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2015 Vol. 40, No. 9
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2015, 40(9): 1145-1147,1151.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.001
Abstract:
Objective:To investigate the effect of Mycobacterium tuberculosis(Mtb) on the function of mouse bone marrow derived dendritic cells(DC).Methods:DC were divided into 4 groups,lipopolysaccharide(LPS)-treated group,Mtb-treated group,inactivated Mtb-treated group and control group.Cytokines including interleukin(IL)-6,IL-12 and tumor necrosis factor α secretion of infected cells were examined by ELISA method.And the expression of surface molecules of infected DC including major histocompatibility complex class Ⅱ,CD40,CD80 and CD86 were detected by flow cytometry.Results:About 5×106 to 1×107 DC were obtained from bone marrow of one mouse,and the purity of DC was more than 85%.The cells had the typical morphology of DC.The expressions of major histocompatibility complex class Ⅱ,CD40,CD80 and CD86 on stimulated DC increased in LPS-treated group,Mtb-treated group,inactivated Mtb-treated group in contrast to control group;while the percentage of the upregulation of surface molecules in Mtb-treated DC was significantly lower than that of LPS or inactivated Mtb-treated DC.The cytokine levels in all groups significantly increased,and IL-6,IL-12 and tumor necrosis factor α secretions of DC infected by Mtb were significantly lower than those of LPS or inactivated Mtb-treated DC.Conclusions:Mtb can decrease the antigen presenting function through interfering the secretion of cytokines and inhibiting maturation of DC,and consequently suppress DC and T cell activation and result in the more serious damage of host.
Objective:To investigate the effect of Mycobacterium tuberculosis(Mtb) on the function of mouse bone marrow derived dendritic cells(DC).Methods:DC were divided into 4 groups,lipopolysaccharide(LPS)-treated group,Mtb-treated group,inactivated Mtb-treated group and control group.Cytokines including interleukin(IL)-6,IL-12 and tumor necrosis factor α secretion of infected cells were examined by ELISA method.And the expression of surface molecules of infected DC including major histocompatibility complex class Ⅱ,CD40,CD80 and CD86 were detected by flow cytometry.Results:About 5×106 to 1×107 DC were obtained from bone marrow of one mouse,and the purity of DC was more than 85%.The cells had the typical morphology of DC.The expressions of major histocompatibility complex class Ⅱ,CD40,CD80 and CD86 on stimulated DC increased in LPS-treated group,Mtb-treated group,inactivated Mtb-treated group in contrast to control group;while the percentage of the upregulation of surface molecules in Mtb-treated DC was significantly lower than that of LPS or inactivated Mtb-treated DC.The cytokine levels in all groups significantly increased,and IL-6,IL-12 and tumor necrosis factor α secretions of DC infected by Mtb were significantly lower than those of LPS or inactivated Mtb-treated DC.Conclusions:Mtb can decrease the antigen presenting function through interfering the secretion of cytokines and inhibiting maturation of DC,and consequently suppress DC and T cell activation and result in the more serious damage of host.
2015, 40(9): 1148-1151.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.002
Abstract:
Objective:To observe the distribution of Vδ1 to 8 subsets of the T cell receptor(TCR) molecule in the γδT cell of the human peripheral blood using real-time PCR.Methods:The mRNA expressions of the Vδ1 to 8 subsets of TCR molecule in the γδT cell in 16 healthy people peripheral blood were detected by real-time PCR,the respective percentage of whose were calculated.Results:The ratio of Vδ1,2,3,4,5,6,7 and 8 subsets were(7.19±0.33)%,(54.27±7.9)%,(20.23±0.03)%,(3.80±0.02)%,(2.08±0.02)%,(0.81±0.25)%,(7.21±0.02)% and(4.41±0.04)%,respectively.The ratio of Vδ2 was significantly higher than that in other subsets(P<0.05).Conclusions:The distribution sequence from most to least of Vδ1 to 8 subsets of the TCR molecule in the γδT cell of the healthy people peripheral blood is Vδ2 >Vδ3 >Vδ1 >δV8 >Vδ7 >Vδ4 >Vδ5 >Vδ6.
Objective:To observe the distribution of Vδ1 to 8 subsets of the T cell receptor(TCR) molecule in the γδT cell of the human peripheral blood using real-time PCR.Methods:The mRNA expressions of the Vδ1 to 8 subsets of TCR molecule in the γδT cell in 16 healthy people peripheral blood were detected by real-time PCR,the respective percentage of whose were calculated.Results:The ratio of Vδ1,2,3,4,5,6,7 and 8 subsets were(7.19±0.33)%,(54.27±7.9)%,(20.23±0.03)%,(3.80±0.02)%,(2.08±0.02)%,(0.81±0.25)%,(7.21±0.02)% and(4.41±0.04)%,respectively.The ratio of Vδ2 was significantly higher than that in other subsets(P<0.05).Conclusions:The distribution sequence from most to least of Vδ1 to 8 subsets of the TCR molecule in the γδT cell of the healthy people peripheral blood is Vδ2 >Vδ3 >Vδ1 >δV8 >Vδ7 >Vδ4 >Vδ5 >Vδ6.
2015, 40(9): 1152-1154,1155.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.003
Abstract:
Objective:To observe the preemptive analgesia effects of lornoxicam combined with dezocine on the rat with incision pain,and investigate its possible mechanism.Methods:Forty Wistar rats were randomly divided into the control group(without any treatment),incision pain model group(treatment with preoperative 30 min tail vein injection of saline),lornoxicam group(treatment with preoperative 30 min tail vein injection of 2 mg/kg of lornoxicam),dezocine group(treatment with preoperative 30min tail vein injection of 5 mg of lornoxicam) and lornoxicam combined with dezocine group(treatment with preoperative 30 min tail vein injection of 1 mg/kg of lornoxicam combined with 2.5 mg of lornoxicam).The pain score of rats with incision pain after operation was investigated using the cumulative pain score method.The interleukin(IL)-6 expression in the rat tail vein and cyclooxygenase(COX)-2 level in spinal cord were measured after 3h of operation.Results:The cumulative pain score in incision pain model group was significantly higher than that in lornoxicam group,dezocine group and lornoxicam combined with dezocine group(P<0.01).The cumulative pain score in lornoxicam combined with dezocine group was significantly lower than that in single drug group(P<0.01).The expressions of serum IL-6 and COX-2 in spinal cord in lornoxicam combined with dezocine group were significantly lower than that in single drug group(P<0.01).Conclusions:Lornoxicam combined with dezocine can inhibit the expressions of serum IL-6 and COX-2 in spinal cord and decrease the pain score in rat with incision pain,which plays the preemptive analgesia effects.
Objective:To observe the preemptive analgesia effects of lornoxicam combined with dezocine on the rat with incision pain,and investigate its possible mechanism.Methods:Forty Wistar rats were randomly divided into the control group(without any treatment),incision pain model group(treatment with preoperative 30 min tail vein injection of saline),lornoxicam group(treatment with preoperative 30 min tail vein injection of 2 mg/kg of lornoxicam),dezocine group(treatment with preoperative 30min tail vein injection of 5 mg of lornoxicam) and lornoxicam combined with dezocine group(treatment with preoperative 30 min tail vein injection of 1 mg/kg of lornoxicam combined with 2.5 mg of lornoxicam).The pain score of rats with incision pain after operation was investigated using the cumulative pain score method.The interleukin(IL)-6 expression in the rat tail vein and cyclooxygenase(COX)-2 level in spinal cord were measured after 3h of operation.Results:The cumulative pain score in incision pain model group was significantly higher than that in lornoxicam group,dezocine group and lornoxicam combined with dezocine group(P<0.01).The cumulative pain score in lornoxicam combined with dezocine group was significantly lower than that in single drug group(P<0.01).The expressions of serum IL-6 and COX-2 in spinal cord in lornoxicam combined with dezocine group were significantly lower than that in single drug group(P<0.01).Conclusions:Lornoxicam combined with dezocine can inhibit the expressions of serum IL-6 and COX-2 in spinal cord and decrease the pain score in rat with incision pain,which plays the preemptive analgesia effects.
2015, 40(9): 1155-1157.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.004
Abstract:
Objective:To investigate the effects of MCI-186 on the expression of cytochrome C(Cyt C) in hippocampus of epilepsy rats induced by kainic acid(KA).Methods:The SD rats were randomly divided into the control group,seizure group,drug control group and MCI-186 group.The seizures model of rats were established by injecting KA into encephalocoele.The Cyt C expressions in cytoplasm and mitochondria were detected using Western-blot.Results:The Cyt C expressions in mitochondria in seizure group and drug control group were lower than that in MCI-186 group(P<0.01).The Cyt C expressions in cytoplasm in seizure group and drug control group were higher than that in MCI-186 group(P<0.01).Conclusions:MCI-186 may decrease the release of Cyt C from mitochondria to cytoplasm,and which can protect the hippocampus by inhibiting the mitochondrial apoptotic pathway.
Objective:To investigate the effects of MCI-186 on the expression of cytochrome C(Cyt C) in hippocampus of epilepsy rats induced by kainic acid(KA).Methods:The SD rats were randomly divided into the control group,seizure group,drug control group and MCI-186 group.The seizures model of rats were established by injecting KA into encephalocoele.The Cyt C expressions in cytoplasm and mitochondria were detected using Western-blot.Results:The Cyt C expressions in mitochondria in seizure group and drug control group were lower than that in MCI-186 group(P<0.01).The Cyt C expressions in cytoplasm in seizure group and drug control group were higher than that in MCI-186 group(P<0.01).Conclusions:MCI-186 may decrease the release of Cyt C from mitochondria to cytoplasm,and which can protect the hippocampus by inhibiting the mitochondrial apoptotic pathway.
2015, 40(9): 1158-1160.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.005
Abstract:
Objective:To analyze the efficacy and safety of oxaliplatin combined with gemcitabine(GEMOX) for treatment of patients with advanced primary liver cancer(PLC).Methods:Thirty patients with advanced PLC received the systemic chemotherapy of GEMOX regimen.The efficacy and toxicity were evaluated every 2 cycles by the criteria of Response Evaluation Criteria in Solid Tumors,version 1.1 and the National cancer institute-common terminology criteria adverse events,version 4.0.Results:All the 30 patients were evaluable for short-term efficacy.Partial response was observed in 2 cases,stability in 22 cases and progression in 6 cases.The objective response rate was 6.7% and the disease control rate was 80.0%.The median time to progression and the overall survival time were 3.9 and 9.4 months,respectively.Clinical symptoms and Karnofsky scores were improved in 25 cases.The main adverse effects were hematologic toxicity,alopecia,mild to moderate gastrointestinal reaction and mild periphery neurotoxicity,which returned to normal after treatment.Conclusions:GEMOX regimen is effective for treatment of advanced PLC with tolerable adverse effects.
Objective:To analyze the efficacy and safety of oxaliplatin combined with gemcitabine(GEMOX) for treatment of patients with advanced primary liver cancer(PLC).Methods:Thirty patients with advanced PLC received the systemic chemotherapy of GEMOX regimen.The efficacy and toxicity were evaluated every 2 cycles by the criteria of Response Evaluation Criteria in Solid Tumors,version 1.1 and the National cancer institute-common terminology criteria adverse events,version 4.0.Results:All the 30 patients were evaluable for short-term efficacy.Partial response was observed in 2 cases,stability in 22 cases and progression in 6 cases.The objective response rate was 6.7% and the disease control rate was 80.0%.The median time to progression and the overall survival time were 3.9 and 9.4 months,respectively.Clinical symptoms and Karnofsky scores were improved in 25 cases.The main adverse effects were hematologic toxicity,alopecia,mild to moderate gastrointestinal reaction and mild periphery neurotoxicity,which returned to normal after treatment.Conclusions:GEMOX regimen is effective for treatment of advanced PLC with tolerable adverse effects.
2015, 40(9): 1161-1163.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.006
Abstract:
Objective:To compare the short-term effects of unicompartmental knee arthroplasty(UKA) and total knee replacement(TKA) in the treatment of unicompartmental osteoarthritis.Methods:Among 24 patients with unicompartmental osteoarthritis,8 cases and 16 cases were treated with UKA and TKA,respectively.The VAS and HSS scores before operation and the end of following up between two groups were compared.Results:The prosthesis of 1 case in TKA group was taken out because of infection.No infection,loosening of the prosthesis,jiont renovation and lower extremity venous thrombosis during the following up period in two groups were found.The VAS and HSS scores in all cases were significantly improved after operation(P<0.01).At the end of following up,the VAS score of postoperative pain relief in TKA patient was better than that in UKA patient(P<0.05),the difference of HSS score between two groups was not statisticaly significant(P>0.05).Conclusions:The short-term effects of UKA and TKA in the treatment of unicompartmental osteoarthritis are similar.The postoperative complication of UKA is little,and the postoperative pain relief of TKA patients is more obvious.
Objective:To compare the short-term effects of unicompartmental knee arthroplasty(UKA) and total knee replacement(TKA) in the treatment of unicompartmental osteoarthritis.Methods:Among 24 patients with unicompartmental osteoarthritis,8 cases and 16 cases were treated with UKA and TKA,respectively.The VAS and HSS scores before operation and the end of following up between two groups were compared.Results:The prosthesis of 1 case in TKA group was taken out because of infection.No infection,loosening of the prosthesis,jiont renovation and lower extremity venous thrombosis during the following up period in two groups were found.The VAS and HSS scores in all cases were significantly improved after operation(P<0.01).At the end of following up,the VAS score of postoperative pain relief in TKA patient was better than that in UKA patient(P<0.05),the difference of HSS score between two groups was not statisticaly significant(P>0.05).Conclusions:The short-term effects of UKA and TKA in the treatment of unicompartmental osteoarthritis are similar.The postoperative complication of UKA is little,and the postoperative pain relief of TKA patients is more obvious.
2015, 40(9): 1164-1165,1170.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.017
Abstract:
Objective:To analyze the clinical effects of terlipressin combined with somatostatin in the treatment of decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract.Methods:Forty-four patients with decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract were randomly divided into the experimental group and control group according to random number table method(22 cases each group).The control group and experimental group were treated with terlipressin and terlipressin combined with somatostatin,respectively.The hemostatic effects,rebleeding,hemostasis time,mortality and hospitalization time between two groups were compared after 48h of treatment.Results:The effective rates of hemostasis in experimental group and control group were 95.4% and 72.7%,respectively,the difference of which was not statistical significance(P>0.05).The blood transfusion volume,hemostasis time and hospitalization time in experimental group were significantly less than those in control group(P<0.01).The differences of the incidence rate of rebleeding and mortality between two groups were not statistical significance(P>0.05).After treatment,the recovery time of blood pressure and urine volume,and speed of stool occult blood turning negative in experimental group were significantly faster than those in control group(P<0.01).The difference of the incidence of adverse reaction between the experimental group(13.6%) and control group(4.6%) was not statistical significance(P>0.05).Conclusions:Terlipressin combined with somatostatin in treating liver decompensation complicated with acute upper gastrointestinal hemorrhage is high hemostatic effectiveness,quick hemostasis time and high safety,which can short hospitalization time and decrease blood transfusion volume.
Objective:To analyze the clinical effects of terlipressin combined with somatostatin in the treatment of decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract.Methods:Forty-four patients with decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract were randomly divided into the experimental group and control group according to random number table method(22 cases each group).The control group and experimental group were treated with terlipressin and terlipressin combined with somatostatin,respectively.The hemostatic effects,rebleeding,hemostasis time,mortality and hospitalization time between two groups were compared after 48h of treatment.Results:The effective rates of hemostasis in experimental group and control group were 95.4% and 72.7%,respectively,the difference of which was not statistical significance(P>0.05).The blood transfusion volume,hemostasis time and hospitalization time in experimental group were significantly less than those in control group(P<0.01).The differences of the incidence rate of rebleeding and mortality between two groups were not statistical significance(P>0.05).After treatment,the recovery time of blood pressure and urine volume,and speed of stool occult blood turning negative in experimental group were significantly faster than those in control group(P<0.01).The difference of the incidence of adverse reaction between the experimental group(13.6%) and control group(4.6%) was not statistical significance(P>0.05).Conclusions:Terlipressin combined with somatostatin in treating liver decompensation complicated with acute upper gastrointestinal hemorrhage is high hemostatic effectiveness,quick hemostasis time and high safety,which can short hospitalization time and decrease blood transfusion volume.
2015, 40(9): 1166-1170.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.008
Abstract:
Objective:To analyze the therapeutic effects of total glucosides of paeony(TGP) for ankylosing spondylitis(AS).Methods:By literature analysis based on evidence-based medicine,randomized controlled trials about TGP in the treatment of AS were obtained from Chine National Knowledge infrastructure,VIP and PubMed.Evaluated the quality of included studies and extracted the data.Rev Man 5.0 software was used for Meta analysis.Results:Eleven randomized controlled trials with a total of 692 patients were included.Results of meta-analysis showed that the total effective rate of TGP group was higher than that of control group,and the difference was statistically significant[OR=3.36,95%CI(2.03,5.54),P<0.01].As to the adverse reaction,the TGP group has a rather lower incidence than that of control group,and the difference was statistically significant[OR=0.34,95%CI(0.21,0.53),P<0.01].At the same time,statistical significances were found in reducing C-reactive protein and Bath ankylosing spondylitis disease activity index between these two groups,result of Meta-analysis is[MD=-6.07,95%CI(-9.44,-2.70),P<0.01] and[MD=-2.66,95%CI(-5.16,-0.15),P<0.05] respectively.No statistically difference was found in reducing erythrocyte sedimentation rate and Bath ankylosing spondylitis functional index between these two groups,result of Meta-analysis is[MD=-2.20,95%CI(-9.52,5.12),P>0.05] and[MD=-7.50,95%CI(-21.31,6.31),P>0.05] respectively.Conclusions:TGP can improve clinical efficient and reduce adverse reaction significantly.
Objective:To analyze the therapeutic effects of total glucosides of paeony(TGP) for ankylosing spondylitis(AS).Methods:By literature analysis based on evidence-based medicine,randomized controlled trials about TGP in the treatment of AS were obtained from Chine National Knowledge infrastructure,VIP and PubMed.Evaluated the quality of included studies and extracted the data.Rev Man 5.0 software was used for Meta analysis.Results:Eleven randomized controlled trials with a total of 692 patients were included.Results of meta-analysis showed that the total effective rate of TGP group was higher than that of control group,and the difference was statistically significant[OR=3.36,95%CI(2.03,5.54),P<0.01].As to the adverse reaction,the TGP group has a rather lower incidence than that of control group,and the difference was statistically significant[OR=0.34,95%CI(0.21,0.53),P<0.01].At the same time,statistical significances were found in reducing C-reactive protein and Bath ankylosing spondylitis disease activity index between these two groups,result of Meta-analysis is[MD=-6.07,95%CI(-9.44,-2.70),P<0.01] and[MD=-2.66,95%CI(-5.16,-0.15),P<0.05] respectively.No statistically difference was found in reducing erythrocyte sedimentation rate and Bath ankylosing spondylitis functional index between these two groups,result of Meta-analysis is[MD=-2.20,95%CI(-9.52,5.12),P>0.05] and[MD=-7.50,95%CI(-21.31,6.31),P>0.05] respectively.Conclusions:TGP can improve clinical efficient and reduce adverse reaction significantly.
2015, 40(9): 1171-1173,1177.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.009
Abstract:
Objective:To investigate the effects of the high-does atorvastatin before urokinase treatment on the thrombolysis and recently left ventricular function.Methods:One hundred and ten diabetic patients with acute anterior wall myocardial infarction were randomly divided into the atorvastatin treatment group(60 cases) and routine treatment group(50 cases).The atorvastatin treatment group were treated with 80 mg by oral before urokinase thrombolysis.The serum levels of high sensitivity C reactive protein before thrombolysis and after 24 h of thrombolysis in two groups were measured.The echocardiography before thrombolysis and after 1 month of thrombolysis in two groups were detected.Results:The incidence of revascularization in the atorvastatin treatment group was higher than that in routine treatment group(P<0.05).The increasing serum level of high sensitivity C reactive protein after 24 h of thrombolysis was significantly lower than that in control group(P<0.01).Compared with before thrombolysis,the levels of left ventricular end diastolic volune index and left ventricular end systolic volune index in two groups significantly increased after 1 month of thrombolysis.Compared with before thrombolysis,the levels of left ventricular ejection fraction in two groups significantly decreased after 1 month of thrombolysis,the decreasing degree of which in the atorvastatin treatment group was significantly lower than that in routine treatment group(P<0.01).Conclusions:The high-does atorvastatin by oral before thrombolysis can significantly improve the incidence of revascularization in diabetic patients with acute anterior myocardial infarction,and may retard the declining of left ventricular function.
Objective:To investigate the effects of the high-does atorvastatin before urokinase treatment on the thrombolysis and recently left ventricular function.Methods:One hundred and ten diabetic patients with acute anterior wall myocardial infarction were randomly divided into the atorvastatin treatment group(60 cases) and routine treatment group(50 cases).The atorvastatin treatment group were treated with 80 mg by oral before urokinase thrombolysis.The serum levels of high sensitivity C reactive protein before thrombolysis and after 24 h of thrombolysis in two groups were measured.The echocardiography before thrombolysis and after 1 month of thrombolysis in two groups were detected.Results:The incidence of revascularization in the atorvastatin treatment group was higher than that in routine treatment group(P<0.05).The increasing serum level of high sensitivity C reactive protein after 24 h of thrombolysis was significantly lower than that in control group(P<0.01).Compared with before thrombolysis,the levels of left ventricular end diastolic volune index and left ventricular end systolic volune index in two groups significantly increased after 1 month of thrombolysis.Compared with before thrombolysis,the levels of left ventricular ejection fraction in two groups significantly decreased after 1 month of thrombolysis,the decreasing degree of which in the atorvastatin treatment group was significantly lower than that in routine treatment group(P<0.01).Conclusions:The high-does atorvastatin by oral before thrombolysis can significantly improve the incidence of revascularization in diabetic patients with acute anterior myocardial infarction,and may retard the declining of left ventricular function.
2015, 40(9): 1174-1177.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.010
Abstract:
Objective:To discuss the clinical value of using recreation therapy in cognitive disorder after stroke.Methods:From March 2010 to April 2014 in our hospital 78 cases of patients with cognitive impairment after stroke were chosen and divided into the control group and the observation group using random number method(39 cases in each group);The control group were given acupuncture,nimodipine in joint with limb rehabilitation treatment,while on basis of that the observation group were given recreation therapy;And respectively before treatment,4 weeks,8 weeks,12 weeks after treatment with concise mental state check table(MMSE) and neurobehavioral cognitive status checklist(NCSE) of all patients were investigated to evaluate the clinical curative effects.Results:Two groups patients after 4~12 weeks MMSE rates all increased compared with before treatment increased(P<0.05 to P<0.01);MMSE in the observation group were higher(P<0.05).Neurobehavioral cognitive status of patients in the control group after treatment,except when 4 weeks and 8 weeks orientation,concentration and language name and language negative ratings than before treatment improved(P<0.05 to P<0.01);compared with before treatment,the observation group in addition to patients was not statistically significant when mindfulness 4 weeks score before treatment difference(P>0.05),the other at each time point of neurobehavioral cognitive status score were improved(P<0.05 to P<0.01);4 weeks when the observation group concentration,language comprehension,language name,reasoning ability to judge scores the control group showed no significant difference(P>0.05) when the language repeat and 8 weeks,the rest of each individual scores were higher(P<0.05 to P<0.01).Conclusions:Using recreation therapy combined with traditional therapy could obviously improve the cognitive function in patients with cognitive impairment after stroke.
Objective:To discuss the clinical value of using recreation therapy in cognitive disorder after stroke.Methods:From March 2010 to April 2014 in our hospital 78 cases of patients with cognitive impairment after stroke were chosen and divided into the control group and the observation group using random number method(39 cases in each group);The control group were given acupuncture,nimodipine in joint with limb rehabilitation treatment,while on basis of that the observation group were given recreation therapy;And respectively before treatment,4 weeks,8 weeks,12 weeks after treatment with concise mental state check table(MMSE) and neurobehavioral cognitive status checklist(NCSE) of all patients were investigated to evaluate the clinical curative effects.Results:Two groups patients after 4~12 weeks MMSE rates all increased compared with before treatment increased(P<0.05 to P<0.01);MMSE in the observation group were higher(P<0.05).Neurobehavioral cognitive status of patients in the control group after treatment,except when 4 weeks and 8 weeks orientation,concentration and language name and language negative ratings than before treatment improved(P<0.05 to P<0.01);compared with before treatment,the observation group in addition to patients was not statistically significant when mindfulness 4 weeks score before treatment difference(P>0.05),the other at each time point of neurobehavioral cognitive status score were improved(P<0.05 to P<0.01);4 weeks when the observation group concentration,language comprehension,language name,reasoning ability to judge scores the control group showed no significant difference(P>0.05) when the language repeat and 8 weeks,the rest of each individual scores were higher(P<0.05 to P<0.01).Conclusions:Using recreation therapy combined with traditional therapy could obviously improve the cognitive function in patients with cognitive impairment after stroke.
2015, 40(9): 1178-1181.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.011
Abstract:
Objective:To explore the effects of vaginal radical trachelectomy(VRT) in treating the early cervical cancer and preserving fertility of patients.Methods:Fifty patients with the early cervical cancer were treated with VRT combined with laparoscopic pelvic lymph node resection.Among the patients,2 cases with pelvic lymph node and cervical margin involvement were treated with synchronized chemoradiotherapy.Results:Among 48 patients,all VRT operations were successful,the operation time and peroperative bleeding were(185±35) min and(310±131) ml,respectively.The cervical length and parametrium width of surgical excision were(2.6±0.6) cm and(1.9±0.5) cm,respectively.The number of lymph node excision was(26±10).The patients were followed up for(35±21) months.Six cases recurred during the following up period,the recurrence rate of which was 12.5%.The recurrence median time was 20 months.Three cases in 8 cases with tumor size more than 2 cm recurred,which was significantly higher than that in the patients with tumor size equal to or less than 2 cm(7.5%,P=0.049 7).Three cases with cadenocarcinoma or adenosquamous carcinoma recurred,the recurrence rate of which was higher than that in 7.1% of patients with squamous carcinoma(P=0.0198).During the equaal to or more than 6 months of following-up,35 patients desired to give birth to,13 women conceived 17 times,the pregnant rate of which was 37.1%.Nine women given birth to 10 newborns babies(1 cases conceived 2 times and were normal delivery),the fertility rate of which was 25.7%.Conclusions:VRT combined with laparoscopic pelvic lymph node resection can effectively preserve the fertility of patients with early cervical cancer.The patients with tumor size equal to or less than 2 cm are easy to recur,the indication of VRT should be strictly limited to the patients with tumor size equal to or less than 2 cm.
Objective:To explore the effects of vaginal radical trachelectomy(VRT) in treating the early cervical cancer and preserving fertility of patients.Methods:Fifty patients with the early cervical cancer were treated with VRT combined with laparoscopic pelvic lymph node resection.Among the patients,2 cases with pelvic lymph node and cervical margin involvement were treated with synchronized chemoradiotherapy.Results:Among 48 patients,all VRT operations were successful,the operation time and peroperative bleeding were(185±35) min and(310±131) ml,respectively.The cervical length and parametrium width of surgical excision were(2.6±0.6) cm and(1.9±0.5) cm,respectively.The number of lymph node excision was(26±10).The patients were followed up for(35±21) months.Six cases recurred during the following up period,the recurrence rate of which was 12.5%.The recurrence median time was 20 months.Three cases in 8 cases with tumor size more than 2 cm recurred,which was significantly higher than that in the patients with tumor size equal to or less than 2 cm(7.5%,P=0.049 7).Three cases with cadenocarcinoma or adenosquamous carcinoma recurred,the recurrence rate of which was higher than that in 7.1% of patients with squamous carcinoma(P=0.0198).During the equaal to or more than 6 months of following-up,35 patients desired to give birth to,13 women conceived 17 times,the pregnant rate of which was 37.1%.Nine women given birth to 10 newborns babies(1 cases conceived 2 times and were normal delivery),the fertility rate of which was 25.7%.Conclusions:VRT combined with laparoscopic pelvic lymph node resection can effectively preserve the fertility of patients with early cervical cancer.The patients with tumor size equal to or less than 2 cm are easy to recur,the indication of VRT should be strictly limited to the patients with tumor size equal to or less than 2 cm.
2015, 40(9): 1182-1183.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.012
Abstract:
Objective:To investigate the clinical application effects of heterogeneous particle skin graft in the treatment of deep burn.Methods:Eighty patients with deep burn were randomly divided into the study group and control group by cluster sampling method(40 cases each group).The control group and study group were treated with allogeneic skin graft covering and xenogenic skin graft covering,respectively.The survival rate of particle skin and wound healing time between two groups were statistically analyzed after 4 weeks of operation.Results:The wound healing time in study group was significantly shorter than that in control group(P<0.01).The difference of the particle skin survival rate between two groups was not statistical significance after the first 4 weeks of operation(P>0.05).Conclusions:The treatment of deep burn with skin graft covering the particles is safe,feasible and quick healing.
Objective:To investigate the clinical application effects of heterogeneous particle skin graft in the treatment of deep burn.Methods:Eighty patients with deep burn were randomly divided into the study group and control group by cluster sampling method(40 cases each group).The control group and study group were treated with allogeneic skin graft covering and xenogenic skin graft covering,respectively.The survival rate of particle skin and wound healing time between two groups were statistically analyzed after 4 weeks of operation.Results:The wound healing time in study group was significantly shorter than that in control group(P<0.01).The difference of the particle skin survival rate between two groups was not statistical significance after the first 4 weeks of operation(P>0.05).Conclusions:The treatment of deep burn with skin graft covering the particles is safe,feasible and quick healing.
2015, 40(9): 1184-1185,1188.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.013
Abstract:
Objective:To explore the effects of different drug therapy on the thyroid hormone level in patients with schizophrenia.Methods:One hundred and twenty patients with schizophrenia were randomly divided into group A(treatment with azole),group B(treatment with quetiapine) and group C(treatment with risperidone)(40 cases each group).The thyroid hormone levels in 3 groups between before treatment and after 1 month of treatment were compared.Results:The differences of the levels of three iodine thyroid glycine(T3),four iodine glycine(T4),free three iodine thyroid original glycine(FT3) and free iodine thyroid original glycine(FT4) between 3 groups before treatment were not statistically significant(P>0.05).After 1 month of therapy,the levels of T3,T4,FT3 and FT4 in 3 groups obviously decreased(P<0.01),and the lowest in group B(P<0.01),the level of FT3 in group A was significantly lover than group C(P<0.01),and the differences of whose between group A and group C were not statistically significant(P>0.05).Conclusions:Azole,quetiapine and risperidone can reduce the thyroid hormone level in patients with schizophrenia,and the decreasing degree in patients treated with quetiapine is the most obviously.
Objective:To explore the effects of different drug therapy on the thyroid hormone level in patients with schizophrenia.Methods:One hundred and twenty patients with schizophrenia were randomly divided into group A(treatment with azole),group B(treatment with quetiapine) and group C(treatment with risperidone)(40 cases each group).The thyroid hormone levels in 3 groups between before treatment and after 1 month of treatment were compared.Results:The differences of the levels of three iodine thyroid glycine(T3),four iodine glycine(T4),free three iodine thyroid original glycine(FT3) and free iodine thyroid original glycine(FT4) between 3 groups before treatment were not statistically significant(P>0.05).After 1 month of therapy,the levels of T3,T4,FT3 and FT4 in 3 groups obviously decreased(P<0.01),and the lowest in group B(P<0.01),the level of FT3 in group A was significantly lover than group C(P<0.01),and the differences of whose between group A and group C were not statistically significant(P>0.05).Conclusions:Azole,quetiapine and risperidone can reduce the thyroid hormone level in patients with schizophrenia,and the decreasing degree in patients treated with quetiapine is the most obviously.
2015, 40(9): 1186-1188.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.014
Abstract:
Objective:To explore the effects of mifepristone combined with misoprostol in the second trimester odinopoeia of pregnant women within 1-year after cesarean section.Methods:The second trimester odinopoeia women within 1-year after cesarean section in 24 cases and more than 2 years after cesarean section in 30 cases were divided into the experimental group and control group,respectively.Two groups were induced labor with mifepristone combined with misoprostol.Results:The differences of the success rate,dosage of misoprostol,time from the use of misoprostol to labor,amount of vaginal bleeding,placental residue,length of stay and incidence of cervical laceration were not statistical significance(P>0.05).Conclusions:The effects of mifepristone combined with misoprostol in the second trimester odinopoeia of pregnant women within 1-year after cesarean section are safe and reliable.
Objective:To explore the effects of mifepristone combined with misoprostol in the second trimester odinopoeia of pregnant women within 1-year after cesarean section.Methods:The second trimester odinopoeia women within 1-year after cesarean section in 24 cases and more than 2 years after cesarean section in 30 cases were divided into the experimental group and control group,respectively.Two groups were induced labor with mifepristone combined with misoprostol.Results:The differences of the success rate,dosage of misoprostol,time from the use of misoprostol to labor,amount of vaginal bleeding,placental residue,length of stay and incidence of cervical laceration were not statistical significance(P>0.05).Conclusions:The effects of mifepristone combined with misoprostol in the second trimester odinopoeia of pregnant women within 1-year after cesarean section are safe and reliable.
2015, 40(9): 1189-1191.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.015
Abstract:
Objective:To evaluate the clinical application of the percutaneous nephrolithotomy(PCNL) guided by B ultrasound in the treatment of calculous pyonephrosis under local anesthesia.Methods:Thirty-seven cases with calculous pyonephrosis were treated with phase Ⅰ renal biopsy to drain pus guided by B ultrasound under local anesthesia,then the patients were treated with phase Ⅱ standard channel percutaneous nephrolithotomy when the general conditions of patients were improved.Results:Thirty-seven cases were successfully punctured and removed the obstruction,the ipsilateral renal function in 30 cases and 7 cases recovered to normal and improved,respectively.The operation time of phase Ⅱ standard channel percutaneous nephrolithotomy was 25 to 84 min.No residual stones,systemic inflammatory response syndrome and severe bleeding in all cases were found,and the hospitalization time was 10 to 21 d.Conclusions:Phase Ⅰ renal biopsy drainage of pus and removing urinary tract obstruction can improve the security of the phase 2 PCNL,which has an important significance in treating calculus pyonephrosis.
Objective:To evaluate the clinical application of the percutaneous nephrolithotomy(PCNL) guided by B ultrasound in the treatment of calculous pyonephrosis under local anesthesia.Methods:Thirty-seven cases with calculous pyonephrosis were treated with phase Ⅰ renal biopsy to drain pus guided by B ultrasound under local anesthesia,then the patients were treated with phase Ⅱ standard channel percutaneous nephrolithotomy when the general conditions of patients were improved.Results:Thirty-seven cases were successfully punctured and removed the obstruction,the ipsilateral renal function in 30 cases and 7 cases recovered to normal and improved,respectively.The operation time of phase Ⅱ standard channel percutaneous nephrolithotomy was 25 to 84 min.No residual stones,systemic inflammatory response syndrome and severe bleeding in all cases were found,and the hospitalization time was 10 to 21 d.Conclusions:Phase Ⅰ renal biopsy drainage of pus and removing urinary tract obstruction can improve the security of the phase 2 PCNL,which has an important significance in treating calculus pyonephrosis.
2015, 40(9): 1191-1193.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.016
Abstract:
Objective:To investigate the perioperative treatment method and experience in high risk benign prostatic hyperplasia(BPH) patients treated with transurethral resection of prostate(TURP).Methods:The clinical data of 65 high-risk BPH patients treated with TURP were retrospectively analyzed.The differences of the indicators in all cases between before and after operation were compared.Results:Sixty-five patients successfully withstood the TURP,and security through the perioperative period.The death case,perioperative massive hemorrhage,transurethral resection syndrome,pulmonary infection and pulmonary embolism were not found.The differences of the International prostate symptom score,QOL,Qmax and residual urine volume between before operation and after 12 months of operation were statistically significant(P<0.05).Conclusions:Individualized treatment,strict monitoring,standardize operation,thorough hemostasis and postoperatively comprehensive treatment are all important to ensure the success of operation.
Objective:To investigate the perioperative treatment method and experience in high risk benign prostatic hyperplasia(BPH) patients treated with transurethral resection of prostate(TURP).Methods:The clinical data of 65 high-risk BPH patients treated with TURP were retrospectively analyzed.The differences of the indicators in all cases between before and after operation were compared.Results:Sixty-five patients successfully withstood the TURP,and security through the perioperative period.The death case,perioperative massive hemorrhage,transurethral resection syndrome,pulmonary infection and pulmonary embolism were not found.The differences of the International prostate symptom score,QOL,Qmax and residual urine volume between before operation and after 12 months of operation were statistically significant(P<0.05).Conclusions:Individualized treatment,strict monitoring,standardize operation,thorough hemostasis and postoperatively comprehensive treatment are all important to ensure the success of operation.
2015, 40(9): 1194-1195,1198.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.017
Abstract:
Objective:To study the clinical effects of the pulse pressure index(PPI) and systolic blood pressure variability(SBpV) on the patients with ischemic stroke.Methods:The 24-hours ambulatory blood pressure monitor(ABpM) in 208 patients with hypertension were implemented,and all patients were scaned with brain CT or MRI.The PPI was calculated and analyzed on the basis of PPI≥0.40 and systolic blood pressure standard deviation(SBpV-SD)≥12 mmHg.Results:The total incidence of the ischemic stroke was 43.27%(90 cases).PPI≥0.40,SBpV-SD≥12 mmHg,PPI≥0.40 and SBpV-SD≥12 mmHg,the incidence of the ischemic stroke of which was significantly higher that of patients with PPI<0.40,SBpV-SD<12 mmHg and PPI<0.40 complicated with SBpV-SD≤12 mmHg(P<0.01).Conclusions:During the 24-hours ABpM,the PPI≥0.40 and SBpV-SD≥12 mmHg is an important indicator in predicting the ischemic stroke.
Objective:To study the clinical effects of the pulse pressure index(PPI) and systolic blood pressure variability(SBpV) on the patients with ischemic stroke.Methods:The 24-hours ambulatory blood pressure monitor(ABpM) in 208 patients with hypertension were implemented,and all patients were scaned with brain CT or MRI.The PPI was calculated and analyzed on the basis of PPI≥0.40 and systolic blood pressure standard deviation(SBpV-SD)≥12 mmHg.Results:The total incidence of the ischemic stroke was 43.27%(90 cases).PPI≥0.40,SBpV-SD≥12 mmHg,PPI≥0.40 and SBpV-SD≥12 mmHg,the incidence of the ischemic stroke of which was significantly higher that of patients with PPI<0.40,SBpV-SD<12 mmHg and PPI<0.40 complicated with SBpV-SD≤12 mmHg(P<0.01).Conclusions:During the 24-hours ABpM,the PPI≥0.40 and SBpV-SD≥12 mmHg is an important indicator in predicting the ischemic stroke.
2015, 40(9): 1196-1198.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.018
Abstract:
Objective:To compare the curative effects of two surgical technique in the treatment of intertrochanteric fracture of elderly patient. Methods:Twenty-two elderly patients(age more than or equal to 76 years) with intertrochanteric fractures were treated with open reduction and internal fixation(locking anatomic plate or proximal femoral nail)(11 cases),and femoral head arthroplasty(11 cases).The intraoperative bleeding volume,operation time,hospitalization time and bed time,healing time of fracture and adverse reactions between two groups were compared.The postoperative functional recovery in all cases were evaluated using Harris Score system,the excellent and good rate of each group was calculated.Results:The femoral intertrochanteric fractures in 22 patients healed during the following period.The differences of intraoperative bleeding volume and operation time between two groups were not statistical significance(P>0.05).The hospitalization time and bed time in internal fixation group were longer than those in femoral head arthroplasty group(P<0.05 and P<0.01).Excellent in 7 cases,good in 3 cases,fair in 1 case and no error case in internal fixation group were found,the excellent and good rate of which was 90.9%.Excellent in 9 cases,good in 1 case and fair in 1 case in femoral head arthroplasty group were found,the excellent and good rate of which was 90.9%.Conclusions:The clinical effects of two treatment methods are good,surgical method is selected according to the stability degree of the femoral intertrochanteric fracture and condition of patients.
Objective:To compare the curative effects of two surgical technique in the treatment of intertrochanteric fracture of elderly patient. Methods:Twenty-two elderly patients(age more than or equal to 76 years) with intertrochanteric fractures were treated with open reduction and internal fixation(locking anatomic plate or proximal femoral nail)(11 cases),and femoral head arthroplasty(11 cases).The intraoperative bleeding volume,operation time,hospitalization time and bed time,healing time of fracture and adverse reactions between two groups were compared.The postoperative functional recovery in all cases were evaluated using Harris Score system,the excellent and good rate of each group was calculated.Results:The femoral intertrochanteric fractures in 22 patients healed during the following period.The differences of intraoperative bleeding volume and operation time between two groups were not statistical significance(P>0.05).The hospitalization time and bed time in internal fixation group were longer than those in femoral head arthroplasty group(P<0.05 and P<0.01).Excellent in 7 cases,good in 3 cases,fair in 1 case and no error case in internal fixation group were found,the excellent and good rate of which was 90.9%.Excellent in 9 cases,good in 1 case and fair in 1 case in femoral head arthroplasty group were found,the excellent and good rate of which was 90.9%.Conclusions:The clinical effects of two treatment methods are good,surgical method is selected according to the stability degree of the femoral intertrochanteric fracture and condition of patients.
2015, 40(9): 1199-1201.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.019
Abstract:
Objective:To compare the effects between uterus artery embolization and local excision in the treatment of uterine adenomyosis(AM) to provide the basis for clinical AM treatment.Methods:Among the 56 AM patients,27 cases(A group) and 29 cases(B group) were treated with local excision and uterine artery embolization,respectively.All cases were followed up for 24 months,the long-and short-term efficacy between two groups were compared.Results:The dysmenorrhea symptoms in two groups were improved after 6,12 and 24 months of operation,the difference of which was not statistically significant(P>0.05).Compare with that before operation,the uterine volume in two groups were obviously shrinked(P<0.01).Conclusions:Both uterus artery embolization and abdominal local excision are effective mothods in treating AM,which can reserve uterus for providing the pregnancy chance in the reproductive age women.
Objective:To compare the effects between uterus artery embolization and local excision in the treatment of uterine adenomyosis(AM) to provide the basis for clinical AM treatment.Methods:Among the 56 AM patients,27 cases(A group) and 29 cases(B group) were treated with local excision and uterine artery embolization,respectively.All cases were followed up for 24 months,the long-and short-term efficacy between two groups were compared.Results:The dysmenorrhea symptoms in two groups were improved after 6,12 and 24 months of operation,the difference of which was not statistically significant(P>0.05).Compare with that before operation,the uterine volume in two groups were obviously shrinked(P<0.01).Conclusions:Both uterus artery embolization and abdominal local excision are effective mothods in treating AM,which can reserve uterus for providing the pregnancy chance in the reproductive age women.
2015, 40(9): 1202-1203.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.020
Abstract:
Objective:To evaluate the clinical effects of the hip prosthetic replacement in treating the unstable intertrochanteric fracture in elderly patients.Methods:Twenty elderly patients with unstable intertroehanteric fraetures were treated with hip prosthetic replacement,and the excellent and good rate in all cases were evaluated by Harris scoring system.Results:All operation were successful operation,the patients were followed up for 6 to 36 months.The hip joint function recovered to the pre-injury level.The excellent and good rate evaluated by Harris scoring system was 90%.Conclusions:The treatment of the unstable intertrochanteric fracture in elderly patients with hip prosthetic replacement is a better choice.
Objective:To evaluate the clinical effects of the hip prosthetic replacement in treating the unstable intertrochanteric fracture in elderly patients.Methods:Twenty elderly patients with unstable intertroehanteric fraetures were treated with hip prosthetic replacement,and the excellent and good rate in all cases were evaluated by Harris scoring system.Results:All operation were successful operation,the patients were followed up for 6 to 36 months.The hip joint function recovered to the pre-injury level.The excellent and good rate evaluated by Harris scoring system was 90%.Conclusions:The treatment of the unstable intertrochanteric fracture in elderly patients with hip prosthetic replacement is a better choice.
2015, 40(9): 1204-1206.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.021
Abstract:
Objective:To compare the postoperative analgesia effects of dezocine at different time points on patients treated with radical prostatectomMethods:Fifty patients scheduled for the radical prostatectomy were randomly divided into Ⅰ group and Ⅱ group.The 0.05mg/kg of dezocine was intravenously injected in Ⅰ group at 10 min before anesthesia induction,the 0.05mg/kg of dezocine was intravenously injected in Ⅱ group at 10 min before the end of operation.The total and effective compression number of PCA after 12 and 24 hours of operation,and the Visual analog scale(VAS) scores and Bruggman comfort scale(BCS) scores after 2,4,6,12 and 24 hours of operation were observed.The postoperative adverse reactions in two groups were recorded.Results:The times of the total and effective compression of PCA after 12 and 24 hours of operation and use of fentanyl in Ⅰ group were lower than those in Ⅱ group(P<0.05 to P<0.01).The VAS scores after 2,4,6 and 12 hours of operation in Ⅰ group were lower than those in Ⅱ group,but the results of BCS scores were higher than the opposite(P<0.01).The difference of the incidence of adverse reaction was not statistical significance(P>0.05).Conclusions:The postoperative analgesia effects of dezocine combined with fentanyl PCA before anesthesia induction are good,which can decrease the use dose,which is little adverse reaction.
Objective:To compare the postoperative analgesia effects of dezocine at different time points on patients treated with radical prostatectomMethods:Fifty patients scheduled for the radical prostatectomy were randomly divided into Ⅰ group and Ⅱ group.The 0.05mg/kg of dezocine was intravenously injected in Ⅰ group at 10 min before anesthesia induction,the 0.05mg/kg of dezocine was intravenously injected in Ⅱ group at 10 min before the end of operation.The total and effective compression number of PCA after 12 and 24 hours of operation,and the Visual analog scale(VAS) scores and Bruggman comfort scale(BCS) scores after 2,4,6,12 and 24 hours of operation were observed.The postoperative adverse reactions in two groups were recorded.Results:The times of the total and effective compression of PCA after 12 and 24 hours of operation and use of fentanyl in Ⅰ group were lower than those in Ⅱ group(P<0.05 to P<0.01).The VAS scores after 2,4,6 and 12 hours of operation in Ⅰ group were lower than those in Ⅱ group,but the results of BCS scores were higher than the opposite(P<0.01).The difference of the incidence of adverse reaction was not statistical significance(P>0.05).Conclusions:The postoperative analgesia effects of dezocine combined with fentanyl PCA before anesthesia induction are good,which can decrease the use dose,which is little adverse reaction.
2015, 40(9): 1207-1209.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.022
Abstract:
Objective:To explore the efficacy and safety of the plasma radiofrequency ablation combined with ozone nucleoplasty in the treatment of intractable discogenic pain.Methods:Eighty patients with discogenic pain were randomly divided into the plasma radiofrequency ablation combined with ozone nucleoplasty group(A group) and simple plasma radiofrequency ablation combined with ozone nucleoplasty(B group)(40 cases each group).The treatment efficacy in two groups were observed.The pain and clinical effect in two groups after operation were evaluated using visual analog scale(VAS),and Japanese orthopaedics association(JOA) low back pain score and modified Macnab evaluation criteria,respectively.Results:The nucleoplasty in all patients were successful completed,and no spinal cord and nerve root injury,intervertebral space infection were found.The scores of VAS and modified JOA in A groups after 3 month of operation were better than that in B group(P<0.05 to P<0.01).The excellent and good rates in A group after 3d and 3month of operation were better than those in B group.Conclusions:The short-peroid clinical effect of the low temperature plasma radiofrequency ablation combined with ozone nucleoplasty in the treatment of discogenic pain is good,which is a kind of safe,effective and minimally invasive treatment.
Objective:To explore the efficacy and safety of the plasma radiofrequency ablation combined with ozone nucleoplasty in the treatment of intractable discogenic pain.Methods:Eighty patients with discogenic pain were randomly divided into the plasma radiofrequency ablation combined with ozone nucleoplasty group(A group) and simple plasma radiofrequency ablation combined with ozone nucleoplasty(B group)(40 cases each group).The treatment efficacy in two groups were observed.The pain and clinical effect in two groups after operation were evaluated using visual analog scale(VAS),and Japanese orthopaedics association(JOA) low back pain score and modified Macnab evaluation criteria,respectively.Results:The nucleoplasty in all patients were successful completed,and no spinal cord and nerve root injury,intervertebral space infection were found.The scores of VAS and modified JOA in A groups after 3 month of operation were better than that in B group(P<0.05 to P<0.01).The excellent and good rates in A group after 3d and 3month of operation were better than those in B group.Conclusions:The short-peroid clinical effect of the low temperature plasma radiofrequency ablation combined with ozone nucleoplasty in the treatment of discogenic pain is good,which is a kind of safe,effective and minimally invasive treatment.
2015, 40(9): 1210-1211.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.023
Abstract:
Objective:To explore the clinical significance of the QRS distortion of the terminal portion of ECG detection in determining the prognosis of patients with acute myocardial infarction(AMI).Methods:The AMI patients were divided into group A and group B according to the patients with the presence and absence of terminal QRS distortion in the first-time ECG diagnosis.The prognosis between two groups were compared after the same treatment.Results:Seventy-five percent patients with smoking history,62.5% of patients with angina pectoris history in A group were found,which was significantly higher than those in group B(37.5% and 25.0%)(P<0.01).The incidence of ventricular arrhythmia in group A(47.0%) was higher than that in group B(18.8%)(P<0.01).The left ventricular ejection fraction in group A(43±12)% was less than that in group B(53±11)%(P<0.01).Conclusions:The terminal QRS distortion in ECG diagnosis can be served as an important index in the evaluation of prognosis of AMI patients,which can make more scientific and accurate evaluation of prognosis.
Objective:To explore the clinical significance of the QRS distortion of the terminal portion of ECG detection in determining the prognosis of patients with acute myocardial infarction(AMI).Methods:The AMI patients were divided into group A and group B according to the patients with the presence and absence of terminal QRS distortion in the first-time ECG diagnosis.The prognosis between two groups were compared after the same treatment.Results:Seventy-five percent patients with smoking history,62.5% of patients with angina pectoris history in A group were found,which was significantly higher than those in group B(37.5% and 25.0%)(P<0.01).The incidence of ventricular arrhythmia in group A(47.0%) was higher than that in group B(18.8%)(P<0.01).The left ventricular ejection fraction in group A(43±12)% was less than that in group B(53±11)%(P<0.01).Conclusions:The terminal QRS distortion in ECG diagnosis can be served as an important index in the evaluation of prognosis of AMI patients,which can make more scientific and accurate evaluation of prognosis.
2015, 40(9): 1228-1230,1233.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.032
Abstract:
Objective:To observe the clinical effects of Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction in the treatment of thoracic obstruction.Methods:Forty patients with phlegm closed resistance type thoracic obstruction were randomly divided into the control group and observation group(20 cases each group).The control group were treated with oxygen,100 mg of Aspirin Enteric-coated tablets 1 time daily for anti-platelet aggregation,20 mg of isosorbide mononitrate tablet twice a day for expanding and improving myocardial ischemia and 10 mg of simvastatin before sleep every night for stabling the lipid plaque.The observation were additionally treated with Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction based on the control group treatment.The symptom score,electrocardiogram improvement rate,clinical curative effects andblood lipid between two groups were analyzed.Results:Except the lassitude score in control group,the symptoms scores in two groups after treatment were lower than those in before treatment(P<0.05 to P<0.01).The treatment effects,except the chest pain score,in observation group were better than those in control group(P<0.05 to P<0.01).Compared with those before treatment,the levels of low density lipoprotein cholesterol,triglyceride and total cholesterol in the two observation groups after treatment are significantly decreased(P<0.01),and the level of high density lipoprotein cholesterol isdid not significantly elevatedincrease(P>0.05).The levels of low density lipoprotein cholesterol and total cholesterol in the observation group are were lower than those in the control group(P<0.01 and P<0.05),and the level of high density lipoprotein cholesterol of the in observation group iswas higher than that of the control group after treatment(P<0.01).Conclusions:The clinical effects of Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction in the treatment of thoracic obstruction are good,which is worthy of clinical promotion.
Objective:To observe the clinical effects of Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction in the treatment of thoracic obstruction.Methods:Forty patients with phlegm closed resistance type thoracic obstruction were randomly divided into the control group and observation group(20 cases each group).The control group were treated with oxygen,100 mg of Aspirin Enteric-coated tablets 1 time daily for anti-platelet aggregation,20 mg of isosorbide mononitrate tablet twice a day for expanding and improving myocardial ischemia and 10 mg of simvastatin before sleep every night for stabling the lipid plaque.The observation were additionally treated with Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction based on the control group treatment.The symptom score,electrocardiogram improvement rate,clinical curative effects andblood lipid between two groups were analyzed.Results:Except the lassitude score in control group,the symptoms scores in two groups after treatment were lower than those in before treatment(P<0.05 to P<0.01).The treatment effects,except the chest pain score,in observation group were better than those in control group(P<0.05 to P<0.01).Compared with those before treatment,the levels of low density lipoprotein cholesterol,triglyceride and total cholesterol in the two observation groups after treatment are significantly decreased(P<0.01),and the level of high density lipoprotein cholesterol isdid not significantly elevatedincrease(P>0.05).The levels of low density lipoprotein cholesterol and total cholesterol in the observation group are were lower than those in the control group(P<0.01 and P<0.05),and the level of high density lipoprotein cholesterol of the in observation group iswas higher than that of the control group after treatment(P<0.01).Conclusions:The clinical effects of Shenlingbaizhu powder combined with Gualou Xiebai Banxia Decoction in the treatment of thoracic obstruction are good,which is worthy of clinical promotion.
2015, 40(9): 1231-1233.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.033
Abstract:
Objective:To explore the clinical effects of the combination of Chinese and western medicine in the treatment of gastric ulcer.Methods:One hundred and twenty-seven patients with gastric ulcer were randomly divided into the observation group(n=65) and control group(n=62) according to the number table method.The control group were treated with the conventional medicine(such as the omeprazole,amoxicillin and clarithromycin),the observation group were additionally treated with the self-made traditional Chinese Medicine on the basis of the western medicine.The quality of life scores before and after treatment in two groups were observed,and the total effective and recurrence rate between two groups were compared.Results:The difference of the quality of life score in two groups was not statistically significant before treatment(P>0.05).Compared with these before treatment,the scores of the physical function,psychological function and social function in two groups were significantly improved after treatment(P<0.01),the increasing degree of whose in observation group were significantly higher than those in control group(P<0.01).The clinical total effective rate in observation group(93.85%) was significantly higher than that in control group(82.26%)(P<0.01).The recurrence rates in observation group during the following up for 1,2 and 3 year were 3.08%,7.69% and 12.31%,respectively,whose in control group were 11.29%,19.35% and 30.65%,respectively,and whose in observation group were lower than those in control group(P<0.01).Conclusions:The treatment of gastric ulcer with the combination of Chinese and western medicine can significantly improve the quality of life,increase the therapeutic efficacy and decrease the relapse rate,and its effect is significantly better than that of western medicine and worthy of promotion.
Objective:To explore the clinical effects of the combination of Chinese and western medicine in the treatment of gastric ulcer.Methods:One hundred and twenty-seven patients with gastric ulcer were randomly divided into the observation group(n=65) and control group(n=62) according to the number table method.The control group were treated with the conventional medicine(such as the omeprazole,amoxicillin and clarithromycin),the observation group were additionally treated with the self-made traditional Chinese Medicine on the basis of the western medicine.The quality of life scores before and after treatment in two groups were observed,and the total effective and recurrence rate between two groups were compared.Results:The difference of the quality of life score in two groups was not statistically significant before treatment(P>0.05).Compared with these before treatment,the scores of the physical function,psychological function and social function in two groups were significantly improved after treatment(P<0.01),the increasing degree of whose in observation group were significantly higher than those in control group(P<0.01).The clinical total effective rate in observation group(93.85%) was significantly higher than that in control group(82.26%)(P<0.01).The recurrence rates in observation group during the following up for 1,2 and 3 year were 3.08%,7.69% and 12.31%,respectively,whose in control group were 11.29%,19.35% and 30.65%,respectively,and whose in observation group were lower than those in control group(P<0.01).Conclusions:The treatment of gastric ulcer with the combination of Chinese and western medicine can significantly improve the quality of life,increase the therapeutic efficacy and decrease the relapse rate,and its effect is significantly better than that of western medicine and worthy of promotion.
2015, 40(9): 1234-1237.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.034
Abstract:
Objective:To investigate the use of mobile phone among the college students,and explore the relationship between the mobile phone dependence and compulsive tendency.Methods:Two hundred and ninety-one female students of nursing profession from a Anhui college were anonymously investigated using the cluster sampling,self-rating questionnaire for adolescent problematic mobile phone use and Yale-Brown obsessive compulsive scale,the general condition and mobile phone use were analyzed.Results:The total average score of mobile phone dependence was(24.45±5.807),the high scores in 80 cases were found.The differences of the mobile dependence between different daily usage time and years of usage students were statistical significance(P<0.01 and P<0.05).The differences of the mobile dependence between different scores ranking and make-up examination subjects students were statistical significance(P<0.01).The phone dependence total score was positively correlation with compulsive symptom score(P<0.01).A linear stepwise regression analysis indicated that the total score of mobile dependence can predict the total score of compulsive symptom(β=0.202,P<0.01).Conclusions:The college student with more dependence of mobile phone is prone to compulsive tendency.Effective reducing the use time of mobile phone can help prevent the dependence of mobile phone and compulsive tendency.
Objective:To investigate the use of mobile phone among the college students,and explore the relationship between the mobile phone dependence and compulsive tendency.Methods:Two hundred and ninety-one female students of nursing profession from a Anhui college were anonymously investigated using the cluster sampling,self-rating questionnaire for adolescent problematic mobile phone use and Yale-Brown obsessive compulsive scale,the general condition and mobile phone use were analyzed.Results:The total average score of mobile phone dependence was(24.45±5.807),the high scores in 80 cases were found.The differences of the mobile dependence between different daily usage time and years of usage students were statistical significance(P<0.01 and P<0.05).The differences of the mobile dependence between different scores ranking and make-up examination subjects students were statistical significance(P<0.01).The phone dependence total score was positively correlation with compulsive symptom score(P<0.01).A linear stepwise regression analysis indicated that the total score of mobile dependence can predict the total score of compulsive symptom(β=0.202,P<0.01).Conclusions:The college student with more dependence of mobile phone is prone to compulsive tendency.Effective reducing the use time of mobile phone can help prevent the dependence of mobile phone and compulsive tendency.
2015, 40(9): 1238-1240.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.035
Abstract:
Objective:To investigate the distribution of risk factors of chronic diseases in Huaishang district residents and preventive knowledge to provide the basis of related intervention behavior.Methods:The risk factors of chronic diseases and related healthy knowledge in more than 18 years old residents in Huaishang District were investigated by stratified cluster sampling method.Results:The total smoking and drinking rates among the residents were 29.5% and 22.6%,respectively.The male smoking rate(46.6%) and drinking rate(38.6%) were higher than those in female(5.0% and 6.1%),respectively(P<0.01).The 62.2% of residents didn't take part in physical exercise,the difference of the nonexercise rate between male(61.7%) and female(62.7%) was not statistical significance(P>0.05).The 12.2% of residents didn't eat breakfast daily,23.0% of residents tastes were heavy,78.9% of residents didn't eat dairy products or less than 200 g per day and 8.4% of residents often ate pickled smoked products.The difference of the taste in men and women with unhealthy dietary behaviors was statistical significance(P<0.05),the difference of other factors between men and women was not statistical significance(P>0.05).Among the awareness rate of risk factors about the chronic diseases,the influence factors of obesity in hypertension and sugar in diabetes were the highest awareness rate.Health knowledge of residents came mainly from TV and doctors.Conclusions:Higher proportion of residents have the risk behaviors related to the chronic disease.The channel of residents obtaining the healthy knowledge is relatively single.Carrying out health education among the key people is necessary in order to reduce their health risk factors for chronic diseases.
Objective:To investigate the distribution of risk factors of chronic diseases in Huaishang district residents and preventive knowledge to provide the basis of related intervention behavior.Methods:The risk factors of chronic diseases and related healthy knowledge in more than 18 years old residents in Huaishang District were investigated by stratified cluster sampling method.Results:The total smoking and drinking rates among the residents were 29.5% and 22.6%,respectively.The male smoking rate(46.6%) and drinking rate(38.6%) were higher than those in female(5.0% and 6.1%),respectively(P<0.01).The 62.2% of residents didn't take part in physical exercise,the difference of the nonexercise rate between male(61.7%) and female(62.7%) was not statistical significance(P>0.05).The 12.2% of residents didn't eat breakfast daily,23.0% of residents tastes were heavy,78.9% of residents didn't eat dairy products or less than 200 g per day and 8.4% of residents often ate pickled smoked products.The difference of the taste in men and women with unhealthy dietary behaviors was statistical significance(P<0.05),the difference of other factors between men and women was not statistical significance(P>0.05).Among the awareness rate of risk factors about the chronic diseases,the influence factors of obesity in hypertension and sugar in diabetes were the highest awareness rate.Health knowledge of residents came mainly from TV and doctors.Conclusions:Higher proportion of residents have the risk behaviors related to the chronic disease.The channel of residents obtaining the healthy knowledge is relatively single.Carrying out health education among the key people is necessary in order to reduce their health risk factors for chronic diseases.
2015, 40(9): 1241-1243.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.036
Abstract:
Objective:Explore the effect of implementation of prescription management method of electrons on the quality of outpatient prescriptions in our hospital.Methods:A random sample without the use of electronic prescription system(2008 January to June) of the 3 000 prescriptions and the use of electronic prescription system(2009 January to June) of the 3 000 prescriptions,according to the drug instructions,"prescription management method","prescription review implementation specification(Trial)" and other statistical analysis was carried out,the main contents include:analysis whether the standard of prescription writing,clinical medication is reasonable and the use of antibacterial drugs.Results:Without the use of the measures for the administration of electronic prescription,non normative prescriptions accounted for 22.27%,the rate of irrational drug use in 11.20%,the usage rate of antibiotics was 60.3%,after the implementation of the measures for the administration of electronic prescription,non normative prescriptions accounted for 2.43%,the rate of irrational drug use was 1.26%,anti bacteria drug utilization rate was 39.4%,with a significant difference in the quality of the use of electronic prescriptions(P<0.01).Conclusions:The prescription management method of implementing electronic hospital outpatient prescription writing,can significantly improve the normative,rational clinical use of drugs,improve the quality of prescription,has obvious clinical significance.
Objective:Explore the effect of implementation of prescription management method of electrons on the quality of outpatient prescriptions in our hospital.Methods:A random sample without the use of electronic prescription system(2008 January to June) of the 3 000 prescriptions and the use of electronic prescription system(2009 January to June) of the 3 000 prescriptions,according to the drug instructions,"prescription management method","prescription review implementation specification(Trial)" and other statistical analysis was carried out,the main contents include:analysis whether the standard of prescription writing,clinical medication is reasonable and the use of antibacterial drugs.Results:Without the use of the measures for the administration of electronic prescription,non normative prescriptions accounted for 22.27%,the rate of irrational drug use in 11.20%,the usage rate of antibiotics was 60.3%,after the implementation of the measures for the administration of electronic prescription,non normative prescriptions accounted for 2.43%,the rate of irrational drug use was 1.26%,anti bacteria drug utilization rate was 39.4%,with a significant difference in the quality of the use of electronic prescriptions(P<0.01).Conclusions:The prescription management method of implementing electronic hospital outpatient prescription writing,can significantly improve the normative,rational clinical use of drugs,improve the quality of prescription,has obvious clinical significance.
2015, 40(9): 1244-1246.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.037
Abstract:
Objective:To explore the differences of five kinds of trace elements between edible cooking oil and hogwash oil.Methods:Different kinds of 5 parts edible oil and 1 part homemade lard oil,3 parts old cooking oil and 3 parts hogwash oil were collected.In each sample,0.3 ~ 0.4 g was weighed accurately.The samples were digested into a solution for determination by microwave.The contents of copper(Cu),zinc(Zn),manganese(Mn),lead(Pb) and iron(Fe) were determined by atomic absorption spectrometry.Results:In the experimental concentration range,the recovery rate was between 97.6% to 102.4%,the relative average deviation was 0.6% to 2.5%.The contents of 5 kinds of trace elements in old cooking oil were similar to soybean oil,and there had no differences of Cu,Zn,Mn and Pb contents between the edible oil and hogwash oil,whereas Fe content in old cooking oil and hogwash oil was higher than that in the edible oil(P<0.01).Conclusions:There had no statistical differences of elements Cu,Zn,Mn and Pb contents between the edible oil and hogwash oil.Fe content was increased in hogwash oil,which may be due to the long-term exposure to the iron products when the hogwash oil was refined and transported.
Objective:To explore the differences of five kinds of trace elements between edible cooking oil and hogwash oil.Methods:Different kinds of 5 parts edible oil and 1 part homemade lard oil,3 parts old cooking oil and 3 parts hogwash oil were collected.In each sample,0.3 ~ 0.4 g was weighed accurately.The samples were digested into a solution for determination by microwave.The contents of copper(Cu),zinc(Zn),manganese(Mn),lead(Pb) and iron(Fe) were determined by atomic absorption spectrometry.Results:In the experimental concentration range,the recovery rate was between 97.6% to 102.4%,the relative average deviation was 0.6% to 2.5%.The contents of 5 kinds of trace elements in old cooking oil were similar to soybean oil,and there had no differences of Cu,Zn,Mn and Pb contents between the edible oil and hogwash oil,whereas Fe content in old cooking oil and hogwash oil was higher than that in the edible oil(P<0.01).Conclusions:There had no statistical differences of elements Cu,Zn,Mn and Pb contents between the edible oil and hogwash oil.Fe content was increased in hogwash oil,which may be due to the long-term exposure to the iron products when the hogwash oil was refined and transported.
2015, 40(9): 1247-1249.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.038
Abstract:
Objective:To investigate the bacterial infection distribution and drug resistance in burn wound.Methods:The bacteria from the wound secretion of different stages in 326 burn patients were cultured and identified.The drug resistance of gram negative and gram positive bacteria were detected.Results:The gram negative bacilli accounted for 69.52%(219 trains) of 315 strains of pathogenic bacteria,the proportion of pseudomonas aeruginosa was the highest(25.71%).The gram positive cocci accounted for 25.08%,the proportion of staphylococcus aureus was the highest(9.52%).The drug resistance rates of pseudomonas aeruginosa to cotrimoxazole and amikacin were the highest(97.45%) and lowest(21.12%),respectively.The drug resistance rates of bauman acinetobacter to aztreonam ＆ cefotaxime and cefoperazone/sulbactam were the highest(100.00%) and lowest(29.59%),respectively.The drug resistance rates of Escherichia coli to cotrimoxazole and imipenem were the highest(79.48%) and lowest(0.00%),respectively.The drug resistance rates of klebsiella pneumoniae to piperacillin and meropenem were the highest(88.26%) and lowest(1.42%),respectively.The drug resistance rates of staphylococcus aureus ＆ Staphylococcus aureus to penicillin and linezolid ＆ vancomycin were the highest(94.62%＆ 96.37%) and lowermost(0.00% and 0.00%),respectively.Conclusions:The Gram-negative bacteria is mainly pathogenic bacteria in burn wound infection,the drug resistance of which increases.Knowing the distribution characteristics of pathogenic bacteria and timely monitoring its drug resistance can guide the rational drug use and control infection again.
Objective:To investigate the bacterial infection distribution and drug resistance in burn wound.Methods:The bacteria from the wound secretion of different stages in 326 burn patients were cultured and identified.The drug resistance of gram negative and gram positive bacteria were detected.Results:The gram negative bacilli accounted for 69.52%(219 trains) of 315 strains of pathogenic bacteria,the proportion of pseudomonas aeruginosa was the highest(25.71%).The gram positive cocci accounted for 25.08%,the proportion of staphylococcus aureus was the highest(9.52%).The drug resistance rates of pseudomonas aeruginosa to cotrimoxazole and amikacin were the highest(97.45%) and lowest(21.12%),respectively.The drug resistance rates of bauman acinetobacter to aztreonam ＆ cefotaxime and cefoperazone/sulbactam were the highest(100.00%) and lowest(29.59%),respectively.The drug resistance rates of Escherichia coli to cotrimoxazole and imipenem were the highest(79.48%) and lowest(0.00%),respectively.The drug resistance rates of klebsiella pneumoniae to piperacillin and meropenem were the highest(88.26%) and lowest(1.42%),respectively.The drug resistance rates of staphylococcus aureus ＆ Staphylococcus aureus to penicillin and linezolid ＆ vancomycin were the highest(94.62%＆ 96.37%) and lowermost(0.00% and 0.00%),respectively.Conclusions:The Gram-negative bacteria is mainly pathogenic bacteria in burn wound infection,the drug resistance of which increases.Knowing the distribution characteristics of pathogenic bacteria and timely monitoring its drug resistance can guide the rational drug use and control infection again.
2015, 40(9): 1252-1254.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.040
Abstract:
Objective:To evaluate the diagnostic value of elastography strain ratio combined with breast imaging repaoting and data system(BI-RADS) in the nature of breast small mass.Methods:The elastography strain ratios of 120 cases with BI-RADS grade 2 to 4 solid mammary masses diagnosed by ultrasound were detected.The nature of breast small masses were identified using the combined two methods,which was compared with the pathological result.Results:All breast masses were benign,which included 79 cases of fibroadenoma,39 cases of adenosis,1 case of intraductal papillomas and 1 case of fat necrosis.The grade 2 in 4 cases,grade 3 in 76 cases and grade 4 in 40 cases were identified by BI-RADS grade.The minimum,maximum and average?elastography strain ratio in 120 cases were 0.43 to 3.04 and(1.78±1.30),respectively.The 120 benign breast masses were diagnosed by the elastography strain ratio combined with BI-RADS,the diagnostic accordance rate of which was 100%.Conclusions:The elastography strain ratio combined with BI-RADS can improve the qualitative diagnosis of small breast mass,which can provide the appropriate case for mammotome.
Objective:To evaluate the diagnostic value of elastography strain ratio combined with breast imaging repaoting and data system(BI-RADS) in the nature of breast small mass.Methods:The elastography strain ratios of 120 cases with BI-RADS grade 2 to 4 solid mammary masses diagnosed by ultrasound were detected.The nature of breast small masses were identified using the combined two methods,which was compared with the pathological result.Results:All breast masses were benign,which included 79 cases of fibroadenoma,39 cases of adenosis,1 case of intraductal papillomas and 1 case of fat necrosis.The grade 2 in 4 cases,grade 3 in 76 cases and grade 4 in 40 cases were identified by BI-RADS grade.The minimum,maximum and average?elastography strain ratio in 120 cases were 0.43 to 3.04 and(1.78±1.30),respectively.The 120 benign breast masses were diagnosed by the elastography strain ratio combined with BI-RADS,the diagnostic accordance rate of which was 100%.Conclusions:The elastography strain ratio combined with BI-RADS can improve the qualitative diagnosis of small breast mass,which can provide the appropriate case for mammotome.
2015, 40(9): 1257-1261.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.042
Abstract:
Objective:To explore the effects of clinical pathway on patients with hypertension using Meta analysis.Methods:The application effects of the clinical pathway method and traditional treatment method on patients with hypertension were investigated by screening CNKI,VIP,Wanfang database and CBMdisc.Through the strict quality evaluation,all data were analyzed by using Rev Man5.1 software.Results:Two thousand and eighty-three objects from 15 documents were selected,which were divided into the clinical path way group(1 035 cases) and traditional treatment group(1 048 cases).The Meta-analysis results showed that the differences of the length of hospital stay[WMD=-3.15,95%CI(-4.64~-1.65),P<0.01],hospitalization expenses[WMD=-615.70,95%CI(-648.03~-583.38),P<0.01],satisfaction degree of patients[RR=1.26,95%CI(1.21~1.30),P<0.01],knowledge of health[RR=1.29,95%,CI(1.22~1.37),P<0.01],systolic blood pressure[WMD=-13.97,95%CI(-16.47~-11.47),P<0.01],diastolic blood pressure[WMD=-4.70,95%CI(-5.82~-3.59),P<0.01] and compliance behavior[RR=1.24,95%CI(1.19~1.28),P<0.01] between two groups were statistically significant.Conclusions:The effect of clinical path way in the application of patients with hypertension is better than that of traditional treatment.Because of the large differences of the quality of the documents and large samples,the design need more rigorous,and randomized controlled trial can be used to confirm this conclusion.
Objective:To explore the effects of clinical pathway on patients with hypertension using Meta analysis.Methods:The application effects of the clinical pathway method and traditional treatment method on patients with hypertension were investigated by screening CNKI,VIP,Wanfang database and CBMdisc.Through the strict quality evaluation,all data were analyzed by using Rev Man5.1 software.Results:Two thousand and eighty-three objects from 15 documents were selected,which were divided into the clinical path way group(1 035 cases) and traditional treatment group(1 048 cases).The Meta-analysis results showed that the differences of the length of hospital stay[WMD=-3.15,95%CI(-4.64~-1.65),P<0.01],hospitalization expenses[WMD=-615.70,95%CI(-648.03~-583.38),P<0.01],satisfaction degree of patients[RR=1.26,95%CI(1.21~1.30),P<0.01],knowledge of health[RR=1.29,95%,CI(1.22~1.37),P<0.01],systolic blood pressure[WMD=-13.97,95%CI(-16.47~-11.47),P<0.01],diastolic blood pressure[WMD=-4.70,95%CI(-5.82~-3.59),P<0.01] and compliance behavior[RR=1.24,95%CI(1.19~1.28),P<0.01] between two groups were statistically significant.Conclusions:The effect of clinical path way in the application of patients with hypertension is better than that of traditional treatment.Because of the large differences of the quality of the documents and large samples,the design need more rigorous,and randomized controlled trial can be used to confirm this conclusion.
2015, 40(9): 1262-1265.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.043
Abstract:
Objective:To explore the effects of health failure mode and effect analysis(HFMEA) on the prevention of pressure sore in spine surgery patients.Methods:The formation of HFMEA group of pressure sore in patients with spinal surgery in prone position was established,the reason of sore in the patients treated with spine surgery in prone position were analyzed between October 2014 and March 2015.The basic reasons of sore were identified by finding out the risk factors of need intervention,calculating the RPN and drawing the flow diagram of risk prevention of pressure sores,which was used to list the improvement failure mode,formulate,organize and implement the action plan.The RPN was compared before and after implementing HFMEA.Results:The RPN of failure mode significantly decreased after improving the flow diagram(P<0.01).Six cases with pressure sores before improvement and no case with pressure sore after improvement were found,the difference of which was statistically significant(P<0.05).Conclusions:The application of HFMEA in cause analysis and process improvement in prone position patient with spine surgery can effectively prevent pressure sore,and improve the nursing quality in operation.
Objective:To explore the effects of health failure mode and effect analysis(HFMEA) on the prevention of pressure sore in spine surgery patients.Methods:The formation of HFMEA group of pressure sore in patients with spinal surgery in prone position was established,the reason of sore in the patients treated with spine surgery in prone position were analyzed between October 2014 and March 2015.The basic reasons of sore were identified by finding out the risk factors of need intervention,calculating the RPN and drawing the flow diagram of risk prevention of pressure sores,which was used to list the improvement failure mode,formulate,organize and implement the action plan.The RPN was compared before and after implementing HFMEA.Results:The RPN of failure mode significantly decreased after improving the flow diagram(P<0.01).Six cases with pressure sores before improvement and no case with pressure sore after improvement were found,the difference of which was statistically significant(P<0.05).Conclusions:The application of HFMEA in cause analysis and process improvement in prone position patient with spine surgery can effectively prevent pressure sore,and improve the nursing quality in operation.
2015, 40(9): 1266-1268.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.044
Abstract:
Objective:To explore the effects of motivational interviewing on the compliance of limb function exercise in hemiplegia patients after neurosurgery surgery for providing the reference in the rehabilitation nursing.Methods:One hundred hemiplegia patients were randomly divided into the intervention group and control group by a randomized controlled study(50 cases each group).The intervention group and control group were treated with motivational interviewing and routine health education,respectively.The compliance of limb function exercise,activity function and daily living situation in two groups were evaluated before and after intervention.Results:The differences of the compliance of limb function exercise,activity function and daily living situation between two groups before intervention were not statistically significant(P>0.05).Compared with the control group,the compliance of limb function exercise,activity function and daily living situation in intervention group improved significantly after intervention(P<0.05 to P<0.01).Conclusions:The motivational interviewing intervention can improve the compliance of the limb function exercise in patients with hemiplegia.
Objective:To explore the effects of motivational interviewing on the compliance of limb function exercise in hemiplegia patients after neurosurgery surgery for providing the reference in the rehabilitation nursing.Methods:One hundred hemiplegia patients were randomly divided into the intervention group and control group by a randomized controlled study(50 cases each group).The intervention group and control group were treated with motivational interviewing and routine health education,respectively.The compliance of limb function exercise,activity function and daily living situation in two groups were evaluated before and after intervention.Results:The differences of the compliance of limb function exercise,activity function and daily living situation between two groups before intervention were not statistically significant(P>0.05).Compared with the control group,the compliance of limb function exercise,activity function and daily living situation in intervention group improved significantly after intervention(P<0.05 to P<0.01).Conclusions:The motivational interviewing intervention can improve the compliance of the limb function exercise in patients with hemiplegia.
2015, 40(9): 1269-1271.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.045
Abstract:
Objective:To explore the effects of knowledge-attitude-practice(KAP) mode on peripherally inserted central catheter(PICC) care in patients with esophageal surgery.Methods:Eighty-four patients were randomly divided into the control group and intervention group(42 cases in each group).The control group and intervention group were taught using routine health education mode and KAP mode(including health education and psychological nursing,et al),respectively.Two groups were followed up for 3 chemotherapy cycles.The compliance of catheter maintenance,occurrence of catheter-related complication,keeping time of catheter and KAP of PICC between two groups were compared.Results:The difference of the case of catheter maintenance delay between two groups was not statistically significant(P>0.05).The number of catheter maintenance delay in intervention group was significantly less than that in control group(P<0.01).The difference of the occurrence of complication between two groups was not statistically significant(P>0.05).The time of catheter indwelling time in intervention group was significantly longer than that in control group(P<0.01).The scores of KAP in control group were significantly lower than those in intervention group(P<0.01).Conclusions:The application of KAP mode in PICC patients with esophageal surgery can improve the compliance of patients,extend the catheter indwelling time,increase the knowledge of KAP and clinical nursing quality.
Objective:To explore the effects of knowledge-attitude-practice(KAP) mode on peripherally inserted central catheter(PICC) care in patients with esophageal surgery.Methods:Eighty-four patients were randomly divided into the control group and intervention group(42 cases in each group).The control group and intervention group were taught using routine health education mode and KAP mode(including health education and psychological nursing,et al),respectively.Two groups were followed up for 3 chemotherapy cycles.The compliance of catheter maintenance,occurrence of catheter-related complication,keeping time of catheter and KAP of PICC between two groups were compared.Results:The difference of the case of catheter maintenance delay between two groups was not statistically significant(P>0.05).The number of catheter maintenance delay in intervention group was significantly less than that in control group(P<0.01).The difference of the occurrence of complication between two groups was not statistically significant(P>0.05).The time of catheter indwelling time in intervention group was significantly longer than that in control group(P<0.01).The scores of KAP in control group were significantly lower than those in intervention group(P<0.01).Conclusions:The application of KAP mode in PICC patients with esophageal surgery can improve the compliance of patients,extend the catheter indwelling time,increase the knowledge of KAP and clinical nursing quality.
2015, 40(9): 1272-1274.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.046
Abstract:
Objective:To investigate the application of problem-based model of care in the rescue of critical patients in department of Neurology.Methods:A total of 206 critical patients in department of Neurology 206 were divided into the control group and observation group(103 cases each group) according to the hospital date.The control group and observation group were treated with the conventional nursing mode and problem-based care model intervention based on the conventional nursing mode,respectively.The successful rate of rescue,mortality rate,effective rescue time,average day of hospitalization and satisfaction degree of patients between two groups were compared.Results:After the intervention,the mortality and successful rescue rates in control group(21.36% and 68.93%) were higher and lower than those in observation group(9.71% and 85.44%),respectively.The differences of the mortality and successful rescue rates between two groups were statistically significant(P<0.05).The effective rescue and average day of hospitalization time in observation group were shorter than those in control group(P<0.01 and P<0.05).The satisfaction degree in observation group was better than that in control group(P<0.05).Conclusions:The application of problem-based model of care in the critical patients in department of Neurology can shorten the rescue time,improve the success rate and reduce mortality,which can be conducive to spreading in Neurology nursing work.
Objective:To investigate the application of problem-based model of care in the rescue of critical patients in department of Neurology.Methods:A total of 206 critical patients in department of Neurology 206 were divided into the control group and observation group(103 cases each group) according to the hospital date.The control group and observation group were treated with the conventional nursing mode and problem-based care model intervention based on the conventional nursing mode,respectively.The successful rate of rescue,mortality rate,effective rescue time,average day of hospitalization and satisfaction degree of patients between two groups were compared.Results:After the intervention,the mortality and successful rescue rates in control group(21.36% and 68.93%) were higher and lower than those in observation group(9.71% and 85.44%),respectively.The differences of the mortality and successful rescue rates between two groups were statistically significant(P<0.05).The effective rescue and average day of hospitalization time in observation group were shorter than those in control group(P<0.01 and P<0.05).The satisfaction degree in observation group was better than that in control group(P<0.05).Conclusions:The application of problem-based model of care in the critical patients in department of Neurology can shorten the rescue time,improve the success rate and reduce mortality,which can be conducive to spreading in Neurology nursing work.
2015, 40(9): 1275-1277,1278.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.047
Abstract:
Objective:To evaluate the application effects of the care program guided by roy adaptation model in the nursing of level 0 elderly diabetic foot patients.Methods:One hundred and seventy-two level 0 elderly diabetic foot patients were randomly divided into the observation group and control group,the treatment method of two group were the same.The observation group were nursed using care program guided by roy adaptation model,and the control group were nursed using the routine method.The sick foot recovery between two groups were compared after nursing.Results:The total effect rates(93.03%) of the observation group were higher than those of the contol group(66.28%)(P<0.01);the quality of life scores of the observation group were better than of the control group(P<0.01).Conclusions:Care program guided by roy adaptation model can significantly improved the adaptability,foot condition and quality of life of level 0 elderly diabetic foot patients,which is worthy of promotion.
Objective:To evaluate the application effects of the care program guided by roy adaptation model in the nursing of level 0 elderly diabetic foot patients.Methods:One hundred and seventy-two level 0 elderly diabetic foot patients were randomly divided into the observation group and control group,the treatment method of two group were the same.The observation group were nursed using care program guided by roy adaptation model,and the control group were nursed using the routine method.The sick foot recovery between two groups were compared after nursing.Results:The total effect rates(93.03%) of the observation group were higher than those of the contol group(66.28%)(P<0.01);the quality of life scores of the observation group were better than of the control group(P<0.01).Conclusions:Care program guided by roy adaptation model can significantly improved the adaptability,foot condition and quality of life of level 0 elderly diabetic foot patients,which is worthy of promotion.
2015, 40(9): 1278-1280.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.048
Abstract:
Objective:To explore the clinical safety and effects of blood glucose intervention nursing in perioperative patients with diabetes complicated with cataract.Methods:One hundred and eighteen patients(132 eyes) with diabetes complicated with cataract were divided randomly into the conventional glucose control group(control group,66 years in 60 cases) and intensive blood sugar treatment group(treatment group,66 years in 58 cases).The levels of blood sugar in all patients were effectively controlled before operation,then the patients were treated with phacoemulsification combined with intraocular lens implantation.The postoperative corrected visual acuity,hospital stay,complication,satisfaction and clinical efficacy between two groups were observed.Results:The postoperative corrected visual acuity and hospital stay in observation group were better and shorter those in control group,respectively(P<0.01).The total incidence of the bleeding,infection,oedema,adhesion and inflammatory response in observation group was lower than that in control group(P<0.01).The total effective rate and satisfaction in observation group(98.3% and 98.3%) were higher than those in control group(86.7% and 88.7%),respectively(P<0.05).Conclusions:The blood glucose intervention nursing in perioperative patients with diabetes complicated with cataract is conducive to increasing vision,decreasing the incidence of adverse reaction and effectively improving the life quality of patients.
Objective:To explore the clinical safety and effects of blood glucose intervention nursing in perioperative patients with diabetes complicated with cataract.Methods:One hundred and eighteen patients(132 eyes) with diabetes complicated with cataract were divided randomly into the conventional glucose control group(control group,66 years in 60 cases) and intensive blood sugar treatment group(treatment group,66 years in 58 cases).The levels of blood sugar in all patients were effectively controlled before operation,then the patients were treated with phacoemulsification combined with intraocular lens implantation.The postoperative corrected visual acuity,hospital stay,complication,satisfaction and clinical efficacy between two groups were observed.Results:The postoperative corrected visual acuity and hospital stay in observation group were better and shorter those in control group,respectively(P<0.01).The total incidence of the bleeding,infection,oedema,adhesion and inflammatory response in observation group was lower than that in control group(P<0.01).The total effective rate and satisfaction in observation group(98.3% and 98.3%) were higher than those in control group(86.7% and 88.7%),respectively(P<0.05).Conclusions:The blood glucose intervention nursing in perioperative patients with diabetes complicated with cataract is conducive to increasing vision,decreasing the incidence of adverse reaction and effectively improving the life quality of patients.
2015, 40(9): 1281-1283,1286.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.049
Abstract:
Objective:To discuss of the influence of empathy technique intervention on the life quality,psychological status and subjective well-being of patients with senile osteoporosis.Methods:One hundred and seventy patients with senile osteoporosis were randomly divided into control group and observation group(n=85 in each group).The patients in the control group were given only the routine nursing of senile osteoporosis,and the observation groups received psychological comfort,encouragement,symptomatic treatment and empathy technique in addition to the routine nursing.The quality of life,psychological status and subjective well-being of the two groups were observed.Results:After intervention,the score of life quality index rating scale of the observation group was significantly higher than that of the control group(P<0.05);the scores of Self-rating Anxiety Scale and Self-rating Depression Scale of the observation group were significantly lower than those of the control group(P<0.01);and the score of subjective well-being of the observation group was significantly higher than that of control group(P<0.01).Conclusions:Empathy technique can effectively improve the life quality of the elderly with osteoporosis,reduce their symptoms of anxiety and depression,and improve their subjective well-being.
Objective:To discuss of the influence of empathy technique intervention on the life quality,psychological status and subjective well-being of patients with senile osteoporosis.Methods:One hundred and seventy patients with senile osteoporosis were randomly divided into control group and observation group(n=85 in each group).The patients in the control group were given only the routine nursing of senile osteoporosis,and the observation groups received psychological comfort,encouragement,symptomatic treatment and empathy technique in addition to the routine nursing.The quality of life,psychological status and subjective well-being of the two groups were observed.Results:After intervention,the score of life quality index rating scale of the observation group was significantly higher than that of the control group(P<0.05);the scores of Self-rating Anxiety Scale and Self-rating Depression Scale of the observation group were significantly lower than those of the control group(P<0.01);and the score of subjective well-being of the observation group was significantly higher than that of control group(P<0.01).Conclusions:Empathy technique can effectively improve the life quality of the elderly with osteoporosis,reduce their symptoms of anxiety and depression,and improve their subjective well-being.
2015, 40(9): 1284-1286.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.050
Abstract:
Objective:To observe the clinical application effects of the zero defects nursing management in patients after cardiac operation.Methods:Forty-eight cardiac operation patients from January 2014 to June 2014 were divided into the observation group,who were treated with the zero defects nursing management,preparing related items and drugs,and strengthening the preoperative and postoperative nursing and management of the complications.The length of hospital stay,satisfaction score,quality of daily life and occurrence of postoperative complication between two groups were compared.Results:The length of hospital stay and satisfaction score in observation group were obviously less and higher than those in control group,respectively(P<0.01).The quality of daily life(including spirit,sleep,diet and psychologic status) in observation group were better than those in control group(P<0.05 to P<0.01).The difference of the incidence of complication(such as pulmonary infection) between two groups was not statistically significant(P>0.05).Conclusions:The application of zero defects nursing management can promote the rehabilitation of patients with heart operation.
Objective:To observe the clinical application effects of the zero defects nursing management in patients after cardiac operation.Methods:Forty-eight cardiac operation patients from January 2014 to June 2014 were divided into the observation group,who were treated with the zero defects nursing management,preparing related items and drugs,and strengthening the preoperative and postoperative nursing and management of the complications.The length of hospital stay,satisfaction score,quality of daily life and occurrence of postoperative complication between two groups were compared.Results:The length of hospital stay and satisfaction score in observation group were obviously less and higher than those in control group,respectively(P<0.01).The quality of daily life(including spirit,sleep,diet and psychologic status) in observation group were better than those in control group(P<0.05 to P<0.01).The difference of the incidence of complication(such as pulmonary infection) between two groups was not statistically significant(P>0.05).Conclusions:The application of zero defects nursing management can promote the rehabilitation of patients with heart operation.
2015, 40(9): 1287-1289.
doi: 10.13898/j.cnki.issn.1000-2200.2015.09.051
Abstract:
Objective:To explore the effects of continuing nursing on the postoperative quality life of cervical cancer patients treated with interventional therapy.Methods:Sixty-four cervical cancer patients treated with interventional therapy were randomly divided into the control group and experimental group.The control group and experimental group were treated with the conventional nursing and continuing nursing,respectively.The quality of life and nursing satisfaction in two groups were assessed by questionnaire after 6 months of discharged.Results:The functional area,symptom area and other improvement of symptom area in experimental group were better than those in control group(P<0.01).The satisfaction in experimental group and control group were 81.25% and 56.25%,the difference of which was statistical significance(P<0.05).Conclusions:Continuing nursing can improved the quality of life of cervical cancer patients treated with interventional therapy.
Objective:To explore the effects of continuing nursing on the postoperative quality life of cervical cancer patients treated with interventional therapy.Methods:Sixty-four cervical cancer patients treated with interventional therapy were randomly divided into the control group and experimental group.The control group and experimental group were treated with the conventional nursing and continuing nursing,respectively.The quality of life and nursing satisfaction in two groups were assessed by questionnaire after 6 months of discharged.Results:The functional area,symptom area and other improvement of symptom area in experimental group were better than those in control group(P<0.01).The satisfaction in experimental group and control group were 81.25% and 56.25%,the difference of which was statistical significance(P<0.05).Conclusions:Continuing nursing can improved the quality of life of cervical cancer patients treated with interventional therapy.
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