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2011 Vol. 36, No. 7
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2011, 36(7): 669-672.
Abstract:
Objective: To detect the Nucleostemin (NS) gene expression in some tumor cells, and study the effect of NS in cell proliferation. Methods: Cervical cancer cells, breast cancer cells, ductal carcinoma, hepatoma cells (SMCC7721), hepatoma cells (HpeG2) and normal liver cells were cultured in vitro. Cells in logarithmic growth phase were collected and total RNA was extracted from 6 kinds of cultured tumor lines. The NS differential expression level was measured by RT-PCR and western blotting. Results: All tumor cells in a high level of NS gene expression,especially SKRB-3 breast cancer cells,breast ductal carcinoma T47-D cells,hepatoma SMCC-7721 and HepG2 cells had the highest expression of NS gene, and no NS expression was detected in normal liver cells. Conclusions: NS is highly expressed among all kind of tumor cells is universality,and no expression in terminally differentiated normal liver cells. NS genes could involve in tumor cell proliferation regulation,which provided new method and target for cancer gene therapy and gene diagnosis.
Objective: To detect the Nucleostemin (NS) gene expression in some tumor cells, and study the effect of NS in cell proliferation. Methods: Cervical cancer cells, breast cancer cells, ductal carcinoma, hepatoma cells (SMCC7721), hepatoma cells (HpeG2) and normal liver cells were cultured in vitro. Cells in logarithmic growth phase were collected and total RNA was extracted from 6 kinds of cultured tumor lines. The NS differential expression level was measured by RT-PCR and western blotting. Results: All tumor cells in a high level of NS gene expression,especially SKRB-3 breast cancer cells,breast ductal carcinoma T47-D cells,hepatoma SMCC-7721 and HepG2 cells had the highest expression of NS gene, and no NS expression was detected in normal liver cells. Conclusions: NS is highly expressed among all kind of tumor cells is universality,and no expression in terminally differentiated normal liver cells. NS genes could involve in tumor cell proliferation regulation,which provided new method and target for cancer gene therapy and gene diagnosis.
2011, 36(7): 673-676.
Abstract:
Objective: To observe the effects of ginkgo blades extraction(EGb) combined with edaravone(ED) on expressions of NO and NOS in Qi deficient and blood stasis type of rat brain tissue with cerebral ischemia reperfusion injury. Methods: Rats model with Qi deficient and blood stasis were reproduced by hunger,fatigue and high-fat diet. Then the suture method was used to block up the middle cerebral artery for 2 hours,followed by 72 hours' reperfusion therapy. The expressions of NO and NOS in brain tissue were evaluated on the rats model treated with EGb,ED and EGb combined with ED respectively. Results: Compared with model group,EGb and ED all decreased the levels of NO/iNOS and TNOS in Qi deficient and blood stasis type of rat brain tissues with cerebral ischemia reperfusion injury,and the injuries to neurons(P < 0.01). The effect was significant especially in group of EGb combinied with ED(P < 0.01). Conclusions: EGb associated ED can obviously inhibit the levels of NO in in Qi deficient and blood stasis type of rat brain tissues with cerebral ischemia reperfusion injury,and the mechanism of it may be through reducing the expression of iNOS and TNOS proteins in brain tissue to remove the free radicals,reduce nerve cell damages,and protect brain tissue.
Objective: To observe the effects of ginkgo blades extraction(EGb) combined with edaravone(ED) on expressions of NO and NOS in Qi deficient and blood stasis type of rat brain tissue with cerebral ischemia reperfusion injury. Methods: Rats model with Qi deficient and blood stasis were reproduced by hunger,fatigue and high-fat diet. Then the suture method was used to block up the middle cerebral artery for 2 hours,followed by 72 hours' reperfusion therapy. The expressions of NO and NOS in brain tissue were evaluated on the rats model treated with EGb,ED and EGb combined with ED respectively. Results: Compared with model group,EGb and ED all decreased the levels of NO/iNOS and TNOS in Qi deficient and blood stasis type of rat brain tissues with cerebral ischemia reperfusion injury,and the injuries to neurons(P < 0.01). The effect was significant especially in group of EGb combinied with ED(P < 0.01). Conclusions: EGb associated ED can obviously inhibit the levels of NO in in Qi deficient and blood stasis type of rat brain tissues with cerebral ischemia reperfusion injury,and the mechanism of it may be through reducing the expression of iNOS and TNOS proteins in brain tissue to remove the free radicals,reduce nerve cell damages,and protect brain tissue.
2011, 36(7): 676-679.
Abstract:
Objective: To investigate whether the cardioprotection of ethanol postconditioning can be attenuated by inhibition of phosphatidylinositol-3 kinase(PI3K) pathway in isolated rat hearts subjected to ischemia and reperfusion. Methods: Hearts isolated from male Sprague-Dawley rats were perfused on a langendorff apparatus and subjected to 30 minutes of regional ischemia(occlusion of left anterior descending artery) followed by 120 minutes of reperfusion. The ventricular hemodynamic parameters and lactate dehydrogenase (LDH) release during reperfusion were measured. Results: In contrast to ischemia and reperfusion, ethanol postconditioning improved the recovery of left ventricular developed pressure,maximal rise/fall rate of left ventricular pressure,rate pressure product and reduced LDH release during reperfusion(P < 0.01). Administration of PI3K inhibitor wortmannin attenuated the effect of ethanol postconditioning,the recovery of hemodynamic parameters were inhibited(P < 0.05-P < 0.01),LDH release was increased(P < 0.01). Conclusions: These findings indicate that inhibition of PI3K pathway can attenuate the cardioprotection of ethanol postconditioning.
Objective: To investigate whether the cardioprotection of ethanol postconditioning can be attenuated by inhibition of phosphatidylinositol-3 kinase(PI3K) pathway in isolated rat hearts subjected to ischemia and reperfusion. Methods: Hearts isolated from male Sprague-Dawley rats were perfused on a langendorff apparatus and subjected to 30 minutes of regional ischemia(occlusion of left anterior descending artery) followed by 120 minutes of reperfusion. The ventricular hemodynamic parameters and lactate dehydrogenase (LDH) release during reperfusion were measured. Results: In contrast to ischemia and reperfusion, ethanol postconditioning improved the recovery of left ventricular developed pressure,maximal rise/fall rate of left ventricular pressure,rate pressure product and reduced LDH release during reperfusion(P < 0.01). Administration of PI3K inhibitor wortmannin attenuated the effect of ethanol postconditioning,the recovery of hemodynamic parameters were inhibited(P < 0.05-P < 0.01),LDH release was increased(P < 0.01). Conclusions: These findings indicate that inhibition of PI3K pathway can attenuate the cardioprotection of ethanol postconditioning.
2011, 36(7): 680-683.
Abstract:
Objective: To investigate the expression of Apelin in kidney tissues of adriamycin-induced nephrotic rats and the relationship between Apelin and urine protein excretions,serum cholesterin in the development of nephrosis. Methods: Forty Wistar rats were divided into nephrosis group and control group. Rat model of Nephrosis was induced by single intravenous injection of adriamycin (ADR) 5 mg/kg,while control rat was intravenously injected with normal saline. The levels of urine protein excretions and serum cholesterin in 24 h were measured by chemical chromatometry. The changes of apelin expression in kidney were detected by method of HE,and its correlations to urine protein and serum cholesterin were analyzed. Results: Compared with control group,the levels of 24 h urine protein excretions and serum cholesterin were significantly increased in nephrosis group (P < 0.05-P < 0.01). There was positive correlation between the expression of apelin protein in kidney tissues and the level of urine protein excretions or serum cholesterin(P < 0.05). Conclusions: The Apelin expression is located in glomerular capillary loops. There is the levels of expression of urine protein excretions and serum cholesterin are closely related with the apelin expression in kidney is correlated with proteinura and hyperlipidemia in the development of nephrosis.
Objective: To investigate the expression of Apelin in kidney tissues of adriamycin-induced nephrotic rats and the relationship between Apelin and urine protein excretions,serum cholesterin in the development of nephrosis. Methods: Forty Wistar rats were divided into nephrosis group and control group. Rat model of Nephrosis was induced by single intravenous injection of adriamycin (ADR) 5 mg/kg,while control rat was intravenously injected with normal saline. The levels of urine protein excretions and serum cholesterin in 24 h were measured by chemical chromatometry. The changes of apelin expression in kidney were detected by method of HE,and its correlations to urine protein and serum cholesterin were analyzed. Results: Compared with control group,the levels of 24 h urine protein excretions and serum cholesterin were significantly increased in nephrosis group (P < 0.05-P < 0.01). There was positive correlation between the expression of apelin protein in kidney tissues and the level of urine protein excretions or serum cholesterin(P < 0.05). Conclusions: The Apelin expression is located in glomerular capillary loops. There is the levels of expression of urine protein excretions and serum cholesterin are closely related with the apelin expression in kidney is correlated with proteinura and hyperlipidemia in the development of nephrosis.
2011, 36(7): 684-686.
Abstract:
Objective: To construct and identify serial human BRD8 luciferase reporter genes with the identical 3'-end but gradually truncated 5'-end. Methods: The BRD8 promotor fragment from human genome was amplified by polymerase chain reaction(PCR) and inserted into the luciferase reporter gene vector pGL3-Basic. A series of BRD8 promotor fragments with the identical 3'-end but gradually truncated 5'-end were produced by PCR using the above constructed BRD8 reporter gene vector as template and inserted into pGL3-Basic vector,respectively. The series of BRD8 reporter genes were identified by restriction enzyme digestion and sequencing. Results: The restriction enzyme digestion and DNA sequencing results showed that the sequences and orientation of the serial BRD8 reporter genes were correct. Conclusions: The serial human BRD8 reporter genes had been successfully constructed. These provide an experimental base for further research on the regulation of BRD8 gene transcription by some specific transcription factors and/or silencers.
Objective: To construct and identify serial human BRD8 luciferase reporter genes with the identical 3'-end but gradually truncated 5'-end. Methods: The BRD8 promotor fragment from human genome was amplified by polymerase chain reaction(PCR) and inserted into the luciferase reporter gene vector pGL3-Basic. A series of BRD8 promotor fragments with the identical 3'-end but gradually truncated 5'-end were produced by PCR using the above constructed BRD8 reporter gene vector as template and inserted into pGL3-Basic vector,respectively. The series of BRD8 reporter genes were identified by restriction enzyme digestion and sequencing. Results: The restriction enzyme digestion and DNA sequencing results showed that the sequences and orientation of the serial BRD8 reporter genes were correct. Conclusions: The serial human BRD8 reporter genes had been successfully constructed. These provide an experimental base for further research on the regulation of BRD8 gene transcription by some specific transcription factors and/or silencers.
2011, 36(7): 687-689,692.
Abstract:
Objective: To provide anatomiatic information for operation of pterygopalatine fossa by observing the anatomical structures of pterygopalatine fossa and measuring the anatomical relations of branches of its maxillary artery and nerve. Methods: Eighty pieces(40 examples) of dry skull and 40 pieces(20 examples) of corpses fixed with formalin were desected. The intersection point of the second permanent maxillary molar and alveolar ridge was used as control point. The lengths of the midate point of circular hole,the midate point of sphenopalatine foramen leading edge,the point of infraorbital groove start,gilled tube and canalis pterygopalatinusp from control point were measured. The length of maxillary artery and nerve branches from control point were also measured and observed. Results: Pterygopalatine fossa was a irregular inverted cone. The average lengths of the midate point of circular hole, the midate point of sphenopalatine foramen leading edge,the point of infraorbital groove start,gilled tube and canalis pterygopalatinusp from control point were (48.47 ±2.63),(41.07 ±3.25),(39.91 ±1.84),(47.54 ±2.66),(44.48 ±1.92) and (30.70 ±1.45) mm,respectively. The average lengths of maxillary nerve trunk,superior alveolar nerve,nervi pterygopalatini nerve and sphenopalatine nerve from control point were(50.34 ±3.46),(36.39 ±2.65),(34.72 ±2.77) and(37.43 ±3.12) mm respectively. The average lengths of maxillary artery trunk,posterior superior alveolar artery,infraorbital art,escending palatine artery,and sphenopalatine artery from control point were(32.91 ±2.74),(26.36 ±1.67),(30.96 ±2.02),(31.24 ±2.49) and(30.50 ±2.38) mm,respectively. Conclusions: The intersection point of the second permanent maxillary molar and alveolar ridge was a important mark for looking for the anatomy of pterygopalatine fossa,which could be divided into the nervous layer and vascular layer.
Objective: To provide anatomiatic information for operation of pterygopalatine fossa by observing the anatomical structures of pterygopalatine fossa and measuring the anatomical relations of branches of its maxillary artery and nerve. Methods: Eighty pieces(40 examples) of dry skull and 40 pieces(20 examples) of corpses fixed with formalin were desected. The intersection point of the second permanent maxillary molar and alveolar ridge was used as control point. The lengths of the midate point of circular hole,the midate point of sphenopalatine foramen leading edge,the point of infraorbital groove start,gilled tube and canalis pterygopalatinusp from control point were measured. The length of maxillary artery and nerve branches from control point were also measured and observed. Results: Pterygopalatine fossa was a irregular inverted cone. The average lengths of the midate point of circular hole, the midate point of sphenopalatine foramen leading edge,the point of infraorbital groove start,gilled tube and canalis pterygopalatinusp from control point were (48.47 ±2.63),(41.07 ±3.25),(39.91 ±1.84),(47.54 ±2.66),(44.48 ±1.92) and (30.70 ±1.45) mm,respectively. The average lengths of maxillary nerve trunk,superior alveolar nerve,nervi pterygopalatini nerve and sphenopalatine nerve from control point were(50.34 ±3.46),(36.39 ±2.65),(34.72 ±2.77) and(37.43 ±3.12) mm respectively. The average lengths of maxillary artery trunk,posterior superior alveolar artery,infraorbital art,escending palatine artery,and sphenopalatine artery from control point were(32.91 ±2.74),(26.36 ±1.67),(30.96 ±2.02),(31.24 ±2.49) and(30.50 ±2.38) mm,respectively. Conclusions: The intersection point of the second permanent maxillary molar and alveolar ridge was a important mark for looking for the anatomy of pterygopalatine fossa,which could be divided into the nervous layer and vascular layer.
2011, 36(7): 690-692.
Abstract:
Objective: To study the drug resistance mechanism of Staphylococcus aureus (aureaus) to vancomycin. Methods: Vancomycin was applied in vitro to induce vancomycin resistant heterogeneity aureaus strains; then nuc gene(aureaus specificity gene) and vanA gene(vancomycin resistance gene) were detected by PCR. Results: Vancomycin resistant aureaus contained nuc gene,but no vanA gene. Conclusions: Vancomycin resistant aureaus contains no common vancomycin resistant gene,cell wall thickening is maybe one of the main mechanisms of aureaus to vancomycin resistance.
Objective: To study the drug resistance mechanism of Staphylococcus aureus (aureaus) to vancomycin. Methods: Vancomycin was applied in vitro to induce vancomycin resistant heterogeneity aureaus strains; then nuc gene(aureaus specificity gene) and vanA gene(vancomycin resistance gene) were detected by PCR. Results: Vancomycin resistant aureaus contained nuc gene,but no vanA gene. Conclusions: Vancomycin resistant aureaus contains no common vancomycin resistant gene,cell wall thickening is maybe one of the main mechanisms of aureaus to vancomycin resistance.
2011, 36(7): 693-695.
Abstract:
Objective: To investigate the curative effect of sigmoid neobladder after radical cystectomy in 15 patients with invasive bladder cancer. Methods: Sigmoid neobladder was conducted after radical cystectomy in 15 males with bladder cancer. The curative effect and technical points were analyzed. Results: Fifteen cases were followed up for 6 to 72 months. Bilateral and unilateral hydronephrosis was found in 5 cases and in 1 case,respectively. The volume of urodochium was 210 to 456 ml,and the static pressure in neobladder was 18.6 to 31.8 cmH2O. Vesical micturition pressure was 36.21 to 71.56 cmH2O. Qmax was between 10.22 to 12.26 ml/s. The residual urine volume was 33 to 58 ml. Daytime incontinence was found in 1 case in the first year after operation. Nocturnal urinary incontinence was found in 11 cases. Conclusions: The sigmoid neobladder had several advantages including an adequate reservoir capacity,recovery of automatic micturition,good renal function,no acid-base and electrolyte imbalance,and the continence effect was good at daytime,but not good at night. It could be a good choice a better operation in replacing bladder.
Objective: To investigate the curative effect of sigmoid neobladder after radical cystectomy in 15 patients with invasive bladder cancer. Methods: Sigmoid neobladder was conducted after radical cystectomy in 15 males with bladder cancer. The curative effect and technical points were analyzed. Results: Fifteen cases were followed up for 6 to 72 months. Bilateral and unilateral hydronephrosis was found in 5 cases and in 1 case,respectively. The volume of urodochium was 210 to 456 ml,and the static pressure in neobladder was 18.6 to 31.8 cmH2O. Vesical micturition pressure was 36.21 to 71.56 cmH2O. Qmax was between 10.22 to 12.26 ml/s. The residual urine volume was 33 to 58 ml. Daytime incontinence was found in 1 case in the first year after operation. Nocturnal urinary incontinence was found in 11 cases. Conclusions: The sigmoid neobladder had several advantages including an adequate reservoir capacity,recovery of automatic micturition,good renal function,no acid-base and electrolyte imbalance,and the continence effect was good at daytime,but not good at night. It could be a good choice a better operation in replacing bladder.
2011, 36(7): 695-697.
Abstract:
Objective: To study the etiology and its influence on the mother and infant of severe pregnancy thrombocytopenia. Methods: The clinical data of 37 cases of severe pregnancy thrombocytopenia were analyzed retrospectively. The cases were divided into two groups according to the causes of the disease. The cases with pregnancy-associated thrombocytopenia(PAT) were enrolled in group Ⅰ and the cases with idiopathic thrombocytopenic purpura(ITP),aplastic anemia,HELLP syndrome and myelodysplasia(MDS-RA) in groupⅡ. The outcome was compared between the two groups. Results: Twenty-three cases(62.3%) of severe thrombocytopenia during pregnancy were caused by PAT,and 9 cases(24.32%) were caused by ITP. The incidence of postpartum hemorrhage in groupⅡ was markedly higher than that in group Ⅰ(P < 0.05). The neonate's average birth weight in group Ⅰwas higher than that in group Ⅱ,and the average gestational age of groupⅠwas senior to that of group Ⅱ(P < 0.05-P < 0.01). The platelet counts in groupⅠ recovered more quickly than that in group Ⅱ 10 days after the operation(P < 0.01). Conclusions: The major causes of severe thrombocytopenia during pregnancy are PAT and ITP; however,the patients suffering from PAT have a better outcome.
Objective: To study the etiology and its influence on the mother and infant of severe pregnancy thrombocytopenia. Methods: The clinical data of 37 cases of severe pregnancy thrombocytopenia were analyzed retrospectively. The cases were divided into two groups according to the causes of the disease. The cases with pregnancy-associated thrombocytopenia(PAT) were enrolled in group Ⅰ and the cases with idiopathic thrombocytopenic purpura(ITP),aplastic anemia,HELLP syndrome and myelodysplasia(MDS-RA) in groupⅡ. The outcome was compared between the two groups. Results: Twenty-three cases(62.3%) of severe thrombocytopenia during pregnancy were caused by PAT,and 9 cases(24.32%) were caused by ITP. The incidence of postpartum hemorrhage in groupⅡ was markedly higher than that in group Ⅰ(P < 0.05). The neonate's average birth weight in group Ⅰwas higher than that in group Ⅱ,and the average gestational age of groupⅠwas senior to that of group Ⅱ(P < 0.05-P < 0.01). The platelet counts in groupⅠ recovered more quickly than that in group Ⅱ 10 days after the operation(P < 0.01). Conclusions: The major causes of severe thrombocytopenia during pregnancy are PAT and ITP; however,the patients suffering from PAT have a better outcome.
2011, 36(7): 698-700.
Abstract:
Objective: To study the current status of anti-coagulation treatment by guideline and the best initial warfarin dose in patients with nonvalvular atrial fibrillation (NVAF) in primary hospital. Methods: Two hundred and fifty-six patients without contraindication to anti-coagulation therapy were enrolled into this study. The status of using warfarin were registered and analyzed. Patients with NVAF who used warfain to anti-coagulation treatment were randomly assigned to two groups according to different initial dose,3.125 mg and 5 mg. The dose of warfarin was adjusted according to international normalized ratio(INR),until INR was stabilized between 2.0 and 3.0 for at least 2 months at the same dose of warfarin. Results: Among two hundred and fifty-six cases with NVAF, only 47 cases(18.4%) were given anti-coagulation treatment by guideline. Of the total 164 cases(64.1%) of high risk group,29 cases (17.7%) were given warfarin. Among 164 patients of high risk group,the ratio of warfarin used in paroxysmal atrial fibrillation was significant lower than persistent atrial fibrillation and long standing atrial fibrillation (P < 0.05). Treatment decision-making of physicians and patients factors were associated with low rates of warfarin used. The mean time achieving a stabilized target INR in two groups was significant(P > 0.05). The incidence of exorbitant INR was shorter than that in the 5 mg group(P < 0.05). There was no significant difference in thromboembolisms and important hemorrhage complications in two groups(P > 0.05). Conclusions: Most of the patients with NVAF did not receive appropriate antithrombotic therapy in primary hospital. An initial warfarin dose of 3.125 mg treatment may reach the stabilized INR range quickly,safely and efficiently without increasing the bleeding complications.
Objective: To study the current status of anti-coagulation treatment by guideline and the best initial warfarin dose in patients with nonvalvular atrial fibrillation (NVAF) in primary hospital. Methods: Two hundred and fifty-six patients without contraindication to anti-coagulation therapy were enrolled into this study. The status of using warfarin were registered and analyzed. Patients with NVAF who used warfain to anti-coagulation treatment were randomly assigned to two groups according to different initial dose,3.125 mg and 5 mg. The dose of warfarin was adjusted according to international normalized ratio(INR),until INR was stabilized between 2.0 and 3.0 for at least 2 months at the same dose of warfarin. Results: Among two hundred and fifty-six cases with NVAF, only 47 cases(18.4%) were given anti-coagulation treatment by guideline. Of the total 164 cases(64.1%) of high risk group,29 cases (17.7%) were given warfarin. Among 164 patients of high risk group,the ratio of warfarin used in paroxysmal atrial fibrillation was significant lower than persistent atrial fibrillation and long standing atrial fibrillation (P < 0.05). Treatment decision-making of physicians and patients factors were associated with low rates of warfarin used. The mean time achieving a stabilized target INR in two groups was significant(P > 0.05). The incidence of exorbitant INR was shorter than that in the 5 mg group(P < 0.05). There was no significant difference in thromboembolisms and important hemorrhage complications in two groups(P > 0.05). Conclusions: Most of the patients with NVAF did not receive appropriate antithrombotic therapy in primary hospital. An initial warfarin dose of 3.125 mg treatment may reach the stabilized INR range quickly,safely and efficiently without increasing the bleeding complications.
2011, 36(7): 701-704.
Abstract:
Objective: To compare the anesthesia effects and security of different dose of fentanyl injection combined sevflurance inhalational anesthesia by larygeal mask airway(LMA) in the ureteroscope pneumatic lithotripsy(URSL). Methods: Eighty patients, classified ASA Ⅰ-Ⅱ,scheduled for the selective surgery of URSL,were randomly divided into four groups with 20 cases each. Group A was given total sevoflurane inhalational anesthesia, Group B、C、D received intravenous fentanyl 1,2 and 4 μg/kg respectively, 2 minutes before sevflurance inhalational anesthesia induction was implemented. The vital signs such as heart rate(HR)、mean arterial pressure(MAP),arterial oxygen saturation(SpO2) and end-tidal pressure of carbon dioxide(PETCO2) were monitored during anesthesia, and induction time, awakening time, intraoperative medication, body motion were recorded. Meanwhile, the complications such as respiratory depression, postoperative dizziness, nausea and vomiting were observed. Results: Four groups underwent the operation smoothly,and awareness with recall during general anesthesia didn't occur. After induction,MAP of four groups declined (P < 0.05-P < 0.01),MAP of Group D dropped more than that of A,B and C(P <0.05-P <0.01). HR of Group D was decreased temporarily (P < 0.05). There was no statistically significant difference in the incidence of respiratory depression between Group A,B,C and D(P > 0.05). SpO2 after induction was decreased slightly in Group D(P < 0.01),while PETCO2 was increased(P < 0.05). The induction time in Group A was longer than C and D(P < 0.05-P < 0.01),and the awakening time was not different in the four groups(P > 0.05). The dose of sevoflurane in Group C and D was lower than in A(P < 0.01),the incidence of postoperative nausea and vomiting in Group A was higher than B,C and D(P < 0.05). When the LMA was inserted,there was body motion happened in A and B. Conclusions: The application of fentanyl injection combined sevoflurane inhalational anesthesia by LMA in the URSL is effective and safe. Fentanyl wes given 2 minutes before sevflurance inhalational anesthesia induction,which can shorten the induct time,lower the dose and side effects of sevflurance. When the dose of fentanyl is or over 4 μg/kg,the influence of respiration and circulation will happen.
Objective: To compare the anesthesia effects and security of different dose of fentanyl injection combined sevflurance inhalational anesthesia by larygeal mask airway(LMA) in the ureteroscope pneumatic lithotripsy(URSL). Methods: Eighty patients, classified ASA Ⅰ-Ⅱ,scheduled for the selective surgery of URSL,were randomly divided into four groups with 20 cases each. Group A was given total sevoflurane inhalational anesthesia, Group B、C、D received intravenous fentanyl 1,2 and 4 μg/kg respectively, 2 minutes before sevflurance inhalational anesthesia induction was implemented. The vital signs such as heart rate(HR)、mean arterial pressure(MAP),arterial oxygen saturation(SpO2) and end-tidal pressure of carbon dioxide(PETCO2) were monitored during anesthesia, and induction time, awakening time, intraoperative medication, body motion were recorded. Meanwhile, the complications such as respiratory depression, postoperative dizziness, nausea and vomiting were observed. Results: Four groups underwent the operation smoothly,and awareness with recall during general anesthesia didn't occur. After induction,MAP of four groups declined (P < 0.05-P < 0.01),MAP of Group D dropped more than that of A,B and C(P <0.05-P <0.01). HR of Group D was decreased temporarily (P < 0.05). There was no statistically significant difference in the incidence of respiratory depression between Group A,B,C and D(P > 0.05). SpO2 after induction was decreased slightly in Group D(P < 0.01),while PETCO2 was increased(P < 0.05). The induction time in Group A was longer than C and D(P < 0.05-P < 0.01),and the awakening time was not different in the four groups(P > 0.05). The dose of sevoflurane in Group C and D was lower than in A(P < 0.01),the incidence of postoperative nausea and vomiting in Group A was higher than B,C and D(P < 0.05). When the LMA was inserted,there was body motion happened in A and B. Conclusions: The application of fentanyl injection combined sevoflurane inhalational anesthesia by LMA in the URSL is effective and safe. Fentanyl wes given 2 minutes before sevflurance inhalational anesthesia induction,which can shorten the induct time,lower the dose and side effects of sevflurance. When the dose of fentanyl is or over 4 μg/kg,the influence of respiration and circulation will happen.
2011, 36(7): 704-706.
Abstract:
Objective: To evaluate the efficacy of oxcarbazepine in treatment of migraine. Methods: A randomized,double-blind and placebo-controlled trial was done in 120 cases of patients with migraine,including 54 patients accepted placebos as control group and 66 patients accepted oxcarbazepines as treatment group. Placepos and oxcarbazepines were used in the two groups for 8 weeks. The daily dose for the patients is 900 mg. The intensity of headache during the treatment was recorded by mothed of numeric rating scale(NRS:0-10 scale). The duration of each migraine attack(hours) and migrainer frequency(time/month) were recorded in 8 weeks. Results: All patients were observed for 8 consecutive weeks. The headache intensity, the duration of each migraine attack and frequency of headache in the treatment group were significantly decreased compared with that in the control group (P < 0.01). Conclusions: Oxcarbazepine is effective for prevening and treating of migraine.
Objective: To evaluate the efficacy of oxcarbazepine in treatment of migraine. Methods: A randomized,double-blind and placebo-controlled trial was done in 120 cases of patients with migraine,including 54 patients accepted placebos as control group and 66 patients accepted oxcarbazepines as treatment group. Placepos and oxcarbazepines were used in the two groups for 8 weeks. The daily dose for the patients is 900 mg. The intensity of headache during the treatment was recorded by mothed of numeric rating scale(NRS:0-10 scale). The duration of each migraine attack(hours) and migrainer frequency(time/month) were recorded in 8 weeks. Results: All patients were observed for 8 consecutive weeks. The headache intensity, the duration of each migraine attack and frequency of headache in the treatment group were significantly decreased compared with that in the control group (P < 0.01). Conclusions: Oxcarbazepine is effective for prevening and treating of migraine.
2011, 36(7): 707-708,711.
Abstract:
Objective: To explore the value of a harmonic scalpel in totally extraperitoneal(TEP) inguinal hernioplasty. Methods: One hundred and thirty-seven patients who accepted TEP operation,were prospectively studied from March 2008 to August 2010 in our department:53 patients were accepted surgery with harmonic scalpel,84 patients were accepted standard surgery. The sex,age,follow-up time,type of hernia,surgery time,bleeding,intraoperative complications,transformation of other methods,postoperative drainage volume and complications were recorded. Results: There were no significant differences between harmonic scalpel group and control group at sex,age,follow-up time,type of hernia,surgery time,intraoperative complications,the second-day postoperative drainage volume and late postoperative complications(P > 0.05). The bleeding,the first-day postoperative drainage volume and hematoma,in harmonic scalpel group were significantly lower than those of control group (P < 0.01). Conclusions: The Harmonic Scalpel can be usd to reduce bleeding and complications.
Objective: To explore the value of a harmonic scalpel in totally extraperitoneal(TEP) inguinal hernioplasty. Methods: One hundred and thirty-seven patients who accepted TEP operation,were prospectively studied from March 2008 to August 2010 in our department:53 patients were accepted surgery with harmonic scalpel,84 patients were accepted standard surgery. The sex,age,follow-up time,type of hernia,surgery time,bleeding,intraoperative complications,transformation of other methods,postoperative drainage volume and complications were recorded. Results: There were no significant differences between harmonic scalpel group and control group at sex,age,follow-up time,type of hernia,surgery time,intraoperative complications,the second-day postoperative drainage volume and late postoperative complications(P > 0.05). The bleeding,the first-day postoperative drainage volume and hematoma,in harmonic scalpel group were significantly lower than those of control group (P < 0.01). Conclusions: The Harmonic Scalpel can be usd to reduce bleeding and complications.
2011, 36(7): 709-711.
Abstract:
Objective: To explore the diagnostic value of carcinoembryonic antigen(CEA),CK19,Lunx mRNA in peripheral blood of patients for the micrometastasis in non-small cell lung cancer(NSCLC). Methods: RT-PCR was used to detect the expression of CEA, CK19,and Lunx mRNA in peripheral blood samples from 46 patients with NSCLC and 18 patients with benign pulmonary lesion. Results: The positive rates of Lunx,CEA and CK19 mRNA were 52.2%, 43.5% and 41.3% respectively in peripheral blood of patients with NSCLC. The positive rates of Lunx,CEA and CK19 mRNA in stage Ⅰ were 16.6% (1/6), 16.6% (1/6) and 0% (0/6) respectively, and they had no significant differences with control(P > 0.05). The positive rates of Lunx mRNA in stageⅡ, stage Ⅲ, and stage Ⅳ patients were 44.4% (4/9), 50.0% (7/14), and 70.6% (12/17) respectively. The positive rates of CEA mRNA were 33.3% (3/9), 50.0% (7/14) and 52.9% (9/17) respectively. The positive rates of CK19 mRNA were 22.2% (2/9),42.9% (6/14) and 64.7% (11/17) respectively. The positive rates of Lunx mRNA in stage Ⅱ,CEA mRNA and Lunx mRNA in stage Ⅲ, and Lunx, CEA, CK19 mRNA in stage Ⅳ had significant differences with control (P < 0.05-P < 0.01). Conclusions: The expressions of CEA, CK19 and Lunx mRNA in peripheral blood can be used as diagnostic biomarkers of micrometastasis in patients with NSCLC.
Objective: To explore the diagnostic value of carcinoembryonic antigen(CEA),CK19,Lunx mRNA in peripheral blood of patients for the micrometastasis in non-small cell lung cancer(NSCLC). Methods: RT-PCR was used to detect the expression of CEA, CK19,and Lunx mRNA in peripheral blood samples from 46 patients with NSCLC and 18 patients with benign pulmonary lesion. Results: The positive rates of Lunx,CEA and CK19 mRNA were 52.2%, 43.5% and 41.3% respectively in peripheral blood of patients with NSCLC. The positive rates of Lunx,CEA and CK19 mRNA in stage Ⅰ were 16.6% (1/6), 16.6% (1/6) and 0% (0/6) respectively, and they had no significant differences with control(P > 0.05). The positive rates of Lunx mRNA in stageⅡ, stage Ⅲ, and stage Ⅳ patients were 44.4% (4/9), 50.0% (7/14), and 70.6% (12/17) respectively. The positive rates of CEA mRNA were 33.3% (3/9), 50.0% (7/14) and 52.9% (9/17) respectively. The positive rates of CK19 mRNA were 22.2% (2/9),42.9% (6/14) and 64.7% (11/17) respectively. The positive rates of Lunx mRNA in stage Ⅱ,CEA mRNA and Lunx mRNA in stage Ⅲ, and Lunx, CEA, CK19 mRNA in stage Ⅳ had significant differences with control (P < 0.05-P < 0.01). Conclusions: The expressions of CEA, CK19 and Lunx mRNA in peripheral blood can be used as diagnostic biomarkers of micrometastasis in patients with NSCLC.
2011, 36(7): 712-713,716.
Abstract:
Objective: To study the characteristics of the delivery progress,methods of delivery and perinatal prognosis in cases with fetal persistent occiput-transverse position(POTP) and persistent occiput-posterior position(POPP). Methods: The clinical data of one hundred and twenty-two cases of POTP and POPP were analyzed retrospectively,and one hundred and twenty-one cases of occiput anterior position acted as control. Results: The incidence of fetal macrosoia and uterine atony in the abnormal fetal occipital position group was significantly higher than that in the control(P < 0.05-P < 0.01). And their first labor stage,second labor stage and total labor stage were obviously prolonged compared with the control(P < 0.01). The incidence of fetal hypxia and neonatal asphyxia was markedly higher in the abnormal occiput group than in the control(P < 0.01). Conclusions: The POTP and POPP are the major causes of dystocia. Unsuitable management may increase the operative delivery rate and lead to poor perinatal prognosis.
Objective: To study the characteristics of the delivery progress,methods of delivery and perinatal prognosis in cases with fetal persistent occiput-transverse position(POTP) and persistent occiput-posterior position(POPP). Methods: The clinical data of one hundred and twenty-two cases of POTP and POPP were analyzed retrospectively,and one hundred and twenty-one cases of occiput anterior position acted as control. Results: The incidence of fetal macrosoia and uterine atony in the abnormal fetal occipital position group was significantly higher than that in the control(P < 0.05-P < 0.01). And their first labor stage,second labor stage and total labor stage were obviously prolonged compared with the control(P < 0.01). The incidence of fetal hypxia and neonatal asphyxia was markedly higher in the abnormal occiput group than in the control(P < 0.01). Conclusions: The POTP and POPP are the major causes of dystocia. Unsuitable management may increase the operative delivery rate and lead to poor perinatal prognosis.
2011, 36(7): 714-716.
Abstract:
Objective: To discuss the clinical effects of loop electrosurgical excision procedure(LEEP) treatment of cervical lesions. Methods: A retrospective analysis was conducted on LEEP treatment of 75 cases which were diagnosed as CIN,cervical condyloma and cervicite through colposcopy histopathology. The analysis of bleeding during surgery,complication after surgery,and effect of cervical shapping were done. Results: The levels of blood loss during surgery were as following:< 5 ml in 56 cases; > 5~10 ml in 14 cases; > 10~15 ml in 2 cases; > 15~20 ml in 2 cases; > 20 ml in 1 case. The reactions of surgery included local burning sensation in 15 cases,hypogastrolgia in 2 cases with and no unwell in 58 cases. The postoperative complications happened in 5 cases. Sixty-four patients were satisfied with the outcomes of cervical regeneration,while 8 patients less satisfied and 3 patients not satisfied. Conclusions: The clinical effects of LEEP treatment in cervical lesions can be effectively improved when we understand the operative indications,control the operative range and depth,and orderly review.
Objective: To discuss the clinical effects of loop electrosurgical excision procedure(LEEP) treatment of cervical lesions. Methods: A retrospective analysis was conducted on LEEP treatment of 75 cases which were diagnosed as CIN,cervical condyloma and cervicite through colposcopy histopathology. The analysis of bleeding during surgery,complication after surgery,and effect of cervical shapping were done. Results: The levels of blood loss during surgery were as following:< 5 ml in 56 cases; > 5~10 ml in 14 cases; > 10~15 ml in 2 cases; > 15~20 ml in 2 cases; > 20 ml in 1 case. The reactions of surgery included local burning sensation in 15 cases,hypogastrolgia in 2 cases with and no unwell in 58 cases. The postoperative complications happened in 5 cases. Sixty-four patients were satisfied with the outcomes of cervical regeneration,while 8 patients less satisfied and 3 patients not satisfied. Conclusions: The clinical effects of LEEP treatment in cervical lesions can be effectively improved when we understand the operative indications,control the operative range and depth,and orderly review.
2011, 36(7): 717-718.
Abstract:
Objective: To observe and compare the influence of cardiovascular response between streamlined liner pharynx airway (SLIPA) and trachea cannula in breast cancer patients. Methods: Eighty patients with mammary cancer of ASAⅠ-Ⅱ grade and no cardiovascular disorders were randomly divided into SLIPA group and trachea cannula group,each group induding 28 cases. Systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) were monitored and recorded when the patients entered into operation room(T0),before laryngeal mask insertion(T1),1 minute after laryngeal mask insertion(T2),3 minute after laryngeal mask insertion(T3),5 minute after laryngeal mask insertion (T4),when start operation (T5),after operation (T6),before laryngeal mask withdrawal(T7),after laryngeal mask withdrawal immediately(T8),and 5 minute after laryngeal mask withdrawal(T9). Results: The results of SBP,DBP and HR in the SLIPA group at timepoints T2,T3,T7,T8 and T9 were significantly better than that in the trachea cannula group(P < 0.05-P < 0.01). Conclusions: SLIPA could be a ideal airway veafication method fou braast cancer patients due to minior interffevences to the cardiovascular response.
Objective: To observe and compare the influence of cardiovascular response between streamlined liner pharynx airway (SLIPA) and trachea cannula in breast cancer patients. Methods: Eighty patients with mammary cancer of ASAⅠ-Ⅱ grade and no cardiovascular disorders were randomly divided into SLIPA group and trachea cannula group,each group induding 28 cases. Systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) were monitored and recorded when the patients entered into operation room(T0),before laryngeal mask insertion(T1),1 minute after laryngeal mask insertion(T2),3 minute after laryngeal mask insertion(T3),5 minute after laryngeal mask insertion (T4),when start operation (T5),after operation (T6),before laryngeal mask withdrawal(T7),after laryngeal mask withdrawal immediately(T8),and 5 minute after laryngeal mask withdrawal(T9). Results: The results of SBP,DBP and HR in the SLIPA group at timepoints T2,T3,T7,T8 and T9 were significantly better than that in the trachea cannula group(P < 0.05-P < 0.01). Conclusions: SLIPA could be a ideal airway veafication method fou braast cancer patients due to minior interffevences to the cardiovascular response.
2011, 36(7): 719-721.
Abstract:
Objective: To investigate the effect of intravenous hydration therapy in prevention of contrast-induced nephropathy(CIN) after percutaneous coronary intervention(PCI). Methods: One hundred and eighty cases of patients were divided into the control group (drinking water) and experimental group (intravenous hydration therapy). The levels of serum creatinine(SCr),urea nitrogen (BUN), serum β2-microglobulin(β2-mG),and urinary β2-mG were compared between the two groups after PCI. Results: The levels of SCr, BUN,β2-mG,and urinary β2-mG were significantly lower in experimental group(n=94) than that in control group(n=86) (P < 0.01); CIN occurred in 3 cases of experimental group,but 10 cases of control group(P < 0.05). Conclusions: Intravenous hydration therapy can prevent the injury of kidney function and reduce the incidence of acute renal failure after PCI.
Objective: To investigate the effect of intravenous hydration therapy in prevention of contrast-induced nephropathy(CIN) after percutaneous coronary intervention(PCI). Methods: One hundred and eighty cases of patients were divided into the control group (drinking water) and experimental group (intravenous hydration therapy). The levels of serum creatinine(SCr),urea nitrogen (BUN), serum β2-microglobulin(β2-mG),and urinary β2-mG were compared between the two groups after PCI. Results: The levels of SCr, BUN,β2-mG,and urinary β2-mG were significantly lower in experimental group(n=94) than that in control group(n=86) (P < 0.01); CIN occurred in 3 cases of experimental group,but 10 cases of control group(P < 0.05). Conclusions: Intravenous hydration therapy can prevent the injury of kidney function and reduce the incidence of acute renal failure after PCI.
2011, 36(7): 722-724.
Abstract:
Objective: To observe the clinical effects and safety of ozagrel in treatment of acute ischemic stroke. Methods: One hundred and sixty-two patients with acute ischemic stroke were randomly divided into control group and treatment group, each 81 patients. The patients in control group were treated with common western medicine,while in treatment group was given ozagrel except the common western medicine. Before and after 14 days' treatment,the neurologic impairment and clinical curative effect in the two groups were evaluated. Results: The therapeutic effect rate in the treatment group was 88.89%,and that in control group was 76.54%, there was significantly statistical difference in the two groups(P < 0.01). Conclusions: Ozagrel is effective and safe in treatment of acute ischemic stroke and worthy of being widely used in clinic.
Objective: To observe the clinical effects and safety of ozagrel in treatment of acute ischemic stroke. Methods: One hundred and sixty-two patients with acute ischemic stroke were randomly divided into control group and treatment group, each 81 patients. The patients in control group were treated with common western medicine,while in treatment group was given ozagrel except the common western medicine. Before and after 14 days' treatment,the neurologic impairment and clinical curative effect in the two groups were evaluated. Results: The therapeutic effect rate in the treatment group was 88.89%,and that in control group was 76.54%, there was significantly statistical difference in the two groups(P < 0.01). Conclusions: Ozagrel is effective and safe in treatment of acute ischemic stroke and worthy of being widely used in clinic.
2011, 36(7): 724-725.
Abstract:
Objective: To investigate the diagnosis and treatment of left colon carcinoma with obstrution in elderly patient. Methods: Thirty-eight cases of colon carcinoma were retrospectively analyzed. Twenty-nine cases received radical resection and one-stage anastomosis,7 cases were undergone Hartmann operation,2 cases received bypass operation. Results: Thirty-seven cases were cured (among them,2 cases with developed anastomosis leakage received second-operation and healed),1 case with developed anastomosis leakage and died. Conclusions: One-stage anastomosisis is safe and feasible for elderly patient who had colon cancer with obstruction, under the condition of strict perioperative treatment and enough lavage.
Objective: To investigate the diagnosis and treatment of left colon carcinoma with obstrution in elderly patient. Methods: Thirty-eight cases of colon carcinoma were retrospectively analyzed. Twenty-nine cases received radical resection and one-stage anastomosis,7 cases were undergone Hartmann operation,2 cases received bypass operation. Results: Thirty-seven cases were cured (among them,2 cases with developed anastomosis leakage received second-operation and healed),1 case with developed anastomosis leakage and died. Conclusions: One-stage anastomosisis is safe and feasible for elderly patient who had colon cancer with obstruction, under the condition of strict perioperative treatment and enough lavage.
2011, 36(7): 726-728.
Abstract:
Objective: To investigate the safety and effect of early feeding and no nasogastric tube decompression in upper gastrointestinal tract perforation repair. Methods: Thirty-one cases of routine nasogastric decompression were selected randomly as control group,and 28 cases of early feeding and no nasogastric tube decompression selected as trial grpup. The recovery time of bowel sounds,rectal discharge,complication rates of nausea,vomiting,and distention were compared between the two groups. Results: The recovery time of bowel sounds and rectal discharge in trial group was much earlier than that in control group(P < 0.01). Cases of vomiting and distention showed no statisticus difference in two groups (P > 0.05). Conclusions: It is safe and benefictial for the patient's quick recovery to apply early feeding without routine nasogastric decompression for upper gastrointestinal perforation repare.
Objective: To investigate the safety and effect of early feeding and no nasogastric tube decompression in upper gastrointestinal tract perforation repair. Methods: Thirty-one cases of routine nasogastric decompression were selected randomly as control group,and 28 cases of early feeding and no nasogastric tube decompression selected as trial grpup. The recovery time of bowel sounds,rectal discharge,complication rates of nausea,vomiting,and distention were compared between the two groups. Results: The recovery time of bowel sounds and rectal discharge in trial group was much earlier than that in control group(P < 0.01). Cases of vomiting and distention showed no statisticus difference in two groups (P > 0.05). Conclusions: It is safe and benefictial for the patient's quick recovery to apply early feeding without routine nasogastric decompression for upper gastrointestinal perforation repare.
2011, 36(7): 728-730.
Abstract:
Objective: To evaluate the safety and efficacy of transurethral plasmakinetic resection of prostate(TUPKRP) for treatment of benign prostatic hyperplasia(BPH). Methods: The 120 cases of BPH were treated by TUPKRP,the cutting method was performed according to the size of gland. The international prostate symptom score(IPSS),quality of life(QOL),maximum flow rate(Qmax), postvoid residual volume(PRV) of preoperation and postoperation were observed and statistically analyzed. Results: All cases were treated successfully. The operative time was 30-200 min,the weight of resected tissue was 10-100 g,the intraoperative blood loss was 30-200ml,the bladder irrigating time after operation was 2-6 d,the duration of catheter was 3-7 d,and the hospital stay after operation was 5-16 d. There was no operative death,no blood transfusion was required,and no perforation of the prostatic capsule, obturator nerve reflex and transurethral resection syndrome (TURS) occurred. All patients were followed up for 3-12 months postoperatively,there were no serious complications. The differences of IPSS, QOL, Qmax and PRV between preoperation and postoperation were statistically significances(P < 0.01). Conclusions: TUPKRP is a safe and effective method for treatment of BPH,it is worth popularizing.
Objective: To evaluate the safety and efficacy of transurethral plasmakinetic resection of prostate(TUPKRP) for treatment of benign prostatic hyperplasia(BPH). Methods: The 120 cases of BPH were treated by TUPKRP,the cutting method was performed according to the size of gland. The international prostate symptom score(IPSS),quality of life(QOL),maximum flow rate(Qmax), postvoid residual volume(PRV) of preoperation and postoperation were observed and statistically analyzed. Results: All cases were treated successfully. The operative time was 30-200 min,the weight of resected tissue was 10-100 g,the intraoperative blood loss was 30-200ml,the bladder irrigating time after operation was 2-6 d,the duration of catheter was 3-7 d,and the hospital stay after operation was 5-16 d. There was no operative death,no blood transfusion was required,and no perforation of the prostatic capsule, obturator nerve reflex and transurethral resection syndrome (TURS) occurred. All patients were followed up for 3-12 months postoperatively,there were no serious complications. The differences of IPSS, QOL, Qmax and PRV between preoperation and postoperation were statistically significances(P < 0.01). Conclusions: TUPKRP is a safe and effective method for treatment of BPH,it is worth popularizing.
2011, 36(7): 731-732,735.
Abstract:
Objective: To explore the prevention about complications of pituitary adenomas microsurgery and improve the surgery skills. Methods: The clinical data of 12 patients whose pituitary adenomas were resected and accompanied with complications were analyzed respectively. Results: Nine cases were accompanied with insipidus after operation,among them,8 cases were accompanied with acute insipidus,and 1 case with delayed insipidus. One case was with cerebral salt wasting syndrome,2 cases with cerebrospinal rhinorrhea,3 cases with hemorrhage,1 case with visual disturbance,1 case with intracranial infection,2 cases with infarction in frontal lobe and hypothalamus,and 1 case was died. Conclusions: Familiarizing the anatomy of spheniodal sinus,improving the microsurgery skills and treating correctly are all important to decrease the postoperative complications.
Objective: To explore the prevention about complications of pituitary adenomas microsurgery and improve the surgery skills. Methods: The clinical data of 12 patients whose pituitary adenomas were resected and accompanied with complications were analyzed respectively. Results: Nine cases were accompanied with insipidus after operation,among them,8 cases were accompanied with acute insipidus,and 1 case with delayed insipidus. One case was with cerebral salt wasting syndrome,2 cases with cerebrospinal rhinorrhea,3 cases with hemorrhage,1 case with visual disturbance,1 case with intracranial infection,2 cases with infarction in frontal lobe and hypothalamus,and 1 case was died. Conclusions: Familiarizing the anatomy of spheniodal sinus,improving the microsurgery skills and treating correctly are all important to decrease the postoperative complications.
2011, 36(7): 733-735.
Abstract:
Objective: To observe the efficacy of irbesartan/hydrochlorothiazide tablets(IHT) and nifedipine controlled-release tablets (NCRT) in moderate to severe essential hypertension. Methods: Patients were randomly divided into A group(IHT 150 mg,per day, n=21),B group(NCRT 30 mg per day,n=25),C group(150 mg per morning,NCRT 30 mg per night,n=32),three groups were all treated for 12 weeks. Results: Blood pressure of three groups all greatly decreased(P < 0.01),the total effective rate in IHT groups was 61.9%; the total effective rate in NCRT groups was 64.0% the total effective rate in IHT + NCRT groups was 93.8%. Conclusions: IHT plus NCRT are more efficiency than IHT or NCRT group in the treatment of moderate to severe hypertension. So it deserve to popularize fore more efficiency and more security.
Objective: To observe the efficacy of irbesartan/hydrochlorothiazide tablets(IHT) and nifedipine controlled-release tablets (NCRT) in moderate to severe essential hypertension. Methods: Patients were randomly divided into A group(IHT 150 mg,per day, n=21),B group(NCRT 30 mg per day,n=25),C group(150 mg per morning,NCRT 30 mg per night,n=32),three groups were all treated for 12 weeks. Results: Blood pressure of three groups all greatly decreased(P < 0.01),the total effective rate in IHT groups was 61.9%; the total effective rate in NCRT groups was 64.0% the total effective rate in IHT + NCRT groups was 93.8%. Conclusions: IHT plus NCRT are more efficiency than IHT or NCRT group in the treatment of moderate to severe hypertension. So it deserve to popularize fore more efficiency and more security.
2011, 36(7): 736-739.
Abstract:
Objective: examing the methods employed in surgical treatment aiming at curing refractory epilepsy by intervening and the effects such methods intend to achieve. Methods: On the basis of the relative data concerning 65 patients with refractory epilepsy collected through the means of electroencephalogram or EEG,video EEG,CT,single photon emission computed tomography or SPECT, magnetic resonance imaging or MRI,and through assessing their cognitive capacity before their treatments,6 methods were employed respectively. These methods are:resecting the affected area,degenerative brain tissues,and anterior temple lobe,removing hippocampus apricot kernel in a selective way, transecting callosotomy, and craniostenosis restitution opration while using the means of multiple subpial transection(hereafter referred to as MST) in actual operation(the method was employed in one case); resecting affected area and denaturation constitution degenerative brain tissues while using the means of MST and heat treatment in operations(the method was employed in 36 cases); making use of the means MST combined with heat treatment while transecting callosotomy in a selective way in operations(the method was employed in 5 cases);; radiate treatment on both hippocampus apricot kernel combined with the means of MST and heat treatment (the method was employed in 1 case); resecting affected area and denaturation constitution, transecting callosotomy in a selective way combined with the means of MST (the method was employed in 4 cases); resecting affected area, denaturation constitution,anterior temple lobe and hippocampus apricot kernel while using MST (the method was employed in 18 cases). Results: After relative treatments patients were followed up with the length of the follow-up ranging from 6 months to 11 years and judged by the Engel standard 26 of them could reach the level of Ⅰ,and 9 of them could reach the level of Ⅱ,all recovering completely; besides,20 of those patients could reach the level of Ⅲ,recovering well,and 6 of those patient who were followed up could reach the level of Ⅳ,which suggests that the ratio for total recovery could reach to 60.00% and the ratio for ideal recovery could amount to 90.77% and all those patients have demonstrated the sigh of getting better in terms of their intelligence. Conclusions: When dealing with refractory epilepsy concerning multiple focus of refractory epilepsy in surgical treatment,ideal and effective results could realized by employing appropriate but different surgical methods based on the different areas in epilepsy electroencephalogram.
Objective: examing the methods employed in surgical treatment aiming at curing refractory epilepsy by intervening and the effects such methods intend to achieve. Methods: On the basis of the relative data concerning 65 patients with refractory epilepsy collected through the means of electroencephalogram or EEG,video EEG,CT,single photon emission computed tomography or SPECT, magnetic resonance imaging or MRI,and through assessing their cognitive capacity before their treatments,6 methods were employed respectively. These methods are:resecting the affected area,degenerative brain tissues,and anterior temple lobe,removing hippocampus apricot kernel in a selective way, transecting callosotomy, and craniostenosis restitution opration while using the means of multiple subpial transection(hereafter referred to as MST) in actual operation(the method was employed in one case); resecting affected area and denaturation constitution degenerative brain tissues while using the means of MST and heat treatment in operations(the method was employed in 36 cases); making use of the means MST combined with heat treatment while transecting callosotomy in a selective way in operations(the method was employed in 5 cases);; radiate treatment on both hippocampus apricot kernel combined with the means of MST and heat treatment (the method was employed in 1 case); resecting affected area and denaturation constitution, transecting callosotomy in a selective way combined with the means of MST (the method was employed in 4 cases); resecting affected area, denaturation constitution,anterior temple lobe and hippocampus apricot kernel while using MST (the method was employed in 18 cases). Results: After relative treatments patients were followed up with the length of the follow-up ranging from 6 months to 11 years and judged by the Engel standard 26 of them could reach the level of Ⅰ,and 9 of them could reach the level of Ⅱ,all recovering completely; besides,20 of those patients could reach the level of Ⅲ,recovering well,and 6 of those patient who were followed up could reach the level of Ⅳ,which suggests that the ratio for total recovery could reach to 60.00% and the ratio for ideal recovery could amount to 90.77% and all those patients have demonstrated the sigh of getting better in terms of their intelligence. Conclusions: When dealing with refractory epilepsy concerning multiple focus of refractory epilepsy in surgical treatment,ideal and effective results could realized by employing appropriate but different surgical methods based on the different areas in epilepsy electroencephalogram.
2011, 36(7): 739-741.
Abstract:
Objective: To explore the related risk factors of ectopic pregnancy in nonparous women. Methods: Univariate analysis and unconditional multitivariate Logistic regression analysis are conducted on 75 nonporous cases with ectopic pregnancy and 150 nonporous cases with intrauterine early pregnancy from outpartient in the same time. Results: Cultural degree, drug abortion, artificital abortion, reproductive tract infection history, pelvic surgeries, number of sex partners, contraceptive methods seven factors caused the occurrence of nonporous ectopic pregnancy significant differences comparing with the control group (P < 0.05-P < 0.01). OR value of reproductive tract infection history, drug abortion, pelvic surgeries was greater than 1,by unconditional multitivariate Logistic regression analysis. Conclusions: Reproductive tract infection history, drug abortion, pelvic surgeries and so on are the main risk factors of ectopic pregnancy in nonparous women.
Objective: To explore the related risk factors of ectopic pregnancy in nonparous women. Methods: Univariate analysis and unconditional multitivariate Logistic regression analysis are conducted on 75 nonporous cases with ectopic pregnancy and 150 nonporous cases with intrauterine early pregnancy from outpartient in the same time. Results: Cultural degree, drug abortion, artificital abortion, reproductive tract infection history, pelvic surgeries, number of sex partners, contraceptive methods seven factors caused the occurrence of nonporous ectopic pregnancy significant differences comparing with the control group (P < 0.05-P < 0.01). OR value of reproductive tract infection history, drug abortion, pelvic surgeries was greater than 1,by unconditional multitivariate Logistic regression analysis. Conclusions: Reproductive tract infection history, drug abortion, pelvic surgeries and so on are the main risk factors of ectopic pregnancy in nonparous women.
2011, 36(7): 742-744.
Abstract:
Objective: To evaluate the clinical efficacy of transvaginal myomectomy. Methods: Of 76 patients with uterine myomas,30 cases were treated by transvaginal myomectomy(group A) and 46 cases by transabdominal myomectomy(group B). The duration of operation,bleeding volume during operation,hospital stay after operation and the time of bowel function recovery were compared between the two groups. Results: The operation was successful in all the cases in group A and no one resorted to transabdominal procedure. Group A were superior to group B in the duration of operation,bleeding volume during operation,hospital stay after operation and the time of bowel function recovery(P < 0.05-P < 0.01). Conclusions: Transvaginal myomectomy has the advantages of minimal invasion and rapid recovery. It is a low invasive and effective procedure for treatment of uterine myomas and is worth popularizing.
Objective: To evaluate the clinical efficacy of transvaginal myomectomy. Methods: Of 76 patients with uterine myomas,30 cases were treated by transvaginal myomectomy(group A) and 46 cases by transabdominal myomectomy(group B). The duration of operation,bleeding volume during operation,hospital stay after operation and the time of bowel function recovery were compared between the two groups. Results: The operation was successful in all the cases in group A and no one resorted to transabdominal procedure. Group A were superior to group B in the duration of operation,bleeding volume during operation,hospital stay after operation and the time of bowel function recovery(P < 0.05-P < 0.01). Conclusions: Transvaginal myomectomy has the advantages of minimal invasion and rapid recovery. It is a low invasive and effective procedure for treatment of uterine myomas and is worth popularizing.
2011, 36(7): 744-746.
Abstract:
Objective: To compare the efficacy of unilateral tonsillectomy + adenoidectomy with the efficacy of bilateral tonsillectomy + adenoidectomy in treatment of children with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods: Ninety-six cases with OSAHS children were randomly divided into two groups,group A underwent bilateral tonsillectomy + adenoidectomy,group B underwent unilateral tonsillectomy + adenoidectomy (modified group). Results: The patients were followed up six month to one year after the operation,there were no significant difference between two groups in treating the OSAHS(P > 0.05). The surgical approach of group B did not affect the curative effect on the children with OSAHS. Conclusions: The unilateral tonsillectomy + adenoidectomy could not only retain the physiological function of children's unilateral tonsil,but also treat the OSAHS effectively,which is an operation methord worth of promoting.
Objective: To compare the efficacy of unilateral tonsillectomy + adenoidectomy with the efficacy of bilateral tonsillectomy + adenoidectomy in treatment of children with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods: Ninety-six cases with OSAHS children were randomly divided into two groups,group A underwent bilateral tonsillectomy + adenoidectomy,group B underwent unilateral tonsillectomy + adenoidectomy (modified group). Results: The patients were followed up six month to one year after the operation,there were no significant difference between two groups in treating the OSAHS(P > 0.05). The surgical approach of group B did not affect the curative effect on the children with OSAHS. Conclusions: The unilateral tonsillectomy + adenoidectomy could not only retain the physiological function of children's unilateral tonsil,but also treat the OSAHS effectively,which is an operation methord worth of promoting.
Clinical application of serum squamous cell carcinoma antigen level in patients with cervical cancer
2011, 36(7): 760-761.
Abstract:
Objective: To determine the clinical value of the tumor marker squamous cell carcinoma antigen(SCCAg) in the diagnosis of cervical squamous cell carcinoma and to validate the sensitivity and specificity of chemiluminescence detection of SCCAg. Methods: The serum SCCAg levels in one hundred and forty cervical squamous carcinoma patients and one hundred and fifty healthy women controls were measured by ARCHITECT I2000SR automatic immuno-analyzer. Results: The levels of SCCAg in cervical squamous carcinoma patients and normal controls were (21.54 ±39.95) ng/ml and (0.69 ±0.42) ng/ml, respectively. There was a statistically significant difference between the two groups(P < 0.01). The positive rate of cervical squamous carcinoma patients was 86.4% (121/140) when > x+3s of normal control group(> 1.9 ng/ml) was used as a positive standard. Conclusions: SCCAg can be used as a specific marker in the diagnosis of cervical squamous cell carcinoma. It is a rapid, simple, accurate and specific method, which is also easy to be accepted by patients. Thus,the detection of SCCAg has a very important significance for the curative effect observation and the prognosis evaluation of cervical squamous cell carcinoma.
Objective: To determine the clinical value of the tumor marker squamous cell carcinoma antigen(SCCAg) in the diagnosis of cervical squamous cell carcinoma and to validate the sensitivity and specificity of chemiluminescence detection of SCCAg. Methods: The serum SCCAg levels in one hundred and forty cervical squamous carcinoma patients and one hundred and fifty healthy women controls were measured by ARCHITECT I2000SR automatic immuno-analyzer. Results: The levels of SCCAg in cervical squamous carcinoma patients and normal controls were (21.54 ±39.95) ng/ml and (0.69 ±0.42) ng/ml, respectively. There was a statistically significant difference between the two groups(P < 0.01). The positive rate of cervical squamous carcinoma patients was 86.4% (121/140) when > x+3s of normal control group(> 1.9 ng/ml) was used as a positive standard. Conclusions: SCCAg can be used as a specific marker in the diagnosis of cervical squamous cell carcinoma. It is a rapid, simple, accurate and specific method, which is also easy to be accepted by patients. Thus,the detection of SCCAg has a very important significance for the curative effect observation and the prognosis evaluation of cervical squamous cell carcinoma.
2011, 36(7): 762-764.
Abstract:
Objective: To investigate and analyze the current blood taking and supplying situations in Lu'an district systematically and supply corresponding strategies aiming at guaranteeing the safe and efficient blood supply. Methods: Based on the statistics of Lu' an district. The overall blood taking amounts,blood positive infection ratio,blood wasting ratio,clinical consumption amounts,the population and overall patient beddings from 2006 to 2009 were statistical analyzed. Results: The annual increase rate of blood taking was 18.2% in Lu'an,and the blood components transfusion was met to clinical requirement; the yearly amounts of machine blood platelet taking were pretty low,and it could not met the practical needs; blood positive rate and fat blood wasting ratios were steadily increased each year. The pressure of clinical blood consumption had increased continuously. Conclusions: In order to ensure safe and efficient blood supply,in addition to highly advertising blood donation and ensuring blood test accuracy,the health surveys should be earnestly carried out by related authorities prior to blood donation. The public education should be strengthened before blood donation,and the blood resources wasting should be minimized.
Objective: To investigate and analyze the current blood taking and supplying situations in Lu'an district systematically and supply corresponding strategies aiming at guaranteeing the safe and efficient blood supply. Methods: Based on the statistics of Lu' an district. The overall blood taking amounts,blood positive infection ratio,blood wasting ratio,clinical consumption amounts,the population and overall patient beddings from 2006 to 2009 were statistical analyzed. Results: The annual increase rate of blood taking was 18.2% in Lu'an,and the blood components transfusion was met to clinical requirement; the yearly amounts of machine blood platelet taking were pretty low,and it could not met the practical needs; blood positive rate and fat blood wasting ratios were steadily increased each year. The pressure of clinical blood consumption had increased continuously. Conclusions: In order to ensure safe and efficient blood supply,in addition to highly advertising blood donation and ensuring blood test accuracy,the health surveys should be earnestly carried out by related authorities prior to blood donation. The public education should be strengthened before blood donation,and the blood resources wasting should be minimized.
2011, 36(7): 765-766,769.
Abstract:
Objective: To strengthen the transfusion management of cryoprecipitate in clinical use and apply cryoprecipitate to reasonable patients in order to decrease occurrence of diseases which spread by transfusion and reduce abnormal transfusion reaction. Methods: The amounts of cryoprecipitate(units) that had been applied in the first affiliated hospital of Bengbu Medical College from 2008-2010 years and the cases in 2010 year were statistical analyzed. The reasonable use rate of cryoprecipitate and the unreasonable use rate were counted. Results: The annual average amounts of cryoprecipitate that had been applied in the years 2009 and 2010 were 3.4 times as many as in the year 2008. The reasonable use rate of cryoprecipitate was 43.8% and the unreasonable use rate was 56.2% in the year 2010. Conclusions: The amounts of cryoprecipitate that had been applied in the first affiliated hospital of Bengbu Medical College were excessive in the years 2009 and 2010. the unreasonable use rate of cryoprecipitate was high in the year 2010. So the transfusion management of cryoprecipitate should be strengthened in clinical uses,and the suitable cases should be strictly choosen and unnecessary transfusion of cryoprecipitate should be stopped.
Objective: To strengthen the transfusion management of cryoprecipitate in clinical use and apply cryoprecipitate to reasonable patients in order to decrease occurrence of diseases which spread by transfusion and reduce abnormal transfusion reaction. Methods: The amounts of cryoprecipitate(units) that had been applied in the first affiliated hospital of Bengbu Medical College from 2008-2010 years and the cases in 2010 year were statistical analyzed. The reasonable use rate of cryoprecipitate and the unreasonable use rate were counted. Results: The annual average amounts of cryoprecipitate that had been applied in the years 2009 and 2010 were 3.4 times as many as in the year 2008. The reasonable use rate of cryoprecipitate was 43.8% and the unreasonable use rate was 56.2% in the year 2010. Conclusions: The amounts of cryoprecipitate that had been applied in the first affiliated hospital of Bengbu Medical College were excessive in the years 2009 and 2010. the unreasonable use rate of cryoprecipitate was high in the year 2010. So the transfusion management of cryoprecipitate should be strengthened in clinical uses,and the suitable cases should be strictly choosen and unnecessary transfusion of cryoprecipitate should be stopped.
2011, 36(7): 775-777.
Abstract:
Objective: To investigate the success rate of ultrasound imaging in axillary sentinel limpth node (SLNs) detection by subcutaneous injection of ultrasound contrast agents. Methods: The ultrasonography were performed in 26 patients with breast cancer, and 1.0 ml of ultrasound contrast agent were injected subcutaneously around breast tumors(at 12,3,6,9 o' clock position) with the microbubbles of SonoVue. The nodes were considered as SLNs and positioned when the contrast agents were found in one or numbers of lymph nodes by real-time imaging. The SLNs were isolate and dissected during the surgery,and the success rates of ultrasound imaging were evaluate according to the pathological examination. Results: In all patients,the SLNs were detected in 23 cases,and 22 cases of them were confirmed by pathological examination,the success rate of ultrasound imaging was 84.62% (22/26). Conclusions: Contrastenhanced ultrasonography may be a useful method for SLNs detection.
Objective: To investigate the success rate of ultrasound imaging in axillary sentinel limpth node (SLNs) detection by subcutaneous injection of ultrasound contrast agents. Methods: The ultrasonography were performed in 26 patients with breast cancer, and 1.0 ml of ultrasound contrast agent were injected subcutaneously around breast tumors(at 12,3,6,9 o' clock position) with the microbubbles of SonoVue. The nodes were considered as SLNs and positioned when the contrast agents were found in one or numbers of lymph nodes by real-time imaging. The SLNs were isolate and dissected during the surgery,and the success rates of ultrasound imaging were evaluate according to the pathological examination. Results: In all patients,the SLNs were detected in 23 cases,and 22 cases of them were confirmed by pathological examination,the success rate of ultrasound imaging was 84.62% (22/26). Conclusions: Contrastenhanced ultrasonography may be a useful method for SLNs detection.
2011, 36(7): 778-780.
Abstract:
Objective: To investigate the infection rate and risk factors of patients in Intensive Care Unit(ICU),and explore the corresponding nursing measures. Methods: According to the WS/T312-2009 professional standards-Hospital Infection Monitoring Standards,the ICU patients who hospitalized during the period of Aug. 2009 to Mar. 2010 were under target monitoring,and the related risk factors of hospital infection were analyzed. Results: Among the 100 ICU patients who had been in hospital for more than 48 hours, 22 cases were shown hospital infection,with a rate of 22.00%. While 40 cases with an infection rate of 40.00% were shown hospital infection of 11.7% after the regulation of the average severity of illness. The use rate of urethral catheter,ventilator and venous cannula were 59.67%,37.66% and 58.22%,respectively. Meanwhile,the urinary tract infection rate related to urethral catheter was 6.28‰, the blood flow infection rate related to blood vessel canals was 1.61‰,and the rate of ventilator-associated pneumonia was 24.87‰. The majority of 49 detected pathogen were Gram-negative bacteria which occupied 71.43%,and were multiple antibiotic resistance. Conclusions: The rate of hospital infection in ICU is much higher than other divisions in hospital. In the use of instrument,the infection rate of urethral catheter is the highest,and the rate of ventilator-associated pneumonia is the highest in the appliance-related infection. Hospital infectious pathogens are mostly Gram-negative bacteria of multiple antibiotic resistance. So,preventive and control measures should be strengthened to cut off infection passages. Besides,basic and specialized nursing work should be well executed to effectively reduce the rate of hospital infection.
Objective: To investigate the infection rate and risk factors of patients in Intensive Care Unit(ICU),and explore the corresponding nursing measures. Methods: According to the WS/T312-2009 professional standards-Hospital Infection Monitoring Standards,the ICU patients who hospitalized during the period of Aug. 2009 to Mar. 2010 were under target monitoring,and the related risk factors of hospital infection were analyzed. Results: Among the 100 ICU patients who had been in hospital for more than 48 hours, 22 cases were shown hospital infection,with a rate of 22.00%. While 40 cases with an infection rate of 40.00% were shown hospital infection of 11.7% after the regulation of the average severity of illness. The use rate of urethral catheter,ventilator and venous cannula were 59.67%,37.66% and 58.22%,respectively. Meanwhile,the urinary tract infection rate related to urethral catheter was 6.28‰, the blood flow infection rate related to blood vessel canals was 1.61‰,and the rate of ventilator-associated pneumonia was 24.87‰. The majority of 49 detected pathogen were Gram-negative bacteria which occupied 71.43%,and were multiple antibiotic resistance. Conclusions: The rate of hospital infection in ICU is much higher than other divisions in hospital. In the use of instrument,the infection rate of urethral catheter is the highest,and the rate of ventilator-associated pneumonia is the highest in the appliance-related infection. Hospital infectious pathogens are mostly Gram-negative bacteria of multiple antibiotic resistance. So,preventive and control measures should be strengthened to cut off infection passages. Besides,basic and specialized nursing work should be well executed to effectively reduce the rate of hospital infection.
2011, 36(7): 781-782.
Abstract:
Objective: To explore the values of clinical nursing pathway(CNP) in obstetrics health education. Methods: Two hundred cases of expectant mothers were randomly divided into the control group or study group,and each including 100 cases. The control group received conventional health education. According to the characteristics of obstetrical care, the clinical path table was made, the systematic health education was implemented in the study group. Results: The level of knowledge during pregnancy,self-care ability, newborn care skills and the success rate of breastfeeding were remarkably higher in study group than that in control group(P < 0.01). Conclusions: CNP can well distribute the informations of breastfeeding and newborn care to mother and increase the success rate of breastfeeding. Furthermore,it also can represent humanistic nursing and improve the satisfaction rate of both patients and relatives.
Objective: To explore the values of clinical nursing pathway(CNP) in obstetrics health education. Methods: Two hundred cases of expectant mothers were randomly divided into the control group or study group,and each including 100 cases. The control group received conventional health education. According to the characteristics of obstetrical care, the clinical path table was made, the systematic health education was implemented in the study group. Results: The level of knowledge during pregnancy,self-care ability, newborn care skills and the success rate of breastfeeding were remarkably higher in study group than that in control group(P < 0.01). Conclusions: CNP can well distribute the informations of breastfeeding and newborn care to mother and increase the success rate of breastfeeding. Furthermore,it also can represent humanistic nursing and improve the satisfaction rate of both patients and relatives.
2011, 36(7): 783-785.
Abstract:
Objective: To study on the assessment of preoperative and postoperative nutrition in children with congenital heart disease, and provide reference for surgical program selection and nutrition support. Methods: The data of 62 cases of 5 to 6 years old children with congenital heart disease were collected from December 2008 to December 2009 in the department of cardiovascular surgery. The physical examination and laboratory test were done when these children had been admitted for 2 to 3 days, or received the surgery for 7 to 14 days. Results: the ratio of male to female is 1:0.9 in the 62 cases. The proportions of cases with normal nutrition, low weight, mild malnutrition and moderate malnutrition were 59.7%, 29.0%, 9.7% and 1.6% respectively. The height and weight of children with congenital heart disease were significantly lower than that of normal children with the same age. The preoperative weight, arm circumference, triceps skinfold thickness and lymphocyte counts in patients were lower than those of postoperative outcomes (P < 0.05). Conclusions: Compared with the children of normal development,the children with congenital heart disease had higher incidence of malnutrition. The nutritional intervention should be adopted to promote postoperative recovery based on the results of nutrition evaluation.
Objective: To study on the assessment of preoperative and postoperative nutrition in children with congenital heart disease, and provide reference for surgical program selection and nutrition support. Methods: The data of 62 cases of 5 to 6 years old children with congenital heart disease were collected from December 2008 to December 2009 in the department of cardiovascular surgery. The physical examination and laboratory test were done when these children had been admitted for 2 to 3 days, or received the surgery for 7 to 14 days. Results: the ratio of male to female is 1:0.9 in the 62 cases. The proportions of cases with normal nutrition, low weight, mild malnutrition and moderate malnutrition were 59.7%, 29.0%, 9.7% and 1.6% respectively. The height and weight of children with congenital heart disease were significantly lower than that of normal children with the same age. The preoperative weight, arm circumference, triceps skinfold thickness and lymphocyte counts in patients were lower than those of postoperative outcomes (P < 0.05). Conclusions: Compared with the children of normal development,the children with congenital heart disease had higher incidence of malnutrition. The nutritional intervention should be adopted to promote postoperative recovery based on the results of nutrition evaluation.
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