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2014 Vol. 39, No. 1
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2014, 38(1): 3-6.
Abstract:
Objective:To investigate the methodology of pathological partition,boundary segmentation,3D-reconstruction and visualization with multi-voxel proton MR spectroscopy (1H-MRS) in human brain gliomas for clinical application.Methods:Five patients with brain gliomas underwent T1WI,T2WI,contrast enhanced MRI and 1H-MRS before the operation.And the results were compared with pathological results,according to a variety of metabolites levels grade gliomas and part glioma and surrounding brain tissue.Select one case of glioma scanned data of Dicom3.0 format import 3D-Doctor software,artificial divide tumor area,necrosis,edema,brain surface,were marked with different colors,in complex surface reconstruction method three-dimensional reconstructe structure of the above simultaneously.Results:Using 1H-MRS for glioma tumor and surrounding area were largely partitioned and in preoperative classification of benign and malignant tumors were consistent with pathological results.Successful reconstructe of the tumor and surrounding brain tissue three-dimensional visualization model of the entire brain,could be rotated in any orientation,the model from different angles reproduce the three-dimensional shape and spatial location of the tumor in the brain and the positional relationship.Conclusions:Brain tumors using 1H-MRS of Cho/Cr,NAA/Cr,NAA/Cho metabolite ratios in combination with conventional MRI in the diagnosis of brain tumors and non-invasive glioma grade and part is feasible.The gliomas three-dimensional visualization model reconstruction,the model from different angles reproduce the three-dimensional shape and spatial location of the tumor in the brain and the positional relationship,for reconstruction and observation of brain lesions provides an important approach.Surgical approach to the development of stereotactic surgery,interventional radiology and radiation treatment planning to develop medical education has great value.
Objective:To investigate the methodology of pathological partition,boundary segmentation,3D-reconstruction and visualization with multi-voxel proton MR spectroscopy (1H-MRS) in human brain gliomas for clinical application.Methods:Five patients with brain gliomas underwent T1WI,T2WI,contrast enhanced MRI and 1H-MRS before the operation.And the results were compared with pathological results,according to a variety of metabolites levels grade gliomas and part glioma and surrounding brain tissue.Select one case of glioma scanned data of Dicom3.0 format import 3D-Doctor software,artificial divide tumor area,necrosis,edema,brain surface,were marked with different colors,in complex surface reconstruction method three-dimensional reconstructe structure of the above simultaneously.Results:Using 1H-MRS for glioma tumor and surrounding area were largely partitioned and in preoperative classification of benign and malignant tumors were consistent with pathological results.Successful reconstructe of the tumor and surrounding brain tissue three-dimensional visualization model of the entire brain,could be rotated in any orientation,the model from different angles reproduce the three-dimensional shape and spatial location of the tumor in the brain and the positional relationship.Conclusions:Brain tumors using 1H-MRS of Cho/Cr,NAA/Cr,NAA/Cho metabolite ratios in combination with conventional MRI in the diagnosis of brain tumors and non-invasive glioma grade and part is feasible.The gliomas three-dimensional visualization model reconstruction,the model from different angles reproduce the three-dimensional shape and spatial location of the tumor in the brain and the positional relationship,for reconstruction and observation of brain lesions provides an important approach.Surgical approach to the development of stereotactic surgery,interventional radiology and radiation treatment planning to develop medical education has great value.
2014, 38(1): 7-10.
Abstract:
Objective:To explore the morphology rule of cerebral superior temporal sulucs(STS) on the MRI cross section and the sagittal plane image of brain.Methods:In the eFilm2.1 workstation,29 normal adult volunteer head continuously MRI scanning data which will gain,uses the continuous tracking method and the 3D-Cursor technology,STS carries on the recognition,the observation to continuously on the MRI cross section and the sagittal plane image,to count its morphological character.Results:The STS may appear in Z =-36-48 mm on the sector MRI cross fault image(95% distributes in the Z =-30-42 mm stratification plane),and after the stratification plane uppers shift the sulci move backward.STS can be divided into anterior horizontal part and posterior ascending part in the sagittal plane.In the Z =-6-6 mm stratification plane STS can assume the big obtuse angle backward obviously the inflection point; STS may present the multi-ditch performance in the Z =-21-12 mm cross section(95% to distribute in the Z =-18-9 mm stratification plane).Conclusions:This article result may help STS fast recognition and around the ditch the important structure accurate localization.
Objective:To explore the morphology rule of cerebral superior temporal sulucs(STS) on the MRI cross section and the sagittal plane image of brain.Methods:In the eFilm2.1 workstation,29 normal adult volunteer head continuously MRI scanning data which will gain,uses the continuous tracking method and the 3D-Cursor technology,STS carries on the recognition,the observation to continuously on the MRI cross section and the sagittal plane image,to count its morphological character.Results:The STS may appear in Z =-36-48 mm on the sector MRI cross fault image(95% distributes in the Z =-30-42 mm stratification plane),and after the stratification plane uppers shift the sulci move backward.STS can be divided into anterior horizontal part and posterior ascending part in the sagittal plane.In the Z =-6-6 mm stratification plane STS can assume the big obtuse angle backward obviously the inflection point; STS may present the multi-ditch performance in the Z =-21-12 mm cross section(95% to distribute in the Z =-18-9 mm stratification plane).Conclusions:This article result may help STS fast recognition and around the ditch the important structure accurate localization.
2014, 38(1): 11-13.
Abstract:
Objective:To establish the three-dimensional visible model of sylvian fissure based on thin layer of MR images in Chinese adult living donor and provide the anatomic basis for clinic.Methods:The brain thin layer MR scanning in 5 healthy adult volunteers were implemented,the data were inputted to 3D-Doctor software package for establishing three-dimensional visible model of Sylvian fissure.Results:The three-dimensional visualization model of sylvian fissure was successfully constructed,which could clearly showed the three-dimensional form of sylvian fissure in brain and adjacent relationship of surrounding vital structures.The model could be rotated in any direction.Conclusions:This three-dimensional visible model of the sylvian fissure can provide morphological reference in clinical practice and the basis for virtual surgery.
Objective:To establish the three-dimensional visible model of sylvian fissure based on thin layer of MR images in Chinese adult living donor and provide the anatomic basis for clinic.Methods:The brain thin layer MR scanning in 5 healthy adult volunteers were implemented,the data were inputted to 3D-Doctor software package for establishing three-dimensional visible model of Sylvian fissure.Results:The three-dimensional visualization model of sylvian fissure was successfully constructed,which could clearly showed the three-dimensional form of sylvian fissure in brain and adjacent relationship of surrounding vital structures.The model could be rotated in any direction.Conclusions:This three-dimensional visible model of the sylvian fissure can provide morphological reference in clinical practice and the basis for virtual surgery.
2014, 38(1): 14-18.
Abstract:
Objective:To build the stereotactic data set and the planar regression equation of sulcus of the insula,based on the Descartes coordinate system which was set on the line between the anterior commissure and the posterior commissure.Methods:After the strict image registration,the coordinate system of the software coincides with the Descartes coordinate system based on AC-PC line were made.Then the coordinates of the central insular sulcus,the anterior periisular sulcus and the inferior periisular sulcus were recorded,the X-value and Y-value of the sample point was recorded directly from the software,the Z-value is the number of distance from recorded plane to the AC-PC plane.The stereotactic data set of the insular sulcus were constituted by all the coordinate values of sample points of insula,then the regression equations were fetched which were analysed by the SPSS13.0 software.Results:The threedimensional stereotactic data set and the regression equation of the insular sulcus were constructed successfully.Conclusions:The construction of the insular stereotactic data set could provide anatomic basis for the application of stereotactic and functional neurosurgery,three-dimensional radiotherapy,and simultaneously uncovered the significant rules of the development of basilar parts of the human brain.
Objective:To build the stereotactic data set and the planar regression equation of sulcus of the insula,based on the Descartes coordinate system which was set on the line between the anterior commissure and the posterior commissure.Methods:After the strict image registration,the coordinate system of the software coincides with the Descartes coordinate system based on AC-PC line were made.Then the coordinates of the central insular sulcus,the anterior periisular sulcus and the inferior periisular sulcus were recorded,the X-value and Y-value of the sample point was recorded directly from the software,the Z-value is the number of distance from recorded plane to the AC-PC plane.The stereotactic data set of the insular sulcus were constituted by all the coordinate values of sample points of insula,then the regression equations were fetched which were analysed by the SPSS13.0 software.Results:The threedimensional stereotactic data set and the regression equation of the insular sulcus were constructed successfully.Conclusions:The construction of the insular stereotactic data set could provide anatomic basis for the application of stereotactic and functional neurosurgery,three-dimensional radiotherapy,and simultaneously uncovered the significant rules of the development of basilar parts of the human brain.
2014, 38(1): 19-21.
Abstract:
Objective:To observe the projection of cingulate sulcus in 3 planes,analysis cingulate sulcus growth pattern; and calculate fitting curvilinear equations of cingulate sulcus on the sagittal plane,analyze cingulate sulcus of the degree of difference between individuals.Methods:To blot the inner data of cingulate sulcus,and get the projection by Excel; to get the fitting curvilinear equations of cingulate sulcus on the sagittal plane by SPSS 14.0.Results:We have gotten the two-dimensional projection and fitting curvilinear equations of inner surface of cingulate sulcus.Conclusions:The two-dimensional projection may reflect the effluence rule of the cingulate sulcus and cerebral; the location of cingulate sulcus is relative stabilize.
Objective:To observe the projection of cingulate sulcus in 3 planes,analysis cingulate sulcus growth pattern; and calculate fitting curvilinear equations of cingulate sulcus on the sagittal plane,analyze cingulate sulcus of the degree of difference between individuals.Methods:To blot the inner data of cingulate sulcus,and get the projection by Excel; to get the fitting curvilinear equations of cingulate sulcus on the sagittal plane by SPSS 14.0.Results:We have gotten the two-dimensional projection and fitting curvilinear equations of inner surface of cingulate sulcus.Conclusions:The two-dimensional projection may reflect the effluence rule of the cingulate sulcus and cerebral; the location of cingulate sulcus is relative stabilize.
2014, 38(1): 22-25,29.
Abstract:
Objective:To investigate the effect of 3-Bromopyruvate(3-BrPA) combined with adriamycin(ADM) on proliferation and apoptosis of human breast carcinoma cells in vitro.Methods:The effects of 3-BrPA at 80,160 and 320 mol/L on ATP production of MDA-MB-231 breast cancer cells were detected.The growth inhibition effect was detected by MTT assay which induced by 3-BrPA(10,20,40,80,160 mol/L),adriamycin(0.75,1.5,3,6,12 mol/L) and 3-BrPA at 80 mol/L combined with adriamycin(0.75,1.5,3,6,12 mol/L) for 24 h,48 h and 72 h in MDA-MB-231 breast cancer cells.Cells were treated with 3-BrPA (80 mol/L),adriamycin(0.75 mol/L) and 3-BrPA(80 mol/L) combined with adriamycin(0.75 mol/L) for 24 hours,the apoptotic cells were detected using propidium iodide staining by flow cytometry.Cells were treated with 3-BrPA(16 mol/L),adriamycin(0.2 mol/L) and 3-BrPA(16 mol/L) combined with adriamycin(0.5 mol/L) for 5 days,the colony formation was detected by crystal violet staining method.Results:3-BrPA inhibited the formation of ATP in MDA-MB-231 breast cancer cells; 3-BrPA combined with ADM significantly enhanced the cytotoxicity of ADM.When MDA-MB-231 breast cancer cells were treated with 3-BrPA at 80 mol/L combined with ADM at 0.75 mol/L,the apoptosis rate was 39.6%,which was significantly higher than that in control group,3-BrPA group and ADM group(P0.01).3-BrPA enhanced the inhibitory effect of ADM on colony formation of MDA-MB-231 breast cancer cells.Conclusions:3-BrPA can enhance the inhibitory effect of adriamycin on proliferation and apoptosis of MDA-MB-231 breast cancer cells.
Objective:To investigate the effect of 3-Bromopyruvate(3-BrPA) combined with adriamycin(ADM) on proliferation and apoptosis of human breast carcinoma cells in vitro.Methods:The effects of 3-BrPA at 80,160 and 320 mol/L on ATP production of MDA-MB-231 breast cancer cells were detected.The growth inhibition effect was detected by MTT assay which induced by 3-BrPA(10,20,40,80,160 mol/L),adriamycin(0.75,1.5,3,6,12 mol/L) and 3-BrPA at 80 mol/L combined with adriamycin(0.75,1.5,3,6,12 mol/L) for 24 h,48 h and 72 h in MDA-MB-231 breast cancer cells.Cells were treated with 3-BrPA (80 mol/L),adriamycin(0.75 mol/L) and 3-BrPA(80 mol/L) combined with adriamycin(0.75 mol/L) for 24 hours,the apoptotic cells were detected using propidium iodide staining by flow cytometry.Cells were treated with 3-BrPA(16 mol/L),adriamycin(0.2 mol/L) and 3-BrPA(16 mol/L) combined with adriamycin(0.5 mol/L) for 5 days,the colony formation was detected by crystal violet staining method.Results:3-BrPA inhibited the formation of ATP in MDA-MB-231 breast cancer cells; 3-BrPA combined with ADM significantly enhanced the cytotoxicity of ADM.When MDA-MB-231 breast cancer cells were treated with 3-BrPA at 80 mol/L combined with ADM at 0.75 mol/L,the apoptosis rate was 39.6%,which was significantly higher than that in control group,3-BrPA group and ADM group(P0.01).3-BrPA enhanced the inhibitory effect of ADM on colony formation of MDA-MB-231 breast cancer cells.Conclusions:3-BrPA can enhance the inhibitory effect of adriamycin on proliferation and apoptosis of MDA-MB-231 breast cancer cells.
2014, 38(1): 26-29.
Abstract:
Objective:To investigate the effect of melatonin(MT) on the development of nonalcoholic fatty liver disease(NAFLD) in rats with high fat diet and observe the changes of free fatty acid (FFA),to evaluate the protective mechanism of MT on NAFLD.Methods:Fifty male Wistar rats were randomly divided into five groups:control group,model group and the different groups with melatonin at low does,moderate does and high does(MT1,MT2 and MT3 groups).The rats in MT1,MT2 and MT3 groups and model group were fed with high fat diet for 12 weeks while with common diet in normal control group.MT was injected intraperitoneally at 2.5 mgkg-1d-1,5.0 mgkg-1d-1 and 10.0 mgkg-1d-1 respectively in MT1,MT2 and MT3 groups.All rats were sacrificed after 12 weeks.Histopathological changes in liver were observed.The levels of serum alanine aminotransferase (ALT),aspartate aminotransferase(AST),serum and hepatic triglyceride(TG),total cholesterol(TC) and FFA were measured.Results:High fat diet for 12 weeks established rat NAFLD model successfully.Compared with model group,hepatic steatosis was improved in melatonin-treated groups.Serum AST level in model group was higher than in control group(P 0.05),while serum TG level was lower than in control group(P 0.05).The levels of hepatic TC and TG were significantly higher than in control group(P 0.01).Serum ALT level in MT1 group was higher than in control group(P 0.05) and serum TG level in MT1 and MT2 groups were less than in control group (P 0.05).The hepatic TC level in MT1 group,the levels of hepatic TG in MT1,MT2 and MT3 groups were higher than in control group (P 0.01).The level of hepatic TC in MT3 group was lower than in model group (P 0.01).The serum FFA level in model group was higher than in control group(P 0.05 to P 0.01).Compared with model group,serum FFA level in MT groups were reduced(P 0.05 to P 0.01).The hepatic FFA level in model group was higher than in control group(P 0.01).The hepatic FFA content in MT2,MT3 groups were lower than in model group(P 0.01).Conclusions:Melatonin plays the protective and therapeutic effect for NAFLD in a dose dependent manner,may be related to decreasing the production of FFA which improving oxidative stress and depressing lipid peroxidation in rat with high fat diet.
Objective:To investigate the effect of melatonin(MT) on the development of nonalcoholic fatty liver disease(NAFLD) in rats with high fat diet and observe the changes of free fatty acid (FFA),to evaluate the protective mechanism of MT on NAFLD.Methods:Fifty male Wistar rats were randomly divided into five groups:control group,model group and the different groups with melatonin at low does,moderate does and high does(MT1,MT2 and MT3 groups).The rats in MT1,MT2 and MT3 groups and model group were fed with high fat diet for 12 weeks while with common diet in normal control group.MT was injected intraperitoneally at 2.5 mgkg-1d-1,5.0 mgkg-1d-1 and 10.0 mgkg-1d-1 respectively in MT1,MT2 and MT3 groups.All rats were sacrificed after 12 weeks.Histopathological changes in liver were observed.The levels of serum alanine aminotransferase (ALT),aspartate aminotransferase(AST),serum and hepatic triglyceride(TG),total cholesterol(TC) and FFA were measured.Results:High fat diet for 12 weeks established rat NAFLD model successfully.Compared with model group,hepatic steatosis was improved in melatonin-treated groups.Serum AST level in model group was higher than in control group(P 0.05),while serum TG level was lower than in control group(P 0.05).The levels of hepatic TC and TG were significantly higher than in control group(P 0.01).Serum ALT level in MT1 group was higher than in control group(P 0.05) and serum TG level in MT1 and MT2 groups were less than in control group (P 0.05).The hepatic TC level in MT1 group,the levels of hepatic TG in MT1,MT2 and MT3 groups were higher than in control group (P 0.01).The level of hepatic TC in MT3 group was lower than in model group (P 0.01).The serum FFA level in model group was higher than in control group(P 0.05 to P 0.01).Compared with model group,serum FFA level in MT groups were reduced(P 0.05 to P 0.01).The hepatic FFA level in model group was higher than in control group(P 0.01).The hepatic FFA content in MT2,MT3 groups were lower than in model group(P 0.01).Conclusions:Melatonin plays the protective and therapeutic effect for NAFLD in a dose dependent manner,may be related to decreasing the production of FFA which improving oxidative stress and depressing lipid peroxidation in rat with high fat diet.
2014, 38(1): 30-33,37.
Abstract:
Objective:To investigate the gene expression level of PXK MRNA in peripheral blood leucocytes of patients with systemic lupus erythematosis(SLE),and the relationship between the MRNA expression of PXK and the clinical manifestation of SLE.Methods:Sixty SLE patients and 30 controls were enrolled; reverse transcription-polymerase chain reaction technique was used to determine the PXK MRNA expression in the peripheral white blood cells in them.Results:The PXK MRNA expression in the peripheral blood leucocytes of the SLE patients was statistically higher than that of the normal control(P 0.01).The expression level of PXK MRNA in the SLE patients was positively correlated with the production of the anti-SmithD1 antibody(P 0.05); the expression of PXK MRNA in the SLE patients was positively correlated with C3 and C4,respectively(P 0.05).Conclusions:The results indicate that PXK gene may play a role in the pathogenesis of SLE,and might be the susceptibility genes of SLE.
Objective:To investigate the gene expression level of PXK MRNA in peripheral blood leucocytes of patients with systemic lupus erythematosis(SLE),and the relationship between the MRNA expression of PXK and the clinical manifestation of SLE.Methods:Sixty SLE patients and 30 controls were enrolled; reverse transcription-polymerase chain reaction technique was used to determine the PXK MRNA expression in the peripheral white blood cells in them.Results:The PXK MRNA expression in the peripheral blood leucocytes of the SLE patients was statistically higher than that of the normal control(P 0.01).The expression level of PXK MRNA in the SLE patients was positively correlated with the production of the anti-SmithD1 antibody(P 0.05); the expression of PXK MRNA in the SLE patients was positively correlated with C3 and C4,respectively(P 0.05).Conclusions:The results indicate that PXK gene may play a role in the pathogenesis of SLE,and might be the susceptibility genes of SLE.
2014, 38(1): 34-37.
Abstract:
Objective:To explore the technical parameters of magnetic resonance diffusion tensor imaging(DTI) in corpus callosum. Methods:The DTI of the sagittal plane were detected in 30 nomarl brains.The effects of b value,slice thickness/interlamellar spacing and diffusion sensitive gradient direction on fractional anisotropy(FA) image quality were compared.Results:Different parameters had different effects on FA image quality.The quality of FA image was best when b value was middle(b = 1000 s/mm²),FA image noise was large at the high b value(b = 1500 s/mm²),and the contrast of FA image was poor at the low b value(b = 500 s/mm²).The signal to noise ratio was high with slice thickness/interlamellar spacing increasing,the subtle structure was easy to miss.The differences of FA image qualities at 13 and 25 diffusion sensitive gradient directions statistical significance (P 0.05).The FA image quality at 6 diffusion sensitive gradient direction was worse hadno.Conclusions:The 1000 s/mm² of b value,5 mm/0 mm of slice thickness and 15 diffusion sensitive gradient directions are suitable for DTI of corpus callosum in the sagittal head in clinic.
Objective:To explore the technical parameters of magnetic resonance diffusion tensor imaging(DTI) in corpus callosum. Methods:The DTI of the sagittal plane were detected in 30 nomarl brains.The effects of b value,slice thickness/interlamellar spacing and diffusion sensitive gradient direction on fractional anisotropy(FA) image quality were compared.Results:Different parameters had different effects on FA image quality.The quality of FA image was best when b value was middle(b = 1000 s/mm²),FA image noise was large at the high b value(b = 1500 s/mm²),and the contrast of FA image was poor at the low b value(b = 500 s/mm²).The signal to noise ratio was high with slice thickness/interlamellar spacing increasing,the subtle structure was easy to miss.The differences of FA image qualities at 13 and 25 diffusion sensitive gradient directions statistical significance (P 0.05).The FA image quality at 6 diffusion sensitive gradient direction was worse hadno.Conclusions:The 1000 s/mm² of b value,5 mm/0 mm of slice thickness and 15 diffusion sensitive gradient directions are suitable for DTI of corpus callosum in the sagittal head in clinic.
2014, 38(1): 38-40.
Abstract:
Objective:To compare the phenotype and functional changes between decidual natural killer(dNK) cells and peripheral natural killer (pNK) cells,and investigate the relationship of dNK cells specific phenotype and the immunotolerance regulated mechanism at fetal-maternal interface.Methods:The phenotype of dNK cells and pNK cells was analyzed with flow cytometry.dNK cells and pNK cells were separated by MACS,lactate dehydrogenase was used to determine the cytotoxic activity on K562 cells.Results:CD16 expression on dNK cells was significantly lower than on pNK cells(P 0.01).NKG2A expression on dNK cells was higher than that on pNK cells(P 0.01),NKG2D expression on dNK cells was lower than on pNK cells(P 0.05).The cytotoxic activity of dNK cells on K562 cells was significantly lower than that of pNK cells.Conclusions:The specific phenotype and function of dNK cells may be an important factors for the immunotolerance maintenance at fetal-maternal interface during pregnancy.
Objective:To compare the phenotype and functional changes between decidual natural killer(dNK) cells and peripheral natural killer (pNK) cells,and investigate the relationship of dNK cells specific phenotype and the immunotolerance regulated mechanism at fetal-maternal interface.Methods:The phenotype of dNK cells and pNK cells was analyzed with flow cytometry.dNK cells and pNK cells were separated by MACS,lactate dehydrogenase was used to determine the cytotoxic activity on K562 cells.Results:CD16 expression on dNK cells was significantly lower than on pNK cells(P 0.01).NKG2A expression on dNK cells was higher than that on pNK cells(P 0.01),NKG2D expression on dNK cells was lower than on pNK cells(P 0.05).The cytotoxic activity of dNK cells on K562 cells was significantly lower than that of pNK cells.Conclusions:The specific phenotype and function of dNK cells may be an important factors for the immunotolerance maintenance at fetal-maternal interface during pregnancy.
2014, 38(1): 41-42.
Abstract:
Objective:To investigate the clinical value of improved Vechitti vaginoplasty by Ｒetzius gap puncture for treatment of congenital absence of vagina and uterus.Methods:The puncture was performed in the upper border of the symphysis pubis toward the vestibula through the abdominal wall,then a traction thread whose terminal was fixed by a button was drawn through the Ｒetzius gap and lifted from the belly; at the same time,the technique of vaginal pushing-up was applied.Eventually,the vagina was reconstructed.Results:The improved Vechitti vaginoplasty by Ｒetzius gap puncture was successful in all the 10 patients; three months later,the average vaginal length was 9-10 cm with normal elasticity and color.Conclusions:The improved Vechitti vaginoplasty has the advantages of easy operation and minimal invasion.It is worth popularizing.
Objective:To investigate the clinical value of improved Vechitti vaginoplasty by Ｒetzius gap puncture for treatment of congenital absence of vagina and uterus.Methods:The puncture was performed in the upper border of the symphysis pubis toward the vestibula through the abdominal wall,then a traction thread whose terminal was fixed by a button was drawn through the Ｒetzius gap and lifted from the belly; at the same time,the technique of vaginal pushing-up was applied.Eventually,the vagina was reconstructed.Results:The improved Vechitti vaginoplasty by Ｒetzius gap puncture was successful in all the 10 patients; three months later,the average vaginal length was 9-10 cm with normal elasticity and color.Conclusions:The improved Vechitti vaginoplasty has the advantages of easy operation and minimal invasion.It is worth popularizing.
2014, 38(1): 43-46.
Abstract:
Objective:To investigate the clinical effects of early intravenous infusion recombinant human brain natriuretic peptide (rhBNP) combined with noninvasive positive pressure ventilation(NIPPV) in the treatment of patients with decompensated acute heart failure.Methods:The clinical data including age,gender,past medical history,N-terminal pro-brain natriuretic peptide(NT-proBNP) at 1,2,3,5,7 and 10 days after hospitalization,oxygenation index and the time of NIPPV of 112 patients with decompensated acute heart failure were retrospectively analyzed.All patients were divided into drug group and control group according to whether the rhBNP was used.NT-proBNP,oxygenation index and the time of NIPPV in two groups were compared.According to the results of multivariate regression analysis,the fitting curve were drawed,the relativity between the variance ratio of NT-proBNP and oxygenation index and the time of NIPPV were analyzed.Results:The falling NT-proBNP level and rising oxygenation index level in drug group were higher than those in control group(P 0.01).Multivariate regression analysis showed that age[odds ratio(OＲ) = 1.174,95%,95% CI(1.797 to 1.910),P 0.01],the variance ratio of NT-proBNP[OＲ = 1.363,95% CI(1.936 to 2.358),P 0.05] and the variance ratio of oxygenation index[OＲ = 2.088,95%CI(1.273 to 1.847),P 0.05]were correlated to the time of NIPPV.The variance ratio of NTproBNP and oxygenation index,and the time of NIPPV in fitting curve showed linear correlation(P 0.05).Conclusions:Early intravenous infusion recombinant rhBNP combined with NIPPV in the treatment of patients with decompensated acute heart failure can decrease the level of NT-proBNP,increase oxygenation index and short the time of NIVPPV,which can obviously improve the outcome of the patients.
Objective:To investigate the clinical effects of early intravenous infusion recombinant human brain natriuretic peptide (rhBNP) combined with noninvasive positive pressure ventilation(NIPPV) in the treatment of patients with decompensated acute heart failure.Methods:The clinical data including age,gender,past medical history,N-terminal pro-brain natriuretic peptide(NT-proBNP) at 1,2,3,5,7 and 10 days after hospitalization,oxygenation index and the time of NIPPV of 112 patients with decompensated acute heart failure were retrospectively analyzed.All patients were divided into drug group and control group according to whether the rhBNP was used.NT-proBNP,oxygenation index and the time of NIPPV in two groups were compared.According to the results of multivariate regression analysis,the fitting curve were drawed,the relativity between the variance ratio of NT-proBNP and oxygenation index and the time of NIPPV were analyzed.Results:The falling NT-proBNP level and rising oxygenation index level in drug group were higher than those in control group(P 0.01).Multivariate regression analysis showed that age[odds ratio(OＲ) = 1.174,95%,95% CI(1.797 to 1.910),P 0.01],the variance ratio of NT-proBNP[OＲ = 1.363,95% CI(1.936 to 2.358),P 0.05] and the variance ratio of oxygenation index[OＲ = 2.088,95%CI(1.273 to 1.847),P 0.05]were correlated to the time of NIPPV.The variance ratio of NTproBNP and oxygenation index,and the time of NIPPV in fitting curve showed linear correlation(P 0.05).Conclusions:Early intravenous infusion recombinant rhBNP combined with NIPPV in the treatment of patients with decompensated acute heart failure can decrease the level of NT-proBNP,increase oxygenation index and short the time of NIVPPV,which can obviously improve the outcome of the patients.
2014, 38(1): 47-49.
Abstract:
Objective:To investigate the dynamic change of peripheral blood prostaglandin E2(PGE2) level before and after operation and its clinical significance in patients with colorectal carcinoma.Methods:Sixty-one patients with colorectal carcinoma were divided into Non-distant metastasis group 46 cases and distant metastasis 15 cases,thirty healthy people formed the control group.Among 61 patients,forty-one,eleven and nine cases were treated with resection,palliative resection and laparotomy,respectively.The PGE2 levels of peripheral blood and tumor tissue before and after operation in patients and normal colorectal mucosa and peripheral blood in healthy people were detected.Results:The PGE2 levels of peripheral blood before operation in patients with colorectal carcinoma were obviously increased,the PGE2 levels of patients with stage D were significantly higher than that in stage A,B and C(P 0.01).The level of peripheral blood PGE2 in patients with Non-distant metastasis was positive correlation with tumor size(P 0.01).The level of PGE2 in tumor tissue was significant higher than that in normal colorectal mucosa(P 0.01).The PGE2 levels of peripheral blood after were operation decreased significantly,the PGE2 level difference between the patients treated with resection and healthy people was not statistical significance(P 0.05).The PGE2 levels of patients treated with palliative resection and laparotomy were significantly higher that in control group(P 0.01).Conclusions:The high PGE2 level of peripheral blood in patients with colorectal carcinoma originated from the tumor.The dynamic detection of peripheral blood PGE2 may be considered as an auxiliary index in predicting the recurrence and metastasis of colorectal carcinoma after radical resection.
Objective:To investigate the dynamic change of peripheral blood prostaglandin E2(PGE2) level before and after operation and its clinical significance in patients with colorectal carcinoma.Methods:Sixty-one patients with colorectal carcinoma were divided into Non-distant metastasis group 46 cases and distant metastasis 15 cases,thirty healthy people formed the control group.Among 61 patients,forty-one,eleven and nine cases were treated with resection,palliative resection and laparotomy,respectively.The PGE2 levels of peripheral blood and tumor tissue before and after operation in patients and normal colorectal mucosa and peripheral blood in healthy people were detected.Results:The PGE2 levels of peripheral blood before operation in patients with colorectal carcinoma were obviously increased,the PGE2 levels of patients with stage D were significantly higher than that in stage A,B and C(P 0.01).The level of peripheral blood PGE2 in patients with Non-distant metastasis was positive correlation with tumor size(P 0.01).The level of PGE2 in tumor tissue was significant higher than that in normal colorectal mucosa(P 0.01).The PGE2 levels of peripheral blood after were operation decreased significantly,the PGE2 level difference between the patients treated with resection and healthy people was not statistical significance(P 0.05).The PGE2 levels of patients treated with palliative resection and laparotomy were significantly higher that in control group(P 0.01).Conclusions:The high PGE2 level of peripheral blood in patients with colorectal carcinoma originated from the tumor.The dynamic detection of peripheral blood PGE2 may be considered as an auxiliary index in predicting the recurrence and metastasis of colorectal carcinoma after radical resection.
2014, 38(1): 50-52.
Abstract:
Objective:To compare the clinical effects of proximal femoral nail antirotation(PFNA) with dynamic hip screw(DHS) in the treatment of femoral trochanter fractures.Methods:Intraoperative and postoperative complications and postoperative hip joint function recovery of 29 cases treated with PFNA(PFNA group) and 36 cases treated with DHS(DHS group) were analyzed.Results:Compared with DHS group,the time of operation and ambulation and intraoperative bleeding in PFNA group were less(P 0.01).The differences of the healing time of fracture and excellent rate of Harris score in two group were not statistically significant(P 0.05).Conclusions:PFNA is easy operating,less trauma and bleeding and tight fixation.Postoperative patients can early ambulate.PFNA is a ideal means for treating femoral trochanter fractures.
Objective:To compare the clinical effects of proximal femoral nail antirotation(PFNA) with dynamic hip screw(DHS) in the treatment of femoral trochanter fractures.Methods:Intraoperative and postoperative complications and postoperative hip joint function recovery of 29 cases treated with PFNA(PFNA group) and 36 cases treated with DHS(DHS group) were analyzed.Results:Compared with DHS group,the time of operation and ambulation and intraoperative bleeding in PFNA group were less(P 0.01).The differences of the healing time of fracture and excellent rate of Harris score in two group were not statistically significant(P 0.05).Conclusions:PFNA is easy operating,less trauma and bleeding and tight fixation.Postoperative patients can early ambulate.PFNA is a ideal means for treating femoral trochanter fractures.
2014, 38(1): 52-54.
Abstract:
Objective:To compare the clinical effects of proximal femoral nail antirotation(PFNA) with dynamic hip screw(DHS) in the treatment of femoral trochanter fractures.Methods:Intraoperative and postoperative complications and postoperative hip joint function recovery of 29 cases treated with PFNA(PFNA group) and 36 cases treated with DHS(DHS group) were analyzed.Results:Compared with DHS group,the time of operation and ambulation and intraoperative bleeding in PFNA group were less(P 0.01).The differences of the healing time of fracture and excellent rate of Harris score in two group were not statistically significant(P 0.05).Conclusions:PFNA is easy operating,less trauma and bleeding and tight fixation.Postoperative patients can early ambulate.PFNA is a ideal means for treating femoral trochanter fractures.
Objective:To compare the clinical effects of proximal femoral nail antirotation(PFNA) with dynamic hip screw(DHS) in the treatment of femoral trochanter fractures.Methods:Intraoperative and postoperative complications and postoperative hip joint function recovery of 29 cases treated with PFNA(PFNA group) and 36 cases treated with DHS(DHS group) were analyzed.Results:Compared with DHS group,the time of operation and ambulation and intraoperative bleeding in PFNA group were less(P 0.01).The differences of the healing time of fracture and excellent rate of Harris score in two group were not statistically significant(P 0.05).Conclusions:PFNA is easy operating,less trauma and bleeding and tight fixation.Postoperative patients can early ambulate.PFNA is a ideal means for treating femoral trochanter fractures.
2014, 38(1): 55-58.
Abstract:
Objective:To obseRve the effect of -3 polyunsatuRated fatty acids in tReatment of seveRe bRain injuRy complicated by lung infection.Methods:Fifty-six cases of seveRe bRain injuRy accompanied by pulmonaRy infection weRe Randomly divided into contRol gRoup(gRoup A) and -3 polyunsatuRated fatty acids gRoup(gRoup B).GRoup B weRe administeRed -3 polyunsatuRated fatty acids in addition to the Routine theRapy.All the patients weRe given Relevant examinations and tReatment such as antibiotics,Reducing the intRacRanial pRessuRe,endotRacheal intubation,ventilatoR application and post-tRacheotomy.Both gRoups weRe given eneRgy supplement 105-125 kJkg-1d-1,but in gRoup B,some of the heat was pRovided by the fat emulsion of -3 polyunsatuRated fatty acids.On the 0th,2 nd,4 th and 7th day,the patients' white blood cell(WBC),C Reactive pRotein(CRP) and lymphocyte subsets classification weRe monitoRed; and the tumoR necRosis factoR-(TNF-),inteRleukin-6(IL-6) and IL-10 weRe tested in the lavage fluid by enzyme linked immunosoRbent assay.Results:The expRession of TNF- in the lavage fluid of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-6 in the lavage fluid of gRoup B on the 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-10 in the lavage fluid of the two gRoups was not statistically diffeRent(P 0.05).The WBC level of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CRP level of gRoup B on the 2nd,4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CD4/CD8 Ratio of gRoup B on the 2nd,4 th and 7th day was significantly higheR than that of the contRol(P 0.01).Conclusions:-3 polyunsatuRated fatty acids can impRove the immunity of patients with seveRe bRain injuRy complicated by lung infection and have a pRotective effect on the lung.
Objective:To obseRve the effect of -3 polyunsatuRated fatty acids in tReatment of seveRe bRain injuRy complicated by lung infection.Methods:Fifty-six cases of seveRe bRain injuRy accompanied by pulmonaRy infection weRe Randomly divided into contRol gRoup(gRoup A) and -3 polyunsatuRated fatty acids gRoup(gRoup B).GRoup B weRe administeRed -3 polyunsatuRated fatty acids in addition to the Routine theRapy.All the patients weRe given Relevant examinations and tReatment such as antibiotics,Reducing the intRacRanial pRessuRe,endotRacheal intubation,ventilatoR application and post-tRacheotomy.Both gRoups weRe given eneRgy supplement 105-125 kJkg-1d-1,but in gRoup B,some of the heat was pRovided by the fat emulsion of -3 polyunsatuRated fatty acids.On the 0th,2 nd,4 th and 7th day,the patients' white blood cell(WBC),C Reactive pRotein(CRP) and lymphocyte subsets classification weRe monitoRed; and the tumoR necRosis factoR-(TNF-),inteRleukin-6(IL-6) and IL-10 weRe tested in the lavage fluid by enzyme linked immunosoRbent assay.Results:The expRession of TNF- in the lavage fluid of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-6 in the lavage fluid of gRoup B on the 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-10 in the lavage fluid of the two gRoups was not statistically diffeRent(P 0.05).The WBC level of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CRP level of gRoup B on the 2nd,4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CD4/CD8 Ratio of gRoup B on the 2nd,4 th and 7th day was significantly higheR than that of the contRol(P 0.01).Conclusions:-3 polyunsatuRated fatty acids can impRove the immunity of patients with seveRe bRain injuRy complicated by lung infection and have a pRotective effect on the lung.
2014, 38(1): 58-60.
Abstract:
Objective:To explore the mean platelet volume(MPV) change of platelet parameters in type 2 diabetic patient and its relation with diabetic nephropathy.Methods:The parameters of platelet count(PLT),mean platelet volume(MPV) platelet distribution width(PDW),triglyceride (TG),total cholesterol (TC),fasting plasma glucose (FPG),glycated hemoglobin (HbA1C),24 h microalbumin urine(24h-MAU) and serum creatinine(Scr) of 180 type 2 diabetic patients and 142 health physical examination people were measured.Results:The age,FPG,TG,MPV and PDW of type 2 diabetic patients were higher than that in healthy people,but for PLT,it was lower than that in healthy people(P 0.05 to P 0.01).In type 2 diabetic patients,the levels of PDW,24 h-MAU of MPV 11 fl group were higher than that in MPV11 fl group,but for PLT,it was lower than that in MPV11 fl group(P 0.05 to P 0.01).Conclusions:The MPV of type 2 diabetic patients is increased,and which is positively related to the severity of the diabetic nephropathy.
Objective:To explore the mean platelet volume(MPV) change of platelet parameters in type 2 diabetic patient and its relation with diabetic nephropathy.Methods:The parameters of platelet count(PLT),mean platelet volume(MPV) platelet distribution width(PDW),triglyceride (TG),total cholesterol (TC),fasting plasma glucose (FPG),glycated hemoglobin (HbA1C),24 h microalbumin urine(24h-MAU) and serum creatinine(Scr) of 180 type 2 diabetic patients and 142 health physical examination people were measured.Results:The age,FPG,TG,MPV and PDW of type 2 diabetic patients were higher than that in healthy people,but for PLT,it was lower than that in healthy people(P 0.05 to P 0.01).In type 2 diabetic patients,the levels of PDW,24 h-MAU of MPV 11 fl group were higher than that in MPV11 fl group,but for PLT,it was lower than that in MPV11 fl group(P 0.05 to P 0.01).Conclusions:The MPV of type 2 diabetic patients is increased,and which is positively related to the severity of the diabetic nephropathy.
2014, 38(1): 61-63.
Abstract:
Objective:To investigate the clinical application of new standard of gestational diabetes mellitus(GDM).Methods:Eight hundred pregnant women(study group) were tested by 75 g oral glucose tolerance test(OGTT) according to the new standard after 24 weeks of pregnancy.Seven hundred and fifty pregnant women(control group) were tested by 50 g OGTT,then 75 g OGTT was added in the patients with sugar sieve abnormality after 24 weeks of pregnancy.Results:The pregnant women screening rate of study group(97.50%) was significantly higher than that in control group(87.07%) (P 0.01).The prevalence rate of GDM in study group and control group were 6.25% and 4.13%,respectively,the difference of which was not statistical significance(P 0.05).Conclusions:The screening rate of study group is better than that in control group,its prevalence rate of GDM increases according to new standard.
Objective:To investigate the clinical application of new standard of gestational diabetes mellitus(GDM).Methods:Eight hundred pregnant women(study group) were tested by 75 g oral glucose tolerance test(OGTT) according to the new standard after 24 weeks of pregnancy.Seven hundred and fifty pregnant women(control group) were tested by 50 g OGTT,then 75 g OGTT was added in the patients with sugar sieve abnormality after 24 weeks of pregnancy.Results:The pregnant women screening rate of study group(97.50%) was significantly higher than that in control group(87.07%) (P 0.01).The prevalence rate of GDM in study group and control group were 6.25% and 4.13%,respectively,the difference of which was not statistical significance(P 0.05).Conclusions:The screening rate of study group is better than that in control group,its prevalence rate of GDM increases according to new standard.
2014, 38(1): 63-65.
Abstract:
Objective:To compare the effects of ketamine,sevoflurane,sufentanil,remifentanil and propofol on the hemodynamic change and awakening quality during the anesthesia of head and neck surgery in children.Methods:One hundred children with elective head and neck surgery were randomly divided into ketamine group(group A),ketamine remifentanil group(group B),sevoflurane group(group C),sufentanil propofol group(group D) and remifentanil propofol group(group E) (20 cases each group).The mean arterial blood pressure and heart rate of all groups were measured before intubation,during intubation,10 minutes of surgery,the end of operation and during extubation.The recovery time of spontaneous breathing,eye opening time,extubation time and agitation after extubation were observed after operation.Results:The mean arterial blood pressure and heart rate in group C,D and E were lower than those in group A during intubation and extubation (P 0.01).The recovery time of spontaneous breathing,eye opening time and extubation time in group B,C and E were shorter than that in group A after operation(P 0.05 to P 0.01).Conclusions:Compared with ketamine,remifentanil and sufentanil are beneficial to stabilize hemodynamics,short the awakening time and improve the comfort level during children's anesthesia.
Objective:To compare the effects of ketamine,sevoflurane,sufentanil,remifentanil and propofol on the hemodynamic change and awakening quality during the anesthesia of head and neck surgery in children.Methods:One hundred children with elective head and neck surgery were randomly divided into ketamine group(group A),ketamine remifentanil group(group B),sevoflurane group(group C),sufentanil propofol group(group D) and remifentanil propofol group(group E) (20 cases each group).The mean arterial blood pressure and heart rate of all groups were measured before intubation,during intubation,10 minutes of surgery,the end of operation and during extubation.The recovery time of spontaneous breathing,eye opening time,extubation time and agitation after extubation were observed after operation.Results:The mean arterial blood pressure and heart rate in group C,D and E were lower than those in group A during intubation and extubation (P 0.01).The recovery time of spontaneous breathing,eye opening time and extubation time in group B,C and E were shorter than that in group A after operation(P 0.05 to P 0.01).Conclusions:Compared with ketamine,remifentanil and sufentanil are beneficial to stabilize hemodynamics,short the awakening time and improve the comfort level during children's anesthesia.
2014, 38(1): 66-67.
Abstract:
Objective:To investigate the feasibility,clinical effects,safety,induction of labor in mid-pregnancy patients with uterine scar treated by mifepristone combined with ethacridine.Methods:Ninety-eight mid-pregnant women with uterine scar were randomly divided into group A(mifepristone conbined with ethacridine) and group B(ethacridine only),forty-nine cases each group.Success of induced labor,placenta fetal membrane residual rate and cervical laceration rate were observed and compared.Results:Forty-nine cases in group A were all success,3 cases in group B were under cesarean section because of threatened uterine rupture,there were no significant difference in the success rate(P 0.05).Contractions started with cervical maturity,placenta fetal membrane residual rate,cervical laceration rate were significantly different(P 0.01),the effect of induced labor,group A evidently better than group B.Conclusions:Mifepristone combined with ethacridine for mid-pregnancy abortion with uterine scar is safe,convenient,effective and worthy of clinical application.
Objective:To investigate the feasibility,clinical effects,safety,induction of labor in mid-pregnancy patients with uterine scar treated by mifepristone combined with ethacridine.Methods:Ninety-eight mid-pregnant women with uterine scar were randomly divided into group A(mifepristone conbined with ethacridine) and group B(ethacridine only),forty-nine cases each group.Success of induced labor,placenta fetal membrane residual rate and cervical laceration rate were observed and compared.Results:Forty-nine cases in group A were all success,3 cases in group B were under cesarean section because of threatened uterine rupture,there were no significant difference in the success rate(P 0.05).Contractions started with cervical maturity,placenta fetal membrane residual rate,cervical laceration rate were significantly different(P 0.01),the effect of induced labor,group A evidently better than group B.Conclusions:Mifepristone combined with ethacridine for mid-pregnancy abortion with uterine scar is safe,convenient,effective and worthy of clinical application.
2014, 38(1): 68-69.
Abstract:
Objective:To explore the clinical effect of trephination plus drainage on chronic subdural hematoma.Methods:The clinical data of 58 cases of chronic subdural hematoma treated with trephination plus drainage were analyzed retrospectively.Results:Fifty-seven cases were treated with trephination plus drainage,only 1 case that had separate subdural hematoma was converted to craniotomy to remove the hematoma.All the cases were recovered well and no one died.Conclusions:Trephination plus drainage is an effective,safe and reliable procedure for treatment of chronic subdural hematoma.It is worth popularizing in primary hospitals.
Objective:To explore the clinical effect of trephination plus drainage on chronic subdural hematoma.Methods:The clinical data of 58 cases of chronic subdural hematoma treated with trephination plus drainage were analyzed retrospectively.Results:Fifty-seven cases were treated with trephination plus drainage,only 1 case that had separate subdural hematoma was converted to craniotomy to remove the hematoma.All the cases were recovered well and no one died.Conclusions:Trephination plus drainage is an effective,safe and reliable procedure for treatment of chronic subdural hematoma.It is worth popularizing in primary hospitals.
2014, 38(1): 70-72.
Abstract:
Objective:To explore the factors influencing the survival and long-term prognosis of patients having undergone surgical operation for lung sarcomatoid carcinoma.Methods:The clinical data of 22 cases who had received surgical treatment for lung sarcomatoid carcinoma were retrospectively reviewed.The potential prognostic factors were analyzed by COX' s proportional hazard regression model.Results:The overall 1,3 and 5-year survival rates were 63.6%,18.2% and 4.5%,respectively.p-TNM stage and N status were valued as prognostic factors in COX univariate analysis(P 0.05).Age,p-TNM stage and type of pathology were identified as independent prognostic factors by COX multivariate analysis (P 0.01).Conclusions:There is no effective therapy for lung sarcomatoid carcinoma and the 5-year survival rate is quite low.Age,p-TNM stage and type of pathology are the crucial prognostic factors for patients with lung sarcomatoid carcinoma.
Objective:To explore the factors influencing the survival and long-term prognosis of patients having undergone surgical operation for lung sarcomatoid carcinoma.Methods:The clinical data of 22 cases who had received surgical treatment for lung sarcomatoid carcinoma were retrospectively reviewed.The potential prognostic factors were analyzed by COX' s proportional hazard regression model.Results:The overall 1,3 and 5-year survival rates were 63.6%,18.2% and 4.5%,respectively.p-TNM stage and N status were valued as prognostic factors in COX univariate analysis(P 0.05).Age,p-TNM stage and type of pathology were identified as independent prognostic factors by COX multivariate analysis (P 0.01).Conclusions:There is no effective therapy for lung sarcomatoid carcinoma and the 5-year survival rate is quite low.Age,p-TNM stage and type of pathology are the crucial prognostic factors for patients with lung sarcomatoid carcinoma.
2014, 38(1): 72-74.
Abstract:
Objective:To explore the clinical value of video-assisted thoracoscopic sugery(VATS) in the treatment of lung carcer. Methods:Among 21 patients with radical operation of lung cancer,right-upper lung cancer in 6 cases,right-middle lung cancer in 2 cases,right-low lung cancer in 4 cases; left-upper lung cancer in 5 cases and left-low lung cancer in 4 cases were found.The lymph nodes in hilus pulmonis and mediastinum of all patients were cleaned.Results:None was thoracotomy,the operation time was 90 to 250 minutes,the utes intraoperative blood loss was 50 to 600 ml and the closed drainage time was 2 to 4 days.Twenty-one patients lived after following up for 2 to 36 months.The recurrence and metastasis were not found by CT and ECT at 3,6 and 12 months after operation.Conclusions:VATS in the treatment of lung carcer is reliable,safe,fast recovering and less bleeding,but a little expensive.
Objective:To explore the clinical value of video-assisted thoracoscopic sugery(VATS) in the treatment of lung carcer. Methods:Among 21 patients with radical operation of lung cancer,right-upper lung cancer in 6 cases,right-middle lung cancer in 2 cases,right-low lung cancer in 4 cases; left-upper lung cancer in 5 cases and left-low lung cancer in 4 cases were found.The lymph nodes in hilus pulmonis and mediastinum of all patients were cleaned.Results:None was thoracotomy,the operation time was 90 to 250 minutes,the utes intraoperative blood loss was 50 to 600 ml and the closed drainage time was 2 to 4 days.Twenty-one patients lived after following up for 2 to 36 months.The recurrence and metastasis were not found by CT and ECT at 3,6 and 12 months after operation.Conclusions:VATS in the treatment of lung carcer is reliable,safe,fast recovering and less bleeding,but a little expensive.
2014, 38(1): 75-77.
Abstract:
Objective:To evaluate the efficacy and safety of entecavir to chronic hepatitis B(CHB).Methods:Fifty-three patients who had been treated with entecavir(0.5 mg/d) for 12 months were divided into three groups:HBV DNA 107～109 copies/L,HBV DNA 105～106 copies/L,HBV DNA 104 copies/L.Fasting venous blood were collected from each patient after treatment of 1,3,6 and 12 months for detection of hepatitis B viral(HBV) load DNA,alanine aminotransferase(ALT),aspartate transaminase(AST).Results:As the duration of treatment,HBV DNA,ALT,and AST all decreased significantly(P 0.05).three markers were all significantly lower after 1 month treatment than before treatment.Three markers were also significantly lower after 3 month treatment than that after 1 month treatment.As well as,three markers were significantly lower after 12 month treatment than that after 3 month treatment.Additionally,compared with high viral loads group,HBV DNA,ALT,and AST converted negative earlier in lower viral loads group(P 0.05 to P 0.01).Conclusions:Entecavir can suppress HBV replication and improve liver function of the patients.
Objective:To evaluate the efficacy and safety of entecavir to chronic hepatitis B(CHB).Methods:Fifty-three patients who had been treated with entecavir(0.5 mg/d) for 12 months were divided into three groups:HBV DNA 107～109 copies/L,HBV DNA 105～106 copies/L,HBV DNA 104 copies/L.Fasting venous blood were collected from each patient after treatment of 1,3,6 and 12 months for detection of hepatitis B viral(HBV) load DNA,alanine aminotransferase(ALT),aspartate transaminase(AST).Results:As the duration of treatment,HBV DNA,ALT,and AST all decreased significantly(P 0.05).three markers were all significantly lower after 1 month treatment than before treatment.Three markers were also significantly lower after 3 month treatment than that after 1 month treatment.As well as,three markers were significantly lower after 12 month treatment than that after 3 month treatment.Additionally,compared with high viral loads group,HBV DNA,ALT,and AST converted negative earlier in lower viral loads group(P 0.05 to P 0.01).Conclusions:Entecavir can suppress HBV replication and improve liver function of the patients.
2014, 38(1): 77-80.
Abstract:
Objective:To discuss the value of capsule endoscopy in diagnosis of gastrointestinal diseases.Methods:Fifty-six patients received the capsule endoscope examination.The clinical data,executive rate,positive detection rate in the respective parts of the digestive tract and positive rate of obscure gastrointestinal bleeding and other abdominal symptoms were analyzed; The diagnostic value of the capsule endoscope was also assessed.Results:The capsule endoscope examination was completed in 54 of the 56 patients.Pathologic lesions were observed in all the 54 cases.Esophagus and stomach changes were found in 1 case(1.8%),pure stomach changes in 15 cases (27.8%) and stomach and small bowel pathological changes in 38 cases.The detection rates were 1.8%,27.8%and (70.4%).Out of the 19 patients with obscure gastroinstestinal bleeding and 18 out of the 31 patients with abdominal symptoms were proved to have small intestine lesions; the detection rates were 73.7% and 58.1%,respectively.Of the 6 patients with no symptoms,one was confirmed to have reflux esophagitis and 5 had superficial gastritis.Among the 26 elderly patients,one had retained capsule in the stomach and the others went through the capsule endoscopy examination.Conclusions:The capsule endoscopy is effective in detecting intestinal diseases and diagnosis of stomach disorders.It has the advantages of nice compliance.
Objective:To discuss the value of capsule endoscopy in diagnosis of gastrointestinal diseases.Methods:Fifty-six patients received the capsule endoscope examination.The clinical data,executive rate,positive detection rate in the respective parts of the digestive tract and positive rate of obscure gastrointestinal bleeding and other abdominal symptoms were analyzed; The diagnostic value of the capsule endoscope was also assessed.Results:The capsule endoscope examination was completed in 54 of the 56 patients.Pathologic lesions were observed in all the 54 cases.Esophagus and stomach changes were found in 1 case(1.8%),pure stomach changes in 15 cases (27.8%) and stomach and small bowel pathological changes in 38 cases.The detection rates were 1.8%,27.8%and (70.4%).Out of the 19 patients with obscure gastroinstestinal bleeding and 18 out of the 31 patients with abdominal symptoms were proved to have small intestine lesions; the detection rates were 73.7% and 58.1%,respectively.Of the 6 patients with no symptoms,one was confirmed to have reflux esophagitis and 5 had superficial gastritis.Among the 26 elderly patients,one had retained capsule in the stomach and the others went through the capsule endoscopy examination.Conclusions:The capsule endoscopy is effective in detecting intestinal diseases and diagnosis of stomach disorders.It has the advantages of nice compliance.
2014, 38(1): 81-83.
Abstract:
Objective:To observe the clinical effects of nephritis rehabilitation tablet combined with valsartan in the treatment of diabetic nephropathy.Methods:One hundred and twenty patients with diabetic nephropathy were randomly divided into group A(nephritis rehabilitation tablet group,44 cases),group B(valerian group,41 cases) and group C(combination nephritis rehabilitation tablet with valerian group,35 cases).The three groups were treated with nephritis rehabilitation tablet,Valerian and nephritis rehabilitation tablet combined with valerian for 12 weeks after blood glucose and blood pressure were controlled more than 3 weeks,respectively.The urinary microalbumin,urinary transferring and adverse reactions in three groups were recorded.Results:The levels of urinary microalbumin and urinary transferring in group C were lower than those in group A and B(P 0.01).The differences of adverse reactions in three groups were not statistical significance (P 0.05).Conclusions:The effects of nephritis rehabilitation tablet combined with valsartan for treating diabetic nephropathy are better than single drug treatment,and safety in clinical application.
Objective:To observe the clinical effects of nephritis rehabilitation tablet combined with valsartan in the treatment of diabetic nephropathy.Methods:One hundred and twenty patients with diabetic nephropathy were randomly divided into group A(nephritis rehabilitation tablet group,44 cases),group B(valerian group,41 cases) and group C(combination nephritis rehabilitation tablet with valerian group,35 cases).The three groups were treated with nephritis rehabilitation tablet,Valerian and nephritis rehabilitation tablet combined with valerian for 12 weeks after blood glucose and blood pressure were controlled more than 3 weeks,respectively.The urinary microalbumin,urinary transferring and adverse reactions in three groups were recorded.Results:The levels of urinary microalbumin and urinary transferring in group C were lower than those in group A and B(P 0.01).The differences of adverse reactions in three groups were not statistical significance (P 0.05).Conclusions:The effects of nephritis rehabilitation tablet combined with valsartan for treating diabetic nephropathy are better than single drug treatment,and safety in clinical application.
2014, 38(1): 83-85.
Abstract:
Objective:To investigate the application value of laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation.Methods:In 48 cases with gastroduodenal ulcer perforation,18 cases were repaired by laparoscopy(laparoscpy group) and 30 cases were treated with laparotomy(open group).The intraoperative and postoperative situations of two groups were observed and compared.Results:The incision length,intraoperative blood loss,postoperative pain score,enterocinesia recovery time and postoperative hospital stay in laparoscpy group were better than those in open group(P 0.05 to P 0.01).The differences of operation time and postoperative complications in two groups were not statisticalty significant(P 0.05).Conclusions:The laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation is good effects,high safety,less trauma and fast recovery,which is worthy of clinical popularization and application.
Objective:To investigate the application value of laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation.Methods:In 48 cases with gastroduodenal ulcer perforation,18 cases were repaired by laparoscopy(laparoscpy group) and 30 cases were treated with laparotomy(open group).The intraoperative and postoperative situations of two groups were observed and compared.Results:The incision length,intraoperative blood loss,postoperative pain score,enterocinesia recovery time and postoperative hospital stay in laparoscpy group were better than those in open group(P 0.05 to P 0.01).The differences of operation time and postoperative complications in two groups were not statisticalty significant(P 0.05).Conclusions:The laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation is good effects,high safety,less trauma and fast recovery,which is worthy of clinical popularization and application.
2014, 38(1): 88-90,94.
Abstract:
Objective:To investigate the social network status and impacts caused by social relation in quartz sand enterprise workers.Methods:One hundred and ninety quartz sand enterprise workers from four villages and towns of Fengyang county were surveyed by questionnaire,their social support conditions were analyzed.Results:More males(82.10%) with low education level from many local workers participated in the questionnaire.The proportions of local worker,medium and small-sized enterprise worker and female worker,who seeked help from family and friend under social support condition were higher than that of floating population,large enterprise worker and male worker(P 0.05 to P 0.01).The cognitive status of occupational disease in local worker,worker with more than junior high school education and large enterprise worker were better than that in migrant worker,worker with less than junior high school education and medium and small-sized enterprise worker(P 0.05 to P 0.01).The proportion of occupational health training and contracting in large enterprise was higher than that in medium and small-sized enterprise(P 0.01).Conclusions:The social network relation of quartz sand enterprise workers mainly come from family and friend,the available support mainly come from the informal social network relation.The formal social network support should be reinforced.
Objective:To investigate the social network status and impacts caused by social relation in quartz sand enterprise workers.Methods:One hundred and ninety quartz sand enterprise workers from four villages and towns of Fengyang county were surveyed by questionnaire,their social support conditions were analyzed.Results:More males(82.10%) with low education level from many local workers participated in the questionnaire.The proportions of local worker,medium and small-sized enterprise worker and female worker,who seeked help from family and friend under social support condition were higher than that of floating population,large enterprise worker and male worker(P 0.05 to P 0.01).The cognitive status of occupational disease in local worker,worker with more than junior high school education and large enterprise worker were better than that in migrant worker,worker with less than junior high school education and medium and small-sized enterprise worker(P 0.05 to P 0.01).The proportion of occupational health training and contracting in large enterprise was higher than that in medium and small-sized enterprise(P 0.01).Conclusions:The social network relation of quartz sand enterprise workers mainly come from family and friend,the available support mainly come from the informal social network relation.The formal social network support should be reinforced.
2014, 38(1): 91-94.
Abstract:
Objective:To investigate the major death causes of the population over 60 years old and to provide referential basis for the prevention and treatment of the diseases.Methods:According to the National Death Cause Ｒeporting System data and the standard of international classification of diseases(ICD-10),957 death cases aged60 from 2009-2012 in th First Affiliated Hospital of Bengbu Medical College were analyzed.Results:The mortality of population aged60 accounted for 61.54% of the total deaths,and the death cases of the male were much more than those of the female; the death peaks were 70-79 years of age.The first three death causes were malignant tumor,respiratory system disease and circulation system disease; The death causes were related to the age and gender; the major death causes of single disease were pulmonary infections,lung cancer and coronary heart disease.Conclusions:Prevention and treatment of malignant tumors,respiratory system diseases and circulation system diseases should be strengthened to improve the life quality of the aged population.
Objective:To investigate the major death causes of the population over 60 years old and to provide referential basis for the prevention and treatment of the diseases.Methods:According to the National Death Cause Ｒeporting System data and the standard of international classification of diseases(ICD-10),957 death cases aged60 from 2009-2012 in th First Affiliated Hospital of Bengbu Medical College were analyzed.Results:The mortality of population aged60 accounted for 61.54% of the total deaths,and the death cases of the male were much more than those of the female; the death peaks were 70-79 years of age.The first three death causes were malignant tumor,respiratory system disease and circulation system disease; The death causes were related to the age and gender; the major death causes of single disease were pulmonary infections,lung cancer and coronary heart disease.Conclusions:Prevention and treatment of malignant tumors,respiratory system diseases and circulation system diseases should be strengthened to improve the life quality of the aged population.
2014, 38(1): 95-98.
Abstract:
Objective:To study the prevalence status of chronic diseases in the elderly of Muslim and Han population in the community,and to discuss the association of chronic diseases with elderly depression.Methods:Five ageing communities in Yinchuan and Wuzhong were selected by typical sampling.People over the age of 55 were investigated by the geriatric depression scale and a selfmade questionnaire; the survey was conducted one-to-one by unified training investigators.The rate of depression,sort of diseases,score of depression and the rate of twelve chronic diseases were included in the survey.Results:The overall depression rate of the elderly in the community was 32.85% including mild depression(26.43%) and moderately severe depression(6.42%); the detection rates were 35.73% and 31.42% for the Muslim and Han population respectively; the difference was not statistically significant(P 0.05).The overall rate of chronic diseases was 77.52%; the rate of cerebrovascular diseases,arthritis and chronic obstructive pulmonary disease had significant difference between the Muslim population and Han people(P 0.05 to P 0.01)).The incidence of coronary heart diseases,cerebrovascular diseases,arthritis and other diseases was significantly correlated with the occurrence of depressive symptoms (P 0.05 to P 0.01); the rest chronic diseases had no influence on the incidence of depression symptoms (P 0.05).The depression score was positively correlated with the number of diseases one had(P 0.01).Logistic regression showed that besides cerebral embolism,other cerebrovascular diseases,coronary heart diseases and other chronic diseases were also associated with elderly depression(P 0.05 to P 0.01).Conclusions:It is necessary to give attention to the old people with chronic diseases in the community.Knowledge about the prevention of chronic diseases should be populated and physical and mental care strengthened at the same time.
Objective:To study the prevalence status of chronic diseases in the elderly of Muslim and Han population in the community,and to discuss the association of chronic diseases with elderly depression.Methods:Five ageing communities in Yinchuan and Wuzhong were selected by typical sampling.People over the age of 55 were investigated by the geriatric depression scale and a selfmade questionnaire; the survey was conducted one-to-one by unified training investigators.The rate of depression,sort of diseases,score of depression and the rate of twelve chronic diseases were included in the survey.Results:The overall depression rate of the elderly in the community was 32.85% including mild depression(26.43%) and moderately severe depression(6.42%); the detection rates were 35.73% and 31.42% for the Muslim and Han population respectively; the difference was not statistically significant(P 0.05).The overall rate of chronic diseases was 77.52%; the rate of cerebrovascular diseases,arthritis and chronic obstructive pulmonary disease had significant difference between the Muslim population and Han people(P 0.05 to P 0.01)).The incidence of coronary heart diseases,cerebrovascular diseases,arthritis and other diseases was significantly correlated with the occurrence of depressive symptoms (P 0.05 to P 0.01); the rest chronic diseases had no influence on the incidence of depression symptoms (P 0.05).The depression score was positively correlated with the number of diseases one had(P 0.01).Logistic regression showed that besides cerebral embolism,other cerebrovascular diseases,coronary heart diseases and other chronic diseases were also associated with elderly depression(P 0.05 to P 0.01).Conclusions:It is necessary to give attention to the old people with chronic diseases in the community.Knowledge about the prevention of chronic diseases should be populated and physical and mental care strengthened at the same time.
2014, 38(1): 99-102.
Abstract:
Objective:To detect the levels of total cholesterol,triacylglycerol,low-density lipoprotein(LDL),high-density lipoprotein (HDL) and fasting blood glucose in 50 years old crowd with early life exposure to famine,and explore the influence of early life nutrition on adult diseases.Methods:Four thousand two hundred and fourteen adults born in 1957-1963 from a hospital physical examination center in 2011 in Anhui were divided into exposure before famine group(982 cases born in 1957 to 1958),exposure famine group(1 233 cases born in 1959 to 1961) and exposure after famine group(1 999 cases born in 1962 to 1963).The levels of total cholesterol,triacylglycerol,LDL,HDL and fasting blood glucose in three groups were compared.Results:Except the fasting blood glucose level,the differences of the levels of total cholesterol,triacylglycerol,LDL and HDL in different cases had statistical significance (P 0.05 to P 0.01).The level of male triacylglycerol in exposure before famine group was lower than that in exposure after famine group(P 0.01).The levels of female fasting blood glucose,total cholesterol and LDL in exposure before famine group were higher than those in exposure famine group and exposure after famine group(P 0.05 to P 0.01).Conclusions:The early life malnutrition maybe influence the metabolism of blood fat and blood glucose after adult,which may be more remarkable in male with more than 50 years old.The reasonable nutrition in pregnant women has far-reaching significance in preventing chronic metabolic disease in their offspring.
Objective:To detect the levels of total cholesterol,triacylglycerol,low-density lipoprotein(LDL),high-density lipoprotein (HDL) and fasting blood glucose in 50 years old crowd with early life exposure to famine,and explore the influence of early life nutrition on adult diseases.Methods:Four thousand two hundred and fourteen adults born in 1957-1963 from a hospital physical examination center in 2011 in Anhui were divided into exposure before famine group(982 cases born in 1957 to 1958),exposure famine group(1 233 cases born in 1959 to 1961) and exposure after famine group(1 999 cases born in 1962 to 1963).The levels of total cholesterol,triacylglycerol,LDL,HDL and fasting blood glucose in three groups were compared.Results:Except the fasting blood glucose level,the differences of the levels of total cholesterol,triacylglycerol,LDL and HDL in different cases had statistical significance (P 0.05 to P 0.01).The level of male triacylglycerol in exposure before famine group was lower than that in exposure after famine group(P 0.01).The levels of female fasting blood glucose,total cholesterol and LDL in exposure before famine group were higher than those in exposure famine group and exposure after famine group(P 0.05 to P 0.01).Conclusions:The early life malnutrition maybe influence the metabolism of blood fat and blood glucose after adult,which may be more remarkable in male with more than 50 years old.The reasonable nutrition in pregnant women has far-reaching significance in preventing chronic metabolic disease in their offspring.
2014, 38(1): 103-105.
Abstract:
Objective:To evaluate the application value of magnetic resonance cholangiopancreatography (MRCP) in diagnosing cholangiectasis.Methods:The data of MRCP imaging and diagnosis of 45 cases with cholangiectasis diagnosed by clinic and operation were retrospectively analyzed.Results:Among 45 cases with cholangiectasis,choledocholithiasis in 24 cases,cholangiocarcinoma in 10 cases(including 7 cases in hepatic portal and 3 cases in common bile duct),gallbladder carcinoma in 2 cases,pancreatic head carcinoma in 2 cases,choledochocyst in 4 cases and cholangitis stenosis in 3 cases were found.The coincidence rate of MRCP in diagnosing the cholangiectasis and stenosis and the causes of cholangiectasis were 100.00% and 93.33% (42/45),respectively.Conclusions:MRCP is a noninvasive diagnostic tool,which has high accuracy in diagnosing the location and cause of bile duct expansion.MRCP should be a routine means for cholangiectasis.
Objective:To evaluate the application value of magnetic resonance cholangiopancreatography (MRCP) in diagnosing cholangiectasis.Methods:The data of MRCP imaging and diagnosis of 45 cases with cholangiectasis diagnosed by clinic and operation were retrospectively analyzed.Results:Among 45 cases with cholangiectasis,choledocholithiasis in 24 cases,cholangiocarcinoma in 10 cases(including 7 cases in hepatic portal and 3 cases in common bile duct),gallbladder carcinoma in 2 cases,pancreatic head carcinoma in 2 cases,choledochocyst in 4 cases and cholangitis stenosis in 3 cases were found.The coincidence rate of MRCP in diagnosing the cholangiectasis and stenosis and the causes of cholangiectasis were 100.00% and 93.33% (42/45),respectively.Conclusions:MRCP is a noninvasive diagnostic tool,which has high accuracy in diagnosing the location and cause of bile duct expansion.MRCP should be a routine means for cholangiectasis.
2014, 38(1): 106-107.
Abstract:
Objective:To explore the value of B ultrasound combined with -fetoprotein(AFP) in screening liver cancer from highrisk people.Methods:Liver cancer in 1605 high-risk people was screened by B ultrasound combined with AFP detection.Results:Fifteen cases with liver cancer were detected,the positive of AFP in 9 cases were found,6 cases were detected by B ultrasound.Conclusions:The B ultrasound combined with AFP detection in screening liver cancer from high-risk people has important application value,which is the best way to improve the detection rate of liver cancer.
Objective:To explore the value of B ultrasound combined with -fetoprotein(AFP) in screening liver cancer from highrisk people.Methods:Liver cancer in 1605 high-risk people was screened by B ultrasound combined with AFP detection.Results:Fifteen cases with liver cancer were detected,the positive of AFP in 9 cases were found,6 cases were detected by B ultrasound.Conclusions:The B ultrasound combined with AFP detection in screening liver cancer from high-risk people has important application value,which is the best way to improve the detection rate of liver cancer.
2014, 38(1): 110-112.
Abstract:
Objective:To investigate the sonographic features of corpus luteum of pregnancy and its relevant differential diagnosis with other lesions.Methods:The sonographic features of corpus luteum of pregnancy in 96 cases(including 32 cases with normal intrauterine pregnancy,30 cases with intrauterine pregnancy complicated with incomplete abortion and 34 cases with unruptured tubal pregnancy)were retrospectively analyzed,which was compared with tubal pregnancy.Results:Ninety-six corpus luteum of pregnancy and 34 ectopic pregnancy pieces were detected by ultrasound.The thick wall type sonogram luteal cysts were similar to the Dount sign of tubal pregnancy,which was surrounded by abundant blood flow and low resistivity characteristics.In contrast with tubal pregnancy,the corpus luteum of pregnancy was closely related to ovary,some follicles were detected arround it and the ring blood flow was from the ovary.Conclusions:The high detection rate of corpus luteum of pregnancy can be obtain by ultrasound.The correct recognition of the ultrasonographic changes of pregnancy corpus luteum can help to improve its differential diagnosis with other lesions.
Objective:To investigate the sonographic features of corpus luteum of pregnancy and its relevant differential diagnosis with other lesions.Methods:The sonographic features of corpus luteum of pregnancy in 96 cases(including 32 cases with normal intrauterine pregnancy,30 cases with intrauterine pregnancy complicated with incomplete abortion and 34 cases with unruptured tubal pregnancy)were retrospectively analyzed,which was compared with tubal pregnancy.Results:Ninety-six corpus luteum of pregnancy and 34 ectopic pregnancy pieces were detected by ultrasound.The thick wall type sonogram luteal cysts were similar to the Dount sign of tubal pregnancy,which was surrounded by abundant blood flow and low resistivity characteristics.In contrast with tubal pregnancy,the corpus luteum of pregnancy was closely related to ovary,some follicles were detected arround it and the ring blood flow was from the ovary.Conclusions:The high detection rate of corpus luteum of pregnancy can be obtain by ultrasound.The correct recognition of the ultrasonographic changes of pregnancy corpus luteum can help to improve its differential diagnosis with other lesions.
2014, 38(1): 113-114,117.
Abstract:
Objective:To explore the relationship between the levels of myocardial enzymes,cytokines in serum and the severity of hand-foot-mouth disease (HFMD) in children.Methods:The serum of ninety-two children with HFMD were collected,25 cases in severe group,47 cases in mild group and 20 cases in control group.The levels of AST,LDH,CK-MB were analyzed by automatic biochemical analyzer and IL-13,IL-10,TGF- levels were detected by ELISA.Results:The levels of AST,LDH in severe group were obviously higher than that in mild and control groups(P 0.01),CK-MB level in severe group was higher than that in control group(P 0.05); the levels of IL-13,TGF- in severe group were significantly higher than that in mild and control groups(P 0.01),IL-10 level in severe group was higher than that in mild group and control group(P 0.01),and IL-10 level in mild group was higher than that in control group(P 0.01).Conclusions:There is certain clinical value to find severe cases timely and reduce complication by detecting the levels of myocardial enzymes and cytokines.
Objective:To explore the relationship between the levels of myocardial enzymes,cytokines in serum and the severity of hand-foot-mouth disease (HFMD) in children.Methods:The serum of ninety-two children with HFMD were collected,25 cases in severe group,47 cases in mild group and 20 cases in control group.The levels of AST,LDH,CK-MB were analyzed by automatic biochemical analyzer and IL-13,IL-10,TGF- levels were detected by ELISA.Results:The levels of AST,LDH in severe group were obviously higher than that in mild and control groups(P 0.01),CK-MB level in severe group was higher than that in control group(P 0.05); the levels of IL-13,TGF- in severe group were significantly higher than that in mild and control groups(P 0.01),IL-10 level in severe group was higher than that in mild group and control group(P 0.01),and IL-10 level in mild group was higher than that in control group(P 0.01).Conclusions:There is certain clinical value to find severe cases timely and reduce complication by detecting the levels of myocardial enzymes and cytokines.
2014, 38(1): 115-117.
Abstract:
Objective:To observe the level of plasma homocysteine(Hcy) in patients with diabetic nephropathy(DN) and analyze the relationship between the level of Hcy and DN.Methods:The plasma Hcy level of 104 cases of DN including 50 case who were combined with heart and cerebrovascular diseases and 38 healthy controls was measured by enzymatic cycling; their blood glucose (Glu),serum creatinine(Scr),total cholesterol(TC),triglyceride(TG) and high-sensitivity C-reactive protein(hs-CＲP) were also measured.Results:The plasma Hcy level of patients with DN was significantly higher than that of the healthy control(P 0.01); the plasma level of Hcy and hs-CＲP in DN patients combined with cardio-cerebral vascular disease were significantly higher than that of DN patients free of heart and cerebrovascular diseases(P 0.01).Hcy was positive correlated to Scr,TC,TG and hs-CＲP (P 0.05 to P 0.01).Conclusions:The level of Hcy is elevated in patients with DN; Hcy may participate in the genesis of heart and cerebrovascular disease in patients with DN; the incidence of cardio-cerebral vascular diseases in DN patients may be reduced by lowering the plasma Hcy level.
Objective:To observe the level of plasma homocysteine(Hcy) in patients with diabetic nephropathy(DN) and analyze the relationship between the level of Hcy and DN.Methods:The plasma Hcy level of 104 cases of DN including 50 case who were combined with heart and cerebrovascular diseases and 38 healthy controls was measured by enzymatic cycling; their blood glucose (Glu),serum creatinine(Scr),total cholesterol(TC),triglyceride(TG) and high-sensitivity C-reactive protein(hs-CＲP) were also measured.Results:The plasma Hcy level of patients with DN was significantly higher than that of the healthy control(P 0.01); the plasma level of Hcy and hs-CＲP in DN patients combined with cardio-cerebral vascular disease were significantly higher than that of DN patients free of heart and cerebrovascular diseases(P 0.01).Hcy was positive correlated to Scr,TC,TG and hs-CＲP (P 0.05 to P 0.01).Conclusions:The level of Hcy is elevated in patients with DN; Hcy may participate in the genesis of heart and cerebrovascular disease in patients with DN; the incidence of cardio-cerebral vascular diseases in DN patients may be reduced by lowering the plasma Hcy level.
2014, 38(1): 118-120.
Abstract:
Objective:To explore the sensitivity and specificity of normal testing indexes in the diabetic patients whose hemoglobin A1c(HbA1c) abnormal with early renal damage.Methods:Group were divided according to urinary protein qualitative,group A was negative,group B was trace to 1 +,group C was 2 + to 3 +.Urinary protein(IgG,TＲF,mALB,1-m,2-m) were detected by using immune nephelometry method; serum Cys C,BUN and Cr were detected by using the methods of circulatory enzyme,enzyme and picric acid electrode respectively.Results:Each testing index in three groups of diabetes had differences in general(P 0.01),the positive rate of urinary protein of(IgG,TＲF,mALB,2-m and mALB/Cr) in group A was lower than that in group B and C(P 0.05),but 1-m,Cys C,BUN,Cr were lower than that in group C(P 0.05-P 0.01).There were no significant differences between group B and C in each testing indexes(P 0.05).The positive rate of all indexes had significant differences in the group of diabetic and control(P 0.01).The positive rate of IgG,TＲF,2-m,mALB,mALB/Cr in diabetes with negative urine protein was higher than that in control group(P 0.05).There was no significant difference in specificity(P 0.05).Conclusions:As a testing indexes,TＲF,mALB,2-m,mALB/Cr will be more sensitive and specific when compared with other indexes in detecting early diabetic renal damage whose HbA1c is positive and urinary protein qualitative is negative.They can be using to screen early diabetic renal damage alone or combination.
Objective:To explore the sensitivity and specificity of normal testing indexes in the diabetic patients whose hemoglobin A1c(HbA1c) abnormal with early renal damage.Methods:Group were divided according to urinary protein qualitative,group A was negative,group B was trace to 1 +,group C was 2 + to 3 +.Urinary protein(IgG,TＲF,mALB,1-m,2-m) were detected by using immune nephelometry method; serum Cys C,BUN and Cr were detected by using the methods of circulatory enzyme,enzyme and picric acid electrode respectively.Results:Each testing index in three groups of diabetes had differences in general(P 0.01),the positive rate of urinary protein of(IgG,TＲF,mALB,2-m and mALB/Cr) in group A was lower than that in group B and C(P 0.05),but 1-m,Cys C,BUN,Cr were lower than that in group C(P 0.05-P 0.01).There were no significant differences between group B and C in each testing indexes(P 0.05).The positive rate of all indexes had significant differences in the group of diabetic and control(P 0.01).The positive rate of IgG,TＲF,2-m,mALB,mALB/Cr in diabetes with negative urine protein was higher than that in control group(P 0.05).There was no significant difference in specificity(P 0.05).Conclusions:As a testing indexes,TＲF,mALB,2-m,mALB/Cr will be more sensitive and specific when compared with other indexes in detecting early diabetic renal damage whose HbA1c is positive and urinary protein qualitative is negative.They can be using to screen early diabetic renal damage alone or combination.
2014, 38(1): 120-122.
Abstract:
Objective:To investigate the bacteria strain isolated from Lu' an Hospital of Traditional Chinese Medicine and its drug resistance in 2012.Methods:The antimicrobic drug sensitive test was determined by Kirby-Bauer method.Results:During 769 isolated bacteria strains,69.8% of gram-negative bacteria and 30.2% of gram-positive bacteria(including 45.69% of Staphylococcus aureus,42.24% of Coagulase negative Staphylococcus,8.62% of Enterococus and 3.45% of other positive bacteria) were found.One Enterococcus bacterium strain resistanting to Sugar peptide antibiotic vancomycin was detected,its drug resistance rate was 5.0%(1/20).The detection rate of Pneumonia klebsiella and Escherichia coli were 38.9%(37/95) and 48.6%(52/107),respectively.The drug resistance rate of 184 Baumanii strains resistanting to carbapenems was more than 40.0%.The drug resistance rates of 27 Stenotrophomonas maltophilia strains resistanting to levofloxacin and Ticarcillin/clavulanic acid were low.Conclusions:Gramnegative bacteria is the main bacteria in Lu' an Hospital of Traditional Chinese Medicine in 2012.The Acinetobacter spp was highly resistance to carbapenem,Enterobacteriaceae was highly sensitive to carbapenem,and pan-drug resistant strain was not found.
Objective:To investigate the bacteria strain isolated from Lu' an Hospital of Traditional Chinese Medicine and its drug resistance in 2012.Methods:The antimicrobic drug sensitive test was determined by Kirby-Bauer method.Results:During 769 isolated bacteria strains,69.8% of gram-negative bacteria and 30.2% of gram-positive bacteria(including 45.69% of Staphylococcus aureus,42.24% of Coagulase negative Staphylococcus,8.62% of Enterococus and 3.45% of other positive bacteria) were found.One Enterococcus bacterium strain resistanting to Sugar peptide antibiotic vancomycin was detected,its drug resistance rate was 5.0%(1/20).The detection rate of Pneumonia klebsiella and Escherichia coli were 38.9%(37/95) and 48.6%(52/107),respectively.The drug resistance rate of 184 Baumanii strains resistanting to carbapenems was more than 40.0%.The drug resistance rates of 27 Stenotrophomonas maltophilia strains resistanting to levofloxacin and Ticarcillin/clavulanic acid were low.Conclusions:Gramnegative bacteria is the main bacteria in Lu' an Hospital of Traditional Chinese Medicine in 2012.The Acinetobacter spp was highly resistance to carbapenem,Enterobacteriaceae was highly sensitive to carbapenem,and pan-drug resistant strain was not found.
2014, 38(1): 123-125.
Abstract:
Objective:To optimize the undergraduate nursing curriculum in China on the basis of literature analysis.Methods:The study adopted literature analysis,comparative analysis and expert consultation(Delphi method) to optimize the undergraduate nursing educational objectives and the curriculum in China.Results:The total recognition rate of the results is 100%; there are no curriculums meeting the removing standards,while 8 courses are added.The coefficient of variation is less than 0.15,and the expert opinion coordination coefficient is 0.428,explaining that experts opinions are of high coordination.The undergraduate nursing curriculum is finally ascertained to consist five curriculum plates including 46 courses.Conclusions:The occupation ethics,cultural diversity,cross cultural nursing,nursing psychology,nursing prescriber and nursing nutrition are added to the undergraduate nursing curriculum,which makes up the shortage of the current curriculum for nursing students in china and meets the comprehensive training course demand.
Objective:To optimize the undergraduate nursing curriculum in China on the basis of literature analysis.Methods:The study adopted literature analysis,comparative analysis and expert consultation(Delphi method) to optimize the undergraduate nursing educational objectives and the curriculum in China.Results:The total recognition rate of the results is 100%; there are no curriculums meeting the removing standards,while 8 courses are added.The coefficient of variation is less than 0.15,and the expert opinion coordination coefficient is 0.428,explaining that experts opinions are of high coordination.The undergraduate nursing curriculum is finally ascertained to consist five curriculum plates including 46 courses.Conclusions:The occupation ethics,cultural diversity,cross cultural nursing,nursing psychology,nursing prescriber and nursing nutrition are added to the undergraduate nursing curriculum,which makes up the shortage of the current curriculum for nursing students in china and meets the comprehensive training course demand.
2014, 38(1): 126-128.
Abstract:
Objective:To explore the construction of practice base for the major of medical laboratory.Methods:The status and the problem of the practice base construction were investigated and analyzed.Results:Strategy for the practice base construction of the major of medical laboratory was found out.These included pre-practice guide education,evaluation system of practice base,emotional communication,system of rewards and penalties for interns,mutual benefit and reciprocity mechanism,pre-job training system,examining for leading teacher,innovation of practice base model,and funding system.Conclusions:There is a great significance to make an accurate analysis of the status of practice base of medical laboratory and raise construction of practice base for improving clinical practice medical laboratory quality of teaching and quality of interns.
Objective:To explore the construction of practice base for the major of medical laboratory.Methods:The status and the problem of the practice base construction were investigated and analyzed.Results:Strategy for the practice base construction of the major of medical laboratory was found out.These included pre-practice guide education,evaluation system of practice base,emotional communication,system of rewards and penalties for interns,mutual benefit and reciprocity mechanism,pre-job training system,examining for leading teacher,innovation of practice base model,and funding system.Conclusions:There is a great significance to make an accurate analysis of the status of practice base of medical laboratory and raise construction of practice base for improving clinical practice medical laboratory quality of teaching and quality of interns.
2014, 38(1): 129-131.
Abstract:
Objective:To establish a simple and convenient method of preparing and isolating soluble protein from Plasmodium berghei(P.berghei).Methods:SD rats were infected by mouse blood containing P.berghei,and then the rat peripheral blood was collected at the P.berghei-infected late stage.Furthermore the P.berghei-infected ＲBC were isolated by 25% arabic gum.The soluble protein was prepared from P.berghei by ultrasonication.The soluble protein was analyzed by SDS-PAGE,and compared with soluble protein from P.berghei-infected mice.Ｒesults:The large-scale yield of P.berghei can be prepared from P.berghei-infected rats,and the enough soluble protein can be obtained from P.berghei by ultrasonication.The proportion of each protein in soluble protein of P.berghei from infected rats is as the same as the protein from infected mice.Conclusions:The method of separating P.berghei from infected rats is a kind of simple and convenient way.The large-scale quantity of soluble protein antigen of P.berghei can be obtained by ultrasonication.
Objective:To establish a simple and convenient method of preparing and isolating soluble protein from Plasmodium berghei(P.berghei).Methods:SD rats were infected by mouse blood containing P.berghei,and then the rat peripheral blood was collected at the P.berghei-infected late stage.Furthermore the P.berghei-infected ＲBC were isolated by 25% arabic gum.The soluble protein was prepared from P.berghei by ultrasonication.The soluble protein was analyzed by SDS-PAGE,and compared with soluble protein from P.berghei-infected mice.Ｒesults:The large-scale yield of P.berghei can be prepared from P.berghei-infected rats,and the enough soluble protein can be obtained from P.berghei by ultrasonication.The proportion of each protein in soluble protein of P.berghei from infected rats is as the same as the protein from infected mice.Conclusions:The method of separating P.berghei from infected rats is a kind of simple and convenient way.The large-scale quantity of soluble protein antigen of P.berghei can be obtained by ultrasonication.
2014, 38(1): 132-134.
Abstract:
Objective:To explore the influence of high quality nursing service mode on the prognosis of patients with liver cirrhosis combined with hepatic encephalopathy(HE).Methods:Fifty-seven patients with the clinical symptoms of HE were randomly divided into 2 groups.Thirty-one cases in the control group received the routine care and 26 cases in the treatment group were given high quality nursing service in addition to the routine care of HE,which is the implemenation of nursing eare interventions including the oluty to inform ahead of time,psychological counseling,security education preolictive care assessment and prevention,dischange quidance,and a number of post-discharge services such as health education and follow-up.The satisfaction degree and prognosis including the rate of improvement and fatality were compared between the two groups.Results:Twenty-one cases improved and 5 died in the treatment group,while 17 cases improved and 14 died in the control group.The improvement rate of the treatment group was superior to that of the control group(P 0.05).Conclusions:High quality nursing service mode plays an important role in harmonizing the nurse-patient relationship,enhancing the patients' satisfaction degree,and improving the prognosis and life quality of the HE patients.
Objective:To explore the influence of high quality nursing service mode on the prognosis of patients with liver cirrhosis combined with hepatic encephalopathy(HE).Methods:Fifty-seven patients with the clinical symptoms of HE were randomly divided into 2 groups.Thirty-one cases in the control group received the routine care and 26 cases in the treatment group were given high quality nursing service in addition to the routine care of HE,which is the implemenation of nursing eare interventions including the oluty to inform ahead of time,psychological counseling,security education preolictive care assessment and prevention,dischange quidance,and a number of post-discharge services such as health education and follow-up.The satisfaction degree and prognosis including the rate of improvement and fatality were compared between the two groups.Results:Twenty-one cases improved and 5 died in the treatment group,while 17 cases improved and 14 died in the control group.The improvement rate of the treatment group was superior to that of the control group(P 0.05).Conclusions:High quality nursing service mode plays an important role in harmonizing the nurse-patient relationship,enhancing the patients' satisfaction degree,and improving the prognosis and life quality of the HE patients.
2014, 38(1): 135-137.
Abstract:
Objective:To explore the effects of foreseeable nursing on outpatient follow-up patients with rheumatoid arthritis(RA).Methods:One hundred and ten outpatient follow-up patients with RA were randomly divided into control group (50 cases) and observation group(60 cases).The control group were nursed with routine care,the observation group were treated with foreseeable nursing(including psychology,adverse drug reactions,joint functional exercise and daily health care).The influencing factors on negative factor difference and ＲA remission in two groups were compared after following up for 3 and 6 months.Results:After following up for 6 months,the negative factors of observation group were less than that of control group(P 0.05 to P 0.01),the psychological depression and DAS28 score improvement of observation group were significantly better than that of control group (P 0.01).Conclusions:The foreseeable nursing can reduce the negative factors of follow-up patients with RA,ensure the smooth treatment and improve the quality of treatment.
Objective:To explore the effects of foreseeable nursing on outpatient follow-up patients with rheumatoid arthritis(RA).Methods:One hundred and ten outpatient follow-up patients with RA were randomly divided into control group (50 cases) and observation group(60 cases).The control group were nursed with routine care,the observation group were treated with foreseeable nursing(including psychology,adverse drug reactions,joint functional exercise and daily health care).The influencing factors on negative factor difference and ＲA remission in two groups were compared after following up for 3 and 6 months.Results:After following up for 6 months,the negative factors of observation group were less than that of control group(P 0.05 to P 0.01),the psychological depression and DAS28 score improvement of observation group were significantly better than that of control group (P 0.01).Conclusions:The foreseeable nursing can reduce the negative factors of follow-up patients with RA,ensure the smooth treatment and improve the quality of treatment.
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