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2007 Vol. 32, No. 6
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2007, 32(6): 631-632,636.
Abstract:
Objective: To observe the selective alterations of endogenous pituitary adenylate cyclase-activating polypeptide(PACAP) and PAC1 receptor gene expression in PC12 cells induced by neurotoxin-Rotenone and neuropeptide-PACAP.Methods: Real-time polymerase chain reaction(RT-PCR) was performed to examine alterations of endogenous PACAP and PAC1 receptor gene expression in PC12 cells.Results: Our data demonstrated that rotenone significantly increased gene expression of endogenous PACAP and PAC1 receptor and only neuropeptide PACAP27 have no effects on the gene expressions of endogenous PACAP and PAC1 receptor;In base of rotenone-treatment,PACAP in presence of PAC1 antianognist,PACAP6-27 or without presence of it,promote increasing of PACAP expressions(P<0.01).Conclusions: Our study indicates that Our results indicated that Endogenous PACAP was shown to contribute to self-defense and compensatory mechanisms by regulating PACAP expression itself.
Objective: To observe the selective alterations of endogenous pituitary adenylate cyclase-activating polypeptide(PACAP) and PAC1 receptor gene expression in PC12 cells induced by neurotoxin-Rotenone and neuropeptide-PACAP.Methods: Real-time polymerase chain reaction(RT-PCR) was performed to examine alterations of endogenous PACAP and PAC1 receptor gene expression in PC12 cells.Results: Our data demonstrated that rotenone significantly increased gene expression of endogenous PACAP and PAC1 receptor and only neuropeptide PACAP27 have no effects on the gene expressions of endogenous PACAP and PAC1 receptor;In base of rotenone-treatment,PACAP in presence of PAC1 antianognist,PACAP6-27 or without presence of it,promote increasing of PACAP expressions(P<0.01).Conclusions: Our study indicates that Our results indicated that Endogenous PACAP was shown to contribute to self-defense and compensatory mechanisms by regulating PACAP expression itself.
2007, 32(6): 633-636,765.
Abstract:
Objective: To observe the antineoplastic action of aspisol on transplanted tumors of C3H mice and the influence of aspisol on hematopoietic organs,hepatic function and renal function of mice.Tumor cell apoptosis had also been determined for providing experiment bases of aspisol in breast cancer therapy.Methods: The suspension of cells was injected subcutaneously into forelimb axillas of C3H mice.From the next day,the explanted animals were received different concentration of aspisol by intraperitoneally once a day for 28 days.The reference group was given 5-Fu and control group was given normal saline.At 30th day after treatment,the mice were sacrificed,tumor weight were examined,haemocyte number were calculated,hepatic function and renal function were detected.The histopathological change were observed microscopically,TUNEL assay in situ were performed for determine the apoptosis.Results: aspisol can inhibit the growth of tumor significantly,the tumor volume were dramatically reduced(P<0.01).Histological examination results showed apparent necrosis in aspisol group.Typical apoptotic morphological changes were seen in all the treated groups.aspisol didn't affect hematopoietic organs,hepatic function and renal function of the tumor bearing animals at certain time or dosage.Conclusions: aspisol has significantly antitumor effects on C3H mice transplantable breast cancer,can induce tumor cell apoptosis,without obvious influence on hematopoietic system,hepatic function and renal function.
Objective: To observe the antineoplastic action of aspisol on transplanted tumors of C3H mice and the influence of aspisol on hematopoietic organs,hepatic function and renal function of mice.Tumor cell apoptosis had also been determined for providing experiment bases of aspisol in breast cancer therapy.Methods: The suspension of cells was injected subcutaneously into forelimb axillas of C3H mice.From the next day,the explanted animals were received different concentration of aspisol by intraperitoneally once a day for 28 days.The reference group was given 5-Fu and control group was given normal saline.At 30th day after treatment,the mice were sacrificed,tumor weight were examined,haemocyte number were calculated,hepatic function and renal function were detected.The histopathological change were observed microscopically,TUNEL assay in situ were performed for determine the apoptosis.Results: aspisol can inhibit the growth of tumor significantly,the tumor volume were dramatically reduced(P<0.01).Histological examination results showed apparent necrosis in aspisol group.Typical apoptotic morphological changes were seen in all the treated groups.aspisol didn't affect hematopoietic organs,hepatic function and renal function of the tumor bearing animals at certain time or dosage.Conclusions: aspisol has significantly antitumor effects on C3H mice transplantable breast cancer,can induce tumor cell apoptosis,without obvious influence on hematopoietic system,hepatic function and renal function.
2007, 32(6): 637-639,765.
Abstract:
Objective: To explore the protective effect of curcumin(Cur) on the injury caused by focal cerebral ischemia/reperfusion(I/R) of rats and its mechanism.Methods: The model of middle cerebral artery occlusion(MCAO) and reperfusion was set up.Cur of 20 mg/kg,40 mg/kg and 60 mg/kg was intraperitoneally injected into the rats respectively,and the changes of the neurologic deficiency scores and the infarct volume were observed.The expression of HSP70 in brain tissue was detected by the method of immuno-histochemistry.Results: Sham-operated group presented no neurologic changes.The neurologic deficiency scores in Cur groups were obviously elevated,compared with those in I/R group.The infarct volume in Cur groups was obviously less than that of I/R group,and the infarct volume of Cur 20 mg/kg group was obviously larger than that of the other two groups.Compared with I/R group,the number and the rate of HSP70 positive cells increased obviously in Cur groups,and Cur 40 mg/kg group was supior to the other two groups.Conclusions: Cur can prevent rats from focal cerebral ischemia/reperfusion damage.The mechanism may be that Cur can elevate the expression of HSP70 in local cerebral ischemia/reperfusion damage,thus protecting the neurons more effectively.
Objective: To explore the protective effect of curcumin(Cur) on the injury caused by focal cerebral ischemia/reperfusion(I/R) of rats and its mechanism.Methods: The model of middle cerebral artery occlusion(MCAO) and reperfusion was set up.Cur of 20 mg/kg,40 mg/kg and 60 mg/kg was intraperitoneally injected into the rats respectively,and the changes of the neurologic deficiency scores and the infarct volume were observed.The expression of HSP70 in brain tissue was detected by the method of immuno-histochemistry.Results: Sham-operated group presented no neurologic changes.The neurologic deficiency scores in Cur groups were obviously elevated,compared with those in I/R group.The infarct volume in Cur groups was obviously less than that of I/R group,and the infarct volume of Cur 20 mg/kg group was obviously larger than that of the other two groups.Compared with I/R group,the number and the rate of HSP70 positive cells increased obviously in Cur groups,and Cur 40 mg/kg group was supior to the other two groups.Conclusions: Cur can prevent rats from focal cerebral ischemia/reperfusion damage.The mechanism may be that Cur can elevate the expression of HSP70 in local cerebral ischemia/reperfusion damage,thus protecting the neurons more effectively.
2007, 32(6): 640-642.
Abstract:
Objective: To investigate the mechanisms of multidrug resistance in human lung adenocarcinoma cell line A549/ADM and the reversion of multidrug resistance with rifamycin.Methods: The expressions of P-glycoprotein(P-gp) and multidrug resistance-associated protein(MRP) were detected with flow cytometry.The resistance to chemotherapeutic drugs and the reversion with rifamycin was evaluated with MTT assay.The accumulation of ADM in A549/ADM cells was evaluated with flow cytometry.Results: The expression of P-gp and MRP enhanced significantly(74.8% and 61.2%) compared with A549 cells;with rifamycin(8 μg/ml)added,the sensitivity of A549/ADM cells to ADM raised by 2.51 times and accumulation of ADM in A549/ADM cells was significantly increased.The sensitivity to VCR,DDP and VP-16 increased by 7.38,1.29 and 2.86 times respecitively.Conclusions: A549/ADM cells are resistant to many commonly used anti-cancer chemotherapeutic drugs and the resistance might be related to P-gp and MRP overexpression.Rifamycin could reverse the MDR of lung adenocarcinoma cell lines A549/ADM.
Objective: To investigate the mechanisms of multidrug resistance in human lung adenocarcinoma cell line A549/ADM and the reversion of multidrug resistance with rifamycin.Methods: The expressions of P-glycoprotein(P-gp) and multidrug resistance-associated protein(MRP) were detected with flow cytometry.The resistance to chemotherapeutic drugs and the reversion with rifamycin was evaluated with MTT assay.The accumulation of ADM in A549/ADM cells was evaluated with flow cytometry.Results: The expression of P-gp and MRP enhanced significantly(74.8% and 61.2%) compared with A549 cells;with rifamycin(8 μg/ml)added,the sensitivity of A549/ADM cells to ADM raised by 2.51 times and accumulation of ADM in A549/ADM cells was significantly increased.The sensitivity to VCR,DDP and VP-16 increased by 7.38,1.29 and 2.86 times respecitively.Conclusions: A549/ADM cells are resistant to many commonly used anti-cancer chemotherapeutic drugs and the resistance might be related to P-gp and MRP overexpression.Rifamycin could reverse the MDR of lung adenocarcinoma cell lines A549/ADM.
2007, 32(6): 643-645,765.
Abstract:
Objective: To study the expression of Fas and Fas-L proteins in rat liver fibrosis model and the role of IFN-γ.Methods: Liver fibrosis was successfully induced in rats by subcutaneous injection of carbon tetrachloride(CCl4).The rats were divided into fibrosis model group and IFN-γ treatment group(20 mu·kg-1·d-1,intramuscular injection for 12 weeks)and the group of rats without treatment was used as normal control.Fas and Fas-L proteins of the three groups were detected by immunohistochemistry.Results: Fas and Fas-L proteins were scarcely detected in the plasma of hepatocytes in the normal control,but they cound be found in the fibrous septae and hepatic sinusoid in fibrosis model rats(P<0.01).Compared with that in fibrosis models,the expression of Fas and Fas-L protein was significantly lower in rats treated with IFN-γ(P<0.05-P<0.01).Conclusions: The expression of Fas and Fas-L proteins is increased in rat liver fibrosis model.IFN-γ can inhibit the expression of Fas and Fas-L.
Objective: To study the expression of Fas and Fas-L proteins in rat liver fibrosis model and the role of IFN-γ.Methods: Liver fibrosis was successfully induced in rats by subcutaneous injection of carbon tetrachloride(CCl4).The rats were divided into fibrosis model group and IFN-γ treatment group(20 mu·kg-1·d-1,intramuscular injection for 12 weeks)and the group of rats without treatment was used as normal control.Fas and Fas-L proteins of the three groups were detected by immunohistochemistry.Results: Fas and Fas-L proteins were scarcely detected in the plasma of hepatocytes in the normal control,but they cound be found in the fibrous septae and hepatic sinusoid in fibrosis model rats(P<0.01).Compared with that in fibrosis models,the expression of Fas and Fas-L protein was significantly lower in rats treated with IFN-γ(P<0.05-P<0.01).Conclusions: The expression of Fas and Fas-L proteins is increased in rat liver fibrosis model.IFN-γ can inhibit the expression of Fas and Fas-L.
2007, 32(6): 645-646.
Abstract:
Objective: To summarize the clinical experience of auricular reconstruction for microtia or atia.Methods: Thirty-six micratia or atia patients(two of the patients had bilateral defects) wese reconstructed consecutively using tissue expansion method and the three-dimensional ear framework fabricated with sculpted rib cartilage.Some patients were followed up.Results: Thirty-eight ears were reconstructed in 36 patients.The final results were promising and most patients showed consistently favorable aesthetic results.Reconstructed auricule apparently grew in childhood.Otocranial angle showed 30° to 45° steadily.Conclusions: Tissue expansion method for auricular reconstruction is one of excellent methods.
Objective: To summarize the clinical experience of auricular reconstruction for microtia or atia.Methods: Thirty-six micratia or atia patients(two of the patients had bilateral defects) wese reconstructed consecutively using tissue expansion method and the three-dimensional ear framework fabricated with sculpted rib cartilage.Some patients were followed up.Results: Thirty-eight ears were reconstructed in 36 patients.The final results were promising and most patients showed consistently favorable aesthetic results.Reconstructed auricule apparently grew in childhood.Otocranial angle showed 30° to 45° steadily.Conclusions: Tissue expansion method for auricular reconstruction is one of excellent methods.
2007, 32(6): 647-649.
Abstract:
Objective: To detect expression of human papillomavirus(HPV) type 16 and 18 in carcinoma tissues and peripheral blood of patients with cervical carcinomas,and to explore the relationship between HPV infection and cervical carcinomas,as well as its expression in tumour micrometastase.Methods: Real-time fluorescence quantitative PCR(FQ-PCR) and reverse transcription polymerase chain reaction(RT-PCR) were used to detect HPV in 24 cases of tissues and 48 samples of peripheral blood of cervical carcinomas,and 20 cases of tissues and 20 smples of peripheral blood of chronic cervicitis.Results: In the 24 tissues of cervical carcinomas(Ⅰ-Ⅱb),the positive rate of HPV DNA type 16 was 66.7%;the positive rate of HPV DNA type 18 was 29.2%;the positive rate of both positive HPV DNA 16 and HPV DNA 18 was 8.0%.In the 48 samples of peripheral blood cervical carcinomas,the positive rate of HPV mRNA type 16 was 2.1%.In the 20 chronic cervicitis tissues,the positive rate of HPV DNA type 16 was 15.0% and HPV DNA type 18 was negative.Both HPV type 16 and 18 of peripheral blood were negative.The difference was markedly significant between cervical carcinomas and chronic cervicitis(P<0.005-P<0.05).Conclusions: The quantitation of HPV is highly associated with cervical carcinomas.Detection of HPV mRNA in the peripheral blood of cervical carcinomas is low,and its clinical significance needs further evaluation.
Objective: To detect expression of human papillomavirus(HPV) type 16 and 18 in carcinoma tissues and peripheral blood of patients with cervical carcinomas,and to explore the relationship between HPV infection and cervical carcinomas,as well as its expression in tumour micrometastase.Methods: Real-time fluorescence quantitative PCR(FQ-PCR) and reverse transcription polymerase chain reaction(RT-PCR) were used to detect HPV in 24 cases of tissues and 48 samples of peripheral blood of cervical carcinomas,and 20 cases of tissues and 20 smples of peripheral blood of chronic cervicitis.Results: In the 24 tissues of cervical carcinomas(Ⅰ-Ⅱb),the positive rate of HPV DNA type 16 was 66.7%;the positive rate of HPV DNA type 18 was 29.2%;the positive rate of both positive HPV DNA 16 and HPV DNA 18 was 8.0%.In the 48 samples of peripheral blood cervical carcinomas,the positive rate of HPV mRNA type 16 was 2.1%.In the 20 chronic cervicitis tissues,the positive rate of HPV DNA type 16 was 15.0% and HPV DNA type 18 was negative.Both HPV type 16 and 18 of peripheral blood were negative.The difference was markedly significant between cervical carcinomas and chronic cervicitis(P<0.005-P<0.05).Conclusions: The quantitation of HPV is highly associated with cervical carcinomas.Detection of HPV mRNA in the peripheral blood of cervical carcinomas is low,and its clinical significance needs further evaluation.
2007, 32(6): 649-651,766.
Abstract:
Objective: To explore the value of the expression of survivin gene in auxiliary diagnosis of gastric cancer.Methods: The gastric carcinoma tissues and the neighboring noncancerous tissues of 49 cases with histologically verified gastric carcinoma were obtained.The survivin mRNA level was measued by RT-PCR and the protein expression of survivin was detected by immunohistochemical assay.Results: Survivin mRNA proved positive in 65.3%(32 cases)of the gastric cancerous tissues and 63.3%(31cases)of the protein respectively.In contrast,no expression of survivin was detected in the corresponding noncancerous tissues.The expression of survivin gene detected by RT-PCR was a bit higher than IHC,with no statistical significance(P>0.05).Conclusions: The expression of survivin in gastric cancerous tissues is up-regulated.Detection of survivin gene by immunohistochemistry or RT-PCR would be a new method in diagnosis of gastric cancer.
Objective: To explore the value of the expression of survivin gene in auxiliary diagnosis of gastric cancer.Methods: The gastric carcinoma tissues and the neighboring noncancerous tissues of 49 cases with histologically verified gastric carcinoma were obtained.The survivin mRNA level was measued by RT-PCR and the protein expression of survivin was detected by immunohistochemical assay.Results: Survivin mRNA proved positive in 65.3%(32 cases)of the gastric cancerous tissues and 63.3%(31cases)of the protein respectively.In contrast,no expression of survivin was detected in the corresponding noncancerous tissues.The expression of survivin gene detected by RT-PCR was a bit higher than IHC,with no statistical significance(P>0.05).Conclusions: The expression of survivin in gastric cancerous tissues is up-regulated.Detection of survivin gene by immunohistochemistry or RT-PCR would be a new method in diagnosis of gastric cancer.
2007, 32(6): 652-653,656.
Abstract:
Objective: To study the relationship between cerebrovascular accident complication and plasma high-sensitivity C-reactive protein(Hs-CRP) level in patients with chronic renal failure.Methods: Twenty-eight cases of chronic renal failure with cerebrovascular accident complication(groupA) and 32 cases without cerebrovascular accident complication(group B)were detected of the levels of plasma Hs-CRP,age,plasma triglyceride(TG),total cholesterol(CHO),high-density lipoprotein cholesterol(HDL),serum creatinine(Scr),plasma albumin(ALB)and blood urea nitrogen(BUN).The results were compared with those of 30 healthy ontrols(group C).Results: The level of plasma Hs-CRP in group A and group B was significantly increased compaired with that of group C(P<0.01).The level of plasma Hs-CPR in group A was significantly increased compared with that of group B and the difference was great(P<0.01).The level of Hs-CRP was apparently affected by plasma triglycericle TG,CHO,HDL,Scr,ALB and BUN,but had no relations with age(P>0.05).Conclusions: The Hs-CRP level is high in patients with chronic renal failure accompanied by cerebrovascular accident complication.Observation of Hs-CRP level is essential to predict the occurrence of cerebrovascular accident complicatio in patients with chronic renal failure.
Objective: To study the relationship between cerebrovascular accident complication and plasma high-sensitivity C-reactive protein(Hs-CRP) level in patients with chronic renal failure.Methods: Twenty-eight cases of chronic renal failure with cerebrovascular accident complication(groupA) and 32 cases without cerebrovascular accident complication(group B)were detected of the levels of plasma Hs-CRP,age,plasma triglyceride(TG),total cholesterol(CHO),high-density lipoprotein cholesterol(HDL),serum creatinine(Scr),plasma albumin(ALB)and blood urea nitrogen(BUN).The results were compared with those of 30 healthy ontrols(group C).Results: The level of plasma Hs-CRP in group A and group B was significantly increased compaired with that of group C(P<0.01).The level of plasma Hs-CPR in group A was significantly increased compared with that of group B and the difference was great(P<0.01).The level of Hs-CRP was apparently affected by plasma triglycericle TG,CHO,HDL,Scr,ALB and BUN,but had no relations with age(P>0.05).Conclusions: The Hs-CRP level is high in patients with chronic renal failure accompanied by cerebrovascular accident complication.Observation of Hs-CRP level is essential to predict the occurrence of cerebrovascular accident complicatio in patients with chronic renal failure.
2007, 32(6): 654-656.
Abstract:
Objective: To evaluate the clinical efficacy of three different operative patterns of hysterectomy including laparoscopic hysterectomy(LH),trans-abdominal hysterectomy(TAH) and trans-vaginal hysterectomy(TVH).Methods: A retrospective analysis on 404 patients undergoing hysterectomy was carried out including the operating time,the bleed volume,the complications and the postoperative recovery.Results: The operating time,the bleed volume and hospitalized time in TAH group were longer and greater than those in LH group and TVH group(P<0.01).The operating time was also longer in LH group than in TVH group(P<0.01).It could be found that there was significant difference in surgical complications among the three groups(P<0.05).All patients recovered well postoperatively.Conclusions: The three operative patterns are ideal for hysterectomy.Optimal choice for patients to undergo hysterectomy should depend on idiographic clinic circumstance such as patient condition and preference,the gynaecological surgeon's skills and so on.
Objective: To evaluate the clinical efficacy of three different operative patterns of hysterectomy including laparoscopic hysterectomy(LH),trans-abdominal hysterectomy(TAH) and trans-vaginal hysterectomy(TVH).Methods: A retrospective analysis on 404 patients undergoing hysterectomy was carried out including the operating time,the bleed volume,the complications and the postoperative recovery.Results: The operating time,the bleed volume and hospitalized time in TAH group were longer and greater than those in LH group and TVH group(P<0.01).The operating time was also longer in LH group than in TVH group(P<0.01).It could be found that there was significant difference in surgical complications among the three groups(P<0.05).All patients recovered well postoperatively.Conclusions: The three operative patterns are ideal for hysterectomy.Optimal choice for patients to undergo hysterectomy should depend on idiographic clinic circumstance such as patient condition and preference,the gynaecological surgeon's skills and so on.
2007, 32(6): 657-659.
Abstract:
Objective: To study the relationship between myeloperoxidase-463 G/A genetic polymorphism(MPO)and coronary heart disease(CHD).Methods: A case-control study was performed in 60 CHD patients proved by angiography and 69 controls with no history of CHD or stroke.PCR-RFLP methods were used to decide the genotype of the patients,and the statistical analysis was carried out.Results: The risk of CHD in the genotype carrying at least one A allele was 0.208 times that of the GG genotype;the risk of CHD in the genotype carrying A allele was 0.229 times that of carrying G allele.Conclusions: Myeloperoxidase-463G/A polymorphism of the MPO gene influences the risk of CHD.And A allele has protective effect on the occurrence of CHD.
Objective: To study the relationship between myeloperoxidase-463 G/A genetic polymorphism(MPO)and coronary heart disease(CHD).Methods: A case-control study was performed in 60 CHD patients proved by angiography and 69 controls with no history of CHD or stroke.PCR-RFLP methods were used to decide the genotype of the patients,and the statistical analysis was carried out.Results: The risk of CHD in the genotype carrying at least one A allele was 0.208 times that of the GG genotype;the risk of CHD in the genotype carrying A allele was 0.229 times that of carrying G allele.Conclusions: Myeloperoxidase-463G/A polymorphism of the MPO gene influences the risk of CHD.And A allele has protective effect on the occurrence of CHD.
2007, 32(6): 660-661.
Abstract:
Objective: To evaluated the values of both the total mesorectal excision(TME) and the double stapling technique in rectal carcinoma.Methods: Thirty-three patients with rectal carcinoma undergoing rectectomy with this technique were reviewed.Results: The anastomotic leakage occurred in 1 patient,and anastomotic stricture occurred in 2 cases in this group.All patients were followed up for 1 year to 5 years,and local recurrence occurred in 2 patients in this group.The rate of 3-year survival was 80%.Conclusions: Application of TME and the double stapling technique in anus preservation of rectal carcinoma can decrease the rate of local recurrence.It is safe,reliable and effective.
Objective: To evaluated the values of both the total mesorectal excision(TME) and the double stapling technique in rectal carcinoma.Methods: Thirty-three patients with rectal carcinoma undergoing rectectomy with this technique were reviewed.Results: The anastomotic leakage occurred in 1 patient,and anastomotic stricture occurred in 2 cases in this group.All patients were followed up for 1 year to 5 years,and local recurrence occurred in 2 patients in this group.The rate of 3-year survival was 80%.Conclusions: Application of TME and the double stapling technique in anus preservation of rectal carcinoma can decrease the rate of local recurrence.It is safe,reliable and effective.
2007, 32(6): 662-664,765.
Abstract:
Objective: To investigate the expressions of S100A4 protein in oral squamous cell carcinoma(OSCC) and its significance.Methods: Expression of S100A4 protein was detected by using immunohistochemistry SP method in 61 patients with OSCC and 20 cases of normal mucosa.Relationship between the expression of S100A4 protein and clinicopathological features was analyzed.Results: The positive expression rate of S100A4 protein was 24.6% in OSCC,but negative expression in NOM.The difference in the positive expression rate of S100A4 protein was statistically significant between the OSCC and NOM(P<0.05).Expression of S100A4 protein in OSCC had positive correlation with lymph node metastasis(P<0.01),and no correlation with histological grading(P>0.05).Conclusions: S100A4 protein is related with invasion and metastasis of OSCC.Expression of S100A4 protein is significantly associated with tumor progression in OSCC,which was one of the valuable markers for predicting biological behavior and trend of metastasis of OSCC.
Objective: To investigate the expressions of S100A4 protein in oral squamous cell carcinoma(OSCC) and its significance.Methods: Expression of S100A4 protein was detected by using immunohistochemistry SP method in 61 patients with OSCC and 20 cases of normal mucosa.Relationship between the expression of S100A4 protein and clinicopathological features was analyzed.Results: The positive expression rate of S100A4 protein was 24.6% in OSCC,but negative expression in NOM.The difference in the positive expression rate of S100A4 protein was statistically significant between the OSCC and NOM(P<0.05).Expression of S100A4 protein in OSCC had positive correlation with lymph node metastasis(P<0.01),and no correlation with histological grading(P>0.05).Conclusions: S100A4 protein is related with invasion and metastasis of OSCC.Expression of S100A4 protein is significantly associated with tumor progression in OSCC,which was one of the valuable markers for predicting biological behavior and trend of metastasis of OSCC.
2007, 32(6): 664-665.
Abstract:
Objective: To evaluate the effect of limbus cornea stem cell autograft transplantation with fresh amnion in treatment of recurrent pterygium.Methods: Thirty patients with recurrent pterygium were treated.Complications and pterygium recurrence were analyzed.Patients were followed for at least 1 year.Results: The treatment was significantly effective and no recurrent pterygium occurred.Conclusions: Limbus cornea stem cell autograft transplantation with fresh amnion is a safe and effective method.
Objective: To evaluate the effect of limbus cornea stem cell autograft transplantation with fresh amnion in treatment of recurrent pterygium.Methods: Thirty patients with recurrent pterygium were treated.Complications and pterygium recurrence were analyzed.Patients were followed for at least 1 year.Results: The treatment was significantly effective and no recurrent pterygium occurred.Conclusions: Limbus cornea stem cell autograft transplantation with fresh amnion is a safe and effective method.
2007, 32(6): 666-668.
Abstract:
Objective: To investigate the expression and clinical significance of matrix metalloproteinase-2(MMP-2) and carcino embryonic antigen(CEA) in patients with gastric carcinoma.Methods: Bioptic and resectic specimens were examined by S-P immunohistochemical method for MMP-2;the content of serum CEA was detected by immunoradicmetricassay,and their relations with the differentiation degree of gastric carcinoma,TNM stage,lymph node metastasis,liver metastasis,pancreas metastasis,degree of peritoneum and vascular system invovlement were analyzed.Results: Expression of CEA was positively related to the lymph node metastasis,liver metastasis and peritoneum metastasis(P<0.01-P<0.005),but was not related to the differentiation of gastric carcinoma,pancreas metastasis,vascular system metastasis or TNM stage(P>0.05).Expression of MMP-2 protein was positively related to the lymph node metastasis,liver metastasis,pancreas metastasis,vascular system metastasis and peritoneum metastasis(P<0.005),but was not related to the differentiation degree of gastric carcinoma or TNM stage(P>0.05).Conclusions: CEA and MMP-2 may play an important role in the formation,invasion and metastasis of gastric carcinoma.Expression of them might serve as an objective indicator for estimating tumor pregress and predicting the metastasis of cancer cells.
Objective: To investigate the expression and clinical significance of matrix metalloproteinase-2(MMP-2) and carcino embryonic antigen(CEA) in patients with gastric carcinoma.Methods: Bioptic and resectic specimens were examined by S-P immunohistochemical method for MMP-2;the content of serum CEA was detected by immunoradicmetricassay,and their relations with the differentiation degree of gastric carcinoma,TNM stage,lymph node metastasis,liver metastasis,pancreas metastasis,degree of peritoneum and vascular system invovlement were analyzed.Results: Expression of CEA was positively related to the lymph node metastasis,liver metastasis and peritoneum metastasis(P<0.01-P<0.005),but was not related to the differentiation of gastric carcinoma,pancreas metastasis,vascular system metastasis or TNM stage(P>0.05).Expression of MMP-2 protein was positively related to the lymph node metastasis,liver metastasis,pancreas metastasis,vascular system metastasis and peritoneum metastasis(P<0.005),but was not related to the differentiation degree of gastric carcinoma or TNM stage(P>0.05).Conclusions: CEA and MMP-2 may play an important role in the formation,invasion and metastasis of gastric carcinoma.Expression of them might serve as an objective indicator for estimating tumor pregress and predicting the metastasis of cancer cells.
2007, 32(6): 669-670.
Abstract:
Objective: To assess the analgesic and side effects of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl.Methods: Eighty grade Ⅰ-Ⅱ ASA patients of radical mastectomy were randomly divided into two groups:group L(n=40)received post operative intravenous analgesia with lornoxican and fentanyl while group T(n=40) received postoperative intravenous analgesia with tramadol.In group L,lornoxican 56 mg,fentanyl 0.3 mg and granisetron 3 mg were diluted with normal saline to 100 ml while in group T tramadol 800 mg and Granisetron 3 mg were diluted with normal saline to 100 ml.The patients received a loading dose,Group L:lornoxican 8 mg;group T:tramadol 100 mg,before suturing skin and then received the analgesia pump.Pain score(VAS 0-10),sedation score(0-3) and side effects were recorded at 4 h,8 h,12 h,24 h and 48 h after operation.Results: There was no significant difference in pain and sedation scores between the two groups(P>0.05).The incidence of side effects in Tramadol group was higher than that in lornoxican and fentanyl group(P<0.01-P<0.05).Conclusions: lornoxican and fentanyl are safe and effective in the treatment of postoperative pain of radical mastectomy,and have fewer side effects than Tramadol.
Objective: To assess the analgesic and side effects of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl.Methods: Eighty grade Ⅰ-Ⅱ ASA patients of radical mastectomy were randomly divided into two groups:group L(n=40)received post operative intravenous analgesia with lornoxican and fentanyl while group T(n=40) received postoperative intravenous analgesia with tramadol.In group L,lornoxican 56 mg,fentanyl 0.3 mg and granisetron 3 mg were diluted with normal saline to 100 ml while in group T tramadol 800 mg and Granisetron 3 mg were diluted with normal saline to 100 ml.The patients received a loading dose,Group L:lornoxican 8 mg;group T:tramadol 100 mg,before suturing skin and then received the analgesia pump.Pain score(VAS 0-10),sedation score(0-3) and side effects were recorded at 4 h,8 h,12 h,24 h and 48 h after operation.Results: There was no significant difference in pain and sedation scores between the two groups(P>0.05).The incidence of side effects in Tramadol group was higher than that in lornoxican and fentanyl group(P<0.01-P<0.05).Conclusions: lornoxican and fentanyl are safe and effective in the treatment of postoperative pain of radical mastectomy,and have fewer side effects than Tramadol.
2007, 32(6): 671-673.
Abstract:
Objective: To explore the characteristics,related factors and prognosis of poststroke depression(PSD).Methods: One hundred and ninety-two patients with cerebral stroke were investigated by sefl-rating depression scale(SDS) and Hamilton rating scall for depression(HAMD) about the occurrence of PSD and the clinical characteristics.Results: The occurrence rate of PSD was 37.5%.Among them,light deppression accounted for 20.8%,medium deppression 10.4% and heavy deppression 6.3%.The PSD was closely related to the damage situs and the degree of cerebral stroke.Conclusions: PSD is a familiar complication after cerebral stroke.It is closely related to the damage of nerve function and the patients' ability of daily living.Application of antidepressant agents in early treatment can improve the patients' life quality and recovery of nerve function.
Objective: To explore the characteristics,related factors and prognosis of poststroke depression(PSD).Methods: One hundred and ninety-two patients with cerebral stroke were investigated by sefl-rating depression scale(SDS) and Hamilton rating scall for depression(HAMD) about the occurrence of PSD and the clinical characteristics.Results: The occurrence rate of PSD was 37.5%.Among them,light deppression accounted for 20.8%,medium deppression 10.4% and heavy deppression 6.3%.The PSD was closely related to the damage situs and the degree of cerebral stroke.Conclusions: PSD is a familiar complication after cerebral stroke.It is closely related to the damage of nerve function and the patients' ability of daily living.Application of antidepressant agents in early treatment can improve the patients' life quality and recovery of nerve function.
2007, 32(6): 673-674.
Abstract:
Objective: To explore the characteristics of bone metastasis and to investigate the diagnostic value of radionuclide bone imaging in patients with lung cancer.Methods: Bone metastatic sites,quantity and different pathological types were analyzed retrospectively in 113 cases of skeletal metastases patients with lung cancer in past three years.Results: Among the 113 patients,62.8% patients were multiple bone metastasis.Most metastatic sites were in spine,and others were in rib,pelvis,and skull.Conclusions: Multiple bone metastasis is one of the characters of lung cancer.The thorax and thoracic spine is the most frequent metastatic sites.Bone metastasis of squamous carcinoma was more easily than other types of lung cancer.Radionuclide bone scan is the most sensitive method for the diagnosis of osseous metastasis.All the patients with lung cancer should be performed radionuclide bone scan,which is significant for staging,selecting therapy methods and the evaluating prognosis of the disease.
Objective: To explore the characteristics of bone metastasis and to investigate the diagnostic value of radionuclide bone imaging in patients with lung cancer.Methods: Bone metastatic sites,quantity and different pathological types were analyzed retrospectively in 113 cases of skeletal metastases patients with lung cancer in past three years.Results: Among the 113 patients,62.8% patients were multiple bone metastasis.Most metastatic sites were in spine,and others were in rib,pelvis,and skull.Conclusions: Multiple bone metastasis is one of the characters of lung cancer.The thorax and thoracic spine is the most frequent metastatic sites.Bone metastasis of squamous carcinoma was more easily than other types of lung cancer.Radionuclide bone scan is the most sensitive method for the diagnosis of osseous metastasis.All the patients with lung cancer should be performed radionuclide bone scan,which is significant for staging,selecting therapy methods and the evaluating prognosis of the disease.
2007, 32(6): 675-677.
Abstract:
Objective: To observe the relations between intima media thickness(IMT) of common carotid and coronary heart disease in elderly patients with type 2 diabetes mellitus.Methods: One hundrend and twenty-four type 2 diabetes mellitus patients with coronary heart diseases including 60 cases of SAP and 64 cases of UAP(group A),58 patients without coronary heart diseases as manifested by CAG(group B) and 133 healthy subjects were enrolled in our study.The IMT of the 3 groups was observed with high resolution ultrasound,and the levels of blood pressure,plasma glucose and blood lipids were measured as well.The factors affecting IMT were analyzed.Results: The IMT in the 3 groups was statistically different(P<0.01).Gensini and IMT in both UAP and SAP groups had no statistical differences(P>0.05).The rate of unstable carotid plaque of all patients in UAP group was higher than that in SAP group(P<0.0167)Conclusions: Ultrasonography could determine the IMT of carotid and carotid plaque,so it is of great value in predicting coronary heart diseases in type-2 diabetes mellitus patients.
Objective: To observe the relations between intima media thickness(IMT) of common carotid and coronary heart disease in elderly patients with type 2 diabetes mellitus.Methods: One hundrend and twenty-four type 2 diabetes mellitus patients with coronary heart diseases including 60 cases of SAP and 64 cases of UAP(group A),58 patients without coronary heart diseases as manifested by CAG(group B) and 133 healthy subjects were enrolled in our study.The IMT of the 3 groups was observed with high resolution ultrasound,and the levels of blood pressure,plasma glucose and blood lipids were measured as well.The factors affecting IMT were analyzed.Results: The IMT in the 3 groups was statistically different(P<0.01).Gensini and IMT in both UAP and SAP groups had no statistical differences(P>0.05).The rate of unstable carotid plaque of all patients in UAP group was higher than that in SAP group(P<0.0167)Conclusions: Ultrasonography could determine the IMT of carotid and carotid plaque,so it is of great value in predicting coronary heart diseases in type-2 diabetes mellitus patients.
2007, 32(6): 678-680.
Abstract:
Objective: To explore an appropriate procedure for treatment of acute perforation of gastric cancer.Methods: Twenty-four cases of perforated gastric cancer were included in the study.Among them,5 were in TNM stage Ⅱ,14 in stage Ⅲ and 5 in stage Ⅳ.Five cases were treated with repair of perforation(3 cases received simple repair of perforation,2 cases repair and gastrojejunestomy),11 cases with partial gastrectomy and great omentectomy,and 8 cases with radical resection(6 with clearance of lymph nodes in D1 and 2 with clearance in D2).Results: Twenty-three cases were cured and 1 case died.The median survival time of the patients treated with the 3 procedures was 5.6,15.2 and 28.2 months,respectively.Conclusions: Radical resection with D1 resection is the appropriate operative procedure for treatment of acute perforation of gastric cancer.For those who could not receceive radical resection,palliative resection is suggested.
Objective: To explore an appropriate procedure for treatment of acute perforation of gastric cancer.Methods: Twenty-four cases of perforated gastric cancer were included in the study.Among them,5 were in TNM stage Ⅱ,14 in stage Ⅲ and 5 in stage Ⅳ.Five cases were treated with repair of perforation(3 cases received simple repair of perforation,2 cases repair and gastrojejunestomy),11 cases with partial gastrectomy and great omentectomy,and 8 cases with radical resection(6 with clearance of lymph nodes in D1 and 2 with clearance in D2).Results: Twenty-three cases were cured and 1 case died.The median survival time of the patients treated with the 3 procedures was 5.6,15.2 and 28.2 months,respectively.Conclusions: Radical resection with D1 resection is the appropriate operative procedure for treatment of acute perforation of gastric cancer.For those who could not receceive radical resection,palliative resection is suggested.
2007, 32(6): 680-681.
Abstract:
Objective: To study the relationship of gallstone to insulin resistance(IR) and lipid level in type 2 diabetes mellitus.Methods: A case matched study was carried out to investigate the changes of C-peptide,serum lipids in type 2 diabetic patients with or without gallstone.Results: The rate of C-peptide,lipoprotein and cholestrol were much higher than those of the patients without gallstone.The other indexes had no statistical difference(P<0.05-P<0.001).Conclusions: The result indicates that IR and dyslipoidosis might be an independence risk factor for the development of gallstone in type 2 diabetic patients.
Objective: To study the relationship of gallstone to insulin resistance(IR) and lipid level in type 2 diabetes mellitus.Methods: A case matched study was carried out to investigate the changes of C-peptide,serum lipids in type 2 diabetic patients with or without gallstone.Results: The rate of C-peptide,lipoprotein and cholestrol were much higher than those of the patients without gallstone.The other indexes had no statistical difference(P<0.05-P<0.001).Conclusions: The result indicates that IR and dyslipoidosis might be an independence risk factor for the development of gallstone in type 2 diabetic patients.
2007, 32(6): 682-683,766.
Abstract:
Objective: To observe the distribution of interstitial cells of Cajal(ICCs) in Hirschsprung disease(HD),and investigate the role of ICCs in HD.Methods: The distribution of ICCs was examined in 32 patients with HD and 10 normal controls by PV immunohistochemistry.Results: In bowels from normal controls and ganglionic segment from HD,the moderate to large amount of ICCs were observed around the myenteric plexus and at the circular muscle layer.ICCs in these domain appeared as a network structure.On the contrary,the number of ICCs was significantly decreased or even disappeared in between the muscle layers of the ganglionic segment in HD.Conclusions: Abnormal distribution of ICCs in the bowel affected by HD may explain the bowel dysmotility seen in these patients.
Objective: To observe the distribution of interstitial cells of Cajal(ICCs) in Hirschsprung disease(HD),and investigate the role of ICCs in HD.Methods: The distribution of ICCs was examined in 32 patients with HD and 10 normal controls by PV immunohistochemistry.Results: In bowels from normal controls and ganglionic segment from HD,the moderate to large amount of ICCs were observed around the myenteric plexus and at the circular muscle layer.ICCs in these domain appeared as a network structure.On the contrary,the number of ICCs was significantly decreased or even disappeared in between the muscle layers of the ganglionic segment in HD.Conclusions: Abnormal distribution of ICCs in the bowel affected by HD may explain the bowel dysmotility seen in these patients.
2007, 32(6): 684-685.
Abstract:
Objective: To explore the causes and preventive measures for neonatal unconjugated hyperbilirubinemia.Methods: The causes of neonatal unconjugated hyperbilirubinemia in 77 newborns(51 male and 26 female) were analyzed.Active treatments were given according to the causes.Results: The causes of neonatal unconjugated hyperbilirubinemia included infectious factors(58.24%),perinatal factors(26.37%),breast-feeding jaundice(12.09%) and hemolytic disease of the newborn(3.30%).The infectious factors were the most common causes for unconjugated hyperbilirubinemia in the newborns.However,several causes leading to hyperbilirubinemia might exist in the same newborn.In this study,16.88% cases of hyperbilirubinemia were induced by more than one causes.Prognosis is good.Among the 77 cases,64 cases were cured,12 cases improved,and 1 case was given up.Conclusions: In order to reduce the incidence of neonatal unconjugated hyperbilirubinemia,more emphasis should be put on the health care of the perinatal period.
Objective: To explore the causes and preventive measures for neonatal unconjugated hyperbilirubinemia.Methods: The causes of neonatal unconjugated hyperbilirubinemia in 77 newborns(51 male and 26 female) were analyzed.Active treatments were given according to the causes.Results: The causes of neonatal unconjugated hyperbilirubinemia included infectious factors(58.24%),perinatal factors(26.37%),breast-feeding jaundice(12.09%) and hemolytic disease of the newborn(3.30%).The infectious factors were the most common causes for unconjugated hyperbilirubinemia in the newborns.However,several causes leading to hyperbilirubinemia might exist in the same newborn.In this study,16.88% cases of hyperbilirubinemia were induced by more than one causes.Prognosis is good.Among the 77 cases,64 cases were cured,12 cases improved,and 1 case was given up.Conclusions: In order to reduce the incidence of neonatal unconjugated hyperbilirubinemia,more emphasis should be put on the health care of the perinatal period.
2007, 32(6): 686-687.
Abstract:
Objective: To study the parameter features of lung function in children with chronic cough and its clinical value.Methods: Sixty-eight children(under 6 years of age) with chronic cough including 33 cases of non-asthma and 35 cases of variant asthma(CVA)were detected of the tidal breathing pulmonary function,and the result was compared with that of other 38 cases of typical asthma.Results: There was no difference between non-asthma group and CVA group in the following parameters:tidal volume(VT),rate of respiratory(RR) and time of expiration(TE)(P>0.05);meanwhile,the time of inspiration(TI),time of inspiration/time of expiration(TI/TE),time to peak expiratory flow/time of expiration(TPF/TE),and volume of peak expiratory flow/volume of expiration(VPF/VE) demonstrated significant difference(P<0.05) between the two groups.TPF/TE and VPF/VE in the non-asthma group was obviously higher than that in the CVA group and the other parameters had no statistical significance(P>0.05).Ratio of TI/TE in CVA group was higher than that in typical asthma group(P<0.05),but the difference was not significant between them with other parameters(P>0.05).Conclusions: Lung function test has great value in distinguishing patients with chronic cough with non-asthma and those with cough variant asthma,which may provide clinical basis for the treatment of the disesase.
Objective: To study the parameter features of lung function in children with chronic cough and its clinical value.Methods: Sixty-eight children(under 6 years of age) with chronic cough including 33 cases of non-asthma and 35 cases of variant asthma(CVA)were detected of the tidal breathing pulmonary function,and the result was compared with that of other 38 cases of typical asthma.Results: There was no difference between non-asthma group and CVA group in the following parameters:tidal volume(VT),rate of respiratory(RR) and time of expiration(TE)(P>0.05);meanwhile,the time of inspiration(TI),time of inspiration/time of expiration(TI/TE),time to peak expiratory flow/time of expiration(TPF/TE),and volume of peak expiratory flow/volume of expiration(VPF/VE) demonstrated significant difference(P<0.05) between the two groups.TPF/TE and VPF/VE in the non-asthma group was obviously higher than that in the CVA group and the other parameters had no statistical significance(P>0.05).Ratio of TI/TE in CVA group was higher than that in typical asthma group(P<0.05),but the difference was not significant between them with other parameters(P>0.05).Conclusions: Lung function test has great value in distinguishing patients with chronic cough with non-asthma and those with cough variant asthma,which may provide clinical basis for the treatment of the disesase.
2007, 32(6): 688-690.
Abstract:
Objective: To study the role of β-glucuronidase(β-GD) in breast-milk jaundice in neonates and its diagnostic vaule.Methods: The study was conducted on 60 neonates with breast-milk jaundic(study group) and 70 healthy newborns(control group).The β-GD activity and the serum total bilirubin concentration was estimated in the breast milk and the infants' feces at day 7,14,21 and day 28.The positive rates of β-GD activity in the breast-milk jaundic were determined at the same time points.Results: The difference of β-GD activities in the study group and the control group had statistical significance(P<0.001).The infant fecal β-GD activities at each time point was obviously different between the two groups(P<0.001).The serum total bilirubin levels had positive correlation to the β-GD activities both in breast milk and infant faces in the study group and the correlation coefficients were 0.785 and 0.753,respectively(P<0.01).The positive rates of milk β-GD in infants with breast milk jaundice and healthy newbrons were 80.0% and 7.1% respectively.The difference was significant(P<0.005).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 80.0%,92.9%,90.6%,84.4%,and 86.9%,respectively.The positive rates of fecal β-GD measurement in babies with breast-milk jaundice and healthy newbrons were 78.3% and 5.7% respectively.The difference was significant(P<0.005).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 78.3%,94.3%,92.2%,83.5% and 86.9%,respectively.Conclusions: β-GD activity plays an important role in breast-milk jaundice in neonates.The measurement of β-GD in breast-milk and infants'feces is of value for diagnosis of breast-milk jaundice.
Objective: To study the role of β-glucuronidase(β-GD) in breast-milk jaundice in neonates and its diagnostic vaule.Methods: The study was conducted on 60 neonates with breast-milk jaundic(study group) and 70 healthy newborns(control group).The β-GD activity and the serum total bilirubin concentration was estimated in the breast milk and the infants' feces at day 7,14,21 and day 28.The positive rates of β-GD activity in the breast-milk jaundic were determined at the same time points.Results: The difference of β-GD activities in the study group and the control group had statistical significance(P<0.001).The infant fecal β-GD activities at each time point was obviously different between the two groups(P<0.001).The serum total bilirubin levels had positive correlation to the β-GD activities both in breast milk and infant faces in the study group and the correlation coefficients were 0.785 and 0.753,respectively(P<0.01).The positive rates of milk β-GD in infants with breast milk jaundice and healthy newbrons were 80.0% and 7.1% respectively.The difference was significant(P<0.005).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 80.0%,92.9%,90.6%,84.4%,and 86.9%,respectively.The positive rates of fecal β-GD measurement in babies with breast-milk jaundice and healthy newbrons were 78.3% and 5.7% respectively.The difference was significant(P<0.005).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 78.3%,94.3%,92.2%,83.5% and 86.9%,respectively.Conclusions: β-GD activity plays an important role in breast-milk jaundice in neonates.The measurement of β-GD in breast-milk and infants'feces is of value for diagnosis of breast-milk jaundice.
Realization of diagnosis and treatment of primary liver cancer with cancer thrombus of the bile duct
2007, 32(6): 691-692.
Abstract:
Objective: To evaluate surgical therapy and the effect of hepatectomy plus the clearance of tumor thrombi from bile in the bile duct for primary hepatocellular carcinoma(PLC) with tumorbi in the bile duct.Methods: Nine Patients with PLC and bile duct thrombi(BDT) who underwent surgical intervention were retrospectively analyzed.Results: There was no operative mortality and all patients were followed up for 3-15 months.Two patients were died for a relapse of hepatoma,and seven still alive.Conclusions: Hepatectomy plus the clearance of tumor thrombi from bile duct was effective for treatment of patients with PLC and BDT.
Objective: To evaluate surgical therapy and the effect of hepatectomy plus the clearance of tumor thrombi from bile in the bile duct for primary hepatocellular carcinoma(PLC) with tumorbi in the bile duct.Methods: Nine Patients with PLC and bile duct thrombi(BDT) who underwent surgical intervention were retrospectively analyzed.Results: There was no operative mortality and all patients were followed up for 3-15 months.Two patients were died for a relapse of hepatoma,and seven still alive.Conclusions: Hepatectomy plus the clearance of tumor thrombi from bile duct was effective for treatment of patients with PLC and BDT.
2007, 32(6): 693-695.
Abstract:
Objective: To investigate the influential factors of feeding intolerance in premature infant and to find strategies for the prevention of feeding intolerance.Methods: The relationships among feeding intolerance and birth weight,gestation,and timing of feeding initiation of about 130 premature infant in our hospital from January 2005 to July 2006 were analyzed retrospectively.Results: The total rate of feeding intolerance in premature infant was 30 percent.There was no significant difference found between birth weights of ≤ 1 500 g and >1 500 g(P>0.05).Further,there was no significant difference found between gestation periods of ≤ 34 and >34 weeks,although for ≤ 36 a difference was found(P>0.05).As for the timing of feeding initiation,a significant difference was found between times of >2 days and ≤ 2 days(P<0.05).Asphyxia,other complications,and gestational disease in the mother were not associated with feeding intolerance.Conclusions: Feeding intolerance occurs more easily in neonates with later feeding initiation.The early right feeding can reduce the premature infant dependence of parenteral natrintion and improve the living quality of the premature infant.
Objective: To investigate the influential factors of feeding intolerance in premature infant and to find strategies for the prevention of feeding intolerance.Methods: The relationships among feeding intolerance and birth weight,gestation,and timing of feeding initiation of about 130 premature infant in our hospital from January 2005 to July 2006 were analyzed retrospectively.Results: The total rate of feeding intolerance in premature infant was 30 percent.There was no significant difference found between birth weights of ≤ 1 500 g and >1 500 g(P>0.05).Further,there was no significant difference found between gestation periods of ≤ 34 and >34 weeks,although for ≤ 36 a difference was found(P>0.05).As for the timing of feeding initiation,a significant difference was found between times of >2 days and ≤ 2 days(P<0.05).Asphyxia,other complications,and gestational disease in the mother were not associated with feeding intolerance.Conclusions: Feeding intolerance occurs more easily in neonates with later feeding initiation.The early right feeding can reduce the premature infant dependence of parenteral natrintion and improve the living quality of the premature infant.
2007, 32(6): 695-696.
Abstract:
Objective: To compare one-man method and two-men method in the operation of colonoscopy,and to assess its clinical value.Methods: Nine hundred ninety two cases examined with two-men method and 1 451 cases with one-man method were analyzed and the results were compared in terms of successful rate,operation duration,the rate of abdominal pain and the occurrence of enterobrosis.Results: The successful rates of one-man method and two-men method were 96.4% and 90.8%(P<0.005),respectively;the operation durations of that were(18.4±6.9) minutes and(26.6±8.3) minutes(P<0.001),respectively;the rates of serious abdominal pain of that were 1.0% and 6.7%(P<0.005),respectively;and the rate of enterobrosis were 0 and 0.3%(P>0.05),respectively.Conclusions: Compared with two-man method,one-man method is easier to operate and has a higher successful rate,shorter duration and a lower rate of serious abdominal pain.Therefore one-man method is worth popularizing and should gradually replace two-man method in colonoscopy.
Objective: To compare one-man method and two-men method in the operation of colonoscopy,and to assess its clinical value.Methods: Nine hundred ninety two cases examined with two-men method and 1 451 cases with one-man method were analyzed and the results were compared in terms of successful rate,operation duration,the rate of abdominal pain and the occurrence of enterobrosis.Results: The successful rates of one-man method and two-men method were 96.4% and 90.8%(P<0.005),respectively;the operation durations of that were(18.4±6.9) minutes and(26.6±8.3) minutes(P<0.001),respectively;the rates of serious abdominal pain of that were 1.0% and 6.7%(P<0.005),respectively;and the rate of enterobrosis were 0 and 0.3%(P>0.05),respectively.Conclusions: Compared with two-man method,one-man method is easier to operate and has a higher successful rate,shorter duration and a lower rate of serious abdominal pain.Therefore one-man method is worth popularizing and should gradually replace two-man method in colonoscopy.
2007, 32(6): 697-699.
Abstract:
Objective: To explore the etiology,diagnosis and treatment of functional delayed gastric emptying(FDGE) after non-gastric operation.Methods: The clinical data of 7 patients with FDGE from May 2000 to December 2005 were analyzed retrospectively.Results: FDGE usually occurred on the 4th to 8th day postoperatively.The gastric function of patients who received non-operative therapy recovered on the 15th to 24th day postoperatively.Conclusions: FDGE is caused by multiple factors.Gastroscopy and X-ray of digestive tract are valuable in the diagnosis of it.FDGE can be cured by non-surgical treatment.
Objective: To explore the etiology,diagnosis and treatment of functional delayed gastric emptying(FDGE) after non-gastric operation.Methods: The clinical data of 7 patients with FDGE from May 2000 to December 2005 were analyzed retrospectively.Results: FDGE usually occurred on the 4th to 8th day postoperatively.The gastric function of patients who received non-operative therapy recovered on the 15th to 24th day postoperatively.Conclusions: FDGE is caused by multiple factors.Gastroscopy and X-ray of digestive tract are valuable in the diagnosis of it.FDGE can be cured by non-surgical treatment.
2007, 32(6): 699-700.
Abstract:
Objective: To investigate the hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp.Methods: The data of hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp in 33 patients were retrospectively analyzed.Results: Thirty-three patients received the operation successfully without complications and with little bleeding.Conclusions: The hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp is safe and effective with less bleeding and postoperative pain,and shorter hospitalization time.
Objective: To investigate the hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp.Methods: The data of hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp in 33 patients were retrospectively analyzed.Results: Thirty-three patients received the operation successfully without complications and with little bleeding.Conclusions: The hysteroscopic treatment of the submucous myoma of uterus and the cervical polyp is safe and effective with less bleeding and postoperative pain,and shorter hospitalization time.
2007, 32(6): 701-703.
Abstract:
Objective: To evaluate the curative and cost efficacy of inhalational therapy for asthma in children.Methods: A questionnaire survey was conducted in 702 asthma children(including cough variability asthma) with an age of 1-14 years.Results: After inhalational therapy,the children's daytime symptom,night symptom and peak value expiration velocity of flow(PEF) improved significantly(P<0.001).The acute spasm extent of asthma decreased and their quality of life improved significantly(P<0.005).At the same time,the cost for tremtment decreased greatly(P<0.001).Conclusions: The inhalational therapy for asthma could improve the patients' clinical symptom,improve their quality of life and relieve the family of the cost burden.
Objective: To evaluate the curative and cost efficacy of inhalational therapy for asthma in children.Methods: A questionnaire survey was conducted in 702 asthma children(including cough variability asthma) with an age of 1-14 years.Results: After inhalational therapy,the children's daytime symptom,night symptom and peak value expiration velocity of flow(PEF) improved significantly(P<0.001).The acute spasm extent of asthma decreased and their quality of life improved significantly(P<0.005).At the same time,the cost for tremtment decreased greatly(P<0.001).Conclusions: The inhalational therapy for asthma could improve the patients' clinical symptom,improve their quality of life and relieve the family of the cost burden.
2007, 32(6): 703-704.
Abstract:
Objective: To explore the causes of chronic cough in children.Methods: The causes of chronic cough in 60 children were analyzed.Results: Among the 60 cases of chronic cough in children,emycoplasma pneumoniae infection accounted for 24 cases,cough variant asthma 20 cases,tuberculosis 9 cases,postnasal drip syndrome 7 cases,foreign body in trachea 3 cases and gastroesophageal reflux 2 cases.Single cause was found in 55 cases and double causes were found in 5 cases.Conclusions: The main causes of chronic cough in children were mycoplasma pneumoniae infection,cough variant asthma,tuberculosis and postnasal drip syndrome.
Objective: To explore the causes of chronic cough in children.Methods: The causes of chronic cough in 60 children were analyzed.Results: Among the 60 cases of chronic cough in children,emycoplasma pneumoniae infection accounted for 24 cases,cough variant asthma 20 cases,tuberculosis 9 cases,postnasal drip syndrome 7 cases,foreign body in trachea 3 cases and gastroesophageal reflux 2 cases.Single cause was found in 55 cases and double causes were found in 5 cases.Conclusions: The main causes of chronic cough in children were mycoplasma pneumoniae infection,cough variant asthma,tuberculosis and postnasal drip syndrome.
2007, 32(6): 705-705,708.
Abstract:
Objective: To observe the effect of CT-guided puncturing and injecting absolute alcohol for treatment of huge hepatic cysts.Methods: Eight patients with huge hepatic cysts were treated by puncturing and injecting absolute alcohol for 10 times with the aid of CT.Results: The clinical symptoms of all the 8 cases were obviously alleviated.The cysts were deflated gradually in 8 cases and closed up completely in 2 cases.No serious side effects were observed by type-B ultrasonic or CT examination.Conclusions: Treatment of huge hepatic cysts by CT-guided puncturing and injecting absolute alcohol is effective.It has the advantages of small lesion,little side effect and easy operation.
Objective: To observe the effect of CT-guided puncturing and injecting absolute alcohol for treatment of huge hepatic cysts.Methods: Eight patients with huge hepatic cysts were treated by puncturing and injecting absolute alcohol for 10 times with the aid of CT.Results: The clinical symptoms of all the 8 cases were obviously alleviated.The cysts were deflated gradually in 8 cases and closed up completely in 2 cases.No serious side effects were observed by type-B ultrasonic or CT examination.Conclusions: Treatment of huge hepatic cysts by CT-guided puncturing and injecting absolute alcohol is effective.It has the advantages of small lesion,little side effect and easy operation.
2007, 32(6): 706-708.
Abstract:
Objective: To summarize the experience in diagnosis and treatment of penetrating cardic trauma(PCT).Methods: A retrospec-tive study was carried out in 11 PCT patients treated with surgical approaches from December 1995 to December 2005.Pericardiopuncture was performed in 10 patients with a deep venous puncture needle,and 9 cases obtained positive results;a central venous catheter was put in the pericardial cavity of the patients for decompression drainage.All the patients received surgical treatment.Ten patients were operated on in the operating room and one in the emergency room.In this study,anteriolateral thoracotomy was performed in 10 cases and midsternal thoracotomy in one.Results: All the patients were cured,leaving no complications.Conclusions: Early diagnosis is the precondition of successful treatment.Diagnosis is made according to the wound of chest wall and clinical manifestation.Pericardiopuncture can not only confirme the diagnosis,but also win time for the surgery before operation.Emergency thoracotomy is essential for patients with PCT,and the operative approach is based on the site and size of the wound of heart.
Objective: To summarize the experience in diagnosis and treatment of penetrating cardic trauma(PCT).Methods: A retrospec-tive study was carried out in 11 PCT patients treated with surgical approaches from December 1995 to December 2005.Pericardiopuncture was performed in 10 patients with a deep venous puncture needle,and 9 cases obtained positive results;a central venous catheter was put in the pericardial cavity of the patients for decompression drainage.All the patients received surgical treatment.Ten patients were operated on in the operating room and one in the emergency room.In this study,anteriolateral thoracotomy was performed in 10 cases and midsternal thoracotomy in one.Results: All the patients were cured,leaving no complications.Conclusions: Early diagnosis is the precondition of successful treatment.Diagnosis is made according to the wound of chest wall and clinical manifestation.Pericardiopuncture can not only confirme the diagnosis,but also win time for the surgery before operation.Emergency thoracotomy is essential for patients with PCT,and the operative approach is based on the site and size of the wound of heart.
2007, 32(6): 709-710.
Abstract:
Objective: To investigate the reasonableness of diagnosis and treatment of deep venous thrombosis after operation on iliac-rector carcinoma.Methods: The thrombosis limb was given cold compress and elevation 15°-30°.The thrombosis limb was given hot compress and anticoagulant therapy at 72 h after cold compress.Results: Eight of 12 patients with legs edema were cured during the two weeks.Two months later,by colour doppler examination all the patients were recovered.Conclusions: The preventive measures should be taken before and after operation.The thrombolysis and low-dose anticoagulant are effective in treatment of the malignant venous embolus good and the recurrence rate is very low.
Objective: To investigate the reasonableness of diagnosis and treatment of deep venous thrombosis after operation on iliac-rector carcinoma.Methods: The thrombosis limb was given cold compress and elevation 15°-30°.The thrombosis limb was given hot compress and anticoagulant therapy at 72 h after cold compress.Results: Eight of 12 patients with legs edema were cured during the two weeks.Two months later,by colour doppler examination all the patients were recovered.Conclusions: The preventive measures should be taken before and after operation.The thrombolysis and low-dose anticoagulant are effective in treatment of the malignant venous embolus good and the recurrence rate is very low.
2007, 32(6): 711-712.
Abstract:
Objective: To explore the appropriate time and procedure for treatment of intra-articular calcaneal fracture with plastic titanic alloy plate.Methods: Twenty-eight cases(30 feet) of calcaneal fracture of type Ⅱ,type Ⅲ and type Ⅳ were treated by by open reduction and internal fixation of plastic titanic alloy plate.Results: All the 28 cases(30 feet) were followed up for 6 to 32 months.According to Marryland foot score system,the foot function was excellent in 21 feet,good in 7 feet and fair in 2 feet,with a total excellent and good rate of 93.3%.Conclusions: Open reduction and internal fixation with plastic titanic alloy plate is an effective procedeure for treatment of inra-articular calcaneal fracture.
Objective: To explore the appropriate time and procedure for treatment of intra-articular calcaneal fracture with plastic titanic alloy plate.Methods: Twenty-eight cases(30 feet) of calcaneal fracture of type Ⅱ,type Ⅲ and type Ⅳ were treated by by open reduction and internal fixation of plastic titanic alloy plate.Results: All the 28 cases(30 feet) were followed up for 6 to 32 months.According to Marryland foot score system,the foot function was excellent in 21 feet,good in 7 feet and fair in 2 feet,with a total excellent and good rate of 93.3%.Conclusions: Open reduction and internal fixation with plastic titanic alloy plate is an effective procedeure for treatment of inra-articular calcaneal fracture.
2007, 32(6): 713-714.
Abstract:
Objective: To investigate the cause and the prevention of anastomotic stoma fistula after total mesorectal excision for low rectal cancer.Methods: The results of surgery for distal rectal cancer with total mesorectal excision(TME) were reviewed.Results: Totally 315 patients underwent low anterior resection with TME in our hospital from 2002 to 2006.Seventeen of 315 patients treated by resection and anastomosis developed a clinically significant anastomotic leakage.The fistula healing time was(24.2±11.3) days.Two patients who were managed operatively were cured.Fifteen patients were managed conservatively.Thirteen of 15 were cured while the other both died.Conclusions: The incidence of anastomotic leakage is relatively low.There are many causes leading to the anastomotic fistulas which include operative capacity,preoperative preparation and total immunutrion and drainage.
Objective: To investigate the cause and the prevention of anastomotic stoma fistula after total mesorectal excision for low rectal cancer.Methods: The results of surgery for distal rectal cancer with total mesorectal excision(TME) were reviewed.Results: Totally 315 patients underwent low anterior resection with TME in our hospital from 2002 to 2006.Seventeen of 315 patients treated by resection and anastomosis developed a clinically significant anastomotic leakage.The fistula healing time was(24.2±11.3) days.Two patients who were managed operatively were cured.Fifteen patients were managed conservatively.Thirteen of 15 were cured while the other both died.Conclusions: The incidence of anastomotic leakage is relatively low.There are many causes leading to the anastomotic fistulas which include operative capacity,preoperative preparation and total immunutrion and drainage.
2007, 32(6): 715-717.
Abstract:
Objective: To assess the value of urinary pyridol(uPyd),urinary deoxypyridinoline(uDpd) and urinary N terminal telopeptide opeptide(uNTx) in diagnosis of patients with bone metastases.Methods: Eighty advanced cancer patients were included in the study and bone metastases were noted in 46 of them.The uPyd,uDpd and uNTx were measured in all the cases,and the severity of bone pain and the extent of bone involvement were recorded.Results: The levels of uPyd,uDpd,and uNTx were statistially different in patients with bone involvement and those without bone involvement,and uNTx provided a higher diagnostic accuracy.The level of uPyd was not related to the severity of bone pain,while the levels of uDpd and uNTx were.The levels of uPyd,uDpd,and uNTx were greatly different in patients with bone metastases(P<0.01).Conclusions: Detection of uPyd,uDpd and uNTx has certain diagnostic value in cancer patients with bone metastases.The level of uPyd,uDpd and uNTx may reveal the sevierity of bone pain and the extent of bone involvement.
Objective: To assess the value of urinary pyridol(uPyd),urinary deoxypyridinoline(uDpd) and urinary N terminal telopeptide opeptide(uNTx) in diagnosis of patients with bone metastases.Methods: Eighty advanced cancer patients were included in the study and bone metastases were noted in 46 of them.The uPyd,uDpd and uNTx were measured in all the cases,and the severity of bone pain and the extent of bone involvement were recorded.Results: The levels of uPyd,uDpd,and uNTx were statistially different in patients with bone involvement and those without bone involvement,and uNTx provided a higher diagnostic accuracy.The level of uPyd was not related to the severity of bone pain,while the levels of uDpd and uNTx were.The levels of uPyd,uDpd,and uNTx were greatly different in patients with bone metastases(P<0.01).Conclusions: Detection of uPyd,uDpd and uNTx has certain diagnostic value in cancer patients with bone metastases.The level of uPyd,uDpd and uNTx may reveal the sevierity of bone pain and the extent of bone involvement.
2007, 32(6): 718-719,722.
Abstract:
Objective: To survey and analyze the curreut status of proton pump inhibitor(PPI) for treatment of peptic ulcer and erosive gastritis in Anhui Province.Methods: The therapeutic data of peptic ulcer erosive gastritis from Anhui Province and the national contrast analyxed.Results: The infection rate of Helicobacter pylori(Hp) in peptic ulcer and erosive gastritis was significant difference between Anhui Province and entire country(P<0.01).The total effective rate which Anhui Province used Hp eradication and maintenane therapy was significantly higher than the whole country.The difference was significant(P<0.05);while in peptic ulcer with positive Hp,erosive gastritis with positive or negative Hp.The therapeutic regimens against Hp was no significant difference(P>0.05).Conclusions: Using Hp eradication and maintenane therapy-predominant treatment in peptic ulcer,which is on of the most effection methods in Anhui Province.
Objective: To survey and analyze the curreut status of proton pump inhibitor(PPI) for treatment of peptic ulcer and erosive gastritis in Anhui Province.Methods: The therapeutic data of peptic ulcer erosive gastritis from Anhui Province and the national contrast analyxed.Results: The infection rate of Helicobacter pylori(Hp) in peptic ulcer and erosive gastritis was significant difference between Anhui Province and entire country(P<0.01).The total effective rate which Anhui Province used Hp eradication and maintenane therapy was significantly higher than the whole country.The difference was significant(P<0.05);while in peptic ulcer with positive Hp,erosive gastritis with positive or negative Hp.The therapeutic regimens against Hp was no significant difference(P>0.05).Conclusions: Using Hp eradication and maintenane therapy-predominant treatment in peptic ulcer,which is on of the most effection methods in Anhui Province.
2007, 32(6): 720-722.
Abstract:
Objective: To explore the effects of the target controlled infusion(TCI) for propofol combined with low density isoflurane in children undergoing minor operation.Methods: Forty-eight ASA grade Ⅰ-Ⅱchildren aged 2-6 yr weighting 11.5-25 kg,scheduled for hernia surgery were randomly divided into three groups with 16 cases in each:Ketamine group(group A),propofol TCI group(group B),and propofol TCI combined with low density isoflurane group(group C).The children in group A were given only Ketamine during operation.Heart rate(HR),respiration rate(RR) and pulse oxygen saturation(SpO2) were recorded before induction(T0),skin incision(T1),dragging peritoneum(T2) and sewing skin(T3).All children's reaction at the time of skin incision and dragging peritoneum was recorded.Results: Compared with T0,HR and RR at T1,T2 in group A significantly rised(P<0.05-P<0.01),but the variation of SpO2 was not significant(P>0.05).In group B,compared with T0,RR significantly rised at T1(P<0.01),but HR,RR and SpO2 declined at T2 compared that of in group A(P<0.05).In group C,HR and RR decreased significantly at T1,T2 and T3 compared with those in group Aand group B(P<0.05-P<0.01) and SpO2 declined at the same time compared with group A(P<0.05).The children' SpO2 in the three groups all exceeded 98% with oxygen inhaling.The time of regaining consciousness in group C reduced significantly compared with that in group A and group B(P<0.05).Conclusions: Propofol TCI combined with low density isoflurane in preschool chileren who accepted general anesthesia is safe and satisfied with the life sign stableness and a short revival time.
Objective: To explore the effects of the target controlled infusion(TCI) for propofol combined with low density isoflurane in children undergoing minor operation.Methods: Forty-eight ASA grade Ⅰ-Ⅱchildren aged 2-6 yr weighting 11.5-25 kg,scheduled for hernia surgery were randomly divided into three groups with 16 cases in each:Ketamine group(group A),propofol TCI group(group B),and propofol TCI combined with low density isoflurane group(group C).The children in group A were given only Ketamine during operation.Heart rate(HR),respiration rate(RR) and pulse oxygen saturation(SpO2) were recorded before induction(T0),skin incision(T1),dragging peritoneum(T2) and sewing skin(T3).All children's reaction at the time of skin incision and dragging peritoneum was recorded.Results: Compared with T0,HR and RR at T1,T2 in group A significantly rised(P<0.05-P<0.01),but the variation of SpO2 was not significant(P>0.05).In group B,compared with T0,RR significantly rised at T1(P<0.01),but HR,RR and SpO2 declined at T2 compared that of in group A(P<0.05).In group C,HR and RR decreased significantly at T1,T2 and T3 compared with those in group Aand group B(P<0.05-P<0.01) and SpO2 declined at the same time compared with group A(P<0.05).The children' SpO2 in the three groups all exceeded 98% with oxygen inhaling.The time of regaining consciousness in group C reduced significantly compared with that in group A and group B(P<0.05).Conclusions: Propofol TCI combined with low density isoflurane in preschool chileren who accepted general anesthesia is safe and satisfied with the life sign stableness and a short revival time.
2007, 32(6): 734-736.
Abstract:
Objective: To explore the value of multi-slice spiral computed tomography(MSCT) in the diagnosis of gastric cancer.Methods: Twenty-six cases of plain CT,enhancement CT scanning and multiplanar reconstruction after the stomach becomes low tense and full of water contrast with the results of gastroscope and operation pathology.Results: The rate of MSCT examination about the advancing gastric carcinoma was 100.00% and it achieved 96.15%(25/26) to make a definite diagnosis enhancement CT scan was better than any other ways in diagnosing the TNM-classification of gastric carcinoma.Conclusions: The value of MSCT in examing gastroma is very high and enhancement MSCT scan is the best way in the definite of TNM-classification in gastric carcinoma before operation.
Objective: To explore the value of multi-slice spiral computed tomography(MSCT) in the diagnosis of gastric cancer.Methods: Twenty-six cases of plain CT,enhancement CT scanning and multiplanar reconstruction after the stomach becomes low tense and full of water contrast with the results of gastroscope and operation pathology.Results: The rate of MSCT examination about the advancing gastric carcinoma was 100.00% and it achieved 96.15%(25/26) to make a definite diagnosis enhancement CT scan was better than any other ways in diagnosing the TNM-classification of gastric carcinoma.Conclusions: The value of MSCT in examing gastroma is very high and enhancement MSCT scan is the best way in the definite of TNM-classification in gastric carcinoma before operation.
2007, 32(6): 737-738,741.
Abstract:
Objective: To investigate the clinical value of digital subtraction angiography(DSA) diagnosis and interventional therapy for lower digestive tract hemorrhage of unknown cause.Methods: DSA was performed in 38 patients with lower digestive tract hemorrhage of unknown cause.The locations and causes of hemorrhage were determined by angiography according to the demonstration of contrast medium extravasation,abnormal vasculature and tumor staining.Infusion of vasopressin or embolization with spongia gelatinosa absorbentia and polyvinyl alcohol(PVA) were used after superselective catheter had been inserted in the bleeding artery.Results: Twenty-seven patients were positive in angiogram,17 patients of lower digestive tract hemorrhage caused by arterial venous malformation,6 by tumor,3 by intestinal diverticulm and 1 by caecum ulcer.Twenty-seven patients had been given the interventional therapy.In 17 of 27 patients that had been treated with infusion of vasopressin,13 patients stopped bleeding immediately(76%).In 10 patients with embolization,8 patients stopped bleeding immediately and 2 patients stopped bleeding after 24 hours.Conclusions: DSA and interventional therapy have important value in diagnosis and treatment of patients with lower digestive tract hemorrhage of unknown cause.
Objective: To investigate the clinical value of digital subtraction angiography(DSA) diagnosis and interventional therapy for lower digestive tract hemorrhage of unknown cause.Methods: DSA was performed in 38 patients with lower digestive tract hemorrhage of unknown cause.The locations and causes of hemorrhage were determined by angiography according to the demonstration of contrast medium extravasation,abnormal vasculature and tumor staining.Infusion of vasopressin or embolization with spongia gelatinosa absorbentia and polyvinyl alcohol(PVA) were used after superselective catheter had been inserted in the bleeding artery.Results: Twenty-seven patients were positive in angiogram,17 patients of lower digestive tract hemorrhage caused by arterial venous malformation,6 by tumor,3 by intestinal diverticulm and 1 by caecum ulcer.Twenty-seven patients had been given the interventional therapy.In 17 of 27 patients that had been treated with infusion of vasopressin,13 patients stopped bleeding immediately(76%).In 10 patients with embolization,8 patients stopped bleeding immediately and 2 patients stopped bleeding after 24 hours.Conclusions: DSA and interventional therapy have important value in diagnosis and treatment of patients with lower digestive tract hemorrhage of unknown cause.
2007, 32(6): 739-741.
Abstract:
Objective: To improve CT imaging qualities and reduce rate of missed diagnosis in basicranial fracture by optimizing patterns of CT scanning and technical parameter.Methods: The water model was used and the imaging noise was acquired and compared with different X-ray amount(50 mAs,100 mAs,180 mAs and 225 mAs),spiral and non-spiral CT scanning patterns.Conventional and optimized technical parameter plain CT scanning were performed in 41 patients with craniocerebral trauma.The acquired images were analyzed.Results: Minimal noise was acquired with high X-ray amount(225 mAs) and non-spiral CT scanning.Compared images of optimized technical parameters with conventional CT scanning,it could be found that the thinner of the slice thickness(thinner than 3 mm),the less of the skeletal artificial effects.Imaging resolving power of fine basal skeletal structure could be improved with high resolution reconstruction(H80s) and optimal window width(W2000) and window level(L600).Conclusions: The acquired images are clear with optimized technical parameters CT scanning in patients with basicranial fracture.It might increase the finding rate of basicranial fracture.
Objective: To improve CT imaging qualities and reduce rate of missed diagnosis in basicranial fracture by optimizing patterns of CT scanning and technical parameter.Methods: The water model was used and the imaging noise was acquired and compared with different X-ray amount(50 mAs,100 mAs,180 mAs and 225 mAs),spiral and non-spiral CT scanning patterns.Conventional and optimized technical parameter plain CT scanning were performed in 41 patients with craniocerebral trauma.The acquired images were analyzed.Results: Minimal noise was acquired with high X-ray amount(225 mAs) and non-spiral CT scanning.Compared images of optimized technical parameters with conventional CT scanning,it could be found that the thinner of the slice thickness(thinner than 3 mm),the less of the skeletal artificial effects.Imaging resolving power of fine basal skeletal structure could be improved with high resolution reconstruction(H80s) and optimal window width(W2000) and window level(L600).Conclusions: The acquired images are clear with optimized technical parameters CT scanning in patients with basicranial fracture.It might increase the finding rate of basicranial fracture.
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