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2007 Vol. 32, No. 5
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2007, 32(5): 505-507.
Abstract:
Objective: To breed and identify aquaporin-3 (AQP-3) gene knock-out mice. Methods: Heterozygote mice were bred and reproduced. Wild genotype, heterozygote genotype and homozygote genotype would appear in the offsprings of parents. Genome DNA extracted from the murine tails was subjected to PCR for genotype identification. Male homozygote mice were selected to mate with the female heterozygote mice to acquire homozygote baby mice according to Mendel law. Results: The breeding and reproducing were successful and more heterozygote genotype mice were reproduced. Conclusions: Appropriate methods of breeding, reproducing and identifying are effective ways for acquiring AQP-3 gene knock-out mice from heterozygote mice.
Objective: To breed and identify aquaporin-3 (AQP-3) gene knock-out mice. Methods: Heterozygote mice were bred and reproduced. Wild genotype, heterozygote genotype and homozygote genotype would appear in the offsprings of parents. Genome DNA extracted from the murine tails was subjected to PCR for genotype identification. Male homozygote mice were selected to mate with the female heterozygote mice to acquire homozygote baby mice according to Mendel law. Results: The breeding and reproducing were successful and more heterozygote genotype mice were reproduced. Conclusions: Appropriate methods of breeding, reproducing and identifying are effective ways for acquiring AQP-3 gene knock-out mice from heterozygote mice.
2007, 32(5): 508-510.
Abstract:
Objective: To investigate the effects of three-dimensional culture of bone marrow stromal cells for the repair of articular cartilage defects. Methods: Twenty-four rabbits aged between 4 and 6 months were selected randomly for cells harvest. These cells were cultured for three generations. Then the cells were used to make 1×108/ml suspend, and transplanted into collagenⅠsponge. Two weeks later, the cells were transplanted into self-cartilage with 3.5 mm diameter, and observed in Month One, Two and Three. Results: Bone marrow stromal cells can grow well in collagen Ⅰsponge. The cartilage forms and repairs the chondral defects. The repair organism featured fibro-cartilage in Month One. It showed characteristics of hyaline cartilage in Month Two and biologic functions in Month Three. Conclusions: The engineered cartilage can repair chondral defects and the hyaline cartilage is involved in repair organism.
Objective: To investigate the effects of three-dimensional culture of bone marrow stromal cells for the repair of articular cartilage defects. Methods: Twenty-four rabbits aged between 4 and 6 months were selected randomly for cells harvest. These cells were cultured for three generations. Then the cells were used to make 1×108/ml suspend, and transplanted into collagenⅠsponge. Two weeks later, the cells were transplanted into self-cartilage with 3.5 mm diameter, and observed in Month One, Two and Three. Results: Bone marrow stromal cells can grow well in collagen Ⅰsponge. The cartilage forms and repairs the chondral defects. The repair organism featured fibro-cartilage in Month One. It showed characteristics of hyaline cartilage in Month Two and biologic functions in Month Three. Conclusions: The engineered cartilage can repair chondral defects and the hyaline cartilage is involved in repair organism.
2007, 32(5): 511-514.
Abstract:
Objective: To explore the apoptosis of endothelial cells after acute deep venous thrombosis in rabbit and its significanse in the pathological processes. Methods: Fifty-five adult rabbits were randomly divided into the normal group (n=5) in which the samples were gotten directly, the thrombosis group (TB, n=25) caused by ligating a sect of the posterior vena cava under renal vein to induce thrombosis model, the sham operation group (SH, n=25) that were simply belly open and close to be used as controls. In different periods after acute deep venous thrombosis, morphological change of the endothelial cell apoptosis on target vessels was observed by means of transmission electron microscopy. In situ end-labeling of DNA fragments (TUNEL) was used to detect the endothelial cell apoptosis. Bax and bcl-2 proteins expressed by endothelial cells were determined with immunohistochemical staining. Results: Venous thrombosis models were successfully obtained in all cases. Transmission electron microscopy results showed that apoptosis of partial endothelial cells on target vessels on the 1st day, the 2nd day and the 4th day. TUNEL-positive cell rate reached the maximum on the first day, the second day and there was no significant difference between the two groups (P>0.05), and decreased gradually on the 4th day and the 7th day in TB group. There was significant difference between TB group and SH group respective time (P<0.05-P<0.01). Expression of bcl-2 protein in TB group was increased gradually with the days passing by while bax protein reached the peak on 2nd days and decreased gradually 4th day, 7th day, there was marked difference between TB group and SH group at different time (P<0.05-P<0.01). Conclusions: The apoptosis of the endothelial cells after acute deep venous thrombosis occurs, reaches the peak on the first and the second day and decreases gradually after 2nd days. The bcl-2 and bax participate in the regulation and control of the apoptosis of the endothelial cells.
Objective: To explore the apoptosis of endothelial cells after acute deep venous thrombosis in rabbit and its significanse in the pathological processes. Methods: Fifty-five adult rabbits were randomly divided into the normal group (n=5) in which the samples were gotten directly, the thrombosis group (TB, n=25) caused by ligating a sect of the posterior vena cava under renal vein to induce thrombosis model, the sham operation group (SH, n=25) that were simply belly open and close to be used as controls. In different periods after acute deep venous thrombosis, morphological change of the endothelial cell apoptosis on target vessels was observed by means of transmission electron microscopy. In situ end-labeling of DNA fragments (TUNEL) was used to detect the endothelial cell apoptosis. Bax and bcl-2 proteins expressed by endothelial cells were determined with immunohistochemical staining. Results: Venous thrombosis models were successfully obtained in all cases. Transmission electron microscopy results showed that apoptosis of partial endothelial cells on target vessels on the 1st day, the 2nd day and the 4th day. TUNEL-positive cell rate reached the maximum on the first day, the second day and there was no significant difference between the two groups (P>0.05), and decreased gradually on the 4th day and the 7th day in TB group. There was significant difference between TB group and SH group respective time (P<0.05-P<0.01). Expression of bcl-2 protein in TB group was increased gradually with the days passing by while bax protein reached the peak on 2nd days and decreased gradually 4th day, 7th day, there was marked difference between TB group and SH group at different time (P<0.05-P<0.01). Conclusions: The apoptosis of the endothelial cells after acute deep venous thrombosis occurs, reaches the peak on the first and the second day and decreases gradually after 2nd days. The bcl-2 and bax participate in the regulation and control of the apoptosis of the endothelial cells.
2007, 32(5): 514-516.
Abstract:
Objective: To investigate the role of salvianolate in platelet aggregation and adhesiveness in healthy volunteers, and to provide referece to the administered dose of salvianolate. Methods: Twenty-seven healthy volunteers were randomly divided into three groups:200 mg salvianolate group, 300 mg group and 400 mg group. The drug was given by intravenous infusion within one hour and the blood was drawn at intervals. The plasma drug concentration was determined by high performance liquid chroma-togeraphy (HPLC) and the platelet aggregation and adhesiveness rates were assayed simultaneously;the inhibition rates of them were used to evaluate the intensity of pharmacological effects. Results: The inhibition rates of platelet aggregation and adhesiveness of the 3 groups rose gradually after administration of salvianolate, which had obvious time-effect relationship. The concentration reached peaks at 3-5 hour, and the pharmacological effects lagged behind in the 3 groups. Conclusions: Salvianolate may inhibit the aggregation and adhesiveness of platelet.
Objective: To investigate the role of salvianolate in platelet aggregation and adhesiveness in healthy volunteers, and to provide referece to the administered dose of salvianolate. Methods: Twenty-seven healthy volunteers were randomly divided into three groups:200 mg salvianolate group, 300 mg group and 400 mg group. The drug was given by intravenous infusion within one hour and the blood was drawn at intervals. The plasma drug concentration was determined by high performance liquid chroma-togeraphy (HPLC) and the platelet aggregation and adhesiveness rates were assayed simultaneously;the inhibition rates of them were used to evaluate the intensity of pharmacological effects. Results: The inhibition rates of platelet aggregation and adhesiveness of the 3 groups rose gradually after administration of salvianolate, which had obvious time-effect relationship. The concentration reached peaks at 3-5 hour, and the pharmacological effects lagged behind in the 3 groups. Conclusions: Salvianolate may inhibit the aggregation and adhesiveness of platelet.
2007, 32(5): 517-518.
Abstract:
Objective: To establish an enzyme-linked immunosorbent assay (ELISA) for detection of the antibody of penicillin in human serum. Methods: The ELISA to detect the penicillin antibody was established by adding sera into the polystyrene micro-titer plates coated with penicillin-conjugated rabbit serum albumin and HRP-conjugated goat anti-human IgG. The Penicillin antibody in some clinical samples was detected with this method. Results: The within and between assay CV were 6.8% and 8.4% respectively. The rabbit anti-penicillin antibody, which was obtained from penicillin-conjugated rabbit serum albumin, could control the HRP-anti human IgG reaction. The positive rate of penicillin antibody in patients with different diseases was significantly different. Conclusions: ELISA is more sensitive and specific in clinically detecting and antibody of penicillin.
Objective: To establish an enzyme-linked immunosorbent assay (ELISA) for detection of the antibody of penicillin in human serum. Methods: The ELISA to detect the penicillin antibody was established by adding sera into the polystyrene micro-titer plates coated with penicillin-conjugated rabbit serum albumin and HRP-conjugated goat anti-human IgG. The Penicillin antibody in some clinical samples was detected with this method. Results: The within and between assay CV were 6.8% and 8.4% respectively. The rabbit anti-penicillin antibody, which was obtained from penicillin-conjugated rabbit serum albumin, could control the HRP-anti human IgG reaction. The positive rate of penicillin antibody in patients with different diseases was significantly different. Conclusions: ELISA is more sensitive and specific in clinically detecting and antibody of penicillin.
2007, 32(5): 519-521.
Abstract:
Objective: To observe changes of the level of soluble plasma CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) in patients with various coronary heart diseases and their correlations with the development of acute coronary syndrome (ACS), and to evaluate the significance of sCD40L and MMP-9 as plasma target of plague rupture. Methods: Forty-eight patients with ACS, 17 with stable coronary heart disease (SCHD) and 15 normal controls were concluded in the study. Their plasma levels of sCD40L and MMP-9 were measured with enzyme-linked immunosorbent assay. Results: The plasma level of sCD40L in patients with ACS was significantly higher than that of patients with SCHD and normal controls (P<0.01). MMP-9 level was significantly higher in patients with ACS than in those with SCHD and normal controls (P<0.01). There was a positive correlation between the levels of sCD40L and MMP-9 (P<0.01). Conclusions: The plasma levels of both sCD40L and MMP-9 are elevated significantly in patients with acute coronary syndrome, which suggests that they may have close correlation with the rupture of the unstable atheromatous plagues and may serve as a potential marker of plague stability.
Objective: To observe changes of the level of soluble plasma CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) in patients with various coronary heart diseases and their correlations with the development of acute coronary syndrome (ACS), and to evaluate the significance of sCD40L and MMP-9 as plasma target of plague rupture. Methods: Forty-eight patients with ACS, 17 with stable coronary heart disease (SCHD) and 15 normal controls were concluded in the study. Their plasma levels of sCD40L and MMP-9 were measured with enzyme-linked immunosorbent assay. Results: The plasma level of sCD40L in patients with ACS was significantly higher than that of patients with SCHD and normal controls (P<0.01). MMP-9 level was significantly higher in patients with ACS than in those with SCHD and normal controls (P<0.01). There was a positive correlation between the levels of sCD40L and MMP-9 (P<0.01). Conclusions: The plasma levels of both sCD40L and MMP-9 are elevated significantly in patients with acute coronary syndrome, which suggests that they may have close correlation with the rupture of the unstable atheromatous plagues and may serve as a potential marker of plague stability.
2007, 32(5): 522-524.
Abstract:
Objective: To study the expression of uteroglobin-related protein 1 (UGRP1) in thyroid diseases and its clinical significance. Methods: Eighteen cases of normal thyroid tissue, 23 cases of nodular goiter, 35 cases of thyroid adenoma, 64 cases of Hashimoto's thyroiditis, 43 cases of Graves disease and 32 cases of thyroid carcinoma were involved in he study. Immunohistochemical method (Envision method) was used to detect the expression of UGRP1. Results: UGRP1 was not expressed in nodular goiter or thyroid carcinoma. The positive expression of UGRP1 in normal thyroid tissue, thyroid adenoma and Graves was 5.56%, 2.86% and 9.30% respectively. There was no significant difference among them (P>0.05). UGRP1 was strongly expressed in Hashimoto's thyroiditis, and the rate of positive expression of UGRP1 was 71.88%. The difference was significant between Hashimoto's thyroiditis and other thyroid diseases (P<0.01). Conclusions: UGRP1 is not expressed in nodular goiter or thyroid carcinoma, and weakly expressed in normal thyroid tissue, thyroid adenoma and Graves disease, but strongly expressed in Hashimoto's thyroiditis. UGRP1 is probably involved in the pathogenesis of autoimmune thyroid disease via immunity and inflammation, and may play an important role in the diagnosis and differential diagnosis of Hashimoto's thyroiditis.
Objective: To study the expression of uteroglobin-related protein 1 (UGRP1) in thyroid diseases and its clinical significance. Methods: Eighteen cases of normal thyroid tissue, 23 cases of nodular goiter, 35 cases of thyroid adenoma, 64 cases of Hashimoto's thyroiditis, 43 cases of Graves disease and 32 cases of thyroid carcinoma were involved in he study. Immunohistochemical method (Envision method) was used to detect the expression of UGRP1. Results: UGRP1 was not expressed in nodular goiter or thyroid carcinoma. The positive expression of UGRP1 in normal thyroid tissue, thyroid adenoma and Graves was 5.56%, 2.86% and 9.30% respectively. There was no significant difference among them (P>0.05). UGRP1 was strongly expressed in Hashimoto's thyroiditis, and the rate of positive expression of UGRP1 was 71.88%. The difference was significant between Hashimoto's thyroiditis and other thyroid diseases (P<0.01). Conclusions: UGRP1 is not expressed in nodular goiter or thyroid carcinoma, and weakly expressed in normal thyroid tissue, thyroid adenoma and Graves disease, but strongly expressed in Hashimoto's thyroiditis. UGRP1 is probably involved in the pathogenesis of autoimmune thyroid disease via immunity and inflammation, and may play an important role in the diagnosis and differential diagnosis of Hashimoto's thyroiditis.
2007, 32(5): 525-527.
Abstract:
Objective: To investigate the efficacy and complication of high dose of corticosteroid in treatment of proliferative hemangiomas of infants. Methods: The proliferative hemangioma infants were administered prednisone in the first 8 weeks according to their wight (4 mg/kg) and the dosage was decreased to 2 tablets in the 9th week and 1 tablet in the 10th week;the medicine was taken orally once every two days at 8-9 am for 10 weeks. The outcome of treatment, courses of therapy, and short and long term of side effects were analyzed. Results: The overall response rate was 90% in proliferative hemangiomas infants treated with Corticosteroid;92% of the infants entered into stable involuting stage with no serious short or long term complications after 1-2 courses. Conclusions: 1-2 courses of high dose of corticosteroids provide a safe and effective modality for treatment of proliferative hemangiomas in infants. It is worth popularizing.
Objective: To investigate the efficacy and complication of high dose of corticosteroid in treatment of proliferative hemangiomas of infants. Methods: The proliferative hemangioma infants were administered prednisone in the first 8 weeks according to their wight (4 mg/kg) and the dosage was decreased to 2 tablets in the 9th week and 1 tablet in the 10th week;the medicine was taken orally once every two days at 8-9 am for 10 weeks. The outcome of treatment, courses of therapy, and short and long term of side effects were analyzed. Results: The overall response rate was 90% in proliferative hemangiomas infants treated with Corticosteroid;92% of the infants entered into stable involuting stage with no serious short or long term complications after 1-2 courses. Conclusions: 1-2 courses of high dose of corticosteroids provide a safe and effective modality for treatment of proliferative hemangiomas in infants. It is worth popularizing.
2007, 32(5): 527-528.
Abstract:
Objective: To investigate the clinical features and treatment of delayed traumatic intracranial hematoma (DTICH). Methods: Twenty-three cases of DTICH were included in the study. The hemotoma in 12 cases were removed and decompressed by crinial bone resection and 5 cases were removed by means of craniotomy with small bone window resection under microscope. 6 cases received expectant treatment. Results: Of the 23 patients with DTICH, 7 were cured, 9 could take care of themselves, 1 was in vegetative state and 6 died. Conclusions: Position of the trauma, skull fracture, cerebral contusion and laceration are the factors related to delayed traumatic intracranial hematoma. Early diagnosis and treatment is key to successful treatment of patients with DTICH.
Objective: To investigate the clinical features and treatment of delayed traumatic intracranial hematoma (DTICH). Methods: Twenty-three cases of DTICH were included in the study. The hemotoma in 12 cases were removed and decompressed by crinial bone resection and 5 cases were removed by means of craniotomy with small bone window resection under microscope. 6 cases received expectant treatment. Results: Of the 23 patients with DTICH, 7 were cured, 9 could take care of themselves, 1 was in vegetative state and 6 died. Conclusions: Position of the trauma, skull fracture, cerebral contusion and laceration are the factors related to delayed traumatic intracranial hematoma. Early diagnosis and treatment is key to successful treatment of patients with DTICH.
2007, 32(5): 529-531.
Abstract:
Objective: To sum up the clinical experience of application of EB composite resin periodontal splint in treatment of the chronic pariodontitis. Methods: The stainless steel wire, the steel rectifying wire, the dental arc and composite resin combined with the periodontal splint were used to fix the loose teeth of 27 patients. One month after fixation with EB composite resin periodontal splint, the patients were followed up. Then, patients would be followed once every 3 months to a half year, in order to observe the clinical symptom, the loose degree of tooth, the periodontal bag situation and the function of chewing. At one time, X-ray was taken to observe alveolar bone situation and judge the result. Results: The patients were followed up for 3 to 5 years, 6 cases were good, 4 cases were improved. The effective rate amounted to 88.9%. Conclusions: The loose teeth are linked into a whole unit by the method, stabilizing loose teeth and stress, enhancing the chew function and efficiently controlling the chronic pariodontitis development.
Objective: To sum up the clinical experience of application of EB composite resin periodontal splint in treatment of the chronic pariodontitis. Methods: The stainless steel wire, the steel rectifying wire, the dental arc and composite resin combined with the periodontal splint were used to fix the loose teeth of 27 patients. One month after fixation with EB composite resin periodontal splint, the patients were followed up. Then, patients would be followed once every 3 months to a half year, in order to observe the clinical symptom, the loose degree of tooth, the periodontal bag situation and the function of chewing. At one time, X-ray was taken to observe alveolar bone situation and judge the result. Results: The patients were followed up for 3 to 5 years, 6 cases were good, 4 cases were improved. The effective rate amounted to 88.9%. Conclusions: The loose teeth are linked into a whole unit by the method, stabilizing loose teeth and stress, enhancing the chew function and efficiently controlling the chronic pariodontitis development.
2007, 32(5): 531-532.
Abstract:
Objective: To investigate the buccal fat pad for filling in wounds created by pulling a tooth in resection of cysts and preventing oroantral fistula. Methods: The buccal fat pad was used for filling in wounds created by pulling a tooth in resection of cysts and preventing oroantral fistula in 14 patients with cyst of maxilla. Results: Surgery succeeded in 14 patients. After half a year, the surface mucous membrane quality of material, the luster and periphery the mucous membrane was not easy to differentiate from the adjacent mucous. The mouth-opening was not limited and the shallow vestibulum oris was not found. Conclusions: This surgery is simple with the hidden donor area and less complications.
Objective: To investigate the buccal fat pad for filling in wounds created by pulling a tooth in resection of cysts and preventing oroantral fistula. Methods: The buccal fat pad was used for filling in wounds created by pulling a tooth in resection of cysts and preventing oroantral fistula in 14 patients with cyst of maxilla. Results: Surgery succeeded in 14 patients. After half a year, the surface mucous membrane quality of material, the luster and periphery the mucous membrane was not easy to differentiate from the adjacent mucous. The mouth-opening was not limited and the shallow vestibulum oris was not found. Conclusions: This surgery is simple with the hidden donor area and less complications.
2007, 32(5): 533-535.
Abstract:
Objective: To discuss the multifunctional conservative neck dissection in the treatment of thyroid papillary carcinoma. Methods: The data of 52 patients with thyroid papillary carcinoma were analyzed for the operational technique in multifunctional conservative neck dissection preserving cervical plexus retrospectively. Results: In the group, the rate of lymph node metastasis was 66%. There were no impairment of sensation of ears and lower necks and upper shoulders and no muscles of neck atrophy. Conclusions: The preservation of cervical plexus in the multifunctional conservative neck dissection for thyroid papillary carcinoma does not increase the recurrence of the lymph node metastasis. However, it can protect the sensation of ears, lower necks and upper shoulders.
Objective: To discuss the multifunctional conservative neck dissection in the treatment of thyroid papillary carcinoma. Methods: The data of 52 patients with thyroid papillary carcinoma were analyzed for the operational technique in multifunctional conservative neck dissection preserving cervical plexus retrospectively. Results: In the group, the rate of lymph node metastasis was 66%. There were no impairment of sensation of ears and lower necks and upper shoulders and no muscles of neck atrophy. Conclusions: The preservation of cervical plexus in the multifunctional conservative neck dissection for thyroid papillary carcinoma does not increase the recurrence of the lymph node metastasis. However, it can protect the sensation of ears, lower necks and upper shoulders.
2007, 32(5): 535-536.
Abstract:
Objective: To investigate the value of blood and urine β2-microglobulin (β2-MG) in the early stage of hypertensive renal damage. Methods: The blood and urine β2-MG, as well as the serum creatinine (sCr) of 101 hypertension patients were detected by radioimmunity and enzymic method respectively. The creatinine clearance was calculated by CoCK-Croft-Gualt and the results were compared between the groups. Results: The Ccr of group B and C was obviously lower than that of group A (P<0.01), but the urine β2-MG of the two groups was obviously higher than that of group A (P<0.05-P<0.01);Blood β2-MG of the control group was significantly lower than that of group A, B and C (P<0.01) and its urine β2-MG was lower than that of group B and C significantly (P<0.01). Conclusions: It is of great diagnostic and prevent significance to detect the blood and urine β2-MG in patients with early renal damage caused by hypertension.
Objective: To investigate the value of blood and urine β2-microglobulin (β2-MG) in the early stage of hypertensive renal damage. Methods: The blood and urine β2-MG, as well as the serum creatinine (sCr) of 101 hypertension patients were detected by radioimmunity and enzymic method respectively. The creatinine clearance was calculated by CoCK-Croft-Gualt and the results were compared between the groups. Results: The Ccr of group B and C was obviously lower than that of group A (P<0.01), but the urine β2-MG of the two groups was obviously higher than that of group A (P<0.05-P<0.01);Blood β2-MG of the control group was significantly lower than that of group A, B and C (P<0.01) and its urine β2-MG was lower than that of group B and C significantly (P<0.01). Conclusions: It is of great diagnostic and prevent significance to detect the blood and urine β2-MG in patients with early renal damage caused by hypertension.
2007, 32(5): 537-538.
Abstract:
Objective: To investigate the causes of flap necrosis after the secondary operation for auricle reconstruction. Methods: Auricle reconstruction was performed using soft tissue skin expander and autogenous rib cartilage framework. All or part of the auricle flap necrosis occurred in four patients in the early stages. The causes of the necrosis were analyzed in-depth. Results: Flap necrosis was dry, and caused by arterial insufficiency. The necrosis was mainly caused by improper design and operation. Conclusions: The operation method is modified based on the causes of flap necrosis and the occurrence of similar situations is avoided.
Objective: To investigate the causes of flap necrosis after the secondary operation for auricle reconstruction. Methods: Auricle reconstruction was performed using soft tissue skin expander and autogenous rib cartilage framework. All or part of the auricle flap necrosis occurred in four patients in the early stages. The causes of the necrosis were analyzed in-depth. Results: Flap necrosis was dry, and caused by arterial insufficiency. The necrosis was mainly caused by improper design and operation. Conclusions: The operation method is modified based on the causes of flap necrosis and the occurrence of similar situations is avoided.
2007, 32(5): 539-540.
Abstract:
Objective: To investigate the security and excellence of peritoneoscopy in treatment of benign ovarian tumor. Methods: One hundred and sixty-one patients with benign ovarian tumor were divided into two groups. Seventy-nine patients undergoing peritoneoscopy were compared with eighty-two patients receiving laparotomy. Results: The operative time, the amounts of bleeding, the mean time of bowel function recover, the postoperative morbidity rate and the mean postoperative hospital stay were significantly less than those of laparotomy group (P<0.001). No one used analgesic drug in peritoneoscopy group. All of the peritoneoscopy group were pulled out of urinary catheter and got out of beds six hours postoperatively. But all of the laparotomy group were used analgesic drugs, were pulled out of urinary catheter and got out of beds twenty-four hours postoperatively. Conclusions: Peritoneoscopy in treatment of benign ovarian tumor is worthy of being advocated owing to its micro-incision and benefits such as shorter operative time, less blood loss, quick recovered and shorter hospital stay.
Objective: To investigate the security and excellence of peritoneoscopy in treatment of benign ovarian tumor. Methods: One hundred and sixty-one patients with benign ovarian tumor were divided into two groups. Seventy-nine patients undergoing peritoneoscopy were compared with eighty-two patients receiving laparotomy. Results: The operative time, the amounts of bleeding, the mean time of bowel function recover, the postoperative morbidity rate and the mean postoperative hospital stay were significantly less than those of laparotomy group (P<0.001). No one used analgesic drug in peritoneoscopy group. All of the peritoneoscopy group were pulled out of urinary catheter and got out of beds six hours postoperatively. But all of the laparotomy group were used analgesic drugs, were pulled out of urinary catheter and got out of beds twenty-four hours postoperatively. Conclusions: Peritoneoscopy in treatment of benign ovarian tumor is worthy of being advocated owing to its micro-incision and benefits such as shorter operative time, less blood loss, quick recovered and shorter hospital stay.
2007, 32(5): 541-543.
Abstract:
Objective: To explore the incidence of post-stroke depression and its related factors in the young and middle aged people. Methods: Ninety-six patients with cerebral stroke in the young and middle-aged people were investigated by using HAMD and Chinese scale of clinical neurologic deficit. The related factors such as the location and quantity of lesions, complication, sex and culture background were analyzed with the statistical method. Results: Incidence of post-stroke depression in the young and middle-aged people was about 36.46%. It was not related with sex, culture background, profession, the location of lesions, the clinical neurological deficit and the activity of daily living (P>0.05). But it was related with the hobby of tobacco and alcohol, and complicating hypertension (P<0.05-P<0.005). Conclusions: The post-stroke depression is the common complication after stroke in the young and middle-aged people. It directly affects the prognosis of stroke. The early prevention, diagnosis and treatment of post-stroke depression should be emphasized.
Objective: To explore the incidence of post-stroke depression and its related factors in the young and middle aged people. Methods: Ninety-six patients with cerebral stroke in the young and middle-aged people were investigated by using HAMD and Chinese scale of clinical neurologic deficit. The related factors such as the location and quantity of lesions, complication, sex and culture background were analyzed with the statistical method. Results: Incidence of post-stroke depression in the young and middle-aged people was about 36.46%. It was not related with sex, culture background, profession, the location of lesions, the clinical neurological deficit and the activity of daily living (P>0.05). But it was related with the hobby of tobacco and alcohol, and complicating hypertension (P<0.05-P<0.005). Conclusions: The post-stroke depression is the common complication after stroke in the young and middle-aged people. It directly affects the prognosis of stroke. The early prevention, diagnosis and treatment of post-stroke depression should be emphasized.
2007, 32(5): 543-545.
Abstract:
Objective: To investigate the surgical treatment strategies for raising cure rate and decreasing fatality of severe acute pancreatitis. Methods: The clinical data of non-operative treatment and operative treatment for 52 patients with severe acute pancreatitis were retrospectively analyzed. Results: For the non-operative treatment (n=37), the cure rate was 89.2% and fatality 8.1%, while for the operative treatment (n=15), the cure rate was 86.7% and fatality 13.3% (P>0.05). In the severe gradeⅠoperation rate was 24.1%, cure rate 93.1% and fatality 3.4%. In the severe gradeⅡoperation rate was 34.8%, the cure rate 82.6% and fatality 17.4% (P>0.05). The total operation rate was 28.8%, total cure rate 88.5% and total fatality 9.6%. Conclusions: The indication and timing for operation should be strictly managed. The surgical treatment strategies should be that non-operative comprehensive treatment is dominant and operative treatment is subordinate, which can raise the cure rate and decrease the fatality of severe acute pancreatitis.
Objective: To investigate the surgical treatment strategies for raising cure rate and decreasing fatality of severe acute pancreatitis. Methods: The clinical data of non-operative treatment and operative treatment for 52 patients with severe acute pancreatitis were retrospectively analyzed. Results: For the non-operative treatment (n=37), the cure rate was 89.2% and fatality 8.1%, while for the operative treatment (n=15), the cure rate was 86.7% and fatality 13.3% (P>0.05). In the severe gradeⅠoperation rate was 24.1%, cure rate 93.1% and fatality 3.4%. In the severe gradeⅡoperation rate was 34.8%, the cure rate 82.6% and fatality 17.4% (P>0.05). The total operation rate was 28.8%, total cure rate 88.5% and total fatality 9.6%. Conclusions: The indication and timing for operation should be strictly managed. The surgical treatment strategies should be that non-operative comprehensive treatment is dominant and operative treatment is subordinate, which can raise the cure rate and decrease the fatality of severe acute pancreatitis.
2007, 32(5): 546-548.
Abstract:
Objective: To investigate the risk factors for cerebral infarction (CI) resulting from transient ischemic attack (TIA). Methods: The clinical data of 110 hospitalized patients with TIA were evaluated. Results: Thirty-eight patients (34.5%) suffered from cerebral infarction (CI) following TIA in 110 patients. Eight patients with CI resulted from vertebra-basilar artery system, and 28 resulted from internal carotid artery system. There was significantly different in two artery systems (P>0.05). The risks of cerebral infarction were significantly increased in the patients whose syndromes lasted for over 30 min, the patients with 5 attacks within 24 h, the patients who were treated beyond 24 h of syndrome onset, or the treated patients with 5 attacks or more (P<0.05-P<0.005). The high blood pressure, hyperglycaemia and hyperlipoidemia often happened in the patients with CI (P<0.05-P<0.01). Conclusions: The risk is high for the patients to develop CI if patients with TIA last for long time or frequency of attack is much more, or therapy is not yet in time, especially for the patients with high blood pressure, hyperglycaemia and hyperlipoidemia.
Objective: To investigate the risk factors for cerebral infarction (CI) resulting from transient ischemic attack (TIA). Methods: The clinical data of 110 hospitalized patients with TIA were evaluated. Results: Thirty-eight patients (34.5%) suffered from cerebral infarction (CI) following TIA in 110 patients. Eight patients with CI resulted from vertebra-basilar artery system, and 28 resulted from internal carotid artery system. There was significantly different in two artery systems (P>0.05). The risks of cerebral infarction were significantly increased in the patients whose syndromes lasted for over 30 min, the patients with 5 attacks within 24 h, the patients who were treated beyond 24 h of syndrome onset, or the treated patients with 5 attacks or more (P<0.05-P<0.005). The high blood pressure, hyperglycaemia and hyperlipoidemia often happened in the patients with CI (P<0.05-P<0.01). Conclusions: The risk is high for the patients to develop CI if patients with TIA last for long time or frequency of attack is much more, or therapy is not yet in time, especially for the patients with high blood pressure, hyperglycaemia and hyperlipoidemia.
2007, 32(5): 549-551.
Abstract:
Objective: To investigate the correlation between the increase of bleeding volume in patients with intracerebral hemorrhage (ICH) at the early stage and the outcome. Methods: The clinical data of 132 patients with ICH were divided into two groups:the group with increased bleeding volume and the group with unchanged bleeding volume. Results: Twenty-six of the 64 cases died in the increased hemorrhage group and 11 of 68 cases died in the unchanged hemorrhage volume group (P<0.005). Conclusions: The death rate is high in the early stage of ICH. The reason for death is the increase of bleeding volume, which is relevant to hypertension, regular administration of aspirin and so on.
Objective: To investigate the correlation between the increase of bleeding volume in patients with intracerebral hemorrhage (ICH) at the early stage and the outcome. Methods: The clinical data of 132 patients with ICH were divided into two groups:the group with increased bleeding volume and the group with unchanged bleeding volume. Results: Twenty-six of the 64 cases died in the increased hemorrhage group and 11 of 68 cases died in the unchanged hemorrhage volume group (P<0.005). Conclusions: The death rate is high in the early stage of ICH. The reason for death is the increase of bleeding volume, which is relevant to hypertension, regular administration of aspirin and so on.
2007, 32(5): 551-553.
Abstract:
Objective: To evaluate the clinical efficacy and toxicity of combined gemcitabine and cisplatin in treatment of advanced non-small-cell lung cancer (NSCLC). Methods: Forty-two patients pathologically confirmed as stage Ⅲ or Ⅳ NSCLC were given Gemcitabine on d1, and d8 at a dose of 1 g/m2 and cisplatin on d1-3 at a dose of 30 mg/m2. The chemotherapy was repeated every 21 days. Each patient was treated for at least 2 cycles. Results: Complete response was observed in 1case, partial response in 17 cases, no response in 16 cases and progression in 8 cases. The overall response rate was 42.9%. The main toxicities were gradeⅠ-Ⅱmyelosuppression, nausea and vomiting;however, there was no severe grade Ⅳ damage or obvious liver and kidney damage. Conclusions: Combination of gemcitabine and cisplatin is effective and well-tolerated in the treatment of advanced NSCLC.
Objective: To evaluate the clinical efficacy and toxicity of combined gemcitabine and cisplatin in treatment of advanced non-small-cell lung cancer (NSCLC). Methods: Forty-two patients pathologically confirmed as stage Ⅲ or Ⅳ NSCLC were given Gemcitabine on d1, and d8 at a dose of 1 g/m2 and cisplatin on d1-3 at a dose of 30 mg/m2. The chemotherapy was repeated every 21 days. Each patient was treated for at least 2 cycles. Results: Complete response was observed in 1case, partial response in 17 cases, no response in 16 cases and progression in 8 cases. The overall response rate was 42.9%. The main toxicities were gradeⅠ-Ⅱmyelosuppression, nausea and vomiting;however, there was no severe grade Ⅳ damage or obvious liver and kidney damage. Conclusions: Combination of gemcitabine and cisplatin is effective and well-tolerated in the treatment of advanced NSCLC.
2007, 32(5): 554-555.
Abstract:
Objective: To summarize the clinical features of pulmonary tuberculosis complicated with diabetes mellitus and to improve the treatment effects. Methods: The clinical data of 346 patients suffering from pulmonary tuberculosis accompanied with diabetes mellitus were analyzed retrospectively. Results: The incidence of pulmonary tuberculosis comlicated with diabetes mellitus tended to increase in the middle aged and elderly people. Women were more easily affected than men (P<0.05). Specific features included wide spreading of the focuses of infection, which were mainly in the caseous form and accmpanied by cavity, high positive rate of bacteriologic sputum, poor curative result and high occurrence of relapse. Most of the patients had type 2 diabetes mellitus mellitus. Early use of insulin might achieve better results than oral medicine in symptom improvement, cavity closure and the rate of sputum turning to negative (P<0.05-P<0.005). The treatment duration lasted for 1.5-2.0 years. Conclusions: The patients with pulmonary tuberculosis complicated with diabetes mellitus have special clinical features. Control of blood glucose is the key for successful treatment. Early insulin has better treatment effects than oral medication.
Objective: To summarize the clinical features of pulmonary tuberculosis complicated with diabetes mellitus and to improve the treatment effects. Methods: The clinical data of 346 patients suffering from pulmonary tuberculosis accompanied with diabetes mellitus were analyzed retrospectively. Results: The incidence of pulmonary tuberculosis comlicated with diabetes mellitus tended to increase in the middle aged and elderly people. Women were more easily affected than men (P<0.05). Specific features included wide spreading of the focuses of infection, which were mainly in the caseous form and accmpanied by cavity, high positive rate of bacteriologic sputum, poor curative result and high occurrence of relapse. Most of the patients had type 2 diabetes mellitus mellitus. Early use of insulin might achieve better results than oral medicine in symptom improvement, cavity closure and the rate of sputum turning to negative (P<0.05-P<0.005). The treatment duration lasted for 1.5-2.0 years. Conclusions: The patients with pulmonary tuberculosis complicated with diabetes mellitus have special clinical features. Control of blood glucose is the key for successful treatment. Early insulin has better treatment effects than oral medication.
2007, 32(5): 556-558.
Abstract:
Objective: To investigate the conservative treatment and therapeutic results of longitudinal fractures of the posterior teeth. Methods: Twenty-seven patients were all treated by fixing with ligature, root canal therapy and finally crown restoration. Results: All the patients were followed up for 2 years. The teeth were extracted due to failure in two patients while 25 patients were treated conservatively and effectively with the rate of success at 92.59%. Conclusions: With fixed early and appropriate treatment, the teeth can be conserved effectively and have good masticatory function.
Objective: To investigate the conservative treatment and therapeutic results of longitudinal fractures of the posterior teeth. Methods: Twenty-seven patients were all treated by fixing with ligature, root canal therapy and finally crown restoration. Results: All the patients were followed up for 2 years. The teeth were extracted due to failure in two patients while 25 patients were treated conservatively and effectively with the rate of success at 92.59%. Conclusions: With fixed early and appropriate treatment, the teeth can be conserved effectively and have good masticatory function.
2007, 32(5): 558-559.
Abstract:
Objective: To explore the clinical value of chest biopsy by CT-guided percutaneous fine needle punctures in diagnosis of space-occupying lesions of the chest. Methods: Thirty-three cases of the chest lesion were performed biopsy by combined use of 17G and 18G soft-tissue-cutting biopsy needles, 21G fine-needle and PTC needle with the guide of CT. Results: Among the 33 cases, 25 were confirmed by clinical data and pathological examination to suffer from primary malignan tumor, 1 from tuberculosis, 1 from thymus cancer and 2 from metastatic carcinoma. Indefinite diagnosis was made in 4 cases. The diagnosis rate was 87.9%. After operation, pneumothorax occurred in 1 case and traces of blood in sputum were found in 3 cases. Conclusions: Chest biopsy by CT-guided percutaneous fine needle punctures is a safe and practical technique and may be widely used in clinical application.
Objective: To explore the clinical value of chest biopsy by CT-guided percutaneous fine needle punctures in diagnosis of space-occupying lesions of the chest. Methods: Thirty-three cases of the chest lesion were performed biopsy by combined use of 17G and 18G soft-tissue-cutting biopsy needles, 21G fine-needle and PTC needle with the guide of CT. Results: Among the 33 cases, 25 were confirmed by clinical data and pathological examination to suffer from primary malignan tumor, 1 from tuberculosis, 1 from thymus cancer and 2 from metastatic carcinoma. Indefinite diagnosis was made in 4 cases. The diagnosis rate was 87.9%. After operation, pneumothorax occurred in 1 case and traces of blood in sputum were found in 3 cases. Conclusions: Chest biopsy by CT-guided percutaneous fine needle punctures is a safe and practical technique and may be widely used in clinical application.
2007, 32(5): 560-561.
Abstract:
Objective: To explore the relation between the nucleic acid content of hepatitis B virus (HBV) and HBV markers, liver injury. Methods: One hundred and twenty-six patients suffering from hepatitis B received HBV DNA analysis. Fluorescence ration PCR analysis was performed for HBV DNA quantifying assessment. HBV markers were detected by ELISA. Results: Serum HBeAg was related to HBV DNA (P<0.01). The highest HBV DNA levels were presented in sera positive for both HBsAg and HbeAg (P<0.05). Serum alanine amjnotransferase level and HBV DNA content were correlated. Conclusions: The quantity of HBV DNA is related to HbeAg. Liver injury stage is related to serum HBV DNA content.
Objective: To explore the relation between the nucleic acid content of hepatitis B virus (HBV) and HBV markers, liver injury. Methods: One hundred and twenty-six patients suffering from hepatitis B received HBV DNA analysis. Fluorescence ration PCR analysis was performed for HBV DNA quantifying assessment. HBV markers were detected by ELISA. Results: Serum HBeAg was related to HBV DNA (P<0.01). The highest HBV DNA levels were presented in sera positive for both HBsAg and HbeAg (P<0.05). Serum alanine amjnotransferase level and HBV DNA content were correlated. Conclusions: The quantity of HBV DNA is related to HbeAg. Liver injury stage is related to serum HBV DNA content.
2007, 32(5): 562-563.
Abstract:
Objective: To explore relationships between the type of soft disc herniation causing mild cervical myelopathy and effectof conservative treatment. Methods: Twenty-eight patients with mild cervical myelopathy caused by soft disc herniation were selected with JOA scores>12 and divided into two groups according to the therapeutic efficacy. In 16 patients (Group A), their myelopathy improved or their condition remained stable while in the other 12 patients (Group B), they deteriorated neurologically or their disability remained unchanged. The difference of the types of soft disc herniation was compared by MRI. Results: Before treatment, JOA score in group A was 13.94±1.44, in group B 14.1±1.1, without the statistic significance between two groups (P>0.05). After treatment, JOA score in group A was 16.0±0.73, in group B 12.5±0.80 (P<0.001). Diffuse-type herniation was present in 63% of the patients in Group A and 25% in Group B (P=0.067), while median-type herniation was diagnosed in 75% in Group A and 25% in Group B (P=0.020). Conclusions: Patients with a median type and diffuse type CDH on MRI may be more suitable for the conservative treatment.
Objective: To explore relationships between the type of soft disc herniation causing mild cervical myelopathy and effectof conservative treatment. Methods: Twenty-eight patients with mild cervical myelopathy caused by soft disc herniation were selected with JOA scores>12 and divided into two groups according to the therapeutic efficacy. In 16 patients (Group A), their myelopathy improved or their condition remained stable while in the other 12 patients (Group B), they deteriorated neurologically or their disability remained unchanged. The difference of the types of soft disc herniation was compared by MRI. Results: Before treatment, JOA score in group A was 13.94±1.44, in group B 14.1±1.1, without the statistic significance between two groups (P>0.05). After treatment, JOA score in group A was 16.0±0.73, in group B 12.5±0.80 (P<0.001). Diffuse-type herniation was present in 63% of the patients in Group A and 25% in Group B (P=0.067), while median-type herniation was diagnosed in 75% in Group A and 25% in Group B (P=0.020). Conclusions: Patients with a median type and diffuse type CDH on MRI may be more suitable for the conservative treatment.
2007, 32(5): 564-566.
Abstract:
Objective: To investigate the hollow lag screw fixation and the artificial joint replacement in the treatment of femoral neck fractures. Methods: The hollow screw fixation in 35 patients, and femoral head replacement or total hip arthroplasty in 22 patients were reviewed. Results: There was no significant difference in the incidence of complication and reoperation rate, time to get out of bed and long-term functional score between the two groups (P>0.05). The hospitalization time, the expenses, operation time, surgical trauma and blood loss in the fixation group were significantly less than those in the hip replacement group (P<0.001). Conclusions: The effective internal fixation still is effective in treatment of fresh femoral neck fracture.
Objective: To investigate the hollow lag screw fixation and the artificial joint replacement in the treatment of femoral neck fractures. Methods: The hollow screw fixation in 35 patients, and femoral head replacement or total hip arthroplasty in 22 patients were reviewed. Results: There was no significant difference in the incidence of complication and reoperation rate, time to get out of bed and long-term functional score between the two groups (P>0.05). The hospitalization time, the expenses, operation time, surgical trauma and blood loss in the fixation group were significantly less than those in the hip replacement group (P<0.001). Conclusions: The effective internal fixation still is effective in treatment of fresh femoral neck fracture.
2007, 32(5): 566-568.
Abstract:
Objective: To explore the feasibility and safety of hip arthroplasty in treatment of femoral neck fracture and propose the perioperative approach and the methods of arthroplasty. Methods: Retrospective analysis of the efficacy and complications of artificial joint replacement in 26 patients aged more than 70 years old with fractures of the femoral neck from March 2000 to September 2006 were performed. The average duration of hospitalization, the surgical time, the intraoperative and postoperative bleeding, the blood transfusion, Harris score, the time to get out of bed were compared between the hemiarthroplasty group of 20 patients and total hip replacement group of 6 patients. Results: No patients in the two groups died intraoperatively and postoperatively. Harris score improved by an average of 38.2 and the excellent rate was 88.46%. The complications occurred in 5 patients with the incidence of 19.23%. The operative time, the intraoperative and postoperative bleeding, blood transfusion, the incidence of complications in hemiarthroplasty group were significantly lower than those in the total hip replacement group (P<0.01-P<0.001). There were no significant differences in Harris and the score, time to get out of bed, the average length of stay between the two groups (P<0.001-P<0.01). Conclusions: Elderly patients with femoral neck fracture, artificial joint replacement for effective treatment, can significantly improve the patient's quality of life. The correct perioperative management can help such patients pass through the perioperative period and achieve good results. For the two surgical approaches, hemiarthroplasty is more suitable for 80 older patients with femoral neck fracture.
Objective: To explore the feasibility and safety of hip arthroplasty in treatment of femoral neck fracture and propose the perioperative approach and the methods of arthroplasty. Methods: Retrospective analysis of the efficacy and complications of artificial joint replacement in 26 patients aged more than 70 years old with fractures of the femoral neck from March 2000 to September 2006 were performed. The average duration of hospitalization, the surgical time, the intraoperative and postoperative bleeding, the blood transfusion, Harris score, the time to get out of bed were compared between the hemiarthroplasty group of 20 patients and total hip replacement group of 6 patients. Results: No patients in the two groups died intraoperatively and postoperatively. Harris score improved by an average of 38.2 and the excellent rate was 88.46%. The complications occurred in 5 patients with the incidence of 19.23%. The operative time, the intraoperative and postoperative bleeding, blood transfusion, the incidence of complications in hemiarthroplasty group were significantly lower than those in the total hip replacement group (P<0.01-P<0.001). There were no significant differences in Harris and the score, time to get out of bed, the average length of stay between the two groups (P<0.001-P<0.01). Conclusions: Elderly patients with femoral neck fracture, artificial joint replacement for effective treatment, can significantly improve the patient's quality of life. The correct perioperative management can help such patients pass through the perioperative period and achieve good results. For the two surgical approaches, hemiarthroplasty is more suitable for 80 older patients with femoral neck fracture.
2007, 32(5): 569-571.
Abstract:
Objective: To evaluate and summarize the experience of early complication management in the ntensive care period after orthotopic liver transplantation (OLT). Methods: The clinical data of 9 patients undergoing OLT in our hospital from Jun 2002 to Apr 2005 were retrospectively analyzed. Results: Eight patients were cured and 1 case died of severe infection and multiple organ failure syndrome. The perioperative survival rate was 8/9. The mean extubation time of 9 OLT patients was 11.3±4.8 days. The main complications during the ntensive care period were bacteria infection (2 cases), fungal infection (1 case), acute rejection (2 cases), inferior vena cava stricture (1 case), and acute renal insufficiency (1 case). One case died of respiratory failure secondary to severe pulmonary infection. Conclusions: It is important to understand rules of pathophysiological changes and effective perioperative management to decrease the occurrence of complication in ntensive care period after OLT.
Objective: To evaluate and summarize the experience of early complication management in the ntensive care period after orthotopic liver transplantation (OLT). Methods: The clinical data of 9 patients undergoing OLT in our hospital from Jun 2002 to Apr 2005 were retrospectively analyzed. Results: Eight patients were cured and 1 case died of severe infection and multiple organ failure syndrome. The perioperative survival rate was 8/9. The mean extubation time of 9 OLT patients was 11.3±4.8 days. The main complications during the ntensive care period were bacteria infection (2 cases), fungal infection (1 case), acute rejection (2 cases), inferior vena cava stricture (1 case), and acute renal insufficiency (1 case). One case died of respiratory failure secondary to severe pulmonary infection. Conclusions: It is important to understand rules of pathophysiological changes and effective perioperative management to decrease the occurrence of complication in ntensive care period after OLT.
2007, 32(5): 572-573.
Abstract:
Objective: To investigate the results of the operative treatment of Pilon fracture by using the external fixation and compare the results with internal fixation. Methods: Thirty-six patients with Pilon fractures were treated with single arm-three-diementionl external fixator or T shape basitinni external fixator as shaft axial fixation or tibial supportive plate or AO three-leaves plate and simple internal fixation of the fibula to restore anatomical reduction of the ankle. Results: All the patients were followed up for 4 to 60 months. All fractures were united according to the Mazur scoring system and the excellent and good rate was 75%. Conclusions: External fixation with limited internal of Pilon fractures has such advantages as simple operative technique, less injuries, anatomic reduction of ankle, earlier rehabilitation and satisfactory functional recovery.
Objective: To investigate the results of the operative treatment of Pilon fracture by using the external fixation and compare the results with internal fixation. Methods: Thirty-six patients with Pilon fractures were treated with single arm-three-diementionl external fixator or T shape basitinni external fixator as shaft axial fixation or tibial supportive plate or AO three-leaves plate and simple internal fixation of the fibula to restore anatomical reduction of the ankle. Results: All the patients were followed up for 4 to 60 months. All fractures were united according to the Mazur scoring system and the excellent and good rate was 75%. Conclusions: External fixation with limited internal of Pilon fractures has such advantages as simple operative technique, less injuries, anatomic reduction of ankle, earlier rehabilitation and satisfactory functional recovery.
2007, 32(5): 574-576.
Abstract:
Objective: To evaluate the surgical efficacy of the modified Madigan prostatectomy for prostatic hyperplasia (BPH). Methods: A retrospective analysis of 22 patients with BPH was conducted and the method and the feature of the operation were described. Results: One patient needed urethral repair in 3 patients with urethral injury and the other 19 patients had no urethral injury. One patient needed blood transfusion with the intraoperative blood loss of 950 ml. The blood loss in the other 21 patients ranged from 100 to 650 ml and no blood transfusion were needed in the operation. The operating time was between 60 and 120 minutes. Follow-up examinations for 2 to 14 months showed that no antegrade ejaculation, incontinence, urethral stricture or impotence occurred. Conclusions: The modified Madigan prostatectomy has the advantages such as the less postoperative bleeding, faster recovery, less complications and hospitalization time. It is an ideal open operation procedure.
Objective: To evaluate the surgical efficacy of the modified Madigan prostatectomy for prostatic hyperplasia (BPH). Methods: A retrospective analysis of 22 patients with BPH was conducted and the method and the feature of the operation were described. Results: One patient needed urethral repair in 3 patients with urethral injury and the other 19 patients had no urethral injury. One patient needed blood transfusion with the intraoperative blood loss of 950 ml. The blood loss in the other 21 patients ranged from 100 to 650 ml and no blood transfusion were needed in the operation. The operating time was between 60 and 120 minutes. Follow-up examinations for 2 to 14 months showed that no antegrade ejaculation, incontinence, urethral stricture or impotence occurred. Conclusions: The modified Madigan prostatectomy has the advantages such as the less postoperative bleeding, faster recovery, less complications and hospitalization time. It is an ideal open operation procedure.
2007, 32(5): 576-578.
Abstract:
Objective: To investigate the safety and efficacy of painless gastroscopy for aged patients. Methods: One hundred and sixty elderly patients were divided into sedative group (n=160) and control group (n=101). The sedative group received propofol and midazolam intravenously in addition to routine operation. The reaction, operative duration and conscious time were compared between the two groups. The changes of blood pressure, heart rate and blood oxygen saturation (SaO2) before and after operation were recorded and analyzed. Results: 99.4% of the patients in the sedative group and 35% in the control group did not complain of any discomfort or pain during gastroscopy (P<0.01). The incidence of cough, restlessness, nausea, vomiting and guttural discomfort in the sedative group was lower than that of the control group. The operative duration was shorter in the sedative group (4.5±1.5) min than in the control group (5.6±1.8) min (P<0.01). The recovery time of the sedative group was (1.4±1.3) min. In the process of inspection, the blood pressure and SaO2 of the patients in the sedative group reduced slightly, but within normal limits. No serious arrhythmia or myocardial ischemia was observed. All the patients went through successfully, leaving no painful memories. Conclusions: Painless gastroscopy is safe for aged patients.
Objective: To investigate the safety and efficacy of painless gastroscopy for aged patients. Methods: One hundred and sixty elderly patients were divided into sedative group (n=160) and control group (n=101). The sedative group received propofol and midazolam intravenously in addition to routine operation. The reaction, operative duration and conscious time were compared between the two groups. The changes of blood pressure, heart rate and blood oxygen saturation (SaO2) before and after operation were recorded and analyzed. Results: 99.4% of the patients in the sedative group and 35% in the control group did not complain of any discomfort or pain during gastroscopy (P<0.01). The incidence of cough, restlessness, nausea, vomiting and guttural discomfort in the sedative group was lower than that of the control group. The operative duration was shorter in the sedative group (4.5±1.5) min than in the control group (5.6±1.8) min (P<0.01). The recovery time of the sedative group was (1.4±1.3) min. In the process of inspection, the blood pressure and SaO2 of the patients in the sedative group reduced slightly, but within normal limits. No serious arrhythmia or myocardial ischemia was observed. All the patients went through successfully, leaving no painful memories. Conclusions: Painless gastroscopy is safe for aged patients.
2007, 32(5): 579-581.
Abstract:
Objective: To describe a modified technique of benign parotid tumors. Methods: Using a face-life incision, the greater auricular nerve was exposed and repaired. According to the position of the tumor, the facial nerve surrounding the branch was selectively retrograded and anatomized, and a partial ectomy of the superficial part of the parotid gland main catheter was performed, keeping the parotid gland. A sternocleidomastoid flap is then transplanted to fill the surgical defect and block the anastomosis between the fibers of the parasympathetic nerve and sympathetic nerve as a mechanical barrier, using the suction drain postoperatively. Results: Thirty-six patients received modified parotidectomy, and all operations were successful. Temporary moderate facial palsy occurred in 5 patients. All patients were followed up for 1-3 years;none of them developed Frey's syndrome or salivary fistula. Further, earlobe sensation recovered completely. The function of the rest of the parotid gland was maintained, and all patients had a satisfactory opinion of their post-operation cosmetic appearance. Conclusions: A modified parotidectomy technique greatly reduces the disadvantages of traditional parotidectomy techniques. A long-term follow-up is needed before the technique can be used as a conventional technique.
Objective: To describe a modified technique of benign parotid tumors. Methods: Using a face-life incision, the greater auricular nerve was exposed and repaired. According to the position of the tumor, the facial nerve surrounding the branch was selectively retrograded and anatomized, and a partial ectomy of the superficial part of the parotid gland main catheter was performed, keeping the parotid gland. A sternocleidomastoid flap is then transplanted to fill the surgical defect and block the anastomosis between the fibers of the parasympathetic nerve and sympathetic nerve as a mechanical barrier, using the suction drain postoperatively. Results: Thirty-six patients received modified parotidectomy, and all operations were successful. Temporary moderate facial palsy occurred in 5 patients. All patients were followed up for 1-3 years;none of them developed Frey's syndrome or salivary fistula. Further, earlobe sensation recovered completely. The function of the rest of the parotid gland was maintained, and all patients had a satisfactory opinion of their post-operation cosmetic appearance. Conclusions: A modified parotidectomy technique greatly reduces the disadvantages of traditional parotidectomy techniques. A long-term follow-up is needed before the technique can be used as a conventional technique.
2007, 32(5): 581-582.
Abstract:
Objective: To investigate the cause of the negative results for exploration of common bile duct in cholecystectomy. Methods: The data from 25 patients with negative results for exploration of common bile duct from June 2000 to December 2005 were analyzed retrospectively. Results: The negative exploration occurred in acute edematous pancreatitis (n=5), chronic pancreatitis (n=4), obstructive cholecystitis (n=6), the petty gallstone (n=6), the muddy gall (n=6) in common bile duct and the tumid lymph gland (n=1) by common bile duct. Conclusions: The causes of the negative results for exploration of common bile duct are various. The negative exploration of common bile duct can be reduced by the intraoperative transcystic duct cholangiography.
Objective: To investigate the cause of the negative results for exploration of common bile duct in cholecystectomy. Methods: The data from 25 patients with negative results for exploration of common bile duct from June 2000 to December 2005 were analyzed retrospectively. Results: The negative exploration occurred in acute edematous pancreatitis (n=5), chronic pancreatitis (n=4), obstructive cholecystitis (n=6), the petty gallstone (n=6), the muddy gall (n=6) in common bile duct and the tumid lymph gland (n=1) by common bile duct. Conclusions: The causes of the negative results for exploration of common bile duct are various. The negative exploration of common bile duct can be reduced by the intraoperative transcystic duct cholangiography.
2007, 32(5): 583-584.
Abstract:
Objective: To observe the causes of hyperbilirubinemia of newborn and to evaluate the clinical effect of medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 on the disease. Methods: Fifty-eight infants with hyperbilirubinemia were randomly divided into two groups:observation group (33 cases) and control group (25 cases). The control group were given luminal and phototherapy, while the observation group were given medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 in addition to the therapy of the control group. The progress of the disease was observed. Results: The response rates were 90.9% and 76.0% in the observation group and the control group respectively. The difference between the two groups was significant (P<0.05). The mean subsiding time for icterus was (4.18±1.41) days and (5.76±3.78) days in observation group and control group respectively (P<0.05);the duration of hospital stay was (8.50±1.52) days and (10.35±2.73) days in observation group and control group respectively (P<0.01). Conclusions: The application of medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 to infants with hyperbilirubinemia can obviously improve the clinical symptom and reduce the hospital stay. It is safe and effective.
Objective: To observe the causes of hyperbilirubinemia of newborn and to evaluate the clinical effect of medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 on the disease. Methods: Fifty-eight infants with hyperbilirubinemia were randomly divided into two groups:observation group (33 cases) and control group (25 cases). The control group were given luminal and phototherapy, while the observation group were given medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 in addition to the therapy of the control group. The progress of the disease was observed. Results: The response rates were 90.9% and 76.0% in the observation group and the control group respectively. The difference between the two groups was significant (P<0.05). The mean subsiding time for icterus was (4.18±1.41) days and (5.76±3.78) days in observation group and control group respectively (P<0.05);the duration of hospital stay was (8.50±1.52) days and (10.35±2.73) days in observation group and control group respectively (P<0.01). Conclusions: The application of medilac-vita combined with ATP, CoA, Vitamin C and Vitamin B6 to infants with hyperbilirubinemia can obviously improve the clinical symptom and reduce the hospital stay. It is safe and effective.
2007, 32(5): 585-586.
Abstract:
Objective: To evaluate the effects of early prophylaxis phototherapy on hyperbilirubinemia in premature infants. Methods: Thirty-nine premature infants who were hospitalized in 24 h (intervention group) were born between Jan 2004 and Dec 2005. All the infants were treated by phototherapy regardless with or without hyperbilirubinemia and the serum bilirubin level was tested and the peak level was compared with the 41 premature infants who were hospitalized in the 24 h (control group) between Nov 2001 to Nov 2003 and were not treated by phototherapy. Results: The morbidity of intervention group and control group was 10.26% and 51.22% respectively with very significant difference (P<0.005). The serum bilirubin peak level in the intervention group (148.1±50.5) μmol/L was significantly lower than in the control group (222.2±62.5) μmol/L with very significant difference (P<0.001). Conclusions: Early prophylaxis phototherapy on 24 h premature infants may prevent hyperbilirubinemia.
Objective: To evaluate the effects of early prophylaxis phototherapy on hyperbilirubinemia in premature infants. Methods: Thirty-nine premature infants who were hospitalized in 24 h (intervention group) were born between Jan 2004 and Dec 2005. All the infants were treated by phototherapy regardless with or without hyperbilirubinemia and the serum bilirubin level was tested and the peak level was compared with the 41 premature infants who were hospitalized in the 24 h (control group) between Nov 2001 to Nov 2003 and were not treated by phototherapy. Results: The morbidity of intervention group and control group was 10.26% and 51.22% respectively with very significant difference (P<0.005). The serum bilirubin peak level in the intervention group (148.1±50.5) μmol/L was significantly lower than in the control group (222.2±62.5) μmol/L with very significant difference (P<0.001). Conclusions: Early prophylaxis phototherapy on 24 h premature infants may prevent hyperbilirubinemia.
2007, 32(5): 587-588.
Abstract:
Objective: To investigate the clinical features and the prognosis of benign infantile convulsions associated with mild gastroenteritis (BICE). Methods: Infants with mild gastroenteritis accompanied with seizures were observed and followed up from November 2001 to October 2006. Results: The ages of onset in 31 cases with mild gastroenteritis accompanied with BICE ranged from 5 to 25 months old, and the prevailing age was between 12 and 24 months old (22 cases). All episodes occurred in winter. The average number of seizures during a single episode was 1.4. The seizure occurred as generalized tonic-clonic pattern. During interval, only one infant presented as active 4-5 Hz θ-wave on electroencephalogram. The brain imaging blood biochemical profile and cerebrospinal fluid testing did not show abnormality in all cases. No antiepileptic medications were prescribed to the patients as the seizures had stopped. One infant experienced relapses that did not happen more than twice. The course of BICE lasted less than one year. All cases demonstrated normal psychomotor development and had no family history of febrile convulsion of epilepsy. Conclusions: The infantile seizures could be associated with mild gastroenteritis, and occur in cases, presenting as temporal episode. The special treatment is not necessary and the prognosis is good.
Objective: To investigate the clinical features and the prognosis of benign infantile convulsions associated with mild gastroenteritis (BICE). Methods: Infants with mild gastroenteritis accompanied with seizures were observed and followed up from November 2001 to October 2006. Results: The ages of onset in 31 cases with mild gastroenteritis accompanied with BICE ranged from 5 to 25 months old, and the prevailing age was between 12 and 24 months old (22 cases). All episodes occurred in winter. The average number of seizures during a single episode was 1.4. The seizure occurred as generalized tonic-clonic pattern. During interval, only one infant presented as active 4-5 Hz θ-wave on electroencephalogram. The brain imaging blood biochemical profile and cerebrospinal fluid testing did not show abnormality in all cases. No antiepileptic medications were prescribed to the patients as the seizures had stopped. One infant experienced relapses that did not happen more than twice. The course of BICE lasted less than one year. All cases demonstrated normal psychomotor development and had no family history of febrile convulsion of epilepsy. Conclusions: The infantile seizures could be associated with mild gastroenteritis, and occur in cases, presenting as temporal episode. The special treatment is not necessary and the prognosis is good.
2007, 32(5): 589-590.
Abstract:
Objective: To explore the clinical manifestations and extrapulmonary complications of Mycoplasma pneumoniae (MP) in children. Methods: The clinical data of 438 cases of children MP were analyzed retrospectively. Results: Three hundred nineteen of all the MP cases were preschool-age children (3-6 years). Among the 153 cases of extrapulmonary complications, 143 cases were no less than 3 years of age and 10 cases were under 3 years. The complications occurred mostly in the circulative system, digestive system and nervous system (51.0%, 29.4% and 17.6%, respectively). All the cases improved after being treated with Azithromycin for 14 days. Assistanted examination showed that the blood MP-IgM in all the cases was ≥ 1:80 and MP culture positive rate was 32.6%. Carinii pneumonia changes was seen in 238 cases, alveolus inflammation in 121 cases and mixed pathological changes in 79 cases. Conclusions: Clinical and chest radiograph examination of MP infection absents speciality and is apt to extrapulmonary complications. If extrapulmonary complication is its first symptom, error diagnosis is commonly inevitable. If the pneumonia presents no ideal treatment changes and is accompanied by extrapulmonary complications, MP infection must be considered. In the same time, related examinations must be conducted to achieve early diagnosis and treatment.
Objective: To explore the clinical manifestations and extrapulmonary complications of Mycoplasma pneumoniae (MP) in children. Methods: The clinical data of 438 cases of children MP were analyzed retrospectively. Results: Three hundred nineteen of all the MP cases were preschool-age children (3-6 years). Among the 153 cases of extrapulmonary complications, 143 cases were no less than 3 years of age and 10 cases were under 3 years. The complications occurred mostly in the circulative system, digestive system and nervous system (51.0%, 29.4% and 17.6%, respectively). All the cases improved after being treated with Azithromycin for 14 days. Assistanted examination showed that the blood MP-IgM in all the cases was ≥ 1:80 and MP culture positive rate was 32.6%. Carinii pneumonia changes was seen in 238 cases, alveolus inflammation in 121 cases and mixed pathological changes in 79 cases. Conclusions: Clinical and chest radiograph examination of MP infection absents speciality and is apt to extrapulmonary complications. If extrapulmonary complication is its first symptom, error diagnosis is commonly inevitable. If the pneumonia presents no ideal treatment changes and is accompanied by extrapulmonary complications, MP infection must be considered. In the same time, related examinations must be conducted to achieve early diagnosis and treatment.
2007, 32(5): 591-592.
Abstract:
Objective: To investigate the curative effect of naloxone in treatment of neonates with middle or severe hypoxic-ischemic encephalopathy (HIE). Methods: Based on the traditional therapy, naloxone was added to treat 20 neonates with middle or severe HIE and compared the curative effect with 12 controls. The indexes included vital signs, resumption time of consciousness, reflex and muscular tension, sustaining time of main symptoms and signs, and curative outcome. Results: Compared with controls, patients treated with naloxone showed better vital signs, their resumption time of consciousness and muscular tension were shoter, as well as their sustaining time of main symptoms and signs. Total effective rate of management group was higher than control group (P=0.030). Conclusions: Naloxone plays an important role in treating neonates with middle or severe HIE, elevates curative effect and has no side effects.
Objective: To investigate the curative effect of naloxone in treatment of neonates with middle or severe hypoxic-ischemic encephalopathy (HIE). Methods: Based on the traditional therapy, naloxone was added to treat 20 neonates with middle or severe HIE and compared the curative effect with 12 controls. The indexes included vital signs, resumption time of consciousness, reflex and muscular tension, sustaining time of main symptoms and signs, and curative outcome. Results: Compared with controls, patients treated with naloxone showed better vital signs, their resumption time of consciousness and muscular tension were shoter, as well as their sustaining time of main symptoms and signs. Total effective rate of management group was higher than control group (P=0.030). Conclusions: Naloxone plays an important role in treating neonates with middle or severe HIE, elevates curative effect and has no side effects.
2007, 32(5): 593-594.
Abstract:
Objective: To study the efficiency of intravenous immunoglobulin (IVIG) on infants with severe pneumonia. Methods: Fifty-four children with severe pneumonia were administered different therapies. Twenty-six children received large dose of IVIG (1 g·kg-1·d-1) daily in addition to routine treatment for 2 days, while other 28 children in the control group received only routine treatment. Results: Dyspnea was the most common symptom in infants with severe pneumonia. The symptom in the therapy group improved more rapidly than that in the control group. The difference was significant (P<0.001). Conclusions: IVIG can decrease the symptom and increase the cure rate in infants with severe pneumonia.
Objective: To study the efficiency of intravenous immunoglobulin (IVIG) on infants with severe pneumonia. Methods: Fifty-four children with severe pneumonia were administered different therapies. Twenty-six children received large dose of IVIG (1 g·kg-1·d-1) daily in addition to routine treatment for 2 days, while other 28 children in the control group received only routine treatment. Results: Dyspnea was the most common symptom in infants with severe pneumonia. The symptom in the therapy group improved more rapidly than that in the control group. The difference was significant (P<0.001). Conclusions: IVIG can decrease the symptom and increase the cure rate in infants with severe pneumonia.
2007, 32(5): 607-608.
Abstract:
Objective: To improve diagnosis and differential diagnosis of the ectopic pregnancy. Methods: The uterus and paramerium were examined by trans-abdomen sonography and transvaginal sonography. The analysis was conducted with clinical data. Results: Forty-one of 50 patients were diagnosed as ectopic pregnancy, including one with belly cavity gestation, one with cornual pregnancy and 7 with misdiagnosis. The diagnosis for these patients was confirmed by operation and pathology. Conclusions: Ultrasonic plays an important role in the early diagnosis and differential diagnosis of ectopic pregnancy.
Objective: To improve diagnosis and differential diagnosis of the ectopic pregnancy. Methods: The uterus and paramerium were examined by trans-abdomen sonography and transvaginal sonography. The analysis was conducted with clinical data. Results: Forty-one of 50 patients were diagnosed as ectopic pregnancy, including one with belly cavity gestation, one with cornual pregnancy and 7 with misdiagnosis. The diagnosis for these patients was confirmed by operation and pathology. Conclusions: Ultrasonic plays an important role in the early diagnosis and differential diagnosis of ectopic pregnancy.
2007, 32(5): 609-611.
Abstract:
Objective: To improve the molybdenum target radiologic diagnosis rate of breast cancer. Methods: The X-ray findings of 27 patients with breast cancer confirmed by operation and pathology were analyzed. Results: Among 27 patients, lump in 22 patients, calcifications in 13, focal architecture distortion in 5, skin and nipple change in 3, the asymmetrical dilated vessel in 2 and armpit lymphadenovarix in 2 were found. Conclusions: The molybdenum target radiography is very valuable for the diagnosis of breast cancer. More attention should be paid to its application in the field of differential diagnosis.
Objective: To improve the molybdenum target radiologic diagnosis rate of breast cancer. Methods: The X-ray findings of 27 patients with breast cancer confirmed by operation and pathology were analyzed. Results: Among 27 patients, lump in 22 patients, calcifications in 13, focal architecture distortion in 5, skin and nipple change in 3, the asymmetrical dilated vessel in 2 and armpit lymphadenovarix in 2 were found. Conclusions: The molybdenum target radiography is very valuable for the diagnosis of breast cancer. More attention should be paid to its application in the field of differential diagnosis.
2007, 32(5): 611-613.
Abstract:
Objective: To explore and evaluate the comparability and bias of the testing results of blood urea nitrogen (BUN), creatinine (Cr), glucose (GLU) and uric acid (UA) derived from three different biochemical analysis systems in three hospitals and to validate whether mutual accredit of these testing results can be performed among these hospitals. Methods: According to the document of NCCLS EP9-A, 5-7 clinic samples were detected in three kinds of different biochemical analysis systems (Beckman CX4, Olympus 2700 and Hitachi 7600) respectively everyday. The testing results of total 41 samples were recorded within 7 days and those of 40 samples were kept after one outlier value was deleted. The testing results derived from three biochemical analysis systems were analyzed comparatively and their bias was evaluated by biochemical analysis in Beckman CX4 as a control method and biochemical analyses in Olympus 2700 and Hitachi 7600 as experimental methods. Results: Both correlation (r2>0.95) and linear regression between the testing results of BUN, Cr, GLU and UA in three different biochemical analysis systems in three hospitals were good. Their anticipated biases (but with exception for Cr when its testing result was within the normal reference range) were within allowed biases. Conclusions: On the basis of good internal quality control and external quality assessment, the testing results of BUN, Cr, GLU and UA derived from three different biochemical analysis systems from the three hospitals can be mutually accredited.
Objective: To explore and evaluate the comparability and bias of the testing results of blood urea nitrogen (BUN), creatinine (Cr), glucose (GLU) and uric acid (UA) derived from three different biochemical analysis systems in three hospitals and to validate whether mutual accredit of these testing results can be performed among these hospitals. Methods: According to the document of NCCLS EP9-A, 5-7 clinic samples were detected in three kinds of different biochemical analysis systems (Beckman CX4, Olympus 2700 and Hitachi 7600) respectively everyday. The testing results of total 41 samples were recorded within 7 days and those of 40 samples were kept after one outlier value was deleted. The testing results derived from three biochemical analysis systems were analyzed comparatively and their bias was evaluated by biochemical analysis in Beckman CX4 as a control method and biochemical analyses in Olympus 2700 and Hitachi 7600 as experimental methods. Results: Both correlation (r2>0.95) and linear regression between the testing results of BUN, Cr, GLU and UA in three different biochemical analysis systems in three hospitals were good. Their anticipated biases (but with exception for Cr when its testing result was within the normal reference range) were within allowed biases. Conclusions: On the basis of good internal quality control and external quality assessment, the testing results of BUN, Cr, GLU and UA derived from three different biochemical analysis systems from the three hospitals can be mutually accredited.
2007, 32(5): 614-615.
Abstract:
Objective: To investigate the serum levels of high sensitivity C reactive protein (h-CRP), total bilirubin (TBil) and direct bilirubin (DBil) in patients with coronary arteriosclerosis and the correlation between their levels and arteriosclerosis. Methods: The levels of h-CRP was determined by latex-enhanced immunoturbidimetric, DBil and TBil were determined by continuous monitoring assay in 48 patients with coronary arteriosclerosis and 50 controls. Results: Compared with the control, the levels of h-CRP, DBil and TBil in these patients had statistically significant differences. The levels of h-CRP of these patients were higher than those of the control (P<0.001) while the levels of DBil and TBil were lower (P<0.001). Conclusions: The determination of the levels of hs-CRP, DBil and TBil in serum can help in evaluating the severity and the risk of coronary arteriosclerosis, which will prevent coronary artery disease.
Objective: To investigate the serum levels of high sensitivity C reactive protein (h-CRP), total bilirubin (TBil) and direct bilirubin (DBil) in patients with coronary arteriosclerosis and the correlation between their levels and arteriosclerosis. Methods: The levels of h-CRP was determined by latex-enhanced immunoturbidimetric, DBil and TBil were determined by continuous monitoring assay in 48 patients with coronary arteriosclerosis and 50 controls. Results: Compared with the control, the levels of h-CRP, DBil and TBil in these patients had statistically significant differences. The levels of h-CRP of these patients were higher than those of the control (P<0.001) while the levels of DBil and TBil were lower (P<0.001). Conclusions: The determination of the levels of hs-CRP, DBil and TBil in serum can help in evaluating the severity and the risk of coronary arteriosclerosis, which will prevent coronary artery disease.
2007, 32(5): 618-620.
Abstract:
Objective: To study the clinical application value and nursing point of transfusion pump in chemotherapy for multiple myeloma. Methods: Twenty-three patients with multiple myeloma were final diagnosis, 11 patients were distributed into treatment group and others were control group randomly. Infusion pump was adopted in treatment group, while common transfusion was used to control group. All treatment projects were VAD. Results: Twenty-six and 29 courses of chemotherapy were undertaken in treatment group and control group respectively. The incidence rates of phlebophlogosis, skin destruction, nausea and vomiting, dental ulcer and costiveness in treatment group were lower than those in control group, the difference were significance (P<0.05-P<0.01). Conclusions: The method of administer drags has the characteristics of persistent rate and quanitity, dose stability in unit time and adver-se reaction little, it is good method for its safety credibility, simpleness efficianey and time-saving.
Objective: To study the clinical application value and nursing point of transfusion pump in chemotherapy for multiple myeloma. Methods: Twenty-three patients with multiple myeloma were final diagnosis, 11 patients were distributed into treatment group and others were control group randomly. Infusion pump was adopted in treatment group, while common transfusion was used to control group. All treatment projects were VAD. Results: Twenty-six and 29 courses of chemotherapy were undertaken in treatment group and control group respectively. The incidence rates of phlebophlogosis, skin destruction, nausea and vomiting, dental ulcer and costiveness in treatment group were lower than those in control group, the difference were significance (P<0.05-P<0.01). Conclusions: The method of administer drags has the characteristics of persistent rate and quanitity, dose stability in unit time and adver-se reaction little, it is good method for its safety credibility, simpleness efficianey and time-saving.
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