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2004 Vol. 29, No. 6
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2004, 29(6): 479-481.
Abstract:
Objective: To study expression of Th1/Th2 type cytokines in human peripheral αβT cells activated with CD3 monoclonal antibody(CD3mAb),cultured in neutral and Th2 type polarizing condition.Methods: Peripheral blood mononuclear cells(PBMC) were stimulated with CD3mAb to generate CD3mAb activated T cells(CD3AT);CD3AT cells were cultured in medium with IL-2 as neutral culturing condition,or with IL-4 plus anti-IL-12 neutralizing Ab as Th2 type polarizing condition for three weeks.Fresh isolation PBMC and cultured CD3AT for 7 to 21 days in neutral and Th2 type polarizing condition were stimulated with Phorbo 12-myristate 13-acetate(PMA),ionomycin and monensin.Intracellular cytokines of cell were stained with multicolor fluorescence mAb.The percentage of Th1 and Th2 expressing cell among fresh PBMC or CD3AT were measured by flow cytometry.Results: The percentages of IFN-γ and IL-4 producing T cells among fresh isolation PBMC were 23.6% and 2.4%,respectively.Compared to the neutral condition,in the culture of Th2 polarizing condition for 3 weeks,the percentages of IFN-γ+ producing cells among CD3AT sharply decreased(P<0.001) and that of IL-4 producing T cells had significant increase(P<0.001),and that of IFN-γ+IL-4+αβT cells modestly increased(3.6% to 6.1%).Conclusions: αβT cells in human peripheral blood could be developed as type-2 functional subset in Th2 polarizing condition in vitro.
Objective: To study expression of Th1/Th2 type cytokines in human peripheral αβT cells activated with CD3 monoclonal antibody(CD3mAb),cultured in neutral and Th2 type polarizing condition.Methods: Peripheral blood mononuclear cells(PBMC) were stimulated with CD3mAb to generate CD3mAb activated T cells(CD3AT);CD3AT cells were cultured in medium with IL-2 as neutral culturing condition,or with IL-4 plus anti-IL-12 neutralizing Ab as Th2 type polarizing condition for three weeks.Fresh isolation PBMC and cultured CD3AT for 7 to 21 days in neutral and Th2 type polarizing condition were stimulated with Phorbo 12-myristate 13-acetate(PMA),ionomycin and monensin.Intracellular cytokines of cell were stained with multicolor fluorescence mAb.The percentage of Th1 and Th2 expressing cell among fresh PBMC or CD3AT were measured by flow cytometry.Results: The percentages of IFN-γ and IL-4 producing T cells among fresh isolation PBMC were 23.6% and 2.4%,respectively.Compared to the neutral condition,in the culture of Th2 polarizing condition for 3 weeks,the percentages of IFN-γ+ producing cells among CD3AT sharply decreased(P<0.001) and that of IL-4 producing T cells had significant increase(P<0.001),and that of IFN-γ+IL-4+αβT cells modestly increased(3.6% to 6.1%).Conclusions: αβT cells in human peripheral blood could be developed as type-2 functional subset in Th2 polarizing condition in vitro.
2004, 29(6): 482-485.
Abstract:
Objective: To study the expression of estrogen receptor subtype ERα/β gene mRNA and ERα protein in female breast cancer,and to investigate the expression significance of ER subtype by analyzing the relationship between the expression of ER subtype and the clinic pathologic behavior of breast cancer.Methods: Reverse transcription polymerase chain reaction and immunohistochemistry S-P methods were used to detect the expression of ERα/β gene mRNA and ERα protein in 52 fresh breast cancer samples and 19 fresh breast fibroadenoma samples.Results: The total positive rate of ERβ mRNA was 51.9% in breast cancer,which was significantly higher than that in breast fibroadenoma(P<0.05).The positive rate of ERα mRNA alone in breast fibroadenoma was 63.2%,which was significantly higher than that in breast cancer(P<0.05).The coexpression rate of ERα and ERβ mRNA in breast cancer was 51.9%,higher than that(15.8%) in breast fibroadenoma(P<0.05).The phenotype of coexpression ERα and ERβ in breast cancer was associated with positive lymph node(P<0.05),and there was a trend toward higher grade.There was no significant difference between the positive rate of ERα protein in breast cancer and breast fibroadenoma.Conclusions: The coexpression of ERαand ERβ in breast cancer may be a poor prognostic factor for patients with breast cancer.
Objective: To study the expression of estrogen receptor subtype ERα/β gene mRNA and ERα protein in female breast cancer,and to investigate the expression significance of ER subtype by analyzing the relationship between the expression of ER subtype and the clinic pathologic behavior of breast cancer.Methods: Reverse transcription polymerase chain reaction and immunohistochemistry S-P methods were used to detect the expression of ERα/β gene mRNA and ERα protein in 52 fresh breast cancer samples and 19 fresh breast fibroadenoma samples.Results: The total positive rate of ERβ mRNA was 51.9% in breast cancer,which was significantly higher than that in breast fibroadenoma(P<0.05).The positive rate of ERα mRNA alone in breast fibroadenoma was 63.2%,which was significantly higher than that in breast cancer(P<0.05).The coexpression rate of ERα and ERβ mRNA in breast cancer was 51.9%,higher than that(15.8%) in breast fibroadenoma(P<0.05).The phenotype of coexpression ERα and ERβ in breast cancer was associated with positive lymph node(P<0.05),and there was a trend toward higher grade.There was no significant difference between the positive rate of ERα protein in breast cancer and breast fibroadenoma.Conclusions: The coexpression of ERαand ERβ in breast cancer may be a poor prognostic factor for patients with breast cancer.
2004, 29(6): 485-486.
Abstract:
Objective: To study the effect of arsenic trioxide on induction of apoptosis of melanoma A375 cell line.Methods: Early apoptosis rate and late apoptosis rate in A375 cells were analysed by flow cytometry.Results: After pretreated with arsenic trioxide of 5 μmol/L,10 μmol/L,and 20 μmol/L,the early apoptosis rate in A375 cells were 9.75%,50.9%,and 43.7%,respectively.The late apoptosis rate in A375 cells were 2.10%,4.61%,and 11.2%,respectively.The totle apoptosis rate were 11.85%,55.51%,and 54.9%,respectively.Conclusions: The early and the late apoptosis rate in A375 cells were induced by arsenic trioxide.
Objective: To study the effect of arsenic trioxide on induction of apoptosis of melanoma A375 cell line.Methods: Early apoptosis rate and late apoptosis rate in A375 cells were analysed by flow cytometry.Results: After pretreated with arsenic trioxide of 5 μmol/L,10 μmol/L,and 20 μmol/L,the early apoptosis rate in A375 cells were 9.75%,50.9%,and 43.7%,respectively.The late apoptosis rate in A375 cells were 2.10%,4.61%,and 11.2%,respectively.The totle apoptosis rate were 11.85%,55.51%,and 54.9%,respectively.Conclusions: The early and the late apoptosis rate in A375 cells were induced by arsenic trioxide.
2004, 29(6): 489-491.
Abstract:
Objective: To observe the presentation and prognosis of acute poststreptococcal glomerulonephritis with nephrotic syndrome(APSGN with NS).Methods: The clinical data of a homogeneous group of 26 patients hospitalized and followed-up for APSGN with NS in our department(1993 to 2001) were analyzed.Results: Edema resolved within 5 to 35 days,proteinuria disappeared within 2 weeks to 3 months,BP returned to normal within 7 to 28 days,and hematusia disappeared within 8 days to 19 months.All the cases were cured and no one died.Conclusions: APSGN with NS is associated with severe clinical presentation.Gross hematuria and proteinuria exist continuously for a long period.Long term follow-up shows that the prognosis of majority of them is good.
Objective: To observe the presentation and prognosis of acute poststreptococcal glomerulonephritis with nephrotic syndrome(APSGN with NS).Methods: The clinical data of a homogeneous group of 26 patients hospitalized and followed-up for APSGN with NS in our department(1993 to 2001) were analyzed.Results: Edema resolved within 5 to 35 days,proteinuria disappeared within 2 weeks to 3 months,BP returned to normal within 7 to 28 days,and hematusia disappeared within 8 days to 19 months.All the cases were cured and no one died.Conclusions: APSGN with NS is associated with severe clinical presentation.Gross hematuria and proteinuria exist continuously for a long period.Long term follow-up shows that the prognosis of majority of them is good.
2004, 29(6): 491-492.
Abstract:
Objective: To explore the feasibility and significance of extended lymph node dissection in treating patients with the carcinoma of the head of the pancreas and periampullary adenocarcinoma and to make out the appropriate indications for extended lymph node dissection.Methods: The clinical data of 16 cases of carcinoma of the head of the pancreas and periampullary adenocarcinoma subjected to extended lymph node dissection from October 2000 to October 2003 were analyzed.Results: Six of 16 cases were lymph node positive(37.5%) and the positive rate in cases with the tumor of the head of the pancreas and periampullary adenocarcinoma was not obviously different in the diameter,locating the head of the pancreas(P=0.588-P=0.511).The incidence of complications was not noticeably increased and there was no operative mortality.Conclusions: Extended lymph node dissection in treating patients with carcinoma of the head of the pancreas and periampullary adenocarcinoma appears to be relatively safe,feasible and effective.
Objective: To explore the feasibility and significance of extended lymph node dissection in treating patients with the carcinoma of the head of the pancreas and periampullary adenocarcinoma and to make out the appropriate indications for extended lymph node dissection.Methods: The clinical data of 16 cases of carcinoma of the head of the pancreas and periampullary adenocarcinoma subjected to extended lymph node dissection from October 2000 to October 2003 were analyzed.Results: Six of 16 cases were lymph node positive(37.5%) and the positive rate in cases with the tumor of the head of the pancreas and periampullary adenocarcinoma was not obviously different in the diameter,locating the head of the pancreas(P=0.588-P=0.511).The incidence of complications was not noticeably increased and there was no operative mortality.Conclusions: Extended lymph node dissection in treating patients with carcinoma of the head of the pancreas and periampullary adenocarcinoma appears to be relatively safe,feasible and effective.
2004, 29(6): 493-494.
Abstract:
Objective: To observe the Gram-negative bacterial resistance in patients in Intensive Care Unit(ICU) and to discuss how to treat infections caused by these resistant strains.Methods: The minimal inhibitory concentrations of 10 antibiotics against 160 strains of Gram-negative bacilli isolated from ICU patients were determined by E test.Results: The resistance rates to imipenem,cefepime and sulbactam-cefoperazone were the lowest,being 11.3%、18.8% and 20.6%,respectively.Forty-one ESBLs-producing strains were susceptible to imipenem,cefepime and sulbactam-cefoperazone,with a susceptible rate of 90.2%,82.9% and 80.5%,respectively.Conclusions: Imipenem is the most active agent against severe systemic infections caused by ESBLs-producing strains,while β-lactam/β-lactamase inhibitors are also active against most strains.
Objective: To observe the Gram-negative bacterial resistance in patients in Intensive Care Unit(ICU) and to discuss how to treat infections caused by these resistant strains.Methods: The minimal inhibitory concentrations of 10 antibiotics against 160 strains of Gram-negative bacilli isolated from ICU patients were determined by E test.Results: The resistance rates to imipenem,cefepime and sulbactam-cefoperazone were the lowest,being 11.3%、18.8% and 20.6%,respectively.Forty-one ESBLs-producing strains were susceptible to imipenem,cefepime and sulbactam-cefoperazone,with a susceptible rate of 90.2%,82.9% and 80.5%,respectively.Conclusions: Imipenem is the most active agent against severe systemic infections caused by ESBLs-producing strains,while β-lactam/β-lactamase inhibitors are also active against most strains.
2004, 29(6): 495-497.
Abstract:
Objective: To summarize the experience in the application of mechanical ventilation and airway management after the open heart surgery for congenital heart disease.Methods: SIMV and PEEP and PSV model was performed after the operation and SpO2,ETCO2、BP and blood gas were monitored.Results: Seventeen cases developed dyspnea after the removal of the mechanical ventilation,and 5 of them had to resume using the mechanical ventilation.And the dyspnea in the other 12 cases was relieved by continuous positive pressure ventilation(CPAP).The intratracheal secretion culture and smear test were carried out in 52 cases were.The results were positive in 19 cases,8 cases had Klebsiella pneumonia and 11 cases fungi.Fifteen cases had pulmonary atelectasis and 3 cases pneumethorax.Conclusions: The mechanical ventilation is essential for the patients with congenital heart disease after the operation,but the mechanical ventilation should be removed as early as possible.To the patients presenting dyspnea after the removal of the mechanical ventilation,CPAP should be restored immediately.Antibiotics should be applied to the patients with pneumonia according to the results of the intratracheal secretion culture and smear test.
Objective: To summarize the experience in the application of mechanical ventilation and airway management after the open heart surgery for congenital heart disease.Methods: SIMV and PEEP and PSV model was performed after the operation and SpO2,ETCO2、BP and blood gas were monitored.Results: Seventeen cases developed dyspnea after the removal of the mechanical ventilation,and 5 of them had to resume using the mechanical ventilation.And the dyspnea in the other 12 cases was relieved by continuous positive pressure ventilation(CPAP).The intratracheal secretion culture and smear test were carried out in 52 cases were.The results were positive in 19 cases,8 cases had Klebsiella pneumonia and 11 cases fungi.Fifteen cases had pulmonary atelectasis and 3 cases pneumethorax.Conclusions: The mechanical ventilation is essential for the patients with congenital heart disease after the operation,but the mechanical ventilation should be removed as early as possible.To the patients presenting dyspnea after the removal of the mechanical ventilation,CPAP should be restored immediately.Antibiotics should be applied to the patients with pneumonia according to the results of the intratracheal secretion culture and smear test.
2004, 29(6): 497-498.
Abstract:
Objective: To explore the efficacy of different doses' of IVIG in treatment of Kawasaki disease.Methods: The data of 41 cases of Kawasaki disease admitted to our hospital from 1995 to 2003 were reviewed.Results: Seventeen cases were treated with IVIG 1g/kg(400-500 mg·kg-1·d-1,for 2-3 days).22 cases with IVIG 2 g/kg(400 mg·kg-1·d-1 for 5 days).There was no obvious difference between the two groups(P=1.000) in the lasting time of fever,blood white cell count,and coronary artery dilation(CAD).Conclusions: The efficacy of two different dose of IVIG is almost equal in treatment of Kawasaki disease.We suggest that 1 g/kg IVIG be used to save the drug resource and reduce the cost.
Objective: To explore the efficacy of different doses' of IVIG in treatment of Kawasaki disease.Methods: The data of 41 cases of Kawasaki disease admitted to our hospital from 1995 to 2003 were reviewed.Results: Seventeen cases were treated with IVIG 1g/kg(400-500 mg·kg-1·d-1,for 2-3 days).22 cases with IVIG 2 g/kg(400 mg·kg-1·d-1 for 5 days).There was no obvious difference between the two groups(P=1.000) in the lasting time of fever,blood white cell count,and coronary artery dilation(CAD).Conclusions: The efficacy of two different dose of IVIG is almost equal in treatment of Kawasaki disease.We suggest that 1 g/kg IVIG be used to save the drug resource and reduce the cost.
2004, 29(6): 499-500.
Abstract:
Objective: To explore the surgery opportunity and prevention of complications for penetrating injury of cornea with traumatic cataract.Methods: Forty cases performed lacerated corneal suture and extracapsular cataract extraction with intraocular lens implantation from 1998 to 2002 in our hospital were analyzed,and the prevention and treatment of the complications were reviewed.Results: All the cases were followed up for 2 to 24 months.The postoperative vision was 0.6 to 1.0 in 5 eyes(12.5%),0.3 to 0.5 in 16 eyes(40%),0.05 to 0.2 in 17 eyes(42.5%),and below 0.05 in 2 eyes(5%).The main postoperative complications were uveitis and after-cataract.Conclusions: Proper time of operation and management of complications can lead to satisfactory therapeutic result for the patients with penetrating injury of cornea with traumatic cataract.
Objective: To explore the surgery opportunity and prevention of complications for penetrating injury of cornea with traumatic cataract.Methods: Forty cases performed lacerated corneal suture and extracapsular cataract extraction with intraocular lens implantation from 1998 to 2002 in our hospital were analyzed,and the prevention and treatment of the complications were reviewed.Results: All the cases were followed up for 2 to 24 months.The postoperative vision was 0.6 to 1.0 in 5 eyes(12.5%),0.3 to 0.5 in 16 eyes(40%),0.05 to 0.2 in 17 eyes(42.5%),and below 0.05 in 2 eyes(5%).The main postoperative complications were uveitis and after-cataract.Conclusions: Proper time of operation and management of complications can lead to satisfactory therapeutic result for the patients with penetrating injury of cornea with traumatic cataract.
2004, 29(6): 501-503.
Abstract:
Objective: To study the influence of obesity on insulin(INS) and C-peptide(CP) level of elderly patients with Type 2 diabetes.Methods: Sixty-one cases of type 2 diabetics were included in the observation group and 58 healthy people acted as controls.All the subjects underwent 75 g oral glucose tolerance test(OGTT),insulin release test,CP release test,and the insulin sensitivity index(ISI) was calculated.Results: The 1 h level of INS of the obese cases in the observation group was lower than those of the control group(P<0.05),INS and CP responses during the OGTT were similar in obese subjects of the two groups.The 1 h,2 h levels of INS,and 1 h,2 h,3 h levels of CP after sugar test were reduced in non-obese subjects of the two groups(P<0.05 to P< 0.01).The levels of INS,CP of all the points during INS and CP releasing tests were higher in the obese subjects of the two groups than those in the non-obese subjects(P<0.05 to P<0.01),but ISI reduced significantly in the non-obese subjects,compared with the obese subjects(P<0.01).Conclusions: Obese elderly patients with type 2 diabetics have adequate circulating insulin level,but marked insulin resistance(IR).Non-obese elderly patients with type 2 diabetic have a profound impairment in glucose-induced IR but mild resistance.
Objective: To study the influence of obesity on insulin(INS) and C-peptide(CP) level of elderly patients with Type 2 diabetes.Methods: Sixty-one cases of type 2 diabetics were included in the observation group and 58 healthy people acted as controls.All the subjects underwent 75 g oral glucose tolerance test(OGTT),insulin release test,CP release test,and the insulin sensitivity index(ISI) was calculated.Results: The 1 h level of INS of the obese cases in the observation group was lower than those of the control group(P<0.05),INS and CP responses during the OGTT were similar in obese subjects of the two groups.The 1 h,2 h levels of INS,and 1 h,2 h,3 h levels of CP after sugar test were reduced in non-obese subjects of the two groups(P<0.05 to P< 0.01).The levels of INS,CP of all the points during INS and CP releasing tests were higher in the obese subjects of the two groups than those in the non-obese subjects(P<0.05 to P<0.01),but ISI reduced significantly in the non-obese subjects,compared with the obese subjects(P<0.01).Conclusions: Obese elderly patients with type 2 diabetics have adequate circulating insulin level,but marked insulin resistance(IR).Non-obese elderly patients with type 2 diabetic have a profound impairment in glucose-induced IR but mild resistance.
2004, 29(6): 504-506.
Abstract:
Objective: To decrease the complications and death rate of pregnant women and their infant whose glucose metabolism is anomalous during gestation period.Methods: The clinical data of twenty pregnant women suffering from abnormal glucose metabolism in our hospital from 1995 to 2003 were analyzed retrospectively and the results were compared with that of normal pregnant women.Results: Women with abnormal glucose metabolism in the gestation period had obviously higher death rate of pregnant women and their infant and infants than other pregnant women(P=0.041 5-P=0.0013).Conclusions: Enhancing the examination and treatment of pregnant women whose glucose metabolism is anomalous during pregnant and labor period,and choosing appropriate laboring methods can decrease the incidence of complications of anomalous glucose metabolism and death rate of pregnant women and their infant and make the diabetes diagnosed and treated as early as possible.
Objective: To decrease the complications and death rate of pregnant women and their infant whose glucose metabolism is anomalous during gestation period.Methods: The clinical data of twenty pregnant women suffering from abnormal glucose metabolism in our hospital from 1995 to 2003 were analyzed retrospectively and the results were compared with that of normal pregnant women.Results: Women with abnormal glucose metabolism in the gestation period had obviously higher death rate of pregnant women and their infant and infants than other pregnant women(P=0.041 5-P=0.0013).Conclusions: Enhancing the examination and treatment of pregnant women whose glucose metabolism is anomalous during pregnant and labor period,and choosing appropriate laboring methods can decrease the incidence of complications of anomalous glucose metabolism and death rate of pregnant women and their infant and make the diabetes diagnosed and treated as early as possible.
2004, 29(6): 506-507.
Abstract:
Objective: To investigate the importance of calcanceal traction before operation of Pilon fracture and its indications.Methods: Thirty-two cases(34 limbs) of Pilon fracture were treated.According to Rüedi-Allgower classification,6 cases were classified as typeⅠ,21 cases typeⅡ,and 5 cases typeⅢ.Six cases were treated with anipalative reduction and external fixation by cast,4 cases with calcanceal traction and spliats fixation,17 cases with anatominal plate of distal tibia and 5 cases with limited open reduction and internal screw fixation combined with unilateral external fixation.Two cases received auto-ilium transplant and 3 cases artificial bone transplant.Results: All the cases were followed up for 4 months to 3.5 years.The results were excellent in 23 cases,good in 5 and poor in 4.Conclusions: proper measures should be taken according to the types of Pilon fracture.
Objective: To investigate the importance of calcanceal traction before operation of Pilon fracture and its indications.Methods: Thirty-two cases(34 limbs) of Pilon fracture were treated.According to Rüedi-Allgower classification,6 cases were classified as typeⅠ,21 cases typeⅡ,and 5 cases typeⅢ.Six cases were treated with anipalative reduction and external fixation by cast,4 cases with calcanceal traction and spliats fixation,17 cases with anatominal plate of distal tibia and 5 cases with limited open reduction and internal screw fixation combined with unilateral external fixation.Two cases received auto-ilium transplant and 3 cases artificial bone transplant.Results: All the cases were followed up for 4 months to 3.5 years.The results were excellent in 23 cases,good in 5 and poor in 4.Conclusions: proper measures should be taken according to the types of Pilon fracture.
2004, 29(6): 508-510.
Abstract:
Objective: To compare the effect of epidural block and nitrous oxide in analgesic labor.Methods: Epidural block group were injected 0.2% ropivecaine 9 ml and fentanyl compound 1 ml in to the epidurale cavum and 5 ml mixture was added according to the maternity conditions.Nitrous oxide group 50% nitrous oxide and 50% oxygen.Results: The anesthetic effect differed significantly during the active period and the second labor stage(P<0.01).The time of second labor stage in the epidural block group was longer than that in nitrous oxide group(P<0.05).There was no significant difference in the first labor stage,the third labor stage,the mode of delivery,bleeding volumn,fetal distress and neonatal asphyxia(P>0.05).There was no significant difference in the oxygen saturation and diastolic pressure after anesthesia.The nitrous oxide group had higher respairatory rate,heart rate and systolic pressure than the epidural block group(P<0.05 to P<0.01).Conclusions: The anethestic effect of epidural block is much better than that of nitrous oxcide.Patients using epidural block must be monitored by a technical analgesist and the second birth process has the to extend.The anethetic effect of nitrous oxide is a bit weak,but the patients do not need a technical analgesist.Nitrous oxide is better accepted by the patient and the hospital at the basic level. Back
Objective: To compare the effect of epidural block and nitrous oxide in analgesic labor.Methods: Epidural block group were injected 0.2% ropivecaine 9 ml and fentanyl compound 1 ml in to the epidurale cavum and 5 ml mixture was added according to the maternity conditions.Nitrous oxide group 50% nitrous oxide and 50% oxygen.Results: The anesthetic effect differed significantly during the active period and the second labor stage(P<0.01).The time of second labor stage in the epidural block group was longer than that in nitrous oxide group(P<0.05).There was no significant difference in the first labor stage,the third labor stage,the mode of delivery,bleeding volumn,fetal distress and neonatal asphyxia(P>0.05).There was no significant difference in the oxygen saturation and diastolic pressure after anesthesia.The nitrous oxide group had higher respairatory rate,heart rate and systolic pressure than the epidural block group(P<0.05 to P<0.01).Conclusions: The anethestic effect of epidural block is much better than that of nitrous oxcide.Patients using epidural block must be monitored by a technical analgesist and the second birth process has the to extend.The anethetic effect of nitrous oxide is a bit weak,but the patients do not need a technical analgesist.Nitrous oxide is better accepted by the patient and the hospital at the basic level. Back
2004, 29(6): 510-511.
Abstract:
Objective: To observe the effect of sodium ferulate in treatment of chronic glomerulonephritis.Methods: Fifty-six cases of chronic glomerulonephritis were randomly divided into treatment group(30 cases) and control group(26 cases).The treatment group were administered sodium ferulate and the controls received guttae intravenously and vitamin B 6.The curative effect was evaluated after 21 days.Results: There was significant difference between the two groups in the time of symptom disappearing,the plasma contrast viscosity,24 h urine protein quantization and creatinine clearance rate(Ccr) and serum creatinine(Scr)(P<0.05 to P< 0.01).Conclusions: Sodium ferulate can improve the blood hypercoagulation state; reduce the content of urine protein,lower the blood pressure and minimize the injury of vascular endothelium.It may protect the renal function to a certain extent and improve the prognosis of chronic glomerulonephritis.
Objective: To observe the effect of sodium ferulate in treatment of chronic glomerulonephritis.Methods: Fifty-six cases of chronic glomerulonephritis were randomly divided into treatment group(30 cases) and control group(26 cases).The treatment group were administered sodium ferulate and the controls received guttae intravenously and vitamin B 6.The curative effect was evaluated after 21 days.Results: There was significant difference between the two groups in the time of symptom disappearing,the plasma contrast viscosity,24 h urine protein quantization and creatinine clearance rate(Ccr) and serum creatinine(Scr)(P<0.05 to P< 0.01).Conclusions: Sodium ferulate can improve the blood hypercoagulation state; reduce the content of urine protein,lower the blood pressure and minimize the injury of vascular endothelium.It may protect the renal function to a certain extent and improve the prognosis of chronic glomerulonephritis.
2004, 29(6): 512-513.
Abstract:
Objective: To evaluate the surgical operation for treatment of Chiari malformation associated with hydromyelia. Methods: Thirteen patients with Chiari malformation associated with hydromyelia, which were diagnosed with magnetic resonance imaging(MRI),and treated by surgical operation were retrospectively studied. Results: The mean follow-up periods were 2.1 years. The degree of reduction of the volume of syrinx cavity on sagittal MRI was significant after operation. Conclusions: Cisterna magna reconstruction is a safe and effective way for the treatment of Chiari malformation associated with hydromyelia.
Objective: To evaluate the surgical operation for treatment of Chiari malformation associated with hydromyelia. Methods: Thirteen patients with Chiari malformation associated with hydromyelia, which were diagnosed with magnetic resonance imaging(MRI),and treated by surgical operation were retrospectively studied. Results: The mean follow-up periods were 2.1 years. The degree of reduction of the volume of syrinx cavity on sagittal MRI was significant after operation. Conclusions: Cisterna magna reconstruction is a safe and effective way for the treatment of Chiari malformation associated with hydromyelia.
2004, 29(6): 514-515.
Abstract:
Objective: To discuss the treatment for incidental renal cell carcinoma.Methods: Twenty-two patients with incidental renal cell carcinoma underwent the nephron-sparing surgery.Among them,17 patients had normal opposite kidney,2 patients had damaged or potential disfunctional opposite kidney,1 patient had congenital isolated kidney,1 patient had tumor in his transplanted kidney and 1 patient had von hipple-Lindau's syndrome.Results: All the patients were followed up for 6 to 62 months.Only 1 patient had a relapse.Conclusions: Nephron-sparing surgery is an effective procedure for treatment of incidental renal cell carcinoma.
Objective: To discuss the treatment for incidental renal cell carcinoma.Methods: Twenty-two patients with incidental renal cell carcinoma underwent the nephron-sparing surgery.Among them,17 patients had normal opposite kidney,2 patients had damaged or potential disfunctional opposite kidney,1 patient had congenital isolated kidney,1 patient had tumor in his transplanted kidney and 1 patient had von hipple-Lindau's syndrome.Results: All the patients were followed up for 6 to 62 months.Only 1 patient had a relapse.Conclusions: Nephron-sparing surgery is an effective procedure for treatment of incidental renal cell carcinoma.
2004, 29(6): 516-517.
Abstract:
Objective: To evaluate the efficacy of high dose immunoglobulin in treatment of severe viral encephalitis in children.Methods: Thirty-eight children were divided into study group(n=16) treated with intravenous high dose immunoglobulin and control group(n=22).The clinical symptoms,physical signs and the time of hospital stay were observed and compared.Results: It took less time for the study group to bring down a fever,stop spasm and regain consciousness than it did for the control group(P<0.05 to P<0.01),and no difference was found in the time of hospital stay between the two groups(P>0.05).Conclusions: Intravenous high dose immunoglobulin can relieve brain tissue damage and is effective in treating severe viral encephalitis of children.
Objective: To evaluate the efficacy of high dose immunoglobulin in treatment of severe viral encephalitis in children.Methods: Thirty-eight children were divided into study group(n=16) treated with intravenous high dose immunoglobulin and control group(n=22).The clinical symptoms,physical signs and the time of hospital stay were observed and compared.Results: It took less time for the study group to bring down a fever,stop spasm and regain consciousness than it did for the control group(P<0.05 to P<0.01),and no difference was found in the time of hospital stay between the two groups(P>0.05).Conclusions: Intravenous high dose immunoglobulin can relieve brain tissue damage and is effective in treating severe viral encephalitis of children.
2004, 29(6): 518-519.
Abstract:
Objective: To evaluate the surgical management of ureteropelvic junction(UPJ) obstruction.Methods: Thirty-two cases of congenital UPJ obstruction were treated by Anderson-Hynes pyeloplasty.Double-J stents were used as internal stands and drainage.Results: All the obstructions were successfully relieved,hydronephrosis was greatly improved and no complications such as urinary infection,leakage of urine or restricture were noted at follow-up.Conclusions: Anderson-Hynes pyeloplasty is an efficient treatment for congenital obstruction of UPJ,and the use of double-J stent as internal stand and drainage can help recovery of kidney function,reduce the chance of UPJ restriction,and raise the rate of success.
Objective: To evaluate the surgical management of ureteropelvic junction(UPJ) obstruction.Methods: Thirty-two cases of congenital UPJ obstruction were treated by Anderson-Hynes pyeloplasty.Double-J stents were used as internal stands and drainage.Results: All the obstructions were successfully relieved,hydronephrosis was greatly improved and no complications such as urinary infection,leakage of urine or restricture were noted at follow-up.Conclusions: Anderson-Hynes pyeloplasty is an efficient treatment for congenital obstruction of UPJ,and the use of double-J stent as internal stand and drainage can help recovery of kidney function,reduce the chance of UPJ restriction,and raise the rate of success.
2004, 29(6): 520-522.
Abstract:
Objective: To investigate the efficacy of different blood purification techniques on acute renal failure.Methods: Twenty-five patients with severe acute renal failure,11 of whom suffered from mutliple organ dysfuction syndrome,were treated by intermitten hemodialysis(IHD),continuous hemodiafiltration(CVVHDF) and plasma exchange(PE).The predialysis and postdialysis serum urea nitrogen,creatinine and bilirubin were measured.The results were analysed and compared.Results: The total mortality was 24.0%.IHD was more effective in eliminating serum urea nitrogen and creatinine than CVVHDF or PE,while PE had better effect in eliminating bilirubin than CVVHDF or IHD.Conclusions: The combined therapy of IHD,CVVHDF and PE may reduce mortality of acute renal failure.
Objective: To investigate the efficacy of different blood purification techniques on acute renal failure.Methods: Twenty-five patients with severe acute renal failure,11 of whom suffered from mutliple organ dysfuction syndrome,were treated by intermitten hemodialysis(IHD),continuous hemodiafiltration(CVVHDF) and plasma exchange(PE).The predialysis and postdialysis serum urea nitrogen,creatinine and bilirubin were measured.The results were analysed and compared.Results: The total mortality was 24.0%.IHD was more effective in eliminating serum urea nitrogen and creatinine than CVVHDF or PE,while PE had better effect in eliminating bilirubin than CVVHDF or IHD.Conclusions: The combined therapy of IHD,CVVHDF and PE may reduce mortality of acute renal failure.
2004, 29(6): 524-526.
Abstract:
Objective: To study the procedure,effect and safety of treating esophageal cardiac and anastomotic mouth stricture by dilation and implantation of stents under endoscopy.Methods: Thirty-three cases of esophageal cardiac and anastomotic mouth stricture were treated by inserting a lead through the stricture part under endoscopy and X-ray fluoroscopy,then a Savary-Gilliard dilator was used to dilate the stricture part slowly to 10-15 mm.For those who had malignant stricture,post-operative stricture or recurrence of carcinoma,stents were implanted in addition to ditation.Results: Eighteen cases were treated by dilation only,17 of whom received the therapy for one or two times;and 1 of whom four times;15 cases were treated by dilation,as well as implantation of stents.All were successful for once.After operation,the stricture state decreased Ⅱ degreses by Stooler standard in 28 cases,I degree in 4 cases and did not decrease in 1 case.No severe pain,massive haemoorrhage or perfortion occurred.Conclusions: It is effective and safe to treat esophageal cardiac and anastomotic mouth stricture by dilation and implatation of stents under endoscopy.In the operation,we must make sure that the lead goes through the stricture part and is properly fastened;the stricture part is expanded effectively and the stent implanted in place.
Objective: To study the procedure,effect and safety of treating esophageal cardiac and anastomotic mouth stricture by dilation and implantation of stents under endoscopy.Methods: Thirty-three cases of esophageal cardiac and anastomotic mouth stricture were treated by inserting a lead through the stricture part under endoscopy and X-ray fluoroscopy,then a Savary-Gilliard dilator was used to dilate the stricture part slowly to 10-15 mm.For those who had malignant stricture,post-operative stricture or recurrence of carcinoma,stents were implanted in addition to ditation.Results: Eighteen cases were treated by dilation only,17 of whom received the therapy for one or two times;and 1 of whom four times;15 cases were treated by dilation,as well as implantation of stents.All were successful for once.After operation,the stricture state decreased Ⅱ degreses by Stooler standard in 28 cases,I degree in 4 cases and did not decrease in 1 case.No severe pain,massive haemoorrhage or perfortion occurred.Conclusions: It is effective and safe to treat esophageal cardiac and anastomotic mouth stricture by dilation and implatation of stents under endoscopy.In the operation,we must make sure that the lead goes through the stricture part and is properly fastened;the stricture part is expanded effectively and the stent implanted in place.
2004, 29(6): 560-561.
Abstract:
Objective: To evaluate ultrasonography in the detection of atherosclerotic lesions of the carotid artery in hypertensive subjects.Methods: The carotid artery hypertensive patients of 158 and 122 controls was examined by ultrasonography.The bores,intra-medial thickness(IMT),PSV,EDV and RI of the carotid artery were measured and the atherosclerotic plaques were observed by gray-scale imaging,color and spectral Doppler respectively.Results: There was significant difference between the group of hypertension and the control in IMT,bores and RI(P<0.05 to P<0.001).The incidence of plaques in the group of hypertension was higher than that in the group of control(P<0.005).Conclusions: Ultrasonogrphy plays an important role in the early diagnosis of atherosclerosis,and follow-up of artery lesions change,for patients with hypertension.
Objective: To evaluate ultrasonography in the detection of atherosclerotic lesions of the carotid artery in hypertensive subjects.Methods: The carotid artery hypertensive patients of 158 and 122 controls was examined by ultrasonography.The bores,intra-medial thickness(IMT),PSV,EDV and RI of the carotid artery were measured and the atherosclerotic plaques were observed by gray-scale imaging,color and spectral Doppler respectively.Results: There was significant difference between the group of hypertension and the control in IMT,bores and RI(P<0.05 to P<0.001).The incidence of plaques in the group of hypertension was higher than that in the group of control(P<0.005).Conclusions: Ultrasonogrphy plays an important role in the early diagnosis of atherosclerosis,and follow-up of artery lesions change,for patients with hypertension.
2004, 29(6): 562-564.
Abstract:
Objective: To evaluate the clinical value of sonographic diagnosis for gastrointestinal perforation.Methods: The manifestation of the sonography and the radiology of 32 patients operated on for gastrointestinal perforation was compared retrospectively.Results: The sonographic findings of the gastrointestinal perforation included free air,fluid and abnormal echo mass in the abdomen and the sensitivity rates were 84%(27/32),93%(30/32) and 68%(22/32),respectively.The diagnostic basis of gastrointestinal perforation by X-ray is free subdiaphragm air,with a sensitivity of 75%(24/32),but the mass and fluid were unable to be displayed.Conclusions: Detection of free air,fluid and irregular shaped mass in the abdomen by sonography can provide reliable attestation to the clinical diagnosis of gastrointestinal perforation.
Objective: To evaluate the clinical value of sonographic diagnosis for gastrointestinal perforation.Methods: The manifestation of the sonography and the radiology of 32 patients operated on for gastrointestinal perforation was compared retrospectively.Results: The sonographic findings of the gastrointestinal perforation included free air,fluid and abnormal echo mass in the abdomen and the sensitivity rates were 84%(27/32),93%(30/32) and 68%(22/32),respectively.The diagnostic basis of gastrointestinal perforation by X-ray is free subdiaphragm air,with a sensitivity of 75%(24/32),but the mass and fluid were unable to be displayed.Conclusions: Detection of free air,fluid and irregular shaped mass in the abdomen by sonography can provide reliable attestation to the clinical diagnosis of gastrointestinal perforation.
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