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2014 Vol. 39, No. 11
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2014, 39(11): 1457-1459,1469.
Abstract:
Objective: To investigate the effects of empyrosis on the proinflammatory cytokines of alveolar lavage fluid in rabbits with early acute lung injury.Methods: Thirty New Zealand white rabbits with 30% Ⅲ degree empyrosis model were established, and divided into five empyrosis groups(n=6) according to the sacrificing time of rabbits(including postempyrosis 2,4,8,12,24 h time points).The 6 healthy rabbits were burnt in water at 37 ℃ and served as the control group.The pathological changes of lung tissue,lung injury scores(LIS) and Wet-dry weight ratio(W/D) in all groups were observed.PMNs were isolated and purified in bronchoalveolar lavage fluid of rabbit.The proinflammatory cytokines(TNF-α, IL-1β and IL-8)in the alveolar lavage fluid of each group were measured by ELISA.Results: The 30% Ⅲ degree empyrosis in all empyrosis groups were verified by pathology.The lyukopedesis and massive infiltration of PMN in alveolar spaces and interstitial edema,pereolate in alveolar spaces, alveolar septum thickerning, alveoli and interstitial hyperemia,alveolar collapse and atelectasis and transparent film formation were found,which aggravated with prolongation of time, and the lung injury scores increasing were measured in all empyrosis groups, the diffeences of which between all groups were statistically significant (P<0.05 to P<0.01). The W/D in rabbits at 8,12 and 24 h after empyrosis were significantly higher than that in control group(P<0.01). The levels of TNF-α, IL-1β and IL-8 in the alveolar lavage fluid after 2,4,8,12 h of empyrosis were higher than those in control group(P<0.05 to P<0.01).The levels of TNF-α and IL-8 peaked at 12 h after empyrosis(P<0.01),the level of IL-1β peaked at 8 h after empyrosis(P<0.01),and the differences of the levels of IL-8 and IL-1β between at 24 h after empyrosis and control group were not statistically significant(P>0.05).Conclusions: The levels of TNF-α,IL-1β and IL-8 in the alveolar lavage fluid significantly increase in early acute lung injury of rabbits with empyrosis, which may lead to the occurrence of early acute lung.
Objective: To investigate the effects of empyrosis on the proinflammatory cytokines of alveolar lavage fluid in rabbits with early acute lung injury.Methods: Thirty New Zealand white rabbits with 30% Ⅲ degree empyrosis model were established, and divided into five empyrosis groups(n=6) according to the sacrificing time of rabbits(including postempyrosis 2,4,8,12,24 h time points).The 6 healthy rabbits were burnt in water at 37 ℃ and served as the control group.The pathological changes of lung tissue,lung injury scores(LIS) and Wet-dry weight ratio(W/D) in all groups were observed.PMNs were isolated and purified in bronchoalveolar lavage fluid of rabbit.The proinflammatory cytokines(TNF-α, IL-1β and IL-8)in the alveolar lavage fluid of each group were measured by ELISA.Results: The 30% Ⅲ degree empyrosis in all empyrosis groups were verified by pathology.The lyukopedesis and massive infiltration of PMN in alveolar spaces and interstitial edema,pereolate in alveolar spaces, alveolar septum thickerning, alveoli and interstitial hyperemia,alveolar collapse and atelectasis and transparent film formation were found,which aggravated with prolongation of time, and the lung injury scores increasing were measured in all empyrosis groups, the diffeences of which between all groups were statistically significant (P<0.05 to P<0.01). The W/D in rabbits at 8,12 and 24 h after empyrosis were significantly higher than that in control group(P<0.01). The levels of TNF-α, IL-1β and IL-8 in the alveolar lavage fluid after 2,4,8,12 h of empyrosis were higher than those in control group(P<0.05 to P<0.01).The levels of TNF-α and IL-8 peaked at 12 h after empyrosis(P<0.01),the level of IL-1β peaked at 8 h after empyrosis(P<0.01),and the differences of the levels of IL-8 and IL-1β between at 24 h after empyrosis and control group were not statistically significant(P>0.05).Conclusions: The levels of TNF-α,IL-1β and IL-8 in the alveolar lavage fluid significantly increase in early acute lung injury of rabbits with empyrosis, which may lead to the occurrence of early acute lung.
2014, 39(11): 1460-1463.
Abstract:
Objective: To clone the activating transcription factor-2(ATF-2) gene,then construct the recombinant eukaryotic expression vector with ATF-2,and explore the effects of ATF-2 on the gene expression of matrix metalloproteinase-20(MMP-20) in mice ameloblasts.Methods: The reverse transcription PCR primers of ATF-2 were designed.The total RNA from the mice ameloblasts was extracted to obtain cDNA for PCR amplification.The ATF-2 gene containing Hind Ⅲ and xhol restriction sites was inserted into the eukaryotic expression vector(pcDNA 3.1/myc-HisA).The effects of ATF-2 on the transcriptional activity of MMP-20 was observed after transfecting the recombinant plasmid.Results: One thousand four hundred and sixty-three bp gene fragment was amplified through PCR.The recombinant eukaryotic expression vector with ATF-2(pcDNA 3.1/myc-HisA-ATF-2) was successful constructed by the verification of dual enzyme digestion and sequencing.The luciferase test showed that ATF-2 gene could promote the expression of MMP-20 promoter(P<0.01).Conclusions: The recombinant pcDNA 3.1/myc-HisA-ATF-2 expression vector is successful constructed.ATF-2 can positive regulate the promoter activity of MMP-20.
Objective: To clone the activating transcription factor-2(ATF-2) gene,then construct the recombinant eukaryotic expression vector with ATF-2,and explore the effects of ATF-2 on the gene expression of matrix metalloproteinase-20(MMP-20) in mice ameloblasts.Methods: The reverse transcription PCR primers of ATF-2 were designed.The total RNA from the mice ameloblasts was extracted to obtain cDNA for PCR amplification.The ATF-2 gene containing Hind Ⅲ and xhol restriction sites was inserted into the eukaryotic expression vector(pcDNA 3.1/myc-HisA).The effects of ATF-2 on the transcriptional activity of MMP-20 was observed after transfecting the recombinant plasmid.Results: One thousand four hundred and sixty-three bp gene fragment was amplified through PCR.The recombinant eukaryotic expression vector with ATF-2(pcDNA 3.1/myc-HisA-ATF-2) was successful constructed by the verification of dual enzyme digestion and sequencing.The luciferase test showed that ATF-2 gene could promote the expression of MMP-20 promoter(P<0.01).Conclusions: The recombinant pcDNA 3.1/myc-HisA-ATF-2 expression vector is successful constructed.ATF-2 can positive regulate the promoter activity of MMP-20.
2014, 39(11): 1464-1466.
Abstract:
Objective: To observe the feature of glomerular endothelial function in rats with early diabetic nephropathy(DN),and evaluate the effect of reduced glutathione on glomerular endothelial function in diabetic rats.Methods: Streptozotocin(60mg/ kg) was injected into peritoneal cavity in the rats to establish animal DN model.The diabetic rats were randomly divided into DN model group and reduced glutathione treated group.Coherent kits were used to detect glomerular nitrogen monoxide(NO),the activity of glomerular endothelial nitric oxide synthase(eNOS),von Willebrand factor(vWF),urinary albumin(UA),superoxide dismutase(SOD),malondialdehyde(MDA) and glutathione peroxidase.Results: Compared with normal control group,glomerular NO,activities of glomerular eNOS were significantly decreased in early DN rats,while the level of vWF and UA significantly increased(P<0.01),and the level of UA was correlated with the level of glomerular vWF(P<0.05).Glomerular SOD,glutathione peroxidase significantly decreased in early DN rats,while MDA was significantly increased(P<0.01).Compared with DN model group,glomerular NO,activities of glomerular eNOS were significantly increased in early DN rats treated with reduced glutathione,while the level of vWF and UA were significantly decreased,and glomerular MDA was significantly increased in early DN rats treated with reduced glutathione(P<0.01).Conclusions: Glomerular endothelial function is indiscriminate in early DN rats,while the level of oxidative stress significantly increases.Reduced glutathione improves glomerular endothelial dysfunction in early DN rats,maybe through reducing oxidative stress.
Objective: To observe the feature of glomerular endothelial function in rats with early diabetic nephropathy(DN),and evaluate the effect of reduced glutathione on glomerular endothelial function in diabetic rats.Methods: Streptozotocin(60mg/ kg) was injected into peritoneal cavity in the rats to establish animal DN model.The diabetic rats were randomly divided into DN model group and reduced glutathione treated group.Coherent kits were used to detect glomerular nitrogen monoxide(NO),the activity of glomerular endothelial nitric oxide synthase(eNOS),von Willebrand factor(vWF),urinary albumin(UA),superoxide dismutase(SOD),malondialdehyde(MDA) and glutathione peroxidase.Results: Compared with normal control group,glomerular NO,activities of glomerular eNOS were significantly decreased in early DN rats,while the level of vWF and UA significantly increased(P<0.01),and the level of UA was correlated with the level of glomerular vWF(P<0.05).Glomerular SOD,glutathione peroxidase significantly decreased in early DN rats,while MDA was significantly increased(P<0.01).Compared with DN model group,glomerular NO,activities of glomerular eNOS were significantly increased in early DN rats treated with reduced glutathione,while the level of vWF and UA were significantly decreased,and glomerular MDA was significantly increased in early DN rats treated with reduced glutathione(P<0.01).Conclusions: Glomerular endothelial function is indiscriminate in early DN rats,while the level of oxidative stress significantly increases.Reduced glutathione improves glomerular endothelial dysfunction in early DN rats,maybe through reducing oxidative stress.
2014, 39(11): 1467-1469.
Abstract:
Objective: To explore the effects of systematic healthy education on the outcomes of patients with impaired glucose tolerance(IGT).Methods: Eighty-six cases with impaired glucose tolerance selected from the clinic clients in our hospital and some communities were divided into the systematic healthy education group(healthy education group) and non-systematic healthy education group(control group) by one-blind control method.The fasting plasma glucose,2 hours plasma glucose of oral glucose tolerance test and glycosylated hemoglobin in two group were measured at start and in 2 years after following-up.The normal conversion and diabetes conversion rates between two groups and their own were statistically analyzed.Results: The levels of the fasting plasma glucose and 2 hours plasma glucose of oral glucose tolerance test in healthy education group were significantly lower than those in control group in 2 years after following up(P<0.01).In healthy education group,the normal conversion rate of glucose tolerance were significantly higher than that in control group(P<0.01),while the conversion rate of diabetes was lower than that in control group(P<0.05).Conclusions: Systematic healthy education can increase the normal conversion rate of glucose tolerance,and reduce the conversion rate of diabetes.
Objective: To explore the effects of systematic healthy education on the outcomes of patients with impaired glucose tolerance(IGT).Methods: Eighty-six cases with impaired glucose tolerance selected from the clinic clients in our hospital and some communities were divided into the systematic healthy education group(healthy education group) and non-systematic healthy education group(control group) by one-blind control method.The fasting plasma glucose,2 hours plasma glucose of oral glucose tolerance test and glycosylated hemoglobin in two group were measured at start and in 2 years after following-up.The normal conversion and diabetes conversion rates between two groups and their own were statistically analyzed.Results: The levels of the fasting plasma glucose and 2 hours plasma glucose of oral glucose tolerance test in healthy education group were significantly lower than those in control group in 2 years after following up(P<0.01).In healthy education group,the normal conversion rate of glucose tolerance were significantly higher than that in control group(P<0.01),while the conversion rate of diabetes was lower than that in control group(P<0.05).Conclusions: Systematic healthy education can increase the normal conversion rate of glucose tolerance,and reduce the conversion rate of diabetes.
2014, 39(11): 1470-1472.
Abstract:
Objective: To evaluate the role of vitamin D in the pathogenesis of type 2 diabetic nephropathy(T2DN) by observing the changes of blood serum vitamin D and biochemical markers of renal function in patients with T2DN.Methods: According to 24 h urinary albumin excretion(24 h-UAE),72 hospitalized patients with T2DN were divided into normal albuminuria group(group A),microalbuminuria group(group B)and macroalbuminuria group(group C),and 22 healthy people were selected as control(group D).the levels of urea(UREA),creatinine(Cr),uric acid(UA),24 h-UAE and serum 25-(OH)D3 were detected;The levels of serum 25-(OH)D3 and biochemical indexes were analyzed and compared among the four groups.Results: The level of serum 25-(OH)D3 in group A,group B and group C was significantly lower than that in group D(P <0.01);the level of serum 25-(OH)D3 in group C was significant lower than that in group A and group B(P <0.01),but the difference was not significant between group A and group B(P>0.05).The level of plasma UREA,Cr and 24 h-UAE in group C were significantly higher than that in group D,group A and group B(P<0.01);but the difference was not significant between group A and group B(P>0.05).The four groups demonstrated no significant difference in UA(P>0.05).Serum 25-(OH)D3 was negatively related to UREA,Cr and 24 h-UAE(P<0.05),and there was no relationship between 25-(OH)D3 and UA(P>0.05).Conclusions: T2DN patients complicated with 25-(OH)D3 deficiency are more prone to kidney diseases.
Objective: To evaluate the role of vitamin D in the pathogenesis of type 2 diabetic nephropathy(T2DN) by observing the changes of blood serum vitamin D and biochemical markers of renal function in patients with T2DN.Methods: According to 24 h urinary albumin excretion(24 h-UAE),72 hospitalized patients with T2DN were divided into normal albuminuria group(group A),microalbuminuria group(group B)and macroalbuminuria group(group C),and 22 healthy people were selected as control(group D).the levels of urea(UREA),creatinine(Cr),uric acid(UA),24 h-UAE and serum 25-(OH)D3 were detected;The levels of serum 25-(OH)D3 and biochemical indexes were analyzed and compared among the four groups.Results: The level of serum 25-(OH)D3 in group A,group B and group C was significantly lower than that in group D(P <0.01);the level of serum 25-(OH)D3 in group C was significant lower than that in group A and group B(P <0.01),but the difference was not significant between group A and group B(P>0.05).The level of plasma UREA,Cr and 24 h-UAE in group C were significantly higher than that in group D,group A and group B(P<0.01);but the difference was not significant between group A and group B(P>0.05).The four groups demonstrated no significant difference in UA(P>0.05).Serum 25-(OH)D3 was negatively related to UREA,Cr and 24 h-UAE(P<0.05),and there was no relationship between 25-(OH)D3 and UA(P>0.05).Conclusions: T2DN patients complicated with 25-(OH)D3 deficiency are more prone to kidney diseases.
2014, 39(11): 1473-1476.
Abstract:
Objective: To investigate the risk factors of stress complications in patients with multiple trauma.Methods: The clinical data of stress complications in 64 patients with multiple trauma were analyzed by univariate and multivariate binary Logistic regression.The data of routine blood,c-reactive protein,blood sugar,blood electrolytes,blood gas analysis,indexes of liver and kidney function,serum total iodine thyroid glycine(TT3),serum free thyroid original three iodine glycine(FT3),total serum thyroxine(TT4),serum free thyroid hormone,thyroid stimulating hormone,adrenocorticotropic hormone(ACTH),blood cortisol(COR),growth hormone,cytokine interleukin(IL)-1,IL-6,IL 8,IL-10 and tumor necrosis factor(TNF-α) in all cases were investigated.Results: The stress ulcer and acute respire distress syndrome of stress complications were found in 48 cases.The differences of the grade Ⅱ scores of acute phsiology and chronic health(APACHⅡ),COR,ACTH,TT3,FT3,TT4,IL-6,IL-8,IL-10 and TNF-α between patients with stress complications and patients without stress complications were statistically significant(P<0.05 to P<0.01).The multivariate analysis showed that APACHⅡ grade,cortisol,TT4,IL-6 and IL-10 were the independent risk factor of early stress complication(P<0.05 to P<0.01).Conclusions: The levels of APACH gradeⅡ,Cortisol,TT4,IL-6 and IL-10 are obviously correlated with the stressgastrointestinalbleeding and respiratory distress syndrome in patients with multiple trauma.
Objective: To investigate the risk factors of stress complications in patients with multiple trauma.Methods: The clinical data of stress complications in 64 patients with multiple trauma were analyzed by univariate and multivariate binary Logistic regression.The data of routine blood,c-reactive protein,blood sugar,blood electrolytes,blood gas analysis,indexes of liver and kidney function,serum total iodine thyroid glycine(TT3),serum free thyroid original three iodine glycine(FT3),total serum thyroxine(TT4),serum free thyroid hormone,thyroid stimulating hormone,adrenocorticotropic hormone(ACTH),blood cortisol(COR),growth hormone,cytokine interleukin(IL)-1,IL-6,IL 8,IL-10 and tumor necrosis factor(TNF-α) in all cases were investigated.Results: The stress ulcer and acute respire distress syndrome of stress complications were found in 48 cases.The differences of the grade Ⅱ scores of acute phsiology and chronic health(APACHⅡ),COR,ACTH,TT3,FT3,TT4,IL-6,IL-8,IL-10 and TNF-α between patients with stress complications and patients without stress complications were statistically significant(P<0.05 to P<0.01).The multivariate analysis showed that APACHⅡ grade,cortisol,TT4,IL-6 and IL-10 were the independent risk factor of early stress complication(P<0.05 to P<0.01).Conclusions: The levels of APACH gradeⅡ,Cortisol,TT4,IL-6 and IL-10 are obviously correlated with the stressgastrointestinalbleeding and respiratory distress syndrome in patients with multiple trauma.
2014, 39(11): 1476-1478.
Abstract:
Objective: To investigate the clinical effect and safety of iodine-131(131I) in the treatment of Graves disease(GD) complicated with leukopenia.Methods: Sixty-six cases of GD complicated with leukopenia were treated by 131I,and the levels of free triiodthyronine(FT3),free thyroxine(FT4),leukocyte and the curative effects were analyzed retrospectively.Results: The levels of FT3 and FT4 at 3,6 and 12 months after 131I therapy reduced markedly(P<0.01),but there was no significant difference among FT3,FT4 or leukocyte at 1 month after 131I therapy(P>0.05).After 6 months' treatment,the GD in 43 cases were cured,the leukocyte in 60 cases returned normal and 6 cases improved.Conclusions: After the therapy of 131I,most of GD patients complicated with leukopenia are cured or turn better.131I therapy is effective and safe for the treatment of GD complicated with leukopenia.
Objective: To investigate the clinical effect and safety of iodine-131(131I) in the treatment of Graves disease(GD) complicated with leukopenia.Methods: Sixty-six cases of GD complicated with leukopenia were treated by 131I,and the levels of free triiodthyronine(FT3),free thyroxine(FT4),leukocyte and the curative effects were analyzed retrospectively.Results: The levels of FT3 and FT4 at 3,6 and 12 months after 131I therapy reduced markedly(P<0.01),but there was no significant difference among FT3,FT4 or leukocyte at 1 month after 131I therapy(P>0.05).After 6 months' treatment,the GD in 43 cases were cured,the leukocyte in 60 cases returned normal and 6 cases improved.Conclusions: After the therapy of 131I,most of GD patients complicated with leukopenia are cured or turn better.131I therapy is effective and safe for the treatment of GD complicated with leukopenia.
2014, 39(11): 1479-1482.
Abstract:
Objective: To explore the clinical value of the percutaneous biopsy guided by CT in the diagnosis of pulmonary aspergillosis.Methods: The clinical data of 34 patients with pulmonary aspergillosis treated with percutaneous paracentesis guided by CT were retrospectively analyzed.Results: Thirty cases with pulmonary aspergillosis were diagnosed by biopsy,4 cases with undiagnosed pulmonary aspergillosis were identified by the surgical pathology.The clinical manifestation showed cough in 25 cases,expectoration in 20 cases,fever in 18 cases,emptysis in 6 cases,chest pain in 5 cases,dyspnea in 5cases and no symptom in 3 cases.The imaging showed nodule in 15 cases(single in 6 cases and multiple in 9 cases),lump in 7 cases,consolidation in 5 cases,infiltrate in 4 cases and air-crescent sign in 3 cases.The positive rate of galactomannan test was 67.6%(23/34).The necrotizing inflammation was the mainly pathological characteristics.The pneumothorax rate was 17.6%(6/34),only one patient was treated with intrathoracic drain,and the others were automatically absorbed.Both 5 cases of needle passage hemorrhage and 1 case of hemoptysis alleviated without treatment.Conclusions: The percutaneous biopsy guided by CT is a safe and effective means in diagnosing pulmonary aspergillosis.
Objective: To explore the clinical value of the percutaneous biopsy guided by CT in the diagnosis of pulmonary aspergillosis.Methods: The clinical data of 34 patients with pulmonary aspergillosis treated with percutaneous paracentesis guided by CT were retrospectively analyzed.Results: Thirty cases with pulmonary aspergillosis were diagnosed by biopsy,4 cases with undiagnosed pulmonary aspergillosis were identified by the surgical pathology.The clinical manifestation showed cough in 25 cases,expectoration in 20 cases,fever in 18 cases,emptysis in 6 cases,chest pain in 5 cases,dyspnea in 5cases and no symptom in 3 cases.The imaging showed nodule in 15 cases(single in 6 cases and multiple in 9 cases),lump in 7 cases,consolidation in 5 cases,infiltrate in 4 cases and air-crescent sign in 3 cases.The positive rate of galactomannan test was 67.6%(23/34).The necrotizing inflammation was the mainly pathological characteristics.The pneumothorax rate was 17.6%(6/34),only one patient was treated with intrathoracic drain,and the others were automatically absorbed.Both 5 cases of needle passage hemorrhage and 1 case of hemoptysis alleviated without treatment.Conclusions: The percutaneous biopsy guided by CT is a safe and effective means in diagnosing pulmonary aspergillosis.
2014, 39(11): 1482-1483.
Abstract:
Objective: To study of the clinical efficacy of catheter-directed thrombolysis in the treatment of acute lower extremity deep vein thrombosis(DVT).Methods: Twenty-eight patients with acute DVT were performed inferior vona cava filter and catheter-directed thrombolysis;the blood flow rate was assessed by imaging test on the 3rd,5th and 7th day after insertion of the catheter.According to the results of the follow-up tests,the therapy of sole balloon dilatation angioplasty or combined with endovascular stenting was applied.The clinical effect was followed up.Results: Catheter-directed thrombolysis was efficacious in all the cases.Sole Balloon dilatation angioplasty was applied to 10 cases and balloon dilatation angioplasty combined with endovascular stenting to 18 cases.All the cases were administered oral anticoagulant and used graduated compression stockings.The follow-up lasted for 6 months to 5 years;and the curative effect proved satisfactory.Conclusions: Catheter-directed thrombolysis and the therapy of sole balloon dilatation angioplasty or combined with endovascular stenting are efficacious procedures for treatment of acute DVT with the advantages of small lesion,high efficacy and few complications,which is of great significance for the prevention and treatment of the disese.
Objective: To study of the clinical efficacy of catheter-directed thrombolysis in the treatment of acute lower extremity deep vein thrombosis(DVT).Methods: Twenty-eight patients with acute DVT were performed inferior vona cava filter and catheter-directed thrombolysis;the blood flow rate was assessed by imaging test on the 3rd,5th and 7th day after insertion of the catheter.According to the results of the follow-up tests,the therapy of sole balloon dilatation angioplasty or combined with endovascular stenting was applied.The clinical effect was followed up.Results: Catheter-directed thrombolysis was efficacious in all the cases.Sole Balloon dilatation angioplasty was applied to 10 cases and balloon dilatation angioplasty combined with endovascular stenting to 18 cases.All the cases were administered oral anticoagulant and used graduated compression stockings.The follow-up lasted for 6 months to 5 years;and the curative effect proved satisfactory.Conclusions: Catheter-directed thrombolysis and the therapy of sole balloon dilatation angioplasty or combined with endovascular stenting are efficacious procedures for treatment of acute DVT with the advantages of small lesion,high efficacy and few complications,which is of great significance for the prevention and treatment of the disese.
2014, 39(11): 1484-1485.
Abstract:
Objective: To observe the efficacy of self-made traditional Chinese medicine(TCM) stomach soup in the treatment of diabetic gastroparesis(DGP).Methods: Sixty cases were divided into treatment group and control group.The two groups received the same basic treatment,in the treatment group,patients drank self-made TCM stomach soup,and in the control group,the patients took domperidone respectively for four weeks as a course of treatment,observed the effects.Results: The total effectiveness rate was 90.0% for the treatment group and 66.7% for the control group.The difference was significant(P<0.05).Conclusions: The efficacy of self-made TCM stomach soup is significantly better than that of domperidone in treating DGP.
Objective: To observe the efficacy of self-made traditional Chinese medicine(TCM) stomach soup in the treatment of diabetic gastroparesis(DGP).Methods: Sixty cases were divided into treatment group and control group.The two groups received the same basic treatment,in the treatment group,patients drank self-made TCM stomach soup,and in the control group,the patients took domperidone respectively for four weeks as a course of treatment,observed the effects.Results: The total effectiveness rate was 90.0% for the treatment group and 66.7% for the control group.The difference was significant(P<0.05).Conclusions: The efficacy of self-made TCM stomach soup is significantly better than that of domperidone in treating DGP.
2014, 39(11): 1486-1487.
Abstract:
Objective: To explore the clinical effects of the adjustable ventriculo-peritoneal shunt valve in treating adult hydrocephalus.Methods: Twenty cases with hydrocephalus were treated with the adjustable ventriculo-peritoneal shunt valve.The valve pressure was adjusted according to the intracranial pressure of patients during the operation and the ventricular size in CT and the clinical symptoms after operation.The valve increased or decreased 1 level every month according to the brain CT.Results: All patients were followed up for 3 to 19 months.The high-pressure hydrocephalus symptoms were improved in 5 cases,the valve in 1 case with less ventricle was adjusted to high 1 level.Among 15 cases with normal-pressure hydrocephalus,the improvement in 8 cases and no obvious improvement in 7 cases were found.Among 8 cases treated with adjustment,the improvement of symptom and imaging in 7 cases and no obvious improvement in 1 case were found.Conclusions: The clinical effects of the adjustable ventriculo-peritoneal shunt valve are good,which can prevent complications.
Objective: To explore the clinical effects of the adjustable ventriculo-peritoneal shunt valve in treating adult hydrocephalus.Methods: Twenty cases with hydrocephalus were treated with the adjustable ventriculo-peritoneal shunt valve.The valve pressure was adjusted according to the intracranial pressure of patients during the operation and the ventricular size in CT and the clinical symptoms after operation.The valve increased or decreased 1 level every month according to the brain CT.Results: All patients were followed up for 3 to 19 months.The high-pressure hydrocephalus symptoms were improved in 5 cases,the valve in 1 case with less ventricle was adjusted to high 1 level.Among 15 cases with normal-pressure hydrocephalus,the improvement in 8 cases and no obvious improvement in 7 cases were found.Among 8 cases treated with adjustment,the improvement of symptom and imaging in 7 cases and no obvious improvement in 1 case were found.Conclusions: The clinical effects of the adjustable ventriculo-peritoneal shunt valve are good,which can prevent complications.
2014, 39(11): 1488-1490.
Abstract:
Objective: To explore the causes,treatment and prevention of the complications after ventriculoperitoneal shunt.Methods: The surgical procedure,prognosis and complication of 75 patients who had accepted ventriculopefitoneal shunt were retrospectively reviewed.Results: Complete recovery was observed in 43 cases,duct block in 16 cases,infection in 13 cases,excessive shunt in 2 cases and bowel perforation in 1 case.Conclusions: Strict disinfection,aseptic and normative operation,meticulous observation and timely management of the complications in patients having received ventriculopefitoneal shunt are essential in improving the clinical efficacy;it is suggested that patients whose drainage tube are repeatedly blocked resort to ventricle-umbilicus-portal vein shunt.
Objective: To explore the causes,treatment and prevention of the complications after ventriculoperitoneal shunt.Methods: The surgical procedure,prognosis and complication of 75 patients who had accepted ventriculopefitoneal shunt were retrospectively reviewed.Results: Complete recovery was observed in 43 cases,duct block in 16 cases,infection in 13 cases,excessive shunt in 2 cases and bowel perforation in 1 case.Conclusions: Strict disinfection,aseptic and normative operation,meticulous observation and timely management of the complications in patients having received ventriculopefitoneal shunt are essential in improving the clinical efficacy;it is suggested that patients whose drainage tube are repeatedly blocked resort to ventricle-umbilicus-portal vein shunt.
2014, 39(11): 1491-1494.
Abstract:
Objective: To compare the clinical and pathological features,molecular subtypes and prognosis of breast cancer between young and elderly patients.Methods: Fifty-six young patients with breast cancer,18 to 30 years old,and 120 elderly patients with breast cancer,45 to 70 years old,were divided into the young group and elderly group,respectively.The clinical and pathological features,molecular subtypes and prognosis between two groups were compared.Results: The differences of the tumor size,lymph node metastasis,histological grade,molecular subtype and tumor recurrence between two groups were statistically significant(P<0.05 to P<0.01).The triple negative breast cancer occurred most often in young group.Conclusions: The clinical symptom of breast cancer in young patient is concealment,and its prognosis is poor.The clinical and pathological features,subtypes and prognosis of breast cancer in young patients are different from that in the elderly patients,the early diagnosis and treatment of which should be paid attention to.
Objective: To compare the clinical and pathological features,molecular subtypes and prognosis of breast cancer between young and elderly patients.Methods: Fifty-six young patients with breast cancer,18 to 30 years old,and 120 elderly patients with breast cancer,45 to 70 years old,were divided into the young group and elderly group,respectively.The clinical and pathological features,molecular subtypes and prognosis between two groups were compared.Results: The differences of the tumor size,lymph node metastasis,histological grade,molecular subtype and tumor recurrence between two groups were statistically significant(P<0.05 to P<0.01).The triple negative breast cancer occurred most often in young group.Conclusions: The clinical symptom of breast cancer in young patient is concealment,and its prognosis is poor.The clinical and pathological features,subtypes and prognosis of breast cancer in young patients are different from that in the elderly patients,the early diagnosis and treatment of which should be paid attention to.
2014, 39(11): 1494-1496.
Abstract:
Objective: To investigate the risk factors of transient ischemic attack(TIA) evolving into cerebral infarction.Methods: The clinical data of 32 cases with TIA evolving into cerebral infarction(cerebral infarction group) and 97 cases with TIA no-evolving into cerebral infarction(TIA group) within 6 months were statistically analysed.Results: The indicators of hypertension,unstable carotid plaques,diabetes,duration of attack more than or equal to 30 minutes and attack frequency more than or equal to 3 times in cerebral infarction group were higher than those in TIA group(P<0.05 to P<0.01).The differences of sex,smoking history and coronary heart disease between two groups were not statistically significant(P>0.05).The patient age of cerebral infarction group was higher than that in TIA group(P<0.05).The differences of the levels of FBG,triglycerides,cholesterol,LDL and serum uric acid between two groups were not statistically significant(P>0.05).Conclusions: The incidences of TIA evolving into cerebral infarction in the patients with long lasting time and frequent attacking of TIA complicated with hypertension,diabetes,advanced age and unstable carotid plaques are higher.
Objective: To investigate the risk factors of transient ischemic attack(TIA) evolving into cerebral infarction.Methods: The clinical data of 32 cases with TIA evolving into cerebral infarction(cerebral infarction group) and 97 cases with TIA no-evolving into cerebral infarction(TIA group) within 6 months were statistically analysed.Results: The indicators of hypertension,unstable carotid plaques,diabetes,duration of attack more than or equal to 30 minutes and attack frequency more than or equal to 3 times in cerebral infarction group were higher than those in TIA group(P<0.05 to P<0.01).The differences of sex,smoking history and coronary heart disease between two groups were not statistically significant(P>0.05).The patient age of cerebral infarction group was higher than that in TIA group(P<0.05).The differences of the levels of FBG,triglycerides,cholesterol,LDL and serum uric acid between two groups were not statistically significant(P>0.05).Conclusions: The incidences of TIA evolving into cerebral infarction in the patients with long lasting time and frequent attacking of TIA complicated with hypertension,diabetes,advanced age and unstable carotid plaques are higher.
2014, 39(11): 1497-1500.
Abstract:
Objective: To explore the clinical characteristics and efficacy of different therapies for malignant lymphoma of the nasal sinus,and to provide scientific evidence for clinical management of the disease.Methods: Among the 70 patients with nasal sinus malignant lymphoma,42 patients underwent radiotherapy and chemotherapy,and 28 patients received radiotherapy only.Most of the patients were administered CHOP as their chemotherapy regimen,and the others received B-CHOP.Those who received local radio-therapy were performed the linear accelerator irradiation,and the radiological dose was 40~60 Gy for 3~5 weeks.The patients' clinical symptoms,signs,imaging information,biochemistry,pathology,treatment and prognostic factors were analyzed.Results: Of the 70 patients,51 were male(72.9%) and 19 female(27.1%);56 patients were at stageⅠe and stage Ⅱe(80.0%),and 55 patients had single nasal lesion(78.6%).T cell type was the major pathological classification;the main manifestations were stuffy nose,runny nose,swelling,epistaxis,oral and eye symptoms and even complaints in the neck.40 patients survived for 5 years without suffering,and the disease-free survival rate(DFR) was 57.1%.In the 5-year DFR,30 patients received both radiotherapy and chemotherapy,and 10 patients received chemotherapy only,with a DFR rate of 71.4% and 35.7%,respectively;The difference was statistically significant(P<0.01).In the patients at stage Ⅰe,21 cases received both radiotherapy and chemotherapy survived for 5 years and 10 cases received only radiotherapy survived for 5 years,with a DFR rate of 87.5% and 55.6%,respectively.The difference was statistically significant(P<0.05).7 patients at stage Ⅱe who received radiotherapy and chemotherapy survived for 5 years,while only 2 patients at stage Ⅲe～Ⅳ survived;the difference was not statistically significant(P>0.05).No patients at stage Ⅱe or Ⅲe～Ⅳ survived for 5 years among those who had received radiotherapy only.Conclusions: The clinical staging and treatment methods are the main factors affecting the 5-year DFR.The CHOP combined with radiotherapy could make a better prognosis,and significantly improve the 5-year DFR in patients with malignant lymphoma of the nasal cavity and paranasal sinuses.
Objective: To explore the clinical characteristics and efficacy of different therapies for malignant lymphoma of the nasal sinus,and to provide scientific evidence for clinical management of the disease.Methods: Among the 70 patients with nasal sinus malignant lymphoma,42 patients underwent radiotherapy and chemotherapy,and 28 patients received radiotherapy only.Most of the patients were administered CHOP as their chemotherapy regimen,and the others received B-CHOP.Those who received local radio-therapy were performed the linear accelerator irradiation,and the radiological dose was 40~60 Gy for 3~5 weeks.The patients' clinical symptoms,signs,imaging information,biochemistry,pathology,treatment and prognostic factors were analyzed.Results: Of the 70 patients,51 were male(72.9%) and 19 female(27.1%);56 patients were at stageⅠe and stage Ⅱe(80.0%),and 55 patients had single nasal lesion(78.6%).T cell type was the major pathological classification;the main manifestations were stuffy nose,runny nose,swelling,epistaxis,oral and eye symptoms and even complaints in the neck.40 patients survived for 5 years without suffering,and the disease-free survival rate(DFR) was 57.1%.In the 5-year DFR,30 patients received both radiotherapy and chemotherapy,and 10 patients received chemotherapy only,with a DFR rate of 71.4% and 35.7%,respectively;The difference was statistically significant(P<0.01).In the patients at stage Ⅰe,21 cases received both radiotherapy and chemotherapy survived for 5 years and 10 cases received only radiotherapy survived for 5 years,with a DFR rate of 87.5% and 55.6%,respectively.The difference was statistically significant(P<0.05).7 patients at stage Ⅱe who received radiotherapy and chemotherapy survived for 5 years,while only 2 patients at stage Ⅲe～Ⅳ survived;the difference was not statistically significant(P>0.05).No patients at stage Ⅱe or Ⅲe～Ⅳ survived for 5 years among those who had received radiotherapy only.Conclusions: The clinical staging and treatment methods are the main factors affecting the 5-year DFR.The CHOP combined with radiotherapy could make a better prognosis,and significantly improve the 5-year DFR in patients with malignant lymphoma of the nasal cavity and paranasal sinuses.
2014, 39(11): 1500-1502.
Abstract:
Objective: To investigate the influence of dexmedetomidine on patient-controlled intravenous analgesia(PCIA)with fentanil after thoracic surgery.Methods: Forty ASAⅠ-Ⅲ patients scheduled for elective thoracic surgery were randomly divided into two groups(n=20,each)according to the PCIA formula.Group C received fentanil 20 μg/kg and group D fentanil 20 μg/kg plus dexmedetomidine 10 μg/kg;and the PCIA was diluted with 100 saline.The initial loading volume was 2 ml,background volume 2 ml/h and bolus dose 0.5 ml;the lockout time was set to 15 min.The number of the pressing attempts,consumption of fentanil within 24 h,the visual analogue scales,and the Ramsay sedation scale at 4,8,24 and 48 h after surgery were recorded;the incidence of vomiting and respiration depression was also recorded.Blood samples were obtained before anesthesia,4,8 and 24 h after surgery for determination of serum cortisol concentration.The patients' satisfactory degree was evaluated 48 h after surgery.Results: Compared to group C,group D had a decreased number of PCIA pressing attempts and consumption of fentanil within 24 h after operation(P<0.01);the Ramsay sedation scale of group D increased at 4,8,24 and 48 h after surgery;the visual analogue scales of group D decreased at 4 and 8 hour after surgery(P<0.01 to P<0.05).The incidence of respiratory inhibition vomiting and serum cortisol concentration after operation had no significant differences between the two groups(P>0.05).The satisfaction degree of the patients in group D was significantly higher than that in group C(P<0.05).Conclusions: The effect of combination use of dexmedetomidine and fentanil is superior to fentanil alone in PCIA after thoracic surgery.
Objective: To investigate the influence of dexmedetomidine on patient-controlled intravenous analgesia(PCIA)with fentanil after thoracic surgery.Methods: Forty ASAⅠ-Ⅲ patients scheduled for elective thoracic surgery were randomly divided into two groups(n=20,each)according to the PCIA formula.Group C received fentanil 20 μg/kg and group D fentanil 20 μg/kg plus dexmedetomidine 10 μg/kg;and the PCIA was diluted with 100 saline.The initial loading volume was 2 ml,background volume 2 ml/h and bolus dose 0.5 ml;the lockout time was set to 15 min.The number of the pressing attempts,consumption of fentanil within 24 h,the visual analogue scales,and the Ramsay sedation scale at 4,8,24 and 48 h after surgery were recorded;the incidence of vomiting and respiration depression was also recorded.Blood samples were obtained before anesthesia,4,8 and 24 h after surgery for determination of serum cortisol concentration.The patients' satisfactory degree was evaluated 48 h after surgery.Results: Compared to group C,group D had a decreased number of PCIA pressing attempts and consumption of fentanil within 24 h after operation(P<0.01);the Ramsay sedation scale of group D increased at 4,8,24 and 48 h after surgery;the visual analogue scales of group D decreased at 4 and 8 hour after surgery(P<0.01 to P<0.05).The incidence of respiratory inhibition vomiting and serum cortisol concentration after operation had no significant differences between the two groups(P>0.05).The satisfaction degree of the patients in group D was significantly higher than that in group C(P<0.05).Conclusions: The effect of combination use of dexmedetomidine and fentanil is superior to fentanil alone in PCIA after thoracic surgery.
2014, 39(11): 1503-1505.
Abstract:
Objective: To evaluate the efficacy of testosterone undecanoate combined with tadalafil(TUT) in the treatment of type 2 diabetic erectile dysfunction(DED) for providing a new treatment way.Methods: One hundred and fifteen patients with DED were treated with TUT for 3 months.The score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level in all patients before and after treatment were compared.Results: Compared with before treatment,the score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level of patients were obviously improved after treatment(P<0.01).Conclusions: TUT therapy is safe,effective and less adverse reaction,which can significantly improve the quality of sex life of patients,and is worthy of promotion.
Objective: To evaluate the efficacy of testosterone undecanoate combined with tadalafil(TUT) in the treatment of type 2 diabetic erectile dysfunction(DED) for providing a new treatment way.Methods: One hundred and fifteen patients with DED were treated with TUT for 3 months.The score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level in all patients before and after treatment were compared.Results: Compared with before treatment,the score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level of patients were obviously improved after treatment(P<0.01).Conclusions: TUT therapy is safe,effective and less adverse reaction,which can significantly improve the quality of sex life of patients,and is worthy of promotion.
2014, 39(11): 1505-1507.
Abstract:
Objective: To observe the anticoagulant effect of warfarin in the treatment of elderly patients with type 2 diabetes complicated with atrial fibrillation.Methods: One hundred and thirty-two diabetic patients complicated with atrial fibrillation with the age over 75 were divided into warfarin moderate intensity group[international normalized ratio(INR) was maintained at 2.1-2.5],warfarin low intensity group INR was maintained at 1.5-2.0 and control group(aspirin),each group consisting of 44 cases.All the cases were followed up for 1 year.The incidence of thromboembolism and bleeding events were recorded.Results: The incidence of thromboembolic events tended to increase in the moderate intensity group,low intensity group and control group;the incidence of thromboembolism in the control group was higher than that in the warfarin moderate intensity group and low intensity group(P<0.05);the difference in the thrombembolia rate had no statistical significance between the moderate intensity group and the low intensity group(P>0.05).The bleeding events tended to reduce in the moderate intensity group,low intensity group and control group;the bleeding rate of the moderate intensity group was higher than that of the low intensity group and the control group(P<0.05);but the bleeding rate in the control group had no statistical significance compared with that in the low intensity group(P>0.05).Conclusions: warfarin is effective on senile diabetic patients complicated with atrial fibrillation when the INR value is maintained at 1.5-2.0,which may achieve the best anticoagulant effect and avoid the occurrence of bleeding events.
Objective: To observe the anticoagulant effect of warfarin in the treatment of elderly patients with type 2 diabetes complicated with atrial fibrillation.Methods: One hundred and thirty-two diabetic patients complicated with atrial fibrillation with the age over 75 were divided into warfarin moderate intensity group[international normalized ratio(INR) was maintained at 2.1-2.5],warfarin low intensity group INR was maintained at 1.5-2.0 and control group(aspirin),each group consisting of 44 cases.All the cases were followed up for 1 year.The incidence of thromboembolism and bleeding events were recorded.Results: The incidence of thromboembolic events tended to increase in the moderate intensity group,low intensity group and control group;the incidence of thromboembolism in the control group was higher than that in the warfarin moderate intensity group and low intensity group(P<0.05);the difference in the thrombembolia rate had no statistical significance between the moderate intensity group and the low intensity group(P>0.05).The bleeding events tended to reduce in the moderate intensity group,low intensity group and control group;the bleeding rate of the moderate intensity group was higher than that of the low intensity group and the control group(P<0.05);but the bleeding rate in the control group had no statistical significance compared with that in the low intensity group(P>0.05).Conclusions: warfarin is effective on senile diabetic patients complicated with atrial fibrillation when the INR value is maintained at 1.5-2.0,which may achieve the best anticoagulant effect and avoid the occurrence of bleeding events.
2014, 39(11): 1508-1511,1514.
Abstract:
Objective: To study the clinical efficacy of biological immune therapy of dendritic cell(DC) or cytokine-induced killers cell(CIK) combined with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC) by using Meta-analysis and systematic review of the literature.Methods: Randomized controlled trials(RCT) papers were searched in China Academic Journals,China National Knowledge Infrastructure,WeiPu and Wanfang database,PubMed and CBM foreign database.Jadad scale was used to devalue the quality of the included papers;Meta-analysis of the clinical efficacy,the life quality and the immunologic function(CD3+、CD4+、CD4+/CD8+) was performed with Revman 4.2 software.Results: Eleven RCT papers were included after screening,and the quality of the papers obtained low Jadad score.Meta-analysis showed that the odds ratio(OR) of the combined clinical benefit rate was 2.45,95% CI 1.56 to 3.83;the OR of the life quality was 3.17,95%CI 1.82 to 5.52.After treatment,the levels of CD3+ in the immunotherapy group increased to 16.96,95%CI 14.09 to 17.82,the levels of CD4+ increased to 6.84,95%CI 6.06 to 8.63 and the levels of CD4+/CD8+ increased to 0.60,95%CI 0.56 to 0.65.The clinical benefit rate and the immunologic function rate of the DC-CIK therapy or CIK combined with chemotherapy were superior to those of the control in the treatment of NSCLC.Conclusions: Biological immune therapy of DC-CIK or CIK combined with chemotherapy can help to improve the clinical benefit rate,the life quality and immunologic function of the patients with advanced NSCLC.
Objective: To study the clinical efficacy of biological immune therapy of dendritic cell(DC) or cytokine-induced killers cell(CIK) combined with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC) by using Meta-analysis and systematic review of the literature.Methods: Randomized controlled trials(RCT) papers were searched in China Academic Journals,China National Knowledge Infrastructure,WeiPu and Wanfang database,PubMed and CBM foreign database.Jadad scale was used to devalue the quality of the included papers;Meta-analysis of the clinical efficacy,the life quality and the immunologic function(CD3+、CD4+、CD4+/CD8+) was performed with Revman 4.2 software.Results: Eleven RCT papers were included after screening,and the quality of the papers obtained low Jadad score.Meta-analysis showed that the odds ratio(OR) of the combined clinical benefit rate was 2.45,95% CI 1.56 to 3.83;the OR of the life quality was 3.17,95%CI 1.82 to 5.52.After treatment,the levels of CD3+ in the immunotherapy group increased to 16.96,95%CI 14.09 to 17.82,the levels of CD4+ increased to 6.84,95%CI 6.06 to 8.63 and the levels of CD4+/CD8+ increased to 0.60,95%CI 0.56 to 0.65.The clinical benefit rate and the immunologic function rate of the DC-CIK therapy or CIK combined with chemotherapy were superior to those of the control in the treatment of NSCLC.Conclusions: Biological immune therapy of DC-CIK or CIK combined with chemotherapy can help to improve the clinical benefit rate,the life quality and immunologic function of the patients with advanced NSCLC.
2014, 39(11): 1512-1514.
Abstract:
Objective: To observe the short-term effects and adverse reactions of the gimeracil and oteracil porassium capsule(S-1) or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer.Methods: Forty-eight patients with advanced gastric cancer were randomly divided into the S-1 group and capecitabine group.The S-1 group were treated with 60 mg of gimeracil and oteracil porassium capsule(the body surface area more than or equal 1.25 m2) twice a day for 14 days,3 weeks for a schedule.The capecitabine group were treated with 1 250 mg/m2 of capecitabine twice a day for 14 days,3 weeks for a schedule.The 85 mg/m2 of oxaliplatin were administered in two groups on the first day.The efficacy was evaluated by CT scan after 2 cycles.Results: The effective rates and tumor growth control rates in S-1 group and capecitabine group were 62.5% ＆ 79.2% and 58.3% ＆ 83.3%,respectively.The differences of effects and adverse reactions between two groups were not statistical significance(P>0.05).The blood platelet decreasing 3 to 4 grade in S-1 group and hemameba decreasing 3 to 4 grade in capecitabine group were found.The less side effects,good tolerance and no death case were observed.Conclusions: The gimeracil and oteracil porassium capsule or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer is good effect and less adverse reactions.
Objective: To observe the short-term effects and adverse reactions of the gimeracil and oteracil porassium capsule(S-1) or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer.Methods: Forty-eight patients with advanced gastric cancer were randomly divided into the S-1 group and capecitabine group.The S-1 group were treated with 60 mg of gimeracil and oteracil porassium capsule(the body surface area more than or equal 1.25 m2) twice a day for 14 days,3 weeks for a schedule.The capecitabine group were treated with 1 250 mg/m2 of capecitabine twice a day for 14 days,3 weeks for a schedule.The 85 mg/m2 of oxaliplatin were administered in two groups on the first day.The efficacy was evaluated by CT scan after 2 cycles.Results: The effective rates and tumor growth control rates in S-1 group and capecitabine group were 62.5% ＆ 79.2% and 58.3% ＆ 83.3%,respectively.The differences of effects and adverse reactions between two groups were not statistical significance(P>0.05).The blood platelet decreasing 3 to 4 grade in S-1 group and hemameba decreasing 3 to 4 grade in capecitabine group were found.The less side effects,good tolerance and no death case were observed.Conclusions: The gimeracil and oteracil porassium capsule or capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer is good effect and less adverse reactions.
2014, 39(11): 1515-1517,1520.
Abstract:
Objective: To discuss the effect of the core stability training combined with alternating electromagnetic field therapy for treatment of central coordination disorder.Methods: Ninety-five children with central coordination disorder of the spastic type were randomly divided into four groups:traditional group(n=23 cases),observation group(n=26 cases),training group(n=24 cases) and alternating electromagnetic field(EMF) group(n=22 cases).The children in the traditional group were given only the routine rehabilitation training;the observation group received the core stability training combined with alternating electromagnetic field therapy,the training group received the core stability training and the EMF group received the alternating electromagnetic field therapy,all in addition to the routine rehabilitation training.The effect was evaluated by Bayley motor development index(PDI) and motor function.Results: The PDI of the observation group was significantly higher than that of the training group and the EMF group(P<0.01);the PDI of the training group and the electromagnetic field group was significantly higher than that of the traditional group(P<0.01).The follow- up results showed that the motor function index of the observation group was significantly higher than that of the traditional group(P<0.01);The rates of normal head-raising in the training group and normal popliteal angle in the electromagnetic field group were higher than those in the traditional group(P<0.01).Conclusions: Traditional rehabilitation therapy in combination with core stability training and alternating electromagnetic field therapy is more effective than traditional rehabilitation therapy alone in treatment of central coordination disorder.
Objective: To discuss the effect of the core stability training combined with alternating electromagnetic field therapy for treatment of central coordination disorder.Methods: Ninety-five children with central coordination disorder of the spastic type were randomly divided into four groups:traditional group(n=23 cases),observation group(n=26 cases),training group(n=24 cases) and alternating electromagnetic field(EMF) group(n=22 cases).The children in the traditional group were given only the routine rehabilitation training;the observation group received the core stability training combined with alternating electromagnetic field therapy,the training group received the core stability training and the EMF group received the alternating electromagnetic field therapy,all in addition to the routine rehabilitation training.The effect was evaluated by Bayley motor development index(PDI) and motor function.Results: The PDI of the observation group was significantly higher than that of the training group and the EMF group(P<0.01);the PDI of the training group and the electromagnetic field group was significantly higher than that of the traditional group(P<0.01).The follow- up results showed that the motor function index of the observation group was significantly higher than that of the traditional group(P<0.01);The rates of normal head-raising in the training group and normal popliteal angle in the electromagnetic field group were higher than those in the traditional group(P<0.01).Conclusions: Traditional rehabilitation therapy in combination with core stability training and alternating electromagnetic field therapy is more effective than traditional rehabilitation therapy alone in treatment of central coordination disorder.
2014, 39(11): 1518-1520.
Abstract:
Objective: To observe the problems in endotracheal intubation teaching and the incidence of postoperative sore throat and hoarseness so as to improve the teaching quality of intubation.Methods: One hundred patients undergoing general anesthesia were randomized into teaching group(n=50) and anesthetist group(n=50).The time length of intubation,incidence of deoxygenation and number of intubating attempts were recorded in both groups.The postoperative sore throat and hoarseness were also assessed when the patients departed from the Postanesthesia care unif and 24 hours after the operation.Results: The time length of intubation,incidence of deoxygenation and number of intubating attempts in the teaching group were significantly higher than those in the anesthetist group(P<0.01);the severity of sore throat was significantly less in the anesthetist group than that in the teaching group(P<0.01);however,there was no significant difference in the incidence of hoarseness between the two groups(P>0.05).Conclusions: Endotracheal intubation teaching will extend the time length of intubation,increase the number of intubating attempts and increase the risk of airway injuries.
Objective: To observe the problems in endotracheal intubation teaching and the incidence of postoperative sore throat and hoarseness so as to improve the teaching quality of intubation.Methods: One hundred patients undergoing general anesthesia were randomized into teaching group(n=50) and anesthetist group(n=50).The time length of intubation,incidence of deoxygenation and number of intubating attempts were recorded in both groups.The postoperative sore throat and hoarseness were also assessed when the patients departed from the Postanesthesia care unif and 24 hours after the operation.Results: The time length of intubation,incidence of deoxygenation and number of intubating attempts in the teaching group were significantly higher than those in the anesthetist group(P<0.01);the severity of sore throat was significantly less in the anesthetist group than that in the teaching group(P<0.01);however,there was no significant difference in the incidence of hoarseness between the two groups(P>0.05).Conclusions: Endotracheal intubation teaching will extend the time length of intubation,increase the number of intubating attempts and increase the risk of airway injuries.
2014, 39(11): 1521-1523,1527.
Abstract:
Objective: To explore the clinical significance of the joint detection of carbohydrate antigen 125(CA125) and adenosine deaminase(ADA) in hydrothorax in the diagnosis of tuberculous pleurisy.Methods: The levels of CA125 and ADA in hydrothorax of 54 patients with tuberculous pleurisy and 40 patients with malignant pleural effusion were measured using electrochemiluminescence assay.The four tumor markers(including carcino embryonic antigen,CA199,neuron-specific enolase,cylokerain fragments21-1 were also detected.Results: The concentrations of CA125 and ADA in hydrothorax of tuberculous pleurisy were(702.67 ± 367.30)u/ml and(81.74±18.82)u/L,respectively,whose were higher than the normal level.The sensitivity of CA125(100.0%) was higher than that of ADA(88.9%) in hydrothorax.The positive rates of four tumor markers were low.The sensitivity and specificity of the joint detection of CA125 and ADA could be increased to 88.9% and 90.75%,respectively.Conclusions: The measurement of CA125 is beneficial in the diagnosis of tuberculous pleurisy.The combined detection of CA125 and ADA can improve the diagnostic positive rate of tuberculous pleurisy,combined other tumor indexes detection can help to exclude malignant pleural effusion.
Objective: To explore the clinical significance of the joint detection of carbohydrate antigen 125(CA125) and adenosine deaminase(ADA) in hydrothorax in the diagnosis of tuberculous pleurisy.Methods: The levels of CA125 and ADA in hydrothorax of 54 patients with tuberculous pleurisy and 40 patients with malignant pleural effusion were measured using electrochemiluminescence assay.The four tumor markers(including carcino embryonic antigen,CA199,neuron-specific enolase,cylokerain fragments21-1 were also detected.Results: The concentrations of CA125 and ADA in hydrothorax of tuberculous pleurisy were(702.67 ± 367.30)u/ml and(81.74±18.82)u/L,respectively,whose were higher than the normal level.The sensitivity of CA125(100.0%) was higher than that of ADA(88.9%) in hydrothorax.The positive rates of four tumor markers were low.The sensitivity and specificity of the joint detection of CA125 and ADA could be increased to 88.9% and 90.75%,respectively.Conclusions: The measurement of CA125 is beneficial in the diagnosis of tuberculous pleurisy.The combined detection of CA125 and ADA can improve the diagnostic positive rate of tuberculous pleurisy,combined other tumor indexes detection can help to exclude malignant pleural effusion.
2014, 39(11): 1524-1527.
Abstract:
Objective: To observe the effect of parecoxib sodium on the level of plasma prostaglandin E2(PGE2) and β-endorphine(β-EP),and to explore the mechanism related to parecoxib sodium alleviating postoperative acute pain in patients with lower limb fracture undergoing remifentanil anesthesia.Methods: Sixty inpatients undergoing lower limbs fracture were randomly assigned into 3 groups.The patients in group A received a preoperative dose of normal saline 10 ml by intravenous administration.Group B received a preoperative dose of parecoxib sodium 40 mg(saline 10 ml) by intravenous administration before the operation.Group C received parecoxib sodium 40 mg before the operation,and received parecoxib sodium 40 mg every 12 h till 48 h after operation.Patient controlled intravenous analgesia was started 30 min before the end of operation,with the model(load volume 5 ml,continuous infusion at 1.5 ml/h,and bolus 0.5 ml at locked time 10 min).Analgesia mixture was consisted of fentanyl 15 μg/kg(total volume 100 ml).Visual analogue scale was recorded at 1,12,24,48 h after the operation.Valid/invalid presses,the need for additional analgesia drug within 48 h after the operation were recorded.The concentration of PGE2 and β-EP were determined at before anesthesia induction(T1),1 hour after the operation(T2),24 hours after the operation(T3),48 hours after the operation(T4).Results: The patients among three groups were not significantly different in demographics and doses of narcotic(P>0.05).Compared with group A,Visual analogue scale scores in group B and group C significantly decreased.Presses in Patient controlled intravenous analgesia in group C were least in three groups(P<0.05).Plasma PGE2 in group B and C at T2,T3,T4 significantly decreased than group A(P<0.05 to P<0.01).Plasma β-EP in group C at T3,T4 were higher than that in group A and B(P<0.05 to P<0.01).Conclusions: Parecoxib sodium could heighten the effect of opioids,and significantly relieve the postoperative acute pain in patients with lower limb fracture undergoing remifentanil anesthesia.The underlying mechanism may be related to release of endogenous β-EP and inhibition of PGE2 release.
Objective: To observe the effect of parecoxib sodium on the level of plasma prostaglandin E2(PGE2) and β-endorphine(β-EP),and to explore the mechanism related to parecoxib sodium alleviating postoperative acute pain in patients with lower limb fracture undergoing remifentanil anesthesia.Methods: Sixty inpatients undergoing lower limbs fracture were randomly assigned into 3 groups.The patients in group A received a preoperative dose of normal saline 10 ml by intravenous administration.Group B received a preoperative dose of parecoxib sodium 40 mg(saline 10 ml) by intravenous administration before the operation.Group C received parecoxib sodium 40 mg before the operation,and received parecoxib sodium 40 mg every 12 h till 48 h after operation.Patient controlled intravenous analgesia was started 30 min before the end of operation,with the model(load volume 5 ml,continuous infusion at 1.5 ml/h,and bolus 0.5 ml at locked time 10 min).Analgesia mixture was consisted of fentanyl 15 μg/kg(total volume 100 ml).Visual analogue scale was recorded at 1,12,24,48 h after the operation.Valid/invalid presses,the need for additional analgesia drug within 48 h after the operation were recorded.The concentration of PGE2 and β-EP were determined at before anesthesia induction(T1),1 hour after the operation(T2),24 hours after the operation(T3),48 hours after the operation(T4).Results: The patients among three groups were not significantly different in demographics and doses of narcotic(P>0.05).Compared with group A,Visual analogue scale scores in group B and group C significantly decreased.Presses in Patient controlled intravenous analgesia in group C were least in three groups(P<0.05).Plasma PGE2 in group B and C at T2,T3,T4 significantly decreased than group A(P<0.05 to P<0.01).Plasma β-EP in group C at T3,T4 were higher than that in group A and B(P<0.05 to P<0.01).Conclusions: Parecoxib sodium could heighten the effect of opioids,and significantly relieve the postoperative acute pain in patients with lower limb fracture undergoing remifentanil anesthesia.The underlying mechanism may be related to release of endogenous β-EP and inhibition of PGE2 release.
2014, 39(11): 1528-1530,1533.
Abstract:
Objective: To explore the effect of rosuvastatin on the blood lipid and neurofunctional of patients with arteriosclerotic cerebral infarction.Methods: Sixty-two patients with cerebral infarction were divided into observation group and control group by a prospective randomized open method.Conventional therapy such as anticoagulants,dehydrating agent and drugs to improve the microcirculation was applied to all the patients;and the patients in the observation group were administered statin rosuvastatin calcium tablets in addition to the routine therapy.The blood lipid,nerve function,carotid intima - media thickness(IMT) and the infarct size were compared between the two groups before treatment,3,6 and 12 months after treatment.Results: Compared with the control group,the TC,TG and LDL of the observation group decreased(P<0.01),the HDL increased(P<0.01),the IMT diminished(P<0.01) and the nerve function improved significantly after 12 months of treatment(P<0.01).Before treatment,the infarct area had no significant difference between the two groups(P>0.05);after treatment,the infarct area in the two groups diminished significantly.After 12 months of therapy,3 cases of large area of infarct and 7 cases of small area of infarct in the observation group improved(41.2%),and 1 case of large area of infarct and 4 cases of mall area of infarct in the control group improved(22.2%).The difference in the infarct area was not statistically significant after treatment for 3 months,6 months or 12 months(P>0.05).Conclusions: Rosuvastatin can significantly improve the cerebral blood lipid and nerve function,decrease the adverse reactions and improve the clinical outcome of patients with cerebral infarction.
Objective: To explore the effect of rosuvastatin on the blood lipid and neurofunctional of patients with arteriosclerotic cerebral infarction.Methods: Sixty-two patients with cerebral infarction were divided into observation group and control group by a prospective randomized open method.Conventional therapy such as anticoagulants,dehydrating agent and drugs to improve the microcirculation was applied to all the patients;and the patients in the observation group were administered statin rosuvastatin calcium tablets in addition to the routine therapy.The blood lipid,nerve function,carotid intima - media thickness(IMT) and the infarct size were compared between the two groups before treatment,3,6 and 12 months after treatment.Results: Compared with the control group,the TC,TG and LDL of the observation group decreased(P<0.01),the HDL increased(P<0.01),the IMT diminished(P<0.01) and the nerve function improved significantly after 12 months of treatment(P<0.01).Before treatment,the infarct area had no significant difference between the two groups(P>0.05);after treatment,the infarct area in the two groups diminished significantly.After 12 months of therapy,3 cases of large area of infarct and 7 cases of small area of infarct in the observation group improved(41.2%),and 1 case of large area of infarct and 4 cases of mall area of infarct in the control group improved(22.2%).The difference in the infarct area was not statistically significant after treatment for 3 months,6 months or 12 months(P>0.05).Conclusions: Rosuvastatin can significantly improve the cerebral blood lipid and nerve function,decrease the adverse reactions and improve the clinical outcome of patients with cerebral infarction.
2014, 39(11): 1531-1533.
Abstract:
Objective: To evaluate the value of endoscopic ultrasonography(EUS) in the preoperative TN staging of gastric cancer,and to improve its diagnostic level.Methods: The preoperative TN staging of gastric cancer diagnosed by pathology in 133 patients were identified by EUS,which was compared with the postoperative histopathological stage.Results: The overall accuracy rate of preoperative T staging of gastric cancer detected by EUS was 81.20%.The accuracy of T1 and T4 were high,whose were 91.67% and 85.0%,the accuracy of T2 and T3 were low,whose were 74.29% and 70.0%,respectively.There were too deep or too shallow phenomenon in the T staging,too deep in 8 cases and too shallow in 17 cases were found.The preoperative staging of gastric cancer detected by EUS was highly consistent with the postoperatively pathological staging(P<0.01).The overall accuracy rate of N staging identified by EUS was 78.95%,the accuracy rate of positive and negative lymph node were 66.10% and 89.19%,respectively,the differences of whose compared with the postoperatively pathological staging were statistically significant(P<0.05).Conclusions: Endoscopic ultrasonography can accurately identified the TN staging of gastric cancer,which can provide the basis in formulating the reasonable treatment.
Objective: To evaluate the value of endoscopic ultrasonography(EUS) in the preoperative TN staging of gastric cancer,and to improve its diagnostic level.Methods: The preoperative TN staging of gastric cancer diagnosed by pathology in 133 patients were identified by EUS,which was compared with the postoperative histopathological stage.Results: The overall accuracy rate of preoperative T staging of gastric cancer detected by EUS was 81.20%.The accuracy of T1 and T4 were high,whose were 91.67% and 85.0%,the accuracy of T2 and T3 were low,whose were 74.29% and 70.0%,respectively.There were too deep or too shallow phenomenon in the T staging,too deep in 8 cases and too shallow in 17 cases were found.The preoperative staging of gastric cancer detected by EUS was highly consistent with the postoperatively pathological staging(P<0.01).The overall accuracy rate of N staging identified by EUS was 78.95%,the accuracy rate of positive and negative lymph node were 66.10% and 89.19%,respectively,the differences of whose compared with the postoperatively pathological staging were statistically significant(P<0.05).Conclusions: Endoscopic ultrasonography can accurately identified the TN staging of gastric cancer,which can provide the basis in formulating the reasonable treatment.
2014, 39(11): 1534-1536.
Abstract:
Objective: To investigate the clinical efficacy of azithromycin combined with vitamin D in the treatment of asthma of children.Methods: Ninety children with bronchial asthma were randomly divided into the conventional therapy group(group A),Azithromycin group(group B) and azithromycin combined with vitamin D group(group C).The concentrations of serum interleukin(IL)-2 and IL-17 in all patients were measured before and after the treatment.The blood parameters,the time of symptoms and signs improvement and hospital stays between 3 groups were compared before and after the treatment.Results: The differences of serum IL-2 and IL-17 levels between 3 groups before treatment were not statistically significant(P>0.05).After the treatment,the levels of serum IL-2 and IL-17 in 3 groups increased and decreased,respectively(P<0.01),especially for group C(P<0.05 to P<0.01).The time of symptoms and signs improvement and hospital stays in group C were shorter than those in group A and B(P<0.05 to P<0.01).Conclusions: The treatment of azithromycin combined with vitamin D can improve the airway inflammation,body's resistance and clinical efficacy in children.
Objective: To investigate the clinical efficacy of azithromycin combined with vitamin D in the treatment of asthma of children.Methods: Ninety children with bronchial asthma were randomly divided into the conventional therapy group(group A),Azithromycin group(group B) and azithromycin combined with vitamin D group(group C).The concentrations of serum interleukin(IL)-2 and IL-17 in all patients were measured before and after the treatment.The blood parameters,the time of symptoms and signs improvement and hospital stays between 3 groups were compared before and after the treatment.Results: The differences of serum IL-2 and IL-17 levels between 3 groups before treatment were not statistically significant(P>0.05).After the treatment,the levels of serum IL-2 and IL-17 in 3 groups increased and decreased,respectively(P<0.01),especially for group C(P<0.05 to P<0.01).The time of symptoms and signs improvement and hospital stays in group C were shorter than those in group A and B(P<0.05 to P<0.01).Conclusions: The treatment of azithromycin combined with vitamin D can improve the airway inflammation,body's resistance and clinical efficacy in children.
The clinical significance of von willebrand factor antigen detection in patients with acute leukemia
2014, 39(11): 1557-1558,1561.
Abstract:
Objective: To explore the clinical meaning of von willebrand factor antigen (vWF:Ag) detection in patients with acute leukemia.Methods: The levels of vWF:Ag,D-dimer and fibrin/fibrinogen degradation products(FDPs) were detected by CA-7000 coagulation analyzer,the levels of lactate dehydrogenase(LDH) and high sensitive C-reactive protein(hs-CRP) were detected by 7600 automated biochemistry analyzer,the complete blood counts were tested by Mindray 6 800 hematology analyzer in 39 patients with acute leukemia(including 15 cases with WBC>50×109 /L and 24 cases with <50×109/L) and 21 normal controls.Results: Compared with the control group,the levels of vWF:Ag,D-dimer,FDPs,LDH and hs-CRP were higher in acute leukemia patients(P<0.01),the levels of vWF:Ag and LDH were higher in acute leukemia patients with WBC>50×109 /L than those with WBC<50×109/L(P<0.05 and P<0.01),vWF:Ag had the positive correlations with D-dimer,FDPs,LDH and hs-CRP.Conclusions: The endothelial cell injury was happened in patients with acute leukemia,which presented as the increase of vWF:Ag,the manifestation was correlated with tumor load,acute phase response and hyperfibrinolysis.
Objective: To explore the clinical meaning of von willebrand factor antigen (vWF:Ag) detection in patients with acute leukemia.Methods: The levels of vWF:Ag,D-dimer and fibrin/fibrinogen degradation products(FDPs) were detected by CA-7000 coagulation analyzer,the levels of lactate dehydrogenase(LDH) and high sensitive C-reactive protein(hs-CRP) were detected by 7600 automated biochemistry analyzer,the complete blood counts were tested by Mindray 6 800 hematology analyzer in 39 patients with acute leukemia(including 15 cases with WBC>50×109 /L and 24 cases with <50×109/L) and 21 normal controls.Results: Compared with the control group,the levels of vWF:Ag,D-dimer,FDPs,LDH and hs-CRP were higher in acute leukemia patients(P<0.01),the levels of vWF:Ag and LDH were higher in acute leukemia patients with WBC>50×109 /L than those with WBC<50×109/L(P<0.05 and P<0.01),vWF:Ag had the positive correlations with D-dimer,FDPs,LDH and hs-CRP.Conclusions: The endothelial cell injury was happened in patients with acute leukemia,which presented as the increase of vWF:Ag,the manifestation was correlated with tumor load,acute phase response and hyperfibrinolysis.
2014, 39(11): 1559-1561.
Abstract:
Objective: To explore the problems existing in human immunodeficiency virus(HIV) antibody confirmatory testing techniques and the corresponding solutions in practical work by following up one case of false positive conclusion in HIV antibody confirmatory test.Methods: The subject underwent HIV antibody screening and confirmatory testing,and received follow-up testing at the 4th week,8th week and 12th week.In the last two follow-ups,HIV-1 viral load testing was conducted;and in the fourth follow-up,the CD4+ T lymphocytes were detected.Results: The band types of HIV antibody detected by immunoblotting in the four tests were all gp160,gp120 and p24;the viral load results in the last two follow-ups were both TND,and the result of CD4+ T lymphocytes in the fourth test was 885 cells/μl.Combined with epidemiological data,the HIV antibody was ultimately determined to be negative.Conclusions: With the increasing of inconclusive samples by HIV antibody confirmatory test,we must be greatly cautious of the confirmatory positive samples in the borderline state.For certain special samples,testers must combine epidemiological data analysis and follow-up testing to make an accurate test report.
Objective: To explore the problems existing in human immunodeficiency virus(HIV) antibody confirmatory testing techniques and the corresponding solutions in practical work by following up one case of false positive conclusion in HIV antibody confirmatory test.Methods: The subject underwent HIV antibody screening and confirmatory testing,and received follow-up testing at the 4th week,8th week and 12th week.In the last two follow-ups,HIV-1 viral load testing was conducted;and in the fourth follow-up,the CD4+ T lymphocytes were detected.Results: The band types of HIV antibody detected by immunoblotting in the four tests were all gp160,gp120 and p24;the viral load results in the last two follow-ups were both TND,and the result of CD4+ T lymphocytes in the fourth test was 885 cells/μl.Combined with epidemiological data,the HIV antibody was ultimately determined to be negative.Conclusions: With the increasing of inconclusive samples by HIV antibody confirmatory test,we must be greatly cautious of the confirmatory positive samples in the borderline state.For certain special samples,testers must combine epidemiological data analysis and follow-up testing to make an accurate test report.
2014, 39(11): 1562-1564.
Abstract:
Objective: To compare the methods of mechanical mixing and bromelain treatment in handling non-liquefaction semen.Methods: Sixty cases of non-liquefaction semen were taken from the patients in our department and all the sample's volume was ≥1.5 ml after routine examination.Every sample was divided into group A(control group),group B(semen handled by mechanical mixing) and group C(semen treated with bromelain).Human Computer-aided Semen Analysis System of Spain was used to detect the sperm density and motility;at the same time,Eosin Staining was used to detect the sperm viability,and Modified Papanicolaou Staining was employed to analyze the rate of the normal morphology sperm.Results: There was no significant difference among the three groups in the sperm density and viability(P>0.05).The time of semen liquefaction and sperm motility in group B and group C were both significantly higher than those in group A(P<0.01).However,the rate of normal morphology sperm in group B was significantly lower than that in group A and group C(P<0.01).The time of semen liquefaction in group C was significantly shorter than that in group B(P<0.01).Conclusions: Bromelain method is superior to mechanical mixing in handling abnormal liquefaction semen.It can not only shorten the time of semen routine analysis but reduce the semen viscosity,which will avoid sampling error.
Objective: To compare the methods of mechanical mixing and bromelain treatment in handling non-liquefaction semen.Methods: Sixty cases of non-liquefaction semen were taken from the patients in our department and all the sample's volume was ≥1.5 ml after routine examination.Every sample was divided into group A(control group),group B(semen handled by mechanical mixing) and group C(semen treated with bromelain).Human Computer-aided Semen Analysis System of Spain was used to detect the sperm density and motility;at the same time,Eosin Staining was used to detect the sperm viability,and Modified Papanicolaou Staining was employed to analyze the rate of the normal morphology sperm.Results: There was no significant difference among the three groups in the sperm density and viability(P>0.05).The time of semen liquefaction and sperm motility in group B and group C were both significantly higher than those in group A(P<0.01).However,the rate of normal morphology sperm in group B was significantly lower than that in group A and group C(P<0.01).The time of semen liquefaction in group C was significantly shorter than that in group B(P<0.01).Conclusions: Bromelain method is superior to mechanical mixing in handling abnormal liquefaction semen.It can not only shorten the time of semen routine analysis but reduce the semen viscosity,which will avoid sampling error.
2014, 39(11): 1568-1570.
Abstract:
Objective: To analyze the current situation and trend of equity allocation of general practitioners in Anhui province from 2007 to 2012.Methods: The Lorenz curves and Gini coefficient were used to analyze the equity of population and geographical distribution of general practitioners from 2007 to 2012.The Theil index was used to evaluate the differences of interregional allocation.Results: The Gini coefficient dropped from 0.425 to 0.216 according to the population distribution,and the Gini coefficient dropped from 0.501 to 0.326 according to the geographical distribution.The total difference of Theil index dropped from 0.214 2 to 0.080 1.Conclusions: The currently existing allocation of general practitioners in Anhui province is reasonable;and the equity of population distribution is better than that of geographic distribution.The allocation shows a trend of improvement.
Objective: To analyze the current situation and trend of equity allocation of general practitioners in Anhui province from 2007 to 2012.Methods: The Lorenz curves and Gini coefficient were used to analyze the equity of population and geographical distribution of general practitioners from 2007 to 2012.The Theil index was used to evaluate the differences of interregional allocation.Results: The Gini coefficient dropped from 0.425 to 0.216 according to the population distribution,and the Gini coefficient dropped from 0.501 to 0.326 according to the geographical distribution.The total difference of Theil index dropped from 0.214 2 to 0.080 1.Conclusions: The currently existing allocation of general practitioners in Anhui province is reasonable;and the equity of population distribution is better than that of geographic distribution.The allocation shows a trend of improvement.
2014, 39(11): 1571-1573.
Abstract:
Objective: To investigate the relation of Shanghai elderly hyperlipidemia and fatty liver.Methods: The physical examination data of 524 elderly people from Wuliqiao street community health service center were collected.The relationship between hyperlipidemia and fatty liver in the elderly was analyzed by gender and age,the detection rates of hyperlipidemia and fatty liver of different gender and age were compared.Results: The detection rate of triglycerides in the eldly with fatty liver was higher than that in the eldly without fatty liver(P<0.01).The detection rate of fatty liver in female(63.89%) was higher than that in male(49,5%)(P<0.01).The detection rate of fatty liver in the elderly with high triglycerides was higher than that in the elderly with normal triglycerides(P<0.01).Conclusions: Controlling blood lipid levels can reduce the incidence of fatty liver,and prevent Cardia-cerebrovascular disease
Objective: To investigate the relation of Shanghai elderly hyperlipidemia and fatty liver.Methods: The physical examination data of 524 elderly people from Wuliqiao street community health service center were collected.The relationship between hyperlipidemia and fatty liver in the elderly was analyzed by gender and age,the detection rates of hyperlipidemia and fatty liver of different gender and age were compared.Results: The detection rate of triglycerides in the eldly with fatty liver was higher than that in the eldly without fatty liver(P<0.01).The detection rate of fatty liver in female(63.89%) was higher than that in male(49,5%)(P<0.01).The detection rate of fatty liver in the elderly with high triglycerides was higher than that in the elderly with normal triglycerides(P<0.01).Conclusions: Controlling blood lipid levels can reduce the incidence of fatty liver,and prevent Cardia-cerebrovascular disease
2014, 39(11): 1574-1576.
Abstract:
Objective: To explorethe means of the peripherally inserted central catheter(PICC) through axillary vein and its effects on complications.Methods: One hundred and forty cases treated with PICC through axillary vein and 139 cases through other location were set as the observation group and control groups,respectively.The success rate of once puncture,delivery problem,ectopic rate in the first time and incidence of ectopic correct in place in two groups were compared.Results: The success rates of once puncture and ectopic correct in place in observation group were significantly higher than those in control group(P<0.01).The incidence of piercing difficulty in observation group was obviously lower than that in control group(P<0.01).The difference of the ectopic rate between two groups was not statistically different(P>0.05).Conclusions: Compared with PICC through other location,the PICC through axillary vein can improve the success rates of once puncture and ectopic correct in place and decrease the incidence of piercing difficulty,which is worth popularizing in neonatal PICC.
Objective: To explorethe means of the peripherally inserted central catheter(PICC) through axillary vein and its effects on complications.Methods: One hundred and forty cases treated with PICC through axillary vein and 139 cases through other location were set as the observation group and control groups,respectively.The success rate of once puncture,delivery problem,ectopic rate in the first time and incidence of ectopic correct in place in two groups were compared.Results: The success rates of once puncture and ectopic correct in place in observation group were significantly higher than those in control group(P<0.01).The incidence of piercing difficulty in observation group was obviously lower than that in control group(P<0.01).The difference of the ectopic rate between two groups was not statistically different(P>0.05).Conclusions: Compared with PICC through other location,the PICC through axillary vein can improve the success rates of once puncture and ectopic correct in place and decrease the incidence of piercing difficulty,which is worth popularizing in neonatal PICC.
2014, 39(11): 1577-1579.
Abstract:
Objective: To explore the effects of the eating time on blood pressure of patients during hemodialysis.Methods: The clinical data of 25 patients with hypotension during hemodialysis were investigated using self-control method.The patients were treated with fasting during hemodialysis,eating 250 g food within 2 h of hemodialysis and at 3 h after hemodialysis for 2 weeks,respectively.The mean arterial pressure at 30 min before and after eating,and every hour mean arterial pressure before the hemodialysis and during hemodialysis were analyzed.Results: The differences of mean arterial pressure before and after eating and before the hemodialysis and during hemodialysis,the occurrence rates of hypotension and symptomatic hypotension,and nursing intervention between 3 groups were statistically significant(P<0.01).The differences of all indexes of patients treated with eating at 3 h after hemodialysis and other two groups were statistically significant(P<0.01).The differences of mean arterial pressure before the hemodialysis and number of stop hemodialysis caused by hypotension between 3 groups were not statistically significant(P>0.05).Conclusions: For hypotension-prone patients,the eating time should be within 2 h hours of hemodialysis,and prohibit at 3 h after hemodialysis,which can prevent the hypotension.
Objective: To explore the effects of the eating time on blood pressure of patients during hemodialysis.Methods: The clinical data of 25 patients with hypotension during hemodialysis were investigated using self-control method.The patients were treated with fasting during hemodialysis,eating 250 g food within 2 h of hemodialysis and at 3 h after hemodialysis for 2 weeks,respectively.The mean arterial pressure at 30 min before and after eating,and every hour mean arterial pressure before the hemodialysis and during hemodialysis were analyzed.Results: The differences of mean arterial pressure before and after eating and before the hemodialysis and during hemodialysis,the occurrence rates of hypotension and symptomatic hypotension,and nursing intervention between 3 groups were statistically significant(P<0.01).The differences of all indexes of patients treated with eating at 3 h after hemodialysis and other two groups were statistically significant(P<0.01).The differences of mean arterial pressure before the hemodialysis and number of stop hemodialysis caused by hypotension between 3 groups were not statistically significant(P>0.05).Conclusions: For hypotension-prone patients,the eating time should be within 2 h hours of hemodialysis,and prohibit at 3 h after hemodialysis,which can prevent the hypotension.
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