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2020 Vol. 45, No. 7
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2020, 45(7): 841-844.
doi: 10.13898/j.cnki.issn.1000-2020.07.001
Abstract:
ObjectiveTo observe the effect of berberine on the invasion and migration of lung cancer A549 cells induced by transforming growth factor (TGF)-β1. MethodsThe effects of 1.25, 2.5, 5.0 and 10 ng/mL TGF-β1 on the morphology of A549 cells were observed at 24 and 48 h, respectively.Wound scratch assay and Transwell assay were applied to detect the changes of migration and invasion ability of A549 cells treated with different concentrations of TGF-β1 for 48 h.The cytotoxic activity of berberine at the concentration of 0-160 μmol/L in vitro was evaluated by SRB assay to find the safe concentration of berberine, then the effects of berberine at safe concentrations on the migration and invasion induced by TGF-β1 in A549 cells were determined. ResultsA549 cells showed significant epithelial-mesenchymal transition morphological changes and stronger invasion and migration ability after 5 ng/mL TGF-β1 treatment for 48 h.Berberine within the concentration range of 10 μmol/L exhibited no cytotoxicity to A549 cells.Compared with TGF-β1 group, 2.5, 5, 10 μmol/L berberine significantly inhibited the invasion of A549 cells, and 10 μmol/L berberine obviously suppressed the migration of A549 cells. ConclusionBerberine inhibits the invasion and migration of lung cancer A549 cells induced by TGF-β1.
2020, 45(7): 845-849.
doi: 10.13898/j.cnki.issn.1000-2020.07.002
Abstract:
ObjectiveTo investigate the effects of silencing the expression of glycerol-3-phosphate dehydrogenase 2 (GPD2) gene on the biological function (proliferation, apoptosis and invasion) and behavior of lung cancer cells. Methods The RNA interference lentiviral vector containing GPD2 gene (shGPD2) and corresponding control vector (shCtrl) were constructed, and used to infect the H1299 cells.The expression levels of GPD2 gene mRNA and protein in cancer cells were detected using qPCR and Western blotting, respectively.The knockdown efficiency of GPD2 gene was verified.The proliferation, apoptosis and invasion of cells were detected using CCK8 method, flow cytometry and Transwell assay, respectively. ResultsThe lentiviral vector shGPD2 was successfully constructed, and infected H1299 cells.The mRNA and protein levels decreased, and the knockdown efficiency was 73.5% (P < 0.05).After the GPD2 gene expression decreased, the proliferation, apoptosis and invasion ability of H1299 cells significantly slowed down, increased and reduced, respectively (P < 0.01). ConclusionThe GPD2 gene knockdown can effectively inhibit the proliferation of lung cancer cells H1299.
2020, 45(7): 849-853, 858.
doi: 10.13898/j.cnki.issn.1000-2020.07.003
Abstract:
ObjectiveTo construct the recombinant eukaryotic expression vector pZM03 (pBudCE4.1/GLS/IL35/OriM) containing secretory protein of interleukin 35 (IL-35)-bacillus calmette guerin (BCG)recombinant vaccine. MethodsThe chemically synthesized IL-35 gene fragment was cloned into the pBudCE4.1/GLS/OriM, the pBudCE4.1/GLS/IL35/OriM was obtained from the pBudCE4.1/GLS/IL12/OriM, and both of above was used to construct the co-expression vector pZM03 (pBudCE4.1/GLS/IL35/OriM).The recombinant plasmid pZM03 was electrotransformated into the BCG to construct the recombinant co-expression of IL-35 and BCG plasmid pBudCE4.1/GLS/IL35/OriM-BCG. ResultsThe results of the detection of gene, transcription, translation and cellular levels, which included the PCR, sequencing, Western blotting and acid-fast staining methods, showed that the pBudCE4.1/GLS/IL35/OriM-BCG was successfully constructed. ConclusionThe recombinant plasmid pBudCE4.1/GLS/IL35/OriM-BCG can correctly express IL-35, which lays a good foundation for further research on the function and application value of IL-35.
Changes of the serum ALDH2 and NLRP3 activity levels in different degrees of coronary artery disease
2020, 45(7): 854-858.
doi: 10.13898/j.cnki.issn.1000-2020.07.004
Abstract:
ObjectiveTo detect the activity levels of serum mitochondrial acetaldehyde dehydrogenase 2 (ALDH2) and nucleotide-binding oligomerization domain-like receptors protein 3 (NLRP3), analyze the correlations between ALDH2, NLRP3 and different courses of coronary heart disease (CHD), and explore the change rule of both in the occurrence and development of CHD. MethodsA total of 170 chest pain patients detected by coronary angiography were investigated, and 133 CHD patients and 37 normal patients (control group) were identified.One hundred and thirty-three CHD patients were divided into the mild stenosis group (19 cases with stenosis deree of < 50%, is-CHD group), moderate stenosis group (41 cases degree of stenosis with 50% to 75%, ms-CHD group) and severe stenosis group (73 cases with stenosis degree of ≥75%, ss-CHD group) according to the severity of coronary artery stenosis.The activity levels of ALDH2 and NLRP3 in all cases were detected using enzyme-linked immunosorbent assay.The differences of the activity levels of ALDH2 and NLRP3 in CHD patients with different degrees of disease were analyzed, the correlations between activity levels of ALDH2, NLRP3 and occurrence, development of CHD were disscussed.The serological influencing factors of ALDH2 and NLRP3 were analyzed using the Pearson correlation analysis. ResultsThe serum level of creatinine in CHD group was higher than that in control group and ms-CHD group (P < 0.05), the high-density lipoprotein level in ss-CHD group was significantly lower than that in control group (P < 0.01), while the lymphocyte/monocytes in ms-CHD group and ss-CHD group were lower than that in the is-CHD group (P < 0.05).The serum levels of ALDH2 in ms-CHD and ss-CHD groups were lower than that in control group, which gradually decreased with the aggravation of the severity of coronary artery stenosis (P < 0.05-P < 0.01), while the serum level of NLRP3 gradually increased with the aggravation of the degree of coronary artery disease (P < 0.01), and there was a positive correlation between both (P < 0.05).With the increasing of the number of CHD lesions, the level of ALDH2 gradually decreased (P < 0.01), while the level of NLRP3 gradually increased (P < 0.05), and the change of NLRP3 was significant.The serum level of ALDH2 was negatively correlated with Gensini score (r=-0.247, P < 0.01), while the NLRP3 level was positively correlated with Gensini score (r=0.477, P < 0.01).The serum level of ALDH2 was negatively correlated with LDL (r=-0.220, P < 0.05) and the serum level of NLRP3 was negatively correlated with ALDH2 (r=-0.201, P < 0.05). ConclusionWith the aggravation of coronary artery disease, the serum level of ALDH2 gradually decreases, the serum level of NLRP3 gradually increases, and there was a certain correlation between them.
2020, 45(7): 859-863, 867.
doi: 10.13898/j.cnki.issn.1000-2020.07.005
Abstract:
ObjectiveTo explore the effects of aspirin combined with clopidogrel on the blood rheology and intracranial hemodynamics in patients with worsening cerebral infarction (WCI). MethodsNinety-two patients with WCI were divided into the combination group (n=46) and control group (n=46).The control group was treated with the conventional treatment combined with aspirin, and the combination group was treated with conventional treatment combined with aspirin and clopidogrel for two courses. ResultsBefore treatment, the differences of the blood rheology indicators, middle cerebral artery (MCA), anterior cerebral artery (ACA) and posterior cerebral artery (PCA), thromboelastography and National Institutes Health Stroke scale (NIHSS) score between two groups were not statistically significant (P>0.05), but the difference of whole blood viscosity between two groups was statistically significant (P < 0.01).After treatment, the whole blood viscosity, plasma viscosity, hematocrit, fibrinogen, MCA, ACA and PCA significantly decreased in two groups (P < 0.05), the whole blood viscosity, plasma viscosity, hematocrit, MCA, The ACA, PCA, M, Ma, α angle and NIHSS score in combination group were lower than those in control group (P < 0.05).The latency time between the initiation of coagulation and formation of blood clot in combined group was higher than that in control group (P < 0.05), and the results of DSA showed that the arterial stenosis in the combination group had been significantly alleviated.There was no statistical significance in total blood viscosity and fibrinogen between two groups (P>0.05).The adverse reactions in two groups were mild, no intracranial hemorrhage or gastrointestinal bleeding were found (P>0.05). ConclusionClopidogrel combined with aspirin in the treatment of WCI is helpful to improve the blood flow, reduce the risk of thrombosis, further prevent the stenosis of intracranial artery congestion, and improve the neural function of patients.
2020, 45(7): 864-867.
doi: 10.13898/j.cnki.issn.1000-2020.07.006
Abstract:
ObjectiveTo study the relationship between the serum levels of matrix metalloproteinase (MMP), thrombospondin (TSP) and cerebral edema and hematoma in acute phase of cerebral hemorrhage. MethodsSixty-two patients with acute hypertensive cerebral hemorrhage and 50 normal people were divided into the observation group and control group, respectively.The serum in observation group on the 1st, 2nd, 3rd, 5th and 7th day and seventh day of onset and control group at physical examination were collected.The levels of MMP 2, MMP9, TSP1 and TSP2 in two groups were detected using enzyme-linked immunosorbent assay (ELISA).The CT scan of brain in two groups was simultaneously performed to measure the volume of cerebral hematoma and edema.The correlations of the serum levels of MMP 2, MMP9, TSP1 and TSP2 with volume of cerebral hematoma and cerebral edema were analyzed. ResultsThe serum levels of MMP 2, MMP9 and TSP1 in observation group at different time-points were significantly higher than those in control group (P < 0.01).The levels of MMP2, MMP9 and TSP1 in observation group on the 3rd, 5th and 7th days were significantly higher than that on the 1st day (P < 0.01), reached a peak on the 3rd day (P < 0.01), gradually decreased on the 5th and 7th day (P < 0.01), and the level of TSP2 increased significantly with the duration of onset (P < 0.01).The brain edema volume in observation group on the 3rd, 5th and 7th days were significantly higher than that on the first day (P < 0.01), reached a peak on the 3rd day (P < 0.01), and gradually decreased on the 5th and 7th days (P < 0.01).On the 1st day of onset, the brain hematoma volume reached a peak (P < 0.01), and then gradually decreased (P < 0.01).The results of correlation analysis showed that the serum levels of TSP1, MMP2 and MMP9 were significantly positively correlated with brain edema volume (P < 0.01), and negatively correlated with the cerebral hematoma volume (P < 0.01).The serum level of TSP2 was significantly negatively correlated with brain edema volume (P < 0.01), and positively correlated with the cerebral hematoma volume (P < 0.01). ConclusionThe serum levels of MMP and TSP in acute phase of cerebral hemorrhage are related to the cerebral edema volume, and the TSP can affect the degree of cerebral hematoma and edema by regulating the expression level of MMP.
2020, 45(7): 868-871.
doi: 10.13898/j.cnki.issn.1000-2020.07.007
Abstract:
ObjectiveTo compare the expression changes of lymphocyte subsets in acute myocardial infarction (AMI) patients treated with between emergency percutaneous coronary intervention (PCI) and drug, and explore the immune defence mechanism of AMI occurrence. MethodsSixty AMI patients were set as the observation group[including 30 cases treatment with PCI combined with medication (PCI group) and 30 cases treatment with conventional medication (medication group), and 30 healthy people treated without special treatment were set as the control group.The peripheral blood of two groups were collected on the day of admission, the peripheral blood in the observation group were collected after 30 days of following-up.The expression of lymphocyte subsets was determined by flow cytometry, and the content of troponin Ⅰ (cTnI) in peripheral blood of the observation group was also detected. ResultsCompared with the control group, the percentages of CD3+CD8+ and CD19+ B lymphocytes increased, the percentages of CD3+CD4+ and CD4+/CD8+ ratio decreased in the observation group, and the differences of whose were statistically significant (P < 0.05 to P < 0.01).After 30 days of treatment, the expression of lymphocyte subsets in the PCI group was contrary to that in the drug group, and the difference of which was statistically significant (P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the CD4+/CD8+ ratio was negatively correlated with cTnI (r=-0.53, P < 0.05). ConclusionsLymphocyte subsets are involved in the inflammatory response of AMI.The PCI therapy can repair myocardial immune inflammatory injury in AMI patients to different degrees.The CD4+/CD8+ ratio is negatively correlated with cTnI.The lower the CD4+/CD8+ ratio is, the higher the cTnI is, and which suggests that the more severe the myocardial damage is, the worse the prognosis is.
2020, 45(7): 871-875.
doi: 10.13898/j.cnki.issn.1000-2020.07.008
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ObjectiveTo observe the clinical efficacy and side effects of tegafur/gimeracil/oteracil concurrent chemotherapy combined with radiotherapy in the treatment of esophageal cancer in elderly patient. MethodsThe clinical data of elderly patients with esophageal cancer were retrospectively analyzed, which included 35 patients treated with radiotherapy alone and 35 cases treated with concurrent chemotherapy.The two groups were treated with three-dimensional conformal intensity modulated radiotherapy.The concurrent chemotherapy group was additionally treated with single agent chemotherapy with tegafur/gimeracil/oteracil.The short-term efficacy was evaluated according to the criteria for evaluating solid tumors (complete remission, partial remission, disease stability and disease progression), and the side effects were evaluated using NCI-CTC.The two groups were followed up for 2 years, the median overall survival time and overall survival rate were compared between two groups. ResultsThe total effective rate in concurrent chemotherapy group (85.71%) was higher than that in chemotherapy alone group (60.0%) (P < 0.05).Two groups did not appear because of the adverse reactions to death or termination of the treatment of patients, patients could tolerate, and the differences of the incidence rates of grade Ⅲ ~ Ⅳ bone marrow suppression and radiation esophagitis between two groups were not statistically significant (P>0.05).During two years of following up, one case in concurrent chemotherapy and 3 cases in chemotherapy alone group losed to follow up.The time of median survival time and 2-year survival rate in concurrent chemotherapy group (24 months and 73.53%) were higher than those in chemotherapy alone group (18 months and 46.88%), respectively (P < 0.05). ConclusionsThe tegafur/gimeracil/oteracil concurrent chemotherapy combined with radiotherapy in the treatment of esophageal cancer in elderly patient has good short-term effects and less side effects, which can significantly improve the overall survival rate of elderly patients.
2020, 45(7): 876-879.
doi: 10.13898/j.cnki.issn.1000-2020.07.009
Abstract:
ObjectiveTo investigate the expression levels and clinical significance of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and progesterone receptor membrane component 1 (PGRMC1) in fetal membrane tissues of pregnant woman with premature rupture of membranes (PROM). MethodsSixty pregnant women treated with cesarean section because of full-term PROM to stop the pregnancy in obstetrics department were set as the PROM group.After delivery, the chorioamnionitis (CAM) in PROM group were identified using placenta pathological examination.Sixty healthy pregnant women treated with cesarean delivery in the same period were set as the control group.The expression levels of TRAIL and PGRMC1 protein in fetal membrane tissues were detected using the immunohistochemistry and Western blotting, and analyzed using statistical method. ResultsThe TRAIL and PGRMC1 were mainly expressed in chorion and decidua layers of membranes.Compared with the control group, the positive expression rates of TRAIL and PGRMC1 in fetal membrane tissues in PROM group significantly increased and decreased, respectively (P < 0.01).The relative expression levels of TRAIL and PGRMC1 protein in fetal membrane tissues in PROM group significantly increased and decreased compared with the control group, respectively (P < 0.01).The differences of the positive expression rates of the TRAIL、PGRMC1 in fetal membrane tissues of PROM pregnant women with or without CAM were not statistically significnat (P>0.05).The relative expression level of TRAIL protein in patients with CAM was significantly higher than that in patients without CAM (P < 0.01), while the relative expression level of PGRMC1 in patients with CAM was significantly lower than that in patients without CAM (P < 0.01). ConclusionsThe expression levels of TRAIL and PGRMC1 proteins in fetal membrane tissues of PROM pregnant women are high and low, both play an important role in the pathogenesis of PROM, and are related to CAM, which can be used as a reference index for clinical examination and diagnosis.
2020, 45(7): 880-882, 887.
doi: 10.13898/j.cnki.issn.1000-2020.07.010
Abstract:
ObjectiveTo explore the application value of the internal iliac artery balloon occlusion in cesarean section patients with pernicious placenta previa (PPP). MethodsThe clinical data of 86 puerperas were retrospectively analyzed.Fifty cases treated with internal iliac artery balloon occlusion and 36 cases treated with cesarean section were divided into the balloon group and control group, respectively.The operative time, intraoperative blood loss, intraoperative blood transfusion, hysterectomy rate, postoperative hospital stay and related complications were compared between two groups. ResultsThe intraoperative blood loss and intraoperative red blood cell transfusion in balloon group[ (1 585.3±769.9)mL, (4.5±3.8)U] were less than those in control group[ (2 044.1±1 362.9)mL, (6.8±4.9)U], respectively (P < 0.05).The hysterectomy rate and bladder injury rate in balloon group and control group were (40.00%, 12.00%) and (44.44%, 11.11%), respectively, and the difference of which was not statistically significant (P>0.05).One case of right lower extremity artery thrombosis occurred in balloon group. ConclusionsThe internal iliac artery balloon occlusion in cesarean section patients with PPP can reduce the amount of intraoperative blood loss and blood transfusion, but not effectively reduce the rate of uterine resection, and has a risk of occuring thrombus.
2020, 45(7): 883-887.
doi: 10.13898/j.cnki.issn.1000-2020.07.011
Abstract:
ObjectiveTo analyze the coagulation function index and platelet parameters of patients, and explore their clinical significance in preeclampsia (PE). MethodsSeventy-eight pregnant women with PE were set as the observation group, and subdivided into the observation group 1 (early PE group, 20 weeks ≤gestational weeks < 34 weeks) and observation group 2 (late PE group, onset ≥34 weeks).At the same time, 80 healthy pregnant women were set as the control group, and subdivided into the control group 1 (20 weeks ≤gestational weeks < 34 weeks) and control group 2 (onset ≥34 weeks).The blood of all cases was collected, and the blood pressure was measured.The indicators of coagulation function and platelet parameters were detected.The correlation between D-dimer (D-D) and coagulation function indexes were analyzed using the Pearson test. ResultsThe body mass index (BMI), D-D, systolic pressure (SBP), diastolic pressure (DBP), mean platelet volume (MPV) and platelet distribution width (PDW) in observation group 1 were higher than those in control group 1 (P < 0.01).The BMI, SBP and DBP in observation group 2 were higher than those in control group 2 (P < 0.01).The D-D in observation 1 group was higher than that in observation group 2 (P < 0.01).The levels of BMI, D-D, DBP and MPV in control group 2 were higher than those in control group 1 (P < 0.05 to P < 0.01).The levels of BMI, D-D, SBP, DBP and MPV in observation group were higher than those in control group (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group 1 and control group 1 were statistically significant (P < 0.05 to P < 0.01).The differences of the levels of PT, INR, FIB and TT between the observation group 2 and control group 2 were statistically significant (P < 0.01).The difference of the level of TT between the observation group 1 and observation group 2 was statistically significant (P < 0.05).The differences of the levels of FIB and TT between the control group 1 and control group 2 were statistically significant (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group and control group were statistically significant (P < 0.01).The D-D in PE patients was negatively correlated with the levels of gestational weeks, PT, INR, APTT, and TT (r=-0.289, -0.235, -0.247, -0.236, -0.351, -0.286, P < 0.05 to P < 0.01), and the D-D was not correlated with the levels of FIB, MPV, and PDW in PE patients (P>0.05). ConclusionsThe high coagulation status in early PE patients is more obvious than that in late PE patients.The D-D in PE patients is closely related to coagulation function, and the D-D can be used as a biological marker to predict the incidence of PE.
2020, 45(7): 888-891.
doi: 10.13898/j.cnki.issn.1000-2020.07.012
Abstract:
ObjectiveTo explore the effects of different doses of low-molecular-weight heparin (LMWH) on the pulmonary infection, digestive system bleeding and incidence of cardiovascular and cerebrovascular events, analyze the correlation between the dose of heparin and clinical indicators, and provide theoretical basis for guiding the individualized use of LMWH in maintenance hemodialysis patients. MethodsThe correlation between the dose of heparin and clinical indicators in 108 patients treated with maintenance hemodialysis was analyzed using the single-center cross-section study.The patients were divided into the low-dose group (treatment with the dosage of LMWH < 40 IU/kg) and high-dose group (treatment with the dosage of LMWH ≥40 IU/kg).The differences of the pulmonary infection, bleeding of digestive system, incidence of cardiovascular and cerebrovascular events, and clinical indicators were compared between two groups. ResultsThe results of Pearson correlation analysis showed that the LMWH dosage per unit body mass was positively correlated with hemoglobin level (r=0.213, P < 0.05), and the LMWH dosage was negatily correlatied with erythropoietin in patients treated with maintenance hemodialysis (r=-0.225, P < 0.05).There was no statistical significance in the incidence rates of pulmonary infection, digestive system bleeding, and cardiovascular and cerebrovascular events between two groups (P>0.05).The levels of ferritin and transferrin saturation in low-dose group were greater than those in high-dose group (P < .01), and the differences of other clinical indicators between two groups were not statistically significant (P>0.05). ConclusionsThe dose of LMWH has no significantly impact on the risks of pulmonary infection, digestive system bleeding and cardiovascular and cerebrovascular events.The greater the hemoglobin usage is, the higher the hemoglobin levels and the lower the erythrotropin dose are.
2020, 45(7): 891-894.
doi: 10.13898/j.cnki.issn.1000-2020.07.013
Abstract:
Objective To investigate the efficacy and adverse reactions of two different doses of glucocorticoid in the treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP). Methods The clinical data of 97 RMPP children treated with systemic glucocorticoid were retrospectively analyzed.The children were divided into the low-dose group (treatment with methylprednisolone ≤1 mg·kg-1·d-1, or its equivalent) and conventional dose group (treatment with methylprednisolone 1-2 mg·kg-1·d-1, or its equivalent).The clinical course, laboratory parameters, treatment effects and adverse reactions between two groups were compared. Results The antipyretic time and hospitalization time in conventional dose group were significantly less than those in low-dose group (P < 0.01).After treatment, the levels of CRP, PCT and LDH in conventional dose group were lower than those in low-dose group (P < 0.05).There was no statistical significance in the curative effects between two groups (P>0.05).The incidence rate of adverse reactions in low-dose group were lower than those in conventional dose group (P < 0.05). Conclusion Although the conventional dose of glucocorticoid can shorten the antipyretic time and hospitalization of children with RMPP, there is no difference in the efficacy between two doses, and the incidence rate of adverse reactions in the low-dose group is lower.
2020, 45(7): 895-897, 901.
doi: 10.13898/j.cnki.issn.1000-2020.07.014
Abstract:
Objective To compare the clinical effects between percutaneous nephrolithotomy (PCNL) and flexible ureteroscopy lithotripsy (FURL) in the treatment of kidney stone with a diameter of 2 to 3 cm. Methods The clinical data of 50 patients with kidney stone were retrospectively analyzed.Twenty-five cases treated with PCNL and 25 cases treated with FURL were divided into the PCNL group and FURL group, respectively.The stone-free rate, operating time, blood transfusion rate, hemoglobin drop and postoperative hospitalization time were compared between two groups. Results The stone clearance rates in the FURL group and PCNL group were 72.00% and 80.00%, respectively, and the difference of which was not statistically significant (P>0.05).The operation time in PCNL group was shorter than that in FURL group (P < 0.01), and the hemoglobin drop and postoperative hospitalization time in PCNL group were greater than those in FURL group (P < 0.01).There was no statistical significances in the blood transfusion rate, postoperative urinary tract infection rate, and secondary surgery or ESWL rate between two groups (P>0.05). Conclusion Both FURL and PCNL are effective methods for treating kidney stones with a diameter of 2 to 3 cm, but FURL has less blood loss and shorter recovery time compared with PCNL.
2020, 45(7): 898-901.
doi: 10.13898/j.cnki.issn.1000-2020.07.015
Abstract:
Objective To compare the difference of anatomical structure between seizer eyes and nonseizer eyes of patients with acute angle closure glaucoma (AACG) complicated with cataract, and explore the time of simple cataract extraction in AACG patients complicated with cataract. Methods The clinical data of 30 cases (60 eyes) with AACG complicated with cataract were collected, which included one eye with acute seizer (1 or more times), contralateral eye with nonseizer, and correction vision of both eyes ≤0.3.The axis, lens thickness, angle opening distance 500 (AOD500) and anterior chamber depth (ACD) between two groups before treatment were compared.The visual acuity improvement and incidence rate of complications after treatment were compared between two groups. Results Before treatment, there was no statistical significances in eye axis, crystal thickness and crystal thickness/eye axis between two groups (P>0.05), and the AOD500 and ACD in seizer group were greater than those in nonseizer group (P < 0.01).After treatment, the ACD in nonseizer group and seizer group was deeper than that before treatment (P < 0.01 and P < 0.05), the IOP in seizer group was lower than that before treatment (P < 0.01), and the IOP in nonseizer group was normal after treatment (P>0.05).After 5 patients without reaching the resting state in seizer group were removed, the difference of ACD between two groups was not statistically significant (P>0.05), and the AOD500 in nonseizer group was greater than that in seizer group (P < 0.05).In terms of postoperative complications, one case with posterior cataract in nonseizer group, and 1 case with posterior cataract, 2 cases with residual glaucoma and 4 cases with cataract aggravation in seizer group were found.The incidence rate of which in nonseizure group[3.33% (1/30)] was lower than that in seizer group[23.3% (7/30)] (P < 0.05). Conclusion The peripheral angle parameter AOD500 of patients with AACG complicated with cataract in resting state of the seizer eye is significantly less than that in nonseizer eye.The cataract extraction in pre-clinical patients with AACG complicated with cataract during nonseizer can effectively reduce the incidence rate of AACG, and improve the long-term vision.
2020, 45(7): 902-905, 909.
doi: 10.13898/j.cnki.issn.1000-2020.07.016
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Objective To analyze the effects of nanometer silver dressing combined with epidermal growth factor gel on the wound treatment of deep Ⅱ degree burn. Methods One hundred and fifty-six patients with deep Ⅱ degree burn were randomly divided into the observation group and control group by digital table method (78 cases in each group).After the debridement, the observation group was treated with nanometer silver dressing combined with epidermal growth factor gel, and the control group was treated with epidermal growth factor gel.The wound surface condition was observed at changing the dressing.The visual analogue scale (VAS) of wound before and after 1 week of treatment, scab solubility of wound surface after 1, 2, 3 and 4 weeks of treatment, positive rate of bacterial culture, time of completing dissolution and healing time of wound were compared between two groups.The expression levels of matrix metalloproteinase-1 and 2 (MMP-1 and MMP-2) in two groups before and after 2 weeks of treatment were detected using immunohistochemistry.The incidence rates of adverse reactions before and after treatment were recorded. Results In the observation group, the wound scab skin became soft on the 4th day, most of the scab shell fell off on the 6th day, and the wound scab skin basically dissolved on the 8th day.In the control group, the dry scab wound formed on the 4th day, the wound became dry on the 6th day, some necrotic tissues were yellowish black, but not yet shed, the dry scab gradually softened on the 8th day, and the dry scab gradually fell off and basal granulation tissue grew on the 10th day.After treatment, the VAS scores in two groups were significantly lower than that before treatment (P < 0.01), and which in observation group was significantly lower than that in control group (P < 0.01).The wound dissolving rates in observation group at 1 and 2 weeks after treatment were significantly higher than that in control group (P < 0.01).The dissolution time and wound healing time in observation group were significantly shorter than those in control group (P < 0.01).The positive rate of bacteria in observation group (11.54%) was significantly lower than that in control group (24.36%) (P < 0.05).Compared with before treatment, the expression levels of MMP-1 and MMP-2 in two groups significantly decreased, and which in observation group were significantly lower than those in control group (P < 0.01). Conclusion The nanometer silver dressing combined with epidermal growth factor gel in the treatment of the wound of deep Ⅱ degree burn has high dissolving rate of scab and short wound healing time, the mechanism of which may be related to the expression inhibition of MMP-1 and MMP-2 in wounds.
2020, 45(7): 906-909.
doi: 10.13898/j.cnki.issn.1000-2020.07.017
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Objective To investigate the effects of thyroid mesangectomy on lymph node dissection in central region of thyroid papillary carcinoma patients, and its influence on long-term prognosis. Methods One hundred and forty thyroid papillary carcinoma patients treated with radical thyroidectomy were divided into the observation group (50 cases treatment with thyroid mesangectomy) and control group (90 cases treatment with conventional central lymph node dissection).The surgical indexes, postoperative complications, and serum levels of postoperative parathyroid hormone (PTH) and calcium were compared between two groups.The patients were followed up to January 2019, and the recurrence and metastasis rate was compared between two groups. Results The operation time in observation group was significantly longer than that in control group (P < 0.01).There was no statistical significance in the amount of intraoperative blood loss, postoperative hospital stay and postoperative ambulation time between two groups (P>0.05).There was no statistical significance in the serum levels of PTH and calcium between two groups before and after operation, and the difference of postoperative complications was not statistically significant (P>0.05).No patients in the observation group received secondary surgery, while 1 patient in the control group received secondary surgery, and the difference of which was not statistically significant (P>0.05).During the following up of 24 to 60 months, the recurrence and metastasis rate in observation group was lower than that in control group (P < 0.05).The results of multivariate analysis showed that the TNM staging, extraglandular invasion, lymph node metastasis and thyroid mesangial resection were the independent factors influencing the recurrence and metastasis rate of thyroid papillary carcinomas (P < 0.05). Conclusion The short-term efficacy of thyroid mesangectomy is comparable to that of conventional central lymph node dissection.The long-term recurrence and metastasis rate is lower, and the long-term prognosis is better.
2020, 45(7): 910-912.
doi: 10.13898/j.cnki.issn.1000-2020.07.018
Abstract:
Objective To study the clinic intensity of high energy laser combined with pain point block in the treatment of periarthritis of shoulder. Methods A total of 100 patients with periarthritis of shoulder were randomly divided into the observation group and control group using the digital table method.The control group was treated with pain point block, and the observation group was additionally treated with high intensity laser based on the control group for 4 weeks.The pain visual analogue (VAS) score, Constant-Murley shoulder joint score (CMS), and shoulder joint mobility between two groups were compared before and after treatment, and the comprehensive treatment effects were evaluated. Results The CMS and VAS scores in two groups were significantly improved after treatment, and which in observation group were significantly higher than those in control group (P < 0.01).The shoulder joint mobility in two groups was significantly improved after treatment (P < 0.01).After treatment, the internal rotation, external rotation, forward flexion and abduction of shoulder joint in observation group were higher than those in control group (P < 0.01), and the clinical efficacy of the observation group was better than that of the control group (P < 0.05). Conclusion The high intensity laser therapy based on the pain point block can significantly improve the shoulder joint function, pain symptoms and joint range of motion in patients with periarthritis of shoulder.
2020, 45(7): 913-916.
doi: 10.13898/j.cnki.issn.1000-2020.07.019
Abstract:
Objective o observe the changes of postoperative delirium-related scales and cytokines in elderly patients with stroke after intravenous dripping Xingnaojing injection at the end of lumbar spinal surgery. Methods Forty patients with stroke were treated with lumbar spine surgery under general intravenous anesthesia, and divided into the Xingnaojing group and control group using random table method (20 cases in each group).The induction and maintenance of general anesthesia were controlled by propofol effect room and remifentanil effect room, and the EEG dual spectrum index (BIS) was used to guide the maintenance of anesthesia depth between 40-60.When the infusion of propofol and remifentanil stopped at the end of operation, the Xingnaojing group was intravenously infused with 10 mL Xingnaojing injection and 10 mL of 0.9% sodium chloride solution, the control group was intravenously infused with 20 mL 0.9% sodium chloride solution, and the patients were self-resuscitation.Before the patient entering the room (T0), after 1 day of operation (T1), and after 3 days of operation (T2), two groups were investigated using the mini-mentalstate examination (MMSE) and confusion assessment method (CAM) scale.The serum levels of interleukin 6 (IL-6) and S-100β in two groups were measured at T0 and T1. Results The total score of MMSE in Xingnaojing group was higher than that in control group at T1 and T2 (P < 0.05-P < 0.01), and the differences of which in Xingnaojing group among different time-points were not statistically significant (P>0.05).In control group, the differences of the total score of MMSE among different time-points were statistically significant (P < 0.05), and which at T1 and T2 were lower than that at T0 (P < 0.05).The directional force in Xingnaojing group at T2 was significantly lower than that at T0 (P < 0.05), and which in control group at T1 and T2 were lower than that at T0 (P < 0.05 to P < 0.01).The recall abilities in Xingnaojing group at T1 and T2 were higher than that in control group (P < 0.05 to P < 0.01).The CAM score in Xingnaojing group at T2 was significantly lower than that in control group (P < 0.05), the CAM score in Xingnaojing group at T2 was significantly higher than that at T0 and T1 (P < 0.01), and the CAM score in control group at T2 was significantly higher than that at T0 and T1 (P < 0.01).The IL-6 level in Xingnaojing group at T1 was lower than that in control group (P < 0.05), the difference of the IL-6 level in Xingnaojing group between T2 and T0 was not statistically significant (P>0.05), and the IL-6 level in control group at T1 increased compared with at T0 (P < 0.05).The differences of the levels of S-100β between two groups at T0 and T1, and between T0 and T1 in two groups were not statistically significant (P>0.05). Conclusion The application of Xingnaojing injection at the end of surgery can inhibit the downward trend of MMSE score, prevent the upward trend of CAM scale, and reduce the secretion of IL-6 in elderly patients with stroke to some extent.
2020, 45(7): 917-920.
doi: 10.13898/j.cnki.issn.1000-2020.07.020
Abstract:
Objective To evaluate the efficacy and safety of apatinib combined with tegafur in the treatment of liver cancer after the failure of initial treatment. Methods A total of 87 patients with advanced hepatocellular carcinoma after the failure of initial treatment were selected, 46 cases were treated with apatinib combined with tegafur (observation group), and 41 cases were treated with tegafur alone (control group).The clinical efficacy, survival, quality of life and adverse reactions were compared between two groups. Results The objective response rate and disease control rate in observation group were significantly higher than those in control group (P < 0.05).The median survival time in observation group were significantly higher than that in control group (P < 0.05).The improvement rate of life quality in observation group significantly increased compared with that in control group (P < 0.05).The proteinuria, transient transaminase lifts, white blood cells reducing, high blood pressure, diarrhea and esophagitis were the common adverse reactions of apatinib combined with tegafur, and the difference of Ⅲ degrees or more adverse reaction rate between two groups was not statistically significant (P>0.05). Conclusion The apatinib combined with tegafur in the treatment of liver cancer after the failure of initial treatment can improve the short-term efficacy, prolong the survival time and improve the quality of life, the adverse effects is tolerable, and it is worthy of further research and application.
2020, 45(7): 927-930.
doi: 10.13898/j.cnki.issn.1000-2020.07.023
Abstract:
Objective To discuss the knowledge, attitude, behavior and knowledge demand of vaccination for left-behind and non-left-behind child guardians and targeted intervention mode. Methods Sixty-four physical examination rural left-behind children (group A) and 64 non-left-behind children (group B) from December 2016 to December 2018 were selected.The present situation of child vaccination rate were investigated using the children vaccination card, and the knowledge, attitude and behavior of vaccination and knowledge demand and targeted intervention mode of children's guardians were understood using the way of questionnaire. Results Among 128 children, 93 (72.65%) children were vaccinated with basic vaccines throughout the course, which included 34 left-behind children (36.56%) and 59 non-left-behind children (63.44%).The vaccination rates of 3 times vaccination rates of hepatitis B vaccine and polio vaccine, JE vaccine, DPT (Diphtheria, Pertussis, Tetanus) vaccine, and group A epidemic cerebrospinal meningitis vaccine in non-left-behind children were higher than those in left-behind children (P < 0.05 to P < 0.01).All child guardians for the vaccination knowledge of the questionnaire designing had a good understanding, and the correct recognition rates of "know which two vaccine are needed for birth", "know the effect of vaccination", and "know when children start to vaccination" in guardians of group B children were higher than those in guardians of group A children (P < 0.05).There was no statistical significance in the correct recognition rate of other 7 items of vaccination knowledge between the guardians of two groups (P>0.05).Among the 5 vaccination behaviors and needs, the proportion of "believe that the vaccination place is too far away" in guardians of children in group A was higher than that of guardians of children in group B (P < 0.01), while the differences of the remaining 4 items in guardians of children between two groups were not statistically significant (P>0.05). Conclusion Arousing the enthusiasm of village vaccination staff is the focus of preventive intervention for left-behind children.It is suggested that the peer education should be introduced into the families of left-behind children to carry out corresponding propaganda and education, to strengthen the care and input to the vaccination work of left-behind children.
2020, 45(7): 930-932, 938.
doi: 10.13898/j.cnki.issn.1000-2020.07.024
Abstract:
Objective To analyze the occurrence and risk factors of infection in inpatients, and explore the effective measures to control hospital infection. Methods The electronic medical records of 13 027 discharged patients from January 2015 to December 2016 were retrospectively analyzed.Based on the results of relevant report of clinician and investigation of full-time staff in infection department, the incidence rate of infection and its influencing factors were analyzed. Results The incidence rate of infection was 2.70% (352/13 207).The incidence rates of infection in 2015 and 2016 were 2.89% and 2.93%, respectively, and the difference of which was not statistically significant (P>0.05).The main departments of infection were ICU, urology and neurology.The most common locations of infection were the upper respiratory tract, lower respiratory tract, urinary tract and gastrointestinal tract, and surgical incision infection also accounted for a certain proportion.In addition to fungi, 1 180 strains of pathogenic bacteria were isolated.The infection bacteria were mainly the gram negative bacteria, Escherichia coli, Klebsiella Pneumoniae, Pseudomonas aeruginosa and so on, and the gram negative bacteria accounted for 69.66% (822 strains).The results of logistic regression analysis showed that the ventilator use, tracheotomy, indwelling catheter and hemodialysis were the independent risk factors of hospital infection (P < 0.05 to P < 0.01). Conclusion To control hospital infection, the high-risk factors should be analyzed according to the hospital's situation, and then the prevention and control should be emphasized.The main measures of control infection include the strict implementing disinfection system, strengthening basic nursing work, rational use of antibiotics, and enhancing the hand hygiene compliance of doctors and patients.
2020, 45(7): 933-938.
doi: 10.13898/j.cnki.issn.1000-2020.07.025
Abstract:
ObjectiveTo analyze the development of various disciplines in Bengbu Medical College and provide theoretical basis and data support for discipline construction and development planning. MethodsThe Web of Science (WOS) documents, Essential Science Indicators (ESI) disciplines and potential disciplines of Bengbu Medical College from 2010 to 2020 were statistically analyzed using ESI and InCites database. ResultsA total number of 1 689 WOS documents were published by Bengbu Medical College from 2010 to 2020, the total citation frequency was 13 009, the citation frequency of each paper was 7.70, and 7 documents were highly cited.The total number of WOS documents was increasing year by year, and the category normalized citation impact of WOS documents in 2010 was more than 1, which exceeded the global average level.The clinical medicine of Bengbu Medical College ranked in the global top 1% of ESI.The distribution of the first authors of WOS documents in ESI discipline was relatively scattered, the influence factors of published journals were mostly in the range of 1-3, and the influence of cooperative documents, especially international cooperation documents was generally high.Among the ESI potential disciplines, "pharmacology and toxicology" had the highest potential value, which was the most likely to enter the top 1% of ESI in the future. ConclusionsThe overall scientific research level of Bengbu Medical College is gradually strengthened.We should further strengthen the balanced development of various disciplines, optimize the allocation of resources, improve the quality of documents, encourage scientific research cooperation, speed up the disciplines construction, and promote the rapid development of the school's double first-class construction.
2020, 45(7): 939-942.
doi: 10.13898/j.cnki.issn.1000-2020.07.026
Abstract:
ObjectiveTo analyze the status, research hotspot and trend of papers from authors and institutions of domestic core journals in recent 20 years based on bibliometrics analysis, to provide reference for researchers to understand the current situation and development trend of Internet addiction. MethodsThe Chinese databases were searched by computer, and the literatures about Internet addiction were retrieved from January 2001 to April 2020.CiteSpace software was used to conduct bibliometric analysis on the research authors, institutions, clustering words, mutation words and so on, and the knowledge map was drawn. ResultsThe number of research papers in the field of Internet addiction in China showed a rapid increase from 2001 to 2008.The research on Internet addiction experienced two stages of development from 2001 to 2008, and from 2009 to now.At present, the research hotspots mainly focused on the object, influencing factor, mental health and behavior education of Internet addiction.With the development of deepening research, there emerged some institutions and authors with high influence in the field of Internet addiction. ConclusionsDrawing the knowledge map of relevant literatures in the field of Internet addiction using CiteSpace software can fully display the research direction, hotspot and development trend in the field of Internet addiction.
2020, 45(7): 943-945.
doi: 10.13898/j.cnki.issn.1000-2020.07.027
Abstract:
ObjectiveTo explore the application of 3D printing technology combined with Sandwich teaching method in clinical practice in oncology surgery department. MethodsSixty-four students who practiced in oncology surgery department were randomly divided into observation group and control group (32 students in each group).The control group received Sandwich teaching method, while the observation group received 3D printing technology combined with Sandwich teaching method.The theoretical and practical scores, satisfaction of self-evaluation (learning interest, independent thinking ability, social practice ability) and satisfaction with teachers' teaching were compared between the two groups. ResultsThe scores of theory, frontier knowledge, history collection and physical examination, disease diagnosis and differential diagnosis in observation group were significantly higher than those in control group (P < 0.01).The satisfaction of learning interest, independent thinking ability, social practice ability and satisfaction with teachers' teaching in observation group were higher than those in control group (P < 0.05 to P < 0.01). ConclusionsIn the clinical practice teaching in oncology surgery department, the application of 3D printing technology combined with Sandwich teaching method can effectively improve the learning efficiency of clinical students, which is worthy of promotion in clinical teaching.
2020, 45(7): 946-949, 953.
doi: 10.13898/j.cnki.issn.1000-2020.07.028
Abstract:
ObjectiveTo analyze the implementation method and effect of excellent physician training program in the clinical medicine specialty of local medical colleges. MethodsA total of 559 students from grade 2012 to 2014 studying in the First Affiliated Hospital of Bengbu Medical College were selected as the research objects.The students in the teaching reform class received excellent physician training program, and students in the ordinary class received conventional teaching and training program.Based on the results of "the first stage of empirical research on clinical classification examination of physician qualification examination" organized by the National Medical Examination Center, the scores of theoretical test and skill test between two classes were compared, and Pearson correlation analysis was conducted to analyze the correlation between skills and scores of different modules of written examination. ResultsThere was no significant difference in the teaching performance between the two classes in grade 2012 (P>0.05);the total theoretical scores in teaching reform class were significantly higher than that in ordinary class in grade 2013 (P < 0.01), but there was no significant difference in the total scores of skills between the two classes in grade 2013 (P>0.05);there was no significant difference in the teaching performance between the two classes in grade 2014 (P>0.05).Pearson analysis showed that the skills were positively correlated with scores of different modules of written examination in the two classes in grade 2012 and grade 2013 (P < 0.05);the skills were positively correlated with the total theoretical scores, the scores of different modules of basic medicine and clinical medicine of written examination in the two classes in grade 2014 (P < 0.05), but the skills were not significantly correlated with the scores of different modules of medical humanity and preventive medicine in grade 2014 (P>0.05).There was no significant difference in the scores of each theoretical score and total scores of skills between the two classes (P>0.05), and the total theoretical scores in teaching reform class were higher than that in ordinary class (P < 0.05). ConclusionsThe excellent physician training program can improve students' comprehensive performance, which should be widely applied and promoted in medical colleges.
2020, 45(7): 950-953.
doi: 10.13898/j.cnki.issn.1000-2020.07.029
Abstract:
ObjectiveTo explore the effects of early initiation of language memory trace management on aphasia after hypertensive cerebral hemorrhage. MethodsEighty-two patients with aphasia after hypertensive cerebral hemorrhage were divided into the observation group and control group according to the postoperative management methods (41 cases in each group).The control group was intervened with traditional language rehabilitation training, and the observation group was intervened with early initiation of language memory trace management.Before and after 15 and 30 days of intervention, the language function, language communication ability, aphasia and clinical effects in two groups were evaluated using the aphasia battery of Chinese, Chinese functional communication (CFCP), aphasia quotient (AQ) index and examination of Chinese language aphasia in Peking University, respectively. ResultsThe differences of the ability scores of expression, understanding, reading and writing before intervention were not statistically significant between two groups (P>0.05), and the scores of all items in observation group were significantly higher than those in control group after 15 and 30 days of intervention (P < 0.01).There was no statistical significance in CFCP score and AQ index between two groups before intervention (P>0.05).With the prolongation of intervention time, the CFCP score and AQ index in two groups significantly increased (P < 0.01), and the CFCP score and AQ index in observation group were significantly higher than those in control group after 15 and 30 days of intervention (P < 0.01).The total effective rate of treatment in observation group (97.56%) was significantly higher than that in control group (58.54%) (P < 0.01). ConclusionsThe early initiation language memory trace can make the patients with aphasia after hypertensive cerebral hemorrhage get the standard and effective rehabilitation management, and promote the recovery of language function.
2020, 45(7): 954-958.
doi: 10.13898/j.cnki.issn.1000-2020.07.030
Abstract:
ObjectiveTo explore the influence of social support and family function on the mental state of pregnant women in late pregnancy. MethodsThe social support, family function and mental state of 580 pregnant women in late pregnancy were evaluated using the social support rating scale, family care index, self-rating anxiety scale (SAS), and self-rating depression scale (SDS). ResultsThe SAS and SDS score of pregnant women in late pregnancy were (45.36±9.89) and (52.19±12.01), respectively, which was significantly higher than those of the domestic norm (P < 0.01).The differences of SAS in pregnant women in late pregnancy with different pregnancy times, family per capita monthly income and poor pregnancy history were statistically significant (P < 0.01), and the differences of SDS in pregnant women in late pregnancy with whether employed and adverse pregnancy history were statistically significant (P < 0.01).The average score of social support and total family function score of pregnant women in late pregnancy were (41.25±7.23) and (7.56±1.54), respectively.The results of multiple linear regression results showed that subjective support and total family function scores were negatively correlated with the SAS scores in pregnant women in late pregnancy (P < 0.01 and P < 0.05).The total family function score, poor maternal history and subjective support were negatively correlated with the SDS scores in pregnant women in late pregnancy (P < 0.05 to P < 0.01). ConclusionsThe social support and family function have a great impact on the mental state of pregnant women in late pregnancy.Improving the level of social support, and maintaining the good family function are conducive to the relief of adverse mood and improve mental health in pregnant women.
2020, 45(7): 958-960.
doi: 10.13898/j.cnki.issn.1000-2020.07.031
Abstract:
ObjectiveTo investigate the effects of the education of sexual knowledge on quality of life and sexual function in young and middle-aged male patients treated with coronary percutaneous coronary stent implantation. MethodsSixty-two young and middle-aged male patients treated with percutaneous coronary stent implantation were randomly divided into the control group and observation group.The health education of coronary heart disease-related knowledge was implemented in control group, and the knowledge of coronary heart disease and sex life safe were regularly released to the observation group using WeChat based on the control group.The quality of life in two groups after 3 months of operation were investigated using the World Health Organization Quality of Life Measurement Scale (WHOQOL-BREF), the sexual life in two group from the third months after operation was investigated, and the sexual function in two groups was evaluated using the International Assessment of Erectile Function (IIEF-5). ResultsThe differences of the quality of life (including psychology and social relations fields) after 3 months of percutaneous coronary stent implantation were statistically significant (P < 0.05 and P < 0.01).The number of patients starting sexual life in observation group after 3 months of operation was higher than that in control group (P < 0.05).The number of patients with erectile dysfunction in observation group was less than that in control group (P < 0.05). ConclusionsThe education of sexual knowledge in young and middle-aged male patients treated with percutaneous coronary stent implantation can improve the quality of life, start sexual life earlier and reduce erectile dysfunction.It is worthy of clinical promotion.
2020, 45(7): 961-964, 967.
doi: 10.13898/j.cnki.issn.1000-2020.07.032
Abstract:
ObjectiveTo explore the effects of nursing intervention based on quantitative evaluation strategy on health behavior and therapeutic effects of diabetes mellitus patients. MethodsOne hundred and eight patients with diabetes mellitus were divided into the control group (56 cases, first admission) and observation group (52 cases, later admission) according to the order of admission.The control group was nursed with routine nursing, and the observation group were nursed with intervention based on quantitative evaluation strategy.The health behavior in two groups was evaluated using the diabetes self-care ability scale and the diabetes quality of life specific scale before intervention and after 6 months of following up, and the levels of blood glucose and glycosylated hemoglobin were compared between two groups. ResultsBefore intervention, there was no statistical significance in the scores of self-care ability and quality of life, and levels of blood glucose and glycosylated hemoglobin between two groups (P>0.05).After intervention, the scores of self-care ability and quality of life, and levels of blood glucose and glycosylated hemoglobin of patients in observation group were significantly higher than those in control group (P < 0.05 to P < 0.01). ConclusionsThe nursing intervention based on quantitative evaluation strategy can improve the health behavior, self-care ability and quality of life of diabetic patients.
2020, 45(7): 965-967.
doi: 10.13898/j.cnki.issn.1000-2020.07.033
Abstract:
ObjectiveTo investigate the effects of new position in intrahospital transport of non-traumatic coma patients, and explore the appropriate nursing position during the transport. MethodsFifty non-traumatic coma patients from January to June 2018 and 50 cases from July to December 2018 were divided into the control group and observation group, respectively.The control group and observation group were nursed with the conventional position and new position (head height of 20° to 30° and side lying at 30° to 60°), respectively.The mean arterial pressure, heart rate and position tolerance time, nursing adverse events and satisfaction of patients' family were compared between two groups. ResultsThere was no statistical significance in the mean arterial pressure and heart rate between two groups at admission (P>0.05).The position tolerance time, incidence rate of nursing adverse events and family satisfaction in observation group were longer, lower and better than those in control group, respectively (P < 0.05). ConclusionsThe new position is a suitable nursing position in the transport of non-traumatic coma patients in emergency, and helpful to reduce the incidence rate of nursing adverse events and improve the satisfaction of patients' family.
2020, 45(7): 968-972.
doi: 10.13898/j.cnki.issn.1000-2020.07.034
Abstract:
ObjectiveTo analyze the related influencing factors of nursing on the occurrence of urinary incontinence after electroprostatectomy, in order to provide guidance for clinical nursing. MethodsA total of 111 patients treated with electroprostatectomy were selected.The general data, international prostate symptom score, compliance assessment of levator anal muscle training, assessment of urinary incontinence in all cases were investigated, and the related risk factors of urinary incontinence were analyzed. ResultsThe incidence rate of urinary incontinence was 32.43% after the removal of catheter.The incidence rate of urinary incontinence after 1 and 3 months of operation were 18.01% and 7.21%, respectively.The results of logistic regression analysis showed that the age >70 years old, indwelling catheter time < 3 days or >7 days, poor compliance with levator anal muscle training before or after surgery were the risk factors of urinary incontinence after electroprostatectomy (P < 0.05 to P < 0.01). ConclusionsAdvanced age, too short or too long indwelling time and poor compliance of levator anal muscle training are the main factors of urinary incontinence after electroprostatectomy, the nursing measures should be taken to urge levator anal muscle training.
2020, 45(7): 972-976.
doi: 10.13898/j.cnki.issn.1000-2020.07.035
Abstract:
ObjectiveTo explore the correlations among work performance, work immersion and professional identity in operating room nurses. MethodsNinety-six nurses in operating room were selected, and the levels of work performance, work immersion and professional identity of the nurses were evaluated suing the work performance scale, work immersion experience questionnaire and professional identity scale. ResultsThe levels of work performance, work immersion and professional identity of nurses in operating room were (73.68±9.43), (108.90±18.47) and (96.37±14.42), respectively.The scores of work performance and professional identity of operating room nurses aged 30-39 years were significantly higher than those of other age nurses (P < 0.05).The higher the educational background and monthly income were, the higher the work performance, work immersion and professional identity scores of operating room nurses were (P < 0.05).The scores of work performance, work immersion and professional identity of nurses with 5-10 years of service were significantly higher than those of nurses with less than 5 years of service (P < 0.05).The higher the number of night shifts per week was, the lower the scores of work performance, work immersion and professional identity of operating room nurses were (P < 0.05).The scores of work performance, work immersion and professional identity of enrolled nurses were significantly higher than those of contract nurses (P < 0.05).The total score of work performance was positively correlated with the total scores of motivation, focus on current tasks, action and consciousness integration and work immersion (P < 0.05), and positively correlated with the total scores of occupational cognitive evaluation, coping with occupational setbacks, occupational self-reflection and occupational identity (P < 0.05). ConclusionsThe work performance of nurses in operating room is positively correlated with the work immersion and professional identity.It is suggested that the hospital managers should improve the levels of work immersion and professional identity of nurses in operating room for improving the task performance.
2020, 45(7): 977-981.
doi: 10.13898/j.cnki.issn.1000-2020.07.036
Abstract:
ObjectiveTo investigate the status of depression and its influencing factors in maintenance hemodialysis patients, and provide a basis for improving depression symptoms. MethodsA total of 209 patients with maintenance hemodialysis from three grade AAA and above hospitals in Beijing were investigated using the general data questionnaire, self-rating depression scale (SDS), functional assessment of chronic illness therapy-fatigue (FACIT-F), and Athen's insomnia scale (AIS). ResultsThe incidence rate of depressive symptom in maintenance hemodialysis patients was 40.2%.The results of logistic regression showed that the fatigue and sleep disorders were the independent risk factors of depression in maintenance hemodialysis patients (P < 0.05). ConclusionsThe incidence rate of depressive symptoms in maintenance hemodialysis patients is high.In clinical work, it is necessary to strengthen the observation of mental state.The exercise can improve the symptom of fatigue during hemodialysis, and the physics or medication can improve sleep disorders, which can improve the depressive symptoms and quality of life of patients with maintenance hemodialysis.
2020, 45(7): 985-988.
doi: 10.13898/j.cnki.issn.1000-2200.07.038
Abstract:
Objective:To explore the intervention effects of the group psychology counseling based on the Satir pattern on the compassion fatigue in nurses of operating room. Methods:A total of 96 nurses in operating room were tutored using the group psychology counseling based on the Satir pattern.The compassion fatigue condition and job satisfaction of nurses were evaluated using the professional quality of life scale and Mueller/McCloskey satisfaction scale (MMSS) before and after intervention. Results:The scores of the compassion satisfaction, occupational burnout, secondary traumatic stress and compassion fatigue in nurses of operating room after intervention were significantly lower than those before intervention (P < 0.01).The scores of all items in MMSS in nurses of operating room after intervention were significantly higher than those before intervention (P < 0.01). Conclusions:The group psychology counseling based on the Satir pattern can effectively improve the compassion fatigue condition, physical and psychological health and job satisfaction degree.
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