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2009 Vol. 34, No. 9
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2009, 34(9): 753-755.
Abstract:
Objective: To observe the biocompatibility of modified polylactic acid vector with Schwann cell.Methods: Immersed extraction of modified PLA affect to Proliferation and cytotoxicity stage of Schwann cell by MTT method,Schwann cell morphology and adhesion condition on surface of materials were observated by scanning electro microscope and Fluor spectrophotometer.Results: Cytotoxicity stage of modified polylactic acid vector were 0-1 stage,and the mumble of schwann cells and adhesion were better than unmodified PLA,but all materials were as good as culture well(P< 0.01).Conclusions: Modified polylactic acid vector have better biocompatibility with Schwann cell,and their cytotropism were improved.
Objective: To observe the biocompatibility of modified polylactic acid vector with Schwann cell.Methods: Immersed extraction of modified PLA affect to Proliferation and cytotoxicity stage of Schwann cell by MTT method,Schwann cell morphology and adhesion condition on surface of materials were observated by scanning electro microscope and Fluor spectrophotometer.Results: Cytotoxicity stage of modified polylactic acid vector were 0-1 stage,and the mumble of schwann cells and adhesion were better than unmodified PLA,but all materials were as good as culture well(P< 0.01).Conclusions: Modified polylactic acid vector have better biocompatibility with Schwann cell,and their cytotropism were improved.
2009, 34(9): 756-758.
Abstract:
Objective: To detect the proportion of peripheval blood T cell subsets(PBMCs) and the level of IFN-γ/IL-4 production of peripheral blood in patients with cysticercosis,and to investigate the role of T cell subsets in immune regulation of cysticercus cellulosae infection.Methods: The proportions of T-cell subsets of PBMCs and Th1/Th2 cytokines producing cells in patients with cysticercosis were detected by four-color flow cytometry.Cellquest or WinMDI 2.8 was used in analysis of T-cell subsets.Results: The percentage of CD3+ and CD4+ T-cells subsets,and the ratio of CD4+/CD8 in patients with cysticercosis were higher than those of the control(P<0.01).The percentage of secreting IFN-γ/IL-4 CD3+ of PBMC in patients with cysticercosis was not higher than that of the control(P>0.05).Conclusions: The patients with cysticercosis have the higher percentages of CD3+ and CD4+ cells than the control,presenting an imbalance of T cell subsets and abnormality of immunity.
Objective: To detect the proportion of peripheval blood T cell subsets(PBMCs) and the level of IFN-γ/IL-4 production of peripheral blood in patients with cysticercosis,and to investigate the role of T cell subsets in immune regulation of cysticercus cellulosae infection.Methods: The proportions of T-cell subsets of PBMCs and Th1/Th2 cytokines producing cells in patients with cysticercosis were detected by four-color flow cytometry.Cellquest or WinMDI 2.8 was used in analysis of T-cell subsets.Results: The percentage of CD3+ and CD4+ T-cells subsets,and the ratio of CD4+/CD8 in patients with cysticercosis were higher than those of the control(P<0.01).The percentage of secreting IFN-γ/IL-4 CD3+ of PBMC in patients with cysticercosis was not higher than that of the control(P>0.05).Conclusions: The patients with cysticercosis have the higher percentages of CD3+ and CD4+ cells than the control,presenting an imbalance of T cell subsets and abnormality of immunity.
2009, 34(9): 759-761.
Abstract:
Objective: To study the changes of diaphragm function of rats when in restrictive position.Methods: Twenty SD rats were randomly divided into two groups:control group and restrictive position group.The rats in restrictive position group were hung with their upper limbs bound for 12 hours.The maximal twitch torce(Pt),maximal tetanic torce(Po),contraction time(CT),half-relaxtion time(1/2 RT),and the force frequency curve at 10,20,40,60 and 100Hz were recorded.The superoxide dismulase(SOD),malondialdehyde(MDA),succinic dehydrogenase(SDH) in the diaphragm were detected.The ultrastructures of the diaphragm were examined by electron microscope.Results: The Pt and Po in the restrictive position group were lower than those in the control group(P<0.01),but the CT and 1/2RT were longer(P<0.01);When 10,20,40,60 and 100 Hz square-wave voltage was given to stimulate the diaphragm,the tension of the diaphragm in the restrictive position group was significantly lower than that of the control group(P<0.05 to P<0.01).The SOD and SDH in the restrictive position group were significantly lower than those of control group(P<0.01),and the MDA were higher(P<0.01).The electron microscopic morphometry of the diaphragm in the restrictive position group revealed that the diaphragm myoneme was confused and broken;the mitochondria was in a state of vacuolization and expanded;Myelinfigures could be seen,and the sarcoplasmic reticulum was distended.Conclusions: The diaphragm systolic function of the rats in the restrictive position group is damaged,which may be related to the decreased activity of SOD and SDH,as well as the increase of MDA content.
Objective: To study the changes of diaphragm function of rats when in restrictive position.Methods: Twenty SD rats were randomly divided into two groups:control group and restrictive position group.The rats in restrictive position group were hung with their upper limbs bound for 12 hours.The maximal twitch torce(Pt),maximal tetanic torce(Po),contraction time(CT),half-relaxtion time(1/2 RT),and the force frequency curve at 10,20,40,60 and 100Hz were recorded.The superoxide dismulase(SOD),malondialdehyde(MDA),succinic dehydrogenase(SDH) in the diaphragm were detected.The ultrastructures of the diaphragm were examined by electron microscope.Results: The Pt and Po in the restrictive position group were lower than those in the control group(P<0.01),but the CT and 1/2RT were longer(P<0.01);When 10,20,40,60 and 100 Hz square-wave voltage was given to stimulate the diaphragm,the tension of the diaphragm in the restrictive position group was significantly lower than that of the control group(P<0.05 to P<0.01).The SOD and SDH in the restrictive position group were significantly lower than those of control group(P<0.01),and the MDA were higher(P<0.01).The electron microscopic morphometry of the diaphragm in the restrictive position group revealed that the diaphragm myoneme was confused and broken;the mitochondria was in a state of vacuolization and expanded;Myelinfigures could be seen,and the sarcoplasmic reticulum was distended.Conclusions: The diaphragm systolic function of the rats in the restrictive position group is damaged,which may be related to the decreased activity of SOD and SDH,as well as the increase of MDA content.
2009, 34(9): 762-764.
Abstract:
Objective: To study the effect of Magnesium sulfate(MgSO4) pretreatment on the content of nitrics oxide(NO) and the activitiy of nitric oxide synthase(NOS) following global cerebral ischemia reperfusion(I/R) injury in mice.Methods: The mice were randomly divided into sham operation group,I/R group and pretreatment groups(pretreated with low,medium and high doses of MgSO4).Global cerebral ischemia-reperfusion injury model was made.The change of EEG was monitored and the pathological change in morphology was observed.The content of NO and the activity of NOS and inducible NOS(iNOS) were also detected.Results: The change of ischemic impairment in MgSO4 pretreatment groups was lighter than that in I/R group.The contents of NO and the activities of NOS and iNOS in the sham operation group and MgSO4 pretreatment groups were all significantly lower than those of I/R group(P<0.05-P<0.01).Conclusions: MgSO4 pretreatment may reduce the degree of neuron injury and have protective effect on cerebral ischemia-reperfusion injury.The mechanism may be associated with the decrease of the content of NO as well as the activities of NOS and iNOS.
Objective: To study the effect of Magnesium sulfate(MgSO4) pretreatment on the content of nitrics oxide(NO) and the activitiy of nitric oxide synthase(NOS) following global cerebral ischemia reperfusion(I/R) injury in mice.Methods: The mice were randomly divided into sham operation group,I/R group and pretreatment groups(pretreated with low,medium and high doses of MgSO4).Global cerebral ischemia-reperfusion injury model was made.The change of EEG was monitored and the pathological change in morphology was observed.The content of NO and the activity of NOS and inducible NOS(iNOS) were also detected.Results: The change of ischemic impairment in MgSO4 pretreatment groups was lighter than that in I/R group.The contents of NO and the activities of NOS and iNOS in the sham operation group and MgSO4 pretreatment groups were all significantly lower than those of I/R group(P<0.05-P<0.01).Conclusions: MgSO4 pretreatment may reduce the degree of neuron injury and have protective effect on cerebral ischemia-reperfusion injury.The mechanism may be associated with the decrease of the content of NO as well as the activities of NOS and iNOS.
2009, 34(9): 765-768.
Abstract:
Objective: To investigate the sensitivity of lung adenocarcinoma cells to gemcitabine(GE) after c-myc RNA interference.Methods: The c-myc-siRNA expression vector was constructed and confirmed by sequencing,and its expression vector was transfected into A549 cells.G418(geneticin) was used for selecting the cell line which expressed c-myc-siRNA stably.The level of c-myc was tested by FQ RT-PCR and western blot.The transfected cells were treated with gemcitabine,which were then divide into GE+siRNA group,GE group,siRNA group and control group,with 12 cases in each.The cell proliferation and apoptosis were assayed by tetrazolium bromide colorimetry and flow cyclometry,respectively.Results: c-myc-siRNA expression vector was constructed and transfected into A549 cells successfully.The c-myc mRNA and protein expression was effectively reduced(71.9% and 85.6% respectively).The cells treated with c-myc-siRNA and gemcitabine had a lower absorbance value at each time point than that of simple gemcitabine group,simple c-myc-siRNA group or control group(P<0.01),and the apoptosis rate was also decreased(P<0.01).Conclusions: The c-myc RNA interference can enhance the sensitivity of lung adenocarcinoma A549 cells to gemcitabine.
Objective: To investigate the sensitivity of lung adenocarcinoma cells to gemcitabine(GE) after c-myc RNA interference.Methods: The c-myc-siRNA expression vector was constructed and confirmed by sequencing,and its expression vector was transfected into A549 cells.G418(geneticin) was used for selecting the cell line which expressed c-myc-siRNA stably.The level of c-myc was tested by FQ RT-PCR and western blot.The transfected cells were treated with gemcitabine,which were then divide into GE+siRNA group,GE group,siRNA group and control group,with 12 cases in each.The cell proliferation and apoptosis were assayed by tetrazolium bromide colorimetry and flow cyclometry,respectively.Results: c-myc-siRNA expression vector was constructed and transfected into A549 cells successfully.The c-myc mRNA and protein expression was effectively reduced(71.9% and 85.6% respectively).The cells treated with c-myc-siRNA and gemcitabine had a lower absorbance value at each time point than that of simple gemcitabine group,simple c-myc-siRNA group or control group(P<0.01),and the apoptosis rate was also decreased(P<0.01).Conclusions: The c-myc RNA interference can enhance the sensitivity of lung adenocarcinoma A549 cells to gemcitabine.
2009, 34(9): 769-772.
Abstract:
Objective: To investigate the clinical effect of noninvasive positive pressure ventilation(NPPV) on patients with chronic obstructive pulmonary disease(COPD) complicated with respiratory failure,and the factors affecting the results.Methods: One hundred and forty-four patients with COPD complicated with respiratory failure were divided into conventional therapy group and NPPV therapy group.The patients' age,COPD history,heart rate at 2,24 hours before and after the therapy,respiratory rate,systolic and diastolic pressure,body temperature,blood white cell counting,blood sodium,arterial blood gas(pH、PaCO2、PaO2),oxygenation index(PaO2/FiO2) and Glasgow coma score were recorded and analyzed.Results: In the NPPV group,there was a significant improvement of PaO2 and pH at 2 hours after the therapy,while PaCO2 descended.The other indexes further improved at 24 hours after the therapy(P<0.05).In the conventional therapy group,PaCO2 and pH did not improve significantly at 2 hours after the therapy(P>0.05) but there was a significant improvement of PaO2 at 24 hours after the therapy(P<0.05),anyhow,the improvement was not as significant as the NPPV group(P<0.01).The rate of failed treatment and end tracheal intubation in the NPPV group was markedly lower than that in the conventional therapy group(P<0.05).Aged patients,patients with severe respiratory acidosis,high PaCO2 or in a coma had a higher risk of failure.Conclusions: Noninvasive positive pressure ventilation is effective for patients with COPD complicated with respiratory failure.Aged patients and patients with serious respiratory acidosis or heavy CO2 retention should resort to tracheal intubation if NPPV failed to act.
Objective: To investigate the clinical effect of noninvasive positive pressure ventilation(NPPV) on patients with chronic obstructive pulmonary disease(COPD) complicated with respiratory failure,and the factors affecting the results.Methods: One hundred and forty-four patients with COPD complicated with respiratory failure were divided into conventional therapy group and NPPV therapy group.The patients' age,COPD history,heart rate at 2,24 hours before and after the therapy,respiratory rate,systolic and diastolic pressure,body temperature,blood white cell counting,blood sodium,arterial blood gas(pH、PaCO2、PaO2),oxygenation index(PaO2/FiO2) and Glasgow coma score were recorded and analyzed.Results: In the NPPV group,there was a significant improvement of PaO2 and pH at 2 hours after the therapy,while PaCO2 descended.The other indexes further improved at 24 hours after the therapy(P<0.05).In the conventional therapy group,PaCO2 and pH did not improve significantly at 2 hours after the therapy(P>0.05) but there was a significant improvement of PaO2 at 24 hours after the therapy(P<0.05),anyhow,the improvement was not as significant as the NPPV group(P<0.01).The rate of failed treatment and end tracheal intubation in the NPPV group was markedly lower than that in the conventional therapy group(P<0.05).Aged patients,patients with severe respiratory acidosis,high PaCO2 or in a coma had a higher risk of failure.Conclusions: Noninvasive positive pressure ventilation is effective for patients with COPD complicated with respiratory failure.Aged patients and patients with serious respiratory acidosis or heavy CO2 retention should resort to tracheal intubation if NPPV failed to act.
2009, 34(9): 773-775.
Abstract:
Objective: To explore the mutual relations among blood sugar,blood sodium,C reactive protein(CRP),multiple organ dysfunction syndrom(MODS) and prognosis of illness when infants with severe pneumonia were complicated by systemic inflammatory response syndrom(SIRS).Methods: Fifty-one cases with severe pneumonia when complicated by SIRS were analyzed including organ failure and the changes of blood sugar,blood sodium,CRP and their relationship,similarly the prognosis of these infants was analyzed.Results: In 51 cases with severe pneumonia,33 cases were complicated by SIRS.Comparing the morbidity rate of MODS and the fatality rate of SIRS infants with non SIRS ones,there were no obvious differences(P>0.05).The blood sugar and CRP levels of SIRS infants were significantly higher than non SIRS group(P<0.01),but the blood sodium level was significantly lower than in non SIRS group(P<0.01).Conclusions: To apply the diagnostic standards of SIRS and the detection of blood sugar,blood sodium and CRP would help to judge the severity of infants with pneumonia,which could instruct paediatric clinical work.Enough attention should be payed to children with SIRS and dynamic examination of blood sugar,blood sodium and CRP.
Objective: To explore the mutual relations among blood sugar,blood sodium,C reactive protein(CRP),multiple organ dysfunction syndrom(MODS) and prognosis of illness when infants with severe pneumonia were complicated by systemic inflammatory response syndrom(SIRS).Methods: Fifty-one cases with severe pneumonia when complicated by SIRS were analyzed including organ failure and the changes of blood sugar,blood sodium,CRP and their relationship,similarly the prognosis of these infants was analyzed.Results: In 51 cases with severe pneumonia,33 cases were complicated by SIRS.Comparing the morbidity rate of MODS and the fatality rate of SIRS infants with non SIRS ones,there were no obvious differences(P>0.05).The blood sugar and CRP levels of SIRS infants were significantly higher than non SIRS group(P<0.01),but the blood sodium level was significantly lower than in non SIRS group(P<0.01).Conclusions: To apply the diagnostic standards of SIRS and the detection of blood sugar,blood sodium and CRP would help to judge the severity of infants with pneumonia,which could instruct paediatric clinical work.Enough attention should be payed to children with SIRS and dynamic examination of blood sugar,blood sodium and CRP.
2009, 34(9): 775-777.
Abstract:
Objective: To summary the experience in handling vascular graft infection.Methods: Eight cases of vascular graft infection were all treated by removing the grafts and debridement.Two of them were received autogenous great saphenous vein graft in the extra-anatomic bypass,and one of them was performed allotopia graft replacement.Results: Three cases had amputation above the knee after removing the grafts and one case undertook Budd-Chiari syndrome radical correction operation.The infection in other cases was controlled and the wound healed.No patients died.Conclusions: Application of variant therapeutic measures to graft infection may acquire satisfactory clinical effect.
Objective: To summary the experience in handling vascular graft infection.Methods: Eight cases of vascular graft infection were all treated by removing the grafts and debridement.Two of them were received autogenous great saphenous vein graft in the extra-anatomic bypass,and one of them was performed allotopia graft replacement.Results: Three cases had amputation above the knee after removing the grafts and one case undertook Budd-Chiari syndrome radical correction operation.The infection in other cases was controlled and the wound healed.No patients died.Conclusions: Application of variant therapeutic measures to graft infection may acquire satisfactory clinical effect.
2009, 34(9): 778-780.
Abstract:
Objective: To assess the technique and clinical effect of improved transvaginal hysterectomy(TVH) for non-prolapsed uterus.Methods: Seventy cases of non-prolapsed uterus were performed the improved transvaginal hysterectomy(a-TVH) and the other 60 cases transabdominal hysterectomy(TAH).The outcome was compared.Results: The non-prolapsed uterus with the size of 16 weeks of gestation was safely removed by a-TAH,with no damage to the adjacent organs.For the cases with the uterus size ≤ 12 weeks of gestation,the average operation time was(66.41±19.56) min and(78.40±22.28) min in the a-TVH group and TAH group,respectively(P<0.01).The average volume of blood loss was(86.20±21.21) ml and(100.51±18.34) ml in a-TVH group and TAH group,respectively(P<0.01).For the cases with the uterus size >12 weeks of gestation,there was no significant difference in the average operation time or the average volume of blood loss between the two groups(P>0.05).In the TVH group,the anus exhaust time was(28.24 ±4.23) h and the first time to move about was(27.25±2.56) h after the operation;postoperative pain was observed in 7.14% of the patients and the incidence of fever was 5.71%;the average hospital stay was(5±1.2) d after the operation.In the TAH group,the anus exhaust time was(39.25 ±3.44) h and the first time to move about was(36.13±3.52) h after the operation;85.00% of the patients complained of postoperative pain and 25% of the patients developed fever;the average hospital stay was(7±1.3) d after the operation.The difference was significant(P<0.01).Conclusions: a-TVH is a good operative method with the advantages of less damage and quicker recovery.For cases of benign disease of the uterus,non serious pelvic adherence or bulk of the uterus ≤ 16 weeks of gestation,the TVH is the first choice.
Objective: To assess the technique and clinical effect of improved transvaginal hysterectomy(TVH) for non-prolapsed uterus.Methods: Seventy cases of non-prolapsed uterus were performed the improved transvaginal hysterectomy(a-TVH) and the other 60 cases transabdominal hysterectomy(TAH).The outcome was compared.Results: The non-prolapsed uterus with the size of 16 weeks of gestation was safely removed by a-TAH,with no damage to the adjacent organs.For the cases with the uterus size ≤ 12 weeks of gestation,the average operation time was(66.41±19.56) min and(78.40±22.28) min in the a-TVH group and TAH group,respectively(P<0.01).The average volume of blood loss was(86.20±21.21) ml and(100.51±18.34) ml in a-TVH group and TAH group,respectively(P<0.01).For the cases with the uterus size >12 weeks of gestation,there was no significant difference in the average operation time or the average volume of blood loss between the two groups(P>0.05).In the TVH group,the anus exhaust time was(28.24 ±4.23) h and the first time to move about was(27.25±2.56) h after the operation;postoperative pain was observed in 7.14% of the patients and the incidence of fever was 5.71%;the average hospital stay was(5±1.2) d after the operation.In the TAH group,the anus exhaust time was(39.25 ±3.44) h and the first time to move about was(36.13±3.52) h after the operation;85.00% of the patients complained of postoperative pain and 25% of the patients developed fever;the average hospital stay was(7±1.3) d after the operation.The difference was significant(P<0.01).Conclusions: a-TVH is a good operative method with the advantages of less damage and quicker recovery.For cases of benign disease of the uterus,non serious pelvic adherence or bulk of the uterus ≤ 16 weeks of gestation,the TVH is the first choice.
2009, 34(9): 781-782.
Abstract:
Objective: To observe the curative effect of anti-depression drug in treatment of patients with unstable angina pectoris accompanied by depression.Methods: Fifty-eight patients were randomly divided into two groups.In addition to the routine therapy,the treatment group were administered paroxetine 20-60 mg a day or xitaipulan 10-40 mg a day orally.Both groups were observed for eight weeks.Results: The symptom of depression in the treatment group was improved and the angina pectoris released(P<0.05),but no obvious effect was observed in the electrocardiogram of patients with unstable angina pectoris(P>0.05).Conclusions: Anti-depression drug may effectively relieve the symptom of depression and the angina pectoris,and improve the life quality of patients with unstable angina pectoris.
Objective: To observe the curative effect of anti-depression drug in treatment of patients with unstable angina pectoris accompanied by depression.Methods: Fifty-eight patients were randomly divided into two groups.In addition to the routine therapy,the treatment group were administered paroxetine 20-60 mg a day or xitaipulan 10-40 mg a day orally.Both groups were observed for eight weeks.Results: The symptom of depression in the treatment group was improved and the angina pectoris released(P<0.05),but no obvious effect was observed in the electrocardiogram of patients with unstable angina pectoris(P>0.05).Conclusions: Anti-depression drug may effectively relieve the symptom of depression and the angina pectoris,and improve the life quality of patients with unstable angina pectoris.
2009, 34(9): 783-785.
Abstract:
Objective: To evaluate the therapeutic efficacy of transurethral resection of the prostate(TURP) for the patients of benign prostatic hyperplasia(BPH) whose prostate weighing less than 30 g.Methods: Seventeen patients of BPH with the weight of prostate less than 30 g were received TURP and catheterization,hemostasis and anti-infection treatments after operation.Results: All of the operations were succeeded,no operation was interrupted or stopped due to the bleeding,the operation time was between 40-95 minutes,no transurethral resection related syndrome(TURS) happened in these patients who received TURP.The average score of international prostate symptom score(IPSS) of these patients was 13 one day after remove of catheterization.Conclusions: For the patients of BPH with the weight of prostate less than 30 g,the symptomatic reason of lower urinary tract should be explored before operation,and the operation methods should be selected according to patient's condition,thus the efficacy of operation would be reliable.
Objective: To evaluate the therapeutic efficacy of transurethral resection of the prostate(TURP) for the patients of benign prostatic hyperplasia(BPH) whose prostate weighing less than 30 g.Methods: Seventeen patients of BPH with the weight of prostate less than 30 g were received TURP and catheterization,hemostasis and anti-infection treatments after operation.Results: All of the operations were succeeded,no operation was interrupted or stopped due to the bleeding,the operation time was between 40-95 minutes,no transurethral resection related syndrome(TURS) happened in these patients who received TURP.The average score of international prostate symptom score(IPSS) of these patients was 13 one day after remove of catheterization.Conclusions: For the patients of BPH with the weight of prostate less than 30 g,the symptomatic reason of lower urinary tract should be explored before operation,and the operation methods should be selected according to patient's condition,thus the efficacy of operation would be reliable.
2009, 34(9): 785-787.
Abstract:
Objective: To determine the minimal motor block local analgesic concentration(MMLAC) of ropivacaine for epidural analgesia in the first stage of labor.Methods: Thirty ASA I nulliparous women were administered 10 ml bolus of epidural ropivacaine in the first stage of labor.A concentration of 0.5% ropivacaine was applied to the first woman,and the dosage to the next one was up-regulated or down-regulated one level in accordance to the previous woman's response to the concentration.The Brownlee method was used to quantify the MMLAC.Results: The minimal motor blocking concentration of epidural ropivacaine determined by sequential method was 0.673 7% in the first stage of labor,and 95% confidence interval was between 0.651 2% to 0.697 0%.Conclusions: Determination of the MMLAC of ropivacaine may guide the use of ropivacaine in the first stage of labor.
Objective: To determine the minimal motor block local analgesic concentration(MMLAC) of ropivacaine for epidural analgesia in the first stage of labor.Methods: Thirty ASA I nulliparous women were administered 10 ml bolus of epidural ropivacaine in the first stage of labor.A concentration of 0.5% ropivacaine was applied to the first woman,and the dosage to the next one was up-regulated or down-regulated one level in accordance to the previous woman's response to the concentration.The Brownlee method was used to quantify the MMLAC.Results: The minimal motor blocking concentration of epidural ropivacaine determined by sequential method was 0.673 7% in the first stage of labor,and 95% confidence interval was between 0.651 2% to 0.697 0%.Conclusions: Determination of the MMLAC of ropivacaine may guide the use of ropivacaine in the first stage of labor.
2009, 34(9): 788-789.
Abstract:
Objective: To investigate the curative effect of irbesartan/hydrochlorothiazide combination on the mild to moderate hypertension patients with left ventricular hypertrophy.Methods: By using self control,the 78 cases of mild to moderate hypertension with left ventricular hypertrophy were confirmed by echocardiography,then they were treated with irbesartan/hydrochlorothiazide combination orally two pieces once a day in the morning,and it was lasted for three months.The correlated data of left ventricle were tested by multicolor hyperacoustic Doppler before and after treatment.The left ventricular mass index(LVMI) was calculated and the changes of the LVMI and heart function parameters were analysed.Results: The systolic pressure and diastolic pressure were decreased significantly after treatment(P<0.001).The inner diameter of the left ventricular end-diastole,the thickness of the posterior left ventricular wall and the interventricular septum were decreased significantly(P<0.001).The left ventricular quality and LVMI were decreased more significantly(P<0.001).Conclusions: After three months treatment of irbesartan/hydrochlorothiazide combination,the symptom of left ventricular hypertrophy was significantly reversed in the mild to moderate hypertension patients,meanwhile the diastolic function of left ventricle was improved.It is securely and effectively.
Objective: To investigate the curative effect of irbesartan/hydrochlorothiazide combination on the mild to moderate hypertension patients with left ventricular hypertrophy.Methods: By using self control,the 78 cases of mild to moderate hypertension with left ventricular hypertrophy were confirmed by echocardiography,then they were treated with irbesartan/hydrochlorothiazide combination orally two pieces once a day in the morning,and it was lasted for three months.The correlated data of left ventricle were tested by multicolor hyperacoustic Doppler before and after treatment.The left ventricular mass index(LVMI) was calculated and the changes of the LVMI and heart function parameters were analysed.Results: The systolic pressure and diastolic pressure were decreased significantly after treatment(P<0.001).The inner diameter of the left ventricular end-diastole,the thickness of the posterior left ventricular wall and the interventricular septum were decreased significantly(P<0.001).The left ventricular quality and LVMI were decreased more significantly(P<0.001).Conclusions: After three months treatment of irbesartan/hydrochlorothiazide combination,the symptom of left ventricular hypertrophy was significantly reversed in the mild to moderate hypertension patients,meanwhile the diastolic function of left ventricle was improved.It is securely and effectively.
2009, 34(9): 790-792.
Abstract:
Objective: To summarize the technique and effect of the open reduction and internal fixation surgical operation for trimalleolar fractures.Methods: The arc-shaped inside incision was done to expose the medial malleolus and posterior malleolus.Through a straight incision in trailing edge of fibula,fractures of fibula and lateral malleolus were showed in surgery vision.Then fracture restoration and internal fixation were carried out by the sequence of posterior malleolus,medial malleolus,lateral malleolus and distal tibiofibular syndesmosis.Results: According to the criterion of AOFAS,30 patients were classified in excellent,17 in good,5 in fair.The total percentage of excellent or good effects in all of 52 cases were 90.4% after a follow-up period of 12-36 weeks.Fractures were healed up in average 14 weeks.Conclusions: For these patients with pronation and supination external rotation trimalleolar fractures,the ankles function of fractures could have effective recovered through open restoration,steady fixation and restoring the anatomy relations of the ankle joints.
Objective: To summarize the technique and effect of the open reduction and internal fixation surgical operation for trimalleolar fractures.Methods: The arc-shaped inside incision was done to expose the medial malleolus and posterior malleolus.Through a straight incision in trailing edge of fibula,fractures of fibula and lateral malleolus were showed in surgery vision.Then fracture restoration and internal fixation were carried out by the sequence of posterior malleolus,medial malleolus,lateral malleolus and distal tibiofibular syndesmosis.Results: According to the criterion of AOFAS,30 patients were classified in excellent,17 in good,5 in fair.The total percentage of excellent or good effects in all of 52 cases were 90.4% after a follow-up period of 12-36 weeks.Fractures were healed up in average 14 weeks.Conclusions: For these patients with pronation and supination external rotation trimalleolar fractures,the ankles function of fractures could have effective recovered through open restoration,steady fixation and restoring the anatomy relations of the ankle joints.
2009, 34(9): 792-794.
Abstract:
Objective: To observe the effect of simvastatin on pulse wave velocity(PWV) and ankle-brachialindex(ABI) in geriatric hypertensive patients with hyperlipemia.Methods: Eighty five patients with hypertension-hyperlipemia were randomly divided into control group(n=40) and simvastatin group(n=45),which were treated for 3 months.Systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),blood fat,PWV and ABI were measured before and after treatment.Results: Serum total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) in patients with simvastatin group were more decrease,and high-density lipoprotein cholesterol(HDL-C) was more increase.The levels of SBP,DBP and PP were markedly depressed in The both two groups,but compared with control group,the degrees of decrease of SBP,PP were more.In addition,the PWV were more visibly decreased and ABI increased after treatment than before treatment in two groups.However,compared with control group,the degree of increase in ABI with simvastatin group was more visibly.Conclusions: Simvastatin may improve the vascular function through decreaseing PWV,reducing PP and increasing ABI in geriatric hypertensive patients with hyperlipemia.
Objective: To observe the effect of simvastatin on pulse wave velocity(PWV) and ankle-brachialindex(ABI) in geriatric hypertensive patients with hyperlipemia.Methods: Eighty five patients with hypertension-hyperlipemia were randomly divided into control group(n=40) and simvastatin group(n=45),which were treated for 3 months.Systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),blood fat,PWV and ABI were measured before and after treatment.Results: Serum total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) in patients with simvastatin group were more decrease,and high-density lipoprotein cholesterol(HDL-C) was more increase.The levels of SBP,DBP and PP were markedly depressed in The both two groups,but compared with control group,the degrees of decrease of SBP,PP were more.In addition,the PWV were more visibly decreased and ABI increased after treatment than before treatment in two groups.However,compared with control group,the degree of increase in ABI with simvastatin group was more visibly.Conclusions: Simvastatin may improve the vascular function through decreaseing PWV,reducing PP and increasing ABI in geriatric hypertensive patients with hyperlipemia.
2009, 34(9): 795-796.
Abstract:
Objective: To analyze the common causes of postpartum hemorrhage and risk factors.Methods: Volume and weighing measurement of postpartum hemorrhage.Summary of the relevant factors of postpartum hemorrhage.Results: The incidence of postpartum hemorrhage was 2.88%,the mortality rate was 1.68%,the uterine atony was 75.63%,15.97% of placental factors,8.14% of soft birth canal injury.The risk factors that can cause postpartum hemorrhage were uterine factors,pregnancy complications,production times and quality of midwifery staff.Conclusions: Post-partum haemorrhage is caused by multiple risk factors,improving the quality of midwifery staff can reduce the occurrence and mortality.
Objective: To analyze the common causes of postpartum hemorrhage and risk factors.Methods: Volume and weighing measurement of postpartum hemorrhage.Summary of the relevant factors of postpartum hemorrhage.Results: The incidence of postpartum hemorrhage was 2.88%,the mortality rate was 1.68%,the uterine atony was 75.63%,15.97% of placental factors,8.14% of soft birth canal injury.The risk factors that can cause postpartum hemorrhage were uterine factors,pregnancy complications,production times and quality of midwifery staff.Conclusions: Post-partum haemorrhage is caused by multiple risk factors,improving the quality of midwifery staff can reduce the occurrence and mortality.
2009, 34(9): 797-799.
Abstract:
Objective: To investigate the application of combined spinal and epidural anesthesia with 0.75% ropivacaine in lumbar disc hemiation operation.Methods: Forty patients receiving lumbar disc hemiation operation were randomly divided into two groups.Group A was administered 0.75% ropivacaine in addition to combined spinal and epidural anesthesia(CSEA),and group B was given only epidural anesthesia.The relative parameters concerning the circulation and respiration of the two groups during the operation were recorded and compared;at the same time,the intensity of pain and muscle relaxation were observed.Results: The evaluation of the intensity of pain and muscle relaxation in group A were significantly better than that in group B(P<0.01).No significant differences were found between group A and group B in blood pressure or heart rate(P>0.05).Conclusions: The combination therapy of 0.75% ropivation and CSEA is safe and effective for patients undergoing lumbar disc hemiation operation.
Objective: To investigate the application of combined spinal and epidural anesthesia with 0.75% ropivacaine in lumbar disc hemiation operation.Methods: Forty patients receiving lumbar disc hemiation operation were randomly divided into two groups.Group A was administered 0.75% ropivacaine in addition to combined spinal and epidural anesthesia(CSEA),and group B was given only epidural anesthesia.The relative parameters concerning the circulation and respiration of the two groups during the operation were recorded and compared;at the same time,the intensity of pain and muscle relaxation were observed.Results: The evaluation of the intensity of pain and muscle relaxation in group A were significantly better than that in group B(P<0.01).No significant differences were found between group A and group B in blood pressure or heart rate(P>0.05).Conclusions: The combination therapy of 0.75% ropivation and CSEA is safe and effective for patients undergoing lumbar disc hemiation operation.
2009, 34(9): 799-801.
Abstract:
Objective: To compare the anesthetic effect of anesthsia epidural block with different concentrations of ropivacaine on elderly patients receiving thoracic surgery.Methods: Forty-five patients receiving thoracic surgery were randomly divided into normal saline group(group A),0.25% ropivacaine group(group B) and 0.5% ropivacaine group(group C),with 15 cases in each.After induction of anesthesia,group B and group C were injected 5 ml ropivacaine of corresponding concentration every 60 min to the epidural cavity,and group A were injected 5 ml saline.The MAP,HR,the time of breathing recovery,opening eyes,extubation and the side effects after anesthesia were recorded.Results: HR and MAP decreased in all the three groups after anesthesia induction(P<0.05 to P<0.01).After tracheal intubation,the HR and MAP increased significantly in group A(P<0.01),fluctuated mildly in group B(P>0.05) and decreased greatly in group C.The time of breathing recovery,opening eyes and extubation in group A was significantly longer than that in group B and group C(P<0.01),and there was no obvious difference between group B and group C(P>0.05).No nausea,vomiting or respiratory depression were observed during the operation in all the three groups.One patient in group A presented irritability.Conclusions: 0.25% ropivacaine epidural anesthesia combined with general anesthesia can be safely and effectively used in elderly patients undergoing thoracic surgery.
Objective: To compare the anesthetic effect of anesthsia epidural block with different concentrations of ropivacaine on elderly patients receiving thoracic surgery.Methods: Forty-five patients receiving thoracic surgery were randomly divided into normal saline group(group A),0.25% ropivacaine group(group B) and 0.5% ropivacaine group(group C),with 15 cases in each.After induction of anesthesia,group B and group C were injected 5 ml ropivacaine of corresponding concentration every 60 min to the epidural cavity,and group A were injected 5 ml saline.The MAP,HR,the time of breathing recovery,opening eyes,extubation and the side effects after anesthesia were recorded.Results: HR and MAP decreased in all the three groups after anesthesia induction(P<0.05 to P<0.01).After tracheal intubation,the HR and MAP increased significantly in group A(P<0.01),fluctuated mildly in group B(P>0.05) and decreased greatly in group C.The time of breathing recovery,opening eyes and extubation in group A was significantly longer than that in group B and group C(P<0.01),and there was no obvious difference between group B and group C(P>0.05).No nausea,vomiting or respiratory depression were observed during the operation in all the three groups.One patient in group A presented irritability.Conclusions: 0.25% ropivacaine epidural anesthesia combined with general anesthesia can be safely and effectively used in elderly patients undergoing thoracic surgery.
2009, 34(9): 802-803.
Abstract:
Objective: To explore the clinical effect and surgical technique of modified laparoscopic hysteromyomectomy(LM).Methods: Forty-five cases of hysteromyoma were treated using modified LM.The myoma matrix was sutured continuously with deep muscular layer and shallow muscular layer at intervals;the big myoma was resected at first,and then part of the tumor body was removed by potary cutting.Results: The LM was successful in all the 45 cases,and no case was converted to open surgery.Intraoperative blood loss was 20-180 ml,and the operation time was 50-140 min.No complications occurred.Conclusions: Modified LM is safe and effective for treatment of hysteromyoma with minimal invasion.Proper indication and suture technique are essential.
Objective: To explore the clinical effect and surgical technique of modified laparoscopic hysteromyomectomy(LM).Methods: Forty-five cases of hysteromyoma were treated using modified LM.The myoma matrix was sutured continuously with deep muscular layer and shallow muscular layer at intervals;the big myoma was resected at first,and then part of the tumor body was removed by potary cutting.Results: The LM was successful in all the 45 cases,and no case was converted to open surgery.Intraoperative blood loss was 20-180 ml,and the operation time was 50-140 min.No complications occurred.Conclusions: Modified LM is safe and effective for treatment of hysteromyoma with minimal invasion.Proper indication and suture technique are essential.
2009, 34(9): 829-830.
Abstract:
Objective: To improve the teaching quality of experimental cause of physiology for the foreign students.Methods: The preparation and execution of the experiment cause to the students abroad were summarized and analyzed.Results: The physiology experimental class was welcomed and praised by all the foreign students.Conclusions: The teaching quality is highly improved by sufficient preparation before class and proper selection of teaching modes according to the characteristics of the foreign students.
Objective: To improve the teaching quality of experimental cause of physiology for the foreign students.Methods: The preparation and execution of the experiment cause to the students abroad were summarized and analyzed.Results: The physiology experimental class was welcomed and praised by all the foreign students.Conclusions: The teaching quality is highly improved by sufficient preparation before class and proper selection of teaching modes according to the characteristics of the foreign students.
2009, 34(9): 831-833.
Abstract:
Objective: To transfer the lecture from teacher-oriented to student-oriented,focusing on students' performance.Methods: Students were encouraged to participate in the scientific innovation;conventional teaching methods were reformed and operational skills integrated with Experimental Course of Preventive Medicine.Results: Students' innovation and research abilities were greatly elevated,and they were more active by interacting with teachers.Conclusions: Teachers and students' interaction,students participation in scientific innovation and experimental integration are beneficial to teaching practice.
Objective: To transfer the lecture from teacher-oriented to student-oriented,focusing on students' performance.Methods: Students were encouraged to participate in the scientific innovation;conventional teaching methods were reformed and operational skills integrated with Experimental Course of Preventive Medicine.Results: Students' innovation and research abilities were greatly elevated,and they were more active by interacting with teachers.Conclusions: Teachers and students' interaction,students participation in scientific innovation and experimental integration are beneficial to teaching practice.
2009, 34(9): 835-837.
Abstract:
Objective: To evaluate the efficacy of evidence-based nursing in health education of children with nephrotic syndrome.Methods: Sixty-eight children with nephrotic syndrome were randomly divided into evidence-based group and control group,with 34 cases in each.Evidence-based group were asked questions in accordance to the evidence-based steps;the literature was reviewed to find scientific evidence to formulate health education programs;the health education programs were implemented and evaluated.The control group were applied conventional health education programs.The rate of recurrence,the rate of reaching the standards of growth and development,and the satisfactory degree of the two groups were observed statistically.Results: The disease recurrence rate in the evidence-based group was significantly lower than that of the control group(P<0.01);the satisfactory degree in the evidence-based group was significantly higher than that in the control group(P<0.01);and there was significant difference between the two groups in the rate of growth and development of standards(P<0.05).Conclusions: Evidence-based method can be applied to health education of children with nephrotic syndrome,which may improve the patients' satisfaction degree,reduce the relapse rate of the disease and improve the life quality of the children.
Objective: To evaluate the efficacy of evidence-based nursing in health education of children with nephrotic syndrome.Methods: Sixty-eight children with nephrotic syndrome were randomly divided into evidence-based group and control group,with 34 cases in each.Evidence-based group were asked questions in accordance to the evidence-based steps;the literature was reviewed to find scientific evidence to formulate health education programs;the health education programs were implemented and evaluated.The control group were applied conventional health education programs.The rate of recurrence,the rate of reaching the standards of growth and development,and the satisfactory degree of the two groups were observed statistically.Results: The disease recurrence rate in the evidence-based group was significantly lower than that of the control group(P<0.01);the satisfactory degree in the evidence-based group was significantly higher than that in the control group(P<0.01);and there was significant difference between the two groups in the rate of growth and development of standards(P<0.05).Conclusions: Evidence-based method can be applied to health education of children with nephrotic syndrome,which may improve the patients' satisfaction degree,reduce the relapse rate of the disease and improve the life quality of the children.
2009, 34(9): 838-840.
Abstract:
Objective: To explore the risk factors and effectiveness of secondary prevention on stroke to patient's recovery,life quality,treatment compliance.Methods: One hundred and eighty patients with stroke were divided into observation group(n=90) and control group(n=90) randomly.Health records were set up and self designed scale for assessment of risk factors of recurrence of stroke was used to assess the patient's general conditions.Individual intensified education and behavior intervention were carried out based on the evaluation in observation group;while routine therapy and essential health education were given to patients in control group.The general evaluation of the collected data was made after 3 months and 6 months.Results: In the observation group,the exactitude of mastering knowledge of diseases and correction of non-health habit and compliance were evidently higher than that in control group(P<0.01);and the rate of recurrence of stroke was lower than that in control group(P<0.05 and P<0.01).Conclusions: Secondary prevention can effectively reduce the recurrence of stroke and improve the quality of patient's life.
Objective: To explore the risk factors and effectiveness of secondary prevention on stroke to patient's recovery,life quality,treatment compliance.Methods: One hundred and eighty patients with stroke were divided into observation group(n=90) and control group(n=90) randomly.Health records were set up and self designed scale for assessment of risk factors of recurrence of stroke was used to assess the patient's general conditions.Individual intensified education and behavior intervention were carried out based on the evaluation in observation group;while routine therapy and essential health education were given to patients in control group.The general evaluation of the collected data was made after 3 months and 6 months.Results: In the observation group,the exactitude of mastering knowledge of diseases and correction of non-health habit and compliance were evidently higher than that in control group(P<0.01);and the rate of recurrence of stroke was lower than that in control group(P<0.05 and P<0.01).Conclusions: Secondary prevention can effectively reduce the recurrence of stroke and improve the quality of patient's life.
2009, 34(9): 840-842.
Abstract:
Objective: To evaluate the status of anxiety and depression of patients with breast cancer,and analyze the related factors.Methods: The self-rating anxiety scale,self-rating depression scale and a self-designed questionnaire were used to investigate 230 patients with breast cancer.Results: The incidence of anxiety and depression in patients with breast cancer were 56.09% and 49.57% respectively.The related factors included age,educational level,pay forms,the monthly income of family and tumor staging and so on.Conclusions: The incidences of anxiety and depression of patients with breast cancer are relatively higher.To improve the psychological state of them,psychological intervention should be strengthened in the perioperative period of patients with breast cancer.
Objective: To evaluate the status of anxiety and depression of patients with breast cancer,and analyze the related factors.Methods: The self-rating anxiety scale,self-rating depression scale and a self-designed questionnaire were used to investigate 230 patients with breast cancer.Results: The incidence of anxiety and depression in patients with breast cancer were 56.09% and 49.57% respectively.The related factors included age,educational level,pay forms,the monthly income of family and tumor staging and so on.Conclusions: The incidences of anxiety and depression of patients with breast cancer are relatively higher.To improve the psychological state of them,psychological intervention should be strengthened in the perioperative period of patients with breast cancer.
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