• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊

2009 Vol. 34, No. 12

Display Method:
The influence of cytoplasmic Ca2+ elevation on spike encoding at cerebellar Purkenje cells in mice
HUANG Li, ZHAO Shi-Di, GE Min, WANG Jin-Hui
2009, 34(12): 1053-1056.
Abstract:
Objective: To study the changes of the intrinsic electrophysiological characteristics of cerebellar Purkinje cells during the stage of the elevation of intracellular Ca2+ through micro-injected of IP3 receptor excitomotor of Purkinje cells in cerebellar vermis.Methods: The sagittal slices of cerebellar vermis(400 μm) were prepared.The recordings of threshold potential of firing spike and absolute refractory period following each spike of cytoplasmic Ca2+ elevation cells were conducted in whole-cell model with an Axoclamp-2B amplifier;and electrical signals were inputted into pClamp 9.2 for data acquisition and analysis of inter-spike interval and standard deviation of spike timing.The changes in the intrinsic electrophysiological properties at Purkinje neurons during the elevation of intracellular Ca2+ were examined.Results: Shortly after the elevation of intracellular Ca2+,compared with before,refractory period of sequential spikes was shorten,the threshold potential of firing spikes was lower(P<0.001).Conclusions: The elevation of cytoplasmic Ca2+ alters the refractory period and threshold potential of sequential spikes,leads to increase of the excitability and deteriorated spike encoding of cerebellar Purkinje cells.
Study on the relationship between newborn mouse interstitial pneumonia and Ureaplasma urealyticum vertical infection
LÜ Jie, LI Feng-yun, TANG Su-lan
2009, 34(12): 1057-1059.
Abstract:
Objective: To observe the relationship between newborn mice interstitial pneumonia and Ureaplasma urealyticum(UU) infection during the period of pregnancy of a vertical transmission animal model by genital infection with UU during the course of cyesis.Methods: Pregnant mice were infected by blood serum type 4 UU through vagina,interstitial pneumonia and settlement of UU in the newborn mice were observed by the methods of UU culture,pathology and immunohistochemical staining test;at the same time,control group was established.Results: Pathological examination showed that interstitial pneumonia occurred in the newborn mice of experimental group and its spleen had multinucleated giant cell,the lung and spleen of newborn mice had field planting of UU by etiology examination.In experimental group,UU positive detection rates in 356 neonatal mice lung and spleen were 33.34% and 71.36%,respectively;while UU were not detected in cultures from 378 above-mentioned tissues in control group;there were also plenty of UU antigen in the lung and spleen of newborn mice by immunohistochemical staining test;while control group had no phenomenon.Conclusions: The experiment demonstrates that the infection of UU during the period of pregnancy could influence embryonic development through vertical infection and result in newborn interstitial pneumonia.
Macrophage apoptosis induced by short-chain fatty acid stressed Salmonella typhi
LIU Ting-ting, MA Li-na, LI Feng-yun, FAN Rong
2009, 34(12): 1060-1062.
Abstract:
Objective: To compare the difference of the apoptosis of macrophage induced by Salmonella typhi(S.typhi) and that treated by short-chain fatty acid(SCFA).Methods: The apoptosis ratio of macrophage at different times after infection with S.typhi or its SCFA forms were determined by flow cytometry.Results: Both S.typhi and its SCFA forms induced apoptosis of the macrophage with significant difference in the rates of apoptosis compared with those of the control(P<0.01).However,the rate of apoptosis induced by SCFA forms was obviously higher than that by S.typhi(P<0.01).Conclusions: SCFA may promote the apoptosis of macrophage.
Morphologic relationship between precentral sulcus and its adjacent sulcus on MRI
ZHANG Shun-hua, WANG Zhen-huan, ZHANG Jun-xiang, SHEN Long-shan, ZHANG Lei, ZHANG Yan, LIU Zhi-jun
2009, 34(12): 1063-1066.
Abstract:
Objective: To investigate the morphologic relationship between the precentral sulcus(PreCS) and its adjacent sulcus on the axial and sagittal MRI of the brain.Methods: The continuous axial and sagittal MRI based on AC-PC line in 30 normal adult heads were obtained to identify,localize and classify the cerebral PreCS using the eFilm Workstation 2.1 and Adobe Photoshop 8.0 software in the microcomputer.The morphologic relationship between the PreCS and its adjacent sulcus were studied.Results: The PreCS intersected the cerebral longitudinal fissure in the shape of "Y",and the detection rate of MRI was 8.33%;the PreCS intersected the superior frontal sulcus,the middle frontal sulcus and the inferior frontal sulcus in the shape of inverted "Y",and the detection rates of MRI were 90.00%,3.33%,and 76.67%,respectively;the PreCS was not only parallel to the central sulcus,but also intersected the CS,and the detection rates of MRI were 83.33% and 16.67%,respectively;the PreCS intersected the lateral fissure in the shape of inclined "Y",and the detection rate of MRI was 80.00%;the PreCS was parallel to the anterior ascending ramus of lateral fissure,and the detection rate of MRI was 98.33%.Conclusions: The results may provide sectional-imaging anatomical basis for the level diagnosis,stereotactic and minimally invasive neurosurgery in the PreCS neighboring areas.
2009, 34(12): 1066-1066.
Abstract:
Repair of head and neck defects with neck flap or pectoralis major myocutaneous flap: an analysis of 19 cases
PENG De-feng, WANG Sheng-ying, ZHU Zheng-zhi, MA Xiao-kai
2009, 34(12): 1067-1069.
Abstract:
Objective: To explore the clinical effect of repairing postoperative head and neck neoplasm defect with neck flap or pectoralis major myocutaneous flap.Methods: Nineteen cases of head and neck neoplasm defect were repaired with pectoralis major myocutaneous flap or neck flap.Results: All the muscular flaps survived,with a success rate of 100%.The appearance satisfaction reached 84.21%(16/19) and the function satisfaction 89.47%(17/19).All the patients were followed up for 3-8 years.Three-year survival rate was 63.16%(12/19) and 5-year survival rate was 41.18%(7/17).Conclusions: The pectoralis major myocutaneous flap and neck flap are easy to prepare and present a high survival rate.It is preferred for the reconstruction of head and neck neoplasm defect.
The observation of sevoflurane compound with propofol for anaesthesia in children minimally invasive heart surgery
LI Xiao-hong, LIU Jun, LING Yun-zhi
2009, 34(12): 1070-1072.
Abstract:
Objective: To observe the feasibility of sevoflurane compound with propofol for anaesthesia used in children minimally invasive heart surgery.Methods: Fifty-six cases of children were undertaken intracardiac procedures with cardiopulmonary bypass.These cases were inducted with 4%-6% sevoflurane and O2 inhalation,5 μg/kg of fentanyl and 0.06 mg/kg of midazolam through intravenous injection,vecuronium at 0.15 mg/kg were used in sequences for anaesthesia.Adopted 1.0%-2.5% sevoflurane inhalation compound with fentanyl and vecuronium to keep a good anaesthesia condition.Results: Fifty-six cases were kept a good anaesthesia effect which the process is steady,and blood pressure and heart rate were maintained steadily during operation(P>0.05).Mean arterial pressure(MAP),heart rate(HR) in post-CPB 1 minute,20 minutes were significantly lower than in pre-CPB(P<0.01).But MAP and HR in CPB shutdown compared with in pre-CPB no significant difference(P>0.05).The anaesthetizes relevant complications were not appeared after operation.Conclusions: Sevoflurane compound with propofol for anaesthesia can meet the demand in children minimally invasive heart surgery which is steadily and rapidly,and the anaesthesia profundity can be well controlled.
Bladder inflammatory myofibroblastic tumor: report of 4 cases and review of the literatures
YU Bao-zhu, LI Qing-wen, WANG Cheng-yong, ZHANG Jia-jun
2009, 34(12): 1073-1075.
Abstract:
Objective: To investigate the clinical and pathological characteristics,the treatment and prognosis of inflammatory myofibroblastic tumor(IMT) by reviewing the literatures.Methods: The clinical data and pathological characteristics of 4 cases of IMT treated were analyzed retrospectively,and the literatures were reviewed.Results: All the 4 cases received supersonic wave and cystoscopy.Three cases were diagnosed as cystitis possible,and bladder tumor could not be precluded;1 case was reported to be bladder IMT.Four cases underwent partial resection of the bladder and all were confirmed to be IMT by pathology.Up to now,3 cases had no relapse,and 1 case was followed up no longer than 7 months.Conclusions: The clinical feature of bladder IMT resembles that of bladder tumor.Final diagnosis relies on immunohistochemical method.Surgical operation is the best procedure for the treatment of the disease.
Improved percutaneous transhepatic biliary drainage for treatment of malignant obstructive jaundice: a report of 116 cases
ZHOU Lei, LIU Hui-chun, LI Zong-kuang, ZHOU Shao-bo, SUN Yi-xue
2009, 34(12): 1075-1077.
Abstract:
Objective: To explore the clinical application of improved percutaneous transhepatic biliary drainage(PTBD) in treatment of malignant obstructive jaundice.Methods: The clinical data of 116 cases of malignant obstructive jaundice were analyzed retrospectively.Improved PTBD was carried out for all the patients including 37 cases of pancreatic head carcinoma,23 cases of ampulla carcinoma,30 cases of hilar cholangiocarcinoma and 26 cases of metastatic carcinoma.Results: The improved PTBD was successful in 113 patients(97.4%).Among them,the PTBD tube was placed in the common hepatic duct in 42 cases,in the right hepatic duct in 44 cases,in the left hepatic duct in 22 cases and in both the left and the right hepatic duct in 5 cases.The signs of jaundice,skin itch,mode and appetite were greatly improved one week after the operation.The serum bilirubin decreased from 101.2-592.8 μmol/L to 24.9-278.3 μmol/L one week after the treatment.No severe complications were observed.Conclusions: The improved PTBD proves to be safe and effective for treatment of malignant obstructive jaundice,and it makes the further treatment possible.
Correlations of serum PA,Hs-CRP,CRP in premature infants with gestational age and premature rupture of fetal membranes
WANG Su-mei, XU Bing, CHEN Jian-wen
2009, 34(12): 1078-1080.
Abstract:
Objective: To investigate the correlations of serum prealbumin(PA),highly sensitive C reactive protein(Hs-CRP) and C reactive protein(CRP) in premature infants with the gestational age and premature rupture of membranes.Methods: Serum PA,Hs-CRP and CRP of 80 preterm infants who were born within 48 hours,and had an affirmed gestation age and birth history were detected within 24-48 hours after birth;the relevant clinical data including gestation age,premature rupture of membrane and the time of premature rupture of membrane were recorded.Results: Serum PA,Hs-CRP and CRP in the premature infants with a gestation age of less than 32 weeks,32-33+6 weeks and 34-36+6 weeks had no statistical difference(P>0.05).Serum PA levels in cases with no premature rupture of membrane,or the time of membrane rupture less than 6 hours,6-24 hours and more than 24 hours before birth have no statistical difference(P>0.05),while serum Hs-CRP and CRP levels were statistically different(P<0.05 to P<0.01).Serum Hs-CRP and CRP levels in cases with membrane rupture above 24 hours before birth were obviously higher than those in other groups(P<0.05 to P<0.01).Conclusions: Serum PA,Hs-CRP and CRP levels in preterm infants have no correlation with the gestation age.Serum Hs-CRP and CRP levels are related to the premature rupture of membrane and the time of premature rupture of membrane;serum Hs-CRP and CRP levels in cases with membrane rupture above 24 hours before birth increase significantly;serum PA levels are not concerned with the premature rupture of membrane or the time of premature rupture of membrane.
Value of level Ⅲ lymph node dissection for breast cancer and its clinical application
JIN Gong-sheng, HAN Fu-sheng, LI Hong-tao, YU Da-jun, GUO Wei
2009, 34(12): 1081-1083.
Abstract:
Objective: To explore the value of dissection of level Ⅲ lymph nodes for breast cancers and the operation skills.Methods: The Kodama was used to dissect level Ⅰ-Ⅲ axillary lymph nodes of 38 patients with breast cancer and the Auchincloss was used to dissect level Ⅰ-Ⅱ axillary lymph nodes of 40 patients with breast cancer.The postoperative complications were analyzed comparatively.Results: The metastasis rate of level Ⅲ axillary lymph nodes was 25 percent in patients with level Ⅰ-Ⅱ axillary node metastasis.There was no difference in surgical complications(skin flap necrosis,lymph fistula and pectoralis major atrophy) (P>0.05),but the difference was significant in operation time(P<0.01).Conclusions: It is reasonable to dissect level Ⅲ axillary lymph nodes for the patients with levelⅠ-Ⅱ axillary node metastasis.The Kodama is a recommendable method for dissection of level Ⅲ axillary lymph nodes.
Surgical treatment for large bowel obstruction caused by colorectal carcinoma: a report of 56 cases
ZHENG Yu-qiang, QI Liang-bi, FANG Shou-jun
2009, 34(12): 1083-1084.
Abstract:
Objective: To study the effect of surgical therapy on large bowel obstruction caused by colorectal carcinoma.Methods: Fifty-six patients with large bowel obstruction caused by colorectal carcinoma were treated by surgery,and the results were analyzed retrospectively.Results: Among the 56 cases,10 were performed right hemicolectomy,4 transvercolectomy,and 40 left hemicolectomy,proximal colon fistulization or distal colon closure.Two cases whose rectum carcinoma couldn't be removed underwent sigmoid fistulization.The perioperative mortality rate was 3.6%(2/56),and the rest recovered well.Conclusions: Early diagnosis,rational selection of surgical procedures and appropriate perioperative management may reduce the complications and mortality rate in treatment of large bowel obstruction caused by colorectal carcinoma.
Effect of different hemodialysis methods on eliminating serum bone gla-protein,calcitionin,parathormone and β2-microglobulin in patients with chronic renal disease
MA Sheng-yin, LIU Chao-yang
2009, 34(12): 1085-1087.
Abstract:
Objective: To explore the change rule of bone gla-protein(BGP),calcitionin(CT),parathormone(PTH) and β2-microglobulin(β2-BG) in serum of 30 patients with chronic renal disease(CRF) by different hemodialysis methods,and compare the therapy effect between low-flux hemodialysis(LFHD) and high-flux hemodialysis(HFHD).Methods: Thirty cases of chronic hemodialysis patients were divided into HFHD group(12 cases) and LFHD group(18 cases),they were followed up for 4 weeks.The variation of serum levels of BGP,CT,PTH,β2-MG in CRF patients were analyzed by radioimmunoassay and chemiluminescent detection methods before and 4 week after hemodialysis.Results: The levels of BGP,PTH,β2-MG and P3- in serum of patients with CRF were higher than those of the controls(P<0.01),but the levels of CT and Ca2+ were lower than that of the controls(P<0.01 and P<0.05) significantly;the level of β2-MG was increased in LFHD group while decrease in HFHD group,and the levels of BGP and PTH were decreased significantly in HFHD group(P<0.01).CT level was increased in LFHD group while decreased in HFHD group(P<0.01).The levels of PTH and β2-MG were markedly reduced when post-dialysis and 4 weeks after dialysis comparing to those of pre-dialysis(P<0.01).The symptoms such as shin pitch,arthralgia,muscle spasm and so on in HFHD group were significantly ameliorated.Conclusions: There was a significant clinical value in testing serum BGP,CT,PTH and β2-MG concentrations for analyzing patients condition,assessing the treatment effect and estimating prognosis of patients with CRF.The efficacy of HFHD is better than that of LFHD.
Surgical therapy for post-operative intraabdominal hemorrhage in patients with severe liver trauma: a report of 18 cases
WANG Zhun, ZHU Chun-fu, JIN Kun
2009, 34(12): 1088-1090.
Abstract:
Objective: To sum up the experience in treating post-operative intraabdominal hemorrhage in patients with serve liver trauma by surgery.Methods: A total of 18 cases of post-operative re-hemorrhage that had been first operated on for severe liver trauma from 1999 to 2008 in our hospital were analyzed retrospectively.Results: According to AAST Classification,all the cases had trauma of degree Ⅲ or above.The post-operative intraabdominal hemorrhage of the patients reached 800-1 700 ml,and all received re-operation.Of the 18 cases,14 were cured and 4 died.The mortality rate was 22.22%.Conclusions: Timely re-operation is effective for treatment of post-operative intraabdominal hemorrhage in patients with severe liver trauma.It is essential to select appropriate operation methods in accordance to the condition of the patients.
CT-guided drainage plus sclerotherapy for great renal cysts: a report of 10 cases
LIU Xi-zhen, HUANG Yong-bin, LI Qing-wen
2009, 34(12): 1090-1091.
Abstract:
Objective: To observe the clinical effect of CT-guided drainage plus sclero-therapy on great renal cysts.Methods: Ten cases of great renal cysts with a diameter of 8 cm or more were punctured 7F tubes for drainage under the guidance of CT,and ethanol was injected regularly for sclerotization.After each injection,the tube was clipped for 1 to 2 hours before drainage.B mode ultrasound was performed regularly,and the time to extract the tube was decided according to the amount of drainage.Results: B mode ultrasound showed that all the 10 cases of great renal cysts were cured three months after the therapy.Conclusions: CT-guided drainage plus sclero-therapy is safe and effective for treatment of great renal cysts.
Ginsenoside Rg3 capsules combined with FOLFOX4 regimen for treatment of advanced colon cancer: a report of 35 cases
ZENG Dong-xiang, LING Yang, YANG Quan-liang, SUN Yi
2009, 34(12): 1092-1094.
Abstract:
Objective: To observe the effect,adverse reaction and cytoimmunity function of ginsenoside Rg3 capsules combined with FOLFOX4 regimen in treatment of advanced colon cancer.Methods: Sixty-seven patients were randomly divided into two groups.Group A(32 cases) received FOLFOX4 regimen only,and Group B(35 cases) were treated with ginsenoside Rg3 capsules plus FOLFOX4 regimen.Results: The response rate was 40.6% in group A and 45.7% in group B(P>0.05).A lower response rate of leucopenia occurred in group B compared with that in group A(P<0.05-P<0.01).The difference was significant in the elevation of T lymphocyte subset and life quality between the two groups.Conclusions: Ginsenoside Rg3 capsules can decrease the side effects of chemotherapy and improve the immunity and life quality of the patients with advanced colon cancer.
Application of neck dissection preserving cervical plexus nerve in differentiated thyroid cancer
MA Cheng-quan, ZHANG Xing-hai
2009, 34(12): 1095-1096.
Abstract:
Objective: To explore the clinical application of neck dissection preserving cervical plexus nerve in thyroid cancer.Methods: The neck dissection preserving cervical plexus nerve was performed in 27 patients with differentiated thyroid cancer,and the clinical effect was observed.Results: No impairment of sensation of ears,lower necks or shoulders were found in all the 27 patients,and no recurrence of lymph node of neck was observed during the follow-up of one to three years.Conclusions: The neck dissection preserving cervical plexus nerve can improve the life quality of the patients without increasing the recurrence rate of lymph node of neck.
Relationship between J wave and ventricular tachycardia in patients with acute myocardial infarction
LU Jiang-hui, LI Yu-jie, LI Jing-jing, FENG Yan-xian
2009, 34(12): 1097-1098.
Abstract:
Objective: To observe the influence of J wave on ventricular tachycardia in patients with acute myocardial infarction.Methods: The electrocardiogram of 113 patients who were hospitalized less than six hours was retrospectively analyzed.The patients were divided into J wave group(43 cases) and non J wave group(70 cases).The static electrocardiogram of the two groups was recorded and the ventricular tachycardia rates were compared.Results: Ventricular tachycardia rates were significantly higher in the J wave group than in the non J wave group(P<0.05).Conclusions: The ventricular tachycardia rate is increased in patients with acute myocardial infarction accompanied by J ware,indicating that their electrocardiogram is more likely to be unstable.
Testicular torsion: clinical analysis of 16 cases
SANG Shi-fang, GE Qing-sheng, XU Peng-cheng
2009, 34(12): 1099-1100.
Abstract:
Objective: To explore the diagnosis and treatment of testicular torsion so as to improve the efficacy treatment.Methods: The clinical data,including the onset,treatment and prognosis of 16 cases of testicular torsion were reviewed.The age of the patients ranged from 13-42 years.Results: Eleven cases had left side testicular torsion and 5 cases the right side.The elapse of time from onset to definite diagnosis was 2 h-8 d.The diagnosis of testicular torsion in 15 cases was based on color Doppler flow imaging(CDFI) and 1 case was verified by operation.All the 16 cases underwent acute operation.Twelve cases of testicles were removed for necrosis,and only 4 cases of testicles were salvaged by operative detorsion.Conclusions: Early diagnosis of testicular torsion is very important,and CDFI is reliable for diagnosis of testicular torsion.Immediately operation after admission is essential for salvage of the testicle.
Biliary tract complications following orthotopic liver transplantation: an analysis of 3 cases
MA Liang-long, ZHANG Shu-min
2009, 34(12): 1101-1102.
Abstract:
Objective: To explore the causes of biliary tract complication following orthotopic liver transplantation(OLT).Methods: The clinical data of 3 patients suffering from biliary tract complications after OLT were retrospectively analyzed.Results: The biliary tract complications occurred 1 to 3 months after OLT.The mean cold and warm ischemic time were 8.5 hours and 3 minutes respectively.Virus infection occurred in one case and acute rejection occurred in one case after transplantation.Conclusions: Many factors are responsible for biliary tract complications.The main causes are inadequate blood supply,ischemic reperfusion injury,viral infection and rejection.
Study on the incident and clinical features of hypernatremia in severe stroke
LU Jing-hong, ZHOU Ying, LI Zong-you, WANG You-meng, SHANG Zhi-hong, XU Jing, RU Ning, ZHANG Yan, YANG Cheng
2009, 34(12): 1103-1105.
Abstract:
Objective: To study the incidence rate and clinical features of hypernatremia in severe stroke and provide the evidences for therapy.Methods: The clinical data and clinical prognosis of 156 admitted patients with severe stroke were analyzed retrospectively.The incidence rate of hypernatremia in 24 hours,>24 to 72 hours and >72 hours to 1 week were analyzed.The relationships between hypernatremia and the types of stroke,focus places,the neurological deficit and clinical prognosis were also analyzed.Results: Among all patients 25 patients were accompanied with hypernatremia,the incidence rate of hypernatremia was 16.03%.Sixteen patients with hypernatremia were happened in 72 hours after stroke,and 2 patients were accompanied with severe hypernatremia.And the iatrogenic factor maybe was the main risk factor.Nine patients with hypernatremia were happened after 72 hours,of which 5 patients were accompanied with severe hypernatremia.Hypernatremia had the relationship with focus places of stroke(especially in brainstem,thalamus and cerebellum),the neurological deficit and prognosis(P<0.05-P<0.01),and had no relationship with types of stroke(P>0.05).Conclusions: The iatrogenic factor and the injury on brainstem,thalamus and cerebellum are the reasons for hypernatremia after stroke.The emergence of hypernatremia is considered as an important index which estimates the state of stroke and clinic prognosis.
Calcium gluconate combined with modified FOLFOX4 regimen for treatment of advanced gastric and colorectal carcinoma
SHENG Gui-feng, BI Yan-zhi, DONG Yi-zhong, ZHANG Ya-ping, SONG Hong-lei, XU Jian-zhong
2009, 34(12): 1106-1108.
Abstract:
Objective: To assess the neuroprotectant effect of Calcium gluconate combined with modified FOLFOX4 regimen on oxaliplatin-induced neurotoxicity.Methods: One hundred and ninety-six patients were randomly divided into two groups.Group A were administered modified FOLFOX4 regimen and Calcium gluconate.They were administered infusion of 5% Calcium gluconate(1 g) before and after oxaliplatin,and the regimen was repeated every two weeks.Group B received modified FOLFOX4 regimen only.Results: The response rate was 45.88%(39/85) and 46.85%(52/111) in group A and group B respectively(P>0.05),and the incidence of neurotoxicity was 49.41% and 65.77% in group A and group B respectively(P<0.05).Conclusions: Infusion of Calcium gluconate can effectively reduce the incidence of oxaliplatin-induced neurotoxicity without interfering the effect of modified FOLFOX4 regimen.
Ulinastatin for treatment of acute lung injury/acute respiratory distress syndrome: an analysis of 34 cases
ZHANG Bao-min, SUN Yan, XU Ji-lai, PAN Li-ping
2009, 34(12): 1108-1110.
Abstract:
Objective: To observe the therapeutic effect of ulinastatin on acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Methods: Thirty-four patients with ALI/ARDS were randomly divided into treatment group(n=17) and control group(n=17).The control group received only the routine therapy,and the treatment group were given ulinastatin(200 ku intravenously,once every 8 hours,and continued for 10 days) in addition to the routine treatment.The efficacy was assessed in both groups.The parameters of heart rate,respiratory rate,oxygenation,average arterial blood pressure and arterial blood gas were monitored.Serum levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1) and IL-6 were measured on admission,the day 4 and the day 7 in both groups.Results: Before treatment,the TNF-α,IL-1 and IL-6 levels were not significantly different between the ulinastatin group and the control group(P>0.05);but descended significantly after treatment in the ulinastatin group(P<0.01),as well as the respiratory rate,heart rate,and the average arterial blood pressure.The blood gas analysis proved that PaO2 and PaO2/FiO2 increased significantly in the treatment group compared with those in the comparison group(P<0.01).Conclusions: Ulinastatin may significantly inhibit the production of inflammatory cytokinases and thus prevent the systemic injury by inflammatory response and improve the prognosis of ALI/ARDS.
Strauss classify screen and therapy strategy for keeping limbs of diabetic foot
HANG Yuan-ying, YUAN Peng, ZHOU Yue, YANG Yu-sheng
2009, 34(12): 1111-1112,1115.
Abstract:
Objective: To investigate the selection of screen and therapy methods for diabetic foot in keeping limbs therapy.Methods: Sixty cases of diabetic foot were screened by Strauss classify,the A and B stage binding with pathological characters were divided into diabetic ischemia foot ulcer,diabetic neuropathy foot and diabetic foot concurrent infection and so on,the different combined therapies were used to them.Results: Eleven cases belonged to A stage were all healed.Forty-four cases were belonged to B stage,39 of them were successfully healed,3 of the pathogenetic condition were repeated and were delayed healing for 2 months,2 of pathogenetic condition delayed and couldn't be healed,for 3 months,then amputation was used in middle and superior segment of upper leg.Five belonged to C stage were all amputated.The total keeping limbs rate was 88.4%.Conclusions: Strauss classify is a simple and useful method which is fully distinct for judging the prognosis of diabetic foot.The classic therapy can get to the healing purpose,the new therapies still can't be extensively carried out in present.
Community-based comprehensive intervention in aiding high blood pressure patients to reach target blood pressure
LIU Jie, PAN Xue-lan, KUANG Yu-yan
2009, 34(12): 1113-1115.
Abstract:
Objective: To assess the role of community-based comprehensive intervention in helping patients with high blood pressure(HBP) to reach target blood pressure.Methods: Five hundred and sixty subjects with hypertension were enrolled in the study,consisting of 280 outpatients and 280 community patients.The outpatients were given only the regular therapy to control the blood pressure,while the community patients received comprehensive intervention therapy including health education,drug treatment,behavioral and psychological treatments,and social supervision.All the patients were followed up for six months,and then the rates of reaching target blood pressure were compared between the two groups.Results: The rate of reaching target blood pressure was significant higher in the community-based comprehensive intervention group than that in the outpatients(P<0.05).Conclusions: Community-based comprehensive intervention effectively enhances the patients cognition to the disease and increases the rate of reaching target blood pressure.
2009, 34(12): 1116-1117.
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2009, 34(12): 1117-1119.
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2009, 34(12): 1119-1120.
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2009, 34(12): 1121-1122.
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2009, 34(12): 1122-1122.
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Detection of DHA-1 plasmid-mediated AmpC β-lactamase of Pseudomonas aeruginosa
FAN De-sheng
2009, 34(12): 1123-1125.
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Objective: To investigate DHA plasmid-mediated AmpC β-lactamases in the clinical isolation of Pseudomonas aeruginosa(Pa) from patients in Huaibei Miner's General Hospital.Methods: Thirty-six Pa isolated from clinical specimens were collected and analyzed drug-resistance to clinical common antibiotics with K-B method,and detected the resistance phenotypes by modified three-dimensional test.After extraction of genomic DNA,DHA-1 gene was amplified by polymerase chain reaction(PCR) and sequenced.Homology analysis of these sequences was carried out by compared with DHA genes of enterobacteriaceae in gene bank.Results: DHA-1 gene was amplified by PCR in 69.4%(25/36) Pa isolations.The resistant rate of 25 Pa to 10 types of antibiotics was more than 50%,and ERIC-PCR analysis was shown DHA-1 was prevailed in the same or different departments in our hospital.Conclusions: The detection rate of DHA-1 is much higher than that in other regions;Pa isolated with DHA-1 gene showed powerful activities with resistance to cephalosporin and monocyclic lactam antibiotics.The prevalence of Pa in the same or different departments should be noted seriously.
Clinical significance of detecting C reaction protein and arterial blood-gas analysis in patients at the acute exacerbation of chronic obstructive pulmonary disease
GUANG Sheng-fang, ZHAO Xiang-ling
2009, 34(12): 1126-1127.
Abstract:
Objective: To explore the clinical value of detecting C reaction protein(CRP) and arterial blood-gas analysis(ABG) in patients at the acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods: The levels of CRP and ABG in 45 patients with AECOPD were detected before and after treatment,and the results were compared with those of 35 controls.CRP was determined with immune turbidimetry method,and ABG was detected by i-STAT blood-gas analyzer's performance.Results: The serum concentration of CRP of the AECOPD patients was higher than that of the control before and after treatment(P<0.01).After treatment,PaO2 in AECOPD patients increased significantly,while PaCO2 decreased(P<0.01).Conclusions: There are obvious changes of the serum concentrations of CRP,ABG in AECOPD patients before and after treatment.Serum concentration of CRP and ABG may act as indicators of curative effect and prognosis,which will provide some laboratory evidence for clinical assessment.
Low-field MRI in diagnosis of knee meniscus injuries
ZHENG Jian-gang, MEI Li, GU Yong-jian, SUN Xia-ping
2009, 34(12): 1128-1130.
Abstract:
Objective: To improve the diagnosis of knee meniscus injury with low-field MRI.Methods: Twenty patients with knee meniscus injures were examined by MRI.All the subjects were scanned by T1WI(SE) in coronal and cross-section,T2WI(SE) in cross-section,T2(dual-echo) and protron density weighted image in sagittal plane,and STIR in coronal plane.The knee meniscus injuries were divided into 0-3 levels by the MRI signal.Results: Of the forty knee meniscus injuries,thirty-four(85%) were diagnosed as level 3,four(10%) were diagnosed as level 2 and two(5%) were diagnosed as level 1.The morphous of injured knee meniscus was varied.High signals could be found in MRI and all were confirmed by operation.Conclusions: As long as the method is proper,low-field MRI can also diagnose meniscal injuries accurately.
2009, 34(12): 1130-1131.
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Reform and practice in teaching Environmental Hygiene
ZHEN Quan, ZHAO Yun-li, YANG Jing, ZHANG Jie, ZHOU Chun-xian
2009, 34(12): 1132-1134.
Abstract:
Objective: To improve the quality of teaching Environmental Hygiene cause.Methods: A series of measures were performed in class teaching with three aspects:optimizing teaching contents,improving teaching methods and ameliorating teaching means.As to experimental teaching,six subjects were integrated into experimental course of Preventive Medicine,and simulative scientific research experiments were developed actively.Results: Students' enthusiasms were aroused.Their knowledge level,innovation and practical abilities were elevated.Conclusions: Course reformation contributes to spark students' study interest,deepen their understanding of what they have learned,so that they are able to apply their knowledge to practice.Meanwhile,their capacity for analyzing and solving problems are promoted.
Bilingual teaching methods in Medical Immunology based on the characteristics of English vocabulary and terms in the specialty
QIAN Zhong-qing, WU Jun-ying, LI Xing-hua, GE Xiao-song, WANG Hong-tao, YAO Chun-yan, LI Bai-qing
2009, 34(12): 1135-1137.
Abstract:
Objective: To analyze the characteristics of English terms in the specialty of Medical Immunology and to explore the application of bilingual teaching method in the course of Medical Immunology.Methods: The characteristics of composition of English terms and abbreviations in Medical Immunology were analysed.The bilingual teaching methods,"Induction of terms","Extension of terms" and "Summary in terms" were designed and apllyied in the course of Medical Immunology.Results: Most of English terms in Medical Immunology are composed of common vocabulary common root and the prefix or suffix,or combined with,furthermore there are more abbreviations of terms and less the specialty specific terms,which is conducive to the bilingual teaching and learning.Through the implementation of bilingual teaching methods designed on the features of the English terminology,the students' understanding of the specialty terms and related concepts was promoted on the bilingual level,the good teaching efficacy was obtained.Conclusions: The bilingual teaching methods based on the characteristics of English terms Medical in Immunology are inducive to promote the teaching efficacy of the bilingual course of Medical Immuology.
2009, 34(12): 1137-1139.
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2009, 34(12): 1140-1141.
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2009, 34(12): 1141-1142.
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2009, 34(12): 1143-1144.
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2009, 34(12): 1145-1146.
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2009, 34(12): 1146-1148.
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2009, 34(12): 1148-1149.
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2009, 34(12): 1150-1151.
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2009, 34(12): 1151-1153.
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2009, 34(12): 1153-1155.
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2009, 34(12): 1155-1157.
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2009, 34(12): 1157-1157.
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2009, 34(12): 1158-1159.
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2009, 34(12): 1160-1161.
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2009, 34(12): 1162-1164.
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2009, 34(12): 1164-1166.
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2009, 34(12): 1166-1168.
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