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2020 Vol. 45, No. 2
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2020, 45(2): 141-147.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.001
Abstract:
ObjectiveTo analyze the change trend of death cases of corona virus disease 2019(COVID-19) and its characteristics from the time of onset to death, and to provide a theoretical basis for effectively reducing the mortality of this disease. MethodsThe data on number of new cases, death cases per day and 17 death cases in 31 provinces (autonomous regions, municipalities) issued by the National Health Commission, Health Commission of Hubei Province from January 10, 2019 to February 11, 2020 were collected and analyzed. ResultsUp to 24:00 on February 11, 2020, the mortality of COVID-19 in China was 2.49%, including 3.19% in Hubei province and 0.4% in other provinces (autonomous regions, municipalities).The mortality of COVID-19 reached a peak point on January 15 (4.9% in China and in Hubei province), and then continued to decline to the low point on January 19 (2.02% in China and Hubei province).It reached another peak point from January 24 to 26 (2.85%-3.22% in China, 4.94%-5.35% in Hubei province, and in other provinces (autonomous regions, municipalities) reached a peak point of 0.44% on January 25).It began to decline continuously later, the mortality in China and Hubei province reached a low point on February 5 (2.01% and 2.79%, respectively), and in other provinces (autonomous regions, municipalities) reached the lowest point of 0.14% on February 4, then began to rise continuously from February 5.The time of onset to death in cases of male, ≥70 years old, no cough symptoms, shortness of breath or wheeze or dyspnea, no fatigue or general soreness was shorter. ConclusionsThe mortality of COVID-19 may be on the rise.It is necessary to strengthen publicity of prevention and control knowledge, improve the awareness of early medical treatment, and shorten the time of consultation.
2020, 45(2): 147-149.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.002
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ObjectiveTo analyze and trace the origin of cluster outbreak of corona virus disease 2019 in a city, and to provide a scientific basis for effective prevention and control. MethodsAn epidemiological survey was conducted for all the patients and their close contacts by epidemiological investigation of case, and the information was analyzed by combination with the big data of the Public Security Bureau. ResultsThis cluster epidemic originated from a gymnasium caused 13 cases of infection directly, 38 cases of infection indirectly, and 2 cluster outbreaks.The incidence of corona virus disease 2019 in gymnasium members was 2.64%. ConclusionsStrengthening the traceability of case and isolating the source of infection can effectively control the spread of disease.
2020, 45(2): 150-153, 155.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.003
Abstract:
ObjectiveTo investigate the clinical and imaging features of the corona virus disease 2019(COVID-19). MethodsThe clinical data and pulmonary high-resolution CT (HRCT) findings of 32 patients with clinically diagnosed COVID-19 were retrospectively analyzed.According to the range and type of lesions, the patients were divided into early stage, progressive stage, termination stage and severe stage, and their HRCT findings were analyzed. ResultsThere were more male patients than female patients (1.5:1), and most patients had direct or indirect contact history with Wuhan personnel.Fever (84.3%) and cough (59.4%) were the main clinical manifestations, and lower leukocyte count (62.5%), lower lymphocyte count (65.6%) and higher C-reactive protein (71.9%) were common.HRCT findings showed that most lesions were in two lungs (81.3%), which mainly distributed in the middle and outer zone of the two lungs and the subpleural area (96.7%), and most commonly in the left lower lobe (90.6%).Most of the lesions were patchy (84.6%) and irregular (76.9%), the common lesions were ground-glass shadow (80.3%), ground-glass shadow with consolidation (62.5%), complete consolidation (43.8%), thickening of interlobular septum (71.9%), thickening of bronchovascular bundle (68.8%), paving stone sign (43.8%), vacuole/cavity shadow (28.1%) and so on, severe patients could develop "white lung"(3.1%). ConclusionsThe clinical and imaging features of COVID-19 have certain characteristics and reference value, but it still needs to be considered comprehensively in combination with epidemiology and laboratory indicators.
2020, 45(2): 154-155.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.004
Abstract:
ObjectiveTo investigate the efficacy of lopinavir/ritonavir for the treatment of corona virus disease 2019 (COVID-19). MethodsA total of 60 patients with COVID-19 were divided into two groups (30 cases in each group).The control group was treated with Lianhua Qingwen capsule and interferon-α, and the observation group was treated with lopinavir/ritonavir on the basis of control group.The therapeutic efficacy of two groups was compared. ResultsIn observation group, 13 cases were with notable therapeutic efficacy, and 10 cases with partially effective efficacy; in control group, 3 cases were with notable therapeutic efficacy, and 11 cases with partially effective efficacy.The effective rate of treatment in observation group (76.67%) was significantly higher than that in control group (46.67%) (P < 0.01). ConclusionsLopinavir/ritonavir is effective for the treatment of COVID-19.
2020, 45(2): 156-159.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.005
Abstract:
ObjectiveTo evaluate the clinical value of the first chest CT manifestations for suspected imported corona virus disease 2019 (COVID-19). MethodsThe first CT manifestations and clinical data of 34 patients with suspected imported COVID-19 were analyzed retrospectively.The difference of the onset time of patients at different stages confirmed by CT was compared by the two independent samples t-test, and the difference between the chest CT and one-time nucleic acid test for the diagnosis of imported COVID-19 was compared by Fisher's accurate probability method. ResultsIn the 34 suspected cases, 31 cases were found with COVID-19, and 3 cases with other types of pneumonia (including 1 case of influenza A virus pneumonia, 1 case of influenza B virus pneumonia and 1 case of influenza A and B mixed? virus pneumonia).In the 31 COVID-19 cases, 30 cases were positive and 1 case was negative by chest CT.Chest CT showed 21 cases were at early stage, 9 cases at progressive stage, 0 case at severe stage.The onset time of patients in progressive stage group[(6.50±1.90)]d was longer than that in early stage group [(2.32±1.13)]d (P < 0.01).Three cases with other pneumonia showed bilateral pulmonary scattered ground-glass shadows, some of which showed consolidation.Twenty-three cases were confirmed by one-time SARS-CoV-2 nucleic acid test, and 8 cases were confirmed by two or more times of nucleic acid test.The positive rate of characteristic chest CT manifestations was higher than that of one-time nucleic acid test in the diagnosis of imported COVID-19 (P < 0.05). ConclusionsAlthough the chest CT manifestations of imported COVID-19 are various, there still are certain characteristics, most of these are multiple ground-glass shadows and partial consolidation under the pleura of both lungs, and the lesions at progressive stage fuse with each other.For suspected cases, the positive rate of characteristic chest CT manifestations is higher than that of one-time nucleic acid test, and those with characteristic CT manifestations in special period should be treated as confirmed cases.
2020, 45(2): 159-162.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.006
Abstract:
ObjectiveTo investigate the current mental health status of people in Bengbu affected by corona virus disease 2019 (COVID-19) epidemic, to provide a reference for relevant departments to improve mental health service, and to supply basis to conduct psychological intervention in the present and future. MethodsThe questionnaire of the public mental health during COVID-19 epidemic was made online, and the subjects were invited to fill in the questionnaire by Wechat forwarding. ResultsThe effective response rate was 100% (343/343).The subject who understood the development of COVID-19 epidemic accounted for 90.67%, who understood COVID-19 accounted for 87.17%, who wore mask in public place accounted for 99.42%, who estimated that COVID-19 would be basically controlled within three months accounted for 72.3%, who believed that the current measures were effective accounted for 87.18%, who thought that the home was the safest place during the period of COVID-19 epidemic accounted for 90.67%, and who knew that concealing the contact history of COVID-19 was illegal accounted for 65.31%.In the 20 items of the self-assessment questionnaire of mental health, the top three with the highest detection rate were easy fatigue (34.69%), unhappiness (29.45%) and difficulty to make decision (28.28%).In subjects of different genders, females who felt "nervous, uneasy or worried", and "cried much more than before" were more than male (P < 0.05).In subjects of different occupations, non-medical staffs who felt "that it was difficult to have fun from daily activity", and "had the thought of ending own life" were more than medical staffs (P < 0.05).Sixty cases had the questionnaire SRQ-20 score ≥7 points. ConclusionsAfter COVID-19 occurence, the government and society's vigorous publicity to the public has achieved good results.The public pays more attention to COVID-19, has a better understanding of the disease, and can take effective measure, so the majority of the public has good mental health.Psychological intervention should be strengthened, especially the acute stress response of women and some non-medical staffs.
2020, 45(2): 163-166.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.007
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ObjectiveTo explore the culture of human eye trabecular meshwork cells in vitro, and establish a new method of identifying cells according to its characters. MethodsThe trabecular meshwork tissue was isolated from the eyeballs of patients with ocular rupture injury, and corneal ring left after corneal transplantation, and the human primary trabecular meshwork cells were cultured in vitro using tissue block adherence and digestion methods.The cell growth was observed under an inverted microscope, and the growth rate was measured using CCK8.The fiber connection protein, type Ⅳ collagen protein, layer adhesion protein and water channel protein-1 were identified using cell immunofluorescence staining.The cultured cells were induced using 100 nml/L of dexamethasone for 10 d, and the mRNA and protein expression levels of myocilin were detected using fluorescence quantitative PCR and western blotting, respectively. ResultsAfter culturing for 1 to 2 weeks, the cells began to grow out from the side of the trabecular meshwork, and gradually increased.After passaging, the trabecular meshwork cells grew faster on 1-4 days, and slower on 5-7 days, which still significantly higher than that on day 4(P < 0.01).The staining of fibronectin, collagen-Ⅳ, laminin and aquaporin 1 in cultured cells were positive using immunofluorescence.After dexamethasone inducing, the myocilin mRNA and protein expression levels in trabecular meshwork cells significantly increased compared with the control group(P < 0.01). ConclusionsThe primary trabecular meshwork cells can be identified by detecting their characteristics.
2020, 45(2): 167-170.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.008
Abstract:
ObjectiveTo investigate the effects of atmospheric fine particulate matters(PM)2.5 on TLR4 expression and oxidative stress levels in THP1 macrophages. MethodsThe THP1 macrophages from Beijing China and Baltimore United States were stimulated by PM2.5 for 24 h.The expression levels of TLR4 and Nrf2 in macrophages and degree of intracellular reactive oxygen species(ROS) production were detected. ResultsThe expression levels of TLR4 and Nrf2 and degree of intracellular ROS production significantly increased after low concentration(50 μg/mL) PM2.5 from Beijing and Baltimore stimulating for 24h compared with the control group(P < 0.05).Compared with the control group, after the cells were stimulated using high concentration(200μg/mL) PM2.5 from Beijing and Baltimore for 24 h, the expression levels of TLR4 and Nrf2 decreased, the intracellular ROS production in Beijing area decreased(P < 0.05), and the intracellular ROS production in Baltimore increased(P < 0.05). ConclusionsThe low concentration of PM2.5 can promote the expression of TLR4 in macrophages, and increase the level of oxidative stress.The high concentration of PM2.5 can reduce the expression of TLR4 and level of oxidative stress in macrophages.
2020, 45(2): 170-173.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.009
Abstract:
ObjectiveTo observe the effects of Biling Qutong prescription(Biling prescription) on the levels of high mobility group B1(HMGB1) and FOXO3 in kidney of diabetic gout model rats. MethodsForty healthy rats were divided into the normal control group, model group, Biling group, indomethacin group and pioglitazone group(8 rats in each group).Except the normal control group, the other groups were fed with high-fat diet combined with low-dose streptozotocin 35 mg/kg once a day, and the blood glucose ≥"16.7 mmol/L was set as the standard of the diabetes model.After 4 days, the 0.9% sodium chloride solution was injected into the joint cavity of rats to establish the gout model.After the model was successfully established, the Biling group, indomethacin and pioglitazone group were continuously treated with relative drug for 21 days.The normal control group and model group were given the same amount of 0.9% sodium chloride solution.After 21 days, the levels of blood glucose, uric acid and blood uric acid, and expression levels of HMGB1 and FOXO3 in kidney were detected. ResultsCompared with the normal control group, the levels of blood glucose, serum uric acid, triacylglycerol(TG), total cholesterol (TC), low-density lipoprotein cholesterol(LDL-C) significantly increased(P < 0.01), and the expression levels of HMGB1 and FOXO3 in kidney significantly increased in model group(P < 0.01).Compared with the model group, the levels of blood glucose and serum uric acid decreased, and the expression levels of HMGB1 and FOXO3 in kidney significantly decreased in Biling group, indomethacin and pioglitazone group(P < 0.05 to P < 0.01).Compared with the model group, the levels of TG, TC and LDL-C in Biling group and pioglitazone group decreased(P < 0.05 to P < 0.01), and the levels of TC and LDL-C in indomethacin group decreased(P < 0.05 and P < 0.01). ConclusionsBiling prescription has good effects in lowering blood glucose, regulating lipid and lowering blood uric acid, the action mechanism of which may be related to the intervention of the high expression of HMGB1 and FOXO3 in kidney of diabetic gout rats, and which is of great significance for the prevention and treatment of kidney disease induced by diabeticgout.
2020, 45(2): 174-177, 180.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.010
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ObjectiveTo investigate the mechanism of recombinant human endostatin(rhEndostatin) promoting the apoptosis of hypertrophic scar fibroblast(HSFs) in rabbit ear, and provide the experimental basis for clinical drug treatment of hypertrophic scar(HS). MethodsThe HS model was prepared in 6 healthy New Zealand white albino rabbits.The effects of rhEndostatin(100 μg/mL) on the intracellular Ca2+ concentration([Ca2+] i) of HSFs in Hanks and D-Hanks fluids(with and without extracellular calcium) were detected using laser confocal microscopy(CLSM) combined with Fluo-4 /AM(Ca2+ fluorescence indicator). ResultsWhen the extracellular fluid was the Hanks fluid, the rhEndostatin could cause the HSFs [Ca2+]i increasing, and the levels of [Ca2+]i reached to peak after 10 s of treatment, then slowly decreased with time.After stopping the drug treatment, the levels of [Ca2+]i continued to slow down, and the level of HSFs [Ca2+]i did not return to baseline after 50 s of rhEndostatin withdrawal.HSFs [Ca2+]i was not affected by rhEndostatin when the cells were incubated with D-Hanks buffer. ConclusionsRhEndostatin can induce the HSFs apoptosis by interfering with intracellular Ca2+ homeostasis and promoting extracellular Ca2+ influx to cause intracellular calcium overload.
2020, 45(2): 178-180.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.011
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ObjectiveTo establish the rat model of chronic intermittent hypoxia, and detect the expression level of endoplasmic reticulum stress marker protein CHOP in lung tissue of chronic intermittent hypoxia rats. MethodsForty-eight male Wistar rats were randomly divided into the chronic intermittent hypoxic(CIH) group and control(UC) group.Each group was subdivided into 4 subgroups, including 1 week, 2 weeks, 3 weeks and 4 weeks subgreups(6 rats in eech subgroup).The histopathological changes of lung tissue and expression level of CHOP protein in CIH group and UC group were analyzed using HE staining and immunohistochemistry. ResultsIn CIH group, the alveolar structure was destroyed, the alveolar wall septum widened, the interstitial edema was seen, a small amount of inflammatory cells infiltrated, and the partial alveolar fused.No obvious pathological change was found in the UC group.The results of immunohistochemistry showed that the expression level of CHOP protein in CIH group rats was significantly higher than that in UC group, and the CHOP expression increased with the duration of hypoxia(P < 0.01). ConclusionsThe expression of CHOP in lung tissue of chronic intermittent hypoxia rats increases.
2020, 45(2): 181-184.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.012
Abstract:
ObjectiveTo investigate the expression level, function and possible molecular mechanism of microRNA (miR)-655 in epithelial ovarian cancer. MethodsThe expression levels of miR-655 in 40 cases of epithelial varian cancer tissues and normal tissues were detected using real-time quantitative-PCR, and the relationship between miR-655 expression and clinicopathological features was analyzed.The cell counting Kit-8(CCK-8) and flow cytometry were used to detect the effects of miR-655 on the proliferation and apoptosis of ovarian cancer cells.Western blotting was used to detect the expression of PI3K, AKT and mTOR. ResultsThe expression level of miR-655 in epithelial ovarian carcinoma was significantly lower than that in normal tissues(P < 0.01).The differences of the expression levels of miR-655 among patients with different tumor diameter, degree of pathological differentiation and lymph node metastasis were statistically significant(P < 0.05 to P < 0.01), and the differences of the expression levels of miR-655 among patients with different ages and CA-125 were not statistically significant(P>0.05).The transfection of miR-655 mimics could significantly inhibit the proliferation and promote apoptosis of ovarian cancer cells(P < 0.01).The transfection of MiR-655 mimics significantly could significantly inhibit the expression of PI3K, AKT and mTOR in ovarian cancer cells(P < 0.01). ConclusionsThe low expression of miR-65 in ovarian cancer tissue is significant, which may be related to the growth and differentiation of ovarian cancer.miR-655 can significantly inhibit the proliferation and induce apoptosis of ovarian cancer cells.miR-655 has a certain value of target therapy in ovarian cancer patients.
2020, 45(2): 185-188.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.013
Abstract:
ObjectiveTo investigate the changes of serum levels of cystatin C and uric acid in patients with Parkinson's disease(PD), and analyze the correlation of serum levels of cystatin C and uric acid with cognitive impairment. MethodsSixty patients with PD and 30 cases healthy examiners matched for gender and age were divided into the observation group(PD group) and control group, respectively.The PD group were subdivided into the PD complicated with cognitive impairment group and PD complicated without cognitive impairment group according to the mini-mental State Examination(MMSE) score.The serum levels of cystatin C and uric acid in all groups were measured. ResultsThe serum levels of cystatin C and uric acid in PD group were higher and lower than those in control group, respectively(P < 0.05 and P < 0.01).The serum levels of cystatin C and uric acid in PD complicated with cognitive impairment group were higher and lower than those in PD complicated without cognitive impairment group, respectively(P < 0.01 and P < 0.05).The serum level of cystatin C was negatively correlated with MMSE score(P < 0.01), and the serum level of uric acid was positively correlated with MMSE score(P < 0.05). ConclusionsThe serum levels of cystatin C and uric acid are correlated with PD complicated with cognitive impairment, which can be used as an early biological evaluation index in PD complicated with cognitive impairment.
2020, 45(2): 188-191.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.014
Abstract:
ObjectiveTo explore the clinical effects of different operative timing on postoperative outcome of femoral intertrochanteric fracture in elderly patients. MethodsSeventy-eight femoral intertrochanteric fracture patients treated with proximal femoral nail antirotation(PFNA) internal fixation were divided into the observation group and control group.The operations in observation group and control group were performed within 48 h and after 48 h of fracture, respectively.The operative time, intraoperative blood loss, hospitalization time, hospitalization expense, postoperative hip function score(Harris score) and incidence rate of postoperative complication between two groups were compared. ResultsThe hospitalization time and expense in observation group were significantly less than those in control group(P < 0.01).There was no statistical significance in the operative time, intraoperative blood loss and incidence rate of postoperative complication between two groups(P>0.05).The differences of the good rates of the recovery of hip joint function between two groups were not statistically significant after 1, 3 and 6 months of operation(P>0.05). ConclusionsThe operation effects within 48 h and after 48 h of femoral intertrochanteric fracture in elderly patients are the same, which can shorten the hospitalization time, and reduce the economic burden of patients.
2020, 45(2): 192-196.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.015
Abstract:
ObjectiveTo analyze the related factors of the minimal clinically important difference(MCID) in healthrelated quality of life score after isthmic spondylolisthesis(IS). MethodsA total of 74 low-grade IS patients treated with transforaminal lumbar interbody fusion (TLIF) internal fixation fusion were investigated, and followed up for 24 to 49 months.The postoperative Oswestry disability index(ODI) improvement >12 scores and visual analogue scale(VAS) score of lower back pain and leg pain improvement >3 scores were defined as the MCID.The patients were divided into MCID group(group A) and no reaching MCID group(group N) according to the improvement scores of the above items.The general data, imaging parameters and postoperative complications were compared between two groups. ResultsThe proportions of the improvement scores of ODI, VAS back pain and VAS leg pain achieving the MCID were 81.1%, 79.7% and 73.0%, respectively.The differences of the age and sex in different scores of ODI, VAS back pain and VAS leg pain between two groups were not statistically significant(P>0.05).Under the VAS score of low back pain, the difference of operative segment between two groups was not statistically significant(P>0.05), and under the ODI and VAS leg pain score, the difference of operative segment between two groups was statistically significant(P < 0.05).There was no statistical significance in preoperative imaging parameters between two groups(P>0.05).After surgery, the disc height in group A was higher than that in group N(P < 0.05), and the segmental lordosis in group A was lower than that in group N(P < 0.05).Under the ODI score, the segmental lordosis in group A was lower than that in group N(P < 0.05).There was no statistical significance in other imaging parameters between two groups(P>0.05).There was no statistical significance in the incidence of complications between two groups(P>0.05). ConclusionsFor low-grade IS patients treated with TLIF, The appropriate disc height reconstruction may be more significant than achieving greater segmental lordosis or increasing reduction rate for low-grade IS patients.
2020, 45(2): 197-200.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.016
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ObjectiveTo investigate the drug resistance of Acinetobacter baumannii caused ventilator-associated pneumonia(VAP), and risk factors of VAP. MethodsThe patients treated with mechanical ventilation from ICU were investigated.Thirty Acinetobacter baumannii infection patients and 30 patients without VAP were divided into the observation group and control group, respectively.The drug resistance of Acinetobacter baumannii and risk factors of VAP were analyzed. ResultsThe drug resistance rates of Acinetobacter baumannii isolated to amikacin, piperacillin/tazobactam were relatively low, which was 53.3% and 66.6%, respectively.The drug resistance rates of Acinetobacter baumannii to cefazoline, ampicillin, aztreonam, nitrofurantoin and cefotetan were more than 90%, the drug resistance rate of Acinetobacter baumannii to imipenem reached 80%, and the drug resistance rates of Acinetobacter baumannii to other antimicrobia resistance were greater than 70%.The results of univariate analysis showed that the differences of drug resistance in length of hospital stay, mechanical ventilation mode, mechanical ventilation duration, using more than 3 combination of antibiotics before infection, using carbapenems before infection and using enteral nutrition were statistically significant(P < 0.01).The results of logistic analysis showed that the hospitalization time≥14 days, tracheotomy and mechanical ventilation time≥5 days were the independent risk factors of the incidence of Acinetobacter baumannii caused VAP. ConclusionsThe drug-resistance of Acinetobacter baumannii isolated froun Acinetobacter baumannii caused VAP to antibacterial agents is higher.The antibiotics should be reasonably selected, and the management of nosocomial infection should be strengthened according to the related risk factors.
2020, 45(2): 201-204.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.017
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ObjectiveTo investigate the correlation of the polymorphism of fibrinogen(Fg)Bβ-249C/T gene with chronic obstructive pulmonary disease(COPD) and smoking. MethodsEighty patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD) and 100 healthy subjects were divided into the case group and control group, respectively.The level of Fg, and levels of IL-8 and TNF-α was detected using the enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay, respectively.The polymorphism of FgBβ-249C/T gene was analyzed using polymerase chain reaction restriction fragment length polymorphism analysis technique, and the mutation rate of gene was calculated. ResultsThere was genetic polymorphism in FgBβ-249C/T locus.The levels of Fg, IL-8, TNF-α, gene mutation ratio of FgBβ-249C/T locus and type CT+TT Fg level in smokers were significantly higher than those in nonsmokers in two groups(P < 0.01), and the levels of Fg, IL-8, TNF-α, gene mutation ratio of FgBβ-249C/T locus and type CT+TT Fg level in smokers of case group were significantly higher than those in smokers of control groups(P < 0.01). ConclusionsSmoking is associated with the FgBβ-249C/T gene polymorphism and COPD.The selective polymorphism detection of the selective FgBβ-249C/T gene locus may help to screen COPD.
2020, 45(2): 204-206.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.018
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ObjectiveTo analyze the early warning effects of serum vitamin D binding protein(DPB) during the treatment of acute pancreatitis, analyze the possible mechanism for providing a reference in the improvement of acute pancreatitis treatment regimen. MethodsEighty-six acute pancreatitis patients were divided into the mild group(31 cases), moderate group(30 cases) and severe group(25 case) according to the severity of disease at the time of visit, and 30 healthy people was set as the control group.The DPB at different time periods after treatment were compared among four groups.The degree of organ failure in severe pancreatitis patients or mild and moderate transforming into severe acute pancreatitis patients were evaluated using modified Marshall scoring system, and the DPB levels in different scores patients were compared. ResultsAmong the acute pancreatitis patients, the DPB level in severe group was significantly lower than that in control group(P < 0.05), and the differences of the DBP levels between the mild and moderate groups, and control group were not statistically significant(P>0.05).The levels of DBP in mild group after 1 and 2 weeks of treatment were higher than that before treatment(P < 0.05 and P < 0.01), and the levels of DBP in moderate and severe groups after 2 weeks of treatment were higher than that before treatment(P < 0.05).The DBP level of patients with Marshall scores 3-4 after 2 weeks of treatment was higher than that of patients with Marshall score 0(P < 0.05). ConclusionsThe serum level of DPB in acute pancreatitis patients is related to the disease progression, which plays certain role in early warning and has clinical value for further research.
2020, 45(2): 207-210.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.019
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ObjectiveTo investigate the clinical application effects of the pump injection of dexmetomidine(DEX) combined with remifentanil and propofol in intraoperative nerve monitoring(IONM) during thyroidectomy. MethodsSeventy thyroidectomy patients with IONM were randomly divided into the observation group and control group(35 cases in each group).The observation group was induced by intravenous pumping 0.6 g/kg DEX for the first 10 min, followed by continuous pumping 0.4 μg·kg-1·h-1 DEX, and the drug stopped before 30 min of the end of the surgery.The control group was injected with the same amount of 0.9% sodium chloride solution.Two groups were rapidly induced using the 0.05 mg/kg midazolam, 2 mg/kg propofol, 0.4 μg/kg remifentanil and 0.3 mg/kg rocuronium bromide, and a special nerve catheter was inserted into the patient.Remifentanil and propofol were pumped intraoperatively to maintain anesthesia without muscle relaxants.The heart rate(HR), mean arterial pressure(MAP) and bispectral(BIS) index in two groups were recorded before injection(T0), before anesthesia induction(T1), and at the time of intubation(T2), cutting skin(T3) and isloating thyroid gland(T4) and extubation(T5).The dosage of propofol and remifentanil, recovery of anesthesia, postoperative comfort and intraoperative awareness were recorded in two groups. ResultsThe HR and MAP in observation group at T1 to T4 were lower than those at T0(P < 0.05 to P < 0.01), and the BIS in observation group at T1 to T5 were significantly lower than that at T0(P < 0.01).The HR in control group at T3 and T4 were lower than that at T0(P < 0.05), and the BIS in control group at T2 to T5 were significantly lower than that at T0(P < 0.01).The HR and MAP in observation group at T1 to T4 were significantly lower than those in control group at each time-point(P < 0.05 to P < 0.01), and the BIS in observation group at T1 was significantly lower than that in control group(P < 0.01).Neither group had intraoperative knowledge.The dosage of propofol and remifentanil in observation group were significantly lower than those in control group(P < 0.01).The incidence rate of restlessness in observation group(5.71%)(2/35) was lower than that in control group(25.71%)(9/35)(P < 0.05).The BCS score in observation group after operation was significantly higher than that in control group(P < 0.01).The differences of the opening eye time and extubation time were not statistically significant between two groups(P>0.05). ConclusionsThe application of DEX combined with remifentanil and propofol in thyroidectomy does not affect the IONM, can meet with operation, reduce restlessness during recovery and improve postoperative comfort.
Expression levels of SPINK1 and Vimentin in non-small cell lung cancer and its clinical significance
2020, 45(2): 211-214.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.020
Abstract:
ObjectiveTo explore the expression levels of serine protease inhibitor Kazal 1(SPINK1) and Vimentin in non-small cell lung cancer(NSCLC) and its clinical significance. MethodsThe expression levels of SPINK1 and Vimentin in 136 cases of NSCLC tissue and 62 cases of normal lung tissue were detected using the immunohistochemical SP method, and the data was analyzed using univariate Kaplan-Meier survival analysis and multivariate Cox regression analysis. ResultsThe positive rates of SPINK1 and Vimentin expression in 136 cases of NSCLC tissue and 62 cases of normal tissues were [65.4%(89/136) and 52.9%(72/136)] and [4.8%(3/62) and 3.2%(2/62)], respectively, and the differences of which were statistically significant(P < 0.01).The differences of the expression levels of SPINK1 and Vimentin in NSCLC tissues with different TNM stages and lymph node metastasis were significantly significant(P < 0.05 to P < 0.01), and the difference of the expression level of SPINK1 in NSCLC tissues with different differentiation degrees was significantly significant(P < 0.05).The expression level of SPINK1 was positively correlated with Vimentin in NSCLC tissue(rs=0.368, P < 0.01).The results of multivariate Cox regression analysis showed that the TNM stage, lymph node metastasis, and expression levels of SPINK1 and Vimentin were the independent influencing factors of NSCLC prognosis(P < 0.05 to P < 0.01). ConclusionsSPINK1 and Vimentin possibly play a role in the development, invasion and metastasis of NSCLC, and SPINK1 may act as a new indicator in predicting the prognosis of NSCLC.
2020, 45(2): 215-218.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.021
Abstract:
ObjectiveTo analyze the clinical characteristics and influencing factors of short-term prognosis in 67 patients with acute superior mesenteric venous thrombosis(ASMVT) for providing the reference in improving the prognosis of patients. MethodsThe baseline data of 67 patients with ASMVT in our hospital from 2004 to 2016 were retrospectively analyzed.The clinical features among the patients with different treatment methods and lesion locations were compared.The patients were divided into the survival group and death group according to the prognosis, and the prognostic factors were analyzed using the univariate and multivariate logistic regression method. ResultsAmong 67 cases with ASMVT, 8 cases died, and 59 cases survived.The ratios of peritoneal irritation, laparotomy and intestinal necrosis in isolated ASMVT group were significantly higher than that in combined ASMVT group(P < 0.05 to P < 0.01).The ratios of splenectomy in isolated ASMVT group were lower than that in combined ASMVT group(P < 0.05).The ratios of isolated ASMVT and death in open surgery group were significantly higher than those in interventional therapy group(P < 0.01).The time from onset to treatment of interventional therapy group was significantly higher than that in open surgery group and conservative treatment group(P < 0.05 to P < 0.01).The splenectomy, liver cirrhosis, hypersplenism, severe pancreatitis, venous thrombosis history, time from onset to treatment, duration of anticoagulant therapy less than 6 months, lesion location and intestinal necrosis could obviously affect the prognosis of patients with ASMVT(P < 0.05 to P < 0.01).The splenectomy, liver cirrhosis, hypersplenism, severe pancreatitis and duration of anticoagulant therapy less than 6 months were the independent risk factors of death in patients with ASMVT(P < 0.05 to P < 0.01). ConclusionsThe combined ASMVT is easy to be found after splenectomy, and the ratio of open surgery, intestinal necrosis and higher peritoneal irritation in isolated ASMVT patients are high.The splenectomy, liver cirrhosis, hypersplenism, severe pancreatitis and duration of anticoagulant therapy less than 6 months are the main influencing factors of prognosis in patients with ASMVT.
2020, 45(2): 219-222.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.022
Abstract:
ObjectiveTo investigate the etiology characteristics and drug resistance of stroke associated pneumonia(SAP) for providing the reference in antimicrobial agents rational use. MethodsThe sputum culture data in 161 SAP patients were analyzed, the type of stroke was divided into the ischemic stroke and hemorrhagic stroke, and classified according to the mechanical ventilation.The detection rate of pathogen and drug sensitive test were analyzed. ResultsAmong 161 SAP patients, 176 strains bacteria were detected, which included G--bacteria(70.45%), G+-bacteria(7.39%) and fungi(22.16%).The G--bacteria mainly included Klebsiella peneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and E.coli.Twenty-six extended-spectyum β-lactamase strains were detected, which included 10 strains of E.coli and 16 strains of K.pneumoniae.The G+-bacteria mainly included Staphylococcus aureus, and the methicillin-resistant staphylococcus was not detected.Fungus was mainly Canidia albicans.Drug susceptibility test results showed that the G--bacteria was more sensitive to amikacin and piperacillin-tazobactam, the G+ -bacteria was more sensitive to vancomycin and linezolid.Among 161 SAP cases, the ischemic stroke in 63 cases and hemorrhagic stroke in 98 cases were identified.One hundred cases treated with mechanical ventilation and 61cases treated without mechanical ventilation were found.The difference of the pathogenic bacteria composition between ischemic stroke and hemorrhagic stroke patients was statistically significant(P < 0.01 and P < 0.05). ConclusionsThe G--bacteria is mainly pathogenic bacteria of SAP, and the fungi infection and mixed infection with fungi increase gradually.Different type stroke and mechanical ventilation affect the the pathogenic bacteria composition of SAP, and the rational use of antimicrobial agents should be in accordance with the etiology characteristics of sputum culture.
2020, 45(2): 223-226.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.023
Abstract:
ObjectiveTo investigate the effects of vacuum sealing drainage(VSD) technique combined with epidermal growth factor(EGF) in the treatment of deep burn. MethodsOne hundred patients with deep burn were randomly divided into the control group and observation group(50 cases each group).The wound in two groups was cleaned, and closed with VSD device.The control group was treated with normal saline, and the observation group was treated with EGF solution washing suction device.The wound healing and inflammatory reaction condition were compared between two groups. ResultsAfter 5 d of treatment, there was no statistical significance in the wound healing rate between two groups(P>0.05), and the levels of interleukin-1 and tumor necrosis factor-α, noradrenaline, epinephrine and rennin in observation group were significantly lower than those in control group(P < 0.01).The wound healing rates in two groups significantly increased after 10 d and 15 d of treatment, and which in observation group was higher than that in control group(P < 0.05).The wound healing time, number of scar healing cases and infection cases in observation group were significantly lower than those in control group(P < 0.05 to P < 0.01). ConclusionsVSD technique combined with EGF can promote the wound healing in patients with deep burn, improve the healing effect, reduce the patient's inflammatory stress reaction, which is worthy of clinical promotion.
2020, 45(2): 226-229.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.024
Abstract:
ObjectiveTo investigate the effects of titanium porcelain crown and cobalt-chromium alloy porcelain crown on periodontal tissue around the implant. MethodsNinety-seven patients treated with single tooth implant restoration in maxillary anterior teeth region were divided into the titanium group(n=51) and cobalt-chromium alloy group(n=48) according to the differences of restorative material.Before preparation of the implant(T0), after 1 month(T1), 3 months(T2), 6 months(T3) and 12 months(T4) of porcelain crowns bonding, the periodontal indicators were tested, respectively.The gingival crevicular fluid surrounding implant tissues were extracted from T0 to T4, respectively, and the levels of malondialdehyde(MDA), superoxide dismutase(SOD), glutathione S-transferase(GST), and interleukin 6(IL-6) in gingival crevicular fluids were detected. ResultsCompared with T0, the gingival index(GI) and gingival sulcus exploration depth(PD) in two groups increased(P < 0.01), and the content of gingival crevicular fluid in cobalt-chromium alloy group at T2 to T4 increased(P < 0.05).The differences of the content of gingival crevicular fluid in titanium group among T1-T3 and T4 were not statistically significant(P>0.05).The GI, PD and gingival crevicular fluid in titanium group at T2 to T4 were lower than those in cobalt-chromium alloy group(P < 0.05 to P < 0.01).Compared with T0, the levels of MDA and IL-6 in gingival crevicular fluid in two groups at T3 to T4 increased, while the levels of SOD and GST decreased(P < 0.05 to P < 0.01).The levels of IL-6 in gingival crevicular fluid at T3 to T4 in titanium group were lower than those in cobalt-chromium alloy group, but the levels of GST were higher than those in cobalt-chromium alloy group(P < 0.05 to P < 0.01). ConclusionsAs time going, both titanium porcelain crown and cobalt-chromium alloy porcelain crown can affect the periodontal tissue, but the effect of titanium porcelain crown is weaker than that of cobalt-chromium alloy porcelain crown.
2020, 45(2): 235-237.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.027
Abstract:
ObjectiveTo explore the application value of ultrafast pulse wave velocity(UFPWV) in quantitative evaluating the early changes of carotid artery structure and function in patients with Graves disease(GD). MethodsSeventy-six GD patients without intima-media thickness(IMT) of carotid artery thickening and 76 healthy people were divided into the GD group and control group, respectively.The carotid IMT in two groups was measured.The pulse wave conduction velocity was recorded using the UFPWV technology, and which included the pulse wave conduction velocity at the beginning and end of systole(BS and ES).The related parameters were compared, and the correlation of BS and ES with IMT, thyroid volume and serum thyroid hormone level were analyzed. ResultsThere was no statistical significance in IMT between GD group and control group(P>0.05), and the BS and ES in GD group were significantly higher than those in control group(P < 0.01).The BS and ES of vascular elasticity parameters were not correlated with the thyroid volume(P>0.05), but were positively correlated with IMT(P < 0.01).The ES was positively correlated with the level of free triiodothyronine. ConclusionsThe early changes of carotid artery elasticity in patients with GD before IMT thickening can be detected by UFPWV, which can be used as a new effective method to evaluate the artery elasticity in patients with GD.
2020, 45(2): 238-241.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.028
Abstract:
ObjectiveTo explore the application value of virtual touch tissue quantification(VTQ) and virtual touch tissue imaging quantification(VTIQ) in the differential diagnosis of benign and malignant breast nodules. MethodsFifty-eight breast solid nodules in 58 patients with breast disease were collected.The internal shear wave velocity value (SWV) of the nodules were measured using VTQ and VTIQ techniques before operation or before biopsy, and the results of which were compared with the pathological results.The ROC curve of benign and malignant breast nodules diagnosed by VTQ and VTIQ techniques were drew to compare the diagnostic efficacy of two techniques. ResultsFifty-eight breast nodules included 24 malignant nodules and 34 benign nodules.The mean value of SWV measured by VTQ and VTIQ in malignant nodules was significantly higher than that in benign nodules(P < 0.01).For benign and malignant breast nodules, there was no statistical significance in the SWV value measured by VTIQ and VTQ(P>0.05).The area under ROC curve of VTIQ technique(0.820) was higher than that of VTQ technique(0.702)(P < 0.05).The best threshold of SWV value in benign and malignant nodules diagnosed by VTQ technique was 3.97 m/s.With 3.97 m/s as cut-off point, the sensitivity, specificity and accuracy of differential diagnosis of benign and malignant nodules were 66.7%, 70.6% and 69.0%, respectively, and the AUC was 0.702.The optimal threshold of SWV value diagnosed by VTIQ was 4.09 m/s.With 4.09 m/s as the cut-off point, and the sensitivity, specificity and accuracy were 79.2%, 85.3% and 82.8%, respectively, and the AUC was 0.820. ConclusionsThe efficacy of VTIQ technique is superior to VTQ in the differential diagnosis of benign and malignant breast nodules, and the VTIQ technique has a better clinical application prospect.
2020, 45(2): 242-245.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.029
Abstract:
ObjectiveTo explore the correlation between inteavoxel incoherent motion(IVIM) parameters and histologic type and pathological grade of rectal cancer. MethodsTwenty-nine patients with common adenocarcinoma of rectum and 12 patients with mucinous adenocarcinoma diagnosed by pathology were divided into the common group and mucinous group, respectively.Two groups were detected using routine MR and IVIM scan(b=0, 10, 20, 50, 100, 200, 400, 800, 1 200, 2 000 s/mm2) before operation.The apparent diffusion coefficient(ADC), true diffusion coefficient(D), pseudo-diffusion coefficient(D*) and perfusion score(f value) were compared between two groups.The diagnostic efficiency of parameters were evaluated using receiver operating characteristic curve(ROC). ResultsThe ADC, D and f value in common group were significantly lower than that in mucinous group(P < 0.01).The differences of the ADC, D and f value in different pathology grades patients in common group were not statistically significant(P>0.05).The results of ROC analysis showed that the optimal threshold value, sensitivity, specificity and area under the curve ROL in common adenocarcinoma of rectum patients and mucinous adenocarcinoma diagnosed by the ADC, D and f value were 0.998×103 mm2/s, 88.3%, 55.7%, 0.748, 0.81×10-3 mm2/s, 91.7%, 72.9%, 0.814, 43.0%, 75.0%, 72.9% and 0.758, respectively. ConclusionsIVIM parameter can quantitatively reflect the characteristics of cell density and perfusion of different histological types of rectal cancer.The D value has the highest diagnostic efficiency, which is helpful for preoperative prediction and making of clinical treatment plans.
2020, 45(2): 246-248.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.030
Abstract:
ObjectiveTo analyze the diagnosis value of the combined detection of Golgi protein 73(GP73), serum ferritin(SF) and α-fetoprotein(AFP) in patients with primary hepatocellular carcinoma. MethodsSeventy-two patients with primary hepatocellular carcinoma and 60 healthy people were divided into the observation group and control group, respectively.The levels of GP73, SF and AFP in two groups were detected, the correlation among three indexes and incidence of primary hepatocellular carcinoma was analyzed using logistic regression analysis.The sensitivity and specificity of separate and combinde detection of three indexes were compared. ResultsThe levels of GP73, SF and AFP in observation group were significantly higher than those in control group(P < 0.01).The results of regression analysis showed that high levels of GP73, SF and AFP were the risk factors of primary hepatocellular carcinoma(P < 0.05 to P < 0.01).The sensitivity and specificity of GP73, SF and AFP in detecting primary hepatocellular carcinoma were(69.44%, 66.67% and 70.83%) and(96.67%, 91.67% and 95.00%), respectively.The sensitivity and specificity of the combined detection were 98.61% and 83.33%, respectively, which was higher and lower than that in alone index detection, respectively. ConclusionsGP73, SF and AFP are important serological markers in the diagnosis of primary hepatocellular carcinoma.The combined detection of GP73, SF and AFP significantly improve the sensitivity and specificity of diagnosis compared with the alone index detection.
2020, 45(2): 249-251.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.031
Abstract:
ObjectiveTo explore the clinical significance of the coagulation parameters, D-dimer (DD) and plasma fibrinogen degradation product(FDP) levels in patients with fractures. MethodsA total of 57 fracture patients and 68 healthy people were divided into the observation group and control group, respectively.The prothrombin time(PT), activated partial prothrombin time(APTT) and thrombin time(TT), and levels of fibrinogen(Fg), DD and FDP were compared between two groups.Among the patients in observation group with different types of fractures, the positive rates of Fg, DD and FDP, levels of Fg, DD and FDP in patients with and without deep vein thrombosis(DVT) were compared. ResultsThe levels of Fg, DD and FDP in observation group were significantly higher than those in control group(P < 0.01), the level of TT in observation group was lower than that in control group(P < 0.05), and the differences of the level of PT and APTT between two groups were not statistically significant(P>0.05).The differences of the positive rates of Fg and DD in observation group with different types fracture were not statistically significant(P>0.05), and the difference of the positive rate of FDP in observation group with different types fracture was statistically significant(P < 0.05).Before 1 day of operation, the differences of the levels of Fg, DD and FDP in observation group between patients with and without DVT were not statistically significant(P>0.05).After 7 days of operation, the levels of Fg, DD and FDP in patients with DVT were significantly higher than those in patients without DVT(P < 0.01), and the levels of Fg, DD and FDP in patients with DVT significantly increased compared with before 1 day of operation(P < 0.01). ConclusionsCoagulation index, DD, FDP can effectively reflect the coagulation function of fracture patients, its sensitivity is high, and it has certain guiding value to prevent the DVT formation in patients.
2020, 45(2): 252-255.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.032
Abstract:
ObjectiveTo know the job burnout and factors of occupational instability among full-time personnel of infection management, and explore the relationship between job burnout and the factors of occupational instability. MethodsThe job burnout and occupational instability factors in 52 full-time staff of nosocomial infection management from 29 secondary and tertiary hospitals in Xianyang were investigated using questionnaires according to the stratified random sampling method. ResultsA total of 52 questionnaires were issued, 46 of which were valid, and the effective recovery rate was 88.46%.The incidence rate of the job burnout in full-time staff of nosocomial infection management was 95.65%, which included the mild job burnout for 34.78%, moderate job burnout for 47.83% and severe job burnout for 13.04%.The proportions of the dimensionalities over critical value in emotional exhaustion, depersonalization and accomplishment reducing were 10.87%, 52.17% and 89.13%, respectively.With the dimension of job burnout increasing, the incidence rates of emotional exhaustion and depersonalization exceeding critical value gradually increased(P < 0.01).The top 3 of career instability factors were large work pressure(91.30%), lacking enough attention of leaders(78.26%) and low salary(63.04%).Rank correlation analysis showed that the nosocomial infection interest was negatively correlated with emotional exhaustion(P < 0.05), and the lacking enough attention of leaders was positively correlated with accomplishment reducing(P < 0.05).The multiple linear regression analysis showed that the effect of nosocomial infection management interest on the emotional exhaustion was the most(β=-0.450, P < 0.01), and the effect of lacking enough attention of leaders on accomplishment reducing and job burnout was the most(β=0.273, -0.291, P < 0.10 and P=0.05). ConclusionsThe incidence rate of job burnout among full-time staff in nosocomial infection management in Xianyang is high, and the occurrence of job burnout is related to large work pressure and lacking enough attention of leaders.
2020, 45(2): 255-258.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.033
Abstract:
ObjectiveTo investigate the influencing factors of cognitive impairment in schizophrenic patients complicated with tardive dyskinesia(TD). MethodsThree hundred patients with chronic schizophrenia diagnosed by ICD-10 diagnostic criteria, in Bengbu Mental Health Center from December 2017 to September 2018, were investigated.The Simpson Tardive Dyskinesia Rating Scale was used to screen the cases, and the patients were divided into the TD group(43 cases) and non-TD group(40 cases).The severity of abnormal involuntary movement in TD group was evaluated using AIMS, and the cognitive function in two groups were evaluated using RBANS. ResultsApart from the visual breadth, the scores of the immediate memory, speech function, attention, delayed memory and total score of the RBANS scale in TD group were significantly lower than those in non-TD group(P < 0.01).The results of Spearman correlation analysis showed that the total score of AIMS in TD group was negatively correlated with speech function(P < 0.01), the age was negatively correlated with speech function(P < 0.05), and the degree of education was negatively correlated with immediate memory, visual breadth, delayed memory and total score of the RBANS(P < 0.01).The results of multiple linear regression analysis of demographic data and RBANS factors showed that the age, degree of education, total course of disease, number of hospital stay and other factors had an effect on the cognitive impairment of schizophrenic patients complicated with TD(P < 0.05 to P < 0.01). ConclusionsThe chronic schizophrenic patients complicated with TD have older age, longer course of disease, more severe impairment of cognitive function, and especially the impairment of memory, speech function and attention are affected by age, education level, total course of illness and number of hospital stay.
2020, 45(2): 259-262.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.034
Abstract:
ObjectiveTo investigate the life meaning and death attitude of secondary vocational nursing students and its correlation, and analyze the influencing factors of life meaning for providing reference and basis in carrying out death education courses for nursing students in secondary vocational schools. MethodsA total of 1 516 secondary vocational nursing students were surveyed using the general information questionnaire, Chinese version of life meaning scale and death attitude description scale(revised). ResultsThe total score of the sense of life meaning in secondary vocational nursing students was (40.46±7.27), and the average scores of the seeking life meaning item and life meaning existence item were (4.60±1.03) and (4.41±0.89), respectively.The differences of the scores of life meaning in nursing students with different grades, family location, self-conscious physical and mental health status, and suicidal thoughts were statistically significant(P < 0.01).Among the dimensions of death attitude, the score of natural acceptance dimension was the highest(3.37±0.59), followed by the death escape dimension(3.27±0.64), approach acceptance dimension(3.25±0.53), escape acceptance dimension(3.22±0.64), and fear of death dimension(2.91±0.56).The life meaning existence dimension in life meaning sense was negatively correlated with the death fear, death escape, natural acceptance, approach acceptance and escape acceptance among death attitudes(P < 0.01), while the seeking life meaning dimension was positively correlated with death escape, approach acceptance and escape acceptance among death attitudes(P < 0.05 to P < 0.01). ConclusionsThe sense of life meaning of the secondary vocational nursing students is at medium level, and the natural acceptance is the main death attitude.However, it is still necessary to guide nursing students positively to establish a positive outlook on life and death.
2020, 45(2): 263-266.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.035
Abstract:
ObjectiveTo investigate the situation of hypertension control and its influencing factors in the community of Bengbu, and improve the effective control rate of hypertension. MethodsThe related data of 165 patients with hypertension from the four communities of Dongsheng street and Jiefang street in Longzihu district of Bengbu according to the random sampling were analyzed using χ2 test, t test and logistic regression analysis. ResultsThe control rates of hypertension in 60 cases among 165 patients(36.4%) were up to standard, The single factor analysis results of gender, age, marital status, salt intake etc.showed that there were statistical significances in the effects of age, sleep status, medication status and complications on blood pressure control rate(P < 0.05).According to single factor analysis, the logistic regeression analysis of multiple factors showed that there were statistical significances in the age, irrational drug, sleeping disorders and accompanying diseases(P < 0.05 to P < 0.01).The age ≥65 and antihypertensive drug use were the protective factors of blood pressure control(P < 0.05), and the complications and sleep disorder were the risk factors of blood pressure control(P < 0.01). ConclusionsThe age ≥ 65 and rational drug treatment may be the protective factors of blood pressure control, and the complications and sleep disorder may be the risk factors of blood pressure control.Community should strengthen the standardized management of patients with hypertension to effectively improve the control rate of hypertension.
2020, 45(2): 267-270.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.036
Abstract:
ObjectiveTo revise the Montreal cognitive assessment scale for patients with ischemic stroke use, and evaluate its reliability and validity. MethodsThe scale items were discussed and revised by a group of experts formed by literature review and Delphi method.Three hundred and sixty-nine ischemic stroke patients met with the inclusion criteria were investigated using a questionnaire, and the reliability and validity of the scale were evaluated using the classical measurement theory. ResultsThe retest reliability, Cronbach's α value, Spearman-Brown coefficient and Guttman's half-reliability coefficient of the scale were 0.94, 0.82, 0.87 and 0.85, respectively, the results of which showed that the scale had good reliability.The results of correlation and exploratory factor analysis showed that the scale had good structural validity. ConclusionsStroke version of Montreal cognitive assessment scale has good reliability and validity, which can be used as a tool to evaluate the cognitive function of patients with post-stroke cognitive impairment, yet it needs further improvement.
2020, 45(2): 271-274.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.037
Abstract:
ObjectiveTo study nurses' knowledge state about pregnancy complicated with obstructive sleep apnea syndrome (OSAS) in the department of obstetrics and gynecology. MethodsOne hundred and eight nurses in the department of obstetrics and gynecology were investigated with self-designed questionnaire on knowledge state about pregnancy complicated with OSAS.Univariate analysis and multi-factor linear regression analysis were used to analyze the scores of knowledge about pregnancy complicated with OSAS. ResultsThe overall knowledge score rate of the subjects was 28.57%.Different age, working hour, highest educational background, night shift and OSAS-related knowledge training affected the score of knowledge about pregnancy complicated with OSAS, and the difference was statistically significant(P < 0.05 to P < 0.01).The results of multiple linear regression analysis showed that the score of knowledge about pregnancy complicated with OSAS increased with the increase of working time, and the scores of nurses who received OSAS-related knowledge training and did not have night shift were higher than those who hand night shift and did not receive relevant training(P < 0.05).The definition, etiology, pathogenesis, main symptom and sign, risk assessment scale, harm to mother and infant, and guideline for prevention and treatment were the relevant knowledge that the subjects hoped to learn.Lecture, knowledge handbook and bulletin board were the acceptable ways to acquire knowledge. ConclusionsNurses in the department of obstetrics and gynecology do not have enough knowledge about pregnancy complicated with OSAS, and related training should be actively carried out to provide a basis for the nursing and prevention of pregnancy complicated with OSAS.
2020, 45(2): 275-277, 281.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.038
Abstract:
ObjectiveTo investigate the protective effects of new soft silicone foam dressing Mepilex Lite and Kangfuxin solution on neck skin injury and its effects on emotion in nasopharyngeal carcinoma(NPC) patients treated with radiotherapy. MethodsFifty-four NPC patients treated with radiotherapy were randomly divided into the control group(Mepilex group) and observation group(Kangfuxin group) (27 cases in each group).The control group and observation group were nursed with Kangfuxin solution and Mepilex Lite after 2 d of radiotherapy.The degree of neck skin injury, wound healing time, wound healing proportion, SDS score and SAS score before and after intervention were compared between two groups. ResultsThere was statistical significance in the skin injury between two groups(P < 0.05).The healing time and rate of skin wound in observation group were significantly less and higher than those in control group, respectively(P < 0.01).Before intervention, the differences of the scores of SAS and SDS between two groups were not statistically significant(P>0.05).After intervention, the scores of SAS and SDS in two groups decreased compared with before inervention(P < 0.05), and the scores of SAS and SDS in observation group were lower than those in control group(P < 0.05). ConclusionsThe application of Mepilex Lite can significantly reduce the degree of neck skin injury caused by radiotherapy for nasopharyngeal carcinoma, shorten the healing time of wound surface, and relieve the anxiety and depression of patients, which is worthy of clinical promotion.
2020, 45(2): 278-281.
doi: 10.13898/j.cnki.issn.1000-2200.2020.02.039
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ObjectiveTo translate the nurses self-concept instrument (NSCI) to form the Chinese version of NSCI, and assess the reliability and validity of the scale in nursing undergraduates. MethodsAfter literally and back translating the NSCI, the Chinese version of NSCI was formed through cultural adjustment and revision.A total of 1 284 nursing undergraduates were tested collectively, and the validity of the scale was tested using the professional self-concept of nurse instrument as criterion.Two weeks later, one hundred and twenty-six nursing undergraduates were selected for retest. ResultsThree factors including care, staff relation and leadership were contained in the Chinese version of NSCI, which explained 67.11% of the total variance, and the scale was significantly positively correlated with the criterion scale (r=0.698-0.848, P < 0.01).The confirmatory factor analysis ascertained the three-factor model.The internal consistency of the Chinese version of NSCI was 0.742-0.918, and the retest reliability was 0.736-0.943. ConclusionsThe Chinese version of NSCI has good reliability and validity, and can be used to evaluate the professional self-concept of nursing undergraduates.
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