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2009 Vol. 34, No. 11
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2009, 34(11): 953-955.
Abstract:
Objective: To observe the influence of glucose on the expression of Apolipoprotein E(Apo E) in human monocytic leukemia cell line(THP-1) macrophages.Methods: THP-1 cells were induced to macrophages with phorbol,and then treated with RPMI 1640 culture medium containing diferent concentrations of glucose for 72 hours.Apo E mRNA and protein level were analyzed by RT-PCR and Western Blot respectively,meanwhile the viability of macrophages was assayed with MTT method.Results: Glucose significantly decreased Apo E expression of THP-1 macrophages in a dose-dependent manner(20-30 mmol/L).Conclusions: Glucose decreases Apo E expression of THP-1 macrophages,which might be one of the mechanisms of proatherosclerosis of glucose.
Objective: To observe the influence of glucose on the expression of Apolipoprotein E(Apo E) in human monocytic leukemia cell line(THP-1) macrophages.Methods: THP-1 cells were induced to macrophages with phorbol,and then treated with RPMI 1640 culture medium containing diferent concentrations of glucose for 72 hours.Apo E mRNA and protein level were analyzed by RT-PCR and Western Blot respectively,meanwhile the viability of macrophages was assayed with MTT method.Results: Glucose significantly decreased Apo E expression of THP-1 macrophages in a dose-dependent manner(20-30 mmol/L).Conclusions: Glucose decreases Apo E expression of THP-1 macrophages,which might be one of the mechanisms of proatherosclerosis of glucose.
2009, 34(11): 956-958.
Abstract:
Objective: To explore the effect of different doses of magnesium sulfate(MgSO4) on reperfusion injury of mice with general cerebral ischemia.Methods: The mice were randomly divided into control group,ischemia reperfusion(I/R) group,MgSO4 90 mg/kg group,MgSO4 180 mg/kg group and MgSO4 360 mg/kg group.General cerebral ischemia model was established by blocking the bilateral common carotid arteries and pressing the soft tissues in carotid.The mice were reperfused for 60 min after 30 min ischemia.The change of EEG was monitored and the pathological change in morphology was observed.The content of nitric oxidel(NO) and the activity of nitric oxide synthase(NOS) and inducible NOS(iNOS) were also detected.Results: Compared with MgSO4 groups,the content of NO(P<0.01),the activities of NOS and iNOS in the I/R group were decreased(P<0.01),and the pathologic damage in brain tissues relieved.Conclusions: The curative effect of MgSO4 on cerebral ischemia-reperfusion injury might be associated to the decrease of the NO contents and the lowering of the activities of NOS and iNOS.
Objective: To explore the effect of different doses of magnesium sulfate(MgSO4) on reperfusion injury of mice with general cerebral ischemia.Methods: The mice were randomly divided into control group,ischemia reperfusion(I/R) group,MgSO4 90 mg/kg group,MgSO4 180 mg/kg group and MgSO4 360 mg/kg group.General cerebral ischemia model was established by blocking the bilateral common carotid arteries and pressing the soft tissues in carotid.The mice were reperfused for 60 min after 30 min ischemia.The change of EEG was monitored and the pathological change in morphology was observed.The content of nitric oxidel(NO) and the activity of nitric oxide synthase(NOS) and inducible NOS(iNOS) were also detected.Results: Compared with MgSO4 groups,the content of NO(P<0.01),the activities of NOS and iNOS in the I/R group were decreased(P<0.01),and the pathologic damage in brain tissues relieved.Conclusions: The curative effect of MgSO4 on cerebral ischemia-reperfusion injury might be associated to the decrease of the NO contents and the lowering of the activities of NOS and iNOS.
2009, 34(11): 959-961.
Abstract:
Objective: To compare the expression of HER-2/neu/c-erbB-2 oncogene detected by chromogenic in situ hybridization(CISH) and immunohistochemistry(IHC) in breast cancer. Methods: The formalin-fixed paraffin-embedded breast cancer samples(44 cases) were selected and these samples were detected by IHC.Among them,there were 9 cases with negative expression,9 cases with score(+),13 cases with score(++),13 cases with score(+++).Twenty-two cases with HER-2 IHC positively expressed were examined retrospectively(including 9 cases with score(+) and 13 cases with score(+++).Results: In the nine cases with score(+) by IHC,all cases were negatively expressed with CISH.Two of the 13 cases with score(+++) showed CISH-negative(15.38%),1 cases failed to show amplification,the remaining 10 cases showed gene amplification,thus the concordant ratio between IHC and CISH was 76.92%.Certain concordance to the examination of HER-2 status(P=0.001) was found in the two kinds of methods.The results of gene amplification detected by IHC and CISH had no concordance with types of breast cancer(P<0.05).Conclusions: The results of gene amplification detected by CISH have high concordance with IHC.IHC is a choice in primary screening for HER-2 expression status.The concordant ratio between IHC and CISH is high,CISH is more accurate than IHC.Patients with proven amplification of HER-2/neu may benefit from treatment with anti-HER-2 monoclonal antibodies.
Objective: To compare the expression of HER-2/neu/c-erbB-2 oncogene detected by chromogenic in situ hybridization(CISH) and immunohistochemistry(IHC) in breast cancer. Methods: The formalin-fixed paraffin-embedded breast cancer samples(44 cases) were selected and these samples were detected by IHC.Among them,there were 9 cases with negative expression,9 cases with score(+),13 cases with score(++),13 cases with score(+++).Twenty-two cases with HER-2 IHC positively expressed were examined retrospectively(including 9 cases with score(+) and 13 cases with score(+++).Results: In the nine cases with score(+) by IHC,all cases were negatively expressed with CISH.Two of the 13 cases with score(+++) showed CISH-negative(15.38%),1 cases failed to show amplification,the remaining 10 cases showed gene amplification,thus the concordant ratio between IHC and CISH was 76.92%.Certain concordance to the examination of HER-2 status(P=0.001) was found in the two kinds of methods.The results of gene amplification detected by IHC and CISH had no concordance with types of breast cancer(P<0.05).Conclusions: The results of gene amplification detected by CISH have high concordance with IHC.IHC is a choice in primary screening for HER-2 expression status.The concordant ratio between IHC and CISH is high,CISH is more accurate than IHC.Patients with proven amplification of HER-2/neu may benefit from treatment with anti-HER-2 monoclonal antibodies.
2009, 34(11): 962-965.
Abstract:
Objective: To study the protective effect of tiopronin and splenectomy on the hepatic ischemia reperfusion injury in rats,and to investigate its mechanism.Methods: Ninety male Wistar rats were divided into sham operation group,ischemia-reperfusion(IR) group,tiopronin group,splenectomy group and tiopronin+splenectomy group.The hepatic artery and portal vein to the left and median liver lobes were occluded;the levels of serum alanine amintransperase(ALT),superoxide dismutase(SOD),malondialdehyde(MDA) and the pathological variation were observed;the necrosis of the hepatocyte and the infiltration of neutrophilic granulocytes were determined by HE staining.Results: The levels of ALT and MDA in serum in IR group was significant higher than that in the sham group(P<0.01);the levels of ALT and MDA in tiopronin group and splenectomy group were significantly lower than that in IR group(P<0.01),and the level of ALT and MDA in tiopronin + splenectomy group were significantly lower than that in IR group,tiopronin group and splenectomy group(P<0.01).The level of SOD in serum in tiopronin + splenectomy group was significantly higher than that in IR,tiopronin and splenectomy group(P<0.01),and the difference was significant between IR group and tiopronin groups(P<0.01);histological lesion of the liver was observed in IR group,and there was an obvious increase of neutrophilic granulocytes(P<0.01);the necrosis of the liver and the number of neutrophilic granulocytes in tiopronin group and splenectomy groups were significantly lower than those in IR group(P<0.05 to P<0.01).Conclusions: Tiopronin can increase the activity of SOD,decrease the level of MDA and protect the liver from ischemia reperfusion injury in rats,and splenectomy has the same function as tiopronin.The combined therapy of tiopronin and splenectomy may enhance the protective effect on the hepatic ischemia reperfusion injury in rats.
Objective: To study the protective effect of tiopronin and splenectomy on the hepatic ischemia reperfusion injury in rats,and to investigate its mechanism.Methods: Ninety male Wistar rats were divided into sham operation group,ischemia-reperfusion(IR) group,tiopronin group,splenectomy group and tiopronin+splenectomy group.The hepatic artery and portal vein to the left and median liver lobes were occluded;the levels of serum alanine amintransperase(ALT),superoxide dismutase(SOD),malondialdehyde(MDA) and the pathological variation were observed;the necrosis of the hepatocyte and the infiltration of neutrophilic granulocytes were determined by HE staining.Results: The levels of ALT and MDA in serum in IR group was significant higher than that in the sham group(P<0.01);the levels of ALT and MDA in tiopronin group and splenectomy group were significantly lower than that in IR group(P<0.01),and the level of ALT and MDA in tiopronin + splenectomy group were significantly lower than that in IR group,tiopronin group and splenectomy group(P<0.01).The level of SOD in serum in tiopronin + splenectomy group was significantly higher than that in IR,tiopronin and splenectomy group(P<0.01),and the difference was significant between IR group and tiopronin groups(P<0.01);histological lesion of the liver was observed in IR group,and there was an obvious increase of neutrophilic granulocytes(P<0.01);the necrosis of the liver and the number of neutrophilic granulocytes in tiopronin group and splenectomy groups were significantly lower than those in IR group(P<0.05 to P<0.01).Conclusions: Tiopronin can increase the activity of SOD,decrease the level of MDA and protect the liver from ischemia reperfusion injury in rats,and splenectomy has the same function as tiopronin.The combined therapy of tiopronin and splenectomy may enhance the protective effect on the hepatic ischemia reperfusion injury in rats.
2009, 34(11): 965-968.
Abstract:
Objective: To study the correlations of the expressions of nm23 and bcl-2 genes with the invasion and metastasis in papillary thyroid carcinoma(PTC).Methods: The expressions of nm23 and bcl-2 were detected by immunohistochemical SP method in the thyroid tissues from 157 papillary thyroid carcinoma and 30 thyroid adenoma.Results: The positive rate of nm23 expression in PTC group was higher than in thyroid adenoma group(P<0.05);the positive rate of nm23 expression with neck lymph node metastasis was lower than in the group without neck lymph node metastasis(P<0.01);with the increase of PTC tumor pathological grade,the positive rate of nm23 expression was decreased(P<0.01).The positive rate of bcl-2 expression in PTC group was higher than in thyroid adenoma group(P<0.01);the positive rate of bcl-2 expression with neck lymph node metastasis was higher than in the group without neck lymph node metastasis(P<0.05);with the increase of PTC tumor pathological grade,the positive rate of bcl-2 expression was increased(P<0.01).Conclusions: The expressions of nm23 and bcl-2 gene are closely correlated with the invasion and metastasis in PTC and the papillary thyroid carcinoma's metastasis is positively correlated with bcl-2 expression and negatively correlated with nm23 expression.
Objective: To study the correlations of the expressions of nm23 and bcl-2 genes with the invasion and metastasis in papillary thyroid carcinoma(PTC).Methods: The expressions of nm23 and bcl-2 were detected by immunohistochemical SP method in the thyroid tissues from 157 papillary thyroid carcinoma and 30 thyroid adenoma.Results: The positive rate of nm23 expression in PTC group was higher than in thyroid adenoma group(P<0.05);the positive rate of nm23 expression with neck lymph node metastasis was lower than in the group without neck lymph node metastasis(P<0.01);with the increase of PTC tumor pathological grade,the positive rate of nm23 expression was decreased(P<0.01).The positive rate of bcl-2 expression in PTC group was higher than in thyroid adenoma group(P<0.01);the positive rate of bcl-2 expression with neck lymph node metastasis was higher than in the group without neck lymph node metastasis(P<0.05);with the increase of PTC tumor pathological grade,the positive rate of bcl-2 expression was increased(P<0.01).Conclusions: The expressions of nm23 and bcl-2 gene are closely correlated with the invasion and metastasis in PTC and the papillary thyroid carcinoma's metastasis is positively correlated with bcl-2 expression and negatively correlated with nm23 expression.
2009, 34(11): 969-971.
Abstract:
Objective: To investigate the changes of the function of pancreatic island and insulin resistance(IR) in cases with impaired fasting glucose(IFG) received different interventions.Methods: A total of 127 patients with IFG were divided randomly into three groups to be administrated with different interventions:life style intervention group(received dietary therapy and exercise training,n=41),plus metformin group(received dietary therapy and exercise training and metformin,n=45) and plus rosiglitazone group(received dietary therapy and exercise training and rosiglitazone,n=41).The body mass index,fasting plasma glucose,2 h plasma glucose,fasting insulin and 2 h insulin were measured both before and after the interventions.Finally,glucose tolerance tests recheck were and the changes of insulin resistance and pancreatic island function of each group were compared.Results: The rates of transformation of IFG to diabetes mellitus every year in plus metformin group(6.7%) and plus rosiglitazone group(7.3%) were significantly lower than that of life style intervention group(P<0.05).There were significantly improvements of insulin resistance in both of the two plus groups.Conclusions: The morbidity of IFG is closely related to the IR.Metformin or rosiglitazone can efficiently improve the IR and reduce the transformation of IFG to diabetes mellitus.
Objective: To investigate the changes of the function of pancreatic island and insulin resistance(IR) in cases with impaired fasting glucose(IFG) received different interventions.Methods: A total of 127 patients with IFG were divided randomly into three groups to be administrated with different interventions:life style intervention group(received dietary therapy and exercise training,n=41),plus metformin group(received dietary therapy and exercise training and metformin,n=45) and plus rosiglitazone group(received dietary therapy and exercise training and rosiglitazone,n=41).The body mass index,fasting plasma glucose,2 h plasma glucose,fasting insulin and 2 h insulin were measured both before and after the interventions.Finally,glucose tolerance tests recheck were and the changes of insulin resistance and pancreatic island function of each group were compared.Results: The rates of transformation of IFG to diabetes mellitus every year in plus metformin group(6.7%) and plus rosiglitazone group(7.3%) were significantly lower than that of life style intervention group(P<0.05).There were significantly improvements of insulin resistance in both of the two plus groups.Conclusions: The morbidity of IFG is closely related to the IR.Metformin or rosiglitazone can efficiently improve the IR and reduce the transformation of IFG to diabetes mellitus.
2009, 34(11): 972-974.
Abstract:
Objective: To summarize the experiences in surgical treatment of acute deep venous thrombosis(DVT) in the lower extremities.Methods: Sixty-six cases of acute DVT underwent femoral venotomy and thrombectomy,and the cases accompanied with left iliac venous stenosis were performed iliac venous balloon dilatation and stent placement at the same time.Results: The operation was successful in all the cases.The clinical symptoms disappeared 3 days after operation.Complete subsidence of swelling was observed in 56 cases and partial subsidence in 10 cases when discharged.Conclusions: Surgery combined with comprehensive therapies is effective on acute DVT in the lower extremities.
Objective: To summarize the experiences in surgical treatment of acute deep venous thrombosis(DVT) in the lower extremities.Methods: Sixty-six cases of acute DVT underwent femoral venotomy and thrombectomy,and the cases accompanied with left iliac venous stenosis were performed iliac venous balloon dilatation and stent placement at the same time.Results: The operation was successful in all the cases.The clinical symptoms disappeared 3 days after operation.Complete subsidence of swelling was observed in 56 cases and partial subsidence in 10 cases when discharged.Conclusions: Surgery combined with comprehensive therapies is effective on acute DVT in the lower extremities.
2009, 34(11): 975-977.
Abstract:
Objective: To explore the clinical characteristics of angiography in patients of different ages with coronary heart disease(CHD).Methods: One hundred forty-eight CHD patients were divided into middle age-group(<60 years old),elderly group(60-74 years old) and older age-group(>74 years old).Their clinical data,biochemical indicators and coronary arteriongraphy results were compared and analyzed statistically.Results: There was less hypertension in the middle age-group than in the older age-group(P<0.05).More single-vessel lesion was found in the middle-aged,and multiple vessel diseases occurred more frequently in the elderly and the older aged(P<0.05).Right coronary artery lesions was more frequently observed in the aged than the middle-aged(P<0.05).ACC/AHA scores did not show significant statistical difference in the three groups(P>0.05).There were more diffuse lesions in the elderly group and older age-group than in the middle age-group(P<0.05).Conclusions: Coronary angiography demonstrates different characteristics for patients of different ages,and effective measures should be taken accordingly,which will be of great significance for the treatment of patients with coronary artery disease.
Objective: To explore the clinical characteristics of angiography in patients of different ages with coronary heart disease(CHD).Methods: One hundred forty-eight CHD patients were divided into middle age-group(<60 years old),elderly group(60-74 years old) and older age-group(>74 years old).Their clinical data,biochemical indicators and coronary arteriongraphy results were compared and analyzed statistically.Results: There was less hypertension in the middle age-group than in the older age-group(P<0.05).More single-vessel lesion was found in the middle-aged,and multiple vessel diseases occurred more frequently in the elderly and the older aged(P<0.05).Right coronary artery lesions was more frequently observed in the aged than the middle-aged(P<0.05).ACC/AHA scores did not show significant statistical difference in the three groups(P>0.05).There were more diffuse lesions in the elderly group and older age-group than in the middle age-group(P<0.05).Conclusions: Coronary angiography demonstrates different characteristics for patients of different ages,and effective measures should be taken accordingly,which will be of great significance for the treatment of patients with coronary artery disease.
2009, 34(11): 978-980.
Abstract:
Objective: To study the expression of vascular endothelial growth factor-C(VEGF-C) in stomach cancer and its correlation with lymphatic metastasis and prognosis.Methods: The specimens from 80 patients with primary gastric cancer and 20 specimens from superficial gastritis as controls were examined using S-P immunohistochemistry.The expression of VEGF-C in the stomach cancer and its relationship with lymphatic metastasis and prognosis were studied.Results: Immunohistological staining with VEGF-C specific polyclonal antibody showed cytoplasmic and membranous staining in the cancer cells.The expression of VEGF-C in gastric carcinoma was significantly higher than that in control and was correlated with lymphatic metastasis(P<0.01);Kaplan-Meier survival analysis showed that VEGF-C was an independent factor for the prognosis of the patients.Conclusions: VEGF-C is expressed in stomach cancer and its overexpression correlates with the lymphatic metastasis and the prognosis.
Objective: To study the expression of vascular endothelial growth factor-C(VEGF-C) in stomach cancer and its correlation with lymphatic metastasis and prognosis.Methods: The specimens from 80 patients with primary gastric cancer and 20 specimens from superficial gastritis as controls were examined using S-P immunohistochemistry.The expression of VEGF-C in the stomach cancer and its relationship with lymphatic metastasis and prognosis were studied.Results: Immunohistological staining with VEGF-C specific polyclonal antibody showed cytoplasmic and membranous staining in the cancer cells.The expression of VEGF-C in gastric carcinoma was significantly higher than that in control and was correlated with lymphatic metastasis(P<0.01);Kaplan-Meier survival analysis showed that VEGF-C was an independent factor for the prognosis of the patients.Conclusions: VEGF-C is expressed in stomach cancer and its overexpression correlates with the lymphatic metastasis and the prognosis.
2009, 34(11): 981-983.
Abstract:
Objective: To explore the early diagnosis and pertinent treatment of cesarean scar pregnancy(CSP).Methods: The clinical data of eleven patients with CSP were analyzed retrospectively.Results: Among the eleven cases,only 2 cases had clear diagnosis before artificial abortion.Three cases had uterine rupture and massive hemorrhage during artificial abortion.Six cases had vaginal massive hemorrhage after artificial abortion.All of them were diagnosed by colored B-ultrasound.Among the eleven cases,eight cases were treated by uterine artery embolization(UAE) combination with methotrexate(MTX) and had curettage 7-10 days after UAE.No case had the occurence of massive hemorrhage.All of them were successful.Two cases were treated with MTX and curratage with the help of ultrasound.There was about 400 ml bleeding during operation in every case.Only one case was treated by oral mifepristone and there was treated again by UAE because of massive hemorrhage during curettage.Conclusions: Color B-ultrasound,especially color Doppler transvaginal ultrasonography is the main method in diagnosis of CSP.UAE combination with MTX is one of the best effective treatment.
Objective: To explore the early diagnosis and pertinent treatment of cesarean scar pregnancy(CSP).Methods: The clinical data of eleven patients with CSP were analyzed retrospectively.Results: Among the eleven cases,only 2 cases had clear diagnosis before artificial abortion.Three cases had uterine rupture and massive hemorrhage during artificial abortion.Six cases had vaginal massive hemorrhage after artificial abortion.All of them were diagnosed by colored B-ultrasound.Among the eleven cases,eight cases were treated by uterine artery embolization(UAE) combination with methotrexate(MTX) and had curettage 7-10 days after UAE.No case had the occurence of massive hemorrhage.All of them were successful.Two cases were treated with MTX and curratage with the help of ultrasound.There was about 400 ml bleeding during operation in every case.Only one case was treated by oral mifepristone and there was treated again by UAE because of massive hemorrhage during curettage.Conclusions: Color B-ultrasound,especially color Doppler transvaginal ultrasonography is the main method in diagnosis of CSP.UAE combination with MTX is one of the best effective treatment.
2009, 34(11): 983-985.
Abstract:
Objective: To investigate the efficacy and capability of loop electrosurgical excisional procedure(LEEP) in treatment of cervical introepithelial neoplasia(CIN).Methods: Fifty-four patients with CIN were treated by LEEP under local anesthesia and colposcopic guidance.The operation time,hemorrhage volume,the change of histopathology and complications were analyzed retrospectively.Results: For the LEEP,the mean operation time was 4.5 min,mean hemorrhage volume was 8.6 ml.After LEEP,66.67% was consistent with the changes of histopathology,20.37% with upgrade,and 12.96% with downgrade.The cure rate was achieved up to 94.4%.Conclusions: LEEP is a kind of safe,effective and economical method for the management of CIN.So it is worthwhile to popularize LEEP in gynecological field.
Objective: To investigate the efficacy and capability of loop electrosurgical excisional procedure(LEEP) in treatment of cervical introepithelial neoplasia(CIN).Methods: Fifty-four patients with CIN were treated by LEEP under local anesthesia and colposcopic guidance.The operation time,hemorrhage volume,the change of histopathology and complications were analyzed retrospectively.Results: For the LEEP,the mean operation time was 4.5 min,mean hemorrhage volume was 8.6 ml.After LEEP,66.67% was consistent with the changes of histopathology,20.37% with upgrade,and 12.96% with downgrade.The cure rate was achieved up to 94.4%.Conclusions: LEEP is a kind of safe,effective and economical method for the management of CIN.So it is worthwhile to popularize LEEP in gynecological field.
2009, 34(11): 986-988.
Abstract:
Objective: To study the procedure and clinical effect of modified non-elongated cheiloplasty and modified Millard's operation for repair of bilateral cleft lips.Methods: Fifty-four cases of bilateral cleft lips were treated by modified non-elongated cheiloplasty or by modified Millard's operation.The outcome was evaluated by the new standards.Results: The results were good in 44.74% of the cases by modified non-elongated cheiloplasty and in 43.75% of the cases by modified Millard's operation.Conclusions: Modified Millard's operation is more suitable for repair of incomplete bilateral cleft lips,while modified non-elongated cheiloplasty for other types of bilateral cleft lips.
Objective: To study the procedure and clinical effect of modified non-elongated cheiloplasty and modified Millard's operation for repair of bilateral cleft lips.Methods: Fifty-four cases of bilateral cleft lips were treated by modified non-elongated cheiloplasty or by modified Millard's operation.The outcome was evaluated by the new standards.Results: The results were good in 44.74% of the cases by modified non-elongated cheiloplasty and in 43.75% of the cases by modified Millard's operation.Conclusions: Modified Millard's operation is more suitable for repair of incomplete bilateral cleft lips,while modified non-elongated cheiloplasty for other types of bilateral cleft lips.
2009, 34(11): 988-990.
Abstract:
Objective: To explore the optimal surgical treatment time and procedure for traumatic cataract extraction and intraocular lens implantation.Methods: Twenty-eight cases of ocular perforation injury combined with traumatic cataract were performed debridement and suturing.The surgery time was decided according to the damage degree of the lens.After erasing the lens cortex completely,the intraocular lens was implanted.Results: No serious complication occurred in all the 28 cases,and the vision of most cases restored to 0.15-0.8.Conclusions: Proper surgery time and procedure may lead to better treatment results.
Objective: To explore the optimal surgical treatment time and procedure for traumatic cataract extraction and intraocular lens implantation.Methods: Twenty-eight cases of ocular perforation injury combined with traumatic cataract were performed debridement and suturing.The surgery time was decided according to the damage degree of the lens.After erasing the lens cortex completely,the intraocular lens was implanted.Results: No serious complication occurred in all the 28 cases,and the vision of most cases restored to 0.15-0.8.Conclusions: Proper surgery time and procedure may lead to better treatment results.
2009, 34(11): 991-992.
Abstract:
Objective: To evaluate the computed tomography(CT) and C-arm X-ray guided percutaneous vertebroplasty(PVP) in treatment of thoracolumbar fractures.Methods: Sixty-six cases of thoracolumbar fractures underwent percutaneous vertebroplasty with the guidance of CT and C-arm X-ray machine.The visual analog scale(VAS) was used to assess the effects before and after PVP.Results: The PVP was performed successfully in all the 66 cases(a total of 82 vertebrae).The mean operation time was 30 min per vertebra.The VAS score at 2 weeks after operation(2.8±0.15).Fifty-six patients were followed up for 3-35 months.No recurrence or exacerbation of chest and back pain was noted.The height of the veterbral body had no change,and there was no fracture in the adjacent veterbral bodies.Conclusions: Percutaneous vertebroplasty under the guidance of computer tomography and C-arm X-ray machine is safe and effective for treatment of thoracolumbar fractures.
Objective: To evaluate the computed tomography(CT) and C-arm X-ray guided percutaneous vertebroplasty(PVP) in treatment of thoracolumbar fractures.Methods: Sixty-six cases of thoracolumbar fractures underwent percutaneous vertebroplasty with the guidance of CT and C-arm X-ray machine.The visual analog scale(VAS) was used to assess the effects before and after PVP.Results: The PVP was performed successfully in all the 66 cases(a total of 82 vertebrae).The mean operation time was 30 min per vertebra.The VAS score at 2 weeks after operation(2.8±0.15).Fifty-six patients were followed up for 3-35 months.No recurrence or exacerbation of chest and back pain was noted.The height of the veterbral body had no change,and there was no fracture in the adjacent veterbral bodies.Conclusions: Percutaneous vertebroplasty under the guidance of computer tomography and C-arm X-ray machine is safe and effective for treatment of thoracolumbar fractures.
2009, 34(11): 993-994.
Abstract:
Objective: To evaluate the clinical efficacy of retroperitoneal laparoscopy in resection of the adrenal tumor.Methods: Twenty eight patients with adrenal tumors underwent retroperitoneal laparoscopic surgery.Results: Retroperitoneal laparoscopic surgery was successfully applied to all the 28 cases.The operation time was 60-160 min;the intra-operative blood loss was 50-100 ml;and the postoperative hospitalization was 4-7 days.No serious complication occurred during the operation and follow-up period.Conclusions: Retroperitoneal laparoscopic adrenalectomy is safe and reliable.It has a promising future in urologic practice.
Objective: To evaluate the clinical efficacy of retroperitoneal laparoscopy in resection of the adrenal tumor.Methods: Twenty eight patients with adrenal tumors underwent retroperitoneal laparoscopic surgery.Results: Retroperitoneal laparoscopic surgery was successfully applied to all the 28 cases.The operation time was 60-160 min;the intra-operative blood loss was 50-100 ml;and the postoperative hospitalization was 4-7 days.No serious complication occurred during the operation and follow-up period.Conclusions: Retroperitoneal laparoscopic adrenalectomy is safe and reliable.It has a promising future in urologic practice.
2009, 34(11): 995-997.
Abstract:
Objective: To investigate the correlation of carotid atherosclerosis(CAS),high-sensitive C-reactive protein(hs-CRP) and fibrinogen(FIB) in patients with coronary heart disease(CHD).Methods: Seventy-eight patients who had received coronery artery angiography(CAG) examination were included in this study.According to the results of CAG,the patients were divided into single vessel group and multiple vessel groups.The intima media thickness(IMT) and plague of each patient was measured by ultrasound.The levels of hs-CRP and FIB were measured and compared.Results: The levels of IMT,plagues,hs-CRP and FIB in CHD group were higher than those in negative group(P<0.05 to P<0.01).CAS,hs-CRP and FIB were positively correlated with the count of coronary atheroscleroic lesions(P<0.05 to P<0.01).Conclusions: Carotid ultrasounic examination could help to predict the presence of coronary artery disease.The levels of hs-CRP and FIB play an important role in the initiation and progression of CHD.The IMT,hs-CRP and FIB have positive correlation with the count of coronary atheroscleroic lesions.
Objective: To investigate the correlation of carotid atherosclerosis(CAS),high-sensitive C-reactive protein(hs-CRP) and fibrinogen(FIB) in patients with coronary heart disease(CHD).Methods: Seventy-eight patients who had received coronery artery angiography(CAG) examination were included in this study.According to the results of CAG,the patients were divided into single vessel group and multiple vessel groups.The intima media thickness(IMT) and plague of each patient was measured by ultrasound.The levels of hs-CRP and FIB were measured and compared.Results: The levels of IMT,plagues,hs-CRP and FIB in CHD group were higher than those in negative group(P<0.05 to P<0.01).CAS,hs-CRP and FIB were positively correlated with the count of coronary atheroscleroic lesions(P<0.05 to P<0.01).Conclusions: Carotid ultrasounic examination could help to predict the presence of coronary artery disease.The levels of hs-CRP and FIB play an important role in the initiation and progression of CHD.The IMT,hs-CRP and FIB have positive correlation with the count of coronary atheroscleroic lesions.
2009, 34(11): 997-999.
Abstract:
Objective: To compare the efficacy and side effects of docetaxel/cisplatin regiment(DP) and gemcitabine/cisplatin regiment(GP) in treatment of advanced non-small cell lung cancer(NSCLC).Methods: A total of 80 patients with advanced NSCLC were randomized into 2 groups.The patients in docetaxel group were received docetaxel at 37.5 mg/m2 on day 1 and day 8,cisplatin at 75 mg/m2 on day 2 to day 4.In gemcitabine group,the patients were received gemcitabine at 1 000 mg/m2 on day 1 and day 8,and the same method of cisplatin as in docetaxel group.The treatment schedule was recycled every 3 weeks.The toxicity and life quality were evaluated after every cycle.The efficacy and survival rate were evaluated at the end of two cycles.Results: The response rates in docetaxel group and gemcitabine group were 45.00% and 42.50% respectively.The main side effects were myelosuppression,nausea and vomiting.Conclusions: Docetaxel/cisplatin and gemcitabine/cisplatin regiments had the high efficacys in treatment of advanced NSCLC patients.
Objective: To compare the efficacy and side effects of docetaxel/cisplatin regiment(DP) and gemcitabine/cisplatin regiment(GP) in treatment of advanced non-small cell lung cancer(NSCLC).Methods: A total of 80 patients with advanced NSCLC were randomized into 2 groups.The patients in docetaxel group were received docetaxel at 37.5 mg/m2 on day 1 and day 8,cisplatin at 75 mg/m2 on day 2 to day 4.In gemcitabine group,the patients were received gemcitabine at 1 000 mg/m2 on day 1 and day 8,and the same method of cisplatin as in docetaxel group.The treatment schedule was recycled every 3 weeks.The toxicity and life quality were evaluated after every cycle.The efficacy and survival rate were evaluated at the end of two cycles.Results: The response rates in docetaxel group and gemcitabine group were 45.00% and 42.50% respectively.The main side effects were myelosuppression,nausea and vomiting.Conclusions: Docetaxel/cisplatin and gemcitabine/cisplatin regiments had the high efficacys in treatment of advanced NSCLC patients.
2009, 34(11): 1008-1009.
Abstract:
Objective: To evaluate the function of the echocardiogram in percutaneous closure of ventricular septal defects(VSD).Methods: The echocardiography was performed strictly for selection of patients,monitored the sites,shapes of occluder,whether there's any residual shunt,aortic valvular and atrioventricular valvular regurgitations and the process of the occlusion.The echocardiography data after operation was reviewed.Results: In 150 cases,118 cases got successful closure.Right position of occluder and neither residual shunt nor other complications were observed during the follow-up.Conclusions: The echocardiography is a very facilitated,reliable,repetitive follow-up mearsure with high clinical application value in the interventional treatment of ventricular septal defect.
Objective: To evaluate the function of the echocardiogram in percutaneous closure of ventricular septal defects(VSD).Methods: The echocardiography was performed strictly for selection of patients,monitored the sites,shapes of occluder,whether there's any residual shunt,aortic valvular and atrioventricular valvular regurgitations and the process of the occlusion.The echocardiography data after operation was reviewed.Results: In 150 cases,118 cases got successful closure.Right position of occluder and neither residual shunt nor other complications were observed during the follow-up.Conclusions: The echocardiography is a very facilitated,reliable,repetitive follow-up mearsure with high clinical application value in the interventional treatment of ventricular septal defect.
2009, 34(11): 1010-1011.
Abstract:
Objective: To evaluate the clinical value of ultrasound-guided one-step percutaneus transhepatic biliary drainage(PTBD).Methods: Clinical data of patients treated with PTBD were retrospectively analyzed.Results: Sixty-eight times of 62 cases of PTBD were done,67 times were successful among them,only 1 time was failed.The symptom of jaundice was alleviated obviously in 58 cases one week post-operation,no obvious effect in 3 case.Three cases were treated with PTBD again whose catheters were displaced after two days.Conclusions: Ultrasound-guided one-step percutaneus transhepatic biliary drainage is a simple and safe procedure which is recommended to apply in clinical practice.
Objective: To evaluate the clinical value of ultrasound-guided one-step percutaneus transhepatic biliary drainage(PTBD).Methods: Clinical data of patients treated with PTBD were retrospectively analyzed.Results: Sixty-eight times of 62 cases of PTBD were done,67 times were successful among them,only 1 time was failed.The symptom of jaundice was alleviated obviously in 58 cases one week post-operation,no obvious effect in 3 case.Three cases were treated with PTBD again whose catheters were displaced after two days.Conclusions: Ultrasound-guided one-step percutaneus transhepatic biliary drainage is a simple and safe procedure which is recommended to apply in clinical practice.
2009, 34(11): 1012-1014.
Abstract:
Objective: To evaluate X-ray examination in diagnosis of congenital hypertrophic pyloric stenosis(CHPS).Methods: Twenty cases with CHPS confirmed by surgery and histopathology in our hospital during 2008 to 2009 underwent X-ray examination,and the X-ray manifestation was analyzed retrospectively.Results: Stomach dilatation was observed in 20 cases,stomach emptypostpone in 20 cases and gastro-esophageal hernia in 8 cases.The "line" signs in 20 cases,the "double-track" signs in 10 cases,the "beak" signs in 10 cases,the "shoulder" signs in 15 cases and the "umbrella" signs in 18 cases.Conclusions: Long and narrow pyloric tubes and compression of hypertrophic pyloric cycliemusculic are reliable signs for diagnosis of CHPS.
Objective: To evaluate X-ray examination in diagnosis of congenital hypertrophic pyloric stenosis(CHPS).Methods: Twenty cases with CHPS confirmed by surgery and histopathology in our hospital during 2008 to 2009 underwent X-ray examination,and the X-ray manifestation was analyzed retrospectively.Results: Stomach dilatation was observed in 20 cases,stomach emptypostpone in 20 cases and gastro-esophageal hernia in 8 cases.The "line" signs in 20 cases,the "double-track" signs in 10 cases,the "beak" signs in 10 cases,the "shoulder" signs in 15 cases and the "umbrella" signs in 18 cases.Conclusions: Long and narrow pyloric tubes and compression of hypertrophic pyloric cycliemusculic are reliable signs for diagnosis of CHPS.
2009, 34(11): 1014-1015.
Abstract:
Objective: To evaluate thermal texture maps(TTM) in diagnosis of breast mass.Methods: Fifty-nine cases with breast tumor was determined by TTM,and the result was compared with that by color Doppler or Hr87-Ⅰ cold light source equipment.Results: Among the 59 cases,46 were proved to be benign tumors and 13 cases malignant tumors.And the detection rates of benign tumors were 95.65%by TTM,91.30% by color Doppler(P>0.05) and 80.43% by cold light source equipment(P<0.05),respectively.The detection rates of the malignant tumor were 92.31% by TTM,76.92% by color Doppler(P>0.05) and 46.15% by cold light source equipment(P<0.05),respectively.Conclusions: TTM is equivalent with color Doppler in diagnosis of breast tumor,and it is especially effective in differentiating benign and malignant breast tumors.
Objective: To evaluate thermal texture maps(TTM) in diagnosis of breast mass.Methods: Fifty-nine cases with breast tumor was determined by TTM,and the result was compared with that by color Doppler or Hr87-Ⅰ cold light source equipment.Results: Among the 59 cases,46 were proved to be benign tumors and 13 cases malignant tumors.And the detection rates of benign tumors were 95.65%by TTM,91.30% by color Doppler(P>0.05) and 80.43% by cold light source equipment(P<0.05),respectively.The detection rates of the malignant tumor were 92.31% by TTM,76.92% by color Doppler(P>0.05) and 46.15% by cold light source equipment(P<0.05),respectively.Conclusions: TTM is equivalent with color Doppler in diagnosis of breast tumor,and it is especially effective in differentiating benign and malignant breast tumors.
2009, 34(11): 1016-1018.
Abstract:
Objective: To assess the clinical value of chemotherapeutic renal artery embolization before radical nephrectomy in treatment of renal carcinoma.Methods: Clinical data were retrospectively analyzed in 17 cases of renal carcinoma who were treated with chemotherapeutic renal artery embolization by ultraliquified iodipin and gelatin sponge under digital subtraction angiography(DSA) before radical nephrectomy.Results: Seventeen cases the preoperative embolizations of renal artery were successfully performed.After renal artery embolization,the surgical resections revealed that the operation field was clear,the lumps were easily to peel off with less bleeding.The histopathology demonstrated that the tumors had obvious necrosis and the borderline with peripheral normal tissues was clear.Conclusions: Embolization of renal artery is effective and safe in treatment of renal carcinoma.Chemotherapeutic renal artery embolization before radical nephrectomy in renal carcinoma can greatly decrease the risk in the operation.Renal artery embolization shoud be widely applied for renal carcinoma.
Objective: To assess the clinical value of chemotherapeutic renal artery embolization before radical nephrectomy in treatment of renal carcinoma.Methods: Clinical data were retrospectively analyzed in 17 cases of renal carcinoma who were treated with chemotherapeutic renal artery embolization by ultraliquified iodipin and gelatin sponge under digital subtraction angiography(DSA) before radical nephrectomy.Results: Seventeen cases the preoperative embolizations of renal artery were successfully performed.After renal artery embolization,the surgical resections revealed that the operation field was clear,the lumps were easily to peel off with less bleeding.The histopathology demonstrated that the tumors had obvious necrosis and the borderline with peripheral normal tissues was clear.Conclusions: Embolization of renal artery is effective and safe in treatment of renal carcinoma.Chemotherapeutic renal artery embolization before radical nephrectomy in renal carcinoma can greatly decrease the risk in the operation.Renal artery embolization shoud be widely applied for renal carcinoma.
2009, 34(11): 1018-1020.
Abstract:
Objective: To evaluate three-phase spiral CT contract-enhanced(CE) scan in the diagnosis of carcinoma of pancreatic body and tail and its clinical application.Methods: Thirty-two cases with carcinomas of pancreatic body and tail underwent plain CT and three-phase CE scan.The CT value of normal pancreas and tumors were measured and compared.According to CT findings,the diagnosis and resectablities were assessed.Results: Among 32 cases,22 showed slight enhancement,9 showed middle enhancement,1 showed non-enhancing cystic lesion.Turmor-pancrea contrast values in arterical phase were 23.45±12.62,64.53±27.34 in pancrdatic parenchymal phase and 41.28±19.12 in portalvein phase.The datas of three groups have difference in statistics(P<0.01).Conclusions: Multislice spiral CT three-phase CE scan is valuable in detecting the carcinoma of pancreatic body and tail.
Objective: To evaluate three-phase spiral CT contract-enhanced(CE) scan in the diagnosis of carcinoma of pancreatic body and tail and its clinical application.Methods: Thirty-two cases with carcinomas of pancreatic body and tail underwent plain CT and three-phase CE scan.The CT value of normal pancreas and tumors were measured and compared.According to CT findings,the diagnosis and resectablities were assessed.Results: Among 32 cases,22 showed slight enhancement,9 showed middle enhancement,1 showed non-enhancing cystic lesion.Turmor-pancrea contrast values in arterical phase were 23.45±12.62,64.53±27.34 in pancrdatic parenchymal phase and 41.28±19.12 in portalvein phase.The datas of three groups have difference in statistics(P<0.01).Conclusions: Multislice spiral CT three-phase CE scan is valuable in detecting the carcinoma of pancreatic body and tail.
2009, 34(11): 1021-1023.
Abstract:
Objective: To explore the relationship between the expression of T-bet gene in peripheral blood mononuclear cells(PBMC) and pathogenesis of aplastic anemia(AA).Methods: T-bet mRNA expression in PBMC was semi-quantitatively analyzed by the reverse transcription PCR(RT-PCR) and the serum level of interferon-γ(IFN-γ) was detected by ELISA in total 37 cases,including 17 cases of the firstly diagnostic patients with AA,and 20 healthy individuals as controls.Results: As compared with those in normal control group,the expression of T-bet in PBMC and the serum level of IFN-γ in the firstly diagnostic patients with AA increased with significant difference(P<0.01),the correlativity of them appeared positive(P<0.05).Conclusions: The increased expression of both T-bet and IFN-γ may play an important role in immunopathology of AA.
Objective: To explore the relationship between the expression of T-bet gene in peripheral blood mononuclear cells(PBMC) and pathogenesis of aplastic anemia(AA).Methods: T-bet mRNA expression in PBMC was semi-quantitatively analyzed by the reverse transcription PCR(RT-PCR) and the serum level of interferon-γ(IFN-γ) was detected by ELISA in total 37 cases,including 17 cases of the firstly diagnostic patients with AA,and 20 healthy individuals as controls.Results: As compared with those in normal control group,the expression of T-bet in PBMC and the serum level of IFN-γ in the firstly diagnostic patients with AA increased with significant difference(P<0.01),the correlativity of them appeared positive(P<0.05).Conclusions: The increased expression of both T-bet and IFN-γ may play an important role in immunopathology of AA.
2009, 34(11): 1026-1028.
Abstract:
Objective: To provide a good basis for the judgement,classification and treatment of snoring and sleep apnea syndrome's diagnosis through the monitoring of polysomnography.Methods: The patients were monitored by polysomnography respiratory monitoring system.The time was not less than seven hours at night.Results: Three patients with primary snoring and sixty patients with sleep apnea syndrome(51 cases of seriousness,6 cases of secondary,3 cases of light) who received the sleep monitoring and treatment of pressure titration at the same time all had satisfactory results.Conclusions: Using polysomnographic monitoring timely is useful for diagnosis,treatment of sleep disorders.The patient will have a better understanding of their own disease,they would accept more active treatments and their quality of life will be improved.
Objective: To provide a good basis for the judgement,classification and treatment of snoring and sleep apnea syndrome's diagnosis through the monitoring of polysomnography.Methods: The patients were monitored by polysomnography respiratory monitoring system.The time was not less than seven hours at night.Results: Three patients with primary snoring and sixty patients with sleep apnea syndrome(51 cases of seriousness,6 cases of secondary,3 cases of light) who received the sleep monitoring and treatment of pressure titration at the same time all had satisfactory results.Conclusions: Using polysomnographic monitoring timely is useful for diagnosis,treatment of sleep disorders.The patient will have a better understanding of their own disease,they would accept more active treatments and their quality of life will be improved.
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