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2020 Vol. 45, No. 4
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2020, 45(4): 421-424, 428.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.001
Abstract:
Objective To investigate the clinical risk factors of common type evolving into severe type corona virus disease 2019 (COVID-19). Methods The clinical data of 24 patients with common type evolving into severe type COVID-19 were collected(evolution group), the clinical characteristics, blood test results, inflammatory indexes, chest CT imaging characteristics and antiviral treatment were analyzed, which was compared with the clinical data of 41 patients with common type COVID-19 patients(common type group).The possible risk factors of COVID-19 patients developing from common type to severe type were analyzed. Results For the clinical characteristics between evolution group and common type group, the differences of the complication with underlying disease and respiratory rate were statistically significant(P<0.05), and the differences of the sex, age and clinical symptoms were not statistically significant(P>0.05).The results of blood test showed that the lymphocyte counts and plasma albumin level in evolution group were significantly lower than those in common type group(P<0.05), the blood glucose and urea levels in evolution group were significantly higher than those in common type group(P<0.05), and the differences of the white blood cell count, platelet count and alanine aminotransferase levels between two groups were not statistically significant(P>0.05).The inflammatory indexes in evolution group were significantly higher than that in common type group(P<0.05).The double lung ground glass shadow, patchy shadow and consolidation shadow, double lung with diffuse ground glass shadow complicated with bronchogram were the mainly imaging findings of the common type group, and the common type patients with two lung large area consolidation shadow complicated with pulmonary interstitial change were more likely to develop to severe type.The differences of the clinical effects of two and three kinds of drugs treatment between two groups were not statistically significant(P>0.05). Conclusions The combination of underlying diseases, respiratory frequency, lymphocyte count, blood glucose, albumin, urea level, inflammatory factors and imaging manifestations are the possible risk factors of common type evolving into severe type COVID-19.
Clinical characteristics analysis of 24 COVID-19 patients with chronic metabolic underlying diseases
2020, 45(4): 425-428.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.002
Abstract:
Objective To analyze the effects of the chronic metabolic underlying diseases on corona virus disease 2019(COVID-19), and explore the possible measures to predict and ameliorate COVID-19. Methods The basic diseases, clinical manifestations and laboratory examinations in 24 normal and severe COVID-19 patients complicated with chronic metabolic basic diseases were analyzed retrospectively. Results The COVID-19 patients were mostly associated with chronic metabolic basic diseases such as hypertension and diabetes, and most patients in the severe group were associated with a variety of basic diseases with aggravated symptoms, which might be complicated by bacterial infection and myocardial injury.The incidence rate of chest distress and reduction rate of albumin in severe group were higher than those in normal group(P < 0.01 and P < 0.05). Conclusions The COVID-19 is a rapid-developing and variable disease.During treatment, it is important to pay close attention to the development and changes of patients' chronic metabolic basic diseases and prevent the occurrence of bacterial infection and myocardial injury, which is of great significance to promote the patients' recovery.
2020, 45(4): 429-432.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.003
Abstract:
Objective To analyze the clinical characteristics of 74 patients with corona virus disease 2019(COVID-19). Methods The clinical characteristics of 74 pateints with COVID-19 from January 22 to March 4, 2020 from the First Affiliated Hospital of Bengbu Medical College were retrospectively analyzed, and the clinical characteristics were compared between common type and severe type patients. Results Among 74 patients, 35 cases were the common type, and 39 cases were severe/critical type cases.There were high number of familial cluster(37 cases, 50.0%).The age, and rates of complicated with other basic diseases and complicated with two or more basic diseases in severe/critical patients were higher than those in common patients(P < 0.05 to P < 0.01).In terms of clinical symptoms, the time from onset to see doctor in severe/critical patients was longer than that in common patients, and the highest body temperature, incidence rates of chest tightness and dyspnea in severe/critical patients were higher than those in common patients(P < 0.05 to P < 0.01).In terms of laboratory examination, the absolute value of leucocyte and neutrophil, percentage of neutrophil, C-reactive protein and interleukin-6 in severe/critical patients were higher compared with those in common patients, and the absolute value of lymphocyte, percentage of lymphocyte and albumin in severe/critical patients were lower compared with those in common patients(P < 0.05 to P < 0.01).The patchy ground glass opacity in chest CT of all cases were found. Conclusions The number of familial clustering cases of COVID-19 in Bengbu city is more, and the elderly complicated with more basic diseases and systemic inflammatory response are the clinical characteristics of severe/critical patients.
2020, 45(4): 433-436.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.004
Abstract:
Objective To analyze the initial clinical features and imaging finding of corona virus disease 2019 (COVID-19). Methods The clinical data of 46 patients with COVID-19 were retrospectively analyzed.The thin-slice CT scan in all cases were performed to analyze the number of pulmonary segments and lobes, distribution and signs of lesion involvement.According to the time interval between the first symptom and CT examination, the course of disease was divided into the early stage(18 cases, ≤ 3d), middle stage(14 cases, 4-7d) and advanced stage (14 cases, >7d), and the imaging findings were analyzed. Results Among 46 cases with COVID-19, the history of direct or indirect exposure to Wuhan in 45 cases(97.8%) were identified, and the most common clinical symptoms were cough(28/46, 68.6%) and fever (40/46, 87.0%).In terms of clinical symptoms, the lesions were mainly distributed in bilateral lungs(39/46, 84.8%), the diffused distribution was main, and the number of involved lung segments was more than 7(27/46, 58.7%).The thin-section CT images were mainly characterized by pure ground grass opacity (23/46, 50.0%), ground grass opacity complicated with glass grinding consolidation(32/46, 69.6%), paving stone sign(41/46, 89.1%), vascular thickening(41/46, 89.1%), halo sign(34/46, 73.9%) and air bronchogram(38/46, 82.6%).In the early stage of disease, the patients with pure ground grass opacity were more common compared with patients at the middle or late stage of disease.The signs of consolidation in the advanced patients were more common compared with patients at the early and middle stages of disease, and the proportion of the involve lung segment more than 7 in the advanced patients was higher than that in the early and middle stages of disease. Conclusions The clinical and imaging signs of COVID-19 patients are complex and changeable, but which has the certain characteristics, and the CT signs have a certain evolution law.The CT examination combined with clinical symptoms has important clinical significance and value in the early diagnosis of COVID-19.
2020, 45(4): 437-441, 446.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.005
Abstract:
Objective To investigate the expression of necroptosis pathway related protienin diabetic myocardium, and its possible mechanism. Methods The diabetic model of rats was prepared by intraperitoneal injection of 40mg/kg of streptozotocin on the basis of highcalories diet feeding, and divided into the normal group(CON group, n=6), highcalories group(HC group, n=6) and diabetes group(DM group, n=6).After 10 weeks, the left ventricular end diastolic diameter(LVEDD), left ventricular end systolic diameter(LVESD) and left ventricular ejection fraction(LVEF) were detected using ultrasound.The heart weight(HW), body weight(BW), and heart-body ratio(HW/BW) in three groups were measured after the rats were sacrificed.In three groups, the serum levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and maleic dialdehyde(MDA) were detected using ELISA method, the apical tissue were stained using Masson, and the changes of RIPK1, RIPK3 and MLKL in myocardial tissue were detected using RT-PCR and Western blotting. Results Compared with the CON group, the expression levels of HW, TNF-α, IL-6 and MDA increased, and the protein expression levels of RIPK1, RIPK3, and MLKL increased(P < 0.05 to P < 0.01), but the changes of the mRNA expression levels of MLKL were not obvious in HC group(P>0.05).Compared with the HC group, the HW/BW increased, the LVEF decreased, the levels of TNF-α, IL-6 and MDA expression increased, the mRNA and protein levels of RIPK1, RIPK3, and MLKL increased(P < 0.01), and the blue staining of Masson aggravated in DM group. Conclusions High glucose status can induce the myocardial injury, increase the myocardial fibrosis and oxidation level, which may be related to the upregulation of the necroptosis pathway.
2020, 45(4): 442-446.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.006
Abstract:
Objective To investigate the effects of nedaplatin combined with ginsenoside Rg1 on the proliferation of ovarian cancer cells OVCAR-3, and its possible mechanism. Methods The CCK-8 assay was used to detect the effects of ginsenoside Rg1, nedaplatin and their combination on the proliferation of OVCAR-3 cells.Western-blot was used to detect the expression levels of key proteins of Hedgehog pathway(PTCH1, SMO and Gli1).The flow cytometry was used to detect the changes of cell cycle of OVCAR-3 cells after drug intervention. Results Compared with the control group, the proliferation of OVCAR-3 cells in ginsenoside Rg1 group, nedaplatin group and combined drug group were inhibited, and the difference of which among three groups were statistically significant(P < 0.05).At the same time, ginsenoside Rg1 and nedaplatin showed synergistic effects.Compared with the control group, the expression levels of PTCH1, SMO and Gli1 proteins in nedaplatin group, ginsenoside Rg1 group and combined drug group decreased significantly, the difference of which among three groups were statistically significant(P < 0.05), and the synergistic effect between ginsenoside Rg1 and nedaplatin was found.Compared with the control group, only the combined drug group, the cell cycle was arrested at G2 phase(P < 0.05). Conclusions Ginsenoside Rg1 combined with nedaplatin may inhibit the proliferation of OVCAR-3 cells by modulating Hedgehog pathway related proteins to arrest the cell cycle at G2 phase, and ginsenoside Rg1 shows the synergistic effect on nedaplatin.
2020, 45(4): 447-451.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.007
Abstract:
Objective To investigate the effects of hydrogen sulfide (H2S) on spatial learning and memory in diabetic rats, and explore the underlying mechanism. Methods Male rats were randomly divided into normal (CON) group, diabetes mellitus (STZ) group, diabetes+sodium hydrosulfide (NaHS) (SH) group, and normal+NaHS (CH) group, with 8 rats in each group.Type 1 diabetes was induced by a single intraperitoneal injection of streptozotocin.Four weeks after successfully making the model, rats in SH group and CH group were intraperitoneally injected with 56 μmol/kg NaHS solution once a day.After treatment for 4 weeks, the fasting blood glucose (FBG) and body weight (BW) were measured.Spatial learning and memory abilities including escape latency, time spent in the target quadrant, and escape latency to the target quadrant were assessed by Morris water maze.The morphology of hippocampus tissue was observed by HE staining.The levels of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in hippocampus tissue were determined by the kits.The mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in hippocampus tissue were detected using real time-quantitative polymerase chain reaction. Results Compared with the CON group, there was no significant difference in the various indexes in the CH group (P>0.05).In the STZ group, the escape latency and escape latency to the target quadrant were extended, and the time spent in the target quadrant was shortened (P < 0.01).The histological structure of hippocampus tissue was obviously damaged.The levels of FBG and MDA were increased (P < 0.01), whereas BW, the levels of T-AOC, SOD, GSH-Px activity, and Nrf2, HO-1 mRNA expression were decreased, the difference of which was statistically significant (P < 0.01).Compared with the STZ group, except for FBG, the above indicators were markedly improved in the SH group (P < 0.05 to P < 0.01). Conclusions H2S attenuates cognitive dysfunction in diabetic rats, the mechanism of which might be associated with the inhibition of oxidative stress and up-regulation of the Nrf2/HO-1 pathway in hippocampus tissue.
2020, 45(4): 452-455, 460.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.008
Abstract:
Objective To investigate the effects of inhibiting the expression of ubiquitin specific peptidase 22(USP22) on cisplatin resistance in glioma cells. Methods The cisplatin-resistant glioma cell line(U251/CP2) was induced by gradual elevation of cisplatin concentration.The expression of USP22 in glioma cell line U251/CP2 was silenced using the transfection of USP22 small interfering RNA.The expression level of USP22 mRNA, cell apoptosis, viability and drug resistance index and protein level of USP22 were detected using RT-PCR, flow cytometry, CCK-8 and Western blotting, respectively. Results The cisplatin-resistant glioma cell line of U251/CP2 and USP22 gene silencing cell lines of U251-shUPS22 and U251/CP2-shUSP22 were successfully constrcucted.The inhibition of USP22 expression could significantly increase the apoptosis rate of U251/CP2-shUSP22 cells(P < 0.01), and cisplatin could up-regulate the expression of USP22 protein in U251 and U251/CP2 cells(P < 0.01).The IC50 values to cisplatin of U251-shUPS22, U251/CP2, U251/CP2-shUSP22 and U251 cells were (0.56±0.07)μg/mL, (73.73±2.74)μg/mL, (51.25±1.09)μg/mL and (1.23±0.13)μg/mL, respectively. Conclusions The inhibition of USP22 expression can enhance the chemosensitivity to cisplatin in glioma cells, and reverse the resistance of cisplatin in resistant cell line.It is suggested that USP22 may be one of the potential molecular mechanisms of cisplatin resistance in glioma.
2020, 45(4): 456-460.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.009
Abstract:
Objective To investigate the inhibition of atractylenolide Ⅰ on the proliferation of gastric cancer cell line SGC-7901 and its possible mechanism. Methods After the atractylenolide Ⅰ treatment, the inhibitory effects of atractylenolide Ⅰ on the proliferation of gastric cancer cells SGC-7901 were detected using MTT assay, the apoptosis rate and cell cycle of gastric cancer cells SGC-7901 were detected using flow cytometry, and the changes of Cyclin D1 and CDK4 proteins in gastric cancer cells SGC-7901 were detected using Western blotting. Results The results of MTT assay showed that atractylenolide Ⅰ could inhibit the proliferation of gastric cancer cells SGC-7901 in a timeand dose-dependent manner compared with the control group(P < 0.05 to P < 0.01).The results of flow cytometry showed that the atractylenolide Ⅰ could significantly promote the apoptosis of gastric cancer cells SGC-7901(P < 0.01), increase the ratio of G1 phase cells(P < 0.01), and decrease the ratio of G2 phase cells in a dose-dependent manner compared with the control group(P < 0.01).The results of Western blotting showed that atractylenolide Ⅰ could reduce the expression levels of Cyclin D1 and CDK4 proteins in SGC-7901 cells in a dose-dependent manner compared with the control group(P < 0.01). Conclusions Atractylenolide Ⅰ can inhibit the proliferation, and promote apoptosis of gastric cancer cells SGC-7901 by reducing the levels of Cyclin D1 and CDK4 protein to change cell cycle.
2020, 45(4): 461-463, 468.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.010
Abstract:
Objective To compare the efficacy and safety between short tunnel and standard tunnel peroral endoscopic myotomy(POEM) in the treatment of achalasia, and provide the theoretical basis for the individual selection of POEM surgical program. Methods The clinical data of 40 patients with achalasia were retrospectively analyzed.According to the distance of the tunnel opening away gastroesophageal junction(GEJ) position, the patients were divided into the short tunnel group and standard tunnel group.The clinical efficacy, operative time, length of tunnel, length of muscle incision and complications were compared between two groups. Results The total tunnel length, length of muscle incision and operation time in short tunnel group were shorter than those in standard tunnel group(P<0.05 to P<0.01), and the difference of average tunnel length under GEJ between two groups was not statistically significant(P>0.05).The differences of mucosal perforation rate, incidence rate of gas-related complications, fever rate, postoperative following-up time, postoperative Eckardt score, postoperative 3 months increasing of body mass and postoperative GERD incidence rate between two groups were not statistically significant(P>0.05). Conclusions The achalasia patients treated with short tunnel POEM does not increase the incidence rate of postoperative complications, which is safe and effective during the short-term following up.
2020, 45(4): 464-468.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.011
Abstract:
Objective To investigate the effects of dexmedetomidine on the inflammatory response and acute kidney injury in patients treated with coronary artery bypass grafting under cardiopulmonary bypass. Methods Sixty patients scheduled by coronary artery bypass grafting under cardiopulmonary bypass were randomly divided into the dexmedetomidine group(groupD) and control group(groupC) (30 cases in each group).After anesthesia induction, the group D were treated with 1 μg/kg of dexmedetomidine by intravenous pump for 10 minutes, and then 0.4 μg·kg-1·h-1 of dexmedetomidine by intravenous continuous pump until the end of operation.In group C, the same volume of 0.9% sodium chloride solution was pumped intravenously in the same way.The blood samples from internal jugular vein and urine samples were collected before induction of anesthesia(T0), end of cardiopulmonary bypass(T1), end of operation(T2), and after 6 h(T3), 24 h(T4), 48 h(T5), 72 h(T6) of operation.The serum concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP), serum creatinine(SCr), blood urea nitrogen(BUN) and serum cystain C(CysC) were detected.The glomerular filtration rate(GFR) at each time-point were calculated, and the levels of neutrophils gelatinase-associated lipid delivery protein(NGAL), kidney injury molecule-1(KIM-1) and β2-microglobulin(β2-MG) in urine were detected in two groups. Results Compared with T0, the differences of SCr and CysC concentrations between two groups were not statistically significant from T1 to T6 (P>0.05).Compared with T0, the levels of TNF-α, IL-6, CRP, BUN, NGAL, KIM-1 and β2-MG increased, and the eGFR decreased in two groups from T1 to T6(P < 0.05 to P < 0.01).Compared with the group C, the concentrations of TNF-α and IL-6 in group D decreased at T1 to T6, the NGAL and KIM-1 levels decreased at T2 to T6, the CRP and β2-MG levels decreased at T3 to T6, the eGFR values increased at T4 to T6, and the BUN levels decreased at T5 to T6(P < 0.05 to P < 0.01). Conclusions Dexmedetomidine can reduce the degree of inflammatory response caused by coronary artery bypass grafting under cardiopulmonary bypass, and has a protective effect on acute kidney injury.
2020, 45(4): 469-471.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.012
Abstract:
Objective To evaluate the clinical effects of corisolv for minimally invasive caries removal in the treatment of deciduous molar tooth caries. Methods Four hundred children with dental caries aged 4 to 8 years old(400 decayed milk molars) were randomly divided into the control group and observation group(200 cases in each group).The observation group was treated with minimally invasive caries removal, and the control group was treated with traditional turbines technique.The same resin was used for filling in two groups after removal of caries.The patient's compliance, operation time, unexpected pulp exposure and long-term effects(following-up for 6 months and 1 year) were compared between two groups. Results The operation time in observation group was longer than that in control group(P < 0.01).There was statistical significance in incidence rate of pain between two groups(P < 0.01).The unexpected pulp exposure rate in observation group was lower than that in control group(P < 0.01).After 6 months and 1 year of following-up, the success rates of treatment in observation group were higher than that in control group(P < 0.01 and P < 0.05). Conclusions The minimally invasive caries removal in the treatment of deciduous molar tooth caries is safe, painless and effective, which is worthy of clinical promotion.
2020, 45(4): 471-473.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.013
Abstract:
Objective To compare the effects between low-level laser and vacuum sealing drainage(VSD) in the treatment of wound surface. Methods Forty-eight patients with skin soft wound were randomly divided into the laser group(n=24) and VSD group(n=24).The laser group was treated with surgical dressing combined with low-level laser, and the VSD group was treated with VSD.The wound healing, granulation tissue maturity, average hospitalization time, pain degree, therapeutic effect and satisfaction between two groups after 7d and 14d of treatment were compared. Results The differences of the wound healing between two groups after 7 d and 14d of treatment were not statistically significant(P>0.05), and the difference of the granulation tissue maturity between two groups after treatment was not statistically significant(P>0.05).Compared with the VSD group, the average hospitalization time and post-treatment pain in laser group decreased(P < 0.05).The differences of the satisfaction and therapeutic effects bewteen two gorups were statistically significant(P < 0.05). Conclusions The low-level laser in the treatment of wound suurface is simple and can easily be accepted by patients, which can accelerate the healing of the wound, and significantly reduce the pain of patients.It is worthy of clinical promotion.
2020, 45(4): 474-477.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.014
Abstract:
ObjectiveTo explore the effects of visual function training in the treatment of refractive amblyopia in children. MethodsNinety-two children with refractive amblyopia were randomly divided into the routine group(46 cases) and research group(46 cases).Two groups were treated with routine method(atropine combined with covering therapy), and the research group were additionally treated with visual function training.The visual acuity before and after treatment, and normal fusion range, normal separation fusion range, normal stereoscopic composition ratio, effects and safety after treatment were compared between two groups. ResultsBefore treatment, the difference of the visual acuity between two groups was not statistically significant(P>0.05).After 6 months of treatment, the visual acuity in two groups increased significantly, and which in research group was significantly higher than that in routine group(P < 0.01).After 6 months of treatment, the normal fusion range, normal separation fusion range and normal stereoscopic vision rate in research group were significantly higher than those in routine group(P < 0.01).After 6 months of treatment, the total effective rate in research group was significantly higher than that in routine group(P < 0.01), and the difference of incidence rate adverse events between two groups was not statistically significant(P>0.05). ConclusionsThe visual function training in the treatment of refractive amblyopia in children can significantly improve the vision, fusion function and stereopsis, which has good effects, and does not increase the adverse events.
2020, 45(4): 478-481.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.015
Abstract:
ObjectiveTo explore the effects and safety of superior temporal quadrant limbal tunnel microincision phacoemulsification combined with intraocular lens implantation for cataract patients after glaucoma trabeculectomy. MethodsOne hundred and twenty cataract patients treated with glaucoma trabeculectomy were randomly divided into the control group (n=51) and obnservation group (n=51).The observation group and control group were treated with superior temporal quadrant limbal tunnel microincision phacoemulsification combined with intraocular lens implantation and conventional phacoemulsification combined with intraocular lens implantation, respectively.Two groups were followed up for 1 to 6 months after operation, and the degree of corneal astigmatism, best corrected visual acuity, anterior chamber depth, intraocular pressure level and incidence of complications (choroidal detachment, filtering bleb leak, transient increase in intraocular pressure and corneal edema) were analyzed in two groups. ResultsAfter 1 week, the degree of corneal astigmatism in two groups increased compared before operation, and which in observation group was lower than that in control group (P < 0.01).Compared after 1 week of operation, the degree of corneal astigmatism in two groups decreased after 1 month, 3 months and 6 months of operation, and which in observation group after 1 and 3 months was lower than that in control group (P < 0.01).After 1, 3 and 6 months of operation, the best corrected visual acuity, anterior chamber depth and intraocular pressure level in two groups improved, increased and decreased compared before operation, respectively, and the best corrected visual acuity, anterior chamber depth and intraocular pressure level in obseravtion group were higher, greater and lower than whose in control group, respectively (P < 0.05 to P<0.01).The incidence rate of complications in observation group (7.84%) was lower than that in control group (23.53%)(P < 0.05). ConclusionsThe superior temporal quadrant limbal tunnel microincision phacoemulsification combined with intraocular lens implantation for cataract patients after glaucoma trabeculectomy can effectively increase the anterior chamber depth, reduce intraocular pressure and improve the best corrected visual acuity of the patients.The degree of surgically induced astigmatism is mild, and the incidence of postoperative complications is low, which is safe.
2020, 45(4): 482-485.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.016
Abstract:
ObjectiveTo investigate the analgesic effects and side effects of dexmetomidine combined with ropivacaine in continuous femoral nerve block after total knee arthroplasty. MethodsSixty patients with continuous femoral nerve block analgesia after total knee arthroplasty were randomly divided into the control group(group C, 30 cases) and dexmdetomidine group(group D, 30 cases).The analgesic solution in group C and group D were 0.2% ropivacaine and 0.2% ropivacaine combined with 0.1μg·kg-1·h-1.dexmdetomidine, respectively.The scores of resting pain, motor pain and sedation in two groups were recorded before operation and after 3, 6, 12, 24 and 48h of operation.The scores of quadriceps femoris muscle strength were tested before surgery and after 24h and 48 h of surgery, and the bradycardia, hypotension and excessive sedation of adverse reactions were observed in two groups. ResultsThe NRS scores of rest pain and motor pain in group D were significantly lower than those in group C at 6, 12, 24 and 48 hours after surgery(P < 0.05 to P < 0.01).The sedation scores in group D were higher than that in group C at all time-points after surgery(P < 0.01).The incidence rates of hypotension and bradycardia in group D were significantly higher than those in group C(P < 0.05). ConclusionsThe dexmetomidine combined with ropivacaine in continuous femoral nerve block can enhance the analgesic effects and sedation effects, and dose not affect the muscle strength of quadriceps femoris.The hypotension and bradycardia of adverse reactions need to be prevented.
2020, 45(4): 486-488, 492.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.017
Abstract:
ObjectiveTo investigate the clinical effects of levocarnitine combined with erythropoietin in the treatment of hemodialysis with renal anemia. MethodsNinety-eight renal anemia patients with hemodialysis were randomly divided into the control group and observation group according to the digital table method(49 cases in each group).The control group was treated with erythropoietin, and the observation group was treated with levocarnitine combined with erythropoietin.The serum levels of albumin, hemoglobin, serum transferrin, hematocrit and iron metabolism index before and after treatment, and adverse reactions after drug administration were compared between two groups. ResultsBefore treatment, the differences of the serum levels of serum ferritin, transferrin saturation, hematocrit, hemoglobin and serum albumin were not statistically significant between two groups(P>0.05).The serum levels of ferritin, transferrin saturation, hematocrit, hemoglobin and serum albumin in two groups after treatment were higher than before treatment(P < 0.05), and the serum levels in observation group were higher than those in control group(P < 0.01).The elevation of blood pressure, fever and abnormal liver and kidney functions were the main adverse reactions in two groups after treatment, and the total incidence rate of adverse reactions in observation group was lower than that in control group(P < 0.01). ConclusionsThe levocarnitine combined with erythropoietin in treating hemodialysis renal anemia can improve the symptoms of clinical anemia, shorten the course of treatment, promote the recovery of biochemical laboratory indicators, effectively improve the cure rate, reduce complications and improve the quality of life of patients.
2020, 45(4): 489-492.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.018
Abstract:
ObjectiveTo investigate the effects of tiotropium bromide inhalant on clinical symptoms, pulmonary function and quality of life in patients with chronic obstructive pulmonary disease(COPD) in stable group D. MethodsNinety-two patients with stable COPD in group D(according to GOLD 2018) were randomly divided into the observation group(n=46) and control group(n=46).The control group was treated with function exercise and budesonide/formoterol inhalation, and the observation group was treated with tiotropium bromide inhalant on the basis of the control group.After six months of treatment, the lung function(FEV1 and FVC), six-minute walking distance(6MWD), clinical symptom score(CAT), dyspnea degree(mMRC score), quality of life(SGRQ score) were compared between two groups. ResultsAfter treatment, the FEV1 and FVC in two groups were improved compared with those before treatment, and the FEV1 and FVC in observation group were higher than those in control group(P < 0.01).After treatment, the 6MWD in two groups was improved compared with that before treatment, and the 6MWD in observation group was higher than that in control group(P < 0.01).After treatment, the scores of the CAT, mMRC and SGRQ reduced, and the improvement degree in observation group was better than that in control group(P < 0.01). ConclusionsTiotropium bromide inhalant combined with pulmonary function exercise and budesonide/formoterol in treating the stable COPD in group D can effectively improve the symptoms, pulmonary function and quality of life of patients.
2020, 45(4): 493-496.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.019
Abstract:
ObjectiveTo analyze the relationship between BRAFV600E mutation and central lymph node(CLN) metastasis of thyroid papillary carcinoma(PTC), and predict the risk factors of CLN metastasis. MethodsThe BRAFV600E mutation was detected in 104 PTC cases, and the relationships between the mutation and clinicopathological, ultrasonic characteristics of PTC were analyzed.The risk factors of CLN metastasis were analyzed using single factor and multiple factors methods. ResultsBRAFV600E mutation was associated with the maximum diameter of tumor, tumor calcification, extramembrane invasion and CLN metastasis(P < 0.01).The BRAFV600E mutation and extramembrane invasion were the independent factors of CLN metastasis(P < 0.01). ConclusionsBRAFV600E mutation can provide the genetic basis for CLN dissection in PTC surgery.
2020, 45(4): 499-502.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.021
Abstract:
ObjectiveTo observe the changes of the cerebral blooding flow in patients with leukoaraiosis(LA) using transcranial doppler(TCD). MethodsOne hundred and two LA patients diagnosed by MRI and 96 normal elders were divided into the LA group and control group, respectively.The LA group was furtherly divided into group according to different lesion degree by Fazkas scale analysis.All cases were examined using TCD, and the flow velocity(Vm) and pulse index(PI) of the bilateral middle cerebral artery(MCA), anterior cerebral artery(ACA), internal carotid artery(ICA), posterior cerebral artery(PCA), vertebral artery(VA) and basilar artery(BSA) was recorded. ResultsCompared with the control group, the Vm and PI of MCA, ICA, ACA in LA group slowed down and increased, respectively(P < 0.05 to P < 0.01).With the increasing of lesion degree in LA group, the Vm value decreased gradually, and the PI value increased gradually(P < 0.05 to P < 0.01). ConclusionsThe blood in the white matter area of brain is mainly supplied by the internal system of neck, the cerebral flow decreases, and the cerebral vascular resistance increases in LA patients.With the LA degree increasing, the cerebral perfusion decreases.
2020, 45(4): 503-506, 510.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.022
Abstract:
ObjectiveTo explore the application value of the pulse wave velocity in the quantitative detection of carotid elasticity in patients with diabetes mellitus complicated with fatty liver. MethodsSixty patients with type 2 diabetes mellitus(T2DM) combined with nonalcoholic fatty liver disease(NAFLD) were divided into the mild fatty liver group(group A), moderate fatty liver group(group B) and severe fatty liver group(group C) according to the severity of fatty liver(20 cases in each group).The intima-medium thickness(IMT) and pulse wave velocity at the beginning of systole(PWVBS) and pulse wave velocity at the ending of systole(PWVES) at the end of the systole were quantitatively measured using ultrafast pulse wave velocity(UFPWV), and compared with 20 patients with T2DM (T2DM group) during the same period.The results of UFPWV measurement in four groups were compared.The carotid artery elasticity function was compared among four groups.The correlations of IMT, PWVBS and PWVES with fatty liver grading in patients with T2DM combined with NAFLD were analyzed using Spearman correlation coefficient. ResultsThe IMT, PWVBS and PWVES values in patients with T2DM complicated with NAFLD were higher than those in T2DM group, and the differences of which was statistically significant(P < 0.01).The values of IMT, PWVBS and PWVES in group C were significantly higher than those in group A and group B, and which in group B was higher than that in group A(P < 0.01).The results of Spearman correlation analysis showed that the fatty liver index was positively correlated with the IMT, PWVBS and PWVES(r=0.608, 0.668, 0.765, P < 0.01).The results of ROC curve analysis showed that the areas under the curve(AUC) of PWVBS and PWVES in diagnosing carotid arteriosclerosis were 0.868(95% CI：0.809-0.926) and 0.844(95%CI：0.781-0.906), respectively, and the diagnostic efficacy of which was high(AUC >0.5). ConclusionsThe carotid artery elasticity in patients with diabetes mellitus complicated with fatty liver is lower than that in patients with diabetesmellitus.The UFPWV technology can quickly measure and accurately calculate the IMT, PWVBS and PWVES of carotid, the result of which is objective, highly reproducible and easy to operate, which is worthy of clinical evaluation.
2020, 45(4): 507-510.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.023
Abstract:
ObjectiveTo investigate of the application value of smart three-dimensional superb microvascular imaging(SMART 3D-SMI) in the differential diagnosis of thyroid nodules. MethodsThe blood flow distribution and morphological characteristics of nodules were detected using color Doppler flow image(CDFI), two-dimensional superb microvascular imaging(2D-SMI) and SMART 3D-SMI, respectively.The diagnostic efficacy among three methods combined with gray-scale ultrasound in differentiating benign and malignant nodules was compared. ResultsAmong the detection of CDFI, 2D-SMI and SMART 3D-SMI, the differences of the grading of blood flow in benign nodules and malignant nodules were not and were statistically significant, respectively(P>0.05 and P < 0.01).The sensitivities, specificities, accuracy rating, positive predictive values, negative predictive values and areas under curve of CDFI, 2D-SMI, and SMART 3D-SMI combined with gray-scale ultrasound in the diagnosis of benign and malignant thyroid nodules were 71.1% vs 80.0% vs 88.9%, 72.7% vs 80.0% vs 89.1%, 72.0% vs 80.0% vs 89.0%, 68.1% vs 76.5% vs 87.0%, 75.5% vs 83.0% vs 90.7%, and 0.719 vs 0.800 vs 0.890, respectively. ConclusionSMART 3D-SMI can better evaluate the spatial distribution and morphological characteristics of the microvessels of thyroid nodules.The clinical value of SMART 3D-SMI combined with gray-scale ultrasound in the differential diagnosis of thyroid nodules is great.
2020, 45(4): 511-514.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.024
Abstract:
ObjectiveTo evaluate the application value of saline infusion sonohysterograph(SIS) in the diagnosis of common uterine lesions. MethodsThe clinical data of 469 patients detected by transvaginal two-dimen sional (2D) combined with three-dimen sional (3D) ultrasound, SIS and pathological examination were retrospectively analyzed.The results of transvaginal 2D combined with 3D ultrasound and SIS in the diagnosis of uterine cavity lesions were compared with the results of operation.The sensitivity, specificity and coincidence rate between two ultrasonic methods in the diagnosis of uterine cavity lesions were compared. ResultsWith hysteroscopy as the standard, the sensitivity, specificity and coincidence rate of 2D combined with 3D ultrasound in the diagnosis of uterine cavity polyps, submucosal leiomyoma and intrauterine adhension were significantly lower than those of SIS(P < 0.01). ConclusionThe SIS has some advantages over conventional ultrasound in the diagnosis of intrauterine lesions, and can be used as a screening method for clinical infertility patients to find the cause of infertility.
2020, 45(4): 515-518, 522.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.025
Abstract:
ObjectiveTo screen the traditional Chinese medicine with antibacterial activity against pan-drug resistant Klebsiella pneumoniae, and explore its antibacterial mechanism in vitro. MethodsAmong 60 traditional Chinese medicine granules, Chinese medicines with antibacterial activity against 28 pan-resistail strains were screened.The pH value of the antibacterial active liquid was adjusted to neutral, and the antibacterial effects were compared between before and after adjusting pH value.The minimum inhibitory concentration(MIC), minimum bactericidal concentration(MBC), combined bacteriostatic effects and changes of extracellular alkaline phosphatase(ALP) activity of these Chinese medicines with antibacterial activity were detected. ResultsFour kinds of traditional Chinese medicine with antibacterial activity against pan-resistant bacteria were screened out, which included the Scutellariae Radix, Coptis Rhizoma, Ephedrae Herba and Spatholobi Coulis.The MIC of the Scutellariae Radix, Coptis Rhizoma, Ephedrae Herba and Spatholobi Caulis was 64 mg/mL, 64 mg/mL, 128 mg/mL, 128 mg/mL and 256 mg/mL, respectively.The MBC of the Scutellariae Radix, Coptis Rhizoma, Ephedrae Herba and Spatholobi Caulis was 128 mg/mL, 64 mg/mL, 128 mg/mL, 256 mg/mL and 512 mg/mL, respectively.The differences of the antibacterial effects in four kinds of traditional Chinese medicine between before and after adjusting pH value were not statistically significant(P>0.05).The FIC values of the combined application of Scutellariae Radix and Coptis Rhizoma were more than 2.With the increasing of the concentrations of four drugs, the concentrations of ALP increased, and the increasing degree of ALP concentration was more obvious after Scutellariae Radix and Coptis Rhizoma treated. ConclusionScutellariae Radix, Coptis Rhizoma, Ephedrae Herba and Spatholobi Caulis have good antibacterial effect in vitro, the antibacterial mechanism of Scutellariae Radix and Coptis Rhizoma may be related to the increasing of membrane permeability, but the combination of Ephedrae Herba and Spatholobi Caulis has antagonistic effect.
2020, 45(4): 519-522.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.026
Abstract:
ObjectiveTo evaluate the predictive value of the combined detection of neutrophil-to-lymphocyte ratio(NLR) and white blood count(WBC) in severe hand foot mouth disease(HFMD) by ROC curve and logistic regression. MethodsThe clinical data of WBC, blood glucose(GLU), neutrophils, procalcitonin(PCT), NLR and pre-albumin(PA) in 44 cases with severe HFMD and 42 cases with mild HFMD were collected, the ROC curve was drew, and the logistic regression analysis was conducted. ResultsThe differences of the PA, PCT, GLU, NLR and WBC between the severe group and mild group were statistically significant(P < 0.05 to P < 0.01).The ROC curve showed that the optimal threshold of NLR was 2.252, and the WBC predicted that the optimal threshold of severe change was 13.19×109/L.After two continuous variable indixes were reassigned, the results of logistic multifactor regression analysis showed that the NLR and WBC were independent risk factors of severe HFMD.The regression equation of the prediction model was Logit(P)=-2.601+2.933X1+4.530X2, and the goodness of fit test of the model showed that the P value was 0.830, which was more than 0.05.When two indictors were tested together, the sensitivity and specificity of the series predicting severe HFMD were 70.45% and 100.00%, respectively, and the AUC was 0.852.The sensitivity and specificity of the parallel predicting severe HFMD were 93.18% and 88.10%, respectively, and the AUC was 0.906. ConclusionThe combined detection of NLR and WBC has important clinical predictive value for severe HFMD.
2020, 45(4): 523-526.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.027
Abstract:
ObjectiveTo explore the value of the detection of carbohydrate antigen 125(CA125), human epididymis protein 4(HE4) combined with D-dimer in the diagnosis of ovarian malignant tumor. MethodsA total of 122 ovarian malignant tumor patients diagnosed by pathology, 113 benign ovarian tumor patients diagnosed by imaging findings and 121 healthy females at the same tine were divided into the ovarian cancer group, benign ovarian tumor group and control group, respectively.The serum concentrations of HE4, CA125 and D-dimer in three groups were determined, the differences of which among three groups were compared, and the diagnostic significance of the separation and synergy of three indicators was analyzed. ResultsThe serum levels of CA125 and HE4 in ovarian cancer group, benign tumor group and control group gradually decreased in turn(P < 0.05 to P < 0.01).The differences of the serum level of D-dimer level in ovarian cancer group was higher than that in benign tumor group and control group(P < 0.01), and the difference of which between the benign tumor group and control group was not statistically significant(P>0.05).The differences of the serum levels of D-dimer, CA125 and HE4 in ovarian cancer patients with different clinical stages were statistically significant(P < 0.01).With the increasing of ovarian malignant degree, the serum levels of CA125 and HE4 increased.The serum levels of D-dimer in patients with stages Ⅲ and Ⅳ, Ⅱ, and Ⅰ ovarian cancer gradually decreased, the differences of the serum levels of D-dimer among above patients were statistically significant(P < 0.05 to P < 0.01), and the difference of which between the stage Ⅲ and Ⅳ patients was not statistically significant(P>0.05).In the diagnosis of ovarian cancer, the sensitivities of the detection of D-dimer, CA125 and HE4 were 80.33%, 81.97% and 63.93%, respectively.The sensitivity of the combined detection of three indexes was 94.26%.The AUC of the combined detection of three indexes in the diagnosis of the stageⅠtoⅡ and stageⅠto Ⅳ ovarian cancer were 0.913 and 0.959, respectively, which was significantly higher than that of the single indicator detection. ConclusionThe combined detection of serum CA125, D-dimer and HE4 can significantly improve the sensitivity and diagnostic efficiency of ovarian cancer, and the expression levels of three indicators are related to the clinical stage of ovarian cancer.
2020, 45(4): 527-531.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.028
Abstract:
ObjectiveTo investigate the effects of the psychological capital on subjective well-being of nurses in a tertiary hospital. MethodsTwo hundred and forty-two nurses in a tertiary hospital were investigated using the questionnaire of general information, psychological capital scale and subjective well-being scale, and their correlations were analyzed. ResultsThe total scores of the psychological capital and subjective well-being of nurses were(86.62±10.59) and (75.28±10.49), respectively.The differences of the total score of subjective well-being, and satisfaction with life and interest dimension scores of nurses with different marital status were statistically significant(P < 0.05), and the differences of the total score of subjective well-being and energy dimension score of nurses with different ages were statistically significant(P < 0.05 to P < 0.01).The differences of the total score of subjective well-being, satisfaction with life and interest dimension scores, energy dimension score and health worries dimension score of nurses with different titles were statistically significant(P < 0.05).The difference of the energy dimension score in nurses with different working hours was statistically significant(P < 0.05), the differences of the control of emotional and behavioral dimension scores were statistically significant in nurses with different departments(P < 0.05).The results of multiple stepwise regression analysis showed that the optimism and resilience entered the regression equation(P < 0.05 to P < 0.01), and the two variables could explain the 16.5% variation of the total subjective well-being score. ConclusionThe psychological capital and subjective well-being of nurse are optimistic, the psychological capital has significant predicting effect on subjective well-being, and the more optimistic is, the higher the degree of toughness and stronger the subjective well-being are.
2020, 45(4): 532-535, 540.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.029
Abstract:
ObjectiveTo understand the current situation of cyberbullying among higher vocational students in Anhui province, and analyze the correlation between cyberbullying and depression, so as to provide the scientific basis for the intervention of cyberbullying and depression. MethodsThe method of stratified cluster sampling was conducted, a total of 5 049 students from three vocational schools in Anhui province were investigated using questionaire, which included the general demographic characteristics, cyberbullying status and ZUNG self-rating depression scale. ResultsA total of 4 858 valid questionnaires were collected, and the effective rate of questionnaire was 96.22%.Among the subjects, 201 students(4.14%), which included 88 males(43.8%) and 113 females(56.2%), with cyberbullying were identified.The total detection rate of depression was 3.05%(148 cases), which included the 146 cases of mild depression, 2 cases of moderate depression and no major depression.The results of multivariate logistic regression analysis showed that the cyberbullying was a risk factor of depression(P < 0.05), and the risk of developing depressive mood among the victims of cyberbullying was 2.034 times that of noncyberbullying(OR=2.034, 95%CI:1.120-3.696). ConclusionThe cyberbullying is a common phenomenon among vocational college students, which is related to the generation of depression.
2020, 45(4): 536-540.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.030
Abstract:
ObjectiveTo analyze the direct economic burden and its influencing factors of patients with systemic lupus erythematosus(SLE), and provide the reference basis for reducing the economy burden of patients. MethodsThe last year annual direct economic burden in SLE inpatients with disease duration ≥ 1 year in two top three hospitals in Anhui during January to May 2019 was investigated, and a multiple log-linear regression was used to analyze the influencing factors of direct economic burden. ResultsThe median of the annual direct economic burden in 77 SLE inpatients was 15 520.0 Yuan, and the annual direct economic burden of 5.2%(4/77) patients exceeded their annual family income.When the logarithm of the annual direct economic burden was taken as the dependent variable, the results of multiple linear regression showed that the direct economic burden of urban medical insurance and new rural cooperative medical insurance patients were higher than that of self-paid patients(P < 0.01), and the disease activity stage and combined lupus nephritis could increase the annual direct economic burden of patients(P < 0.01).The longer the course of illness was, the lower the annual direct economic burden was(B=-0.09, P < 0.01). ConclusionThe direct economic burden of patients with SLE in Anhui province is heavy.It is necessary to improve the medical insurance compensation mechanism, raise the awareness and proportion of people participating in insurance programs, actively treat complications.
2020, 45(4): 541-543.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.031
Abstract:
ObjectiveTo study the significance of the determination levels of blood lead, cord blood lead and colostrum lead in pregnant women with exposuring in lead area. MethodsForty-five pregnant women living around the electronic waste recycling field were prospectively selected, and set as the observation group.The levels of maternal blood lead, cord blood lead and milk lead in observation group were detected.Forty puerpera living around no high lead exposure area were set as the control group.The levels of maternal blood lead, cord blood lead and milk lead, and neonatal status were compared between two groups. ResultsThe study in 39 cases of the observation group and 38 cases of the control group were completed.The neonatal body mass in observation group was significantly lower than that in control group(P < 0.05), and the difference of the neonatal body length between two groups was not statistically significantly(P>0.05).The levels of maternal blood lead, cord blood lead and colostrum lead in observation group were significantly higher than those in control group(P < 0.01). ConclusionThe women exposuring in high lead environment during pregnancy may lead to fetal lead exposure, and the high foremilk lead may result in the lead exposure during lactation.Therefore we should improve lead prevention work for women living around the lead exposure environment.
2020, 45(4): 544-546, 550.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.032
Abstract:
ObjectiveTo observe the application effects of the self-made protective sheath of arteriovenous fistula(AVF) combined with far-infrared irradiation in maintenance hemodialysis patients treated with ultra-high pressure balloon dilatation. MethodsFifty-two maintenance hemodialysis patients with autologous AVF stenosis treated with ultra-high pressure balloon dilatation were divided into the control group and observation group using random number table method.The control group was routinely nursed with fist clenching, relaxation combined with local hot compress of internal fistula, and the observation group was nursed with the protective sheath of arteriovenous fistula to protect the limbs of the operative side combined with far-infrared radiation at the same time.The natural flow rate of fistula, incidence rate of complications, incidence rate of restenosis of fistula and nursing satisfaction were compared between two groups within 6 months after surgery. ResultsFifty-two patients with fistula could firstly be treated with for hemodialysis after 1-3 days of operation.After 6 months of treatment, the natural flow volume of fistula and nursing satisfaction in observation group were significantly higher than those in control group(P < 0.01), the incidence rate of complications in observation group was significantly lower than that in control group(P < 0.05), and the differences of the incidence rate of restenosis between two groups was not statistically significant(P>0.05). ConclusionThe ultra-high pressure balloon dilatation can effectively relieve the AVF stenosis.The self-made protective sheath of arteriovenous fistula combined with far-infrared radiation can significantly improve the blood flow of arteriovenous fistula, and reduce the incidence rate of complications in maintenance hemodialysis patients.
2020, 45(4): 547-550.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.033
Abstract:
ObjectiveTo observe the effects of nursing intervention cuff pressure combined with nebulized inhalation on improving postoperative throat discomfort in patients with secondary hyperparathyroidism. MethodsNinety patients with secondary hyperparathyroidism were randomly divided into the A, B and C groups(30 cases each group).The group A received general anesthesia, and was admitted to the post-anaesthesia monitoring room (PACU) for routine PACU care immediately after awake extubation.The anesthesia and intubation in group B and group C were the same as the group A, the cuff pressure was dynamically adjusted using external jacket pressure gauge, and maintained at 25~30 cmH2O, group B was admitted to the PACU for routine PAUC care after awake extubation, and the group C was treated with aerosol inhalation of 2 mg budesonide and 5 mL 0.9% sodium chloride solution after awake extubation.The incidence rates and severity of sore throat, dry throat, nausea vomiting and hoarseness in three groups at entering into PACU after extubation(T1), coming out of PACU(T2), postoperative 6 h(T3) and postoperative 24 h(T4) were recorded.The satisfaction of patients was also inquired, and the effects of two nursing methods on the intervention of throat after the general anesthesia were laterally compared. ResultsAt T1, the sore throat score in C group was lower than that in group A and group B (P < 0.01), and the differences of pharyngeal dryness score among three groups were not statistically significant(P < 0.01).At T2, T3 and T4, the scores of sore throat and pharyngeal dryness in group C, group B and group A gradually increased in turn(P < 0.01).The satisfaction in group C was better than that in group B and group A(P < 0.05), and the difference of which between group A and group B was not statistically significant(P>0.05). ConclusionThe nursing intervention cuff pressure combined with atomization inhalation can reduce the postoperative sore throat and pharyngeal dryness, accelerate postoperative recovery of and improve the satisfaction of patients.
2020, 45(4): 551-553.
doi: 10.13898/j.cnki.issn.1000-2200.2020.04.034
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ObjectiveTo explore the clinical effect of nursing intervention based on mechanics principle in patients undergoing hip arthroplasty. MethodsA total of 112 patients undergoing hip arthroplasty were divided into two groups according to the nursing methods.The control group(n=56) was treated with routine nursing, and the observation group(n=56) was treated with routine nursing combined mechanics principle-based nursing.The incidence of stress injury, clinical nursing satisfaction and Harris score of hip joint(including pain, joint function, deformity and mobility) were compared between the two groups. ResultsThe incidence of pressure injury in observation group (3.57%) was lower than that in control group (14.39%)(P < 0.05).The total satisfaction of clinical nursing in observation group was 92.86%, which was significantly higher than that in control group (78.57%)(P < 0.01).Harris total score and the scores of pain, joint function, deformity and mobility in observation group were significantly higher than those in control group (P < 0.01). ConclusionThe effect of nursing intervention based on mechanics principle in patients undergoing hip arthroplasty is obvious.It can reduce the occurrence of pressure injury, improve the satisfaction of nursing, and improve the function of hip joint, which is beneficial to the prognosis and worth promoting.
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