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2015 Vol. 40, No. 10
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2015, 40(10): 1301-1304.
Abstract:
Objective: To explore the expressions of microRNA(miR)-125b and its target gene semaphorin4C(SEMA4C) in breast cancer tissue(BRCR) and adjacent normal tissue(NCT),and analyze its correlation with clinicopathologic features and significance.Methods: The expressions of miR-125b in 24 BRCR and NCT were detected using Real-time quantitative PCR,and the expressions of SEMA4C in 40 BRCR and NCT were detected by immunohistochemistry.The relationships between the expressions of miR-125b and SEMA4C and clinico-pathological parameters including age,clinical staging,lymph node metastasis,estrogen receptor,progesterone and human epidermal growth factor receptor -2(cerbB-2) were analyzed.Results: The expression of SEMA4C in BRCR was higher than that in NCT,the difference between the expression of SEMA4C and cerbB-2 in lymph node metastasis tissue was statistically significant(P<0.01 and P<0.05).The differences of the age,histological grading,clinical staging,and estrogen and progesterone receptors were not statistically significant(P>0.05).The expression of miR-125b in BRCR was lower than that in NCT(P<0.05),the differences between the expression of SEMA4C and cerbB-2 in lymph node metastasis tissue were statistically significant(P=0.034 to P=0.022).Conclusions: The expressions of miR-125b and SEMA4C in breast invasive ductal carcinoma increase and decrease,respectively,which is associated with lymph node metastasis and cerbB-2 level.The SEMA4C is one target gene of miR-125b,and miR-125b may serve as a potential breast cancer marker.
Objective: To explore the expressions of microRNA(miR)-125b and its target gene semaphorin4C(SEMA4C) in breast cancer tissue(BRCR) and adjacent normal tissue(NCT),and analyze its correlation with clinicopathologic features and significance.Methods: The expressions of miR-125b in 24 BRCR and NCT were detected using Real-time quantitative PCR,and the expressions of SEMA4C in 40 BRCR and NCT were detected by immunohistochemistry.The relationships between the expressions of miR-125b and SEMA4C and clinico-pathological parameters including age,clinical staging,lymph node metastasis,estrogen receptor,progesterone and human epidermal growth factor receptor -2(cerbB-2) were analyzed.Results: The expression of SEMA4C in BRCR was higher than that in NCT,the difference between the expression of SEMA4C and cerbB-2 in lymph node metastasis tissue was statistically significant(P<0.01 and P<0.05).The differences of the age,histological grading,clinical staging,and estrogen and progesterone receptors were not statistically significant(P>0.05).The expression of miR-125b in BRCR was lower than that in NCT(P<0.05),the differences between the expression of SEMA4C and cerbB-2 in lymph node metastasis tissue were statistically significant(P=0.034 to P=0.022).Conclusions: The expressions of miR-125b and SEMA4C in breast invasive ductal carcinoma increase and decrease,respectively,which is associated with lymph node metastasis and cerbB-2 level.The SEMA4C is one target gene of miR-125b,and miR-125b may serve as a potential breast cancer marker.
2015, 40(10): 1305-1308.
Abstract:
Objective: To analyze the expressions of JAKs family-gene in different periods of acute myeloid leukemia(AML) cells,and its correlation with the prognosis of patients.Methods: The mRNA expressions of JAKs family-gene(including JAK1,JAK2,JAK3 and TYK2) in bone marrow MNC of the first-treated group,recurrence group and complete remission group(CR group) and normal control group(NC group) were detected using RT-PCR method.All cases were followed up for 3 years,and the 3-year survival rate was analyzed.Results: The expression levels of the JAK3 and TYK2 mRNA in the first-treated group and recurrence group were higher than those in CR group and NC group(P<0.05 to P<0.01),the differences of the expression level of the JAK2 mRNA in the 4 groups were were statisticallg significant(P<0.05),and the differences of the mRNA expression levels of JAKs family-gene between the first-treated group,recurrence group,CR group and NC group were not statistically significant(P>0.05).The differences of the CR rate in the JAK1,JAK2,JAK3 and TYK2 positive group and negative group were not statistically significant(P>0.05).Kaplan-Meier analysis showed that the 3-year survival rates in the JAK1,JAK2,JAK3 and TYK2 mRNA positive expression groups were 36.75%,33.12%,22.13% and 19.07%,respectively;the 3-year survival rates in the JAK1,JAK2,JAK3 and TYK2 mRNA negative expression groups were 46.56%,51.25%,39.55% and 37.02%,respectively.COX regression analysis showed that the positive expressions of JAK3 and TYK2 mRNA were the independent risk factors affecting the prognosis of AML patients.Conclusions: JAKs family genes play an important role in the occurrence and development of AML,especially the positive expressions of JAK3 and TYK2 mRNA are closely connected with CR and overall survival,and directly affect the prognosis.
Objective: To analyze the expressions of JAKs family-gene in different periods of acute myeloid leukemia(AML) cells,and its correlation with the prognosis of patients.Methods: The mRNA expressions of JAKs family-gene(including JAK1,JAK2,JAK3 and TYK2) in bone marrow MNC of the first-treated group,recurrence group and complete remission group(CR group) and normal control group(NC group) were detected using RT-PCR method.All cases were followed up for 3 years,and the 3-year survival rate was analyzed.Results: The expression levels of the JAK3 and TYK2 mRNA in the first-treated group and recurrence group were higher than those in CR group and NC group(P<0.05 to P<0.01),the differences of the expression level of the JAK2 mRNA in the 4 groups were were statisticallg significant(P<0.05),and the differences of the mRNA expression levels of JAKs family-gene between the first-treated group,recurrence group,CR group and NC group were not statistically significant(P>0.05).The differences of the CR rate in the JAK1,JAK2,JAK3 and TYK2 positive group and negative group were not statistically significant(P>0.05).Kaplan-Meier analysis showed that the 3-year survival rates in the JAK1,JAK2,JAK3 and TYK2 mRNA positive expression groups were 36.75%,33.12%,22.13% and 19.07%,respectively;the 3-year survival rates in the JAK1,JAK2,JAK3 and TYK2 mRNA negative expression groups were 46.56%,51.25%,39.55% and 37.02%,respectively.COX regression analysis showed that the positive expressions of JAK3 and TYK2 mRNA were the independent risk factors affecting the prognosis of AML patients.Conclusions: JAKs family genes play an important role in the occurrence and development of AML,especially the positive expressions of JAK3 and TYK2 mRNA are closely connected with CR and overall survival,and directly affect the prognosis.
2015, 40(10): 1309-1311.
Abstract:
Objective: To investigate the expression of breast cancer metastasis suppressor 1(BRMS1) and its clinical significance in gastric carcinoma.Methods: The expression of BRMS1 in gastric carcinoma tissues(n=60) and para-cancerous tissues(n=60) was detected by immunohistochemiscal method.The relationship between the immunohistochemiscal results and the clinic pathologic parameters were analyzed.Results: The expression rate of BRMS1 in gastric carcinoma tissues(35.0%)was significantly lower than that in para-cancerous tissues(75.0%)(P<0.01);there was the correlation between the expression of BRMS1 and the degree of differentiation,lymph node metastasis and clinical stages(P<0.01), there was no correlation between the expression of BRMS1 and patient sex,age,infiltrative depth and size of tumor (P>0.05).Conclusions: The BRMS1 protein was lower-expression in gastric carcinoma,which may be related with the tumor genesis,invasion and metastasis of gastric carcinoma.
Objective: To investigate the expression of breast cancer metastasis suppressor 1(BRMS1) and its clinical significance in gastric carcinoma.Methods: The expression of BRMS1 in gastric carcinoma tissues(n=60) and para-cancerous tissues(n=60) was detected by immunohistochemiscal method.The relationship between the immunohistochemiscal results and the clinic pathologic parameters were analyzed.Results: The expression rate of BRMS1 in gastric carcinoma tissues(35.0%)was significantly lower than that in para-cancerous tissues(75.0%)(P<0.01);there was the correlation between the expression of BRMS1 and the degree of differentiation,lymph node metastasis and clinical stages(P<0.01), there was no correlation between the expression of BRMS1 and patient sex,age,infiltrative depth and size of tumor (P>0.05).Conclusions: The BRMS1 protein was lower-expression in gastric carcinoma,which may be related with the tumor genesis,invasion and metastasis of gastric carcinoma.
2015, 40(10): 1312-1314,1317.
Abstract:
Objective: To establish the end-to-side anastomosis model of the common carotid artery(CCA) in rat for simulating the operation model of vascular anastomosis.Methods: The end-to-side anastomosis model of left CCA and distal end of right CCA under the trachea tissue in 20 adult SD rat was established.The number of suture needle and anastomosis time were recorded.The anastomotic vessel and brain were stained using HE and 2,3,5-triphenyl tetrazolium chloride,respectively.Results: The end-to-side anastomosis model of CCA was established in rat,the successful rate of which was 100%.The number of suture needle was 7,and anastomosis time were 40±5 min,respectively.The patency rate of anastomosis was 100% after one month of anastomosis.The HE and 2,3,5-triphenyl tetrazolium chloride staining showed that the anastomosis healing was good,and brain had no cerebral ischemia.Conclusions: The blood vessel branch and nerve around the CCA should be protected during the process of model-making,the model can be used in the study of surgical treatment of moyamoya disease and vascular transplantation.
Objective: To establish the end-to-side anastomosis model of the common carotid artery(CCA) in rat for simulating the operation model of vascular anastomosis.Methods: The end-to-side anastomosis model of left CCA and distal end of right CCA under the trachea tissue in 20 adult SD rat was established.The number of suture needle and anastomosis time were recorded.The anastomotic vessel and brain were stained using HE and 2,3,5-triphenyl tetrazolium chloride,respectively.Results: The end-to-side anastomosis model of CCA was established in rat,the successful rate of which was 100%.The number of suture needle was 7,and anastomosis time were 40±5 min,respectively.The patency rate of anastomosis was 100% after one month of anastomosis.The HE and 2,3,5-triphenyl tetrazolium chloride staining showed that the anastomosis healing was good,and brain had no cerebral ischemia.Conclusions: The blood vessel branch and nerve around the CCA should be protected during the process of model-making,the model can be used in the study of surgical treatment of moyamoya disease and vascular transplantation.
2015, 40(10): 1315-1317.
Abstract:
Objective: To study the effects of chronic intermittent hypoxia training on rat myocardial ATP content Na+,K+-ATPase and Ca2+,Mg2- ATPase activities.Methods: Thirty-two male Wistar rats were divided into chronic group,acute group and control group according to the low oxygen training program,The rats in chronic group were subjected to chronic intermittent hypoxia training,daily training at 3 km simulated altitude for 4 h for 2 weeks,then daily training under 5 km simulated altitude for,4 h for the next 2 weeks,finally placed for 4 h under 8 km simulated altitude.The rats in acute group were immediately under 8 km simulated altitude for 4 h,and the rats in control group were no hypoxic training.After the expiry of the low oxygen,the rats were executed,myocardial mitochondria were separated and ATP enzyme activities were determined.Results: In chronic group,ATP enzyme content was(9.04±4.71) μmol·mg-1·h-1,which was higher than(4.96±1.17) μmol·mg-1·h-1 in acute group and(4.38±0.95) μmol·mg-1·h-1 in control group(P<0.01).In chronic group,Na+,K+ ATPase activity was(2.55±1.41) μmol·mg-1·h-1,and(2.66±1.07) μmol·mg-1·h-1 in acute group,(3.08±1.37) μmol·mg-1·h-1 in control group,there had no statistical difference among the three groups(P>0.05).In chronic group,Ca2+,Mg2+ ATPase activity was(1.17±0.34) μmol·mg-1·h-1,and(1.28±0.42) μmol·mg-1·h-1 in control group,which had no statistical significance between the two groups(P>0.05),but was higher than(0.58±0.14) μmol·mg-1·h-1 in acute group(P<0.01).Conclusions: Chronic intermittent hypoxia training can enhance Ca2+,Mg2+ ATPase activity,at the same time can significantly increase ATPase content,which can improve myocardial motion function,the rats can adapt the hypoxic environment.
Objective: To study the effects of chronic intermittent hypoxia training on rat myocardial ATP content Na+,K+-ATPase and Ca2+,Mg2- ATPase activities.Methods: Thirty-two male Wistar rats were divided into chronic group,acute group and control group according to the low oxygen training program,The rats in chronic group were subjected to chronic intermittent hypoxia training,daily training at 3 km simulated altitude for 4 h for 2 weeks,then daily training under 5 km simulated altitude for,4 h for the next 2 weeks,finally placed for 4 h under 8 km simulated altitude.The rats in acute group were immediately under 8 km simulated altitude for 4 h,and the rats in control group were no hypoxic training.After the expiry of the low oxygen,the rats were executed,myocardial mitochondria were separated and ATP enzyme activities were determined.Results: In chronic group,ATP enzyme content was(9.04±4.71) μmol·mg-1·h-1,which was higher than(4.96±1.17) μmol·mg-1·h-1 in acute group and(4.38±0.95) μmol·mg-1·h-1 in control group(P<0.01).In chronic group,Na+,K+ ATPase activity was(2.55±1.41) μmol·mg-1·h-1,and(2.66±1.07) μmol·mg-1·h-1 in acute group,(3.08±1.37) μmol·mg-1·h-1 in control group,there had no statistical difference among the three groups(P>0.05).In chronic group,Ca2+,Mg2+ ATPase activity was(1.17±0.34) μmol·mg-1·h-1,and(1.28±0.42) μmol·mg-1·h-1 in control group,which had no statistical significance between the two groups(P>0.05),but was higher than(0.58±0.14) μmol·mg-1·h-1 in acute group(P<0.01).Conclusions: Chronic intermittent hypoxia training can enhance Ca2+,Mg2+ ATPase activity,at the same time can significantly increase ATPase content,which can improve myocardial motion function,the rats can adapt the hypoxic environment.
2015, 40(10): 1318-1320.
Abstract:
Objective: To investigate the characteristics of short-term heart rate variability(HRV) in healthy college students.Methods: The electrocardiogram data were recorded with a portable electrocardiogram recorder in 410 college students,the HRV parameters in differentn gender were analyzed by time-domain,frequency-domain and Poincaré scatterplot analysis,respectively.Results: In the time-domain parameters,the values of mean R-R intervals,standard deviation of normal-to-normal intervals,and root mean square of the successive differences of normal-to-normal intervals in females were lower than those in males(P<0.05 to P<0.01).In the frequency-domain parameters,the low frequency power(LF),high frequency power(HF),and total power in females were lower than in males(P<0.05 to P<0.01).There were no significant gender differences of these values including very low frequency power,normalized LF,normalized HF,and LF/HF ratio(P>0.05).In the Poincaré plot parameters,the values of width and length were lower in females than in males(P<0.05).Conclusions: In healthy college students,gender exerts the significant effects on HRV time-domain parameters,some frequency-domain parameters and Poincaré scatterplot parameters.The results can provide a statistical reference for further basic and clinical application research.
Objective: To investigate the characteristics of short-term heart rate variability(HRV) in healthy college students.Methods: The electrocardiogram data were recorded with a portable electrocardiogram recorder in 410 college students,the HRV parameters in differentn gender were analyzed by time-domain,frequency-domain and Poincaré scatterplot analysis,respectively.Results: In the time-domain parameters,the values of mean R-R intervals,standard deviation of normal-to-normal intervals,and root mean square of the successive differences of normal-to-normal intervals in females were lower than those in males(P<0.05 to P<0.01).In the frequency-domain parameters,the low frequency power(LF),high frequency power(HF),and total power in females were lower than in males(P<0.05 to P<0.01).There were no significant gender differences of these values including very low frequency power,normalized LF,normalized HF,and LF/HF ratio(P>0.05).In the Poincaré plot parameters,the values of width and length were lower in females than in males(P<0.05).Conclusions: In healthy college students,gender exerts the significant effects on HRV time-domain parameters,some frequency-domain parameters and Poincaré scatterplot parameters.The results can provide a statistical reference for further basic and clinical application research.
2015, 40(10): 1320-1322.
Abstract:
Objective: To understand the prevalence of the mammary gland disease in Longzihu district of Bengbu,analyze its risk factors for exploring the reasonable and scientific prevention measure.Methods: The health prevention knowledge about breast was propagated in Longzihu district women of Bengbu.The epidemiologic investigation was executed in 1 288 voluntary women,the results of which combined with mammography and pathology examination were summarized and analyzed.Results: Eight thousand and thirty-four breast disease patients were found,the morbidity of which was 64.75%.The patients included breast hyperplasia in 676 cases,benign breast tumor in 144 cases,breast cancer in 3 cases and other breast diseases in 11 cases.The prevalence rates of breast disease in 31 to 40 years old and 41 to 50 years old women were higher than that in 21 to 30 years old and more 51 years old women(P<0.05).Conclusions: The morbidity of female breast disease in Longzihu district of Bengbu is high.The regular breast test and taking effective measures to strengthen the secondary prevention of breast disease should be implemented.
Objective: To understand the prevalence of the mammary gland disease in Longzihu district of Bengbu,analyze its risk factors for exploring the reasonable and scientific prevention measure.Methods: The health prevention knowledge about breast was propagated in Longzihu district women of Bengbu.The epidemiologic investigation was executed in 1 288 voluntary women,the results of which combined with mammography and pathology examination were summarized and analyzed.Results: Eight thousand and thirty-four breast disease patients were found,the morbidity of which was 64.75%.The patients included breast hyperplasia in 676 cases,benign breast tumor in 144 cases,breast cancer in 3 cases and other breast diseases in 11 cases.The prevalence rates of breast disease in 31 to 40 years old and 41 to 50 years old women were higher than that in 21 to 30 years old and more 51 years old women(P<0.05).Conclusions: The morbidity of female breast disease in Longzihu district of Bengbu is high.The regular breast test and taking effective measures to strengthen the secondary prevention of breast disease should be implemented.
2015, 40(10): 1323-1325.
Abstract:
Objective: To explore the application value of the fast tracksurgery(FTS) concept in the anesthesia of esophageal cancer operation.Methods: Sixty esophageal cancer patients scheduled by operation were randomly divided into the fast tracksurgery treatment group(observation group,30 cases),who were treated with combined general-epidural anesthesia surgery,the restrictive transfusion management,warming blanket insulation in operation and epidural analgesia pump after operation,and regular operation group(control group,30 cases),who were treated with the general anesthesia surgery and conventional intravenous analgesia pump after operation.The serum cortisol and blood glucose levels between two groups were detected and compared before anesthesia,and at the time of cutting the skin,taking out the specimen and the end of surgery.The extubation time,anal exhaust time,hospitalization time and incidence of postoperative complications in two groups were observed.Results: The blood glucose and serum cortisol levels in control group at the time of cutting the skin,taking out the specimen and the end of surgery were significantly higher than those of before anesthesia(P<0.01),and each time-point of the observation group(P<0.01).Compared with these of before anesthesia in observation group,the changes of the blood glucose levels at the time of cutting the skin,taking out the specimen and the end of surgery were no obvious(P>0.05),and the serum cortisol levels significantly increased(P<0.01).The postoperative extubation time,anal exhaust time and hospitalization time in observation group were less than those in control group(P<0.05 to P<0.01),the difference of the incidence of complication between two groups was not statistically significant(P>0.05).Conclusions: The application of the fast tracksurgery concept in the anesthesia of esophageal cancer operation can promote the recovery of patients.
Objective: To explore the application value of the fast tracksurgery(FTS) concept in the anesthesia of esophageal cancer operation.Methods: Sixty esophageal cancer patients scheduled by operation were randomly divided into the fast tracksurgery treatment group(observation group,30 cases),who were treated with combined general-epidural anesthesia surgery,the restrictive transfusion management,warming blanket insulation in operation and epidural analgesia pump after operation,and regular operation group(control group,30 cases),who were treated with the general anesthesia surgery and conventional intravenous analgesia pump after operation.The serum cortisol and blood glucose levels between two groups were detected and compared before anesthesia,and at the time of cutting the skin,taking out the specimen and the end of surgery.The extubation time,anal exhaust time,hospitalization time and incidence of postoperative complications in two groups were observed.Results: The blood glucose and serum cortisol levels in control group at the time of cutting the skin,taking out the specimen and the end of surgery were significantly higher than those of before anesthesia(P<0.01),and each time-point of the observation group(P<0.01).Compared with these of before anesthesia in observation group,the changes of the blood glucose levels at the time of cutting the skin,taking out the specimen and the end of surgery were no obvious(P>0.05),and the serum cortisol levels significantly increased(P<0.01).The postoperative extubation time,anal exhaust time and hospitalization time in observation group were less than those in control group(P<0.05 to P<0.01),the difference of the incidence of complication between two groups was not statistically significant(P>0.05).Conclusions: The application of the fast tracksurgery concept in the anesthesia of esophageal cancer operation can promote the recovery of patients.
2015, 40(10): 1326-1327.
Abstract:
Objective: To investigate the therapeutic effects of preserving intercostobrachial nerve(ICBN) and anterior thoracic nerve(ATN) in early mastectomy.Methods: The clinical data of 120 early breast cancer female patients treated with modified radical mastectomy were retrospectively analyzed from May 2008 to May 2011.The ICBN and ATN in 65 cases were intactly preserved(preserving group),the ICBN and ATN in 55 cases were resected(resection group).The ectopectoralis atrophy,medial feeling of upper arm,tumor local recurrence and distant metastasis between two groups were compared after operation.Results: The medial abnormal feeling of upper arm and ectopectoralis atrophy in preserving group were significantly lower than those in resection group(P<0.01).The tumor local recurrence and distant metastasis in two groups were not found during the 6 to 36 months of follow-up.Conclusions: Preserving the ICBN and ATN in modified radical mastectomy can effectively reduce the ectopectoralis atrophy and complications of upper arm,and which does not increase the risks of recurrence and metastasis of tumor.
Objective: To investigate the therapeutic effects of preserving intercostobrachial nerve(ICBN) and anterior thoracic nerve(ATN) in early mastectomy.Methods: The clinical data of 120 early breast cancer female patients treated with modified radical mastectomy were retrospectively analyzed from May 2008 to May 2011.The ICBN and ATN in 65 cases were intactly preserved(preserving group),the ICBN and ATN in 55 cases were resected(resection group).The ectopectoralis atrophy,medial feeling of upper arm,tumor local recurrence and distant metastasis between two groups were compared after operation.Results: The medial abnormal feeling of upper arm and ectopectoralis atrophy in preserving group were significantly lower than those in resection group(P<0.01).The tumor local recurrence and distant metastasis in two groups were not found during the 6 to 36 months of follow-up.Conclusions: Preserving the ICBN and ATN in modified radical mastectomy can effectively reduce the ectopectoralis atrophy and complications of upper arm,and which does not increase the risks of recurrence and metastasis of tumor.
2015, 40(10): 1328-1329,1332.
Abstract:
Objective: To compare the effects of exposure the recurrent laryngeal nerve between inferior thyroid artery and inferior horn of thyroid cartilage exposure approach.Methods: One hundred and twenty patients treated with the thyroid operation were divided into the inferior thyroid artery explore group(65 cases,99 items) and inferior horn of thyroid cartilage exposure group(55 cases,57 items) according to the different approaches of exposure recurrent laryngeal nerve.The time of looking for recurrent laryngeal nerve(from starting to look for recurrent laryngeal nerve to find it),peroperative bleeding(during the looking for preiod) and incidence of postoperation hoarseness between two groups were compared.Results: The differences of the time of looking for recurrent laryngeal nerve,peroperative bleeding and incidence of postoperation hoarseness between two groups were not statistical significance(P>0.05).Conclusions: Both two approaches are simple and effective means in looking and protecting the recurrent laryngeal nerve.The application of exposure approach should be based on the actual situation.
Objective: To compare the effects of exposure the recurrent laryngeal nerve between inferior thyroid artery and inferior horn of thyroid cartilage exposure approach.Methods: One hundred and twenty patients treated with the thyroid operation were divided into the inferior thyroid artery explore group(65 cases,99 items) and inferior horn of thyroid cartilage exposure group(55 cases,57 items) according to the different approaches of exposure recurrent laryngeal nerve.The time of looking for recurrent laryngeal nerve(from starting to look for recurrent laryngeal nerve to find it),peroperative bleeding(during the looking for preiod) and incidence of postoperation hoarseness between two groups were compared.Results: The differences of the time of looking for recurrent laryngeal nerve,peroperative bleeding and incidence of postoperation hoarseness between two groups were not statistical significance(P>0.05).Conclusions: Both two approaches are simple and effective means in looking and protecting the recurrent laryngeal nerve.The application of exposure approach should be based on the actual situation.
2015, 40(10): 1330-1332.
Abstract:
Objective: To evaluate the short-term effects of paclitaxel combined with nedaplatin in the chemotherapy of locally advanced cervical cancer.Methods: Among 60 patients with locally advanced cervical cancer diagnosed by pathology,30 cases(chemotherapy group) were treated with intravenous chemotherapy of paclitaxel combined with Cisplatin for 1 to 2 courses,then with radical hysterectomy of cervical cancer,other 30 cases were treated with direct surgical treatment(control group).Results: The operation time,blood loss and recovery time of gastrointestinal function in chemotherapy group were less than those in control group(P<0.01),the rate of lymph node metastasis in chemotherapy group was lower than that in control group(P<0.05).Conclusions: The preoperative chemotherapy of paclitaxel combined with nedaplatin in the treatment of locally advanced cervical cancer is good effects,which can significantly shrink the cervical masses,shorten operating time,and reduce blood loss,lymph node metastasis and postoperative complications.
Objective: To evaluate the short-term effects of paclitaxel combined with nedaplatin in the chemotherapy of locally advanced cervical cancer.Methods: Among 60 patients with locally advanced cervical cancer diagnosed by pathology,30 cases(chemotherapy group) were treated with intravenous chemotherapy of paclitaxel combined with Cisplatin for 1 to 2 courses,then with radical hysterectomy of cervical cancer,other 30 cases were treated with direct surgical treatment(control group).Results: The operation time,blood loss and recovery time of gastrointestinal function in chemotherapy group were less than those in control group(P<0.01),the rate of lymph node metastasis in chemotherapy group was lower than that in control group(P<0.05).Conclusions: The preoperative chemotherapy of paclitaxel combined with nedaplatin in the treatment of locally advanced cervical cancer is good effects,which can significantly shrink the cervical masses,shorten operating time,and reduce blood loss,lymph node metastasis and postoperative complications.
2015, 40(10): 1333-1335.
Abstract:
Objective: To explore the changes of T cell subsets in Mycoplasma pneumonia(MPP) children with different chest X-ray manifestations.Methods: One hundred and fifty-six children with MPP were divided into group A and group B according to the lobar pneumonia change.The chest X-ray in group A and group B showed the lobar pneumonia change and non-lobar pneumonia change,respectively.Sixty-two healthy children were set as the control group(group C).The T cell subsets in 3 groups were detected and analyzed.Results: Compared with group C,the levels of CD4+ and CD4+/CD8+ in group A were significantly lower,while the level of CD8+ in group A was significantly higher(P<0.01).Conclusions: Immune injury plays an important role in the pathogenesis of MPP.The chest X-ray in older MPP children shows lobar pneumonia,which is strongly immunodepressed.
Objective: To explore the changes of T cell subsets in Mycoplasma pneumonia(MPP) children with different chest X-ray manifestations.Methods: One hundred and fifty-six children with MPP were divided into group A and group B according to the lobar pneumonia change.The chest X-ray in group A and group B showed the lobar pneumonia change and non-lobar pneumonia change,respectively.Sixty-two healthy children were set as the control group(group C).The T cell subsets in 3 groups were detected and analyzed.Results: Compared with group C,the levels of CD4+ and CD4+/CD8+ in group A were significantly lower,while the level of CD8+ in group A was significantly higher(P<0.01).Conclusions: Immune injury plays an important role in the pathogenesis of MPP.The chest X-ray in older MPP children shows lobar pneumonia,which is strongly immunodepressed.
2015, 40(10): 1335-1337.
Abstract:
Objective: To explore the clinical effects of the corneal limbal stem cells autotransplantation in the treatment of pterygium.Methods: Eighty-four cases(98 eyes) were randomly divided into the group A and group B(42 cases each group).Group A(50 eyes) were treated with conventional peteryguim excision,group B(48 eyes) were treated with the pterygium excision combined with corneal limbal stem cells autotransplantation,respectively.The recurrence rate,healing rate,healing time of corneal epithelial wound and postoperative reactions between two groups were compared.Results: The recurrence rate in group B(4.2%) was lower than that in group A(20.0%)(P<0.05).The healing time of corneal epithelial wound in group B[(4.1±1.9)d] was less than that in group A[(6.9±2.3)d](P<0.01).The obviously postoperative discomfort in 2 cases of group B(4.2%) was less than that in 13 cases of group A(26.0%)(P<0.01).Conclusions: The treatment of pterygium with conventional pterygium excision combined with corneal limbal stem cells autotransplantation can effectively reduce the recurrence rate,increase the healing rate,improve the corneal epithelial wound healing and reduce the postoperative reaction,which is worthy of clinical promotion and application.
Objective: To explore the clinical effects of the corneal limbal stem cells autotransplantation in the treatment of pterygium.Methods: Eighty-four cases(98 eyes) were randomly divided into the group A and group B(42 cases each group).Group A(50 eyes) were treated with conventional peteryguim excision,group B(48 eyes) were treated with the pterygium excision combined with corneal limbal stem cells autotransplantation,respectively.The recurrence rate,healing rate,healing time of corneal epithelial wound and postoperative reactions between two groups were compared.Results: The recurrence rate in group B(4.2%) was lower than that in group A(20.0%)(P<0.05).The healing time of corneal epithelial wound in group B[(4.1±1.9)d] was less than that in group A[(6.9±2.3)d](P<0.01).The obviously postoperative discomfort in 2 cases of group B(4.2%) was less than that in 13 cases of group A(26.0%)(P<0.01).Conclusions: The treatment of pterygium with conventional pterygium excision combined with corneal limbal stem cells autotransplantation can effectively reduce the recurrence rate,increase the healing rate,improve the corneal epithelial wound healing and reduce the postoperative reaction,which is worthy of clinical promotion and application.
2015, 40(10): 1338-1340.
Abstract:
Objective: To analyze the polymorphism of ALOX5AP and PDE4D gene and molecular epidemiology of the susceptibility of cerebral infarction(CI).Methods: Three hundred and ninty-six patients with CI and 300 healthy people were divided into the CI group and control group.The polymorphism of SG13S89 and SG13S114 in ALOX5AP gene,and SNP83 in PDE4D gene in two groups were detected using PCR and matrix assisted laser desorption,and the relationship between the polymorphism of ALOX5AP and PDE4D gene and CI were analyzed.Results: The AG gene type and allele A frequency in SG13S89 in CI group were higher than those in control group(P< 0.05).Logistic regression analysis showed that the AG gene type in SG13S89 was the risk factor in increasing the CI after adjusting the influence factors of age,hypertension and diabetes mellitus(P< 0.05).The differences of the gene type and frequency of AT and SAD in SG13S89 gene of cerebral infarction patients were not statistically significant(P>0.05).The age stratification analysis found that female was the risk factor of the CI in increasing AG gene type of SG13S89 of patients(P< 0.05).Conclusions: The frequency of CI in the patients with AG type and A allele in SG13S89 is higher than other alleles,the possible mechanism of which is implemented through mediating vascular inflammatory reaction,and the relationship between the polymorphism of SG13S114 and SNP83 gene and CI is not found.
Objective: To analyze the polymorphism of ALOX5AP and PDE4D gene and molecular epidemiology of the susceptibility of cerebral infarction(CI).Methods: Three hundred and ninty-six patients with CI and 300 healthy people were divided into the CI group and control group.The polymorphism of SG13S89 and SG13S114 in ALOX5AP gene,and SNP83 in PDE4D gene in two groups were detected using PCR and matrix assisted laser desorption,and the relationship between the polymorphism of ALOX5AP and PDE4D gene and CI were analyzed.Results: The AG gene type and allele A frequency in SG13S89 in CI group were higher than those in control group(P< 0.05).Logistic regression analysis showed that the AG gene type in SG13S89 was the risk factor in increasing the CI after adjusting the influence factors of age,hypertension and diabetes mellitus(P< 0.05).The differences of the gene type and frequency of AT and SAD in SG13S89 gene of cerebral infarction patients were not statistically significant(P>0.05).The age stratification analysis found that female was the risk factor of the CI in increasing AG gene type of SG13S89 of patients(P< 0.05).Conclusions: The frequency of CI in the patients with AG type and A allele in SG13S89 is higher than other alleles,the possible mechanism of which is implemented through mediating vascular inflammatory reaction,and the relationship between the polymorphism of SG13S114 and SNP83 gene and CI is not found.
2015, 40(10): 1341-1343.
Abstract:
Objective: To analyze the effects of different nutrition modes on the glycemic control and gastrointestinal dysfunction in sepsis patients without gastrointestinal dysfunction.Methods: One hundred and thirty-eight sepsis patients were randomly divided into the enteral nutrition group and meal served nutrition group(69 cases each group).The enteral nutrition group and meal served nutrition group were treated with enteral nutrition liquid infusion and nutrition liquid meal served,respectively.The blood glucose control and incidence of gastrointestinal dysfunction between two groups were compared.Results: The incidence rates of hyperglycemia in enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 4.3% and 13.0%,respectively,the difference of which was not statistically significant(P>0.05).The difference of fasting blood glucose between two groups before nutritional support was not statistically significant(P>0.05).Compared with before the nutritional support,the blood glucose levels in two groups after 1 to 15 d of nutritional support increased significantly(P<0.01),the fasting blood glucose level in the enteral nutrient solution group after 1 to 15 d of nutritional support were lower than that in the meal served nutrition group(P<0.01).The incidences of gastrointestinal dysfunction in the enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 5.8% and 15.9%,respectively,the difference of which was not statistically significant(P>0.05).Compared before nutrition support,the GIDF and SOFA scores in two groups after 15 d of nutrition support increased significantly(P<0.01).The GIDF and SOFA scores in the enteral nutrient solution group after 15 d of nutrition support were significantly lower than those in the meal served nutrition group(P<0.01).Pearson correlation analysis indicated that the GIDF score was positive correlation with SOFA score(P<0.01).Conclusions: The incidences of the hyperglycaemia and gastrointestinal dysfunction between two groups are similar.The continuing enteral nutrient solution has better effects on the energy supply and improving the prognosis of patients,which is the preferred way in nutritional support for patients with sepsis.
Objective: To analyze the effects of different nutrition modes on the glycemic control and gastrointestinal dysfunction in sepsis patients without gastrointestinal dysfunction.Methods: One hundred and thirty-eight sepsis patients were randomly divided into the enteral nutrition group and meal served nutrition group(69 cases each group).The enteral nutrition group and meal served nutrition group were treated with enteral nutrition liquid infusion and nutrition liquid meal served,respectively.The blood glucose control and incidence of gastrointestinal dysfunction between two groups were compared.Results: The incidence rates of hyperglycemia in enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 4.3% and 13.0%,respectively,the difference of which was not statistically significant(P>0.05).The difference of fasting blood glucose between two groups before nutritional support was not statistically significant(P>0.05).Compared with before the nutritional support,the blood glucose levels in two groups after 1 to 15 d of nutritional support increased significantly(P<0.01),the fasting blood glucose level in the enteral nutrient solution group after 1 to 15 d of nutritional support were lower than that in the meal served nutrition group(P<0.01).The incidences of gastrointestinal dysfunction in the enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 5.8% and 15.9%,respectively,the difference of which was not statistically significant(P>0.05).Compared before nutrition support,the GIDF and SOFA scores in two groups after 15 d of nutrition support increased significantly(P<0.01).The GIDF and SOFA scores in the enteral nutrient solution group after 15 d of nutrition support were significantly lower than those in the meal served nutrition group(P<0.01).Pearson correlation analysis indicated that the GIDF score was positive correlation with SOFA score(P<0.01).Conclusions: The incidences of the hyperglycaemia and gastrointestinal dysfunction between two groups are similar.The continuing enteral nutrient solution has better effects on the energy supply and improving the prognosis of patients,which is the preferred way in nutritional support for patients with sepsis.
2015, 40(10): 1344-1345.
Abstract:
Objective: To investigate the value of serum creatinine(Scr),blood urea nitrogen(BUN) and serum uric acid(UA) in the evaluation of the renal injury of gestational diabetes mellitus(GDM) patients.Methods: Ninty-nine labor and delivery patients with GDM and 99 normal pregnancy women were divided into the GDM group and control group,respectively.The levels of Scr,BUN and serum UA between two groups were compared.Results: The UA level in the GDM group was significantly higher than that in the control group(P<0.01).The differences of the levels of BUN and Ser between two groups were not statistically significant(P>0.05).The incidence of UA abnormality in GDM group was significantly higher than that in the control group(P<0.01).Conclusions: The abnormal increase of serum UA level may be a sensitive indicator of early damage of renal function in GDM.
Objective: To investigate the value of serum creatinine(Scr),blood urea nitrogen(BUN) and serum uric acid(UA) in the evaluation of the renal injury of gestational diabetes mellitus(GDM) patients.Methods: Ninty-nine labor and delivery patients with GDM and 99 normal pregnancy women were divided into the GDM group and control group,respectively.The levels of Scr,BUN and serum UA between two groups were compared.Results: The UA level in the GDM group was significantly higher than that in the control group(P<0.01).The differences of the levels of BUN and Ser between two groups were not statistically significant(P>0.05).The incidence of UA abnormality in GDM group was significantly higher than that in the control group(P<0.01).Conclusions: The abnormal increase of serum UA level may be a sensitive indicator of early damage of renal function in GDM.
2015, 40(10): 1346-1349.
Abstract:
Objective: To evaluate the effects and adverse reactions of the tegafur combined with body gamma knife in the treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis.Methods: The clinical data of 69 esophageal neoplasm patients with retroperitoneal lymph node metastases were retrospectively analyzed.Fixing vacuum pad and three-dimensional stereotactic body,enhancing CT scan,enlarging the tumor target area for 10 mm as planning target area,50% dose line embracing 95% planning target area as prescription dose curve and 350 to 450 cGy one time(5 times a week) were implemented at the time of body gamma knife therapy.The treatment was consist of 10 to 12 times,and the total dose of the tumor margin was 4 200-4 950 cGy.Among 69 cases,36 patients(combination group) were treated with the body gamma knife combined with tegafur(40 mg/m2,2 times 1 d,28 days 1 cycle for 4 cycles),33 patients(control group) were only treated with the body gamma knife therapy.Results: The short-term effective rate and 1-year survival rate in the combination group and control group were 86.11% & 77.78% and 63.63% & 54.54%,respectively.The 1-year survival rate in the combination group was higher than that in the control group(P<0.05).The total effective rate of pain relief in the combination group and control group were 91.18% and 77.42%,respectively,the difference of which was not statistically significant(P>0.05).The difference of the acute adverse reaction between two groups was not statistically significant(P>0.05).The patients could tolerate,and were improved after positive treatment.No case died.Conclusions: The treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis with tegafur combined with body gamma knife treatment can improve 1-year survival rate,and does not increase the adverse reaction of patients.
Objective: To evaluate the effects and adverse reactions of the tegafur combined with body gamma knife in the treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis.Methods: The clinical data of 69 esophageal neoplasm patients with retroperitoneal lymph node metastases were retrospectively analyzed.Fixing vacuum pad and three-dimensional stereotactic body,enhancing CT scan,enlarging the tumor target area for 10 mm as planning target area,50% dose line embracing 95% planning target area as prescription dose curve and 350 to 450 cGy one time(5 times a week) were implemented at the time of body gamma knife therapy.The treatment was consist of 10 to 12 times,and the total dose of the tumor margin was 4 200-4 950 cGy.Among 69 cases,36 patients(combination group) were treated with the body gamma knife combined with tegafur(40 mg/m2,2 times 1 d,28 days 1 cycle for 4 cycles),33 patients(control group) were only treated with the body gamma knife therapy.Results: The short-term effective rate and 1-year survival rate in the combination group and control group were 86.11% & 77.78% and 63.63% & 54.54%,respectively.The 1-year survival rate in the combination group was higher than that in the control group(P<0.05).The total effective rate of pain relief in the combination group and control group were 91.18% and 77.42%,respectively,the difference of which was not statistically significant(P>0.05).The difference of the acute adverse reaction between two groups was not statistically significant(P>0.05).The patients could tolerate,and were improved after positive treatment.No case died.Conclusions: The treatment of patients with esophageal neoplasm complicated with retroperitoneal lymph node metastasis with tegafur combined with body gamma knife treatment can improve 1-year survival rate,and does not increase the adverse reaction of patients.
2015, 40(10): 1349-1351.
Abstract:
Objective: To explore the effects of sodium hyaluronate combined with solifenacin on cystitis caused by chemical drugs.Methods: Forty-four patients with chemical cystitis caused by chemical drugs after operation of bladder cancer were divided into the control group and treatment group which were treated with solifenacin and sodium hyaluronate combined with solifenacin,respectively.The clinical efficacy and safety in all patients were evaluated in 4 weeks after treatment.Results: Compared with before treatment,the mean number of micturition,urgency episode,urge incontinence and vesical pain per day in two groups were significantly improved after treatment(P<0.01),the improvement in the number of micturition and vesical pain of the treatment group were better than that of the control group(P<0.01),the differences of the number of urgency episode and urge incontinence between two groups were not statistically significant(P>0.05).The mean urine output in treatment group improved significantly after treatment(P<0.01),but it was not statistically significant in control group(P>0.05).Conclusions: The treatment of sodium hyaluronate combined with solifenacin can obviously alleviate the bladder irritative symptom,increase bladder capacity,alleviate the suffering of the patients with chemical cystitis,the effect of which is better than that of solifenacin.
Objective: To explore the effects of sodium hyaluronate combined with solifenacin on cystitis caused by chemical drugs.Methods: Forty-four patients with chemical cystitis caused by chemical drugs after operation of bladder cancer were divided into the control group and treatment group which were treated with solifenacin and sodium hyaluronate combined with solifenacin,respectively.The clinical efficacy and safety in all patients were evaluated in 4 weeks after treatment.Results: Compared with before treatment,the mean number of micturition,urgency episode,urge incontinence and vesical pain per day in two groups were significantly improved after treatment(P<0.01),the improvement in the number of micturition and vesical pain of the treatment group were better than that of the control group(P<0.01),the differences of the number of urgency episode and urge incontinence between two groups were not statistically significant(P>0.05).The mean urine output in treatment group improved significantly after treatment(P<0.01),but it was not statistically significant in control group(P>0.05).Conclusions: The treatment of sodium hyaluronate combined with solifenacin can obviously alleviate the bladder irritative symptom,increase bladder capacity,alleviate the suffering of the patients with chemical cystitis,the effect of which is better than that of solifenacin.
2015, 40(10): 1352-1353,1356.
Abstract:
Objective: To explore the effects of different ligation methods on the plaque index(PLI) and sulcus bleeding index(SBI) of patients with orthodontic treatment.Methods: Ninety patients with orthodontic treatment were randomly divided into the rubber band ligation group(group Ⅰ) and ligature group(group Ⅱ) and AO self-ligating group(group Ⅲ) according to the different ligation methods.The PLI and SBI in three groups were measured at 6 months before and after treatment.Results: The differences of PLI and SBI between group Ⅰ,group Ⅱ and group Ⅲ before treatment were not statistically significant(P>0.05).Compared with these before treatment,the PLI and SBI in 3 groups after 3 months of treatment significantly increased(P<0.01).The PLI and SBI in group Ⅰ after 6 months of treatment were significantly higher than these in group Ⅱ and group Ⅲ(P<0.01).After 6 months of treatment,the PLI in group Ⅱ was significantly higher than that in group Ⅲ(P<0.01),and the difference of SBI between group Ⅱ and group Ⅲ was not statistically significant(P>0.05).Conclusions: The effects of the self-ligating and ligature on preventing dental plaque and gingivitis are better than these of rubber band ligation,and which can be applied in orthodontic treatment.
Objective: To explore the effects of different ligation methods on the plaque index(PLI) and sulcus bleeding index(SBI) of patients with orthodontic treatment.Methods: Ninety patients with orthodontic treatment were randomly divided into the rubber band ligation group(group Ⅰ) and ligature group(group Ⅱ) and AO self-ligating group(group Ⅲ) according to the different ligation methods.The PLI and SBI in three groups were measured at 6 months before and after treatment.Results: The differences of PLI and SBI between group Ⅰ,group Ⅱ and group Ⅲ before treatment were not statistically significant(P>0.05).Compared with these before treatment,the PLI and SBI in 3 groups after 3 months of treatment significantly increased(P<0.01).The PLI and SBI in group Ⅰ after 6 months of treatment were significantly higher than these in group Ⅱ and group Ⅲ(P<0.01).After 6 months of treatment,the PLI in group Ⅱ was significantly higher than that in group Ⅲ(P<0.01),and the difference of SBI between group Ⅱ and group Ⅲ was not statistically significant(P>0.05).Conclusions: The effects of the self-ligating and ligature on preventing dental plaque and gingivitis are better than these of rubber band ligation,and which can be applied in orthodontic treatment.
2015, 40(10): 1354-1356.
Abstract:
Objective: To discuss the effects of nicorandil on the cardiac functions of patients with ischemic cardiomyopathy.Methods: Seventy-two ischemic cardiomyopathy patients treated without vascular remodeling were randomly divided into the observation group and control group(36 cases each group).All patients were treated with aspirin,diuretic,digitalis,angiotensin converting enzyme inhibitor,clopidogrel,aldosterone antagonist,nitrate and beta blocker.The observation group were additionally treated with nicorandil.The level of BNP,6 minutes walking distance and echocardiography between two groups before treatment and after 6 months of treatment were analyzed.The major adverse cardiac events of all patients were recorded during the hospitalization and after 6 months of discharge.Results: The effective rate in observation group(97.2%) was significantly higher than that in control group(80.6%)(P<0.05).The improvement of left ventricular end-diastolic volume,left ventricular end-systolic volume,early diastolic mitral inflow velocity/late diastolic mitral inflow velocity in observation group were better than those in control group(P<0.05 to P<0.01).The difference of the improvement of left ventricular ejection fraction between two groups was not statistically significant(P>0.05).The major adverse cardiac events of all patients were recorded during the hospitalization and after 6 months of discharge.Compared with before treatment,the 6 minutes walking distance and BNP in two groups were improved after treatment(P<0.01),especially in the observation group(P<0.01).After following-up for 6 months,the incidence of cardiac adverse event in observation group(5.56%) was lower than that in control group(22.22%) (P<0.05).Conclusions: The nicorandil can improve the cardiac functions of patients with ischemic cardiomyopathy,which is worthy of clinical application.
Objective: To discuss the effects of nicorandil on the cardiac functions of patients with ischemic cardiomyopathy.Methods: Seventy-two ischemic cardiomyopathy patients treated without vascular remodeling were randomly divided into the observation group and control group(36 cases each group).All patients were treated with aspirin,diuretic,digitalis,angiotensin converting enzyme inhibitor,clopidogrel,aldosterone antagonist,nitrate and beta blocker.The observation group were additionally treated with nicorandil.The level of BNP,6 minutes walking distance and echocardiography between two groups before treatment and after 6 months of treatment were analyzed.The major adverse cardiac events of all patients were recorded during the hospitalization and after 6 months of discharge.Results: The effective rate in observation group(97.2%) was significantly higher than that in control group(80.6%)(P<0.05).The improvement of left ventricular end-diastolic volume,left ventricular end-systolic volume,early diastolic mitral inflow velocity/late diastolic mitral inflow velocity in observation group were better than those in control group(P<0.05 to P<0.01).The difference of the improvement of left ventricular ejection fraction between two groups was not statistically significant(P>0.05).The major adverse cardiac events of all patients were recorded during the hospitalization and after 6 months of discharge.Compared with before treatment,the 6 minutes walking distance and BNP in two groups were improved after treatment(P<0.01),especially in the observation group(P<0.01).After following-up for 6 months,the incidence of cardiac adverse event in observation group(5.56%) was lower than that in control group(22.22%) (P<0.05).Conclusions: The nicorandil can improve the cardiac functions of patients with ischemic cardiomyopathy,which is worthy of clinical application.
2015, 40(10): 1357-1359,1363.
Abstract:
Objective: To investigate the serum level of adiponectin,and its correlation with insulin resistance in pregnant women with different glucose tolerance.Methods: Ninety pregnant women were divided into the normal pregnant women(NGT group),impaired glucose tolerance(GIGT group) and gestational diabetes mellitus(GDM group) according to the results of 50 g glucose load test and glucose tolerance test from January 2012 to March 2014(30 cases each group).The levels of fasting blood glucose(FPG),insulin(INS) and APN in all cases were detected by glucose oxidase method,radioimmunoassay and enzyme linked immunosorbent assay,respectively.The differences and correlations of each index in three groups were analyzed.Results: The age,gestational weeks and pre-pregnancy body mass index(BMI) were not statistically different(P>0.05),BMI of pregnant late term in 3 groups were statistically different(P<0.01).In the NGT,GIGT and GDM groups,the levels of FPG and FINS,and HOMA-IR were gradually increased,the concentration of APN was gradually decreased(P<0.01).With age and pregnant weeks as control variable,the partial correlation analysis showed that the serum APN level was significantly negative related to the BMI of pregnant late term,levels of FPG,FINS and HOMA-IR(P<0.05 to P<0.01).With APN as dependent variable,the multiple regression showed that the age,serum levels of FPG and FINS were the influencing factors in the serum level change of APN(P<0.05 to P<0.01).Conclusions: The serum APN level in pregnant women with GDM is significantly low,and a negative relationship between APN and HOMA-IR,which suggest that APN is one of the protection factors of GDM,and also is a sensitizer of INS.
Objective: To investigate the serum level of adiponectin,and its correlation with insulin resistance in pregnant women with different glucose tolerance.Methods: Ninety pregnant women were divided into the normal pregnant women(NGT group),impaired glucose tolerance(GIGT group) and gestational diabetes mellitus(GDM group) according to the results of 50 g glucose load test and glucose tolerance test from January 2012 to March 2014(30 cases each group).The levels of fasting blood glucose(FPG),insulin(INS) and APN in all cases were detected by glucose oxidase method,radioimmunoassay and enzyme linked immunosorbent assay,respectively.The differences and correlations of each index in three groups were analyzed.Results: The age,gestational weeks and pre-pregnancy body mass index(BMI) were not statistically different(P>0.05),BMI of pregnant late term in 3 groups were statistically different(P<0.01).In the NGT,GIGT and GDM groups,the levels of FPG and FINS,and HOMA-IR were gradually increased,the concentration of APN was gradually decreased(P<0.01).With age and pregnant weeks as control variable,the partial correlation analysis showed that the serum APN level was significantly negative related to the BMI of pregnant late term,levels of FPG,FINS and HOMA-IR(P<0.05 to P<0.01).With APN as dependent variable,the multiple regression showed that the age,serum levels of FPG and FINS were the influencing factors in the serum level change of APN(P<0.05 to P<0.01).Conclusions: The serum APN level in pregnant women with GDM is significantly low,and a negative relationship between APN and HOMA-IR,which suggest that APN is one of the protection factors of GDM,and also is a sensitizer of INS.
2015, 40(10): 1360-1363.
Abstract:
Objective: To investigate the curative effects of trimetazidine in the treatment of acute ischemic vascular dementia.Methods: Ninety-eight patients with acute ischemic vascular dementia were randomly divided into the treatment group and control group.The control group were treated with aspirin enteric-coated tablets,simvastatin,xuesaitong combined with oxiracetam for 3 weeks,the treatment group were additionally treated with 20 mg of trimetazidine by oral,3 times a day,based on the control group.The scores of MMSE,CDR and ADL before treatment and after 1,2 and 3 weeks of treatment and levels of TCH,TG and HCY before and after treatment in two groups were measured.Results: In treatment group,the MMSE score,and CDR and ADL scores increased and decreased gradually after 1,2 and 3 weeks of treatment,respectively.The differences of the all scores between before treatment and after 2 weeks of treatment in treatment group were statistically significant(P<0.01).After 3 weeks of treatment,the total effective rate in treatment group(83.7%) was higher than that in control group(20.4%)(P<0.01).Compared with before treatment,the levels of TCH,TG and HCY in treatment group and levels of TG and HCY in control group were significantly low after treatment(P<0.01).Conclusions: Trimetazidine can reduce the levels of TCH,TG and HCY.Trimetazidine can reduce and treat the ischemic vascular dementia,the treatment effect of which is significant after 2 weeks of treatment.
Objective: To investigate the curative effects of trimetazidine in the treatment of acute ischemic vascular dementia.Methods: Ninety-eight patients with acute ischemic vascular dementia were randomly divided into the treatment group and control group.The control group were treated with aspirin enteric-coated tablets,simvastatin,xuesaitong combined with oxiracetam for 3 weeks,the treatment group were additionally treated with 20 mg of trimetazidine by oral,3 times a day,based on the control group.The scores of MMSE,CDR and ADL before treatment and after 1,2 and 3 weeks of treatment and levels of TCH,TG and HCY before and after treatment in two groups were measured.Results: In treatment group,the MMSE score,and CDR and ADL scores increased and decreased gradually after 1,2 and 3 weeks of treatment,respectively.The differences of the all scores between before treatment and after 2 weeks of treatment in treatment group were statistically significant(P<0.01).After 3 weeks of treatment,the total effective rate in treatment group(83.7%) was higher than that in control group(20.4%)(P<0.01).Compared with before treatment,the levels of TCH,TG and HCY in treatment group and levels of TG and HCY in control group were significantly low after treatment(P<0.01).Conclusions: Trimetazidine can reduce the levels of TCH,TG and HCY.Trimetazidine can reduce and treat the ischemic vascular dementia,the treatment effect of which is significant after 2 weeks of treatment.
2015, 40(10): 1375-1377,1381.
Abstract:
Objective: To explore the clinical value of 64 row spiral CT angiography(CTA) in the diagnosis of craniocervical vascular disease.Methods: The 64 row spiral CTA in 72 patients with suspected for craniocervical vascular disease were detected,the primary data of which were imported into ADW4.4 work-station.The craniocervical vessels were analyzed by muti-plane,curved surface and volume reconstruction,and post-processing techniques of maximum intensity projection.Results: Among 72 patients,the cerebral aneurysm in 26 cases,arteriostenosis in 17 cases,aneurysm complicated with artery stenosis in 7 cases,inborn variation of vessel in 8 cases,moyamoya disease in 5 cases,arteriovenous malformation in 4 cases and normal in 5 cases were identified.Conclusions: The 64 row spiral CTA is a noninvasive method,which can clearly display the main artery and its branches,has higher clinical value in the etiological diagnosis of craniocervical vascular disease and prognosis,and play an important guiding role in clinical diagnosis and treatment, can be widely popularized and applied.
Objective: To explore the clinical value of 64 row spiral CT angiography(CTA) in the diagnosis of craniocervical vascular disease.Methods: The 64 row spiral CTA in 72 patients with suspected for craniocervical vascular disease were detected,the primary data of which were imported into ADW4.4 work-station.The craniocervical vessels were analyzed by muti-plane,curved surface and volume reconstruction,and post-processing techniques of maximum intensity projection.Results: Among 72 patients,the cerebral aneurysm in 26 cases,arteriostenosis in 17 cases,aneurysm complicated with artery stenosis in 7 cases,inborn variation of vessel in 8 cases,moyamoya disease in 5 cases,arteriovenous malformation in 4 cases and normal in 5 cases were identified.Conclusions: The 64 row spiral CTA is a noninvasive method,which can clearly display the main artery and its branches,has higher clinical value in the etiological diagnosis of craniocervical vascular disease and prognosis,and play an important guiding role in clinical diagnosis and treatment, can be widely popularized and applied.
2015, 40(10): 1378-1381.
Abstract:
Objective: To explore the characteristics of spiral CT of lymph nodes metastases in gastric cancer,and provide the evidence for formulating clinical treatment schedule and analyzing the prognosis.Methods: Forty-eight patients with advanced gastric cancer before operation were detected by plain and tri-phasic enhanced spiral CT scan.The potential lymph node metastasis was evaluated by the long diameter,ratio of short to long diameter,density and enhanced degree of lymph nodes,which was compared with the postoperative pathological findings.Results: A long diameter more than or equal to 8 mm,ratio of short-to-long diameter more than or equal to 0.7,CT value more than or equal to 25 HU and enhanced degree more than or equal to 75 Hu of lymph nodes could be as the CT diagnostic standard of lymph node metastasis,which was in consistency with the postoperative pathological findings.Conclusions: The long diameter,ratio of short to long diameter,density and enhanced degree of lymph nodes in tri-phasic enhanced spiral CT scan can diagnose the lymph node metastasis of gastric cancer before operation,which has important value in selecting surgical method and analyzing prognosis.
Objective: To explore the characteristics of spiral CT of lymph nodes metastases in gastric cancer,and provide the evidence for formulating clinical treatment schedule and analyzing the prognosis.Methods: Forty-eight patients with advanced gastric cancer before operation were detected by plain and tri-phasic enhanced spiral CT scan.The potential lymph node metastasis was evaluated by the long diameter,ratio of short to long diameter,density and enhanced degree of lymph nodes,which was compared with the postoperative pathological findings.Results: A long diameter more than or equal to 8 mm,ratio of short-to-long diameter more than or equal to 0.7,CT value more than or equal to 25 HU and enhanced degree more than or equal to 75 Hu of lymph nodes could be as the CT diagnostic standard of lymph node metastasis,which was in consistency with the postoperative pathological findings.Conclusions: The long diameter,ratio of short to long diameter,density and enhanced degree of lymph nodes in tri-phasic enhanced spiral CT scan can diagnose the lymph node metastasis of gastric cancer before operation,which has important value in selecting surgical method and analyzing prognosis.
2015, 40(10): 1382-1384.
Abstract:
Objective: To investigate the relationships between the different spectrum wave types of early pregnancy fetal venous catheter,and fetal growth and prognosis.Methods: The blood flow spectrum of venous catheter in 100 fetuses were monitored.The different spectrum wave types were divided into Ⅰ,Ⅱ and Ⅲ type according to the blood flow of venous catheter.The relationships between the different spectrum wave types,and congenital diseases and fetal growth were analyzed.Results: The fetus with type Ⅲ wave may have congenital disease,the sensitivity and specificity of which were 85.7% and 98.90%,respectively.The type Ⅱ was more common in the fetus with less than or equal to 60 cm of brachiocephalic length.Conclusions: The wave types of venous catheter in early pregnancy period can be used one of the standard in judging the growth and development of fetus.
Objective: To investigate the relationships between the different spectrum wave types of early pregnancy fetal venous catheter,and fetal growth and prognosis.Methods: The blood flow spectrum of venous catheter in 100 fetuses were monitored.The different spectrum wave types were divided into Ⅰ,Ⅱ and Ⅲ type according to the blood flow of venous catheter.The relationships between the different spectrum wave types,and congenital diseases and fetal growth were analyzed.Results: The fetus with type Ⅲ wave may have congenital disease,the sensitivity and specificity of which were 85.7% and 98.90%,respectively.The type Ⅱ was more common in the fetus with less than or equal to 60 cm of brachiocephalic length.Conclusions: The wave types of venous catheter in early pregnancy period can be used one of the standard in judging the growth and development of fetus.
2015, 40(10): 1387-1389.
Abstract:
Objective: To explore the correlation between hepatitis B virus(HBV)-DNA load and routine serum markers in patients with HBV infection.Methods: The serum HBV-DNA,hepatitis B virus surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg) and alanine aminotransferase(ALT) in 214 patients with HBV infection were detected using TaqMan real time polymerase chain reaction,chemiluminescence and rate assay.The relationship between the markers were analyzed.Results: Among the 214 patients,the positive rates of HBV-DNA and HBeAg were 57.48% and 28.04%,respectively.The HBV-DNA load was not related to HBsAg and ALT(P>0.05),and was closely related to the HBeAg level(P<0.01).The levels of HBeAg and ALT in positive HBV-DNA group were significantly higher than those in negative HBV-DNA group(P<0.01).Conclusions: The HBV-DNA load is positive correlation with the HBeAg level,and is not correlation with HBsAg and ALT.The HBsAg level standing for HBsAg still nends be further validated
Objective: To explore the correlation between hepatitis B virus(HBV)-DNA load and routine serum markers in patients with HBV infection.Methods: The serum HBV-DNA,hepatitis B virus surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg) and alanine aminotransferase(ALT) in 214 patients with HBV infection were detected using TaqMan real time polymerase chain reaction,chemiluminescence and rate assay.The relationship between the markers were analyzed.Results: Among the 214 patients,the positive rates of HBV-DNA and HBeAg were 57.48% and 28.04%,respectively.The HBV-DNA load was not related to HBsAg and ALT(P>0.05),and was closely related to the HBeAg level(P<0.01).The levels of HBeAg and ALT in positive HBV-DNA group were significantly higher than those in negative HBV-DNA group(P<0.01).Conclusions: The HBV-DNA load is positive correlation with the HBeAg level,and is not correlation with HBsAg and ALT.The HBsAg level standing for HBsAg still nends be further validated
2015, 40(10): 1390-1391,1394.
Abstract:
Objective: To investigate the effects of the increasing of white blood cells(WBC) on the hemoglobin(Hb) level.Methods: The Hb values of 90 blood specimens[WBC value for (10 to <20)×109/L in 30 cases,(20 to <40)×109/L in 30 cases and ≥40×109/L in 30 cases] were determined by XE-2100 blood analyzer and the reference method of hemoglobinometry(HiCN colorimetric method).The turbidity of specimen was measured at the 660 nm wave length of spectrophotometer by HiCN colorimetric method,the WBC in specimens were removed by high-speed centrifuge,and then the Hb values in supernatant were determined by the colorimetric method.The Hb values between before and after centrifuge were compared.Results: The effects of the WBC value≥40×109/L on Hb was great.With the increase of the WBC value,the turbidity was more higher,and the effect of Hb was the more obvious(P<0.05).Conclusions: The high WBC can increase the false Hb value.The effects of the abnormal increasing of WBC on Hb value can be eliminated by the HiCN diluting blood,high-speed centrifuge to removing WBC and colorimetric assay.
Objective: To investigate the effects of the increasing of white blood cells(WBC) on the hemoglobin(Hb) level.Methods: The Hb values of 90 blood specimens[WBC value for (10 to <20)×109/L in 30 cases,(20 to <40)×109/L in 30 cases and ≥40×109/L in 30 cases] were determined by XE-2100 blood analyzer and the reference method of hemoglobinometry(HiCN colorimetric method).The turbidity of specimen was measured at the 660 nm wave length of spectrophotometer by HiCN colorimetric method,the WBC in specimens were removed by high-speed centrifuge,and then the Hb values in supernatant were determined by the colorimetric method.The Hb values between before and after centrifuge were compared.Results: The effects of the WBC value≥40×109/L on Hb was great.With the increase of the WBC value,the turbidity was more higher,and the effect of Hb was the more obvious(P<0.05).Conclusions: The high WBC can increase the false Hb value.The effects of the abnormal increasing of WBC on Hb value can be eliminated by the HiCN diluting blood,high-speed centrifuge to removing WBC and colorimetric assay.
2015, 40(10): 1392-1394.
Abstract:
Objective: To explore the clinical significance of Treponema pallidum-enzyme linked immunosorbent assay(TP-ELISA),syphilis toluidine red untreated serum test(TRUST) and treponemapallidum particle agglutination assay(TPPA) in the diagnosis of syphilis.Methods: The syphilis in the clinical samples were screened by TP-ELISA,and the 93 positive specimens and 16 specimens with the 0.80 to 0.99 of S/CO value were further confirmed by TRUST and TPPA.Results: Among the 93 positive specimens,83 positive cases and 6 weakly positive were identified by TPPA,the positive coincidence rate of which was 95.70%(89/93).Among 93 positive syphilis cases detected by TP-ELISA,the 32 TRUST positive cases were confirmed,and which was positive by the TPPA detection too.Among the 61 weakly positive samples detected by TRUST,the 51 positive cases,6 weakly positive cases and 4 negative cases were identified by TPPA.Among 16 cases with the 0.80 to 0.99 of S/CO value,the 1 positive case and 1 weakly positive case were identified by TPPA.Conclusions: The syphilis screened by TP-ELISA exists false positive and false negative.The TRUST should be tested in TP-ELISA positive specimens at first,and the TPPA in negative TRUST specimen should be further detected to identify.The TPPA in specimens with the 0.80 to 0.99 of S/CO value should be further detected to decrease the misdiagnosis and missed diagnosis rates of syphilis.
Objective: To explore the clinical significance of Treponema pallidum-enzyme linked immunosorbent assay(TP-ELISA),syphilis toluidine red untreated serum test(TRUST) and treponemapallidum particle agglutination assay(TPPA) in the diagnosis of syphilis.Methods: The syphilis in the clinical samples were screened by TP-ELISA,and the 93 positive specimens and 16 specimens with the 0.80 to 0.99 of S/CO value were further confirmed by TRUST and TPPA.Results: Among the 93 positive specimens,83 positive cases and 6 weakly positive were identified by TPPA,the positive coincidence rate of which was 95.70%(89/93).Among 93 positive syphilis cases detected by TP-ELISA,the 32 TRUST positive cases were confirmed,and which was positive by the TPPA detection too.Among the 61 weakly positive samples detected by TRUST,the 51 positive cases,6 weakly positive cases and 4 negative cases were identified by TPPA.Among 16 cases with the 0.80 to 0.99 of S/CO value,the 1 positive case and 1 weakly positive case were identified by TPPA.Conclusions: The syphilis screened by TP-ELISA exists false positive and false negative.The TRUST should be tested in TP-ELISA positive specimens at first,and the TPPA in negative TRUST specimen should be further detected to identify.The TPPA in specimens with the 0.80 to 0.99 of S/CO value should be further detected to decrease the misdiagnosis and missed diagnosis rates of syphilis.
2015, 40(10): 1395-1398.
Abstract:
Objective: To investigate the infection rate of human papillomavirus(HPV),its genotype and age characteristics among women in Chuzhou area.Methods: Twenty-three genotypes in cervical secretion or castoff cells in 2 554 women from Chuzhou area were detected using PCR-reverse dot blot.Results: Among 2 554 patients,557 cases with positive HPV infection were detected,the infection rate of which was 21.81%,and the 82 genotype was not detected.The single infection,dual infection and more than triple infection rates of HPV were 16.33%,3.92% and 1.57%,respectively.HPV16,58 and 52 were the most prevalent types in the positive cases with high risk genotype,HPV43 and 81 were the most prevalent types in the positive cases with low risk genotype.Among 23 genotypes,the infection rates of HPV16,58,43,52 and 81 were the first five in turn.The peak age of infection was mainly distributed in 19 to 30 years old women.The infection rates of HPV16 and HPV16 mixed with other subtypes were 3.99% and 1.61%,respectively.The peak ages of the infection of HPV16,single infection and more than triple infection of HPV,and dual infection were 61 to 70,19 to 30 and 51 to 60 years old.Conclusions: The HPV16,58 and 43 in HPV infection among women from Chuzhou area are the mainly popular subtypes,the HPV infection is on the rise,and the age of onset tends to be younger.
Objective: To investigate the infection rate of human papillomavirus(HPV),its genotype and age characteristics among women in Chuzhou area.Methods: Twenty-three genotypes in cervical secretion or castoff cells in 2 554 women from Chuzhou area were detected using PCR-reverse dot blot.Results: Among 2 554 patients,557 cases with positive HPV infection were detected,the infection rate of which was 21.81%,and the 82 genotype was not detected.The single infection,dual infection and more than triple infection rates of HPV were 16.33%,3.92% and 1.57%,respectively.HPV16,58 and 52 were the most prevalent types in the positive cases with high risk genotype,HPV43 and 81 were the most prevalent types in the positive cases with low risk genotype.Among 23 genotypes,the infection rates of HPV16,58,43,52 and 81 were the first five in turn.The peak age of infection was mainly distributed in 19 to 30 years old women.The infection rates of HPV16 and HPV16 mixed with other subtypes were 3.99% and 1.61%,respectively.The peak ages of the infection of HPV16,single infection and more than triple infection of HPV,and dual infection were 61 to 70,19 to 30 and 51 to 60 years old.Conclusions: The HPV16,58 and 43 in HPV infection among women from Chuzhou area are the mainly popular subtypes,the HPV infection is on the rise,and the age of onset tends to be younger.
2015, 40(10): 1401-1403.
Abstract:
Objective: To evaluate the clinical application of docetaxel using projection persuit method.Methods: The evaluation criterion of docetaxel use was formulated.Two hundred and nineteen docetaxel precriptions from Jan to Mar 2014 in a tertiary hospital were statistically analyzed and discussed by projection pursuit method.Results: The effects of the medication order,pretreatment and dosage on the application assessment of docetaxel were large by the analysis of one dimension projection value.The reasonable percentage with more than 90% accounted for 89.97% by analyzing the doctor's advice comments.Among all doctor's advice comments,the lowest percentage was 86.93%.Among 78 cases,the Ci for 1 in 55 cases(70.51%),between 0.95 and 1 in 5 cases(6.41%),between 0.90 to 0.95 in 10 cases(12.82%) and between 0.85 and 0.90 in 8 cases(10.26%) were identified.Conclusions: The rationality analysis of using docetaxel by projection pursuit method can quantitatively analyze the accuracy and rationality of drug prescription,provide effective drug use programme in clinic and quality of life of patients.
Objective: To evaluate the clinical application of docetaxel using projection persuit method.Methods: The evaluation criterion of docetaxel use was formulated.Two hundred and nineteen docetaxel precriptions from Jan to Mar 2014 in a tertiary hospital were statistically analyzed and discussed by projection pursuit method.Results: The effects of the medication order,pretreatment and dosage on the application assessment of docetaxel were large by the analysis of one dimension projection value.The reasonable percentage with more than 90% accounted for 89.97% by analyzing the doctor's advice comments.Among all doctor's advice comments,the lowest percentage was 86.93%.Among 78 cases,the Ci for 1 in 55 cases(70.51%),between 0.95 and 1 in 5 cases(6.41%),between 0.90 to 0.95 in 10 cases(12.82%) and between 0.85 and 0.90 in 8 cases(10.26%) were identified.Conclusions: The rationality analysis of using docetaxel by projection pursuit method can quantitatively analyze the accuracy and rationality of drug prescription,provide effective drug use programme in clinic and quality of life of patients.
2015, 40(10): 1404-1407.
Abstract:
Objective: To understand the clinical manifestations and characteristics of the adverse drug reaction(ADR),provide references for rational drug in clinics.Methods: Totally 161 ADR reports during Aug.to Oct.in 2014 were analyzed statistically in respect of patients' age,route of administration,drug type,organs or systems involved and clinical manifestation of the ADR,the missing essential information elements in reports.Results: Patients who were<18 years old and > 60 years old,had a higher proportion of ADR(26 case,16.1%;63 case,39.1%);89 cases(55.3%) were induced by intravenous route of administration;37 cases(23.0%) were occurred ADR with traditional Chinese medicines at most;the majority of ADR was skin destructon,which had 49 cases(30.4%);the proportion of pharmacists was significantly higher than that of physicians and nurses.Conclusions: ADR reporting and monitoring is crucial in reduceing or avoiding ADR and promote rational drug use,improve patient medication safety.
Objective: To understand the clinical manifestations and characteristics of the adverse drug reaction(ADR),provide references for rational drug in clinics.Methods: Totally 161 ADR reports during Aug.to Oct.in 2014 were analyzed statistically in respect of patients' age,route of administration,drug type,organs or systems involved and clinical manifestation of the ADR,the missing essential information elements in reports.Results: Patients who were<18 years old and > 60 years old,had a higher proportion of ADR(26 case,16.1%;63 case,39.1%);89 cases(55.3%) were induced by intravenous route of administration;37 cases(23.0%) were occurred ADR with traditional Chinese medicines at most;the majority of ADR was skin destructon,which had 49 cases(30.4%);the proportion of pharmacists was significantly higher than that of physicians and nurses.Conclusions: ADR reporting and monitoring is crucial in reduceing or avoiding ADR and promote rational drug use,improve patient medication safety.
2015, 40(10): 1408-1411.
Abstract:
Objective: To analyze the overall psychological health status of clinical interns by the questionnaire survey and data analysis.Methods: The demographic data and psychological health status of 457 clinical interns from Bengbu Medical College were surveyed using the questionnaire methods(including the Basic-Data-Company and SCL-90 scale).Results: The scores of the somatization,anxiety and phobic factors of SCL-90 in clinical interns were higher than those in national college norm and youth norm(P<0.01).The scores of the forced symptoms,depression,hostility,paranoia and psychosis in clinical interns were significantly lower than those in national college norm and higher than those in national youth norm(P<0.01).Girl students are found higher in SCL-90 score in terms of depression(P<0.05 to P<0.01),anxiety and phobic anxiety while boy students with higher score in terms of hostility(P<0.05).Students from rural area are found higher in SCL-90 score in terms of interpersonal sensitivity,anxiety and paranoid ideation(P<0.01).Students from single-parent family are found with higher score in terms of all factors(P<0.05 to P<0.01).There are no significant differences between students who are or are not going to attend Master's degree exam(P>0.05).Conclusions: The levels of psychological health status of clinical interns from the second department of clinical medicine of Bengbu Medical College are slightly lower than those in national college norm and national youth norm,and the levels of psychological health status of clinical interns in different gender,origin and family structure are different.
Objective: To analyze the overall psychological health status of clinical interns by the questionnaire survey and data analysis.Methods: The demographic data and psychological health status of 457 clinical interns from Bengbu Medical College were surveyed using the questionnaire methods(including the Basic-Data-Company and SCL-90 scale).Results: The scores of the somatization,anxiety and phobic factors of SCL-90 in clinical interns were higher than those in national college norm and youth norm(P<0.01).The scores of the forced symptoms,depression,hostility,paranoia and psychosis in clinical interns were significantly lower than those in national college norm and higher than those in national youth norm(P<0.01).Girl students are found higher in SCL-90 score in terms of depression(P<0.05 to P<0.01),anxiety and phobic anxiety while boy students with higher score in terms of hostility(P<0.05).Students from rural area are found higher in SCL-90 score in terms of interpersonal sensitivity,anxiety and paranoid ideation(P<0.01).Students from single-parent family are found with higher score in terms of all factors(P<0.05 to P<0.01).There are no significant differences between students who are or are not going to attend Master's degree exam(P>0.05).Conclusions: The levels of psychological health status of clinical interns from the second department of clinical medicine of Bengbu Medical College are slightly lower than those in national college norm and national youth norm,and the levels of psychological health status of clinical interns in different gender,origin and family structure are different.
2015, 40(10): 1412-1414,1419.
Abstract:
Objective: To explore and practice the biochemistry inquiry teaching according to the “excellent doctor” training program.Methods: The biochemistry inquiry teaching was carried out in “excellent doctor education reform experimental class” of clinical medicine specialty of Bengbu Medical College,the teaching effect was compared with the traditional teaching method.Results: The ability of independent learning,consciousness of innovation,critical thinking,spirit of teamwork,ability of language expression,communication and ability of reading literature in experimental class were significantly better than those in control class(P<0.01).Conclusions: The effects of inquiry teaching on the abilitiy of solving problem and innovation are better than whose of traditional teaching,which is beneficial to the development of the “excellent doctor”.
Objective: To explore and practice the biochemistry inquiry teaching according to the “excellent doctor” training program.Methods: The biochemistry inquiry teaching was carried out in “excellent doctor education reform experimental class” of clinical medicine specialty of Bengbu Medical College,the teaching effect was compared with the traditional teaching method.Results: The ability of independent learning,consciousness of innovation,critical thinking,spirit of teamwork,ability of language expression,communication and ability of reading literature in experimental class were significantly better than those in control class(P<0.01).Conclusions: The effects of inquiry teaching on the abilitiy of solving problem and innovation are better than whose of traditional teaching,which is beneficial to the development of the “excellent doctor”.
2015, 40(10): 1415-1419.
Abstract:
Objective: To explore the teaching effectiveness in Medical English under social constructivist perspective of learning.Methods: Class A(182 students) and class B(188 students) from grade 2012 clinical specialty were divided into the experimental group and control group,respectively.The experimental group and control group in Medical English were taught using social constructive perspective of learning and vocabulary teaching combined with grammar-translation method,respectively.The implementation and evaluation of effective teaching method were investigated from 3 dimensions of teaching objective,teaching activities and reflective learning.Results: The final score of the experimental group was significantly higher than that of the control group(P<0.01).The satisfaction and teaching quality of Medical English in “learner-center” were improved.Conclusions: Effective teaching is favorable for the active construction of significance of autonomous Learning and research in learner,which can provide useful inspiration in the further development of teaching reform.
Objective: To explore the teaching effectiveness in Medical English under social constructivist perspective of learning.Methods: Class A(182 students) and class B(188 students) from grade 2012 clinical specialty were divided into the experimental group and control group,respectively.The experimental group and control group in Medical English were taught using social constructive perspective of learning and vocabulary teaching combined with grammar-translation method,respectively.The implementation and evaluation of effective teaching method were investigated from 3 dimensions of teaching objective,teaching activities and reflective learning.Results: The final score of the experimental group was significantly higher than that of the control group(P<0.01).The satisfaction and teaching quality of Medical English in “learner-center” were improved.Conclusions: Effective teaching is favorable for the active construction of significance of autonomous Learning and research in learner,which can provide useful inspiration in the further development of teaching reform.
2015, 40(10): 1420-1422.
Abstract:
Objective: To explore the reasons for emergency nurse's leaving,and to provide the basis for hospital managers in reducing the turnover rate.Methods: Twelve leaving emergency nurses were semi-structured individual interviewed using qualitative research method,the result of which was analyzed.Results: The subject was refined by listening to recording,analyzing and confirming.The work environment and property,immature management system,supports from social and family,low organizational commitment and high competency were the main factors.Conclusions: Nurse managers should create the harmonious working environment and provide the emotional support to reduce the turnover rate.
Objective: To explore the reasons for emergency nurse's leaving,and to provide the basis for hospital managers in reducing the turnover rate.Methods: Twelve leaving emergency nurses were semi-structured individual interviewed using qualitative research method,the result of which was analyzed.Results: The subject was refined by listening to recording,analyzing and confirming.The work environment and property,immature management system,supports from social and family,low organizational commitment and high competency were the main factors.Conclusions: Nurse managers should create the harmonious working environment and provide the emotional support to reduce the turnover rate.
2015, 40(10): 1423-1425.
Abstract:
Objective: To investigate the leakage of venous transfusion and its influencing factors in a tertiary hospital.Methods: The leakage of venous transfusion in 1 680 patients from ENT in a top tertiary hospital was investigated from Jan 2012 to Jan 2013,the influencing factors of which was analyzed.Results: Among 1 453 patients treated with venous transfusion,49 cases fluid exudation from 38 patients were found,the fluid exudation rate,annual incidence and incidence density were 2.62%,3.37% and 1.29,respectively.The differences of the leakage of venous transfusion rate in different gender,age,infusion device,length of service,the first infusion and caregiver on the day were statistically significant(P<0.05 to P<0.01).The male patients,children and older people,no caregiver on the day and lower length of service were the risk factors of leakage of venous transfusion(P<0.05 to P<0.01).Conclusions: The male patients,children and the elderly patients need to strengthen patrol during the venous transfusion,primary nurse should inform the importance of the hospital care for patients.Improving the intravenous infusion skill of lower length of service nurse,and strict observating the puncture local skin can reduce the incidence of venous leakage.
Objective: To investigate the leakage of venous transfusion and its influencing factors in a tertiary hospital.Methods: The leakage of venous transfusion in 1 680 patients from ENT in a top tertiary hospital was investigated from Jan 2012 to Jan 2013,the influencing factors of which was analyzed.Results: Among 1 453 patients treated with venous transfusion,49 cases fluid exudation from 38 patients were found,the fluid exudation rate,annual incidence and incidence density were 2.62%,3.37% and 1.29,respectively.The differences of the leakage of venous transfusion rate in different gender,age,infusion device,length of service,the first infusion and caregiver on the day were statistically significant(P<0.05 to P<0.01).The male patients,children and older people,no caregiver on the day and lower length of service were the risk factors of leakage of venous transfusion(P<0.05 to P<0.01).Conclusions: The male patients,children and the elderly patients need to strengthen patrol during the venous transfusion,primary nurse should inform the importance of the hospital care for patients.Improving the intravenous infusion skill of lower length of service nurse,and strict observating the puncture local skin can reduce the incidence of venous leakage.
2015, 40(10): 1426-1429.
Abstract:
Objective: To explore the effects of the nursing intervention on improving the postoperative pain in patients with ENT(ear,nose and throat)surgery.Methods: Fifty patients treated with ENT surgery were set as the observation group,and nursed with comprehensive nursing intervention.Fifty patients treated with ENT surgery from March 2011 to August 2012 were set as the control group,and nursed with the conventional nursing method.The visual analogue scale score at postoperative 24 h and 72 h,and analgesic usage rate,pain level proportion and total efficacy at postoperative 72 h in two groups were observed.Results: The visual analogue scale score at postoperative 24 h and 72 h and analgesic usage rate at postoperative 72 h in observation group were significantly lower than those in control group(P<0.01).The total rate of pain in observation group and control group were 12.0% and 68.0%,respectively,the difference of which was statistically significant(P<0.01).The totally effective rate in observation group and control group were 100.0% and 90.0%,respectively,the difference of which was statistically significant(P<0.01).Conclusions: Comprehensive nursing intervention can effectively improve the postoperative pain,and promote the postoperative recovery of patients,which is worthy of popularizing.
Objective: To explore the effects of the nursing intervention on improving the postoperative pain in patients with ENT(ear,nose and throat)surgery.Methods: Fifty patients treated with ENT surgery were set as the observation group,and nursed with comprehensive nursing intervention.Fifty patients treated with ENT surgery from March 2011 to August 2012 were set as the control group,and nursed with the conventional nursing method.The visual analogue scale score at postoperative 24 h and 72 h,and analgesic usage rate,pain level proportion and total efficacy at postoperative 72 h in two groups were observed.Results: The visual analogue scale score at postoperative 24 h and 72 h and analgesic usage rate at postoperative 72 h in observation group were significantly lower than those in control group(P<0.01).The total rate of pain in observation group and control group were 12.0% and 68.0%,respectively,the difference of which was statistically significant(P<0.01).The totally effective rate in observation group and control group were 100.0% and 90.0%,respectively,the difference of which was statistically significant(P<0.01).Conclusions: Comprehensive nursing intervention can effectively improve the postoperative pain,and promote the postoperative recovery of patients,which is worthy of popularizing.
2015, 40(10): 1429-1431.
Abstract:
Objective: To investigate the status and its influencing factors of humanistic caring ability in orthopaedic nursing staff.Methods: Forty-eight orthopaedic nursing staff from two tertiary hospitals in a city were investigated by self-designed questionnaire.Results: The humanistic caring ability of nurse with more than or equal to 40 years old was higher than that of nurse with less than 40 years old(P<0.01).The humanistic caring ability of nurse with more than or equal to 10 years service was higher than that of nurse with less than 10 years service(P<0.01).The humanistic caring ability of nurse with nurse professional title or above was higher than that of nurse(P<0.01).The humanistic caring ability of nurse with bachelor degree was higher than that from nursing school(P<0.01).Conclusions: The age,professional title,education and working years are the influence factors of humanistic caring ability in orthopaedic nursing staff.The hierarchical continuing education training should be implemented by nursing managers according to the different influencing factors,which can constantly improve the orthopedic humanistic caring ability,and provide high quality nursing service.
Objective: To investigate the status and its influencing factors of humanistic caring ability in orthopaedic nursing staff.Methods: Forty-eight orthopaedic nursing staff from two tertiary hospitals in a city were investigated by self-designed questionnaire.Results: The humanistic caring ability of nurse with more than or equal to 40 years old was higher than that of nurse with less than 40 years old(P<0.01).The humanistic caring ability of nurse with more than or equal to 10 years service was higher than that of nurse with less than 10 years service(P<0.01).The humanistic caring ability of nurse with nurse professional title or above was higher than that of nurse(P<0.01).The humanistic caring ability of nurse with bachelor degree was higher than that from nursing school(P<0.01).Conclusions: The age,professional title,education and working years are the influence factors of humanistic caring ability in orthopaedic nursing staff.The hierarchical continuing education training should be implemented by nursing managers according to the different influencing factors,which can constantly improve the orthopedic humanistic caring ability,and provide high quality nursing service.
2015, 40(10): 1432-1434.
Abstract:
Objective: To investigate the locating tip accuracy of peripherally inserted center catheter(PICC) using electrocardiography(EKG) monitor in neonates.Methods: The EKG monitor in 40 neonates accorded with the PICC indications was implemented before the tube placement,the lead Ⅱ of EKG monitor was regulated to show normal EKG.The 10 ml syringe connecting with 5.5 scalp needle and heparin cap was connected to the end of PICC.The prediction length of PICC was connected with the right chest clip.The catheter tip in the superior vena cava was judged by P wave of EKG monitor,the accuracy of locating tip of PICC was judged by chest X-ray.Results: Among the 40 cases,the characteristic changes of P wave in 32 patients were identified,which was showed in the middle and low segment of superior vena cava by chest X-ray.The chest X-ray showed that 4 cases were off position,3 cases in 4 uncertainty cases were off position,and 1 case located in the lower of right atrium.The accuracy of the locating tip of PICC using EKG monitor was 92.5%.Conclusions: The characteristic P wave can judge the PICC tip locating in the middle and low segment of upper venous cavity.No characteristic P wave or uncertain judgment hint that the tube tip is heterotopia.
Objective: To investigate the locating tip accuracy of peripherally inserted center catheter(PICC) using electrocardiography(EKG) monitor in neonates.Methods: The EKG monitor in 40 neonates accorded with the PICC indications was implemented before the tube placement,the lead Ⅱ of EKG monitor was regulated to show normal EKG.The 10 ml syringe connecting with 5.5 scalp needle and heparin cap was connected to the end of PICC.The prediction length of PICC was connected with the right chest clip.The catheter tip in the superior vena cava was judged by P wave of EKG monitor,the accuracy of locating tip of PICC was judged by chest X-ray.Results: Among the 40 cases,the characteristic changes of P wave in 32 patients were identified,which was showed in the middle and low segment of superior vena cava by chest X-ray.The chest X-ray showed that 4 cases were off position,3 cases in 4 uncertainty cases were off position,and 1 case located in the lower of right atrium.The accuracy of the locating tip of PICC using EKG monitor was 92.5%.Conclusions: The characteristic P wave can judge the PICC tip locating in the middle and low segment of upper venous cavity.No characteristic P wave or uncertain judgment hint that the tube tip is heterotopia.
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