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2012 Vol. 37, No. 6
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2012, 36(6): 621-623,626.
Abstract:
Objective:To investigate the change of T lymphocyte subsets in peripheral blood of SD rats with acute spinal cord injury(SCI).Methods:Twenty two SD rats(11 each male and female) were used to establish SCI model using NYU Spinal Cord Contusion Impactor System.The CD3 +,CD3 + CD4 + and CD3 +,CD8 + T cells,and the proportion of CD3 + CD4 + to CD3+ CD8+ T cells of peripheral blood of all rats were evaluated using flow cytometry at the time points of preinjury and days 1,3,5,7and 14 postinjury.Results:The percentages of CD3+ CD8+ cells had no significant difference among before SCI,the 1st,7th and 14th day after SCI,butthe percentage of CD3+,CD8+ T cells at the 3rd,5th day was higher than at the 14th day after SCT and before SCI.The percentages of CD3+ and CD3+ CD4+ T cells,and ratio of CD3+ CD4+ to CD3+ CD8+ T cells at days 1,3,5 and 7 post-injury were significantly lowerthan those of at preinjury(P 0.01).After 14 days postinjury,all T lymphocyte subsets were restored to preoperative level,which wereno differences with preinjury(P 0.05).Conclusions:After acute SCI,the total of T cells and CD4+ T cells and the ratio of CD3+ CD4+ to CD3+ CD8+ T cells decrease,which suggest there may be T cell function abnormalities in the early stage of SCI in rat model.
Objective:To investigate the change of T lymphocyte subsets in peripheral blood of SD rats with acute spinal cord injury(SCI).Methods:Twenty two SD rats(11 each male and female) were used to establish SCI model using NYU Spinal Cord Contusion Impactor System.The CD3 +,CD3 + CD4 + and CD3 +,CD8 + T cells,and the proportion of CD3 + CD4 + to CD3+ CD8+ T cells of peripheral blood of all rats were evaluated using flow cytometry at the time points of preinjury and days 1,3,5,7and 14 postinjury.Results:The percentages of CD3+ CD8+ cells had no significant difference among before SCI,the 1st,7th and 14th day after SCI,butthe percentage of CD3+,CD8+ T cells at the 3rd,5th day was higher than at the 14th day after SCT and before SCI.The percentages of CD3+ and CD3+ CD4+ T cells,and ratio of CD3+ CD4+ to CD3+ CD8+ T cells at days 1,3,5 and 7 post-injury were significantly lowerthan those of at preinjury(P 0.01).After 14 days postinjury,all T lymphocyte subsets were restored to preoperative level,which wereno differences with preinjury(P 0.05).Conclusions:After acute SCI,the total of T cells and CD4+ T cells and the ratio of CD3+ CD4+ to CD3+ CD8+ T cells decrease,which suggest there may be T cell function abnormalities in the early stage of SCI in rat model.
2012, 36(6): 624-626.
Abstract:
Objective:To detect the expressions of Toll like receptor 2(TLR2) and Toll like receptor 4(TLR4) on neutrophils in tuberculosis patients before and after infection of Mycobacterium tuberculosis(M.tb) in vitro and explore their significances.Methods:The expressions of TLR2 and TLR4 on neutrophils in tuberculosis patients and healthy adults from peripheral blood were determined respectively by flow cytometry.And then after infection of M.tb in vitro,the expressions of TLR2 and TLR4 were determined.Results:The expressions of TLR2 and TLR4 in tuberculosis patients were obviously higher than those in healthy adults(P0.01).And after infection of M.tb in vitro,the expressions of TLR2 and TLR4 in tuberculosis patients and healthy adults were obviously lower than before infection of M.tb(P0.01).Conclusions:The results indicate that the expressions and activations of TLR2 and TLR4 on neutrophils in tuberculosis patients can help to resist infection of M.tb,and TLR2 and TLR4 take part in immune response to infection of M.tb.
Objective:To detect the expressions of Toll like receptor 2(TLR2) and Toll like receptor 4(TLR4) on neutrophils in tuberculosis patients before and after infection of Mycobacterium tuberculosis(M.tb) in vitro and explore their significances.Methods:The expressions of TLR2 and TLR4 on neutrophils in tuberculosis patients and healthy adults from peripheral blood were determined respectively by flow cytometry.And then after infection of M.tb in vitro,the expressions of TLR2 and TLR4 were determined.Results:The expressions of TLR2 and TLR4 in tuberculosis patients were obviously higher than those in healthy adults(P0.01).And after infection of M.tb in vitro,the expressions of TLR2 and TLR4 in tuberculosis patients and healthy adults were obviously lower than before infection of M.tb(P0.01).Conclusions:The results indicate that the expressions and activations of TLR2 and TLR4 on neutrophils in tuberculosis patients can help to resist infection of M.tb,and TLR2 and TLR4 take part in immune response to infection of M.tb.
2012, 36(6): 627-629.
Abstract:
Objective:To explore the recurrence mechanism of gastric ulcer and intervention of dendrobium polysaccharides in rats.Methods:The experimental animals were divided into normal group,no recurrence model group,recurrence model group,dendrobium polysaccharide and omeprazole group,dendrobium polysaccharide group and omeprazole group.The recurrence gastric ulcer model was developed by using intraperitoneal injection with interleukin-1.The pathohistological structure of the recurrence gastric ulcer were observed after treatment with dendrobium polysaccharides for 90 days,and the activities of the superoxide dismutase(SOD) and the contents of malondialdehyde(MDA) of gastric mucosa were determined.Results:The activities of SOD of dendrobium polysaccharide and omeprazole group and dendrobium polysaccharide group were significantly improved(P0.01),and the contents of MDA of all groups had no statistical difference(P0.05).The recurrence of gastric ulcer of dendrobium polysaccharide and omeprazole group decresed.Conclusions:The recurrence of the gastric ulcer is related to free radical.Dendrobium polysaccharide and omeprazole can inhibit the recurrence of the gastric ulcer,which mechanism is probably related to anti-oxidation capacity.
Objective:To explore the recurrence mechanism of gastric ulcer and intervention of dendrobium polysaccharides in rats.Methods:The experimental animals were divided into normal group,no recurrence model group,recurrence model group,dendrobium polysaccharide and omeprazole group,dendrobium polysaccharide group and omeprazole group.The recurrence gastric ulcer model was developed by using intraperitoneal injection with interleukin-1.The pathohistological structure of the recurrence gastric ulcer were observed after treatment with dendrobium polysaccharides for 90 days,and the activities of the superoxide dismutase(SOD) and the contents of malondialdehyde(MDA) of gastric mucosa were determined.Results:The activities of SOD of dendrobium polysaccharide and omeprazole group and dendrobium polysaccharide group were significantly improved(P0.01),and the contents of MDA of all groups had no statistical difference(P0.05).The recurrence of gastric ulcer of dendrobium polysaccharide and omeprazole group decresed.Conclusions:The recurrence of the gastric ulcer is related to free radical.Dendrobium polysaccharide and omeprazole can inhibit the recurrence of the gastric ulcer,which mechanism is probably related to anti-oxidation capacity.
2012, 36(6): 630-632.
Abstract:
Objective:To explore the expression and significance of Caspase-3 in mouse with embryonic neural tube defects(NTD) induced by retinoic acid(RA).Methods:The 40 mice were randomly divided into test and control groups.The neural tubal samples were harvested at 18,42,66 and 90 h after RA or arachis oil administration.Western blotting was used to detect the expression of Caspase-3.Results:The expression of Caspase-3 displayed time dependence in the normal fetal neural tube tissue.In control group,the expression level of Caspase-3 increased at 18 h,and achieved the most peak at 42 and 66 h,then decreased slowly after arachis oil administration.In test group,the expression levels of Caspase-3 were significant lower than that of control group at 42 h(P0.01),and significant higher than that of normal group at 66 h and 90 h after treatment with RA(P0.01).Conclusions:RA can change the expression pattern of Caspase-3 in embryonic neural tube of mouse,The Caspase-3 alteration may participate in the formation of NTD induced by RA.
Objective:To explore the expression and significance of Caspase-3 in mouse with embryonic neural tube defects(NTD) induced by retinoic acid(RA).Methods:The 40 mice were randomly divided into test and control groups.The neural tubal samples were harvested at 18,42,66 and 90 h after RA or arachis oil administration.Western blotting was used to detect the expression of Caspase-3.Results:The expression of Caspase-3 displayed time dependence in the normal fetal neural tube tissue.In control group,the expression level of Caspase-3 increased at 18 h,and achieved the most peak at 42 and 66 h,then decreased slowly after arachis oil administration.In test group,the expression levels of Caspase-3 were significant lower than that of control group at 42 h(P0.01),and significant higher than that of normal group at 66 h and 90 h after treatment with RA(P0.01).Conclusions:RA can change the expression pattern of Caspase-3 in embryonic neural tube of mouse,The Caspase-3 alteration may participate in the formation of NTD induced by RA.
2012, 36(6): 633-635.
Abstract:
Objective:To explore the effects and mechanism of dendritic cells(DC) induced by nuclear factor-B(NF-B) oligodeoxynucleotide(ODN) in rats with type Ⅱ collagen-induced arthritis(CIA).Methods:The model rats with arthritic were established by type Ⅱ collagen inducing.DC from rat spleen treated with NF-B ODN were injected to caudal vein of CIA rats at 5 days after the initial immunization.The change of paw-swelling,the index of arthritis and pathogenic indicator of the control group,CIA model group and experimental group were observed after 42 days.Results:The OX62 expression on the DC surface of three groups were above 70%,there was no significant difference(P0.05).The CD80 postive cells of CIA model group and experimental group had significant difference(P0.01).The CD80 and CD86 average fluorescence intensity of experimental group was significantly higher than that of CIA model group(P0.01).At 7 days primary immune,the arthritis index of CIA model group and experimental group began to increase,the arthritis index of experimental group were significantly lower than that of CIA model group at 21 days(P0.01).Conclusions:The DC induced by NF-B ODN can effectively relieve the arthritis symptoms and histopathology damage of CIA rats,and have good curative effects on rheumatoid arthritis.
Objective:To explore the effects and mechanism of dendritic cells(DC) induced by nuclear factor-B(NF-B) oligodeoxynucleotide(ODN) in rats with type Ⅱ collagen-induced arthritis(CIA).Methods:The model rats with arthritic were established by type Ⅱ collagen inducing.DC from rat spleen treated with NF-B ODN were injected to caudal vein of CIA rats at 5 days after the initial immunization.The change of paw-swelling,the index of arthritis and pathogenic indicator of the control group,CIA model group and experimental group were observed after 42 days.Results:The OX62 expression on the DC surface of three groups were above 70%,there was no significant difference(P0.05).The CD80 postive cells of CIA model group and experimental group had significant difference(P0.01).The CD80 and CD86 average fluorescence intensity of experimental group was significantly higher than that of CIA model group(P0.01).At 7 days primary immune,the arthritis index of CIA model group and experimental group began to increase,the arthritis index of experimental group were significantly lower than that of CIA model group at 21 days(P0.01).Conclusions:The DC induced by NF-B ODN can effectively relieve the arthritis symptoms and histopathology damage of CIA rats,and have good curative effects on rheumatoid arthritis.
2012, 36(6): 636-638.
Abstract:
Objective:To observe clinical effects of monosialotetrahexosyl ganglioside on neonates with hypoxic-ischemic encephalopathy.Methods:Sixty-two neonates with hypoxic-ischemic encephalopathy were randomly divided into the treatment group and the control group.The control group was treated with conventional way;and the treatment group was treated with conventional way combined with monosialotetrahexosyl ganglioside intravenous drip(20 mg per day)for 10-14 days.The recovery of the clinical symptoms and behavioral neurological assessment scores of all neonates were compared.Results:The clinical symptoms and behavioral neurological assessment scores of the treatment group were better than that of the control group(P0.01).Conclusions:The early treatment for neonates with hypoxic-ischemic encephalopathy with monosialotetrahexosyl ganglioside have significant effects and no adverse reactions.
Objective:To observe clinical effects of monosialotetrahexosyl ganglioside on neonates with hypoxic-ischemic encephalopathy.Methods:Sixty-two neonates with hypoxic-ischemic encephalopathy were randomly divided into the treatment group and the control group.The control group was treated with conventional way;and the treatment group was treated with conventional way combined with monosialotetrahexosyl ganglioside intravenous drip(20 mg per day)for 10-14 days.The recovery of the clinical symptoms and behavioral neurological assessment scores of all neonates were compared.Results:The clinical symptoms and behavioral neurological assessment scores of the treatment group were better than that of the control group(P0.01).Conclusions:The early treatment for neonates with hypoxic-ischemic encephalopathy with monosialotetrahexosyl ganglioside have significant effects and no adverse reactions.
2012, 36(6): 639-640.
Abstract:
Objective:To investigate the diagnostic threshold of serum level of 1,3--D-glucan(BDG) for invasive fungal disease(IFD),and evaluate its clinical significance.Methods:Total serum samples of 34 IFD patients and 105 non-IFD cases were collected,BDG level was detected by kinetic turbidimetric limulus test,ROC curve analysis was used to determine the optimal diagnostic value of BDG.Results:ROC analysis showed that the area under the ROC curve of BDG was 0.921 and the optimal diagnostic threshold was33.76 pg/ml,the corresponding sensitivity,specificity,positive predictive value and negative predictive values were 88.2%,87.6%,69.8% and 95.8%,respectively.Conclusions:Serum BDG can serve as a good diagnostic indicator for IFD and the cut-off value of33.76 pg/ml plays the highest diagnostic efficiency,but it needs to combine with other examinations and clinical risk factors.
Objective:To investigate the diagnostic threshold of serum level of 1,3--D-glucan(BDG) for invasive fungal disease(IFD),and evaluate its clinical significance.Methods:Total serum samples of 34 IFD patients and 105 non-IFD cases were collected,BDG level was detected by kinetic turbidimetric limulus test,ROC curve analysis was used to determine the optimal diagnostic value of BDG.Results:ROC analysis showed that the area under the ROC curve of BDG was 0.921 and the optimal diagnostic threshold was33.76 pg/ml,the corresponding sensitivity,specificity,positive predictive value and negative predictive values were 88.2%,87.6%,69.8% and 95.8%,respectively.Conclusions:Serum BDG can serve as a good diagnostic indicator for IFD and the cut-off value of33.76 pg/ml plays the highest diagnostic efficiency,but it needs to combine with other examinations and clinical risk factors.
2012, 36(6): 641-643.
Abstract:
Objective:To explore risk factors of surgical site infection(SSI) of low transverse cesarean section.Methods:The data of 3 765 cases with low transverse cesarean section were retrospective analysed,150 cases with SSI and other 420 control cases were compared,and risk factors were analysed using mono-factor and multi-factor methods.Results:Analysis results showed that SSI was associated with chorioamnionitis,times of vaginal examination,development of subcutaneous hematoma after operation and high body mass index(BMI) at admission hospital(P0.01).Multivariate analysis showed that the times of vaginal examination,development of subcutaneous hematoma after operation and high BMI at admission hospital were the three risk factors(P0.05-P0.01) except chorioamnionitis.Conclusions:The times of vaginal examination,development of subcutaneous hematoma after operation and high BMI at admission hospital can improve the risk of SSI,which suggest that these high risk patiens must be strengthened the monitoring management to prevent SSI.
Objective:To explore risk factors of surgical site infection(SSI) of low transverse cesarean section.Methods:The data of 3 765 cases with low transverse cesarean section were retrospective analysed,150 cases with SSI and other 420 control cases were compared,and risk factors were analysed using mono-factor and multi-factor methods.Results:Analysis results showed that SSI was associated with chorioamnionitis,times of vaginal examination,development of subcutaneous hematoma after operation and high body mass index(BMI) at admission hospital(P0.01).Multivariate analysis showed that the times of vaginal examination,development of subcutaneous hematoma after operation and high BMI at admission hospital were the three risk factors(P0.05-P0.01) except chorioamnionitis.Conclusions:The times of vaginal examination,development of subcutaneous hematoma after operation and high BMI at admission hospital can improve the risk of SSI,which suggest that these high risk patiens must be strengthened the monitoring management to prevent SSI.
2012, 36(6): 644-646.
Abstract:
Objective:To explore the incidence and relative factors of post-stroke depression(PSD) at acute stage of cerebral stroke,so as to provide a basis for intervening PSD.Methods:One hundred and twenty-five cases with cerebral stroke were investigated by a self-designed questionnaire,divided into PSD group(41 cases) and non-PSD group(84 cases) according to the score of 17-item Hamilton depression rating scales,and evaluated using neurologic deficit scale and activities of daily living scale.Results:The incidence of PSD was 32.80%.Sex,age,economical status,location of damages,number of lesions,neurologic deficits and activities of daily living of patients were related with PSD,and its differences were statistical significance(P0.05-P0.01).But there were no significant differences in levels of education,marital status and nature of stroke(P0.05).Conclusions:The incidence of PSD of patients with cerebal stroke at acute stage is high,most PSD patients are mild and moderate and influenced by many factors.
Objective:To explore the incidence and relative factors of post-stroke depression(PSD) at acute stage of cerebral stroke,so as to provide a basis for intervening PSD.Methods:One hundred and twenty-five cases with cerebral stroke were investigated by a self-designed questionnaire,divided into PSD group(41 cases) and non-PSD group(84 cases) according to the score of 17-item Hamilton depression rating scales,and evaluated using neurologic deficit scale and activities of daily living scale.Results:The incidence of PSD was 32.80%.Sex,age,economical status,location of damages,number of lesions,neurologic deficits and activities of daily living of patients were related with PSD,and its differences were statistical significance(P0.05-P0.01).But there were no significant differences in levels of education,marital status and nature of stroke(P0.05).Conclusions:The incidence of PSD of patients with cerebal stroke at acute stage is high,most PSD patients are mild and moderate and influenced by many factors.
2012, 36(6): 647-649.
Abstract:
Objective:To improve the positioning accuracy of radiotherapy by improving the phantom fixation in radiotherapy of thoracic cancer.Methods:Twenty casess with thoracic cancer were randomly divided into conventional fixation group(without window) and mdoifed phantom fixation group(window),the setup accuracy of marked method of two groups were compared.Results:The average position error of Y-axis and X-axis of mdoifed phantom fixation group was significantly less than that of conventional fixation group from 1 to 4 weeks(P0.01) and the third week of radiotherapy respectively(P0.05-P0.01),and the data of Z-axis had no statistically significant difference(P0.05).Conclusions:The modified phantom fixation method can significantly improve the positioning accuracy of radiotherapy,which can provide the basis of rational use of phantom.
Objective:To improve the positioning accuracy of radiotherapy by improving the phantom fixation in radiotherapy of thoracic cancer.Methods:Twenty casess with thoracic cancer were randomly divided into conventional fixation group(without window) and mdoifed phantom fixation group(window),the setup accuracy of marked method of two groups were compared.Results:The average position error of Y-axis and X-axis of mdoifed phantom fixation group was significantly less than that of conventional fixation group from 1 to 4 weeks(P0.01) and the third week of radiotherapy respectively(P0.05-P0.01),and the data of Z-axis had no statistically significant difference(P0.05).Conclusions:The modified phantom fixation method can significantly improve the positioning accuracy of radiotherapy,which can provide the basis of rational use of phantom.
2012, 36(6): 650-652.
Abstract:
Objective:To investigate the clinicopathological features,immunophenotype and molecular genetics of enteropathic T-cell lymphoma(ETCL).Methods:The histopathological appearance,the immunophenotype,immunoglobulin heavy chain,the gene clonality rearrangement of T-cell receptor(TCR) of a ETCL cases were observed,and relevant references were reviewed.Results:Segmental ulcers were found in ileum and right colon.Superficial ulcer involving the ileal mucosa and submucosa,the deeper ulcerative lesions invasing the full thickness and abnormal lymphocytes encroached all layers of the intestinal wall in the context of inflammation of ileum and colon were observed under microscope.According to immunophenotype,the immunophenotype of CD43+,CD45RO+,CD56+,TIA1+,GB+ and PF+ of the tumor cells presented postive results,but the expression of CD3-,CD3(monoclone) CD30-,EMA-,CD20-and CD79a were negative.According to TCR- gene rearrangement,JVⅠ and JVⅡshowed positive,and the result of hybridization in situ of EBER was negative.Conclusions:ETCL occurs most in young men with no specific symptoms.Its progresses is rapidly and the result of prognosis is poor.The multiple ulcer in intestinal canal and TCR- gene rearrangement are its main characteristic.
Objective:To investigate the clinicopathological features,immunophenotype and molecular genetics of enteropathic T-cell lymphoma(ETCL).Methods:The histopathological appearance,the immunophenotype,immunoglobulin heavy chain,the gene clonality rearrangement of T-cell receptor(TCR) of a ETCL cases were observed,and relevant references were reviewed.Results:Segmental ulcers were found in ileum and right colon.Superficial ulcer involving the ileal mucosa and submucosa,the deeper ulcerative lesions invasing the full thickness and abnormal lymphocytes encroached all layers of the intestinal wall in the context of inflammation of ileum and colon were observed under microscope.According to immunophenotype,the immunophenotype of CD43+,CD45RO+,CD56+,TIA1+,GB+ and PF+ of the tumor cells presented postive results,but the expression of CD3-,CD3(monoclone) CD30-,EMA-,CD20-and CD79a were negative.According to TCR- gene rearrangement,JVⅠ and JVⅡshowed positive,and the result of hybridization in situ of EBER was negative.Conclusions:ETCL occurs most in young men with no specific symptoms.Its progresses is rapidly and the result of prognosis is poor.The multiple ulcer in intestinal canal and TCR- gene rearrangement are its main characteristic.
2012, 36(6): 653-654.
Abstract:
Objective:To explore the diagnosis,surgical treatment and preoperative management for esophageal cancer,improve preoperative diagnosis rate,curative effect and reduce complications.Methods:All of 80 cases were diagnosed by barium meal radiography and gastroscope,and all were treated with surgical methods and carefully preoperative management.Results:Surgical radical resection rate was 97.5%(78/80).Postoperative complications were including 6 cases of leakage,1 case of anastomotic stricture,2 cases of anastomotic bleeding,1 case of chylothorax and 9 cases of lung infection.There was no death case during one month after operation.Conclusions:Esophageal cancer must be diagnosed by barium meal and gastroscope,which can reduce the rate of missed diagnosis.Doing a good preoperative management is helpful to improve the resection rate of the tumor,reduce the complications and improve the prognosis of esophageal cancer.
Objective:To explore the diagnosis,surgical treatment and preoperative management for esophageal cancer,improve preoperative diagnosis rate,curative effect and reduce complications.Methods:All of 80 cases were diagnosed by barium meal radiography and gastroscope,and all were treated with surgical methods and carefully preoperative management.Results:Surgical radical resection rate was 97.5%(78/80).Postoperative complications were including 6 cases of leakage,1 case of anastomotic stricture,2 cases of anastomotic bleeding,1 case of chylothorax and 9 cases of lung infection.There was no death case during one month after operation.Conclusions:Esophageal cancer must be diagnosed by barium meal and gastroscope,which can reduce the rate of missed diagnosis.Doing a good preoperative management is helpful to improve the resection rate of the tumor,reduce the complications and improve the prognosis of esophageal cancer.
2012, 36(6): 655-657.
Abstract:
Objective:To investigate the incidence,causes and treatment measures of acute kidney injury(AKI) and provide the basis for early prevention.Methods:The causes,clinical manifestations,severity and treatment and prognosis of 56 cases were retrospectively analysed.Results:There were no significant difference in transitions of patients with the different causes,higher mortalities in cases with higher grade of AKI(P0.05),and the similar mortalities in cases with dialysis and non-dialysis(P0.05).Conclusions:The recovery of AKI is closely related to its causes and classification.The case treated with dialysis is not obviously improved.The early diagnosis and treatment of AKI can improve recovery and survival rate.
Objective:To investigate the incidence,causes and treatment measures of acute kidney injury(AKI) and provide the basis for early prevention.Methods:The causes,clinical manifestations,severity and treatment and prognosis of 56 cases were retrospectively analysed.Results:There were no significant difference in transitions of patients with the different causes,higher mortalities in cases with higher grade of AKI(P0.05),and the similar mortalities in cases with dialysis and non-dialysis(P0.05).Conclusions:The recovery of AKI is closely related to its causes and classification.The case treated with dialysis is not obviously improved.The early diagnosis and treatment of AKI can improve recovery and survival rate.
2012, 36(6): 658-660.
Abstract:
Objective:To observe the efficacy of quinapril combined with bisoprolol in patients with dilated cardiomyopathy(DCM).Methods:Seventy-six cases with DCM were randomly divided into control group and treated group,38 cases in each group.The patients in control group were treated with conventional treatment,and others in treated group were treated with quinapril and bisoprolol on the basis of conventional treatment,and the course of treatment was for one year.The clinical efficacy,mortality,cardiac function and cardiac structural changes were observed before and after treatment.Results:After treatment,the total effective rate was 92.1% and mortality rate was 7.9% in treated group,which were significantly better than in control group,the total effective rate was 63.2%(P0.01) and mortality rate was 28.9%(P0.05).After treatment,the parameters of heart function were significantly improved than pre-treatment in treated group.Left ventriular endsystolic dimension were significantly reduced compared with control group(P0.01),stroke volume,heart rate and ejection fraction were improved significantly compared with control group(P0.01).Conclusions:Quinapril combined with bisoprolol can significantly improve clinical efficacy of DCM and cardiac function,reduce mortality and improve cardiac structure,which can be further applied in treatment of DCM.
Objective:To observe the efficacy of quinapril combined with bisoprolol in patients with dilated cardiomyopathy(DCM).Methods:Seventy-six cases with DCM were randomly divided into control group and treated group,38 cases in each group.The patients in control group were treated with conventional treatment,and others in treated group were treated with quinapril and bisoprolol on the basis of conventional treatment,and the course of treatment was for one year.The clinical efficacy,mortality,cardiac function and cardiac structural changes were observed before and after treatment.Results:After treatment,the total effective rate was 92.1% and mortality rate was 7.9% in treated group,which were significantly better than in control group,the total effective rate was 63.2%(P0.01) and mortality rate was 28.9%(P0.05).After treatment,the parameters of heart function were significantly improved than pre-treatment in treated group.Left ventriular endsystolic dimension were significantly reduced compared with control group(P0.01),stroke volume,heart rate and ejection fraction were improved significantly compared with control group(P0.01).Conclusions:Quinapril combined with bisoprolol can significantly improve clinical efficacy of DCM and cardiac function,reduce mortality and improve cardiac structure,which can be further applied in treatment of DCM.
2012, 36(6): 661-662.
Abstract:
Objective:To investigate the clinical application of central lymph node dissection in differentiation thyroid carcinoma(DTC) with cervical lymph node negative(cN0 stage).Methods:Thirty-six cases(39 sides) with cN0 DTC were treated with central lymph node dissection,and the clinical effects were observed after surgery.Results:The positive rates of central lymph node were 41.03%(16/39).One case appeared transient hoarseness,and no permanent hypocalcemia convulsions and other complications were found.All cases were followed up for 1 to 6 years,3 cases with lymph node-positive in Ⅵ District recurred carcinoma,who were treated with lateral lymph node dissection again.Conclusions:Central lymph node metastasis of differentiated thyroid carcinoma with cN0 stage is in common,central lymph node dissection for treating differentiated thyroid carcinoma is safe and feasible.
Objective:To investigate the clinical application of central lymph node dissection in differentiation thyroid carcinoma(DTC) with cervical lymph node negative(cN0 stage).Methods:Thirty-six cases(39 sides) with cN0 DTC were treated with central lymph node dissection,and the clinical effects were observed after surgery.Results:The positive rates of central lymph node were 41.03%(16/39).One case appeared transient hoarseness,and no permanent hypocalcemia convulsions and other complications were found.All cases were followed up for 1 to 6 years,3 cases with lymph node-positive in Ⅵ District recurred carcinoma,who were treated with lateral lymph node dissection again.Conclusions:Central lymph node metastasis of differentiated thyroid carcinoma with cN0 stage is in common,central lymph node dissection for treating differentiated thyroid carcinoma is safe and feasible.
2012, 36(6): 663-665.
Abstract:
Objective:To investigate the effect of gestrinone on oxidative stress in endometriosis patient after individual laparoscopic surgery.Methods:One hundred endometriosis patients subjected to individual laparoscopic surgery were selected.According to whether taking gestrinone,the patients were randomly divided into experimental group(n=50) and control group(n=50).The oxidative stress indicators,reactive oxygen species(ROS) concentration,serum malondialdehyde(MDA) concentration,superoxide dismutase(SOD) activity and glutathione peroxidase(GSH-Px) activity were detected in four different time points.Results:Seven days after operation,oxidative stress was still increased in experimental group,but in contrast to control group,the levels of ROS and MDA were decreased(P0.01),after 1 month later,oxidative stress had corrected,serum ROS and MDA levels had reduced significantly(P0.01),while serum SOD and GSH-Px levels had significantly increased(P0.05).Conclusions:Gestrinone can reverse oxidative stress condition in endometriosis patients after individual laparoscopic surgery.
Objective:To investigate the effect of gestrinone on oxidative stress in endometriosis patient after individual laparoscopic surgery.Methods:One hundred endometriosis patients subjected to individual laparoscopic surgery were selected.According to whether taking gestrinone,the patients were randomly divided into experimental group(n=50) and control group(n=50).The oxidative stress indicators,reactive oxygen species(ROS) concentration,serum malondialdehyde(MDA) concentration,superoxide dismutase(SOD) activity and glutathione peroxidase(GSH-Px) activity were detected in four different time points.Results:Seven days after operation,oxidative stress was still increased in experimental group,but in contrast to control group,the levels of ROS and MDA were decreased(P0.01),after 1 month later,oxidative stress had corrected,serum ROS and MDA levels had reduced significantly(P0.01),while serum SOD and GSH-Px levels had significantly increased(P0.05).Conclusions:Gestrinone can reverse oxidative stress condition in endometriosis patients after individual laparoscopic surgery.
2012, 36(6): 666-668.
Abstract:
Objective:To investigate the fluctuation of the serum level of estradiol in patients with hypertensive intracerebral hemorrhage and the relation of the severity and prognosis of cerebral hemorrhage.Methods:The serum level of estradiol in 168 patients and 60 healthy persons was determined.All the patients were scored by U.S.National Institutes of Health Stroke Scale(NIHSS),and compared in groups.Results:There was significant difference in the serum level of estradiol in patients with cerebral hemorrhage in comparison with that of controls(P0.01),there was significant difference in the serum level of estradiol and the degree of seriousness of the male patient's condition and the bleeding(P0.05),there was no correlation in the serum level of estradiol and the degree of seriousness of the female patient's condition and the bleeding(P0.05),the serum level of estradiol in the patients of the improved group was obviously higher than that of the unchanged group and the deterioration group(P0.05 to P0.01).Conclusions:It is helpful for judging prognosis to determine the serum level of estradiol in patients with Hypertensive intracerebral hemorrhage.
Objective:To investigate the fluctuation of the serum level of estradiol in patients with hypertensive intracerebral hemorrhage and the relation of the severity and prognosis of cerebral hemorrhage.Methods:The serum level of estradiol in 168 patients and 60 healthy persons was determined.All the patients were scored by U.S.National Institutes of Health Stroke Scale(NIHSS),and compared in groups.Results:There was significant difference in the serum level of estradiol in patients with cerebral hemorrhage in comparison with that of controls(P0.01),there was significant difference in the serum level of estradiol and the degree of seriousness of the male patient's condition and the bleeding(P0.05),there was no correlation in the serum level of estradiol and the degree of seriousness of the female patient's condition and the bleeding(P0.05),the serum level of estradiol in the patients of the improved group was obviously higher than that of the unchanged group and the deterioration group(P0.05 to P0.01).Conclusions:It is helpful for judging prognosis to determine the serum level of estradiol in patients with Hypertensive intracerebral hemorrhage.
2012, 36(6): 669-671.
Abstract:
Objective:To investigate the influence of lipoprotein(a) on the residual lesion stenosis of the infarction-related arteries in acute myocardial infarction(MI) patients in whom reperfusion therapy was not performed.To explore the function of Lp(a) in the natural course of MI.Methods:One hundred and twenty-four MI patients who not given reperfusion therapy were underwent coronary angiography in chronic stage.Morning fasting blood was collected and Lp(a),blood sugar,total cholesterol(TC) and triglycerides(TG) were measured.Residual stenosis and TIMI classification were compared between the low Lp(a) group(300 mg/L) and the high Lp(a) group(300 mg/L),non-DM and DM,low-TC(5.69 mmol/L) and high-TC(5.69 mmol/L),low-TG(1.69 mmol/L) and high-TG(1.69 mmol/L) groups.Results:Residual stenosis was more severe in high Lp(a) level group than in low Lp(a) level group(P0.01).TIMI classification in high Lp(a) level group is lower(P0.05).Conclusions:These findings suggest that elevated Lp(a) level aggravate residual lesion stenosis of the infarction-related arteries acute MI patients in whom reperfusion therapy is not performed.The measurement of serum Lp(a) level is propitious to observe the nature course of MI,it might be diagnosable and prognostic factor to evaluate the effect of thrombolytic therapy.
Objective:To investigate the influence of lipoprotein(a) on the residual lesion stenosis of the infarction-related arteries in acute myocardial infarction(MI) patients in whom reperfusion therapy was not performed.To explore the function of Lp(a) in the natural course of MI.Methods:One hundred and twenty-four MI patients who not given reperfusion therapy were underwent coronary angiography in chronic stage.Morning fasting blood was collected and Lp(a),blood sugar,total cholesterol(TC) and triglycerides(TG) were measured.Residual stenosis and TIMI classification were compared between the low Lp(a) group(300 mg/L) and the high Lp(a) group(300 mg/L),non-DM and DM,low-TC(5.69 mmol/L) and high-TC(5.69 mmol/L),low-TG(1.69 mmol/L) and high-TG(1.69 mmol/L) groups.Results:Residual stenosis was more severe in high Lp(a) level group than in low Lp(a) level group(P0.01).TIMI classification in high Lp(a) level group is lower(P0.05).Conclusions:These findings suggest that elevated Lp(a) level aggravate residual lesion stenosis of the infarction-related arteries acute MI patients in whom reperfusion therapy is not performed.The measurement of serum Lp(a) level is propitious to observe the nature course of MI,it might be diagnosable and prognostic factor to evaluate the effect of thrombolytic therapy.
2012, 36(6): 672-673.
Abstract:
Objective:To investigate the efficacy of comprehensive interventions combined with drugs in treatment of hypertension.Methods:One hundred and twenty patients with hypertension were randomly divided into the control and the observation groups,60 cases in each group.The patients in observation group were received comprehensive intervention combined with drugs while the patients in control group were given with drug only.The changes of systolic and diastolic blood pressure before and after treatment and clinical efficacy were compared between the two groups.Results:After treatment,diastolic and systolic blood pressure were decreased significantly compared with before in both groups(P0.01),and in observation group,diastolic and systolic blood pressure were decreased significantly than in control group(P0.01);the total effective rate in observation group was 95%,which was significantly higher than 80% in control group(P0.05).Conclusions:The combination of comprehensive interventions and drugs for hypertension patients may be more effective in reducing blood pressure,improving clinical efficacy,and it can eliminate or reduce the health risk factors and improve the quality of life.
Objective:To investigate the efficacy of comprehensive interventions combined with drugs in treatment of hypertension.Methods:One hundred and twenty patients with hypertension were randomly divided into the control and the observation groups,60 cases in each group.The patients in observation group were received comprehensive intervention combined with drugs while the patients in control group were given with drug only.The changes of systolic and diastolic blood pressure before and after treatment and clinical efficacy were compared between the two groups.Results:After treatment,diastolic and systolic blood pressure were decreased significantly compared with before in both groups(P0.01),and in observation group,diastolic and systolic blood pressure were decreased significantly than in control group(P0.01);the total effective rate in observation group was 95%,which was significantly higher than 80% in control group(P0.05).Conclusions:The combination of comprehensive interventions and drugs for hypertension patients may be more effective in reducing blood pressure,improving clinical efficacy,and it can eliminate or reduce the health risk factors and improve the quality of life.
2012, 36(6): 674-675.
Abstract:
Objective:To investigate the pathological diagnostic value of gastrointestinal biopsy on high-grade intraepithelial neoplasia(HIN).Methods:A retrospective analysis of clinical and pathological information was done in 52 cases who were diagnosed as HIN by endoscopic biopsy,and the pathological diagnostic results were compared.Results:In total HIN patients,27 cases were diagnosed as the scope of endoscopic lesion was 3 cm,including 18 cases whose lesion was in upper digestive tract,and 13 cases were diagnosed as cancer with postoperative pathological analysis;9 cases whose lesion was in colon and rectum,1 case was diagnosed as cancer.There was statistical difference in the two groups(P=0.004).The ratio of cancer in upper gastrointestinal tract in these two groups whose lesion range was 3 cm or 3 cm were compared,there was no difference in two groups which diagnosed cancer in upper gastroinfestfinal tract regardless of lesion ragne(P=1.000);but there was statistical difference in colorectal patients whose lesion range was 3 cm or 3 cm(P=0.002).Conclusions:It needs to choose an active treatment when preoperative endoscopic biopsy is diagnosed as HIN in upper digestive tract.The surgical operation needs to be prudent when lesion range is 3 cm in colorectal lesion.
Objective:To investigate the pathological diagnostic value of gastrointestinal biopsy on high-grade intraepithelial neoplasia(HIN).Methods:A retrospective analysis of clinical and pathological information was done in 52 cases who were diagnosed as HIN by endoscopic biopsy,and the pathological diagnostic results were compared.Results:In total HIN patients,27 cases were diagnosed as the scope of endoscopic lesion was 3 cm,including 18 cases whose lesion was in upper digestive tract,and 13 cases were diagnosed as cancer with postoperative pathological analysis;9 cases whose lesion was in colon and rectum,1 case was diagnosed as cancer.There was statistical difference in the two groups(P=0.004).The ratio of cancer in upper gastrointestinal tract in these two groups whose lesion range was 3 cm or 3 cm were compared,there was no difference in two groups which diagnosed cancer in upper gastroinfestfinal tract regardless of lesion ragne(P=1.000);but there was statistical difference in colorectal patients whose lesion range was 3 cm or 3 cm(P=0.002).Conclusions:It needs to choose an active treatment when preoperative endoscopic biopsy is diagnosed as HIN in upper digestive tract.The surgical operation needs to be prudent when lesion range is 3 cm in colorectal lesion.
2012, 36(6): 676-678.
Abstract:
Objective:To compare the clinical efficacy of glass fiber and cast metal post in repair of the maxillary anterior kesidual crown and root.Methods:One hundred and sixty cases(210 teeth) with requiring repair anterior teeth were randomly divided into group A(105 teeth),which were repaired with glass fiber post and group B(105 teeth),which were repaired with cast metal post and the porcelain for crown.After two-year following-up,the clinical efficacy were observed.Results:One hundred and forty-five cases(185 teeth) were followed and 15 cases failed to follow.For 95 teeth of 77 cases of group A,82 teeth recovered and 13 teeeth failed,and 69 teeth recovered and 21 teeeth failed in 90 teeth of 68 cases of group B.The clinical efficacy of two groups had no statistically significant difference(P0.05),the occurrence of root fracture,pile core break and pile core loose or fall off had statistical difference(P0.05),but no statistical difference in the occurrence of the crown mobility or fall off and gingival edge discoloration in two groups(P0.05).Conclusions:Glass fiber post for protecting root facture and fall off is better than cast metal post.
Objective:To compare the clinical efficacy of glass fiber and cast metal post in repair of the maxillary anterior kesidual crown and root.Methods:One hundred and sixty cases(210 teeth) with requiring repair anterior teeth were randomly divided into group A(105 teeth),which were repaired with glass fiber post and group B(105 teeth),which were repaired with cast metal post and the porcelain for crown.After two-year following-up,the clinical efficacy were observed.Results:One hundred and forty-five cases(185 teeth) were followed and 15 cases failed to follow.For 95 teeth of 77 cases of group A,82 teeth recovered and 13 teeeth failed,and 69 teeth recovered and 21 teeeth failed in 90 teeth of 68 cases of group B.The clinical efficacy of two groups had no statistically significant difference(P0.05),the occurrence of root fracture,pile core break and pile core loose or fall off had statistical difference(P0.05),but no statistical difference in the occurrence of the crown mobility or fall off and gingival edge discoloration in two groups(P0.05).Conclusions:Glass fiber post for protecting root facture and fall off is better than cast metal post.
2012, 36(6): 679-680.
Abstract:
Objective:To explore the effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage.Methods:Forty-two patients with cerebral hemorrhage were detected by transcranial Doppler and the mean flow velocities(MFV) and pulsatility index(PI) of bilateral middle cerebral arteries(MCA) were recorded before and after treatment with mannitol.Results:The MFV and PI of the affected side had no significant difference before and after treatment with mannitol(P0.05),the MPV of the normal side were lower than that of the affected side(P0.01),the data at 10 and 60 min after injecting mannitol were lower than that of before treatment.The PI of the normal side were higher than that of the affected side(P0.05 to P0.01),and the data at 10 and 60 min after injecting mannitol were higher than that of before treatment and which were higher at 10 min than that of at 60 min(P0.01).Conclusions:Mannitol can increase the MFV of the affected side and the PI of the normal side of patient with cerebral hemorrhage,and improve the blood perfusion around the affected brain tissue.
Objective:To explore the effects of mannitol on cerebral blood flow condition of patient with cerebral hemorrhage.Methods:Forty-two patients with cerebral hemorrhage were detected by transcranial Doppler and the mean flow velocities(MFV) and pulsatility index(PI) of bilateral middle cerebral arteries(MCA) were recorded before and after treatment with mannitol.Results:The MFV and PI of the affected side had no significant difference before and after treatment with mannitol(P0.05),the MPV of the normal side were lower than that of the affected side(P0.01),the data at 10 and 60 min after injecting mannitol were lower than that of before treatment.The PI of the normal side were higher than that of the affected side(P0.05 to P0.01),and the data at 10 and 60 min after injecting mannitol were higher than that of before treatment and which were higher at 10 min than that of at 60 min(P0.01).Conclusions:Mannitol can increase the MFV of the affected side and the PI of the normal side of patient with cerebral hemorrhage,and improve the blood perfusion around the affected brain tissue.
2012, 36(6): 681-683.
Abstract:
Objective:To investigate the effect of sevoflurane preconditioning on QT dispersion(QTd) and hemodynamical changes following carbon dioxide(CO2) pneumoperitoneum in hypertension patients.Methods:Sixty hypertension patients who received laparoscopic cholecystectomy were divided into sevoflurane pretreatment group(30 cases) and control group(30 cases) randomly.The QTd values,mean arterial pressure(MAP) and heart rate(HR) were recorded in pre-induction(T0),before pneumoperitoneum(T1),and immediately(T2),at 5 min(T3),at 10 min(T4) after pneumoperitoneum.Results:In pretreatment group,MAP,HR and QTd value at T2,T3 and T4 were lower than those in control group(P0.05 to P0.01).Conclusions:Sevoflurane preconditioning can shorten QTd value and stabilize hemodynamical changes after CO2 pneumoperitoneum in hypertension patients.
Objective:To investigate the effect of sevoflurane preconditioning on QT dispersion(QTd) and hemodynamical changes following carbon dioxide(CO2) pneumoperitoneum in hypertension patients.Methods:Sixty hypertension patients who received laparoscopic cholecystectomy were divided into sevoflurane pretreatment group(30 cases) and control group(30 cases) randomly.The QTd values,mean arterial pressure(MAP) and heart rate(HR) were recorded in pre-induction(T0),before pneumoperitoneum(T1),and immediately(T2),at 5 min(T3),at 10 min(T4) after pneumoperitoneum.Results:In pretreatment group,MAP,HR and QTd value at T2,T3 and T4 were lower than those in control group(P0.05 to P0.01).Conclusions:Sevoflurane preconditioning can shorten QTd value and stabilize hemodynamical changes after CO2 pneumoperitoneum in hypertension patients.
2012, 36(6): 684-686.
Abstract:
Objective:To detect the protein expressions of HK6 and B7-H4 in tissue and serum of normal ovary,benign ovarian disease and ovarian cancer,and explore the clinical diagnostic significance of HK6 and B7-H4.Methods:Immunohistochemical SPmethod and ELSIA were used in detecting HK6 and B7-H4 expressions in ovarian tissue and serum,and the correlation between serum concentrations of HK6 and B7-H4 expressions in ovarian tissue were analyzed combined with clinical data on 28 ovarian cancer patients.Results:HK6 was expressed positively in ovarian caricinoma,while B7-H4 was expressed negatively in mucinous carcinomas.HK6 and B7-H4 were present at low level in serum of healthy controls and benign ovarian disease patients,but expressed at high levelin serum from ovarian cancer patients.There was significant correlation between the expressions of the two proteins in ovarian cancer(P0.01).Conclusions:HK6 and B7-H4 in ovarian cancer tissue and serum are highly expressed,it can guide for diagnosis of ovarian cancer that detection of combined with the two proteins.
Objective:To detect the protein expressions of HK6 and B7-H4 in tissue and serum of normal ovary,benign ovarian disease and ovarian cancer,and explore the clinical diagnostic significance of HK6 and B7-H4.Methods:Immunohistochemical SPmethod and ELSIA were used in detecting HK6 and B7-H4 expressions in ovarian tissue and serum,and the correlation between serum concentrations of HK6 and B7-H4 expressions in ovarian tissue were analyzed combined with clinical data on 28 ovarian cancer patients.Results:HK6 was expressed positively in ovarian caricinoma,while B7-H4 was expressed negatively in mucinous carcinomas.HK6 and B7-H4 were present at low level in serum of healthy controls and benign ovarian disease patients,but expressed at high levelin serum from ovarian cancer patients.There was significant correlation between the expressions of the two proteins in ovarian cancer(P0.01).Conclusions:HK6 and B7-H4 in ovarian cancer tissue and serum are highly expressed,it can guide for diagnosis of ovarian cancer that detection of combined with the two proteins.
2012, 36(6): 687-689.
Abstract:
Objective:To observe the effects of wenxinkeli on the arrhythmia of acute coronary syndrome(ACS) and angiotensin Ⅱ(AngⅡ).Methods:Fifty-five cases with ACS were randomly divided into control group(27 cases) which were treated with conventional medication and treatment group(28 cases) which were treated with conventional medication added to wenxinkeli by oral.The arrhythmia and plasma AngⅡof two groups were observed.Results:The arrhythmia of the treatment group were less than that of the control group(P0.05).The plasma concentration of AngⅡ and N-terminal prohormone of brain natriuretic peptide of two groups had no significant difference at 2 weeks after treatment with wenxinkeli(P0.05).The mortality of two groups had no obviouse difference after 6 months(P0.05).Conclusions:Wenxinkeli can treat arrhythmia,prevent serious arrhythmia and no side-effects in the patients with ACS,which has no influence on plasma AngⅡafter 2 weeks.
Objective:To observe the effects of wenxinkeli on the arrhythmia of acute coronary syndrome(ACS) and angiotensin Ⅱ(AngⅡ).Methods:Fifty-five cases with ACS were randomly divided into control group(27 cases) which were treated with conventional medication and treatment group(28 cases) which were treated with conventional medication added to wenxinkeli by oral.The arrhythmia and plasma AngⅡof two groups were observed.Results:The arrhythmia of the treatment group were less than that of the control group(P0.05).The plasma concentration of AngⅡ and N-terminal prohormone of brain natriuretic peptide of two groups had no significant difference at 2 weeks after treatment with wenxinkeli(P0.05).The mortality of two groups had no obviouse difference after 6 months(P0.05).Conclusions:Wenxinkeli can treat arrhythmia,prevent serious arrhythmia and no side-effects in the patients with ACS,which has no influence on plasma AngⅡafter 2 weeks.
2012, 36(6): 690-692.
Abstract:
Objective:To investigate the correlation of serum markers and liver fibrosis pathological stage in patients with chronic hepatitis B.Methods:The routine pathological examination of liver biopsy was tested in 214 cases of hepatitis B patients,the serum markers of liver fibrosis and liver function parameters,blood coagulation index and HBV-DNA level were also measured.The correlation of the test items and liver fibrosis stage was discussed.Results:There were statistical differences about hyaluronic acid,laminin,Ⅳ collagen,Ⅲ procollagen and other 10 test items with pathological stages of liver fibrosis(P0.01).Conclusions:Hyaluronic acid,laminin,collagen Ⅳ,collagen Ⅲ and other serum test could be effective in diagnosis of hepatitis B patients with liver fibrosis,and they can predict the trend of liver fibrosis.
Objective:To investigate the correlation of serum markers and liver fibrosis pathological stage in patients with chronic hepatitis B.Methods:The routine pathological examination of liver biopsy was tested in 214 cases of hepatitis B patients,the serum markers of liver fibrosis and liver function parameters,blood coagulation index and HBV-DNA level were also measured.The correlation of the test items and liver fibrosis stage was discussed.Results:There were statistical differences about hyaluronic acid,laminin,Ⅳ collagen,Ⅲ procollagen and other 10 test items with pathological stages of liver fibrosis(P0.01).Conclusions:Hyaluronic acid,laminin,collagen Ⅳ,collagen Ⅲ and other serum test could be effective in diagnosis of hepatitis B patients with liver fibrosis,and they can predict the trend of liver fibrosis.
2012, 36(6): 693-695.
Abstract:
Objective:To explore the clinical value of 64 row helical CT in the follow-up of coronary artery bypass grafting.Methods:Twenty-seven cases with coronary artery bypass grafting(CABG) were examined,revascularizated and angiographied with 64 row helical CT,and the grafts imaging were analyzed.Results:Twenty-seven cases were treated with 79 arteries blood vessels bridge,and images ofall grafts were obtained by using coronary angiography,which included 24 internal mammary grafts,52 saphenous vein grafts and 3 radial artery grafts.The bridge hemal stricture rates were 25.0% in internal mammary grafts,57.7% in saphenous vein grafts and 66.7% in radial artery grafts under 64 row helical CT,which had no statistical significance(P0.05) compared with coronaryangiography.The false positive and negative rates of 64 row helical CT were 8.6% and 2.3% respectively.Conclusions:Sixty-four row helical CT is a safe,fast and non-invasive diagnostic method,which is a ideal method for follow up coronary artery bypass grafting.
Objective:To explore the clinical value of 64 row helical CT in the follow-up of coronary artery bypass grafting.Methods:Twenty-seven cases with coronary artery bypass grafting(CABG) were examined,revascularizated and angiographied with 64 row helical CT,and the grafts imaging were analyzed.Results:Twenty-seven cases were treated with 79 arteries blood vessels bridge,and images ofall grafts were obtained by using coronary angiography,which included 24 internal mammary grafts,52 saphenous vein grafts and 3 radial artery grafts.The bridge hemal stricture rates were 25.0% in internal mammary grafts,57.7% in saphenous vein grafts and 66.7% in radial artery grafts under 64 row helical CT,which had no statistical significance(P0.05) compared with coronaryangiography.The false positive and negative rates of 64 row helical CT were 8.6% and 2.3% respectively.Conclusions:Sixty-four row helical CT is a safe,fast and non-invasive diagnostic method,which is a ideal method for follow up coronary artery bypass grafting.
2012, 36(6): 696-698.
Abstract:
Objective:To study the effect of simvastatin combined with aspirin on recurrence of cerebral infarction with carotid atherosclerosis.Methods:Sixty two cerebral infarction cases associated with carotid atherosclerosis were randomly divided into two groups after discharged,the patients in treatment group were given oral aspirin and simvastatin,and others in control group were given oral aspirin only,at the same time,all cases in both groups were taken blood-activating and stasis-dissolving drugs.The recurrence of cerebral infarction and incidence of adverse reactions within 2 years were analyzed between the two groups.Results:The recurrence rate of cerebral infarction in treatment group(6.25%) and in control group(30.00%) was significantly different(P0.05),and there was no statistical difference about gastrointestinal tract and liver side effects.Two years after discharged,there were statistical differences about blood lipid of levels,area of carotid arterial plaque and intima media thickness between the two groups(P0.01).Conclusions:Simvastatin combined with aspirin presents plays the exact clinical effect on prevention recurrence of cerebral infarction with carotid atherosclerosis,and this combination do not increase the incidence of adverse reactions.
Objective:To study the effect of simvastatin combined with aspirin on recurrence of cerebral infarction with carotid atherosclerosis.Methods:Sixty two cerebral infarction cases associated with carotid atherosclerosis were randomly divided into two groups after discharged,the patients in treatment group were given oral aspirin and simvastatin,and others in control group were given oral aspirin only,at the same time,all cases in both groups were taken blood-activating and stasis-dissolving drugs.The recurrence of cerebral infarction and incidence of adverse reactions within 2 years were analyzed between the two groups.Results:The recurrence rate of cerebral infarction in treatment group(6.25%) and in control group(30.00%) was significantly different(P0.05),and there was no statistical difference about gastrointestinal tract and liver side effects.Two years after discharged,there were statistical differences about blood lipid of levels,area of carotid arterial plaque and intima media thickness between the two groups(P0.01).Conclusions:Simvastatin combined with aspirin presents plays the exact clinical effect on prevention recurrence of cerebral infarction with carotid atherosclerosis,and this combination do not increase the incidence of adverse reactions.
2012, 36(6): 699-701.
Abstract:
Objective:To investigate the clinical efficacy of prednisone combined with oral anti-thyroid drugs and simple oral anti-thyroid drugs for treating Graves' disease.Methods:Seventy-four cases with Graves' disease were randomly divided into observation group,which were treated with prednisone and methimazole of oral anti-thyroid and control group,which were treated with methimazole(37 cases in each group).All cases were followed up for 1 year,and the clinical efficacy,thyroid hormone levels,related immune indicators,toxicity and complications of two groups were analysed.Results:The 91.89% of clinical efficacy of the observation group was significantly higher than 70.27% of the control group(P0.05).Compared with the pre-treatment,the decreasing FT3,FT4,IgG and IgM levels and the increasing thyroid stimulating hormone levels were observed after treatment,and there were significant differences between the two groups(P0.01).There were 13.51% of side effects and 10.81% of complications of the observation group were significantly lower than 37.84% and 32.43% of the control group respectively(P0.05).Conclusions:The efficacy of prednisone combined with oral anti-thyroid drugs for treating Graves' disease is better than that of oral anti-thyroid drugs only,which can significantly improve the clinical efficacy,thyroid hormone levels,immune parameters and reduce toxicity,so as to be worth spreading.
Objective:To investigate the clinical efficacy of prednisone combined with oral anti-thyroid drugs and simple oral anti-thyroid drugs for treating Graves' disease.Methods:Seventy-four cases with Graves' disease were randomly divided into observation group,which were treated with prednisone and methimazole of oral anti-thyroid and control group,which were treated with methimazole(37 cases in each group).All cases were followed up for 1 year,and the clinical efficacy,thyroid hormone levels,related immune indicators,toxicity and complications of two groups were analysed.Results:The 91.89% of clinical efficacy of the observation group was significantly higher than 70.27% of the control group(P0.05).Compared with the pre-treatment,the decreasing FT3,FT4,IgG and IgM levels and the increasing thyroid stimulating hormone levels were observed after treatment,and there were significant differences between the two groups(P0.01).There were 13.51% of side effects and 10.81% of complications of the observation group were significantly lower than 37.84% and 32.43% of the control group respectively(P0.05).Conclusions:The efficacy of prednisone combined with oral anti-thyroid drugs for treating Graves' disease is better than that of oral anti-thyroid drugs only,which can significantly improve the clinical efficacy,thyroid hormone levels,immune parameters and reduce toxicity,so as to be worth spreading.
2012, 36(6): 702-703.
Abstract:
Objective:To observe the clinical effects and safety of application of etomidate combined with propofol in gastroscopy for elderly patients.Methods:Two hundred gastroscope inspection cases were randomly divided into group A and group B(100 cases in each group).The cases of group A were injected with 0.04 mg of fentanyl and 1.5 mg/kg of propofol.The cases of group B were injected with 0.04 mg of fentanyl and 0.8 mg/kg of propofol.After a few seconds,0.2 mg/kg of etomidate was added if necessary,0.5 mg/kg of propofol was given again.Blood pressure,heart rate,SpO2 and respiratory amplitude and frequency,gastral peristalsis,amyostasia and reverse flow nausea of all cases were recorded before and after anesthesia.Results:Both groups successfully completed gastroscope inspection.Various indexes of respiratory and circulation of all cases were not statistically significant(P0.05) before and after anesthesia.The MAP and SpO2 of group A after anesthesia significantly decreased than that of group A before anesthesia and group B(P0.01).The occurrences of amyostasia and reverse flow nausea of two groups were not significant different(P0.05).Conclusions:Etomidate combined with propofol in gastroscopy can significantly decrease the occurrences of espiratory and circulation suppressor,amyostasia and reverse flow nausea and Increase asafety.Awakening time of two groups have no significant difference.The application of propofol combineded with etomidate in gastroscopy for elderly patients is of certain clinical value.
Objective:To observe the clinical effects and safety of application of etomidate combined with propofol in gastroscopy for elderly patients.Methods:Two hundred gastroscope inspection cases were randomly divided into group A and group B(100 cases in each group).The cases of group A were injected with 0.04 mg of fentanyl and 1.5 mg/kg of propofol.The cases of group B were injected with 0.04 mg of fentanyl and 0.8 mg/kg of propofol.After a few seconds,0.2 mg/kg of etomidate was added if necessary,0.5 mg/kg of propofol was given again.Blood pressure,heart rate,SpO2 and respiratory amplitude and frequency,gastral peristalsis,amyostasia and reverse flow nausea of all cases were recorded before and after anesthesia.Results:Both groups successfully completed gastroscope inspection.Various indexes of respiratory and circulation of all cases were not statistically significant(P0.05) before and after anesthesia.The MAP and SpO2 of group A after anesthesia significantly decreased than that of group A before anesthesia and group B(P0.01).The occurrences of amyostasia and reverse flow nausea of two groups were not significant different(P0.05).Conclusions:Etomidate combined with propofol in gastroscopy can significantly decrease the occurrences of espiratory and circulation suppressor,amyostasia and reverse flow nausea and Increase asafety.Awakening time of two groups have no significant difference.The application of propofol combineded with etomidate in gastroscopy for elderly patients is of certain clinical value.
2012, 36(6): 706-707.
Abstract:
Objective:To explore the clinical value of two-dimensional and color Doppler ultrasonography in the diagnosis of thyroid Carcinoma.Methods:Forty-two cases with thyroid carcinoma were confirmed by pathological examination.The size of the thyroid,echo,mass's size,shape,position,number,internal echo intensity and evenness,the calcification changes,the blood distributioncolor and the resistance index of blood of all cases were measured.Results:In all patients,the lumps of 32 cases were abnormity,the heterogeneous echo of lumps of 34 cases were low,28 cases had small calcification,37 cases had abundant blood flow and the resistance index of blood of 30 cases were less than 0.7.Conclusions:The performances of ultrasonography of thyroid carcinoma have definite features.It has important clinical value to diagnose thyroid carcinoma.
Objective:To explore the clinical value of two-dimensional and color Doppler ultrasonography in the diagnosis of thyroid Carcinoma.Methods:Forty-two cases with thyroid carcinoma were confirmed by pathological examination.The size of the thyroid,echo,mass's size,shape,position,number,internal echo intensity and evenness,the calcification changes,the blood distributioncolor and the resistance index of blood of all cases were measured.Results:In all patients,the lumps of 32 cases were abnormity,the heterogeneous echo of lumps of 34 cases were low,28 cases had small calcification,37 cases had abundant blood flow and the resistance index of blood of 30 cases were less than 0.7.Conclusions:The performances of ultrasonography of thyroid carcinoma have definite features.It has important clinical value to diagnose thyroid carcinoma.
2012, 36(6): 708-709.
Abstract:
Objective:To explore the guideline effects of MRI with low electric field intensity on operation of knee joints.Methods:The MRI results of 63 cases with injury knee verified through operation or arthroscopes pathology were retrospectively analyzed.Results:In 48 cases with meniscus injury,MRI showed that there were abnormal linar,strip and star shape hyperintense in meniscus.In 21 cases with anterior cruciate ligaments injury,8 cases with the posterior cruciate ligament injury and 9 cases with collateral ligaments injury,MRI showed that the ligaments continuity were injury and tearing and abnormal linar and strip sign existed inside of ligament.In 49 cases with knee joint effusion,MRI showed that high T2 weighted images(T2WI) and low T1 weighted images signal appeared in cavity of joints.In 19 cases with hiding bone fracture,the linar and strip high T2WI signal of MRI were detected in sclerotin.Conclusions:The results of MRI with low electric intensity for injured knee joints have guideline value for clinical operation.
Objective:To explore the guideline effects of MRI with low electric field intensity on operation of knee joints.Methods:The MRI results of 63 cases with injury knee verified through operation or arthroscopes pathology were retrospectively analyzed.Results:In 48 cases with meniscus injury,MRI showed that there were abnormal linar,strip and star shape hyperintense in meniscus.In 21 cases with anterior cruciate ligaments injury,8 cases with the posterior cruciate ligament injury and 9 cases with collateral ligaments injury,MRI showed that the ligaments continuity were injury and tearing and abnormal linar and strip sign existed inside of ligament.In 49 cases with knee joint effusion,MRI showed that high T2 weighted images(T2WI) and low T1 weighted images signal appeared in cavity of joints.In 19 cases with hiding bone fracture,the linar and strip high T2WI signal of MRI were detected in sclerotin.Conclusions:The results of MRI with low electric intensity for injured knee joints have guideline value for clinical operation.
2012, 36(6): 710-712.
Abstract:
Objective:To explore the association of the coping style with the personality and social support in medical college students.Methods:The 472 medical college students were surveyed by EPQ-RSC,social support scale and questionnaires about their coping style.The influence of personality and social support on the students' coping style was analyzed.Results:The male students got a higher score in rationalization than the female student(P0.01),while the female students got a higher self-accusation and illusion than the male student(P0.01 and P0.05);the rationalization and illusion scores were higher in students from the rural areas than those from the urban areas P0.01);personality and social support were closely related with the coping style of the students.The structural equation modeling fitted the data very well(2/df=4.16,P0.01,GFI=0.967,AGFI=0.935,NFI=0.949,CFI=0.930,RMSEA=0.069).Conclusions:Social supports and personality have direct influence on the coping style of medical college students,and the theoretical model supposes are strongly supported by the structural equation modeling.
Objective:To explore the association of the coping style with the personality and social support in medical college students.Methods:The 472 medical college students were surveyed by EPQ-RSC,social support scale and questionnaires about their coping style.The influence of personality and social support on the students' coping style was analyzed.Results:The male students got a higher score in rationalization than the female student(P0.01),while the female students got a higher self-accusation and illusion than the male student(P0.01 and P0.05);the rationalization and illusion scores were higher in students from the rural areas than those from the urban areas P0.01);personality and social support were closely related with the coping style of the students.The structural equation modeling fitted the data very well(2/df=4.16,P0.01,GFI=0.967,AGFI=0.935,NFI=0.949,CFI=0.930,RMSEA=0.069).Conclusions:Social supports and personality have direct influence on the coping style of medical college students,and the theoretical model supposes are strongly supported by the structural equation modeling.
2012, 36(6): 713-716.
Abstract:
Objective:To investigate the sexual health knowledge and sexual-related behavior of college students in Anhui and Sichuan.Methods:The sexual health knowledge scale and sexual-related behavior questionnaires were used.All data were analyzed by SPSS16.0.Results:The results revealed that college students in the two regions were quitely lack of sexual health knowledge,and the sexual health knowledge level of female college students was significantly lower than that of male college students.Sexual-related behavior active showed diversity trends,male students had significantly more sexual activities than women,including homosexual communication,forced sexual intercourse and so on.Conclusions:It suggested that Chinese college students need sex education urgently,especially sexual health knowledge education for female students,sexual health behavior education for male students.Besides,sexual and gender diversity,gender education,sexuality and law,and sexuality and sociality education should also be concerned.
Objective:To investigate the sexual health knowledge and sexual-related behavior of college students in Anhui and Sichuan.Methods:The sexual health knowledge scale and sexual-related behavior questionnaires were used.All data were analyzed by SPSS16.0.Results:The results revealed that college students in the two regions were quitely lack of sexual health knowledge,and the sexual health knowledge level of female college students was significantly lower than that of male college students.Sexual-related behavior active showed diversity trends,male students had significantly more sexual activities than women,including homosexual communication,forced sexual intercourse and so on.Conclusions:It suggested that Chinese college students need sex education urgently,especially sexual health knowledge education for female students,sexual health behavior education for male students.Besides,sexual and gender diversity,gender education,sexuality and law,and sexuality and sociality education should also be concerned.
2012, 36(6): 717-718.
Abstract:
Objective:To investigate the athletic injuries in university students taking wheel sports,and to provide the preventive measures.Methods:The questionnaire,literature and statistics methods were employed to research into the injuries of university students taking wheel sports in Bengbu Medical College.Results:Athletic injuries were frequently seen in students taking wheel sports.The occurrence of injuries on the knee,hips and wrists accounted for 42%,28% and 8%,respectively;the types of injury were mainly contusions and bruises,and the injuries were mostly of light and moderate degree;the rate of fracture was 4%.Conclusions:The main reasons for the athletic injuries include insufficient attention or preparation,and lack of skills.The injuries occur mostly in extracurricular time,especially in the evening.
Objective:To investigate the athletic injuries in university students taking wheel sports,and to provide the preventive measures.Methods:The questionnaire,literature and statistics methods were employed to research into the injuries of university students taking wheel sports in Bengbu Medical College.Results:Athletic injuries were frequently seen in students taking wheel sports.The occurrence of injuries on the knee,hips and wrists accounted for 42%,28% and 8%,respectively;the types of injury were mainly contusions and bruises,and the injuries were mostly of light and moderate degree;the rate of fracture was 4%.Conclusions:The main reasons for the athletic injuries include insufficient attention or preparation,and lack of skills.The injuries occur mostly in extracurricular time,especially in the evening.
2012, 36(6): 719-721.
Abstract:
Objective:To study the risk factors of injuries among university students in Bengbu and provide a basis of formulating effective intervening measures.Methods:One thousand eight hundred and fifty-six university students from three universitise in Bengbu were selected using stratified cluster sampling method on a basis of sex,age,grade,nation and areas,242 cases and 242 controls were studied according to 1∶ 1 matching principle,and data were analyzed by single factor and multivariate logistic regression analysis.Results:The incidence rate of injury was 13.49%.The results of single factor and multivariate logistic regression analysis demonstrated that no league activities and high nervous latitude score were risk factors.Two-parent family,higher education level of mother,safety of education and low latitude stability score were protective factors.Conclusions:The injuries in college students were caused by multiple factors.Enhancing safety education and improvement prevention and protection of consciousness of college students can control the occurrence of injury.
Objective:To study the risk factors of injuries among university students in Bengbu and provide a basis of formulating effective intervening measures.Methods:One thousand eight hundred and fifty-six university students from three universitise in Bengbu were selected using stratified cluster sampling method on a basis of sex,age,grade,nation and areas,242 cases and 242 controls were studied according to 1∶ 1 matching principle,and data were analyzed by single factor and multivariate logistic regression analysis.Results:The incidence rate of injury was 13.49%.The results of single factor and multivariate logistic regression analysis demonstrated that no league activities and high nervous latitude score were risk factors.Two-parent family,higher education level of mother,safety of education and low latitude stability score were protective factors.Conclusions:The injuries in college students were caused by multiple factors.Enhancing safety education and improvement prevention and protection of consciousness of college students can control the occurrence of injury.
2012, 36(6): 722-724.
Abstract:
Objective:To provide basis for clinical nutrition support treatment through understanding the nutritional status and nutrition support of aged hospitalized patients in secondary hospital.Methods:The nutrition risk screening(NRS) and nutrition index including serum albumin,body mass index of 1 261 aged patients were measured through screening method NRS2002.Results:NRS relevance rate was 73.6%,NRS score 3 ocurred in 420 patients,nutrition support was applied in 58 cases;in 1 261 cases,malnutrition occurred in 627 cases,including inadequate nutrition 324 cases,overweight 232 cases,and obesity 71 cases.Conclusions:The malnutrition incidence rate of aged patients in secondary hospital is high,nutrition support and related intervention is insufficient,nutrition support intervention should be applied early.
Objective:To provide basis for clinical nutrition support treatment through understanding the nutritional status and nutrition support of aged hospitalized patients in secondary hospital.Methods:The nutrition risk screening(NRS) and nutrition index including serum albumin,body mass index of 1 261 aged patients were measured through screening method NRS2002.Results:NRS relevance rate was 73.6%,NRS score 3 ocurred in 420 patients,nutrition support was applied in 58 cases;in 1 261 cases,malnutrition occurred in 627 cases,including inadequate nutrition 324 cases,overweight 232 cases,and obesity 71 cases.Conclusions:The malnutrition incidence rate of aged patients in secondary hospital is high,nutrition support and related intervention is insufficient,nutrition support intervention should be applied early.
2012, 36(6): 725-726.
Abstract:
Objective:To optimize the extraction process of paeonol by steam distillation.Methods:Referring to the content of paeonol,an orthogonal design table L9(34) was used with the factors of extraction time,water-adding amount,medicinal size and salt content.Results:The optimal process of extraction was as follows:the granularity of paeonia suffruticosa andr was (0.20.05)cm,adding 6 times amount of water,adding 1% sodium,the extraction time was 3 h.Conclusions:Experiments show that this method is effective to improve the extraction process of Paeonol.
Objective:To optimize the extraction process of paeonol by steam distillation.Methods:Referring to the content of paeonol,an orthogonal design table L9(34) was used with the factors of extraction time,water-adding amount,medicinal size and salt content.Results:The optimal process of extraction was as follows:the granularity of paeonia suffruticosa andr was (0.20.05)cm,adding 6 times amount of water,adding 1% sodium,the extraction time was 3 h.Conclusions:Experiments show that this method is effective to improve the extraction process of Paeonol.
2012, 36(6): 727-729.
Abstract:
Objective:To improve bone formation by mineralizing silk fibroin scaffold with calcium phosphate.Methods:Silk fibroin was immerged into calcium phosphate solution,and then mineralized on its surface using hydrothermal method.The characteristics of silk fibroin surface-modified were measured by scanning electron microscopy(SEM),energy dispersive X-ray microanalysis,X-ray diffraction and Fourier transform infrared spectroscopy.Results:SEM indicated that the surface of silk fibroin was mostly coated by calcium phosphate.The patterns of silk fibroin surface-modified were not changed after immerging in solution,and carbonate apatite distributed on its surface.Conclusions:As a natural material,the silk fibroin possesses good biocompatibility.Silk fibroin/ CaP composite as scaffold material is a promising biomaterial.
Objective:To improve bone formation by mineralizing silk fibroin scaffold with calcium phosphate.Methods:Silk fibroin was immerged into calcium phosphate solution,and then mineralized on its surface using hydrothermal method.The characteristics of silk fibroin surface-modified were measured by scanning electron microscopy(SEM),energy dispersive X-ray microanalysis,X-ray diffraction and Fourier transform infrared spectroscopy.Results:SEM indicated that the surface of silk fibroin was mostly coated by calcium phosphate.The patterns of silk fibroin surface-modified were not changed after immerging in solution,and carbonate apatite distributed on its surface.Conclusions:As a natural material,the silk fibroin possesses good biocompatibility.Silk fibroin/ CaP composite as scaffold material is a promising biomaterial.
2012, 36(6): 730-731.
Abstract:
Objective:To study the effects of the clinical nursing pathway on the patients with chronic obstructive pulmonary disease(COPD).Methods:Seventy-eight cases were randomly divided into the experimental group,which was treated with clinical nursing pathway and the control group,which was treated with traditional nursing methods.The hospital stays,hospitalization expenses,understanding of health knowledge and degree of satisfaction of all cases were analysed.Results:The hospital stays and hospitalization expenses of the experimental group were significantly lower than that of the control group(P0.01),and the degree of satisfaction and the extent of understanding of health knowledge of the experimental group were significantly better than those of the control group(P0.01).Conclusions:The application of clinical nursing pathway for the patients with COPD,can improve the quality of nursing and the relationship between the nurses and the patients,and promote rehabilitation.
Objective:To study the effects of the clinical nursing pathway on the patients with chronic obstructive pulmonary disease(COPD).Methods:Seventy-eight cases were randomly divided into the experimental group,which was treated with clinical nursing pathway and the control group,which was treated with traditional nursing methods.The hospital stays,hospitalization expenses,understanding of health knowledge and degree of satisfaction of all cases were analysed.Results:The hospital stays and hospitalization expenses of the experimental group were significantly lower than that of the control group(P0.01),and the degree of satisfaction and the extent of understanding of health knowledge of the experimental group were significantly better than those of the control group(P0.01).Conclusions:The application of clinical nursing pathway for the patients with COPD,can improve the quality of nursing and the relationship between the nurses and the patients,and promote rehabilitation.
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