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2009 Vol. 34, No. 6
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2009, 34(6): 461-463.
Abstract:
Objective: To study the changes of the intrinsic electrophysiological characteristics of cerebellar Purkinje cells and the possible mechanisms during the early stage of simulated ischemia by reducing the perfusion to the sagittal slices of cerebellar vermis in rat.Methods: The sagittal slices of cerebellar vermis(400 μm) were prepared.The recordings of threshold potentials of firing spikes and refractory periods following each spike of simulated ischemia cells were conducted in a whole-cell model with an Axoclamp-2B amplifier;and the electrical signals were input into pClamp 9.2 for data acquisition,analysis of inter-spike interval and standard deviation of spike timing,in order to detect the changes in the intrinsic electrophysiological properties at Purkinje neurons during the simulated ischemia.Results: Shortly after reducing the perfusion rate,refractory periods of sequential spikes were shortened and the threshold potentials of firing spikes lowered(P<0.01).Conclusions: The ischemia changes the refractory periods and the threshold potentials of sequential spikes,which causes over-excitation of cerebellar Purkinje cells and deteriorates spike encoding at cerebellar Purkinje cells.
Objective: To study the changes of the intrinsic electrophysiological characteristics of cerebellar Purkinje cells and the possible mechanisms during the early stage of simulated ischemia by reducing the perfusion to the sagittal slices of cerebellar vermis in rat.Methods: The sagittal slices of cerebellar vermis(400 μm) were prepared.The recordings of threshold potentials of firing spikes and refractory periods following each spike of simulated ischemia cells were conducted in a whole-cell model with an Axoclamp-2B amplifier;and the electrical signals were input into pClamp 9.2 for data acquisition,analysis of inter-spike interval and standard deviation of spike timing,in order to detect the changes in the intrinsic electrophysiological properties at Purkinje neurons during the simulated ischemia.Results: Shortly after reducing the perfusion rate,refractory periods of sequential spikes were shortened and the threshold potentials of firing spikes lowered(P<0.01).Conclusions: The ischemia changes the refractory periods and the threshold potentials of sequential spikes,which causes over-excitation of cerebellar Purkinje cells and deteriorates spike encoding at cerebellar Purkinje cells.
2009, 34(6): 464-467.
Abstract:
Objective: To investigate the function of NT21MP from human herpesvirus-8(HHV8) monocyte inflammatory protein(MIP) N-terminal peptide in resisting breast cancer.Methods: Breast carcinoma model mice were established by 4T-1 breast cancer cell strains.The models were divided into NT21 MP group(5μg/kg,50μg/kg and 500 μg/kg),combination therapy group(NT21MP 50 μg/kg + Herceptin 36.04 μg/kg).positive control group(Herceptin 36.04 μg/kg) and sodium chloride group.The size of the tumor on the tumor-bearing mice was observed,the tumor inhibitory rate was calculated and the metastasis lung node was detected.Results: Compared with the tumor-bearing mice in sodium chloride group,NT21 MP inhibited the growth of tumor in a dose-dependent manner,which was the most evident in the combination group(P < 0.01).The tumor inhibitory rates in the NT21MP groups with different concentrations,the combination group and the positive control group were 10.0%,41 6%,81.0%,58.2% and 39.2% respectively.Metastasis Lewis lung cancers were observed in both of the control groups,and several metastasis nodes of white tumor were observed on the surface of the mice's lung;and the situation was the same with NT21MP 5 μ/kg group.In NT21 MP 50 μg/kg group and Herceptin group,metastasis Lewis lung cancers were noted in the lungs of five sixths of the mice,and small and single metastasis node was found on the surface of the lung.In the NT21 MP 500 μg/kg group and the combination therapy group,metastasis Lewis lung cancers were noted in two sixths and three sixths of the mice,respectively,and no obvious metastasis nodes were found on the surface of the mice's lung.Conclusions: NT21MP may inhibit the growth and metastasis of breast cancer.Combination therapy of NT21 MP and the targeted drug Herceptin can improve the clinical efficacy.
Objective: To investigate the function of NT21MP from human herpesvirus-8(HHV8) monocyte inflammatory protein(MIP) N-terminal peptide in resisting breast cancer.Methods: Breast carcinoma model mice were established by 4T-1 breast cancer cell strains.The models were divided into NT21 MP group(5μg/kg,50μg/kg and 500 μg/kg),combination therapy group(NT21MP 50 μg/kg + Herceptin 36.04 μg/kg).positive control group(Herceptin 36.04 μg/kg) and sodium chloride group.The size of the tumor on the tumor-bearing mice was observed,the tumor inhibitory rate was calculated and the metastasis lung node was detected.Results: Compared with the tumor-bearing mice in sodium chloride group,NT21 MP inhibited the growth of tumor in a dose-dependent manner,which was the most evident in the combination group(P < 0.01).The tumor inhibitory rates in the NT21MP groups with different concentrations,the combination group and the positive control group were 10.0%,41 6%,81.0%,58.2% and 39.2% respectively.Metastasis Lewis lung cancers were observed in both of the control groups,and several metastasis nodes of white tumor were observed on the surface of the mice's lung;and the situation was the same with NT21MP 5 μ/kg group.In NT21 MP 50 μg/kg group and Herceptin group,metastasis Lewis lung cancers were noted in the lungs of five sixths of the mice,and small and single metastasis node was found on the surface of the lung.In the NT21 MP 500 μg/kg group and the combination therapy group,metastasis Lewis lung cancers were noted in two sixths and three sixths of the mice,respectively,and no obvious metastasis nodes were found on the surface of the mice's lung.Conclusions: NT21MP may inhibit the growth and metastasis of breast cancer.Combination therapy of NT21 MP and the targeted drug Herceptin can improve the clinical efficacy.
2009, 34(6): 468-470.
Abstract:
Objective: To investigate the role of baicalein in inhibiting the HeLa cells of human cervix cancer and the possible mechanism.Methods: Sulforhodamine B(SRB) assay was used to determine the inhibitory effect of baicalein on HeLa cell growth;cellular apoptosis was detected by Hoechst 33258 fluorescent staining;caspase-3 activity was assayed by colorimetric method.Results: After treated with different concentration of baicalein for 24,36,48 hour,HeLa cell growth were significantly inhibited(P<0.05 to P<0.01);the apoptosis rate of HeLa cells(P<0.01) and the activity of caspase-3(P<0.05 to P<0.01) were increased when HeLa cells were treated with baicalein for 24 hours.Conclusions: Baicalein can inhibit the growth of HeLa cells,and the inhibitory effect probably results from the increased cell apoptosis and caspase-3 activity.
Objective: To investigate the role of baicalein in inhibiting the HeLa cells of human cervix cancer and the possible mechanism.Methods: Sulforhodamine B(SRB) assay was used to determine the inhibitory effect of baicalein on HeLa cell growth;cellular apoptosis was detected by Hoechst 33258 fluorescent staining;caspase-3 activity was assayed by colorimetric method.Results: After treated with different concentration of baicalein for 24,36,48 hour,HeLa cell growth were significantly inhibited(P<0.05 to P<0.01);the apoptosis rate of HeLa cells(P<0.01) and the activity of caspase-3(P<0.05 to P<0.01) were increased when HeLa cells were treated with baicalein for 24 hours.Conclusions: Baicalein can inhibit the growth of HeLa cells,and the inhibitory effect probably results from the increased cell apoptosis and caspase-3 activity.
2009, 34(6): 471-472.
Abstract:
Objective: To acquire some relevant parameters of the lumbosacral anterior great vessels so as to provide theoretical basis for lumbosacral anterior internal fixation.Methods: The lumbosacral anterior great vessels were measured with a soft ruler.Results: The vertical distance between the bifurcation of lumbosacral anterior great vessels and the inferior border of lumbar 5 was(2.61±1.11) cm.The vertical distance between the bifurcation of the lumbosacral anterior great vessel and the vertebral midline was(1.03±0.40) cm(P>0.05).The distance between the midpoint of superior border of lumbar 5 and the inboard edge of the left and right lumbosacral anterior blood vessel was(0.34±0.31) cm and(2.15±0.40) cm,respectively;the distance between the midpoint of inferior border of lumbar 5 and the inboard edge of the left and the right lumbosacral anterior blood vessel was(1.41±0.54) cm and(2.50±0.79) cm,respectively(P<0.01).Conclusions: The bifurcation of the lumbosacral anterior great vessels lies in the right side of the vertebral midline.The distance between the vertebral midline and the inboard edge of the right lumbosacral anterior great vessel is longer than that between the vertebral midline and the inboard edge of the left lumbosacral anterior blood vessel.
Objective: To acquire some relevant parameters of the lumbosacral anterior great vessels so as to provide theoretical basis for lumbosacral anterior internal fixation.Methods: The lumbosacral anterior great vessels were measured with a soft ruler.Results: The vertical distance between the bifurcation of lumbosacral anterior great vessels and the inferior border of lumbar 5 was(2.61±1.11) cm.The vertical distance between the bifurcation of the lumbosacral anterior great vessel and the vertebral midline was(1.03±0.40) cm(P>0.05).The distance between the midpoint of superior border of lumbar 5 and the inboard edge of the left and right lumbosacral anterior blood vessel was(0.34±0.31) cm and(2.15±0.40) cm,respectively;the distance between the midpoint of inferior border of lumbar 5 and the inboard edge of the left and the right lumbosacral anterior blood vessel was(1.41±0.54) cm and(2.50±0.79) cm,respectively(P<0.01).Conclusions: The bifurcation of the lumbosacral anterior great vessels lies in the right side of the vertebral midline.The distance between the vertebral midline and the inboard edge of the right lumbosacral anterior great vessel is longer than that between the vertebral midline and the inboard edge of the left lumbosacral anterior blood vessel.
2009, 34(6): 473-476.
Abstract:
Objective: To investigate the expression of adrenomedullin(ADM) in human lung cancer and to evaluate its clinical significance.Methods: Immunohistochemical staining was performed to examine the expression of ADM in lung cancer,radioimmunoassay was applied to determine the concentration of ADM in the plasm of patients and controls,and the relationship was retrospectively analyzed between the expression of ADM in lung cancer and the clinicobiological features.Results: The expression of ADM in lung cancer was significantly higher than those in adjacent tissues and normal tissues(P<0.01),and the positive rate of ADM protein in adjacent tissues and that in the normal ones was no significant difference(P>0.05).There was a significant relationship between the expression of ADM and the grade of lung cancer(P<0.05 and P<0.01),and there were no relationships between the expression of ADM and age,histological type and TNM stage(P>0.05).The expression of ADM in the plasm of lung cancer group was significantly higher than those in the plasm of non-lung cancer group and healthy control group(P<0.05).There was a significant relationship between the expression of ADM in the plasm and TNM stage(P<0.05),and there was no relationships between the expression of ADM in the plasm and histological type(P>0.05).Conclusions: The expression of ADM significantly increased in lung cancer and was associated with grade.ADM may play an important role in the lung cancer.
Objective: To investigate the expression of adrenomedullin(ADM) in human lung cancer and to evaluate its clinical significance.Methods: Immunohistochemical staining was performed to examine the expression of ADM in lung cancer,radioimmunoassay was applied to determine the concentration of ADM in the plasm of patients and controls,and the relationship was retrospectively analyzed between the expression of ADM in lung cancer and the clinicobiological features.Results: The expression of ADM in lung cancer was significantly higher than those in adjacent tissues and normal tissues(P<0.01),and the positive rate of ADM protein in adjacent tissues and that in the normal ones was no significant difference(P>0.05).There was a significant relationship between the expression of ADM and the grade of lung cancer(P<0.05 and P<0.01),and there were no relationships between the expression of ADM and age,histological type and TNM stage(P>0.05).The expression of ADM in the plasm of lung cancer group was significantly higher than those in the plasm of non-lung cancer group and healthy control group(P<0.05).There was a significant relationship between the expression of ADM in the plasm and TNM stage(P<0.05),and there was no relationships between the expression of ADM in the plasm and histological type(P>0.05).Conclusions: The expression of ADM significantly increased in lung cancer and was associated with grade.ADM may play an important role in the lung cancer.
2009, 34(6): 476-477.
Abstract:
Objective: To observe the feasibility and clinical significance of sentinel lymph node biopsy(SLNB) in patients with breast cancer.Methods: Twenty three cases of breast cancer were given 4 ml of 1% methylene blue solution;and 15 minutes later,SLNB was carried out and inspected separately.Results: SLN was detected in 22 of the 23 cases(95.7%),with a sensitivity rate of 6/7 and false negative rate of 4.76%(1/21).Conclusions: SLNB is a simple and safe technic,which helps to reveal the state of the axillary lymph nodes.
Objective: To observe the feasibility and clinical significance of sentinel lymph node biopsy(SLNB) in patients with breast cancer.Methods: Twenty three cases of breast cancer were given 4 ml of 1% methylene blue solution;and 15 minutes later,SLNB was carried out and inspected separately.Results: SLN was detected in 22 of the 23 cases(95.7%),with a sensitivity rate of 6/7 and false negative rate of 4.76%(1/21).Conclusions: SLNB is a simple and safe technic,which helps to reveal the state of the axillary lymph nodes.
2009, 34(6): 478-480.
Abstract:
Objective: To investigate the relationship between increased peripheral blood platelets and rheumatoid arthritis(RA).Methods: One hundred and thirty-nine patients with RA were divided into normal platelet group and high platelet group according to the platelet count,and the difference between the clinical manifestation and laboratory examination was compared.At the same time,correlated analysis was carried out between the platelet count and the laboratory examination.Results: There was significant difference in swollen joint count,tender joint count,average erythrocyte sedimentation rate(ESR),C-reactive protein(CRP) and rheumatoid factor(RF) titer between the two groups(P<0.01).The platelet count of RA patients was positively correlated with ESR,CRP and RF titer(r=0.41,0.24,0.17,respectively,P<0.05 to P<0.01).The average level of anti-cyclic citrullinated peptide(CCP) antibody in the RA patients with platelet count over 450×109/L was(199±96) u/ml,while the average level of anti-CCP in the other RA patients was(118±108) u/ml.The former was significantly higher(P<0.01);X-ray Ⅱ joints lesion was observed in more than 46.2% of the patients with platelet count over 450×109/L RA,while it was 19.6% in the other group.The difference was not significant(P>0.05).Conclusions: Increased peripheral blood platelet count has some correlation with the activity of RA disease.Platelet count can be used as a simple and effective index to evaluate the activity of RA disease.
Objective: To investigate the relationship between increased peripheral blood platelets and rheumatoid arthritis(RA).Methods: One hundred and thirty-nine patients with RA were divided into normal platelet group and high platelet group according to the platelet count,and the difference between the clinical manifestation and laboratory examination was compared.At the same time,correlated analysis was carried out between the platelet count and the laboratory examination.Results: There was significant difference in swollen joint count,tender joint count,average erythrocyte sedimentation rate(ESR),C-reactive protein(CRP) and rheumatoid factor(RF) titer between the two groups(P<0.01).The platelet count of RA patients was positively correlated with ESR,CRP and RF titer(r=0.41,0.24,0.17,respectively,P<0.05 to P<0.01).The average level of anti-cyclic citrullinated peptide(CCP) antibody in the RA patients with platelet count over 450×109/L was(199±96) u/ml,while the average level of anti-CCP in the other RA patients was(118±108) u/ml.The former was significantly higher(P<0.01);X-ray Ⅱ joints lesion was observed in more than 46.2% of the patients with platelet count over 450×109/L RA,while it was 19.6% in the other group.The difference was not significant(P>0.05).Conclusions: Increased peripheral blood platelet count has some correlation with the activity of RA disease.Platelet count can be used as a simple and effective index to evaluate the activity of RA disease.
2009, 34(6): 480-481.
Abstract:
Objective: To observe the effect of ropivacaine combined with tramadol in postoperative extradural analgesia(PCEA).Methods: Fifty patients having undergone operation under extradural anesthesia received extradural cut-over analgesic pump after the operation.The formula of analgesic pump was 0.894% ropivacaine mesylate,0.8 g tramadol and 3-5 mg droperidol,which were diluted to 100 ml with normal saline.The pain score,vital signs and complication were observed at 9,12,24 and 36 hour individually.Results: No pain occurred in forty-nine patients;one patient felt satisfied.Thirty patients had phenomena of hypersomnia.No nausea,vomiting,cutaneous pruritus or respiratory repression was observed.Vital signs were steady.Conclusions: The combined therapy of ropivacaine and tramadol is effective and safe for postoperative analgesia,and has little side effect.
Objective: To observe the effect of ropivacaine combined with tramadol in postoperative extradural analgesia(PCEA).Methods: Fifty patients having undergone operation under extradural anesthesia received extradural cut-over analgesic pump after the operation.The formula of analgesic pump was 0.894% ropivacaine mesylate,0.8 g tramadol and 3-5 mg droperidol,which were diluted to 100 ml with normal saline.The pain score,vital signs and complication were observed at 9,12,24 and 36 hour individually.Results: No pain occurred in forty-nine patients;one patient felt satisfied.Thirty patients had phenomena of hypersomnia.No nausea,vomiting,cutaneous pruritus or respiratory repression was observed.Vital signs were steady.Conclusions: The combined therapy of ropivacaine and tramadol is effective and safe for postoperative analgesia,and has little side effect.
2009, 34(6): 482-484.
Abstract:
Objective: To investigate the therapeutic effect of penehyclidine hydrochloride on acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods: Forty-five patients with COPD were randomly divided into control group and treatment group.The basic regimens for the two groups were oxygen,antibiotics and aminophylline.The treatment group was given misting inhalation of sodium chloride(4 ml) and penehyclidine hydrochloride(0.5 ml) twice a day in addition to the routine therapy.The pulmonary function and the arterial blood gas were detected 7 days before and after the therapy.Results: There were no significant differences in pulmonary function or arterial gas blood before treatment between the two groups(P>0.05).After the therapy,the pulmonary function and the relevant parameters of arterial blood gas improved significantly in the two groups(P<0.01).The FEV1,FEV1/FVC,PaO2 and PaCO2 were much higher in the treatment group than in the control group(P<0.01).Conclusions: Inhalation of penehyclidine hydrochloride may efficiently improve the pulmonary function and the arterial blood gas level in patients with acute exacerhations of COPD.
Objective: To investigate the therapeutic effect of penehyclidine hydrochloride on acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods: Forty-five patients with COPD were randomly divided into control group and treatment group.The basic regimens for the two groups were oxygen,antibiotics and aminophylline.The treatment group was given misting inhalation of sodium chloride(4 ml) and penehyclidine hydrochloride(0.5 ml) twice a day in addition to the routine therapy.The pulmonary function and the arterial blood gas were detected 7 days before and after the therapy.Results: There were no significant differences in pulmonary function or arterial gas blood before treatment between the two groups(P>0.05).After the therapy,the pulmonary function and the relevant parameters of arterial blood gas improved significantly in the two groups(P<0.01).The FEV1,FEV1/FVC,PaO2 and PaCO2 were much higher in the treatment group than in the control group(P<0.01).Conclusions: Inhalation of penehyclidine hydrochloride may efficiently improve the pulmonary function and the arterial blood gas level in patients with acute exacerhations of COPD.
2009, 34(6): 484-485.
Abstract:
Objective: To investigate the effect of dipolar artificial femoral head replacement in treatment of unstable intertrochanteric hip fractures in elderly patients.Methods: Thirty-eight patients(age range 71-89) with unstable intertrochanteric hip fractures were treated by dipolar artificial femoral head replacement.Thirty-two of them had more than one complication.Results: No death or incision infection occurred in the operation.All the patients began to walk one week after the operation.No dislocation of hip was observed;3 cases developed deep vein thrombosis and the legs were not equilong in 3 cases.The results were excellent in 20 cases and good in 15 cases according to Harries standard one year after the operation.Two patients died of other diseases.Conclusions: The dipolar artificial femoral head replacement is an effective and reliable technique for treatment of intertrochanteric hip fractures in aged patients and has few complications.
Objective: To investigate the effect of dipolar artificial femoral head replacement in treatment of unstable intertrochanteric hip fractures in elderly patients.Methods: Thirty-eight patients(age range 71-89) with unstable intertrochanteric hip fractures were treated by dipolar artificial femoral head replacement.Thirty-two of them had more than one complication.Results: No death or incision infection occurred in the operation.All the patients began to walk one week after the operation.No dislocation of hip was observed;3 cases developed deep vein thrombosis and the legs were not equilong in 3 cases.The results were excellent in 20 cases and good in 15 cases according to Harries standard one year after the operation.Two patients died of other diseases.Conclusions: The dipolar artificial femoral head replacement is an effective and reliable technique for treatment of intertrochanteric hip fractures in aged patients and has few complications.
2009, 34(6): 486-488.
Abstract:
Objective: To observe the role of bilviscoelastic materials(dispersive and cohesive) in protection of corneal endothelium in cataract endocapsular phacoemulcification.Methods: Two types of cataracts were divided into 4 groups.The first type was hard nuclear cataract(≥ Ⅳ grade):24 eyes of 22 cases using dispersive and cohesive viscoelastic materials in ndocapsular phacoemulcification served as study group and 20 eyes of 20 cases using only cohesive viscoelastic materials acted as control.The second type was soft nuclear cataract(≤ Ⅲ grade):28 eyes of 25 cases using dispersive and cohesive viscoelastic materials in endocapsular phacoemulcification served as study group and 28 eyes of 24 cases using only ohesive viscoelastic materials acted as control.The corneal edema was observed one day after operation and the endothelial cell density was measured before operation and one month after operation.Results: There was statistically significant differences in corneal edema between the two groups in the first type(P<0.01);the difference was not statically different in the loss of corneal endothelium(P>0.05);there was no statistically significant differences between the two groups in the second type(P>0.05).Conclusions: Use of bilviscoelastic materials in hard nuclear cataract phacoemulcification could protect corneal endothelium and decrease coneal complications.
Objective: To observe the role of bilviscoelastic materials(dispersive and cohesive) in protection of corneal endothelium in cataract endocapsular phacoemulcification.Methods: Two types of cataracts were divided into 4 groups.The first type was hard nuclear cataract(≥ Ⅳ grade):24 eyes of 22 cases using dispersive and cohesive viscoelastic materials in ndocapsular phacoemulcification served as study group and 20 eyes of 20 cases using only cohesive viscoelastic materials acted as control.The second type was soft nuclear cataract(≤ Ⅲ grade):28 eyes of 25 cases using dispersive and cohesive viscoelastic materials in endocapsular phacoemulcification served as study group and 28 eyes of 24 cases using only ohesive viscoelastic materials acted as control.The corneal edema was observed one day after operation and the endothelial cell density was measured before operation and one month after operation.Results: There was statistically significant differences in corneal edema between the two groups in the first type(P<0.01);the difference was not statically different in the loss of corneal endothelium(P>0.05);there was no statistically significant differences between the two groups in the second type(P>0.05).Conclusions: Use of bilviscoelastic materials in hard nuclear cataract phacoemulcification could protect corneal endothelium and decrease coneal complications.
2009, 34(6): 488-490.
Abstract:
Objective: To analyze the influence of oligohydramnios at the late pregnancy on the perinatal infants and the related factors.Methods: A total of 121 cases of oligohydramnios were analyzed and compared with those with normal amniotic fluid.Results: Thirteen point fifty-one percent oligohydramnios occurred in cases exceeding 42 gestational weeks,4.28%in cases with 40+1-41+6 gestational weeks,2.86% in cases with 37-40 gestational weeks and 2.21% in cases under 37 gestational weeks.The occurrence of oligohydramnios was 24.79% in cases with high risk pregnancy.The rate of cesarean section,fetus predicament and Ⅱ-Ⅲ grade amniotic fluid affection in the oligohydramnios group was higher than that in the control group(P<0.01).The volume of oligohydramnios was negatively related to the rate of cesarean section and fetus predicament(P<0.01).The rate of rebirth stifling in the oligohydramnios group was higher than that of the control group,but the difference was not obvious(P>0.05).Conclusions: Oligohydramnios is closely associated with prolonged pregnancy and other related complications,which gravely threatens the life of perinatal infants.Therefore,timely termination of pregnancy or caesarean section is suggested to cases with oligohyrdramnios.
Objective: To analyze the influence of oligohydramnios at the late pregnancy on the perinatal infants and the related factors.Methods: A total of 121 cases of oligohydramnios were analyzed and compared with those with normal amniotic fluid.Results: Thirteen point fifty-one percent oligohydramnios occurred in cases exceeding 42 gestational weeks,4.28%in cases with 40+1-41+6 gestational weeks,2.86% in cases with 37-40 gestational weeks and 2.21% in cases under 37 gestational weeks.The occurrence of oligohydramnios was 24.79% in cases with high risk pregnancy.The rate of cesarean section,fetus predicament and Ⅱ-Ⅲ grade amniotic fluid affection in the oligohydramnios group was higher than that in the control group(P<0.01).The volume of oligohydramnios was negatively related to the rate of cesarean section and fetus predicament(P<0.01).The rate of rebirth stifling in the oligohydramnios group was higher than that of the control group,but the difference was not obvious(P>0.05).Conclusions: Oligohydramnios is closely associated with prolonged pregnancy and other related complications,which gravely threatens the life of perinatal infants.Therefore,timely termination of pregnancy or caesarean section is suggested to cases with oligohyrdramnios.
2009, 34(6): 491-492.
Abstract:
Objective: To summarize the experience in treatment of total anomalous pulmonary venous drainage(TAPVD).Methods: Eighteen cases received surgical correction of TAPVD under hypothermia and cardiopulmonary bypass.Eight supracardiac patients were operated on through the top approach of left atrium.Results: Fiteen patients survived.Early mortality occurred in 3 cases(16.7%),delayed wound closure after surgery in 2 cases and arrhythmia in 4 cases.All of them recovered uneventfully.The cardiac function returned to normal in all the 15 cases during the follow-up term of 4 to 48 months.Conclusions: The key to successful operation lies on enough anastomotic orifice and avoidance of anastomotic stenosis.
Objective: To summarize the experience in treatment of total anomalous pulmonary venous drainage(TAPVD).Methods: Eighteen cases received surgical correction of TAPVD under hypothermia and cardiopulmonary bypass.Eight supracardiac patients were operated on through the top approach of left atrium.Results: Fiteen patients survived.Early mortality occurred in 3 cases(16.7%),delayed wound closure after surgery in 2 cases and arrhythmia in 4 cases.All of them recovered uneventfully.The cardiac function returned to normal in all the 15 cases during the follow-up term of 4 to 48 months.Conclusions: The key to successful operation lies on enough anastomotic orifice and avoidance of anastomotic stenosis.
2009, 34(6): 493-494.
Abstract:
Objective: To investigate the pathogenesis,diagnosis,treatment and prognosis of diffuse axonal injury(DAI).Methods: The clinical data of 34 cases of DAI were analyzed retrospectively.Results: Among the 34 cases of DAI,21 were due to traffic accidents,10 to crashing and 3 were caused by other accidents.According to Glasgowcoma score(GCS),the recovery was good in 16 cases,moderate disability was observed in 10 cases,severe disability in 3 cases,vegetative state in 3 cases,and mortality in 2 cases.Conclusions: The mechanism of DAI is quite complicated.Traffic accidents and crashing are the major causes.Conscious disturbance is the typical clinical manifestation.MRI is superior to CT in diagnosis of DAI.Comprehensive interventions should be applied in the treatment of DAI.The outcome is closely associated with GCS and coma time.
Objective: To investigate the pathogenesis,diagnosis,treatment and prognosis of diffuse axonal injury(DAI).Methods: The clinical data of 34 cases of DAI were analyzed retrospectively.Results: Among the 34 cases of DAI,21 were due to traffic accidents,10 to crashing and 3 were caused by other accidents.According to Glasgowcoma score(GCS),the recovery was good in 16 cases,moderate disability was observed in 10 cases,severe disability in 3 cases,vegetative state in 3 cases,and mortality in 2 cases.Conclusions: The mechanism of DAI is quite complicated.Traffic accidents and crashing are the major causes.Conscious disturbance is the typical clinical manifestation.MRI is superior to CT in diagnosis of DAI.Comprehensive interventions should be applied in the treatment of DAI.The outcome is closely associated with GCS and coma time.
2009, 34(6): 495-496.
Abstract:
Objective: To compare the effect of medical abortion and vacuum suction abortion in terminating early pregnancy,and to study the acceptability and psychological status of the patients.Methods: One hundred and sixty patients intending to terminate pregnancy were divided into medical abortion group and vacuum suction abortion group.The results were compared and analyzed.Results: The complete abortion rate of vacuum suction abortion group(98.75%) was significantly higher than that of medical abortion group(87.50%),and the bleeding time was shorter than that of medical abortion group.The difference was statistically significant(P<0.01).The degree of tension and suffering in the medical abortion group was significantly lighter than that in the vacuum suction abortion group,and the acceptability degree was higher than that of abortion group.The difference was significant(P<0.01).The satisfaction degree of the two groups had no significant difference(P>0.05).Conclusions: Medical abortion and vacuum suction abortion have their own advantages and disadvantages in terminating early pregnancy.The advantages of medical abortion were lighter pain,no tension,higher acceptability degree and satisfaction,the disadvantages were longer vaginal bleeding and longer hospital stay for observation.The advantages of vacuum suction abortion were higher successful rate of abortion and shorter vaginal bleeding,the disadvantages were severe abdominal pain and tension.They are not replaceble.
Objective: To compare the effect of medical abortion and vacuum suction abortion in terminating early pregnancy,and to study the acceptability and psychological status of the patients.Methods: One hundred and sixty patients intending to terminate pregnancy were divided into medical abortion group and vacuum suction abortion group.The results were compared and analyzed.Results: The complete abortion rate of vacuum suction abortion group(98.75%) was significantly higher than that of medical abortion group(87.50%),and the bleeding time was shorter than that of medical abortion group.The difference was statistically significant(P<0.01).The degree of tension and suffering in the medical abortion group was significantly lighter than that in the vacuum suction abortion group,and the acceptability degree was higher than that of abortion group.The difference was significant(P<0.01).The satisfaction degree of the two groups had no significant difference(P>0.05).Conclusions: Medical abortion and vacuum suction abortion have their own advantages and disadvantages in terminating early pregnancy.The advantages of medical abortion were lighter pain,no tension,higher acceptability degree and satisfaction,the disadvantages were longer vaginal bleeding and longer hospital stay for observation.The advantages of vacuum suction abortion were higher successful rate of abortion and shorter vaginal bleeding,the disadvantages were severe abdominal pain and tension.They are not replaceble.
2009, 34(6): 497-499.
Abstract:
Objective: To explore the effect of urethral canal lengthening in rectification of female pseudoherma phroditism.Methods: Eight cases of female pseudoherma phroditism received traditional clitorisplasty,pudendum plasty of the greater and lesser lips,or vagina inferior segment plasty in accordance to the abnormities.As the cases were featured by shorter urethral canal,local mucous membrane tissues were used for the repair and lengthening of the urethral canal.Results: The operation was successful in all the 8 cases.The urethral canal was extended from the original length of 1.5-2.5 cm to 3.5-5.5 cm,and the external orifice of urethra was restored to normal position.Conclusions: On the basis of traditional procedures for female pseudoherma-phroditism diorthosis,urethral canal extension with autologous tissues can not only restore the anatomic and physiologic function of the cunnus,but reduce the patients' discomfort in sexual life as well as the probability of repeated urinary tract infection and other complications.
Objective: To explore the effect of urethral canal lengthening in rectification of female pseudoherma phroditism.Methods: Eight cases of female pseudoherma phroditism received traditional clitorisplasty,pudendum plasty of the greater and lesser lips,or vagina inferior segment plasty in accordance to the abnormities.As the cases were featured by shorter urethral canal,local mucous membrane tissues were used for the repair and lengthening of the urethral canal.Results: The operation was successful in all the 8 cases.The urethral canal was extended from the original length of 1.5-2.5 cm to 3.5-5.5 cm,and the external orifice of urethra was restored to normal position.Conclusions: On the basis of traditional procedures for female pseudoherma-phroditism diorthosis,urethral canal extension with autologous tissues can not only restore the anatomic and physiologic function of the cunnus,but reduce the patients' discomfort in sexual life as well as the probability of repeated urinary tract infection and other complications.
2009, 34(6): 499-500.
Abstract:
Objective: To explore the diagnosis and treatment of torsion of testicular appendage so as to improve the level of treatment.Methods: The clinical data,including the onset,treatment and prognosis of 16 cases of torsion of testicular appendage were reviewed.The age of the patients ranged from 13-42 years.Results: Eleven cases had left side torsion of testicular appendage and 5 cases the right side.The elapse of time from onset to definite diagnosis was 2 h-8 d.The diagnosis of torsion of testicular appendage in 15 cases was based on color Doppler flow imaging(CDFI) and 1 case was verified by operation.All the 16 cases underwent acute operation.Twelve cases of testicles were removed for necrosis,and only 4 cases of testicles were salvaged by operative detorsion.Conclusions: Early diagnosis of torsion of testicular appendage is very important,and CDFI is reliable for diagnosis of torsion of testicular appendage.Immediately operation after admission is essential for salvage of the testicle.
Objective: To explore the diagnosis and treatment of torsion of testicular appendage so as to improve the level of treatment.Methods: The clinical data,including the onset,treatment and prognosis of 16 cases of torsion of testicular appendage were reviewed.The age of the patients ranged from 13-42 years.Results: Eleven cases had left side torsion of testicular appendage and 5 cases the right side.The elapse of time from onset to definite diagnosis was 2 h-8 d.The diagnosis of torsion of testicular appendage in 15 cases was based on color Doppler flow imaging(CDFI) and 1 case was verified by operation.All the 16 cases underwent acute operation.Twelve cases of testicles were removed for necrosis,and only 4 cases of testicles were salvaged by operative detorsion.Conclusions: Early diagnosis of torsion of testicular appendage is very important,and CDFI is reliable for diagnosis of torsion of testicular appendage.Immediately operation after admission is essential for salvage of the testicle.
2009, 34(6): 501-503.
Abstract:
Objective: To observe the mechanism of inflammation during acute coronaria syndrome(ACS) and the anti-inflammation role of fluvastatin.Methods: Seventy-two cases of stable angina pectoris(SAP) were selected as control,and 84 cases of ACS were enrolled in the treatment group which included 39 cases of unstable angina pectoris(UAP),25 cases of non-ST elevated myocardial infarction(NSTEMI) and 20 cases of ST elevated myocardial infarction(STEMI).The treatment group was prescribed fluvastatin 40 mg in addition to the routine therapy.The fluvastatin was taken after supper and the treatment course lasted for 4 weeks.The concentrations of high sensitive C reactive protein(hs-CRP),cholesterol(CHO) and low density lipoprotein(LDL-C) in the blood of the patients were determined before and after treatment separately.Results: Before treatment,the concentration of hs-CRP in ACS group was obviously higher than that in SAP group(P<0.01),while the hs-CRP in STEMI group had no statistic significance compared with that in NSTEMI or UAP groups(P>0.05);the concentrations of CHO and LDL-C in ACS group were not significantly different compared with that in SAP group(P>0.05).After treatment,the concentrations of hs-CRP,CHO and LDL-C in ACS groups were lowered obviously(P<0.01).Conclusions: Inflammation plays an important role in the process of ACS,and fluvastatin possesses the ability of moderating cholesterol and anti-inflammation.
Objective: To observe the mechanism of inflammation during acute coronaria syndrome(ACS) and the anti-inflammation role of fluvastatin.Methods: Seventy-two cases of stable angina pectoris(SAP) were selected as control,and 84 cases of ACS were enrolled in the treatment group which included 39 cases of unstable angina pectoris(UAP),25 cases of non-ST elevated myocardial infarction(NSTEMI) and 20 cases of ST elevated myocardial infarction(STEMI).The treatment group was prescribed fluvastatin 40 mg in addition to the routine therapy.The fluvastatin was taken after supper and the treatment course lasted for 4 weeks.The concentrations of high sensitive C reactive protein(hs-CRP),cholesterol(CHO) and low density lipoprotein(LDL-C) in the blood of the patients were determined before and after treatment separately.Results: Before treatment,the concentration of hs-CRP in ACS group was obviously higher than that in SAP group(P<0.01),while the hs-CRP in STEMI group had no statistic significance compared with that in NSTEMI or UAP groups(P>0.05);the concentrations of CHO and LDL-C in ACS group were not significantly different compared with that in SAP group(P>0.05).After treatment,the concentrations of hs-CRP,CHO and LDL-C in ACS groups were lowered obviously(P<0.01).Conclusions: Inflammation plays an important role in the process of ACS,and fluvastatin possesses the ability of moderating cholesterol and anti-inflammation.
2009, 34(6): 505-507.
Abstract:
Objective: To investigate the clinical value of emssion computed tomography(ECT) bone imaging combined with serum prostate specific antigen(PSA) in diagnosing bone metastasis of prostate carcinoma.Methods: Fifty-six cases of prostate carcinoma were reviewed and the correlation between ECT,PSA and bone metastasis was analyzed.Results: The incidence of bone metastasis of prostate carcinoma was 67.8%.The value of PSA between bone metastasis(BM) group and non-BM(NBM) group had significant difference(P<0.01);the value of PSA and the degree of bone metastasis were positively correlated(P<0.01).Conclusions: ECT is highly sensitive to bone metastasis of prostate carcinoma.If PSA is <10 μg/L,the chance of BM is quite small;if PSA is >100 μg/L,LBM is in high suspect.It suggests that if PSA is > 20 μg/L,LECT bone imaging should be performed.
Objective: To investigate the clinical value of emssion computed tomography(ECT) bone imaging combined with serum prostate specific antigen(PSA) in diagnosing bone metastasis of prostate carcinoma.Methods: Fifty-six cases of prostate carcinoma were reviewed and the correlation between ECT,PSA and bone metastasis was analyzed.Results: The incidence of bone metastasis of prostate carcinoma was 67.8%.The value of PSA between bone metastasis(BM) group and non-BM(NBM) group had significant difference(P<0.01);the value of PSA and the degree of bone metastasis were positively correlated(P<0.01).Conclusions: ECT is highly sensitive to bone metastasis of prostate carcinoma.If PSA is <10 μg/L,the chance of BM is quite small;if PSA is >100 μg/L,LBM is in high suspect.It suggests that if PSA is > 20 μg/L,LECT bone imaging should be performed.
2009, 34(6): 510-512.
Abstract:
Objective: To investigate the causes of vaginal bleeding after menopause in the elderly.Methods: The clinical data of 113 elderly women with vaginal bleeding were analyzed retrospectively.Results: Among the 113 cases,78 cases were benign lesions,of which 52 were cervicitis,10 endometritis,7 uterine leiomyoma,7 endometrial hyperplasia and 2 ovarian cysts;32 cases were malignant tumors,of which 19 were cervical cancer,10 endometrial cancer,2 ovarian cancer cases and 1 case was fallopian tube cancer;3 cases were precancerous lesions.Sixty-two cases of vaginal bleeding were caused by inflammation.The incidence of malignant tumors was 44.00% in the group over 70 years of age,while it was only 23.86% in the group under 70.The difference was significant between the two groups(P<0.05).Conclusions: The main cause of vaginal bleeding in the elderly after menopause is gynecological inflammation,and the next is cancer.Knowledge of the causes is beneficial to early diagnosis and treatment.
Objective: To investigate the causes of vaginal bleeding after menopause in the elderly.Methods: The clinical data of 113 elderly women with vaginal bleeding were analyzed retrospectively.Results: Among the 113 cases,78 cases were benign lesions,of which 52 were cervicitis,10 endometritis,7 uterine leiomyoma,7 endometrial hyperplasia and 2 ovarian cysts;32 cases were malignant tumors,of which 19 were cervical cancer,10 endometrial cancer,2 ovarian cancer cases and 1 case was fallopian tube cancer;3 cases were precancerous lesions.Sixty-two cases of vaginal bleeding were caused by inflammation.The incidence of malignant tumors was 44.00% in the group over 70 years of age,while it was only 23.86% in the group under 70.The difference was significant between the two groups(P<0.05).Conclusions: The main cause of vaginal bleeding in the elderly after menopause is gynecological inflammation,and the next is cancer.Knowledge of the causes is beneficial to early diagnosis and treatment.
2009, 34(6): 512-514.
Abstract:
Objective: To observe C-reactive protein(CRP) level variation in patients with chronic obstructive pulmonary disease(COPD) and to investigate its clinical significance.Methods: The serum CRP level of 64 patients with COPD at acute exacerbation(AECOPD) and 62 patients at stable stage was measured,and the white blood cells(WBC) and percentage of neutrophils(NE%) were also collected.Results: The serum CRP level of AECOPD patients(53.8±15.3) mg/L was significantly higher than that of the patients at the stable stage(6.4±5.8) mg/L(P<0.01);the positive rate of the serum CRP of AECOPD patients was significantly higher(96.88%) than that of WBC(P<0.01) and NE%(P<0.05).Conclusions: The serum CRP level of COPD patients increases significantly at the acute exacerbation stage and it is a preferential index in diagnosis of AECOPD.
Objective: To observe C-reactive protein(CRP) level variation in patients with chronic obstructive pulmonary disease(COPD) and to investigate its clinical significance.Methods: The serum CRP level of 64 patients with COPD at acute exacerbation(AECOPD) and 62 patients at stable stage was measured,and the white blood cells(WBC) and percentage of neutrophils(NE%) were also collected.Results: The serum CRP level of AECOPD patients(53.8±15.3) mg/L was significantly higher than that of the patients at the stable stage(6.4±5.8) mg/L(P<0.01);the positive rate of the serum CRP of AECOPD patients was significantly higher(96.88%) than that of WBC(P<0.01) and NE%(P<0.05).Conclusions: The serum CRP level of COPD patients increases significantly at the acute exacerbation stage and it is a preferential index in diagnosis of AECOPD.
2009, 34(6): 523-525.
Abstract:
Objective: To study the value of full-field digital mammography(FFDM) in diagnosing early breast carcinoma.Methods: Fifty-eight cases of breast cancer confirmed by surgery and pathology were collected in the study.All the cases had been examined by FFDM before surgery.Craniocaudal view and midiolateral oblique view were conducted,and midiolateral view or spot view was employed when necessary.Results: Lumps were detected in 38 cases,malignant calcification was noticed in 26 cases,focal architecture distortion in 8 cases,small focus of increased density in 4 cases,"ductal sign" in 5 cases and distended blood vessel in 15 cases.The diagnosis rate was 87.9% by FFDM.Conclusions: FFDM can clearly demonstrate each layer of the breast,as well as the direct and indirect signs of breast carcinoma,which is of great value in diagnosis of early breast carcinoma.
Objective: To study the value of full-field digital mammography(FFDM) in diagnosing early breast carcinoma.Methods: Fifty-eight cases of breast cancer confirmed by surgery and pathology were collected in the study.All the cases had been examined by FFDM before surgery.Craniocaudal view and midiolateral oblique view were conducted,and midiolateral view or spot view was employed when necessary.Results: Lumps were detected in 38 cases,malignant calcification was noticed in 26 cases,focal architecture distortion in 8 cases,small focus of increased density in 4 cases,"ductal sign" in 5 cases and distended blood vessel in 15 cases.The diagnosis rate was 87.9% by FFDM.Conclusions: FFDM can clearly demonstrate each layer of the breast,as well as the direct and indirect signs of breast carcinoma,which is of great value in diagnosis of early breast carcinoma.
2009, 34(6): 526-528.
Abstract:
Objective: To evaluate the role of CT perfusion imaging(CTP) in preoperative grading of astrocytoma.Methods: CTP was performed in 31 patients with astrocytioma.Forteen cases were proved to be low-grade astrocytoma and 17 cases high-grade astrocytoma.All the cases received CT and CTP examinations.The cerebral blood flow(CBF),cerebral blood volume(CBV) and permeability surface(PS) values were calculated,and the perfusion maps were statistically analyzed.Results: The CBF,CBV and PS value of the astrocytoma were higher than that of the normal brain tissue(P<0.01).The CBF,CBV and PS value of high grade astrocytoma were higher than that of low grade astrocytoma(P<0.01).There was a positive correlation among the CBF,CBV and PS value in the astrocytoma(P<0.01).Conclusions: CTP has great clinical value in preoperative grading of astrocytoma.
Objective: To evaluate the role of CT perfusion imaging(CTP) in preoperative grading of astrocytoma.Methods: CTP was performed in 31 patients with astrocytioma.Forteen cases were proved to be low-grade astrocytoma and 17 cases high-grade astrocytoma.All the cases received CT and CTP examinations.The cerebral blood flow(CBF),cerebral blood volume(CBV) and permeability surface(PS) values were calculated,and the perfusion maps were statistically analyzed.Results: The CBF,CBV and PS value of the astrocytoma were higher than that of the normal brain tissue(P<0.01).The CBF,CBV and PS value of high grade astrocytoma were higher than that of low grade astrocytoma(P<0.01).There was a positive correlation among the CBF,CBV and PS value in the astrocytoma(P<0.01).Conclusions: CTP has great clinical value in preoperative grading of astrocytoma.
2009, 34(6): 529-531.
Abstract:
Objective: To explore the distribution,types and drug resistance of pathogenic bacteria of burn patients,and guide the rational use of antibiotics.Methods: Forty-seven blood and wound excreta samples were collected from 27 severe burn patients treated between Jan.2005 and Nov.2007.The pathogenic bacteria were cultured for detection of drug sensitivity.Results: Pathogenic bacteria were detected in 43 samples,and the detection rate was 91.2%.The total detected bacteria belonged to 10 species and 52 strains.Among them,22 strains were G+ bacteria and 30 were G- bacteria.Pseudomonas aeruginosa was ranked the first in G- bacteriums and Staphylococcus aureus was ranked the first in G+ bacteriums.Drug sensitivity test indicated that 10 species of pathogenic bacteria showed different extend drug resistance to 12 commonly used antibiotics.Staphylococcus aureus showed drug resistance to 9 antibiotics but 100% sensitivity to vancocin.Aeruginosus bacillus kept higher resistance rate to the third and fourth generation cephalosporins and meropenem.Conclusions: Pseudomonas aeruginosa and Staphylococcus aureus are the two most mainly pathogenic bacteria in the infection of burn patients.Dynamic observation of changes in pathogenic strains and sensitivty of bacteria to antibiotics are useful for clinical prevention and cure of burn infection.
Objective: To explore the distribution,types and drug resistance of pathogenic bacteria of burn patients,and guide the rational use of antibiotics.Methods: Forty-seven blood and wound excreta samples were collected from 27 severe burn patients treated between Jan.2005 and Nov.2007.The pathogenic bacteria were cultured for detection of drug sensitivity.Results: Pathogenic bacteria were detected in 43 samples,and the detection rate was 91.2%.The total detected bacteria belonged to 10 species and 52 strains.Among them,22 strains were G+ bacteria and 30 were G- bacteria.Pseudomonas aeruginosa was ranked the first in G- bacteriums and Staphylococcus aureus was ranked the first in G+ bacteriums.Drug sensitivity test indicated that 10 species of pathogenic bacteria showed different extend drug resistance to 12 commonly used antibiotics.Staphylococcus aureus showed drug resistance to 9 antibiotics but 100% sensitivity to vancocin.Aeruginosus bacillus kept higher resistance rate to the third and fourth generation cephalosporins and meropenem.Conclusions: Pseudomonas aeruginosa and Staphylococcus aureus are the two most mainly pathogenic bacteria in the infection of burn patients.Dynamic observation of changes in pathogenic strains and sensitivty of bacteria to antibiotics are useful for clinical prevention and cure of burn infection.
2009, 34(6): 531-533.
Abstract:
Objective: To study the distribution and drug susceptibility of pathogenic bacteria in the bile samples.Methods: The distribution and drug resistance of 634 strains of pathogenic bacteria isolated from the bile samples were analyzed retrospectively.Results: Among the 634 strains isolated,248 were Gram positive bacteria,369 Gram negative bacteria and 27 fungus.Two hundred and ten strains of the G+ bacteria were Enterococcus and 162 strains of G- bacteria were E.coli.G+ bacteria were the most susceptible to vancomycin,while G- bacteria were the most sensitive to amikacin.Conclusions: As the amount of pathogenic bacteria,the distribution of microbial population in the bile and their drug resistance to antibiotics are changing,proper antibiotics should be chosen in accordance to the results of germiculture.
Objective: To study the distribution and drug susceptibility of pathogenic bacteria in the bile samples.Methods: The distribution and drug resistance of 634 strains of pathogenic bacteria isolated from the bile samples were analyzed retrospectively.Results: Among the 634 strains isolated,248 were Gram positive bacteria,369 Gram negative bacteria and 27 fungus.Two hundred and ten strains of the G+ bacteria were Enterococcus and 162 strains of G- bacteria were E.coli.G+ bacteria were the most susceptible to vancomycin,while G- bacteria were the most sensitive to amikacin.Conclusions: As the amount of pathogenic bacteria,the distribution of microbial population in the bile and their drug resistance to antibiotics are changing,proper antibiotics should be chosen in accordance to the results of germiculture.
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