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2011 Vol. 36, No. 6
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2011, 36(6): 545-546,550.
Abstract:
Objective: To investigate the influence of maternal infection by staphylococcal enterotoxin B(SEB) during pregnancy on the development of fetal thymus. Methods: The pregnant rats at the gestational day(GD) 16 were randomly divided into two groups:the experimental group of 12 rats injected intravenously by 15 μg SEB and the control group of 12 rats by vehicle. At GD 21 the fetuses of two groups were acquired after the pregnant rats were killed,then the weights of placenta,fetal thymus and the whole fetal body were measured. The percentages of CD4+ and CD8+ T cell subsets in thymus was detected by flow cytometry. Results: Maternal infection by SEB during pregnancy decreased the weights of fetal thymus as well as the percentages of both CD4-CD8+ and CD4+ CD8+ T cells, while the percentage of CD4+ CD8-T cells was increased compared to that of the control group(P < 0.01 and P < 0.05). But the weights of placenta and the whole fetal had no difference between the two groups(P > 0.05). Conclusions: The thymus development of fetus can be affected by maternal infection by SEB during pregnancy.
Objective: To investigate the influence of maternal infection by staphylococcal enterotoxin B(SEB) during pregnancy on the development of fetal thymus. Methods: The pregnant rats at the gestational day(GD) 16 were randomly divided into two groups:the experimental group of 12 rats injected intravenously by 15 μg SEB and the control group of 12 rats by vehicle. At GD 21 the fetuses of two groups were acquired after the pregnant rats were killed,then the weights of placenta,fetal thymus and the whole fetal body were measured. The percentages of CD4+ and CD8+ T cell subsets in thymus was detected by flow cytometry. Results: Maternal infection by SEB during pregnancy decreased the weights of fetal thymus as well as the percentages of both CD4-CD8+ and CD4+ CD8+ T cells, while the percentage of CD4+ CD8-T cells was increased compared to that of the control group(P < 0.01 and P < 0.05). But the weights of placenta and the whole fetal had no difference between the two groups(P > 0.05). Conclusions: The thymus development of fetus can be affected by maternal infection by SEB during pregnancy.
2011, 36(6): 547-550.
Abstract:
Objective: To investigate the effect of arsenic trioxide(As2O3) on expressions of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in HL-60 cells. Methods: HL-60 cells were treated with different concentrations of As2O3 for 48 hours. Semiquantitative reverse transcription polymerase chain reaction(RT-PCR) was used to examine the expressions of MMP-2 and MMP-9 mRNA. Western blot was used to evaluate the productions of MMP-2 and MMP-9 proteins. Results: The expressions of MMP-2 and MMP-9 mRNA in HL-60 cells were decreased after treated with As2O3. There were statistical significances between 5.0 and 7.5 μmol/L As2O3 groups and control group(P < 0.05-P < 0.01). The productions of MMP-2 and MMP-9 proteins were reduced dose-dependently when treated with As2O3. There was statistical significance between each experimental group and control group(P < 0.05-P < 0.01). Conclusions: As2O3 can inhibit the expressions of MMP-2 and MMP-9 in HL-60 cells. This effect might be one of the molecule mechanisms of As2O3 in the treatment of leukemia.
Objective: To investigate the effect of arsenic trioxide(As2O3) on expressions of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in HL-60 cells. Methods: HL-60 cells were treated with different concentrations of As2O3 for 48 hours. Semiquantitative reverse transcription polymerase chain reaction(RT-PCR) was used to examine the expressions of MMP-2 and MMP-9 mRNA. Western blot was used to evaluate the productions of MMP-2 and MMP-9 proteins. Results: The expressions of MMP-2 and MMP-9 mRNA in HL-60 cells were decreased after treated with As2O3. There were statistical significances between 5.0 and 7.5 μmol/L As2O3 groups and control group(P < 0.05-P < 0.01). The productions of MMP-2 and MMP-9 proteins were reduced dose-dependently when treated with As2O3. There was statistical significance between each experimental group and control group(P < 0.05-P < 0.01). Conclusions: As2O3 can inhibit the expressions of MMP-2 and MMP-9 in HL-60 cells. This effect might be one of the molecule mechanisms of As2O3 in the treatment of leukemia.
2011, 36(6): 551-553.
Abstract:
Objective: To investigate the effect of transient limb ischemic postconditioning (LPostC) on mouse against focal cerebral ischemia-reperfusion(I/R) injury. Methods: Thirty two male mice were randomly divided into four groups,8 in each group:Sham group,I/R group,I/R + PostC group and I/R + LPostC groups. Twenty-four hours after the reperfusion,the neurologic deficit scores were recorded according to Longa standard and the brains were obtained to measure superoxide dismutase (SOD) activity and malondialdehyde(MDA) content. Results: Compared with I/R group,the neurologic deficit scores of I/R + LPostC group and I/R + PostC group were significantly decreased(P < 0.01). Compared with Sham group,the content of cerebral tissue MDA was markedly increased,and the activity of SOD was decreased significantly in I/R group. Compared with I/R group,in I/R + LPostC group and I/R + PostC group,the activities of SOD in the cerebral tissues were enhanced(P < 0.05),and the contents of MDA in the cerebral tissues were decreased(P < 0.05). Conclusions: LPostC can attenuate focal cerebral ischemic reperfusion induced brain injury, improve neurological behavior and increase the ability of resisting brain injury. The protective mechanism of LPostC may be related to reduce reactive oxygen species production and promote its clearance in brain injury.
Objective: To investigate the effect of transient limb ischemic postconditioning (LPostC) on mouse against focal cerebral ischemia-reperfusion(I/R) injury. Methods: Thirty two male mice were randomly divided into four groups,8 in each group:Sham group,I/R group,I/R + PostC group and I/R + LPostC groups. Twenty-four hours after the reperfusion,the neurologic deficit scores were recorded according to Longa standard and the brains were obtained to measure superoxide dismutase (SOD) activity and malondialdehyde(MDA) content. Results: Compared with I/R group,the neurologic deficit scores of I/R + LPostC group and I/R + PostC group were significantly decreased(P < 0.01). Compared with Sham group,the content of cerebral tissue MDA was markedly increased,and the activity of SOD was decreased significantly in I/R group. Compared with I/R group,in I/R + LPostC group and I/R + PostC group,the activities of SOD in the cerebral tissues were enhanced(P < 0.05),and the contents of MDA in the cerebral tissues were decreased(P < 0.05). Conclusions: LPostC can attenuate focal cerebral ischemic reperfusion induced brain injury, improve neurological behavior and increase the ability of resisting brain injury. The protective mechanism of LPostC may be related to reduce reactive oxygen species production and promote its clearance in brain injury.
2011, 36(6): 554-556.
Abstract:
Objective: To investigate the effects of compound Hugan decoction on conA-induced liver injury in mice. Methods: BALb/c mice were randomly divided into six groups,10 in each,which included normal,liver injury,biphenyldimethylesterate treatment 1.5 mg·kg-1·d-1 and compound Hugan decoction treatment(7 g·kg-1·d-1,14 g·kg-1·d-1,28 g·kg-1·d-1) groups. The animal model of liver injury was established by intravenous injection of ConA (12.5 mg/kg) in BALb/c mice. The serum level of alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP), γ-glutamyltransferase(GGT), and hyaluronidase(HA) were assayed by spectrophotometer. Results: Compound Hugan decoction significantly decreased the concentration of serum transaminases(ALT,AST,ALP,GGT) and it showed a dose-dependent manner between the range of 7-28 g·kg-1·d-1. Conclusions: Compound Hugan decoction performs protective effect against ConA-induced liver injury in mice. Such protective effects might be related to the increase of antioxidant enzyme activity and the promotion of free radicals elimination.
Objective: To investigate the effects of compound Hugan decoction on conA-induced liver injury in mice. Methods: BALb/c mice were randomly divided into six groups,10 in each,which included normal,liver injury,biphenyldimethylesterate treatment 1.5 mg·kg-1·d-1 and compound Hugan decoction treatment(7 g·kg-1·d-1,14 g·kg-1·d-1,28 g·kg-1·d-1) groups. The animal model of liver injury was established by intravenous injection of ConA (12.5 mg/kg) in BALb/c mice. The serum level of alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP), γ-glutamyltransferase(GGT), and hyaluronidase(HA) were assayed by spectrophotometer. Results: Compound Hugan decoction significantly decreased the concentration of serum transaminases(ALT,AST,ALP,GGT) and it showed a dose-dependent manner between the range of 7-28 g·kg-1·d-1. Conclusions: Compound Hugan decoction performs protective effect against ConA-induced liver injury in mice. Such protective effects might be related to the increase of antioxidant enzyme activity and the promotion of free radicals elimination.
2011, 36(6): 557-560.
Abstract:
Objective: To explore the changes of carotid intima-media thickness(IMT) and vascular endothelium function in people with impaired fasting glucose(IFG) as well as the risk factors. Methods: The anthropometric variables,fasting blood glucose(FBG),2-hour postprandial blood glucose (PBG), fasting blood insulin (FINS), postprandial blood insulin (PINS), systolic pressure (SBP), diastolic pressure(DBP),blood lipid and other clinical parameters were measured in 30 controls with normal glucose tolerance(NGT) and 45 people with impaired fasting glucose(IFG). The carotid IMT was measured by color Doppler ultrasound,the blood endothelin 1 (ET-1) was tested by enzyme-linked immune sorbent assay (ELISA) and the blood nitric oxide(NO) by nitrate reductase assay in all the subjects. Results: There were significant differences in the levels of IMT,ET-1 and NO between IFG group and NGT group(P < 0.01). According to linear correlation analysis, IMT showed positive correlation with body mass index (BMI), SBP, blood NO, triglyceride(TG),ET-1,FINS,HOMA insulin resistance index (HOMA-IR) and DBP respectively(P < 0.05-P < 0.01); the level of blood NO showed positive correlation with IMT,SBP,ET-1,TG,FINS,HOMA-IR,HOMA-β cell function index(HOMA-β) and DBP, respectively(P < 0.05-P < 0.01). The level of blood ET-1 showed positive correlation with IMT,SBP,NO,BMI,FINS,HOMA-IR, HOMA-β and TG,respectively(P < 0.05-P < 0.01). According to multiple regression analysis,the risk factors of IMT were NO,TG, FBG and ET-1 in sequence,the risk factors of blood ET-1 were blood NO and PBG,and the risk factors of blood NO were SBP and ET-1 in sequence. Conclusions: The IMT,blood ET-1 and NO increase greatly in adults with impaired fasting glucose,and their vascular endothelial function has changed significantly compared with that of people with NGT. Early intervention may improve the islet function of IFG population and thus reduces the genesis of diabetes and atherosclerosis.
Objective: To explore the changes of carotid intima-media thickness(IMT) and vascular endothelium function in people with impaired fasting glucose(IFG) as well as the risk factors. Methods: The anthropometric variables,fasting blood glucose(FBG),2-hour postprandial blood glucose (PBG), fasting blood insulin (FINS), postprandial blood insulin (PINS), systolic pressure (SBP), diastolic pressure(DBP),blood lipid and other clinical parameters were measured in 30 controls with normal glucose tolerance(NGT) and 45 people with impaired fasting glucose(IFG). The carotid IMT was measured by color Doppler ultrasound,the blood endothelin 1 (ET-1) was tested by enzyme-linked immune sorbent assay (ELISA) and the blood nitric oxide(NO) by nitrate reductase assay in all the subjects. Results: There were significant differences in the levels of IMT,ET-1 and NO between IFG group and NGT group(P < 0.01). According to linear correlation analysis, IMT showed positive correlation with body mass index (BMI), SBP, blood NO, triglyceride(TG),ET-1,FINS,HOMA insulin resistance index (HOMA-IR) and DBP respectively(P < 0.05-P < 0.01); the level of blood NO showed positive correlation with IMT,SBP,ET-1,TG,FINS,HOMA-IR,HOMA-β cell function index(HOMA-β) and DBP, respectively(P < 0.05-P < 0.01). The level of blood ET-1 showed positive correlation with IMT,SBP,NO,BMI,FINS,HOMA-IR, HOMA-β and TG,respectively(P < 0.05-P < 0.01). According to multiple regression analysis,the risk factors of IMT were NO,TG, FBG and ET-1 in sequence,the risk factors of blood ET-1 were blood NO and PBG,and the risk factors of blood NO were SBP and ET-1 in sequence. Conclusions: The IMT,blood ET-1 and NO increase greatly in adults with impaired fasting glucose,and their vascular endothelial function has changed significantly compared with that of people with NGT. Early intervention may improve the islet function of IFG population and thus reduces the genesis of diabetes and atherosclerosis.
2011, 36(6): 561-563.
Abstract:
Objective: To investigate the characteristics and clinical significance of immunophenotype in acute myeloid leukemia (AML). Methods: Immunophenotype was carried out in 145 patients with AML using flow cytometry. Results: The expression of MPO, CD13,HLA-DR,CD33 and CD34 was 93.1%,90.3%,77.2%,71.7% and 70.3%,respectively. CD14 was expressed only in the M4 and M5 subtype. The lymphoid antigen expression was most commonly observed in CD7 (34.5%),especially in M5 subtype and CD19 (10.3%); CD2 was expressed only in part of M3 subtype. Two cases of acute hybrid leukemia were detected,expressing both myeloid and lymphoid associated antigen. Conclusions: MPO, CD13 and CD33 are sensitive myeloid associated antigens. The expression of CD7,CD19 and CD2,as well as the immunophenotype by flow cytometry,is of great value in diagnosis and prognosis of AML.
Objective: To investigate the characteristics and clinical significance of immunophenotype in acute myeloid leukemia (AML). Methods: Immunophenotype was carried out in 145 patients with AML using flow cytometry. Results: The expression of MPO, CD13,HLA-DR,CD33 and CD34 was 93.1%,90.3%,77.2%,71.7% and 70.3%,respectively. CD14 was expressed only in the M4 and M5 subtype. The lymphoid antigen expression was most commonly observed in CD7 (34.5%),especially in M5 subtype and CD19 (10.3%); CD2 was expressed only in part of M3 subtype. Two cases of acute hybrid leukemia were detected,expressing both myeloid and lymphoid associated antigen. Conclusions: MPO, CD13 and CD33 are sensitive myeloid associated antigens. The expression of CD7,CD19 and CD2,as well as the immunophenotype by flow cytometry,is of great value in diagnosis and prognosis of AML.
2011, 36(6): 564-567.
Abstract:
Objective: To study the protective effects of sufentanil preconditioning on myocardial ischemia-reperfusion injury induced by cardiopulmonary bypass(CPB) in cardiac valve replacement patients. Methods: Forty-five patients scheduled for elective cardiac valve replacement with CPB were randomly divided into three groups(n=15),control group(group A),patients received 3 episodes of 5 minutes normal saline infusion at 1 ml/min at 5 minutes interval before aorta clamping; low-dose sufentanil preconditioning group (group B) and high-dose sufentanil preconditioning group(group C) patients that received 3 episodes of 5 minutes sufentanil infusion at 0.2,0.4 μg·kg-1·min-1 at 5 min interval before aorta clamping,respectively. Plasma levels of cardiac troponin I(cTnI) and creatine phosphokinase isoenzyme(CK-MB) before induction of anesthesia(T1),4(T2),8(T3),24(T4) and 48 hours(T5) after aorta unclamping were measured. The hemodynamics and postoperative assistant ventilation,24 hours postoperation contraction score,drainage volumn and stay in the intensive care unit were also recorded. Results: In group A,plasma cTnI levels at T2,T3,T4 and T5 were higher than that at T 1 (P < 0.01),reached the peak level at T3,then declined at T4. In group B and C plasma cTnI levels at T2,T3,and T4 were higher than that at T1 (P < 0.05-P < 0.01),and reached the peak level at T2,then declined to normal range at T5. Plasma cTnI at T 2,T3,T4 and T5 in group B and C were lower than that in group A(P < 0.05-P < 0.01),respectively. Plasma CK-MB levels at T2, T 3,T4 and T5 were higher than that at T1 in three groups(P < 0.05-P < 0.01). There were no significant differences in plasma CK-MB levels among three groups at T2,T3,but the values were lower in group B and C than that in group A at T4,T5 (P < 0.05-P < 0.01). Intubation time, the requirement for inotropics, the volume of wound drainage in first postoperative day and ICU stay time in group B and group C were significant less than that in group A. Conclusions: Sufentanil preconditioning could relieve myocardial injury induced by CPB in cardiac valve replacement patients.
Objective: To study the protective effects of sufentanil preconditioning on myocardial ischemia-reperfusion injury induced by cardiopulmonary bypass(CPB) in cardiac valve replacement patients. Methods: Forty-five patients scheduled for elective cardiac valve replacement with CPB were randomly divided into three groups(n=15),control group(group A),patients received 3 episodes of 5 minutes normal saline infusion at 1 ml/min at 5 minutes interval before aorta clamping; low-dose sufentanil preconditioning group (group B) and high-dose sufentanil preconditioning group(group C) patients that received 3 episodes of 5 minutes sufentanil infusion at 0.2,0.4 μg·kg-1·min-1 at 5 min interval before aorta clamping,respectively. Plasma levels of cardiac troponin I(cTnI) and creatine phosphokinase isoenzyme(CK-MB) before induction of anesthesia(T1),4(T2),8(T3),24(T4) and 48 hours(T5) after aorta unclamping were measured. The hemodynamics and postoperative assistant ventilation,24 hours postoperation contraction score,drainage volumn and stay in the intensive care unit were also recorded. Results: In group A,plasma cTnI levels at T2,T3,T4 and T5 were higher than that at T 1 (P < 0.01),reached the peak level at T3,then declined at T4. In group B and C plasma cTnI levels at T2,T3,and T4 were higher than that at T1 (P < 0.05-P < 0.01),and reached the peak level at T2,then declined to normal range at T5. Plasma cTnI at T 2,T3,T4 and T5 in group B and C were lower than that in group A(P < 0.05-P < 0.01),respectively. Plasma CK-MB levels at T2, T 3,T4 and T5 were higher than that at T1 in three groups(P < 0.05-P < 0.01). There were no significant differences in plasma CK-MB levels among three groups at T2,T3,but the values were lower in group B and C than that in group A at T4,T5 (P < 0.05-P < 0.01). Intubation time, the requirement for inotropics, the volume of wound drainage in first postoperative day and ICU stay time in group B and group C were significant less than that in group A. Conclusions: Sufentanil preconditioning could relieve myocardial injury induced by CPB in cardiac valve replacement patients.
2011, 36(6): 568-570.
Abstract:
Objective: To explore the efficacy of surgical therapy for primary vulvar cancer and the relative factors influencing the prognosis. Methods: Of the 51 patients having received operation for vulvar cancer,7 accepted radical local excision,28 traditional radical vulvectomy plus inguinofemoral lymphadenetomy and 16 modified radical vulvectomy plus inguinofemoral lymphadenetomy. SPSS software was used to analyze the effects of different surgical procedures and the prognostic factors. Results: According to the International Federation of Gynecologyand Obstetrics 2009,31 patients were classified as stage Ⅰ,5 as stageⅡ,12 as stage Ⅲ and 3 as stage Ⅳ. The overall 5-year survival rate was 80.4%. All the 7 patients accepted radical local excision surgery survived more than 5 years; the 5-year survival rates of the traditional radical vulvectomy group and the modified radical vulvectomy group were 78.6% and 75.0%,respectively. The difference was not significant(P > 0.05). The patients with positive inguinofemoral lymph nodes who had received chemoradiation therapy or radiation therapy demonstrated no great difference in 5-year survival rate(P > 0.05). Conclusions: Surgery is the most definite means for vulvar cancer. Early diagnosis and treatment are essential to improve the 5-yearival rate of the patients with vulvar cancer. Comprehensive and individualized therapy should be adopted for treatment of vulvar cancer.
Objective: To explore the efficacy of surgical therapy for primary vulvar cancer and the relative factors influencing the prognosis. Methods: Of the 51 patients having received operation for vulvar cancer,7 accepted radical local excision,28 traditional radical vulvectomy plus inguinofemoral lymphadenetomy and 16 modified radical vulvectomy plus inguinofemoral lymphadenetomy. SPSS software was used to analyze the effects of different surgical procedures and the prognostic factors. Results: According to the International Federation of Gynecologyand Obstetrics 2009,31 patients were classified as stage Ⅰ,5 as stageⅡ,12 as stage Ⅲ and 3 as stage Ⅳ. The overall 5-year survival rate was 80.4%. All the 7 patients accepted radical local excision surgery survived more than 5 years; the 5-year survival rates of the traditional radical vulvectomy group and the modified radical vulvectomy group were 78.6% and 75.0%,respectively. The difference was not significant(P > 0.05). The patients with positive inguinofemoral lymph nodes who had received chemoradiation therapy or radiation therapy demonstrated no great difference in 5-year survival rate(P > 0.05). Conclusions: Surgery is the most definite means for vulvar cancer. Early diagnosis and treatment are essential to improve the 5-yearival rate of the patients with vulvar cancer. Comprehensive and individualized therapy should be adopted for treatment of vulvar cancer.
2011, 36(6): 571-573.
Abstract:
Objective: To compare the therapeutic effects of the suspension laryngoscope in nosal endoscope surgery and euthyphoria surgery for treatment of vocal cord polyps,and to discuss the choice of surgical procedures. Methods: The clinical data of 80 patients with vocal cord polyps were analyzed retrospectively. Forty-one of the cases received the resection using the suspension laryngoscope with the aid of nosal endoscope(nosal endoscope group) and 39 cases received euthyphoria surgery(euthyphoria group). All the cases were followed up for 3 months. The clinical effects of the two procedures were compared. Results: The clinical effect of nosal endoscope group was significantly better than that of the euthyphoria group (P < 0.05). Conclusions: The procedure of using the suspension laryngoscope with the aid of nosal endoscope is superior to the euthyphoria procedure in treatment of vocal cord polyps,and is worth popularizing.
Objective: To compare the therapeutic effects of the suspension laryngoscope in nosal endoscope surgery and euthyphoria surgery for treatment of vocal cord polyps,and to discuss the choice of surgical procedures. Methods: The clinical data of 80 patients with vocal cord polyps were analyzed retrospectively. Forty-one of the cases received the resection using the suspension laryngoscope with the aid of nosal endoscope(nosal endoscope group) and 39 cases received euthyphoria surgery(euthyphoria group). All the cases were followed up for 3 months. The clinical effects of the two procedures were compared. Results: The clinical effect of nosal endoscope group was significantly better than that of the euthyphoria group (P < 0.05). Conclusions: The procedure of using the suspension laryngoscope with the aid of nosal endoscope is superior to the euthyphoria procedure in treatment of vocal cord polyps,and is worth popularizing.
2011, 36(6): 573-574.
Abstract:
Objective: To observe the effect of lymphocyte immunization therapy for recurrent spontaneous abortion(RSA). Methods: Fifty-eight cases of unexplained RSA detected with negative blocking antibody were treated with peripheral blood lymphocytes from spouse for active immunotherapy. Results: Forty-nine patients(84.5%) were pregnanted successfully. Three patients were failed(still in treatment),2 cases were lost to follow up after the third treatment,one case was ectopic pregnancy,and 3 cases were aborted(including 1 case of twin pregnancy to six months). Conclusions: Allogeneic immunotherapy on patients with unexplained RSA may be a safe effective treatment,it can furtherly improve the success rate of pregnancy.
Objective: To observe the effect of lymphocyte immunization therapy for recurrent spontaneous abortion(RSA). Methods: Fifty-eight cases of unexplained RSA detected with negative blocking antibody were treated with peripheral blood lymphocytes from spouse for active immunotherapy. Results: Forty-nine patients(84.5%) were pregnanted successfully. Three patients were failed(still in treatment),2 cases were lost to follow up after the third treatment,one case was ectopic pregnancy,and 3 cases were aborted(including 1 case of twin pregnancy to six months). Conclusions: Allogeneic immunotherapy on patients with unexplained RSA may be a safe effective treatment,it can furtherly improve the success rate of pregnancy.
2011, 36(6): 575-576.
Abstract:
Objective: To summarize the experience in diagnosis and treatment of hepatic trauma. Methods: The data of 31 cases of liver trauma were analyzed retrospectively. Twenty-nine cases were managed by surgical therapy and 2 by non-surgical therapy. Results: Twenty-nine cases were immediately diagnosed by diagnostic peritoneal paracentesis. One died and 30 were cured. After the operation, hemobilia ocurred in 1 case,stress ulcer in 1 case,liver abscess in 1 case and diaphragm infection in 1 case. Conclusions: Image examination combined with diagnostic peritoneal paracentesis are important means for diagnosis of hepatic trauma. The choice of therapy patterns depends on the type and stage of the hepatic trauma.
Objective: To summarize the experience in diagnosis and treatment of hepatic trauma. Methods: The data of 31 cases of liver trauma were analyzed retrospectively. Twenty-nine cases were managed by surgical therapy and 2 by non-surgical therapy. Results: Twenty-nine cases were immediately diagnosed by diagnostic peritoneal paracentesis. One died and 30 were cured. After the operation, hemobilia ocurred in 1 case,stress ulcer in 1 case,liver abscess in 1 case and diaphragm infection in 1 case. Conclusions: Image examination combined with diagnostic peritoneal paracentesis are important means for diagnosis of hepatic trauma. The choice of therapy patterns depends on the type and stage of the hepatic trauma.
2011, 36(6): 577-578,581.
Abstract:
Objective: To investigate the correlation between plasminogen activator inhibitor-1(PAI-1) and diabetic foot,and to provide references for the prevention and treatment of diabetic foot(DF). Methods: Forty-two patients with DF were included in the DF group, 38 diabetes mellitus(DM) with non-DF were DMNDF group,and 45 volunteers were selected as control. The plasma concentration of PAI-1,glycosylated hemoglobin (HbA1c) and C reactive protein (CRP) were compared among the groups. Results: There were statistically significant differences among the DF group,control group and DMNDF groups in PAI-1,HbA1c and CRP(P < 0.05-P < 0.01). Conclusions: PAI-1 is obviously correlated with the DF. Active interference and therapy for type 2 DM could decrease the PAI-1,increase the fibrinolytic activity and inhibit the progression of atherosclerosis,thus reducing the incidence of the DF.
Objective: To investigate the correlation between plasminogen activator inhibitor-1(PAI-1) and diabetic foot,and to provide references for the prevention and treatment of diabetic foot(DF). Methods: Forty-two patients with DF were included in the DF group, 38 diabetes mellitus(DM) with non-DF were DMNDF group,and 45 volunteers were selected as control. The plasma concentration of PAI-1,glycosylated hemoglobin (HbA1c) and C reactive protein (CRP) were compared among the groups. Results: There were statistically significant differences among the DF group,control group and DMNDF groups in PAI-1,HbA1c and CRP(P < 0.05-P < 0.01). Conclusions: PAI-1 is obviously correlated with the DF. Active interference and therapy for type 2 DM could decrease the PAI-1,increase the fibrinolytic activity and inhibit the progression of atherosclerosis,thus reducing the incidence of the DF.
2011, 36(6): 579-581.
Abstract:
Objective: To observe the curative effect of proximal femoral nail-A anti-rotation (PFNA) in treating multisegmental femoral fracture of proximal femur by a new interlocking nail. Methods: Twenty-one cases with multisegmental of femur fractures of proximal femur had been treated with PFNA. The surgery was operated on orthopedic lower limb automatic traction bed,PENA was fulfilled under C-arm fluoroscopy monitoring. Results: The 21 cases were followed up for 6 to 24 months. All cases were well union. The average healing time was 4.8 months,except two patients' recovery was delayed. However,all of them had healed 6 months after PFNA was removed,and the function of hip and knee were well recovered. According to the recovery evaluation criteria of national femoral fracture,12 cases were excellent,7 were good,and 2 were poor. The acceptance rate was 90.5%. The major nail in one case was slightly curved,but the function was not affected. Conclusions: PFNA is a reliable fixation method for multisegmental fracture of femur from subtrochanteric to femoral condyle with less trauma and blood loss.
Objective: To observe the curative effect of proximal femoral nail-A anti-rotation (PFNA) in treating multisegmental femoral fracture of proximal femur by a new interlocking nail. Methods: Twenty-one cases with multisegmental of femur fractures of proximal femur had been treated with PFNA. The surgery was operated on orthopedic lower limb automatic traction bed,PENA was fulfilled under C-arm fluoroscopy monitoring. Results: The 21 cases were followed up for 6 to 24 months. All cases were well union. The average healing time was 4.8 months,except two patients' recovery was delayed. However,all of them had healed 6 months after PFNA was removed,and the function of hip and knee were well recovered. According to the recovery evaluation criteria of national femoral fracture,12 cases were excellent,7 were good,and 2 were poor. The acceptance rate was 90.5%. The major nail in one case was slightly curved,but the function was not affected. Conclusions: PFNA is a reliable fixation method for multisegmental fracture of femur from subtrochanteric to femoral condyle with less trauma and blood loss.
2011, 36(6): 582-584.
Abstract:
Objective: To observe the efficacy of monosialotetrahexosylganglioside(GM1) in treatment of neonatal hypoxic-ischemic encephalopathy(HIE). Methods: Forty-four cases of neonatal HIE were evenly divided into two groups. The control group were administered the conventional therapy and citicoline; the treatment group,in addition to the therapy of the control group,received GM1. The clinical manifestation and recovery of the children in the two groups were observed and recorded. The neonatal behavioral neurological assessment (NBNA) scores were compared between the two groups before and after treatment. Results: The total response rates of the treatment group and the control group were 95.45% and 63.64%,respectively (P < 0.05). The NBNA scores in the treatment group were higher than that in the control group at 10-14 days during the treatment (P < 0.01). Conclusions: Early application of neonatal GM1 can effectively improve the nervous system dysfunction of the children with HIE.
Objective: To observe the efficacy of monosialotetrahexosylganglioside(GM1) in treatment of neonatal hypoxic-ischemic encephalopathy(HIE). Methods: Forty-four cases of neonatal HIE were evenly divided into two groups. The control group were administered the conventional therapy and citicoline; the treatment group,in addition to the therapy of the control group,received GM1. The clinical manifestation and recovery of the children in the two groups were observed and recorded. The neonatal behavioral neurological assessment (NBNA) scores were compared between the two groups before and after treatment. Results: The total response rates of the treatment group and the control group were 95.45% and 63.64%,respectively (P < 0.05). The NBNA scores in the treatment group were higher than that in the control group at 10-14 days during the treatment (P < 0.01). Conclusions: Early application of neonatal GM1 can effectively improve the nervous system dysfunction of the children with HIE.
2011, 36(6): 584-586.
Abstract:
Objective: To study the clinical and pathological characteristics of breast plasma cell neoplasms as well as the diagnosis and differential diagnosis of it. Methods: Two cases of breast plasma cell neoplasms were analyzed pathologically,and the changes were observed using immunohistochemical method. The related literature was reviewed. Results: One case had primary plasma cell neoplasms on both sides of the breast,and the other was primary breast plasma blastoma. The lump presented no obvious clinical manifestation. Under microscope,most neoplastic plasma cells were similar to normal plasma cells; unusual and untypical tumor cells as well as mitoses were able to be seen. Plasma blastoma displayed proliferating features on large circle cells and ovoid cells which spread widely; vesicular nucleus was in the center of it and nucleolus was obvious; mitoses were easy to see. Two cases showed CD138,CD38,multiple myeloma oncogene-1 and heavy chain IgM. The first case showed light chain κ and the second showed light chain λ. Plasma cell neoplasms showed 20% positive staining for Ki 67, and plasma blastoma showed 70% positive staining for Ki-67. Conclusions: Pathological diagnosis of breast plasma cell neoplasm bases on the tissue shape and immunological manifestation. It must be distinguished from plasma cell mastitis and infiltrating lobular carcinoma. Surgical operation combined with radiotherapy may achieve better treatment results.
Objective: To study the clinical and pathological characteristics of breast plasma cell neoplasms as well as the diagnosis and differential diagnosis of it. Methods: Two cases of breast plasma cell neoplasms were analyzed pathologically,and the changes were observed using immunohistochemical method. The related literature was reviewed. Results: One case had primary plasma cell neoplasms on both sides of the breast,and the other was primary breast plasma blastoma. The lump presented no obvious clinical manifestation. Under microscope,most neoplastic plasma cells were similar to normal plasma cells; unusual and untypical tumor cells as well as mitoses were able to be seen. Plasma blastoma displayed proliferating features on large circle cells and ovoid cells which spread widely; vesicular nucleus was in the center of it and nucleolus was obvious; mitoses were easy to see. Two cases showed CD138,CD38,multiple myeloma oncogene-1 and heavy chain IgM. The first case showed light chain κ and the second showed light chain λ. Plasma cell neoplasms showed 20% positive staining for Ki 67, and plasma blastoma showed 70% positive staining for Ki-67. Conclusions: Pathological diagnosis of breast plasma cell neoplasm bases on the tissue shape and immunological manifestation. It must be distinguished from plasma cell mastitis and infiltrating lobular carcinoma. Surgical operation combined with radiotherapy may achieve better treatment results.
2011, 36(6): 587-588,591.
Abstract:
Objective: To assess the value of neurophysiological monitoring in preserving the facial nerve in microsurgery for acoustic neuroma. Methods: Forty-six patients with acoustic neuroma were divided into monitoring group and non-monitoring group. The tumor was removed under the microscope without intraoperative facial nerve monitoring in 22 cases and with intraoperative monitoring in 24 cases. All the patients were followed up. Results: House-Brackmann system was used to evaluate the function of the facial nerve 3 months after the operation. Among the 24 cases in monitoring group,grade Ⅰ was observed in 21 cases,grade Ⅱ in 2 cases and grade Ⅲ in 1 case; among the 22 cases in non monitoring group,grade Ⅰ was observed in 13 cases,grade Ⅱ in 5 cases,grade Ⅲ in 2 cases and grade Ⅴin 2 cases. The difference was significant(P < 0.05). Conclusions: Neurophysiological monitoring may effectively preserve the facial nerve function in microsurgery for acoustic neuroma.
Objective: To assess the value of neurophysiological monitoring in preserving the facial nerve in microsurgery for acoustic neuroma. Methods: Forty-six patients with acoustic neuroma were divided into monitoring group and non-monitoring group. The tumor was removed under the microscope without intraoperative facial nerve monitoring in 22 cases and with intraoperative monitoring in 24 cases. All the patients were followed up. Results: House-Brackmann system was used to evaluate the function of the facial nerve 3 months after the operation. Among the 24 cases in monitoring group,grade Ⅰ was observed in 21 cases,grade Ⅱ in 2 cases and grade Ⅲ in 1 case; among the 22 cases in non monitoring group,grade Ⅰ was observed in 13 cases,grade Ⅱ in 5 cases,grade Ⅲ in 2 cases and grade Ⅴin 2 cases. The difference was significant(P < 0.05). Conclusions: Neurophysiological monitoring may effectively preserve the facial nerve function in microsurgery for acoustic neuroma.
2011, 36(6): 589-591.
Abstract:
Objective: To investigate the clinical therapy for early-onset severe preeclampsia. Methods: The clinical data of 81 patients with early-onset severe preeclampsia and their 85 neonates were analyzed retrospectively. The cases were divided into three groups according to the onset gestation age. Group A included 9 cases between 24-27+6 weeks,group B 46 cases between 28-31+6 weeks and group C 26 cases between 32-34 weeks. The general condition,complication and outcome of both mothers and infants were observed. Results: The gestation age was prolonged about (10.0 ±3.1) days in group A,(13.7 ±5.2) days in group B and (12.6 ±3.5) days in group C,respectively. There were no significant differences in clinical symptoms or complications among the three groups(P > 0.05). The neonatal asphyxia rate and perinatal infant mortality in the three groups declined with the gestation age. And the differences were statistically significant(P < 0.05-P < 0.01). Conclusions: During the expectant treatment,the condition of maternity and fetus should be closely monitored,and pregnancy termination should be decided timely.
Objective: To investigate the clinical therapy for early-onset severe preeclampsia. Methods: The clinical data of 81 patients with early-onset severe preeclampsia and their 85 neonates were analyzed retrospectively. The cases were divided into three groups according to the onset gestation age. Group A included 9 cases between 24-27+6 weeks,group B 46 cases between 28-31+6 weeks and group C 26 cases between 32-34 weeks. The general condition,complication and outcome of both mothers and infants were observed. Results: The gestation age was prolonged about (10.0 ±3.1) days in group A,(13.7 ±5.2) days in group B and (12.6 ±3.5) days in group C,respectively. There were no significant differences in clinical symptoms or complications among the three groups(P > 0.05). The neonatal asphyxia rate and perinatal infant mortality in the three groups declined with the gestation age. And the differences were statistically significant(P < 0.05-P < 0.01). Conclusions: During the expectant treatment,the condition of maternity and fetus should be closely monitored,and pregnancy termination should be decided timely.
2011, 36(6): 592-593.
Abstract:
Objective: To investigate the combination of reconstruction plate,screw,Babcock needle and thread tension in treating humeral condylar fracture. Methods: Fifteen patients suffered C-type humeral condylar fractures were treated with pressure hollow screw,Babcock needle,steel wire combined with reconstruction plate to reconstruct humeral condylars. For those with sevier defects, autogenous iliac bone grafting,and early post-operative exercises were used. Results: All patients were followed up for 12 to 36 months. The fracture healing time was from 2.1 to 7.2 months. According to the modified Cassebaum scoring system of elbow joint function, there were 5 excellent cases,7 good cases,2 fair case and 1 poor case; the excellent and good rate was 80.00%. Conclusions: Composite fixation of plate,screw,Babcock needle and thread tension is consistent with biomechanical principles,basically realized the humeral condylar reconstruction. Multi-bit,multi-dimensional space pressure fixation,and early exercise can improve the recovery elbow joint function.
Objective: To investigate the combination of reconstruction plate,screw,Babcock needle and thread tension in treating humeral condylar fracture. Methods: Fifteen patients suffered C-type humeral condylar fractures were treated with pressure hollow screw,Babcock needle,steel wire combined with reconstruction plate to reconstruct humeral condylars. For those with sevier defects, autogenous iliac bone grafting,and early post-operative exercises were used. Results: All patients were followed up for 12 to 36 months. The fracture healing time was from 2.1 to 7.2 months. According to the modified Cassebaum scoring system of elbow joint function, there were 5 excellent cases,7 good cases,2 fair case and 1 poor case; the excellent and good rate was 80.00%. Conclusions: Composite fixation of plate,screw,Babcock needle and thread tension is consistent with biomechanical principles,basically realized the humeral condylar reconstruction. Multi-bit,multi-dimensional space pressure fixation,and early exercise can improve the recovery elbow joint function.
2011, 36(6): 594-595.
Abstract:
Objective: To study the curative effects of upper respiratory stenosis surgery in combination with continuous positive airway pressure(CPAP) in treatment of obstructive sleep apnea syndrome(OSAS). Methods: Eighty OSAS patients were romdomly divided into two groups:combined modality therapy group and control group. The control group received the surgery on the upper respiratory stenosis of nasal and pharynx cavity; the combined modality therapy group received surgery on the stenosis of nasal and pharynx cavity on the basis of accurate judgment of the upper respiratory obstructive flat with the assistance of CPAP therapy. Results: All the cases were followed up fro 6-12 months. The outcomes were assessed by polysomnogruphy. In the combination therapy group,the effects were excellent in 19 cases,fair in 16 cases and invalid in 5 cases. The total response rate was 87.5%. In the control group,the effect was excellent in 7 cases,fair in 18 cases and invalid in 15 cases. The total response rate was 62.5%. The difference was significant(P < 0.05). Conclusions: The combination therapy of upper respiratory stenosis surgery and CPAP has significant advantages in treatment of OSAS and is worth popularizing.
Objective: To study the curative effects of upper respiratory stenosis surgery in combination with continuous positive airway pressure(CPAP) in treatment of obstructive sleep apnea syndrome(OSAS). Methods: Eighty OSAS patients were romdomly divided into two groups:combined modality therapy group and control group. The control group received the surgery on the upper respiratory stenosis of nasal and pharynx cavity; the combined modality therapy group received surgery on the stenosis of nasal and pharynx cavity on the basis of accurate judgment of the upper respiratory obstructive flat with the assistance of CPAP therapy. Results: All the cases were followed up fro 6-12 months. The outcomes were assessed by polysomnogruphy. In the combination therapy group,the effects were excellent in 19 cases,fair in 16 cases and invalid in 5 cases. The total response rate was 87.5%. In the control group,the effect was excellent in 7 cases,fair in 18 cases and invalid in 15 cases. The total response rate was 62.5%. The difference was significant(P < 0.05). Conclusions: The combination therapy of upper respiratory stenosis surgery and CPAP has significant advantages in treatment of OSAS and is worth popularizing.
Clinical significance of anatomizing recurrent laryngeal nerve and its branches during thyroidectomy
2011, 36(6): 596-597,599.
Abstract:
Objective: To explore the clinical significance of anatomizing recurrent laryngeal nerve (RLN) and its branches during thyroidectomy. Methods: One hundred and five sides of RLN anatomized during 95 cases of thyroidectomy were retrospectively analyzed. Results: Ninety seven sides(92.38%) of the 105 RLN anatomized bifurcated into the laryngeal branch and extra-laryngeal branch. Six sides(5.71%) of the RLN gave off one branch. Two sides (1.91%) of the RLN gave off three branches. The lengths of branches were 0.4-2.5 cm. One case had postoperatively transient hoarseness. Conclusions: There are branches and other anatomical features of the RLN. Correct identification and safe dissection of the RLN are essential in thyroid surgery.
Objective: To explore the clinical significance of anatomizing recurrent laryngeal nerve (RLN) and its branches during thyroidectomy. Methods: One hundred and five sides of RLN anatomized during 95 cases of thyroidectomy were retrospectively analyzed. Results: Ninety seven sides(92.38%) of the 105 RLN anatomized bifurcated into the laryngeal branch and extra-laryngeal branch. Six sides(5.71%) of the RLN gave off one branch. Two sides (1.91%) of the RLN gave off three branches. The lengths of branches were 0.4-2.5 cm. One case had postoperatively transient hoarseness. Conclusions: There are branches and other anatomical features of the RLN. Correct identification and safe dissection of the RLN are essential in thyroid surgery.
2011, 36(6): 598-599.
Abstract:
Objective: To investigate the common complications in plasmapheresis for treatment of severe hepatitis. Methods: The clinical data of 58 cases of severe hepatitis complication treated by plasmapheresis were analyzed retrospectively. Results: All the 58 cases were performed the therapy for 202 times. The incidence of complication was 54.5%,among which,the numbness of the face and head accounted for 22.8%,skin itching 17.3% and decline of blood pressure 5.9%. Conclusions: Complications are quite common in the performance of plasmapheresis but usually slight,which can be alleviated after proper treatment.
Objective: To investigate the common complications in plasmapheresis for treatment of severe hepatitis. Methods: The clinical data of 58 cases of severe hepatitis complication treated by plasmapheresis were analyzed retrospectively. Results: All the 58 cases were performed the therapy for 202 times. The incidence of complication was 54.5%,among which,the numbness of the face and head accounted for 22.8%,skin itching 17.3% and decline of blood pressure 5.9%. Conclusions: Complications are quite common in the performance of plasmapheresis but usually slight,which can be alleviated after proper treatment.
2011, 36(6): 600-601,605.
Abstract:
Objective: To investigate the effect of reduced glutathione on oxidative stress in diabetic ketoacidosis(DKA) patients. Methods: Forty-seven cases of DKA patients were divided into two groups randomly:conventional treatment group and plus reduced glutathione treatment group. The levels of superoxide dismutase(SOD),total antioxidant capacity(TAC),malondialdehyde(MDA), advanced oxidation protein products(AOPP) of the two groups were compared before and after treatment. Results: After treatment by plus reduced glutathione,the content of SOD,TAC were increased significantly when compared with that in the conventional group(P < 0.01),however,the level of AOPP was decreased significantly(P < 0.01). Conclusions: Reduced glutathione could reduce the level of oxidative stress in DKA,and thus protect the body.
Objective: To investigate the effect of reduced glutathione on oxidative stress in diabetic ketoacidosis(DKA) patients. Methods: Forty-seven cases of DKA patients were divided into two groups randomly:conventional treatment group and plus reduced glutathione treatment group. The levels of superoxide dismutase(SOD),total antioxidant capacity(TAC),malondialdehyde(MDA), advanced oxidation protein products(AOPP) of the two groups were compared before and after treatment. Results: After treatment by plus reduced glutathione,the content of SOD,TAC were increased significantly when compared with that in the conventional group(P < 0.01),however,the level of AOPP was decreased significantly(P < 0.01). Conclusions: Reduced glutathione could reduce the level of oxidative stress in DKA,and thus protect the body.
2011, 36(6): 602-605.
Abstract:
Objective: To analyze the features of metabolic syndrome (MS) in adolescents,and to explore the correlation between obesity and MS so as to prevent obesity and MS in children. Methods: Nine hundred twenty-one students aged from 7-18 were selected from the primary schools and middle schools in Bengbu city. The height,weight,waist circumference,hip circumference,blood pressure, TC,TG,HDL-C,LDL-C,FPG,UA and hs-CRP of the children were measured and compared. Results: MS was detected in 128 of the students. Among them,three cases were in the normal weight group(0.9%),30 in the obesity group(11.9%) and 95 in the overweight group(28.4%). The difference was significant among the three groups(P < 0.01). The rate of MS differed significantly between the male and the female students(P < 0.01). The prevalence of high blood pressure,central obesity,WHR,WHtR,low HDL-C,high TG and high FPG in the overweight group and the obese group were significantly higher than that in the normal weight group (P < 0.05-P < 0.01). The FPG and TC had no significant differences between the over -weight group and the normal group(P > 0.05),while other factors were significantly different among the three groups(P < 0.05-P < 0.01). Conclusions: The prevalence and risk factors of MS increase along with the rise of body weight in the adolescents.
Objective: To analyze the features of metabolic syndrome (MS) in adolescents,and to explore the correlation between obesity and MS so as to prevent obesity and MS in children. Methods: Nine hundred twenty-one students aged from 7-18 were selected from the primary schools and middle schools in Bengbu city. The height,weight,waist circumference,hip circumference,blood pressure, TC,TG,HDL-C,LDL-C,FPG,UA and hs-CRP of the children were measured and compared. Results: MS was detected in 128 of the students. Among them,three cases were in the normal weight group(0.9%),30 in the obesity group(11.9%) and 95 in the overweight group(28.4%). The difference was significant among the three groups(P < 0.01). The rate of MS differed significantly between the male and the female students(P < 0.01). The prevalence of high blood pressure,central obesity,WHR,WHtR,low HDL-C,high TG and high FPG in the overweight group and the obese group were significantly higher than that in the normal weight group (P < 0.05-P < 0.01). The FPG and TC had no significant differences between the over -weight group and the normal group(P > 0.05),while other factors were significantly different among the three groups(P < 0.05-P < 0.01). Conclusions: The prevalence and risk factors of MS increase along with the rise of body weight in the adolescents.
2011, 36(6): 606-608.
Abstract:
Objective: To evaluate the efficacy of 3-dimensional conformal radiotherapy (3DCRT) combined with concurrent chemotherapy in management of esophageal carcinoma. Methods: From Feb. 2006 to Aug. 2007,31 patients with esophageal carcinoma were treated by 3DCRT at a dose of 1.8-2 Gy/f (55-65 Gy in total); at the same time, cisplatin 30 mg/m2 was administered intravenously on the first day of each week until the end of the radiotherapy. After the therapy,chemotherapy regimen of cisplatin 20 mg plus tegafur 1.0 g were administered on day 1 to 5,every 28 days for two cycles. Results: Complete relief was observed in 22 cases, partial relief in 7 cases and no response in 2 cases,the overall response rate reached 93%; the food intake obstruction was relieved in 97% of the cases; the 1,2 and 3-year local control rates were 88%,51% and 40%,respectively; the 1,2 and 3-year survival rates were 93%,66% and 58%,respectively. Acute radiations esoph-agitis occurred in 100% of the cases,and 15% of them were at a grade of ≥ 3; leucopenia was observed in 56% of the cases,and 34% of them were at a grade of ≥ 3. Conclusions: 3DCRT combined with chemotherapy is an effective and well-tolerated regimen for treatment of patients with esophageal cancer.
Objective: To evaluate the efficacy of 3-dimensional conformal radiotherapy (3DCRT) combined with concurrent chemotherapy in management of esophageal carcinoma. Methods: From Feb. 2006 to Aug. 2007,31 patients with esophageal carcinoma were treated by 3DCRT at a dose of 1.8-2 Gy/f (55-65 Gy in total); at the same time, cisplatin 30 mg/m2 was administered intravenously on the first day of each week until the end of the radiotherapy. After the therapy,chemotherapy regimen of cisplatin 20 mg plus tegafur 1.0 g were administered on day 1 to 5,every 28 days for two cycles. Results: Complete relief was observed in 22 cases, partial relief in 7 cases and no response in 2 cases,the overall response rate reached 93%; the food intake obstruction was relieved in 97% of the cases; the 1,2 and 3-year local control rates were 88%,51% and 40%,respectively; the 1,2 and 3-year survival rates were 93%,66% and 58%,respectively. Acute radiations esoph-agitis occurred in 100% of the cases,and 15% of them were at a grade of ≥ 3; leucopenia was observed in 56% of the cases,and 34% of them were at a grade of ≥ 3. Conclusions: 3DCRT combined with chemotherapy is an effective and well-tolerated regimen for treatment of patients with esophageal cancer.
2011, 36(6): 608-609.
Abstract:
Objective: To observe the clinical curative effect and safety of aerosol inhaled budesonide combined with ambroxol for children with acute laryngitis. Methods: Seventy-one children with acute laryngitis were randomly divided into treatment group and control group. The children in treatment group (32 cases) were cured with aerosol inhalation of budesonide and ambroxol with air compress pump nebuliser,and others in control group(39 cases) were treated with intravenous drip of dexamethasone. Results: The symptoms and signs dispeared significantly faster in the treatment group when compared with that of control group(P < 0.01). The total effective rate of the treatment group was 96.9%,the control group was 74.4% (P < 0.05). Conclusions: The treatment of aerosol inhaled of budesonide combined with ambroxol for children with acute laryngitis has greater efficacy and fewer side effects.
Objective: To observe the clinical curative effect and safety of aerosol inhaled budesonide combined with ambroxol for children with acute laryngitis. Methods: Seventy-one children with acute laryngitis were randomly divided into treatment group and control group. The children in treatment group (32 cases) were cured with aerosol inhalation of budesonide and ambroxol with air compress pump nebuliser,and others in control group(39 cases) were treated with intravenous drip of dexamethasone. Results: The symptoms and signs dispeared significantly faster in the treatment group when compared with that of control group(P < 0.01). The total effective rate of the treatment group was 96.9%,the control group was 74.4% (P < 0.05). Conclusions: The treatment of aerosol inhaled of budesonide combined with ambroxol for children with acute laryngitis has greater efficacy and fewer side effects.
2011, 36(6): 610-611.
Abstract:
Objective: To investigate the effect and toxicity of pemetrexed plus cisplatin in treatment of advanced-stage non-small cell lung cancer(NSCLC) in the elderly. Methods: Thirty-two chemotherapy-naive patients with stage Ⅲ-Ⅳ NSCLC who had received at least 2 cycles of pemetrexed/cisplatin therapy were reviewed retrospectively. The recent response and the toxicity were observed. Results: Of the 32 patients,complete response was found in 1 case,partial response in 13 cases,the disease was stable in 11 cases and progressive in 7 cases. The overall response rate was 43.8%. The median progression-free survival was 5.2 months. The incidence of hematologic grade Ⅲ/Ⅳ toxicities was low, and the main non-hematologic toxicities were nausea and alopecia. Conclusions: Pemetrexed/cisplatin therapy is effective and safe for treatment of elder patients with advanced-stage NSCLC.
Objective: To investigate the effect and toxicity of pemetrexed plus cisplatin in treatment of advanced-stage non-small cell lung cancer(NSCLC) in the elderly. Methods: Thirty-two chemotherapy-naive patients with stage Ⅲ-Ⅳ NSCLC who had received at least 2 cycles of pemetrexed/cisplatin therapy were reviewed retrospectively. The recent response and the toxicity were observed. Results: Of the 32 patients,complete response was found in 1 case,partial response in 13 cases,the disease was stable in 11 cases and progressive in 7 cases. The overall response rate was 43.8%. The median progression-free survival was 5.2 months. The incidence of hematologic grade Ⅲ/Ⅳ toxicities was low, and the main non-hematologic toxicities were nausea and alopecia. Conclusions: Pemetrexed/cisplatin therapy is effective and safe for treatment of elder patients with advanced-stage NSCLC.
2011, 36(6): 612-614.
Abstract:
Objective: To observe and summarize the therapeutic effects and complications of different surgical procedures for treatment of hypospadia so as to provide basis for patients to choose a suitable pattern. Methods: Different surgical procedures were applied to 48 patients with hypospadia. Duckett was adopted by 23 cases,Denis-Browne 3 cases,Duplay 10 cases,MAGPI 1 case, Duckett + Duplay 3 cases,scrotal septal vascular pediclen flap 3 cases and Hodgson 5 cases. The success rate and the complication of each procedure were analyzed retrospectively. Results: Of the 23 cases treated by Duckett,one-stage success was achieved in 18 cases, urinary fistula occurred in 3 cases,anastomotic stricture in one case and skin edge necrosis in one case; of the 3 cases treated by DenisBrowne,2 cases achieved successful results and 1 developed urethral stricture; of the 10 cases adopting Duplay,one-stage success was achieved in 7 cases and urinary fistula occurred in 3 cases; the operation was successful in the one case treated by MAGP; of the 3 cases adopting Duckett + Duplay,the operation was successful in 1 case,urinary fistula occurred in 1case and anastomotic stricture in 1 case; of the 3 cases treated by scrotal septal vascular pediclenflap,successful result was achieved in 2 cases and urinary fistula occurred in one case; of the 5 cases adopting Hodgson,4 cases achieved good results and urinary fistula occurred in 1 case. Conclusions: Different surgical procedures should be applied to different types of hypospadia. To most patients receiving the therapy for the first time,Duckett and Hodgson procedures should be taken as the first choice; patients receiving the penis diorthosis surgery for the second time may choose Duplay or Denis-Browne; patients having experienced failed operations or lacking external genital organ skin source should consider using dissociation substitution tissues(cheek mucous membrane,tongue mucous membrane and so on).
Objective: To observe and summarize the therapeutic effects and complications of different surgical procedures for treatment of hypospadia so as to provide basis for patients to choose a suitable pattern. Methods: Different surgical procedures were applied to 48 patients with hypospadia. Duckett was adopted by 23 cases,Denis-Browne 3 cases,Duplay 10 cases,MAGPI 1 case, Duckett + Duplay 3 cases,scrotal septal vascular pediclen flap 3 cases and Hodgson 5 cases. The success rate and the complication of each procedure were analyzed retrospectively. Results: Of the 23 cases treated by Duckett,one-stage success was achieved in 18 cases, urinary fistula occurred in 3 cases,anastomotic stricture in one case and skin edge necrosis in one case; of the 3 cases treated by DenisBrowne,2 cases achieved successful results and 1 developed urethral stricture; of the 10 cases adopting Duplay,one-stage success was achieved in 7 cases and urinary fistula occurred in 3 cases; the operation was successful in the one case treated by MAGP; of the 3 cases adopting Duckett + Duplay,the operation was successful in 1 case,urinary fistula occurred in 1case and anastomotic stricture in 1 case; of the 3 cases treated by scrotal septal vascular pediclenflap,successful result was achieved in 2 cases and urinary fistula occurred in one case; of the 5 cases adopting Hodgson,4 cases achieved good results and urinary fistula occurred in 1 case. Conclusions: Different surgical procedures should be applied to different types of hypospadia. To most patients receiving the therapy for the first time,Duckett and Hodgson procedures should be taken as the first choice; patients receiving the penis diorthosis surgery for the second time may choose Duplay or Denis-Browne; patients having experienced failed operations or lacking external genital organ skin source should consider using dissociation substitution tissues(cheek mucous membrane,tongue mucous membrane and so on).
2011, 36(6): 615-616,620.
Abstract:
Objective: To evaluate the diagnosis and treatment of the placenta accreta on the postoperative scar after previous caesarean section in late pregnancy. Methods: A retrospective study was conducted in 9 cases with placenta accreta on the postoperative scar after previous caesarean section in late pregnancy from Jan. 2000 to Jul. 2010. Results: Five cases were performed termination of pregnancy after conservative treatment during 32-35 weeks pregnancy and 4 cases were performed cesarean section after adequate preoperative preparation. All the 9 cases suffered from postpartum hemorrhage. One case with placental adherence underwent uterine artery ligation,and the other 6 cases with placenta accreta and 2 cases with placenta percreta received hysterectomy. No death occurred in the pregnant or lying-in women. Premature birth was observed in 5 infants and full term birth in 2 infants; perinatal deaths occurred in 2 infants. Conclusions: Accurate diagnosis and effective therapeutic procedure are essential for treatment of placenta accreta on the postoperative scar after previous caesarean section in late pregnancy.
Objective: To evaluate the diagnosis and treatment of the placenta accreta on the postoperative scar after previous caesarean section in late pregnancy. Methods: A retrospective study was conducted in 9 cases with placenta accreta on the postoperative scar after previous caesarean section in late pregnancy from Jan. 2000 to Jul. 2010. Results: Five cases were performed termination of pregnancy after conservative treatment during 32-35 weeks pregnancy and 4 cases were performed cesarean section after adequate preoperative preparation. All the 9 cases suffered from postpartum hemorrhage. One case with placental adherence underwent uterine artery ligation,and the other 6 cases with placenta accreta and 2 cases with placenta percreta received hysterectomy. No death occurred in the pregnant or lying-in women. Premature birth was observed in 5 infants and full term birth in 2 infants; perinatal deaths occurred in 2 infants. Conclusions: Accurate diagnosis and effective therapeutic procedure are essential for treatment of placenta accreta on the postoperative scar after previous caesarean section in late pregnancy.
2011, 36(6): 617-620.
Abstract:
Objective: To study the relevant factors for anus reservation in radical resection of ultra-low-rectal carcinoma through Logistic regression analysis, and to discuss the indications and surgical procedures. Methods: Thirty-six patients with rectal tumors within 5 cm above the anal verge were treated by surgical procedures from Apr. 2007 to Mar. 2008 in our department. The gender,age, location and size of the tumor,degree of differentiation,Dukes stage,operation methods,preoperative neoadjuvant therapy,and whether or not retainning the anus before operation were studied through Logistic regression analysis. Results: The results indicated that the above four factors were the major relevant factors for anus reservation in radical resection of ultra-low-rectal carcinoma(P=0.048-P=0.011). Conclusions: The clinical staging of the patients should be precisely assessed before operation. Patients with the tumors located within 4-5 cm above the anal verge or before Dukes stage C should receive laparoscopic radical operation; and patients with the tumors located below 4 cm above the anal verge should select multi-mode therapies,to achieve radical cure and anal reservation.
Objective: To study the relevant factors for anus reservation in radical resection of ultra-low-rectal carcinoma through Logistic regression analysis, and to discuss the indications and surgical procedures. Methods: Thirty-six patients with rectal tumors within 5 cm above the anal verge were treated by surgical procedures from Apr. 2007 to Mar. 2008 in our department. The gender,age, location and size of the tumor,degree of differentiation,Dukes stage,operation methods,preoperative neoadjuvant therapy,and whether or not retainning the anus before operation were studied through Logistic regression analysis. Results: The results indicated that the above four factors were the major relevant factors for anus reservation in radical resection of ultra-low-rectal carcinoma(P=0.048-P=0.011). Conclusions: The clinical staging of the patients should be precisely assessed before operation. Patients with the tumors located within 4-5 cm above the anal verge or before Dukes stage C should receive laparoscopic radical operation; and patients with the tumors located below 4 cm above the anal verge should select multi-mode therapies,to achieve radical cure and anal reservation.
2011, 36(6): 621-624.
Abstract:
Objective: To study the roles of brain natriuretic peptide(BNP) in diagnosis and prognostic evaluation of patients with acute coronary syndrome(ACS). Methods: The levels of BNP were detected in 54 patients with acute myocardial infarction(AMI), 35 patients with unstable angina pectoris(UAP),20 patients with stable angina pectoris(SAP) and 20 healthy volunteers as controls. The correlations were compared between the number of impaired coronary arteries,the lesions of left main coronary artery,the Gensini scores of coronary artery and the levels of BNP respectively. The mortality of the patients with ACS in hospital at 30 days and 3 months, and the major adverse cardiac events(MACE),cardiogenic death, re-myocardial infarction, recurrent angina,consequential heart failure and the composite endpoint rates of readmission were analyzed. Results: The levels of BNP in group AMI and group UAP were significantly higher than those in group SAP and controls(P < 0.01),and the level of BNP in group AMI was significantly higher than it in group UAP(P < 0.01). Multivariate logistic regression analysis showed that,the level of plasma BNP was independent with the risk factors of coronary heart disease,such as age,gender,family history,smoking, hyperlipidemia,high blood pressure,diabetes,and so on, but it was associated with mortality and rates MACE(P < 0.05-P < 0.01). Conclusions: The levels of BNP in patients with ACS increase significantly and are associated with degrees of coronary artery disease and myocardial ischemia. The change of plasma BNP is an independent predictor for mortality and incidence of MACE in hospital at 30 days and 3 months among ACS patients.
Objective: To study the roles of brain natriuretic peptide(BNP) in diagnosis and prognostic evaluation of patients with acute coronary syndrome(ACS). Methods: The levels of BNP were detected in 54 patients with acute myocardial infarction(AMI), 35 patients with unstable angina pectoris(UAP),20 patients with stable angina pectoris(SAP) and 20 healthy volunteers as controls. The correlations were compared between the number of impaired coronary arteries,the lesions of left main coronary artery,the Gensini scores of coronary artery and the levels of BNP respectively. The mortality of the patients with ACS in hospital at 30 days and 3 months, and the major adverse cardiac events(MACE),cardiogenic death, re-myocardial infarction, recurrent angina,consequential heart failure and the composite endpoint rates of readmission were analyzed. Results: The levels of BNP in group AMI and group UAP were significantly higher than those in group SAP and controls(P < 0.01),and the level of BNP in group AMI was significantly higher than it in group UAP(P < 0.01). Multivariate logistic regression analysis showed that,the level of plasma BNP was independent with the risk factors of coronary heart disease,such as age,gender,family history,smoking, hyperlipidemia,high blood pressure,diabetes,and so on, but it was associated with mortality and rates MACE(P < 0.05-P < 0.01). Conclusions: The levels of BNP in patients with ACS increase significantly and are associated with degrees of coronary artery disease and myocardial ischemia. The change of plasma BNP is an independent predictor for mortality and incidence of MACE in hospital at 30 days and 3 months among ACS patients.
2011, 36(6): 625-627.
Abstract:
Objective: To explore the correlation between high-sensitivity C reactivity protein (hs-CRP) and atrial fibrillation. Methods: Sixty-one patients with nonvalvular atrial fibrillation were divided into two groups:paroxysmal atrial fibrillation(PAF) group (30 cases) and subtained atrial fibrillation (SAF) and control group(the other 31 cases with sinus rhythm acted). The serum hs-CRP levels and the left atrial internal diameter of all the cases were measured by immunochemistry method and echocardiography. Results: The hs-CRP level of PAF group and SAF group was significantly higher than that of the control (P < 0.05 to P < 0.01); the serum hsCRP level and the left atrial internal diameter of SAF group were significantly higher than that of PAF group(P < 0.01),and the serum hs-CRP level was positively related with the left atrial internal diameter(P < 0.05). Conclusions: The level of serum hs-CRP increases significantly in patients with atrial fibrillation, which indicaates that the inflammatory reation may promote the occurrence and maintenance of atrial fibrillation.
Objective: To explore the correlation between high-sensitivity C reactivity protein (hs-CRP) and atrial fibrillation. Methods: Sixty-one patients with nonvalvular atrial fibrillation were divided into two groups:paroxysmal atrial fibrillation(PAF) group (30 cases) and subtained atrial fibrillation (SAF) and control group(the other 31 cases with sinus rhythm acted). The serum hs-CRP levels and the left atrial internal diameter of all the cases were measured by immunochemistry method and echocardiography. Results: The hs-CRP level of PAF group and SAF group was significantly higher than that of the control (P < 0.05 to P < 0.01); the serum hsCRP level and the left atrial internal diameter of SAF group were significantly higher than that of PAF group(P < 0.01),and the serum hs-CRP level was positively related with the left atrial internal diameter(P < 0.05). Conclusions: The level of serum hs-CRP increases significantly in patients with atrial fibrillation, which indicaates that the inflammatory reation may promote the occurrence and maintenance of atrial fibrillation.
2011, 36(6): 627-629.
Abstract:
Objective: To study the pathogenesis of thrombocytopenia and its optimal treatment in perinatal period. Methods: Based on the treatment of primary disease, platelet counts > 50×109/L and asymptomatic patients were given oral iron-supplementary, creatinine,folic acid and vitamins routinely. As for patients with platelet counts < 50×109/L,they were treated with glucocorticoid, platelet and immunoglobulin in perinatal period, and the caesarean section was considered. Results: The main causes of thrombocytopenia included pregnancy itself in 24 cases,preeclampsia in 11 cases,idiopathic thrombocytopenic purpura in 4 cases,liver diseases in 2 cases,and aplastic anemia in 1 case of all cases. For all cases,vaginal delivery and cesarean section were 23 and 19 cases,respectively. Postpartum hemorrhage happened in 3 cases,and eonatal thrombocytopenia happened in 1 case. Conclusions: Many reasons may cause thrombocytopenia during pregnancy. Based on treatments for the cause,Application of platelet agent,corticosteroid and immune globulin is effective treatment for severe thrombocytopenia during pregnancy.
Objective: To study the pathogenesis of thrombocytopenia and its optimal treatment in perinatal period. Methods: Based on the treatment of primary disease, platelet counts > 50×109/L and asymptomatic patients were given oral iron-supplementary, creatinine,folic acid and vitamins routinely. As for patients with platelet counts < 50×109/L,they were treated with glucocorticoid, platelet and immunoglobulin in perinatal period, and the caesarean section was considered. Results: The main causes of thrombocytopenia included pregnancy itself in 24 cases,preeclampsia in 11 cases,idiopathic thrombocytopenic purpura in 4 cases,liver diseases in 2 cases,and aplastic anemia in 1 case of all cases. For all cases,vaginal delivery and cesarean section were 23 and 19 cases,respectively. Postpartum hemorrhage happened in 3 cases,and eonatal thrombocytopenia happened in 1 case. Conclusions: Many reasons may cause thrombocytopenia during pregnancy. Based on treatments for the cause,Application of platelet agent,corticosteroid and immune globulin is effective treatment for severe thrombocytopenia during pregnancy.
2011, 36(6): 640-642.
Abstract:
Objective: To study the MR images of Rathke's cleft cyst so as to improve the diagnosis of this disease. Methods: The enhanced MR images of 17 patients with Rathke's cleft cyst were retrospectively analyzed. Results: The Rathke's cleft cyst was located in the intrasellar region in 12 cases,in both sella and superasellar regions in 4 cases and in the suprasellar region in 1 case. The lesions were ovoid (13/17) or dumbell shaped (4/17),all of which were cystic. Intracystic nodule was found in 1 case. Six of the cases presented hypointense on T1WI and hyperintense on T2WIs,8 cases isointense on T1WI and hyperintense on T2WI,2 cases isointense on T1WI and T2WI,and 3 cases hyperintense on T1WI and T2WI. Partial linear contrast enhancement on the cystic wall was seen in 3 cases,but no enhancement was found in the intracystic nodule. Conclusions: The MRI features of the Rathke's cleft cyst were as follows:most of the lesions were located in the intrasellar region or involving both intra-and suprasellar regions,manifesting iso or hyper intensity on T1WI but no enhancement after contrast injection. These will be of help to the diagnosis of Rathke's cleft cyst before surgery.
Objective: To study the MR images of Rathke's cleft cyst so as to improve the diagnosis of this disease. Methods: The enhanced MR images of 17 patients with Rathke's cleft cyst were retrospectively analyzed. Results: The Rathke's cleft cyst was located in the intrasellar region in 12 cases,in both sella and superasellar regions in 4 cases and in the suprasellar region in 1 case. The lesions were ovoid (13/17) or dumbell shaped (4/17),all of which were cystic. Intracystic nodule was found in 1 case. Six of the cases presented hypointense on T1WI and hyperintense on T2WIs,8 cases isointense on T1WI and hyperintense on T2WI,2 cases isointense on T1WI and T2WI,and 3 cases hyperintense on T1WI and T2WI. Partial linear contrast enhancement on the cystic wall was seen in 3 cases,but no enhancement was found in the intracystic nodule. Conclusions: The MRI features of the Rathke's cleft cyst were as follows:most of the lesions were located in the intrasellar region or involving both intra-and suprasellar regions,manifesting iso or hyper intensity on T1WI but no enhancement after contrast injection. These will be of help to the diagnosis of Rathke's cleft cyst before surgery.
2011, 36(6): 643-644.
Abstract:
Objective: To assess the value of ultrasonography in diagnosis of papillary thyroid carcinoma (PTC). Methods: The ultrasonography and color Dopple's flowmeter image features of 57 cases of PTC diagnosed before surgery and proved by histopathology were analyzed retrospectively. Results: The ultrasound images revealed that 47 of the cases had hypoechoic nodules in the parenchyma of the thyroid and 10 had solid and cystic nodules; 50 cases presented irregular shape and no capsule, 34 cases nodular microcalcification and 41 cases rich internal blood supply or blood flow disturbance. Forty-eight cases preoperative ultrasonography in the diagnosis and postoperative diagnosis accord,compliance rate was 84.21%. Conclusions: Ultrasonographic features that can provide useful information for early diagnosis and surgical therapy,that are of great value in management of PTC.
Objective: To assess the value of ultrasonography in diagnosis of papillary thyroid carcinoma (PTC). Methods: The ultrasonography and color Dopple's flowmeter image features of 57 cases of PTC diagnosed before surgery and proved by histopathology were analyzed retrospectively. Results: The ultrasound images revealed that 47 of the cases had hypoechoic nodules in the parenchyma of the thyroid and 10 had solid and cystic nodules; 50 cases presented irregular shape and no capsule, 34 cases nodular microcalcification and 41 cases rich internal blood supply or blood flow disturbance. Forty-eight cases preoperative ultrasonography in the diagnosis and postoperative diagnosis accord,compliance rate was 84.21%. Conclusions: Ultrasonographic features that can provide useful information for early diagnosis and surgical therapy,that are of great value in management of PTC.
2011, 36(6): 645-646,649.
Abstract:
Objective: To discuss the X-ray manifestation and differential diagnosis of newborns with lung frequent hemorrhoid. Methods: The supine anteroposterior chest films of 60 neonates with lung frequent hemorrhoid were retrospectively analyzed. Among them,additional supine lateral chest film with horizontal projection was performed in 25 cases and spiral CT scanning in 4 cases. Results: The X-ray demonstrated that 38 cases had pneumothorax, 18 pneumomediastinum, 16 interstitial emphysema and 2 subcutaneous gas accumulation in the chest or the neck. No pneumatosis or pneumoperitoneum were detected. Two or more frequent hemorrhoidage performances were displayed in 20 cases; aspiration pneumonia was found in 52 cases; wet-lung disease was detected in 3 cases,1 of which was caused by high pressure of the breathing machine. Conclusions: X-ray photograph is most reliable in diagnosis of the neonate lung frequent hemorrhoid,and CT can help to confirm the location,scope and extent of the disease.
Objective: To discuss the X-ray manifestation and differential diagnosis of newborns with lung frequent hemorrhoid. Methods: The supine anteroposterior chest films of 60 neonates with lung frequent hemorrhoid were retrospectively analyzed. Among them,additional supine lateral chest film with horizontal projection was performed in 25 cases and spiral CT scanning in 4 cases. Results: The X-ray demonstrated that 38 cases had pneumothorax, 18 pneumomediastinum, 16 interstitial emphysema and 2 subcutaneous gas accumulation in the chest or the neck. No pneumatosis or pneumoperitoneum were detected. Two or more frequent hemorrhoidage performances were displayed in 20 cases; aspiration pneumonia was found in 52 cases; wet-lung disease was detected in 3 cases,1 of which was caused by high pressure of the breathing machine. Conclusions: X-ray photograph is most reliable in diagnosis of the neonate lung frequent hemorrhoid,and CT can help to confirm the location,scope and extent of the disease.
2011, 36(6): 647-649.
Abstract:
Objective: To evaluate the effect of problem-based learning(PBL) in teaching pediatric cardiovascular system disease. Methods: Through flipping a coin,medical undergraduate students,were divided into PBL group(pharmacy Grade 2008,n=107) and lecture-based learning(LBL) group(preventive medicine Grade 2008,n=104),respectively. For two groups,corresponding teaching method was conducted in the chapter of pediatric cardiovascular system disease. The attitudes towards PBL and LBL were investigated by questionnaire survey. Theory test scores were compared between both groups. Results: The ratio of approval attitude towards PBL in PBL group was significantly higher than the ratio of approval attitude towards LBL in LBL group(88.8% vs 59.6%,P < 0.01). Theory test scores were significantly higher in PBL group than in LBL group(P < 0.01). Conclusions: PBL is superior to LBL,which suggests that PBL teaching method can be used in theoretical course teaching of pediatric cardiovascular system disease.
Objective: To evaluate the effect of problem-based learning(PBL) in teaching pediatric cardiovascular system disease. Methods: Through flipping a coin,medical undergraduate students,were divided into PBL group(pharmacy Grade 2008,n=107) and lecture-based learning(LBL) group(preventive medicine Grade 2008,n=104),respectively. For two groups,corresponding teaching method was conducted in the chapter of pediatric cardiovascular system disease. The attitudes towards PBL and LBL were investigated by questionnaire survey. Theory test scores were compared between both groups. Results: The ratio of approval attitude towards PBL in PBL group was significantly higher than the ratio of approval attitude towards LBL in LBL group(88.8% vs 59.6%,P < 0.01). Theory test scores were significantly higher in PBL group than in LBL group(P < 0.01). Conclusions: PBL is superior to LBL,which suggests that PBL teaching method can be used in theoretical course teaching of pediatric cardiovascular system disease.
2011, 36(6): 650-652.
Abstract:
Objective: To explore physical diagnostics teaching method and improve teaching quality. Methods: This article summarized some aspects in details about how to improve the teaching quality of physical diagnostics, including emphasizing the importance,combining theory and practice,harmonizing the relationship of teacher,student and patient,enriching teaching methods, reforming examination method and so on. One hundred and sixty college students were investigated by filling out questionnaires for evaluation of teaching effect. Results: The results of questionnaires showed that the physical diagnostics teaching reform had been well accepted by students. Conclusions: The teaching quality could be improved by emphasising the importance of physical diagnostics teaching and applicating various teaching modes.
Objective: To explore physical diagnostics teaching method and improve teaching quality. Methods: This article summarized some aspects in details about how to improve the teaching quality of physical diagnostics, including emphasizing the importance,combining theory and practice,harmonizing the relationship of teacher,student and patient,enriching teaching methods, reforming examination method and so on. One hundred and sixty college students were investigated by filling out questionnaires for evaluation of teaching effect. Results: The results of questionnaires showed that the physical diagnostics teaching reform had been well accepted by students. Conclusions: The teaching quality could be improved by emphasising the importance of physical diagnostics teaching and applicating various teaching modes.
2011, 36(6): 656-658.
Abstract:
Objective: To investigate the teacher-oriented anxiety among college students. Methods: A total of 1 079 college students and 100 teachers selected from four universities were inquired by Self-Rating Anxiety Scale(SAS) and a self-designed questionnaire. Results: The anxiety score of the college students was higher than that of normal people(P < 0.05). The general anxiety rate of the students was 12.42%. One hundred and thirty-four students demonstrated anxiety,126 of whom were in a mild state and 8 were in a moderate to severe state. About students and teachers considered that the incidence of students' anxiety was closely correlated with teachers' improper teaching concept and performance as well as their lack of mental health knowledge. Conclusions: The prevalence of anxiety is rather high among college students,which is mainly induced by teachers' improper teaching concept and behavior as well as their lack of mental health knowledge. It is suggested that more attention should be paid to the teacher-oriented anxiety in college students'.
Objective: To investigate the teacher-oriented anxiety among college students. Methods: A total of 1 079 college students and 100 teachers selected from four universities were inquired by Self-Rating Anxiety Scale(SAS) and a self-designed questionnaire. Results: The anxiety score of the college students was higher than that of normal people(P < 0.05). The general anxiety rate of the students was 12.42%. One hundred and thirty-four students demonstrated anxiety,126 of whom were in a mild state and 8 were in a moderate to severe state. About students and teachers considered that the incidence of students' anxiety was closely correlated with teachers' improper teaching concept and performance as well as their lack of mental health knowledge. Conclusions: The prevalence of anxiety is rather high among college students,which is mainly induced by teachers' improper teaching concept and behavior as well as their lack of mental health knowledge. It is suggested that more attention should be paid to the teacher-oriented anxiety in college students'.
2011, 36(6): 659-661.
Abstract:
Objective: To observe the effects of evidence-based nursing in the emergency gastric lavage. Methods: One hundred and twenty-four patients who need emergency gastric lavage were collected and randomly divided into observation group and control group. Sixty-two patients were divided into each group. Evidence-based nursing gastric lavage was used in observation group. Traditional gastric lavage was used in control group. The time of gastric lavage,the occurrences of untoward effects and complication,the satisfaction of nursing, the score of SAS and SDS were observed. The differences of these two groups were observed. Results: The time of first liquid extraction and total gastric lavage time were significantly shorter in observation group than that in control(P < 0.01). The occurrences of untoward effects and complication were significantly lower in observation group than that in control (P < 0.01). The satisfaction of nursing, the score of SAS and SDS were significantly better in observation group than that in control (P < 0.01). Conclusions: Evidence-based nursing in the emergency gastric lavage have a shorten time of gastric lavage, low occurrence of untoward effects and complication, high satisfaction of nursing, reduce the anxiety and depressed of patients.
Objective: To observe the effects of evidence-based nursing in the emergency gastric lavage. Methods: One hundred and twenty-four patients who need emergency gastric lavage were collected and randomly divided into observation group and control group. Sixty-two patients were divided into each group. Evidence-based nursing gastric lavage was used in observation group. Traditional gastric lavage was used in control group. The time of gastric lavage,the occurrences of untoward effects and complication,the satisfaction of nursing, the score of SAS and SDS were observed. The differences of these two groups were observed. Results: The time of first liquid extraction and total gastric lavage time were significantly shorter in observation group than that in control(P < 0.01). The occurrences of untoward effects and complication were significantly lower in observation group than that in control (P < 0.01). The satisfaction of nursing, the score of SAS and SDS were significantly better in observation group than that in control (P < 0.01). Conclusions: Evidence-based nursing in the emergency gastric lavage have a shorten time of gastric lavage, low occurrence of untoward effects and complication, high satisfaction of nursing, reduce the anxiety and depressed of patients.
Application of fast track surgery theory in perioperative nursing care for patients with lung cancer
2011, 36(6): 663-665.
Abstract:
Objective: To observe the effect of fast track surgery(FTS) theory in perioperative nursing care for patients with lung cancer. Methods: A total of 60 cases of lung cancer were randomized divided into two groups. The control group received conventional nursing care and the experimental group adopted fast track surgery theory in perioperative nursing care. The incidence of post-operation pain,atelectasis,pleural effusion,lung infection,and the time of post-operative hospital stay and the total cost during hospitalization were compared between the two groups. Results: The VAS score of post operation pain at 24 hours,the incidence of atelectasis,the length of hospital stay after operation and the total cost decreased significantly in the experimental group when compared with that in the control group(P < 0.05-P < 0.01). There was no significant difference in the incidence of lung infection or pleural effusion between the two groups(P > 0.05). Conclusions: Application of FTS theory in perioperative nursing care could apparently accelerate the recovery of patients receiving lung cancer surgery,decrease the complication,shorten the time of hospital stay and cut down the total cost.
Objective: To observe the effect of fast track surgery(FTS) theory in perioperative nursing care for patients with lung cancer. Methods: A total of 60 cases of lung cancer were randomized divided into two groups. The control group received conventional nursing care and the experimental group adopted fast track surgery theory in perioperative nursing care. The incidence of post-operation pain,atelectasis,pleural effusion,lung infection,and the time of post-operative hospital stay and the total cost during hospitalization were compared between the two groups. Results: The VAS score of post operation pain at 24 hours,the incidence of atelectasis,the length of hospital stay after operation and the total cost decreased significantly in the experimental group when compared with that in the control group(P < 0.05-P < 0.01). There was no significant difference in the incidence of lung infection or pleural effusion between the two groups(P > 0.05). Conclusions: Application of FTS theory in perioperative nursing care could apparently accelerate the recovery of patients receiving lung cancer surgery,decrease the complication,shorten the time of hospital stay and cut down the total cost.
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