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2021 Vol. 46, No. 5
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2021, 46(5): 561-565.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.001
Abstract:
ObjectiveTo investigate the effect of folate deficiency on the proliferation, apoptosis, expression of spindle assembly checkpoint-related proteins, and its mechanism in L02 cells. MethodsL02 cells were cultured with different concentrations of folate(2 000, 200, 20, 0 nmol/L) for 2 weeks.Then the morphology of L02 cells was observed by inverted microscope, the cell cycle and apoptosis were detected by flow cytometry, cell proliferation was measured by CCK8, the expressions of Mad2, Bub1, BubR1 mRNA were detected by fluorescence quantitative PCR, and the expressions of Mad2, Bub1, BubR1 protein were analyzed by Western blotting. ResultsCompared with the normal control group, folate deficiency made L02 cells to become larger and irregular in shape, reduced the cell viability(P < 0.01), induced S-phase block(P < 0.05), promoted apoptosis(P < 0.05), and upregulated the mRNA and protein expressions of Mad2, Bub1, BubR1 in L02 cells(P < 0.01). ConclusionsIn the culture L02 cells, it induces folate deficiency at 200 nmol/L folate, which causes impaired spindle assembly checkpoint function, abnormal cell proliferation, and even apoptosis in severe deficiency.
2021, 46(5): 566-569.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.002
Abstract:
ObjectiveTo investigate the role of miR-143 in renal cell carcinoma, the effect of sunitinib on the expression of miR-143 and its association with cell proliferation and invasion. MethodsThe human renal carcinoma 786-O cells were divided into control group, miR-143 group, sunitinib group and co-action group.The negative control sequence was transfected into the cells of control group, the miR-143 sequence was transfected into the cells of miR-143 group, sunitinib group cells were treated with sunitinib for 48h, the co-acting group was transfected miR-143 sequence and treated with sunitinib for 48h.Proliferation and invasion of 786-O cells were detected by MTT and transwell experiment, miR-143 RNA expression was detected by qRT-PCR, DNA methyltrans-ferase3B(DNMT3B).The expressions of p-Akt-S473 protein were detected by Western blotting. ResultsThe human renal cancer 786-O cells with stable and high expression of miR-143 were successfully constructed.The expression of miR-143 was increased in the miR-143 transfected group(P < 0.01).The IC50 value in 786-O cells with the treatment of sunitinib for 48 h was 6 μmol/L, which was selected as the drug concentration in the subsequent experiment.The expression of miR-143 in 786-O cells was increased after the treatment of sunitinib for 48 h(P < 0.01).Cell survival rate, cell invasion number, expressions of DNMT3B and p-Akt-S473 protein in miR-143 and sunitinib group were all lower than control group and higher than co-action group(P < 0.05 to P < 0.01). ConclusionsmiR-143 reduced the proliferation and invasion capacity of 786-O cells, which may be related to the decreased expression of DNMT3B and p-Akt regulated by miR-143.Sunitinib may inhibit the proliferation and invasion of 786-O cells by upregulating miR-143.
2021, 46(5): 570-573, 578.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.003
Abstract:
ObjectiveTo investigate the role of spinal colony-stimulating factor 1(CSF1) in morphine tolerance to analgesia. MethodsMale Sprague-Dawley rats with successful intrathecal catheter were randomly divided into four groups(n=15): 0.9% sodium chloride solution group(NS), morphine group(MOR), CSF1R inhibitor PLX3397 group(PLX3397) and morphine plus PLX3397 group(MOR+ PLX3397).A morphine tolerance model of rats was induced by intrathecal injection of 15 μg morphine once daily for 7 consecutive days in MOR and MOR+PLX3397 group.PLX3397 was administered intragastrically in PLX3397 and MOR+PLX3397 group, 0.9% sodium chloride solution was administered intrathecally in NS and PLX3397 group.The role of CSF1 on morphine antinociceptive tolerance was explored by %MPETFL and %MPEMWT.Immunohistochemistry assay was applied to detect the expression of IBA-1.Western blotting was used to evaluate the change of spinal CSF1 expression. ResultsIntrathecal injection of morphine for 7 days, %MPE in MOR group showed progressive decrease, while %MPE in MOR+PLX3397 group were significantly increased as compared with MOR group on day 3, 5, 7 after chronic morphine(P < 0.05);There was no significant difference in %MPE between PLX3397 and NS group(P>0.05).on day 7 after chronic morphine, the expression of IBA-1 in MOR group was significantly up-regulated as compared with NS group(P < 0.05), while the expression of IBA-1 in MOR+PLX3397 group was significantly down-regulated as compared with MOR group(P < 0.05);the expression of CSF1 in MOR and MOR+PLX3397 group was significantly up-regulated as compared with NS group(P < 0.05). ConclusionsCSF1 in the spinal cord can be involved in the development of tolerance to morphine-induced analgesia.Inhibition of CSF1 may provide a new therapeutic target for morphine tolerance to analgesia.
2021, 46(5): 574-578.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.004
Abstract:
ObjectiveTo analyze the relationship between the clinical characteristics, global registration of acute coronary event score(GRACE risk score), thrombolysis in myocardial infarction risk score(TIMI risk score) and clinical prognosis in female patients with acute coronary syndrome(ACS). MethodsSix hundred and one ACS patients diagnosed using coronary angiography from October 2018 to July 2019 were selected.The general clinical data, laboratory examination results, imaging data and interventional therapy data of all patients were collected.According to the gender, the patients were divided into the female group and male group.According to the GRACE risk score, the patients were divided into the high-risk, medium-risk and low-risk groups.According to the TIMI risk score, the patients were divided into the high-risk, medium-risk and low-risk groups.The number of vascular lesions and Gensini score in all patients were calculated.All ACS patients were followed up by telephone or outpatient for an average of 12 months after discharge.A questionnaire was designed to calculate the occurrence of Maces events.According to the Maces events, the patients were divided into the Maces group and non-Maces group. ResultsAmong the 601 patients, there were 236 females(39.3%) and 365 males(60.7%) with an age of(64.8±10.3) years.The results of baseline data showed that the age, proportion of unstable angina pectoris, proportion of combined diabetes, total cholesterol and low density lipoprotein cholesterol levels in female patients were higher than those in male patients(P < 0.05 to P < 0.01).The proportion of acute myocardial infarction and early coronary heart disease, smoking, serum creatinine and uric acid in female patients were lower than those in male patients(P < 0.05 to P < 0.01).There was no statistical significance in the proportion of perioperative medication, hypertension, cerebral infarction and atrial fibrillation between female and male patients(P>0.05).The results of Grace risk score showed that there was no statistical significance in the proportion of low-risk, medium-risk and high-risk groups between two groups(P>0.05).The results of TIMI risk score showed that the proportion of female patients in the low-risk group was lower than that of male patients(P < 0.05).The results of coronary angiography showed that there was no statistical significance in the number of vascular lesions and Gensini score between two groups(P>0.05).The results of Maces events showed that there was no statistical significance in the proportion of Maces events between two groups(P>0.05).The results of binary logistic regression analysis showed that the age and blood glucose were the independent risk factors of Maces in female patients(P < 0.01), while the smoking and low density lipoprotein cholesterol were the independent risk factors of Maces in male patients(P < 0.01 and P < 0.05). ConclusionsThe onset of ACS in female patients is later than that in male patients, but they are more likely to be associated with abnormal blood glucose and lipid, and the degree of vascular disease, clinical risk stratification and prognosis after onset are not significantly different from those in male patients.Therefore, the attention should be paid to the screening, prevention and treatment of female patients.
2021, 46(5): 579-582.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.005
Abstract:
ObjectiveTo compare the incidence rate of long-term adverse events between radiofrequency ablation and oral drug therapy for atrial fibrillation(AF), and further analyze the predictive value of C reactive protein(CRP) in long-term adverse events of AF patients. MethodsThe patients with AF in the First Affiliated Hospital of Bengbu Medical College were selected, 89 patients were treated with catheter ablation, and 107 patients were treated with oral medication.Two groups were followed up for 18 months, and the incidence rate of chronic stroke, bleeding events and all-cause death in two groups were evaluated.The indicators in two groups were evaluated according to the pre-admission related indicators.The Cox regression analysis was used to predict the risk factors of long-term adverse events, and whether CRP for a predictor of AF long-term adverse events was evaluated. ResultsThe long-term stroke, bleeding events, all-cause death and all events in the patients treated with radiofrequency ablation were less than those in the patients treated with drug.The adverse events time in the radiofrequency ablation group was little compared with in the drug therapy group, but the difference of which was not statistically significant(P>0.05).The CRP was an independent predictor of long-term adverse events in AF patients, and the serum CRP ≥ 6.4 mL/L was associated with the incidence rate of long-term adverse events in AF patients. ConclusionsThe CRP level can be used as a predictor of long-term adverse events, and the high-risk population of patients with AF can be screened using CRP level.
2021, 46(5): 583-586.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.006
Abstract:
ObjectiveTo explore the clinical value of laparoscopic hepatectomy in the treatment of hepatocellular carcinoma. MethodsThe clinical data of 169 patients with the pathological diagnosis of hepatocellular carcinoma were analyzed retrospectively, and the clinical effects of laparoscopy and laparotomy in the treatment of hepatocellular carcinoma were compared. ResultsThe operation time in the laparoscopy group was longer than that in the laparotomy group(P < 0.05), while the intraoperative blood loss and postoperative hospital stay in the laparoscopy group were significantly lower than those in the laparotomy group(P < 0.01).The utilization rate of postoperative analgesics in the laparoscopy group was significantly lower than that in the laparotomy group(P < 0.01).The levels of peripheral blood albumin in the laparoscopy group were higher than that in open group on the 3rd and 7th day after operation.The levels of ALT and AST in laparoscopy group were lower than those in the laparotomy group on the 3th, 7th and 30th day after operation.There was no significant difference in serum albumin levels, overall incidence of postoperative complications, total bilirubin changes and tumor recurrence rate within 2 years after operation between the two groups. ConclusionsLaparoscopic surgery for hepatocellular carcinoma has the same therapeutic effect as open surgery with shorter hospital stay and faster recovery.
2021, 46(5): 587-590.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.007
Abstract:
ObjectiveTo evaluate the clinical value of the superficial inferior abdominal artery perforator flap in oral cancer patients by comparing the long-term complications of the donor site between the superficial inferior abdominal artery perforator flap and forearm flap. MethodsThe clinical data of 15 oral cancer patients(observation group) treated with free superficial inferior abdominal artery perforator flaps(superficial inferior epigastric artery perforator flaps or superficial circumflex iliac artery perforator flaps) for extensive resection of lesions and 15 oral and maxillofacial soft tissue defect patients(control group) treated with forearm flaps to repair at the same time were retrospectively analyzed.The long-term complications of the donor site(including paresthesia, hyperplasia of scar and pigmentation) were compared between two groups, and the long-term functional recovery of the donor site was evaluated in two groups. ResultsIn the observation group, the donor wound was directly pulled and sutured after stealth separation, and only linear scar was left after surgery, which had little effect on aesthetics and function.In the control group, the skin grafting was performed on the donor wounds, and the postoperative hyperplasia and hyperpigmentation of scars were obvious.The comparison results of the subjective feelings of patients in the donor site after skin flap surgery showed that there was no statistical significance in the decrease of muscle strength between two groups(P>0.05), and the paresthesia and subjective evaluation of the donor site appearance in observation group was significantly better than those in control group(P < 0.01).In the objective examination of the sensation, function and appearance of the donor site of patients in two groups, the muscle strength decreasing and paresthesia in observation group were better than those in control group(P < 0.05 and P < 0.01), and the color, thickness, vascular distribution, flexibility and total score of scar in observation group were also significantly better than those in control group(P < 0.01). ConclusionsThe superficial inferior abdominal artery perforator flap is a good choice for the repair of oral and maxillofacial soft tissue defects, which has less complications at the donor site and less influence on the appearance and function of the donor site.
2021, 46(5): 591-594.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.008
Abstract:
ObjectiveTo explore the predictive value of the mean platelet volume-to-lymphocyte ratio(MPVLR) in the severity of acute cerebral infarction. MethodsA total of 109 patients with acute cerebral infarction were retrospectively analyzed, and divided into the mild group(n=64) and moderate-severe group(n=45) according to the NIHSS score.The MPVLR was calculated according to the blood routine indexes of two groups.The influencing factors of acute cerebral infarction were analyzed using dichotomous logistic regression, and the predictive value of MPVLR level on admission in the severity of acute cerebral infarction was evaluated using ROC curve. ResultsThe MPVLR and monocyte counts in mild group were lower than those in moderate group(P < 0.05).The results of binary logistic regression analysis showed that the increasing of MPVLR level on admission was an independent predictor of acute cerebral infarction.The results of ROC curve showed that the area under the curve of MPVLR predicting the severity of acute cerebral infarction was 0.745(95%CI: 0.653~0.824), and the best cutoff value, sensitivity and specificity were 5.36, 80.0% and 62.5%, respectively. ConclusionsThe MPVLR has certain predictive value in judging the severity of acute cerebral infarction.
2021, 46(5): 595-598.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.009
Abstract:
ObjectiveTo investigate the expression level of interleukin(IL)-32 in esophageal squamous cell carcinoma, and its relationship with the curative effects after radiotherapy. MethodsThe clinical data of 95 patients with esophageal squamous cell carcinoma were retrospectively analyzed.The expression levels of IL-32 in patients with esophageal squamous cell carcinoma were detected using immunohistochemistry.According to the expression level of IL-32, the patients were divided into the high expression group(41 cases) and low expression group(54 cases).The clinical features and prognosis were compared between two groups. ResultsThere was no statistical significance in the gender, age, tumor location and chemotherapy between two groups(P>0.05), while the difference of the tumor differentiation degree between two groups was statistically significant(P < 0.05).The results of Kaplan-Meier survival analysis showed that the difference of the prognosis between two groups was statistically significant(P < 0.05).The results of Cox multivariate analysis showed that the combined chemotherapy and high expression of IL-32 were the independent influencing factors of prognosis in patients with esophageal squamous cell carcinoma(P < 0.05). ConclusionsThe high expression of IL-32 is an independent risk factor of prognosis in patients with intermediate esophageal squamous cell carcinoma after radiotherapy.
2021, 46(5): 598-601.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.010
Abstract:
ObjectiveTo explore the relationship between serum chemerin level in patients with type 2 diabetes mellitus(T2DM) and the development and progression of atherosclerosis. MethodsA total of 117 T2DM patients were selected.Based on carotid intima-media thickness(CIMT), they were divided into CIMT normal group(n=55) and CIMT thickening group(n=62).Based on visceral fat area(VFA), all the patients were divided into was divided into the abdominal obesity group(n=49), and non-abdominal obesity group(n=68).All study subjects had been recorded including their body mass index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP).Moreover, fasting blood glucose(FBS), fasting insulin(FINS), triglycerides(TG), total cholesterol(TC), low-density lipoprotein-cholesterol(LDL-C), high-density lipoprotein-cholesterol(HDL-C), glycosylated hemoglobin(HbA1c), C-reactive protein(CRP) and other indicators were detected.Furthermore, the serum chemerin concentrations were determined by the enzyme-linked immunosorbent assay, and the abdominal VFA and abdominal subcutaneous fat area(SFA) were measured by the bio-electrical inpedance analysis method.The differences of observation indexes between the two groups were compared.Pearson correlation analysis was conducted to explore the correlation between serum chemerin levels and the observation indexes.Binary logistics regression analysis was performed on the related factors of VFA and CIMT thickening. ResultsCompared with the CIMT normal group, the TC, TG, FINS, HOMA-IR, DBP, SBP, VFA, chemerin and SFA were all increased in the CIMT thickening group(P < 0.01).Compared with the non-abdominal obesity group, TC, TG, HOMA-IR, DBP, SBP, SFA, chemerin and CIMT was increased in the abdominal obesity group(P < 0.05).The results of correlation analysis showed that serum chemerin levels in patients with T2DM were positively correlated with SBP, DBP, TC, TG, BMI, FINS, HOMA-RI, VFA, SFA and CIMT(r=0.277, 0.303, 0.295, 0.299, 0.567, 0.317, 0.380, 0.795, 0.903, 0.565, P < 0.01).The results of binary logistic regression analysis showed that VFA, chemerin, FINS and SFA were the related factors of CIMT(P < 0.05 to P < 0.01);chemerin, SFA, HOMA-IR and CIMT were the related factors of VFA(P < 0.05). ConclusionsChemerin can promote the thickening of CIMT in patients with T2DM, which is a risk factor participating in the occurrence and development of atherosclerosis for patients with T2DM.
2021, 46(5): 602-605.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.011
Abstract:
ObjectiveTo explore the effects of the cine phase-contrast magnetic resonance imaging(PC-MRI) in evaluating the change of dynamics of cerebrospinal fluid(CSF) on the CSF dynamics in patients with Chiari malformation type Ⅰ(CMⅠ). MethodsSixteen healthy volunteers and 17 CMⅠ and syringomyelia patients were divided into the control goup and CMⅠgroup, respectively.The region between canium and neck of CMⅠ group was detected using PC-MRI scans before and after 12 months of operation, and the control group was checked only once.The changes of CSF velocity and flow at the central segment of midbrain aqueduct, exit segment of the fourth ventricle and second cervical spine level were analyzed. ResultsCompared with the control group, the peak flow velocity of CSF in each examined site in CMⅠ group increased(P < 0.05 to P < 0.01), and the overall flow decreased(P < 0.01).After operation, the peak velocity of CSF in CMⅠ group slowed significantly down(P < 0.01), and the flow increased(P < 0.01).The differences of the peak flow velocity and flow of CSF between the central segment of midbrain aqueduct and second cervical spine level among different prognosis patients were statistically significant(P < 0.05 to P < 0.01). ConclusionsThe improvement of CSF dynamics is related to the prognosis of patients.The application of PC-MRI in monitoring the dynamics of CSF is helpful to evaluate the prognosis of patients with CMⅠ complicated with syringomyelia.
2021, 46(5): 606-610.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.012
Abstract:
ObjectiveTo investigate the effects of the gene polymorphisms of CYP2C19, ABCB1 and PON1 on clopidogrel in the treatment of acute coronary syndromes(ACS) after percutaneous coronary intervention. MethodsA total of 98 patients treated with dual antiplatelet therapy of aspirin and clopidogrel after PCI were divided into the normal group(172 cases) and slow metabolism group(24 cases) according to the gene detection of CYP2C19, ABCB1 and PON1.The normal group and slow metabolism group were given the routine treatment and ticagrelor instead of control treatment, respectively.The platelet aggregation rates in two groups were measured after 5 days of continuous treatment, and the patients were followed up for 1 year.The major cardiovascular adverse events were recorded in two groups, and the platelet aggregation rates and clinical endpoint events were compared between two groups. ResultsThe differences of the platelet aggregation rates among the patients with different types of PON1、CYP2C19、ABCBl were statistically significant(P < 0.01).After 1 year of following up, the differences of the clinical endpoint events among the patients with different types of PON1、CYP2C19、ABCBl were not statistically significant(P>0.05).There were 16 cases with adverse cardiovascular events and 4 cases with severe bleeding events in the normal group, while there was not adverse cardiovascular events or severe bleeding events in the slow metabolic group, and the difference of which was not statistically significant(P>0.05). ConclusionsThe polymorphisms of CYP2C19, ABCB1 and PON1 genes are associated with clopidogrel resistance in CHD patients after PCI.Ticagrelor may have better clinical effectsin patients with slow metabolism.
2021, 46(5): 611-615.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.013
Abstract:
ObjectiveTo investigate the differences in the expression of hairy and enhancer of split 1(HES1) and human epidermal growth factor receptor 2(HER2) in accessory breast cancer(ABC) and routine mammary cancer(MC) and their relationship with clinicopathological features. MethodsThe clinical data, pathological data, expression of HES1 and HER2 in cancer tissues and follow-up data of 30 patients with ABC and 30 patients with MC were analyzed retrospectively and evaluated statistically. ResultsThe positive expression rates of HES1 and HER2 in ABC group were 30.00% and 53.33%, respectively, which were 40.00% and 40.00% in MC group, respectively, and the difference of which was not statistically significant(P>0.05).There were significant differences in the positive expression rate of HES1 between ABC group and MC group in different pathological type, histological grades, clinical stage, lymph node metastasis and triple negative breast cancer(P < 0.05 to P < 0.01).The positive expression rate of HES1 in ABC group was also statistically significant between patients with recurrence or not(P < 0.05).The positive expression rate of HER2 in ABC patients was statistically significant among different pathological type, histological grade, clinical stage, triple negative breast cancer and recurrence or not(P < 0.05 to P < 0.01).The positive expression rate of HER2 in MC patients was statistically significant among different pathological type, clinical stage, lymph node metastasis or not and triple negative breast cancer(P < 0.01). ConclusionsThe positive expression rates of HES1 and HER2 before surgery can reflect the pathological features of ABC and MC patients to a certain extent, and provide reference for the selection of reasonable surgical plans.
2021, 46(5): 615-618, 622.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.014
Abstract:
ObjectiveTo investigate the effects of selective head cooling(SHC) on the serum levels of key proteins and cytokines related to pyroptosis[including cysteinyl aspartate specific proteinase-1(Caspase-1), interleukin(IL)-1β and IL-18] in neonates with hypoxic-ischemic encephalopathy(HIE) in order to understand the possible neuroprotective mechanism of SHC in the treatment of HIE. MethodsA total of 45 neonates with HIE and 10 normal neonates during the same period were divided into the HIE group and control group, respectively.The HIE group was subdivided into the mild HIE group(13 cases), moderate HIE group(20 cases) and severe HIE group(12 cases) according to clinical staging.According to the cooling therapy criteria, 32 cases moderate and severe HIE neonates were divided into the conventional treatment group(15 cases) and SHC group(17 cases).The serum levels of Caspase-1, IL-1β and IL-18 in all groups were detected using ELISA, and compared. ResultsThe serum levels of Caspase-1 and IL-1β in mild, moderate and severe HIE groups were higher than those in control group, and the levels of Caspase-1 and IL-1β increased with the aggravating of clinical staging of HIE(P < 0.05).The serum levels of IL-18 in moderate and severe HIE groups were higher than that in mild HIE group and control group(P < 0.05).The serum levels of Caspase-1, IL-1β and IL-18 in neonates with HIE were significantly positively correlated with the clinical staging of HIE(rs=0.820, 0.913 and 0.683, P < 0.01).There was no statistical significance in the serum levels of Caspase-1, IL-1β and IL-18 between SHC group and conventional treatment group before treatment(P>0.05).The serum level of Caspase-1 at 24 h and levels of Caspase-1, IL-1β and IL-18 at 48 h and 72 h of treatment in SHC group were significantly lower than those in conventional treatment group(P < 0.01).at 48 h and 72 h of treatment, the levels of Caspase-1, IL-1β and IL-18 in SHC group were lower than those at 0 h and 24 h(P < 0.05).The serum levels of Caspase-1, IL-1β and IL-18 in conventional treatment group at 48 h of treatment increased compared with at 0 h(P < 0.05), the levels of IL-1β and IL-18 at 72 h were still higher than that at 0 h(P < 0.05), while there was no statistical significance in the level of Caspase-1 between 72 h and 0 h(P>0.05). ConclusionsThe selective head cooling in the treatment of HIE can achieve neuroprotection by reducing the level of pyroptosis.
2021, 46(5): 619-622.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.015
Abstract:
ObjectiveTo analyze the correlation between lung ultrasound score(LUS) and clinical data of patients and explore its role in predicting postoperative pulmonary complications(PPC). MethodsSixty cases of elderly patients who underwent radical resection of lung cancer were divided into two groups: PPC group(n=25) and nPPC group(n=35) according to the PPC occurrence.Lung ultrasound examination was performed before surgery to calculate LUS.Preoperative oxygen partial pressure(PO2), oxygen saturation, respiratory rate, operation mechanical ventilation time, total hospital stay, postoperative hospital stay and the occurrence of PPC were recorded.The correlation between LUS and monitoring indicators was analyzed.ROC curve was used to evaluate the value of LUS in predicting the occurrence of PPC in patients. ResultsThe preoperative score of LUS in nPPC and PPC group was(12.34±1.88) and(14.88±2.22), respectively.LUS was positively correlated with age, PO2, oxygen saturation, respiratory rate, total length of hospital stay, postoperative length of hospital stay and PPC(P < 0.05 to P < 0.01).LUS, total hospital stay and postoperative hospital stay in PPC group was higher than that in nPPC group (P < 0.05 to P < 0.01).The point for LUS to predict the occurrence of PPC was 12.5 with the sensitivity of 88.0% and the specificity of 57.1%. ConclusionsLUS can quantitatively pre-evaluate the occurrence of PPC after radical resection of lung cancer in elderly patients, which helps to guide clinical diagnosis and treatment.
2021, 46(5): 623-626.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.016
Abstract:
ObjectiveTo explore the efficacy and safety of anlotinib in the treatment of advanced non-small cell lung cancer(NSCLC). MethodsThe clinical data of 50 advanced NSCLC patients treated with anlotinib were retrospectively analyzed.Forty-five patients were treated with anrotinib of third-line drug, and 5 patients were treated with fourth-line drug.The efficacy and safety of anlotinib were analyzed. ResultsForty-seven patients were investigated, and the complete response in 0 case, partial response in 2 cases(4.26%), stable disease in 24 cases(51.06%) and disease progression in 21 cases(44.68%) were found.The objective response rate(ORR) and disease control rate(DCR) were 4.3% and 55.3%, respectively.The median overall survival(mOS) and median progression-free survival(mPFS) were 8.6 months(95%CI 5.853-11.347) and 4.8 months(95%CI 2.904-6.696), respectively.The mOS and mPFS in elderly patients(≥ 60 years old) were 8.6 months(95%CI 5.853-11.347) and 5.8 months(95%CI 4.283-7.317), respectively.The adverse reactions caused by the use of amlotinib were basically tolerable, and the high incidence rate of adverse reactions included anorexia, hemoptysis, abnormal liver function, hand-foot syndrome and hypertension. ConclusionsAnlotinib is a viable option for third-line and above in patients with advanced NSCLC
2021, 46(5): 627-629, 634.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.017
Abstract:
ObjectiveTo compare the clinical effects between high-flow nasal cannula(HFNC) and non-invasive ventilation(NIV) in the treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD) complicated with type Ⅱ respiratory failure. MethodsSeventy-seven patients with COPD were randomly divided into the observation group(39 cases) and control group(38 cases).The observation group and control group were treated with HFNC and NIV, respectively.Two groups were treated with anti-inflammatory, spasmolysis, asthma and phlegm of comprehensive treatment.The blood gas analysis, CAT score, lung function and failure rate in two groups were compared between before and after treatment. ResultsThe PaCO2 and PaO2 in two groups after 24 h of treatment were lower higher than those before treatment(P < 0.05), and the PaCO2 and PaO2 after 72 h of treatment were lower and higher than those before treatment and after 24 h of treatment, respectively(P < 0.05).There was no statistical significance in the levels of pH, PaCO2 and PaO2 in two groups between before and after treatment(P>0.05).After treatment, the differences of the failure rate, CAT score, pulmonary function indexes(including the FEV1, FVC and FEV1/FVC) and failure causes(including treatment intolerance, deterioration of blood gas indexes and exacerbation of clinical symptoms) were not statistically significant between two groups(P>0.05). ConclusionsThe effects of HFNC and NIV in the treatment of AECOPD with type Ⅱ respiratory failure are similar.
2021, 46(5): 630-634.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.018
Abstract:
ObjectiveTo investigate the correlation of serum levels of lipoprotein a[LP(a)], low-density lipoprotein cholesterol (LDL-C), homocysteine(Hcy) and cystatin C(Cys C) with acute cerebral infarction(ACI), and their diagnostic value. MethodsThe neurological function scoring in 300 ACI patients(case group) were investigated using NHISS scale, and 70 medical examinees were set as the control group during the same period.The serum levels of glucose(GLU), cholesterol(CHOL), high-density lipoprotein cholesterol(HDL-C), triacylagly cerol(TG), LP(a), LDL-C, Hcy and Cys C were compared between two groups.According to NHISS score, the ACI patients were divided into the mild group(n=173), moderate group(n=89) and severe group(n=38), and the serum levels of LP(a), LDL-C, Hcy and Cys C among three groups were compared.The multi-factor model was established using multivariate logistic regression, and the ROC curve was drawn to evaluate the diagnostic value of alone and combination of LP(a), LDL-C, Hcy and Cys C for ACI. ResultsThe serum levels of GLU, CHOL, HDL-C, LP(a), LDL, Hcy and Cys C in case group were higher than those in control group(P < 0.05 to P < 0.01), and the difference of the level of TG between two groups was not statistically significant(P>0.05).The serum levels of LDL-C and Hcy in ACI mild group, moderate group and severe group gradually increased(P < 0.05);and the differences of the levels of LDL-C and Hcy among three groups was not statistically significant(P>0.05).The results of ROC analysis showed that the Hcy alone in the diagnosis of ACI had high accuracy(the area under ROC curve, sensitivity, specificity and Youden index were 0.799, 81.00%, 88.53% and 69.53%, respectively).The accuracy of combination of serum LP(a), LDL-C, Hcy and Cys C in the diagnosis of ACI was the highest(the area under ROC curve, sensitivity, specificity, Youden index were 0.841, 97.14%; 90.63%, 87.77% and 0.80, respectively). ConclusionsThe serum levels of LP(a), LDL-C, Hcy and Cys C are related to the occurrence and severity of ACI, and the LDL-C and Hcy are associated with the severity of ACI.The combined detection of LDL-C, Hcy and Cys C has a higher sensitivity and specificity for the diagnosis of ACI, which may become an early predictor biological indicating of ACI occurrence.
2021, 46(5): 635-638.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.019
Abstract:
ObjectiveTo investigate the correlation between abnormal fasting plasma glucose(FPG) level and Guillain-Barré syndrome(GBS), and to analyze whether elevated FPG level being an independent risk factor for poor short-term prognosis in patients with GBS. MethodsThe clinical data of 146 patients with GBS were retrospectively analyzed.According to the FPG level, the patients were divided into normal FPG group(n=90) and high FPG group(n=56).Gender, age, neurological signs, history of precursor infection, cranial nerve palsy, sensory disturbance, autonomic nerve involvement, difficulty breathing, total score of MRC and Hughes functional grading scale(HFGS) score were compared between the two groups.The differences of protein level, glucose level, protein-cell separation, Pandy test results in cerebrospinal fluid and electrophysiological data between the two groups were analyzed.According to the HFGS score at discharge, the patients were divided into mild group(HFGS score ≤ 3 points) and severe group(HFGS score>3 points).The relationship between FPG level and short-term prognosis of GBS was analyzed. ResultsThere were no significant differences in age, sex, history of precursor infection, sensory disturbance, decrease or absence of tendon reflex, meningeal irritation sign, neuroelectrophysiological classification and protein level, protein-cell separation, Pandy test results in cerebrospinal fluid between the two groups(P>0.05).The incidence of surgical trauma history, cranial nerve involvement, combination of autonomic nerve dysfunction, difficulty breathing, assisted-ventilation, Babinski sign, HFGS score of 5 and 6 at discharge, and glucose concentration in cerebrospinal fluid in normal FPG group were higher than those in high FPG group(P < 0.05 to P < 0.01), and MRC score at nadir was significantly lower than that in high FPG group(P < 0.01).Univariate analysis showed that age, cranial nerve involvement, autonomic nerve dysfunction, and high protein content, high FPG level, high serum C reactive protein level in cerebrospinal fluid were risk factors of poor short-term prognosis in GBS patients(P < 0.05 to P < 0.01);the cell number in cerebrospinal fluid was not significantly correlated with short-term prognosis in GBS patients(P>0.05).Multivariate logistic regression analysis showed that high age, cranial nerve involvement, and high protein level, high FPG level in cerebrospinal fluid were independent risk factors for poor short-term prognosis in GBS patients(P < 0.05 to P < 0.01). ConclusionsGBS patients with elevated FPG level are more severe, more likely to have cranial nerve involvement, autonomic nerve dysfunction, difficulty breathing, dependence on mechanical ventilation, and worse short-term prognosis.Elevated FPG level is an independent risk factor for poor short-term prognosis in patients with GBS.
2021, 46(5): 639-641.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.020
Abstract:
ObjectiveTo investigate the influencing factors of acute kidney injury(AKI) in patients with septic shock. MethodsA total of 144 patients with septic shock were divided into the AKI group and non-AKI group according to the incidence of AKI.The general data and clinical indicators between two groups were compared, and analyzed using the univariate analysis method.The items with significant difference were analyzed using the logistic regression analysis method to explore the influencing factors of AKI. ResultsThe differences of the combined diabetes, mean arterial pressure, glomerular filtration rate, levels of serum lactate, urea nitrogen and D-dimer, mechanical ventilation, blood purification therapy, maximum daily dose of furosemide were statistically significant(P < 0.05 to P < 0.01).The differences of the age, gender and body mass index between two groups were not statistically significant(P>0.05).The results of logistic regression analysis showed that the combined diabetes, mean arterial pressure, serum lactate level, mechanical ventilation and maximum daily dose of furosemide were the independent factors influencing AKI in patients with septic shock(P < 0.05 to P < 0.01). ConclusionsThe incidence rate of AKI is higher in patients with septic shock.The combined diabetes, mean arterial pressure, serum lactate level, mechanical ventilation, maximum daily dose of furosemide are the independent factors influencing AKI in patients with septic shock, and the clinical intervention measures should be taken early for high-risk patients.
2021, 46(5): 642-644, 648.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.021
Abstract:
ObjectiveTo observe the effects of low dose propofol or ketamine on cough in children treated with tonsillectomy after recovery from anesthesia. MethodsNinety ASA Ⅰ-Ⅱ patients scheduled by tonsillectomy were randomly divided into the propofol group(group P) and ketamine group(group K)(45 cases each group).The group P and group K were intravenously injected with low dose propofol(0.5 mg/kg) and ketamine(0.5 mg/kg) at the end of anesthesia, respectively.After the operation, the occurrence rates of cough in two groups were recorded at T0, T0-T1, T1-T2, T2-T3, T3-T4, T4-T5 and T5-T6[T0(at the time of extubation), T1(after 5 min of extubation), T2(after 10 min of extubation), T3(after 15 min of extubation), T4(after 20 min of extubation), T5(after 25 min of extubation) and T6(after 30 min of extubation)].The pain scores in two groups were recorded after 10 min, 20 min, 30 min, 1 h, 2 h, 4 h and 8 h of operation, respectively.The incidence rate of postoperative vomiting in two groups were recorded. ResultsThe incidence rates of cough in group P at each time-point were lower than that in group K, the pain scores in group P after 10 min 20 min 30 min of operation were higher than that in group K, and the incidence rate of postoperative vomiting in group P was lower than that in group K(P < 0.05 to P < 0.01). ConclusionsFor children treated with tonsillectomy, compared with 0.5 mg/kg of low-dose ketamine the intravenous injection of 0.5 mg/kg of low-dose propofol after anesthesia can effectively reduce the cough, and incidence rates of nausea and vomiting, but the analgesic effect of propofol is not as good as ketamine.
2021, 46(5): 645-648.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.022
Abstract:
ObjectiveTo compare the clinical effects between minimally invasive transthoracic occlusion guided by esophageal ultrasound and conventional repair in the treatment of ventricular septal defect(VSD) in children. MethodsEighty-nine VSD children treated with traditional thoracotomy repair and 85 VSD children treated with minimally invasive transthoracic occlusion guided by esophageal ultrasound were divided into the control group and observation group, respectively.The surgical situation, postoperative inflammatory factors, postoperative complications, postoperative recovery time and cardiac function indexes were compared between two groups. ResultsThe operation time in observation group was shorter than that in control group(P < 0.01), and the intraoperative blood transfusion amount in observation group(0 mL) was less than that in control group[(407.87±95.89)mL](P < 0.01).On the postoperative 1 to 3 days, the C-reactive protein level and leukocyte count in observation group were lower than those in control group(P < 0.01).The difference of the total incidence rate of postoperative complication between two groups was not statistically significant(P>0.05).The intubation time and hospital stay in observation group were shorter than those in control group(P < 0.01).After operation, the levels of LVEF, LVEDD and LVESD in two groups were significantly improved compared with those before operation(P < 0.01).After operation, the level of LVEF in observation group was higher than that in control group, and the levels of LVEDD and LVESD in observation group were lower than those in control group(P < 0.01). ConclusionsThe minimally invasive transthoracic occlusion guided by esophageal ultrasound in treating VSD of children can significantly shorten the operation time and reduce intraoperative blood transfusion amount.It is beneficial to reduce postoperative inflammatory reaction, reduce the risk of postoperative complications, accelerate the progress of postoperative rehabilitation and improve cardiac function.
2021, 46(5): 649-652.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.023
Abstract:
ObjectiveTo investigate the correlation between the calcification volume of carotid bifurcation on non-enhanced CT and the stenosis degree of internal carotid artery on digital subtraction angiography(DSA). MethodsThe imaging data of 29 patients with carotid artery scanning were retrospectively analyzed, including non-enhanced CT and DSA scanning.Calcified plaque of carotid bifurcation was segmented in CT image and volume was measured by 3D reconstruction software.The stenosis degree of internal carotid artery was evaluated by DSA, and the stenosis degree >40% was defined as "obvious stenosis".Pearson correlation analysis was used to analyze the correlation between calcification volume and stenosis degree.The ROC curve was used to evaluate the value of calcification volume and predict the obvious stenosis. ResultsThe calcification volume of carotid bifurcation was(0.17±0.10) cm3 in all 29 patients.Among them, 25 patients(86.2%) had stenosis of internal carotid artery with different degrees, in which 17 patients had obvious stenosis.Correlation analysis showed that the calcification volume on non-enhanced CT was moderately correlated with the carotid stenosis degree in DSA(r=0.455, P < 0.05).The ROC curve showed that the cut-off value of the calcification volume used to predict obvious stenosis was 0.07 cm3(P < 0.01) with the sensitivity of 100.0% and specificity of 66.7%. ConclusionsThe calcification volume of carotid bifurcation in non-enhanced CT is related to the stenosis degree of internal carotid artery.The volume over 0.07 cm3 can be used as a screening index to predict obvious stenosis.
2021, 46(5): 652-656.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.024
Abstract:
ObjectiveTo explore the value of multi-modality radiomics based on mammography and MRI in predicting the preoperative lymph node metastasis in mass type breast cancer. MethodsThe clinical data of 111 mass type breast cancer patients(114 lesions) detected by mammography and MRI were collected.All patients were randomly divided into the training group and validation group according to the ratio of 8:2.The radiomics features were segmented and extracted from all images.The minimum and maximum normalization, Select K Best and least absolute shrinkage and selection operator were used to obtain the optimal features to establish the mammography, MRI and mammography combined with MRI prediction model.The efficiency of model was evaluated using the area under receiver operating characteristic(ROC) curve(AUC). ResultsThe AUC values of the mammography, MRI and mammography combined with MRI model in the training group and validation group were(0.76, 0.82 and 0.89, respectively) and(0.74, 0.81 and 0.88, respectively).The AUC value and efficiency of mammography combined with MRI model were the highest.The lesion size in positive axillary lymph node group was greater than that in negative axillary lymph node group(P < 0.01). ConclusionsThe multi-modality radiomics model based on mammography combined with MRI can better predict the preoperative lymph node metastasis of mass type breast cancer.
2021, 46(5): 657-660.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.025
Abstract:
ObjectiveTo make a mid-term follow-up for patients with cirrhosis and hypersplenism after partial splenic embolization(PSE), and to compare the changes of CT, peripheral blood cells and complications in embolization area and spleen tissue of patients with different percentage of embolic volume. MethodsForty-three patients with cirrhosis and hypersplenism treated with PSE were divided into group A(≤ 50%) and group B(>50%) according to the percentage of splenic embolization volume.The CT manifestations of upper abdomen, the changes of peripheral blood cells and the occurrence of complications were compared between the two groups before operation, 1 week, 4 weeks, 10 weeks and 6 months after operation. ResultsLiquefaction necrosis was found in 1 case in group A at 4 weeks after operation and repaired at 6 months after operation; 5 cases of liquefaction necrosis at 4 weeks after operation, 7 cases at 10 weeks after operation, 5 cases at 6 months after operation in group B were found; and there were significant differences in the repair degree of spleen tissue between the two groups at 4 weeks, 10 weeks and 6 months after operation(P < 0.05).There were no significant differences in white blood cell count, red blood cell count and platelet count between the two groups before and after PSE(P>0.05).The incidence of complications in group A(41.38%) was lower than that in group B(71.42%)(P < 0.05). ConclusionsSpiral CT can show the changes of splenic embolization area and spleen volume after PSE, and evaluate the risk of postoperative complications.The percentage of embolization volume less than 50% during PSE is more helpful for postoperative recovery.
2021, 46(5): 661-665.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.026
Abstract:
ObjectiveTo investigate the application value of superb microvascular imaging(SMI), ultrasonic elastography and ultrasound-guided fine needle aspiration biopsy(FNAB) in the diagnosis of thyroid imaging reporting and data system(TI-RADS) 4 thyroid nodules. MethodsSixty-one TI-RADS 4 nodules in 54 patients were detected using SMI, ultrasonic elastography and FNAB before surgery.The results of postoperative pathology was set as the "gold standard", the application value of SMI, ultrasonic elastography, FNAB and combination of the three in the diagnosis of TI-RADS 4 thyroid nodules were analyzed and compared. ResultsAmong the 61 nodules, the results of pathology showed that 24 cases were benign, and 37 cases were malignant.In the diagnosis of thyroid nodules, the sensitivity, specificity and accuracy of SMI were 62.52%, 64.86% and 63.93%, respectively; the sensitivity, specificity and accuracy of ultrasonic elastography were 70.83%, 72.97% and 72.13%, respectively; the sensitivity, specificity and accuracy of FNAB were 83.33%, 83.78% and 83.61%, respectively; and the sensitivity, specificity and accuracy of combination of the three were 91.67%, 91.89% and 91.80%, respectively.The specificity and accuracy of combination of the three in the diagnosis of TI-RADS 4 nodules were higher than those of SMI, ultrasonic elastography and FNAB alone(P < 0.05 and P < 0.01).The differences of the sensitivity between combined diagnosis, and SMI, ultrasound elastography and FNAB alone in the diagnosis of TI-RADS 4 thyroid nodules were not statistically significant(P>0.05). ConclusionsSingle application of SMI, ultrasound elastography and FNAB in the diagnosis or benign or malignant TI-RADS 4 thyroid nodule has certain deficiencies.Combined use of the three can significantly improve the specificity and accuracy of the diagnosis of the nature of TI-RADS 4 thyroid nodules, which has high clinical value.
Investigation on the nutritional status and dietary behavior among urban and rural elderly in Bengbu
2021, 46(5): 666-668, 672.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.027
Abstract:
ObjectiveTo investigate the differences of the nutritional statu and dietary behavior between urban and rural elderly in Bengbu. MethodsThe general information, eating behavior and nutritional status of 1 249 elderly people aged 65 and over stratified by multi-stage randomization from urban and rural area were investigated. ResultsThe malnutrition rate of the elderly in Bengbu was 9.7%, and which in urban area(6.5%) was significantly lower than that in rural area(12.7%)(P < 0.01).The differences of the nutritional status among the elderly with different dietary taste and consumption frequency of vegetable, fruit, fish, poultry, egg, soybean and its product were statistically significant(P < 0.05 to P < 0.01).There was no statistical significance in nutritional status among the elderly with different frequency of consuming milk(P>0.05).The differences of the dietary taste and consumption of vegetable, fruit, fish, poultry, egg, soybean and its product between urban and rural elderly were statistically significant(P < 0.01). ConclusionsThe malnutrition status and dietary behavior of the elderly in urban and rural area are different in Bengbu.
2021, 46(5): 669-672.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.028
Abstract:
ObjectiveTo explore the influencing factors of activity of daily living(ADL) in patients with ischemic stroke. MethodsThe demography, living habits, past medical history and clinical disease data in 511 patients with ischemic stroke were investigated using questionnaire.According to the Barthel index(BI) score, 406 patients with good ADL(BI ≥ 60 points) and 105 patients with poor ADL(BI < 60 points) were divided into two groups.The influencing factors of ADL in patients with ischemic stroke were analyzed. ResultsThe differences of the Oxford-shire community stroke typing, balance ability, cognitive function and National Institute of Health stroke scale(NIHSS) score between two groups were statistically significant(P < 0.05).The results of logistic regression analysis showed that the balance ability and admission NIHSS score were the independent risk factors affecting ADL in patients with ischemic stroke(P < 0.05). ConclusionsThe balance ability and admission NIHSS score are the independent factors affecting ADL in patients with ischemic stroke.
2021, 46(5): 673-678.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.029
Abstract:
ObjectiveTo analyze the evolution process of knowledge atlas of the influencing of socioeconomic status on mental health from 2010 to 2020 based on scientometrics analysis. MethodsThe literatures based on the socioeconomic status and mental health as key words were searched from CNKI database, and the retrieval period was defined as from January 2010 to May 2020.The scientometrics of above literatures were analyzed using Citespace 5.6.R5 software. ResultsFive hundred and eighty-five literatures were selected, and the number of published literatures was increasing year by year.Among them, the socioeconomic status, family socioeconomic status, college students, mental health and social stratification were the topics of high attention.Based on the theory of social stratification, the research gradually extended to the fields of socioeconomic status, social capital, world belief and sense of control, prosocial behavior, self-education expectation and so on.The hot topics of research gradually evolved from socioeconomic status to emotional intelligence. ConclusionsThe research attention in this field is gradually increasing.In the future, various experimental methods, approaches and tools should be adopted to further strengthen and deepen the research in this field.
2021, 46(5): 679-682.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.030
Abstract:
ObjectiveTo explore the mediating role of self-esteem in the relationship between mindfulness and academic engagement among rural order-oriented free medical students. MethodsFour hundred and ninety order-oriented medical students from three medical colleges in Anhui province were investigated using the five-factor mindfulness scale, self-esteem scale and academic input scale. ResultsThe results of correlation analysis showed that there was a positive correlation between mindfulness, self-esteem and academic engagement in pairs(P < 0.01).The results of structural equation model test showed that the self-esteem played a partial mediating role between mindfulness and academic engagement.The fitting indexes of the model were χ2=90.33, df=37, χ2/df=2.377, NFI=0.98, CFI=0.99, IFI=0.99 and RMSEA=0.069.The total effect value of mindfulness on academic motivation was 0.461, the mediating effect value was 0.143, and which accounted for 31.12% of total effect value. ConclusionsThe positive intervention of free medical students contributes to the improvement of self-esteem level, promotion of academic input and improvement of academic level.
2021, 46(5): 683-686, 690.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.031
Abstract:
ObjectiveTo investigate the effects of playing encouragement videos recorded by family members on anxiety status and vital signs of patients with endotracheal intubation in intensive care unit(ICU). MethodsEighty cases of ICU inpatients in a grade A tertiary hospital were divided into the control group(39 cases) and intervention group(41 cases) according to random number table method.The control group received routine ICU care.On the basis of routine ICU care, the intervention group was nursed with the playing encouragement videos recorded by the patients' family members in advance in the morning and evening, and the satisfaction score of patients were recorded at the end of the study.The basic information in two groups was obtained using general information questionnaire, the anxiety status was evaluated by anxiety grading digital score method, and the basic vital signs were recorded by general vital status test sheet.The anxiety score and vital signs between two groups were compared before and after intervention. ResultsThe differences of the anxiety scores in two groups between before intervention and after 1 day of intervention were not statistically significant(P>0.05), and the anxiety scores in intervention group were lower than those in control group after 2, 3 and 4 days of intervention(P < 0.05 to P < 0.01).The differences of the respiratory rate, heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure in two groups between before and after intervention were not statistically significant(P>0.05). ConclusionsPlaying the encouragement video from family members for patients with endotracheal intubation in ICU is an acceptable, safe and feasible intervention measure, which can relieve the anxiety of patients.
2021, 46(5): 687-690.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.032
Abstract:
ObjectiveTo observe the effect of personalized sensory music therapy in postoperative analgesia in children with congenital heart disease. MethodsA total of 60 children with congenital heart disease who were transferred to pediatric intensive care unit after operation were divided into observation group and control group using random number table method(30 cases in each group).The control group was continuously venously pumped with sufentanil citrate after operation, and the observation group was treated with personalized sensory music therapy on the basis of the control group.The face, legs, activity, cry, consolability scale score, monitoring time in intensive care unit, systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation after operation were compared between the two groups. ResultsThe scores of the face, legs, activity, cry, consolability scale and postoperative monitoring time at 12, 24, 48 and 72 hours after operation in observation group were significantly lower than those in control group(P < 0.01).The systolic blood pressure at 12 and 24 hours after operation in observation group was lower than that in control group(P < 0.01 and P < 0.05), the heart rate at 24 and 72 hours after operation in observation group was lower than that in control group(P < 0.01 and P < 0.05), but there were no significant differences in diastolic blood pressure and blood oxygen saturation between the two groups at 12, 24, 48 and 72 hours after operation(P>0.05). ConclusionsThe application of personalized sensory music therapy in postoperative analgesia in children with congenital heart disease can effectively relieve postoperative pain and shorten the monitoring time in pediatric intensive care unit.
2021, 46(5): 691-694.
doi: 10.13898/j.cnki.issn.1000-2200.2021.05.033
Abstract:
ObjectiveTo explore the effects of volunteer care practice on humanistic care ability of junior nurses. MethodsOne hundred and twenty-eight junior nurses were randomly divided into the control group(67 cases) and observation group(61 cases).The control group was trained with routine humanistic care theory, while the observation group was additionally trained with volunteer care practice based on routine theory, once every 2 months, each time for 4 hours, for 4 consecutive times.Two groups were investigated using caring ability inventory(CAI), clinical communication competence scale(CCCS) and nursing career management scale after training. ResultsAfter training, the scores of each dimension among CAI awareness, courage and patience, and total score in observation group were significantly higher than those in control group(P < 0.01), and the score of CCCS in observation group was significantly lower than that in control group(P < 0.01).The score of each dimension among career management promotion fairness, providing career information and total score promoting career development in observation group were higher than those in control group(P < 0.05 to P < 0.01), and the difference of training dimension score was not statistically significant between two groups(P>0.05). ConclusionsThe practice of volunteer care can improve the humanistic care and communication ability of junior nurses, enhance the professional identity, deepen the connotation construction of quality nursing work and improve the quality of nursing service.
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