fetal distress group (P < 0.01).The detection rates of UA and MCA indexes for fetal distress were 85.0% (34/40) and 67.5% (27/40), respectively, and the difference of which was statistically significant(χ2=6.05, P < 0.05).The misdiagnosis rates of UA and MCA indexes for fetal distress were 9.0% (9/100) and 2.0% (2/100), respectively, and the difference of which was statistically significant (χ2=4.71, P < 0.05). ConclusionsBoth UA and MCA indexes have important clinical values in the prediction of fetal distress.The detection rate of UA index for fetal distress is higher than that of MCA index, but the misdiagnosis rate of UA index is also higher than that of MCA index.
2020, 45(11): 1518-1520, 1524.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.018
Abstract:
ObjectiveTo investigate the incidence rate and risk factors of deep venous thrombosis(DVT) in the healthy side lower extremity in hemiplegia patients after ischemic stroke. MethodsA total of 147 ischemic stroke patients with hemiplegia were retrospectively analyzed.After admission, the blood routine examination, blood coagulation image, D-dimer and color ultrasound examination in all cases were implemented According to the thrombosis of the healthy side lower extremity, the patients were divided into the healthy side complicated with DVT group(18 cases) and healthy side complicated without DVT group(129 cases).The indexes between two groups were compared. ResultsThere was no statistical significance in the age, coagulation function, platelet count, incidence rate of pulmonary infection, complicated with hypertension, diabetes and atrial fibrillation rate between two groups(P>0.05).The D-dimer, incidence rate of consciousness disorder and ventilator utilization rate in healthy side complicated with DVT group were higher than those in healthy side complicated without DVT group(P < 0.05 to P < 0.01). ConclusionsDisturbance of consciousness and use of ventilator are the risk factors of DVT in the healthy side of patients with hemiplegia after ischemic stroke, and lung infection may be a potential risk factor.For patients with these risk factors, the screening of healthy side lower limb thrombosis should be paid more attention.
2020, 45(11): 1521-1524.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.019
Abstract:
ObjectiveTo investigate the effects of ziprasidone combined with low frequency repetitive transcranial magnetic stimulation on the levels of BNDF, IL-6 and Hcy, and cognitive dysfunction in elderly patients with severe schizophrenia. MethodsOne hundred elderly patients with severe schizophrenia were randomly divided into the observation group and control group(50 cases in each group).The control group was treated with ziprasidone, and the observation group was treated with ziprasidone combined with low frequency repetitive transcranial magnetic stimulation for 2 months.The clinical efficacy, positive and negative symptom scale(PANSS) scores before and after treatment, repeatable battery for the assessment of neuropsychological status(RBANS) scores, levels of Hcy, BDNF and IL-6, and adverse reactions were compared between two groups. ResultsCompared with before treatment, the PANSS scores decreased, the RBANS scores increased in two groups after treatment(P < 0.01).After treatment, the scores of PANSS in observation group was lower than that in control group(P < 0.01), and the scores of RBANS in observation group was higher than that in control group(P < 0.01).Compared with before treatment, the serum level of BDNF increased, the levels of IL-6 and Hcy decreased in two groups after treatment(P < 0.01).After treatment, the serum level of BDNF in observation group was higher than that in control group, and the levels of IL-6 and Hcy in observation group was lower than that in control group(P < 0.01).The effective rate in observation group(96.00%) was higher than that in control group(84.00%) (P < 0.05).There was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05). ConclusionsZiprasidone combined with low frequency repetitive transcranial magnetic stimulation is effective in the treatment of elderly patients with severe schizophrenia.It can improve cognitive impairment, reduce the levels of IL-6 and Hcy, and improve the level of BDNF.It is safe and worthy of promotion.
2020, 45(11): 1525-1528.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.020
Abstract:
ObjectiveTo compare the efficacy and safety between extracorporeal shock wave lithotripsy(ESWL) and ureteroscopy(URS) in the treatment of upper ureteral calculi below the transverse process of L4. MethodsA total of 158 patients with upper ureteral calculi(length diameter 1.0- < 2.0 cm) below the transverse process of L4 were randomly divided into the ESWL group(80 cases) and URS group(78 cases), Two groups were subdivided into the < 1.3 cm group and ≥1.3 cm group according to the length diameter of calculi.The one-time lithotripsy success rate, final lithotripsy success rate, costs stone calculi and complications were compared between two groups. ResultsThe one-time lithotripsy success rate and medical expenses in ESWL group were lower than those in URS group, and the repeated treatment rate in ESWL group was higher than that in URS group(P < 0.01).There was no statistical significance in the final lithotripsy success rate and incidence rate of complications between two groups(P>0.05).In ESWL group, the one-time lithotripsy success rate and final lithotripsy success rate in patients with calculi diameter ≥1.3 cm were lower than those in patients with calculi diameter < 1.3 cm(P < 0.01).In URS group, the difference of the lithotripsy success rate between two subgroups was not statistically significant(P>0.05).For the calculi with diameter ≥1.3 cm, the one-time lithotripsy success rate and final lithotripsy success rate of URS were higher than those of ESEWL(P < 0.01 and P < 0.05).For the calculi with diameter < 1.3 cm, the difference of the curative effect between ESWL and URS was not statistically significant(P>0.05).There was no statistical significance in the incidence rate of complications within and between subgroups(P>0.05). ConclusionsFor the management of upper ureteral calculi below the transverse process of L4, URS can be preferred for patients with calculi diameter 1.3- < 2.0 cm, and ESWL can be suited for patients with calculi diameter 1.0 < 1.3 cm.
2020, 45(11): 1531-1537.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.022
Abstract:
ObjectiveTo learn the acceptance of the second-born children by urban school-age children and explore the relationship between their aggressive behavior and the acceptance of the second-born children. MethodsA stratified cluster sampling method was adopted to select three schools in Bengbu city.A total of 926 the only children and the first-born children of primary school from the second to sixth grades were selected as subjects for questionnaire survey.The content of the questionnaire included the basic situation of children, the 12-item aggression questionnaire, family status and acceptance status assessment questionnaire. ResultsThere were 531 (57.34%) the only children and 395 (42.66%) the first-born children among the 926 primary school students.The acceptance rate of the second-born children by the first-born children was significantly higher than that by the only children (P < 0.01).The score of the first-born children in the physical aggression dimension was significantly higher than that of the only children (P < 0.01).Multivariate logistic regression analysis showed that the high tendency of physical aggression and language aggression were the limiting factors for the acceptance of the second-born children by the only children, age growth was a contributing factor for the acceptance of the second-born children by the first-born children, and the high tendency of physical aggression, language aggression and hostility were the restricting factors for the acceptance of the second-born children by the first-born children. ConclusionsIn order to promote children's social development, reduce children's aggression and improve the acceptance of compatriots, it is recommended that parents should do a good job of psychological counseling for the only children and the first-born children and adopt democratic and equal education mode, and schools can try mixed-age education models and carry out family school for parents to promote children's acceptance for the second-born children.
2020, 45(11): 1537-1543.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.023
Abstract:
ObjectiveTo investigate the status and influencing factors of knowledge-attitude-practice of breast cancer among female college students in Wuhu city, to provide suggestions and measures for breast cancer prevention and health education. MethodsA total of female college students from four universities in Wuhu city were randomly selected to fill in the self-designed questionnaires. ResultsThe total awareness rate of breast cancer among female college students in Wuhu city was 70.79%, the total attitude holding rate of breast cancer was 71.15%, and the total formation rate of breast cancer prevention behavior was 62.31%.The score of knowledge-attitude-practice of medical students in Wuhu city was higher than that of other majors, the fifth year students had the highest score, the score got higher with the increasing of their mothers' education degree, and the students who had received breast cancer health education scored higher than those who had not received education (P < 0.05).The knowledge-attitude-practice of breast cancer were positively correlated with each other (P < 0.01).Profession, education degree of mother, and breast cancer health education were the influencing factors of breast cancer knowledge; grade, education degree of mother, and breast cancer health education were the influencing factors of attitude; major, grade, education degree of mother, breast cancer health education, and family history of breast cancer were the influencing factors of practice; and major, grade, education degree of mother, and breast cancer health education were the influencing factors of knowledge-attitude-practice. ConclusionsThe knowledge and attitude of breast cancer among female college students in Wuhu city is generally positive, the practice is slightly poor.The work of breast health education should be further strengthened to improve female college students' knowledge-attitude-practice level of breast cancer.
2020, 45(11): 1544-1549, 1553.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.024
Abstract:
ObjectiveTo investigate the difference of the mental health service demands between rural school minors with different demographic characteristics, and provide the reference in formulating mental health intervention strategies for rural minors. MethodsUsing the stratified random cluster sampling, 3 456 rural school minors from grade 4 to 9 were selected in Sichuan, Anhui and Henan province for April to July 2018.The acquisition and demands of mental health service of rural school minors were investigated using the self-designed questionnaire. ResultsThe 61.1% of the subjects wanted to obtain mental health services, and the variables with statistical significance were grade, score, residential status and family economic status(P < 0.01).The psychological counselors(51.5%) were the main way to obtain services, and the variables with statistical significance were the gender, grade, performance, and residential status(P < 0.01).The subjects hoped to obtain services through face-to-face communication(45.1%) and internet(28.3%), and the variables with statistical significance were gender, grade, residential situation, education mode and family economic status(P < 0.05 to P < 0.01).The demands for mental health services in subjects with different gender, grade, academic performance, living in school, only-child status, marital status of parents, family education and economic status were different(P < 0.05 to P < 0.01). ConclusionsThe demand for mental health services in rural minors is high, which in the rural minors with different demographic characteristics is different, and they need to obtain mental health services through various ways and means.
2020, 45(11): 1550-1553.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.025
Abstract:
ObjectiveTo investigate the current situation of standardized training for general practitioners in a certain area, to understand and analyze their job satisfaction, and to provide basis for better formulation of standardized training programs and related policies for general practitioners. MethodsThree standardized training bases in a certain place were used as the research site, and the self-made General Demography questionnaire and the short Minnesota satisfaction scale (MSQ) were used, and the convenient sampling method was used.Self-filling questionnaire was conducted on the internet platform by voluntary principle and anonymity. ResultsThe satisfaction of general practitioners to the wages was 76.1% of the total "dissatisfied" and "very dissatisfied".The satisfaction of general practitioners to the policy was 77.4% of the "very familiar" and "knowledgeable"; The total proportion of "very satisfied" and "satisfied" was 37.2%."Very willing" and "willing" to go to basic level employment after the end of general practitioners' regulation training, and the total proportion of those who were "very satisfied" and "satisfied" was 39.5%;and family support was 54.6% of "very supportive" and "more support".General practitioners family support was "very supportive", the scores of total job satisfaction, internal satisfaction and external satisfaction were significantly higher than those of other groups (P < 0.01).The scores of overall job satisfaction, internal satisfaction and external satisfaction were significantly higher in general practitioners who were "very satisfied" with the policy (P < 0.01), and were significantly higher than those in other groups (P < 0.01), and were tested by LSD.Very satisfied >dissatisfied >very dissatisfied. Conclusionsthe general practitioners' satisfaction with salary and policy is low, and their willingness to go to the grass-roots level is lower, and the degree of family support is lower.General Practitioners who were very satisfied with the policy, and those with higher family support scored higher satisfaction.
2020, 45(11): 1554-1558.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.026
Abstract:
ObjectiveTo prepare the timolol maleate phospholipid complex for improving the liposolubility of timolol maleate. MethodsThe timolol maleate phospholipid complex was prepared using solvent evaporation method.According to the recombination rate, the ratio of timolol maleate and soybean phosphatide, formation temperature and time were optimized and screened using single-factor experiment.The phospholipid complex prepared by optimal prescription was verified using differential scanning calorimetry, Fourier infrared spectroscopy and ultraviolet spectroscopy, and its property characterization was investigated.The dissolubilities of timolol maleate and its phospholipid complex in distilled water or chloroform were determined and compared. ResultsThe 10 mL tetrahydrofuran acted as the solvent, the molar ratio of timolol maleate to phospholipid was 1:2.5, the water bath temperature was 40 ℃, and the formation time was 3 h, the recombination rate of timolol maleate phospholipid complex was the highest, which arrived at (96.54±2.46)%.The solubility test results showed that the solubility of timolol maleate phospholipid complex in distilled water was significantly lower than that of timolol maleate, and the solubility of timolol maleate phospholipid complex in chloroform was significantly higher than that of timolol maleate(P < 0.01). ConclusionsTimolol maleate is prepared into phospholipid complex, which improves its lipid solubility, and is beneficial to increase the drugs residence time in skin and mucosa, and prolongs the efficacy.
2020, 45(11): 1558-1560.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.027
Abstract:
ObjectiveTo establish a method for the determination of rhodamine B in dissolving microneedle patch. MethodsUltraviolet-visible spectrophotometry was used to determine the content of rhodamine B in dissolving microneedles.A series concentration of rhodamine B solutions were prepared, the absorbance was measured at 554 nm and the least square method was used to draw the standard curve.The specificity, linearity, precision, sample recovery, limit of detection, repeatability and stability of the method were investigated. ResultsRodamine B solution at the concentration of 1.04-10.40 μg/mL showed good linearity with its absorbance (r=0.999 5).The specificity, linearity, precision, sample recovery, limit of detection, repeatability and stability of the method all met the requirement. ConclusionsThe ultraviolet-visible spectrophotometry is simple, accurate and reliable, and can be used to determine the content of rhodamine B in dissolving microneedle patch.
2020, 45(11): 1561-1564, 1568.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.028
Abstract:
ObjectiveTo explore the effects of the positive psychological intervention on the mental health of undergraduate nursing students. MethodsSixty-six nursing students from grade one to grade three in Bengbu Medical College were screened, and randomly divided into the intervention group(n=32) and control group(n=34).The intervention group was treated with positive psychological intervention for 6 weeks, while the control group was treated with routine psychological activities.The nursing students were investigated using the SDS, SAS, satisfaction with life scale and index of well-being at baseline, after 6 weeks, 1 month and 6 months of intervention. ResultsThe differences of the life satisfaction score, happiness index, depression and anxiety scores between two groups at T0 time-point were not statistically significant(P>0.05).At T1, T2 and T3 time-points, the scores of satisfaction with life in intervention group were higher than that in control group(P < 0.05).The scores of the index of well-being, depression and anxiety in intervention group were lower than those in control group(P < 0.05 to P < 0.01).The differences of the scores of satisfaction with life index of well-being and depression in intervention group among all time-points were not statistically significant(P < 0.01), and the scores of satisfaction with life, index of well-being and depression in intervention group at T1, T2 and T3 were higher than those at T0(P < 0.05 to P < 0.01). ConclusionsThe positive psychological intervention can improve the life satisfaction and well-being, relieve depression, anxiety and negative emotions, and improve the mental health of nursing students.
2020, 45(11): 1565-1568.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.029
Abstract:
ObjectiveTo explore the effects of MOTOmed virtual scenario training on children with spastic cerebral palsy. MethodsOne hundred children with spastic cerebral palsy were randomly divided into the observation group and control group(50 cases each group).The control group received routine training, while the observation group received MOTOmed virtual scenario training.The lower extremity muscle tension, lower extremity joint activity and daily activity ability between the two groups were compared before and after intervention. ResultsThere was no statistical significance in the related indicators between two groups before intervention(P>0.05).After 3 months of intervention, the scores of adductor, hamstring and gastrocnemius in observation group were lower than those in control group (P < 0.01), the angles of adductor and carmine fossa in observation group were higher than those in control group(P < 0.01), the difference of the dorsal flexion angle of foot between two groups was statistically significant(P>0.05), and the activity ability in observation group was stronger than that in control group(P < 0.01). ConclusionsThe application of MOTOmed virtual scenario training in children with spastic cerebral palsy can effectively reduce the muscle tension of lower limbs, improve the range of motion of lower limbs joints, and effectively enhance the daily activity of children, which is worthy of promotion.
2020, 45(11): 1569-1572.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.030
Abstract:
ObjectiveTo explore the application effects of traction garments in the prevention of fall in rehabilitation department. MethodsA total of 143 patients treated with rehabilitation were randomly divided into the observation group(72 cases) and control group(71 cases).The control group was nursed with the conventional nursing method, and the observation group was nursed with traction garments based on the control group.The modified falls efficacy scale(MEFS) score, number of falls and activities of daily living(ADL) score after intervention were compared between two groups. ResultsNo case fell in the observation group, 4 cases fell in the control group, and the difference of which was statistically significant(P < 0.05).There was no statistical significance in MEFS and ADL scores between two groups before intervention(P>0.05).After intervention, the MEFS and ADL scores in two groups significantly increased(P < 0.01), and which in observation group were significantly higher than those in control group(P < 0.01). ConclusionsTraction garments can effectively prevent and control the fall of patients during the rehabilitation, improve the patient's security and self-confidence, and have certain effects on the rehabilitation training of patients.
2020, 45(11): 1573-1578.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.031
Abstract:
ObjectiveTo analyze the nutritional status and its influencing factors in patients with chronic heart failure(CHF), and provide the reference for clinical targeted intervention. MethodsA total of 196 patients with CHF were investigated using the general condition questionnaire, Chinese version of multi-dimensional fatigue scale, hospital anxiety and depression scale, social support rating scale, cardiac insufficiency quality of life scale, heart failure patients comprehensive self-care ability assessment scale and MNA-HF micro-nutrition evaluation scale. ResultsThe MNA-HF micronutrient score of patients with CHF was (17.25±4.36) points, the self-care ability, quality of life of cardiac dysfunction and social support scores in patients with CHF were positively correlated with the MNA-HF micro-nutrition score(P < 0.01), and the fatigue was negatively correlated with the total score of MNA-HF micro-nutrition evaluation scale(P < 0.01).The results of stratified regression showed that the family average monthly income, type of medical insurance, course of disease, ability of self-care and quality of life were the main influencing factors of MNA-HF micro-nutrition in patients with CHF(P < 0.05), which could explain the 46.9% variation in nutritional evaluation. ConclusionsThe nutritional status of patients with CHF needs to be further improved, which is related to the monthly income of family, type of medical insurance, course of disease, self-care ability and quality of life.In the future nursing research, the nutritional status of patients with CHF can be improved by paying more attention to the patients with low income and low reimbursement rate, improving their self-care ability and quality of life to reduce the clinical adverse outcomes and improve the prognosis of patients.
2020, 45(11): 1578-1581.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.032
Abstract:
ObjectiveTo investigate the effects of long-distance fast walking exercise on the postoperative interventional therapy in elderly patients with coronary heart disease(CHD) complicated with hypertension. MethodsA total of 104 elderly CHD complicated with hypertension patients treated with percutaneous coronary intervention was divided into the observation group and control group according to the random number table(52 cases in each group).The control group were treated with routine intervention, and the observation group was additionally treated with long-distance fast walking exercise on the basis of control group.The blood pressure, cardiopulmonary function and quality of life in two groups were compared between before and after intervention. ResultsAfter 6 months of intervention, the systolic blood pressure, diastolic blood pressure and mean arterial pressure in two groups were lower than those before intervention(P < 0.01), and which in observation group was significantly lower than that in control group(P < 0.01).The heart rate(HR), CO2 emission(VCO2), peak oxygen uptake(VO2 peak) and metabolic equivalent in observation group after intervention were significantly higher than those before intervention(P < 0.01), the levels of VCO2 and VO2 peak in observation group were significantly higher than those in control group(P < 0.01), and the HR in observation group was significantly lower than that in control group(P < 0.01).The angina stability, limited physical activity, frequency of angina attack, disease cognition and treatment satisfaction in two groups after intervention were significantly higher than those before intervention(P < 0.01), and the all items scores in observation group were significantly higher than those in control group (P < 0.01). ConclusionsLong-distance fast walking exercise can effectively improve the blood pressure level, cardiopulmonary function and quality of life in elderly patients with CHDcomplicated with hypertension.It is worthy of promotion.
2020, 45(11): 1582-1585.
doi: 10.13898/j.cnki.issn.1000-2200.2020.11.033
Abstract:
ObjectiveTo explore the effects of ultra-light clay manual training in the rehabilitation nursing of patients with hemiplegic upper limb after stroke. MethodsSixty stroke patients from the neurology department were randomly divided into the control group(n=30) and observation group(n=30).Two groups were treated with neurology drug combined with conventional rehabilitation nursing.The observation group was additionally treated with ultra-light clay manual training based on the control group.The Barthel index score, Fugl-Meyer upper extremity score and nursing efficacy were compared between two groups. ResultsThe Barthel index score and Fugl-Meyer upper extremity score in the observation group were higher than those in control group after 1 and 2 months of treatment(P < 0.05).The nursing quality score and satisfaction rate in observation group were higher than those in control group(P < 0.01). ConclusionsThe ultra-light clay manual training can improve the motor function of hemiplegic upper limb and hand, and enhance the nursing quality score and satisfaction of the stroke patients.
Email
RSS